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17 results on '"Prendergast, Alexander"'

4. Pulmonary vasodilators in patients with advanced chronic kidney disease and pre‐capillary pulmonary hypertension—A case series.

Author

Leguizamon, Raul, McLaren, Ian, John, Tara, Khan, Rasha, Prendergast, Alexander, Wattanachayakul, Phuuwadith, Geller, Andrew, Malin, John, Jarret, Simone A., Lo, Kevin Bryan, Martinez Manzano, Jose Manuel, and Witzke, Christian

Subjects
PULMONARY hypertension, CHRONIC kidney failure, ENDOTHELIN receptors, CARDIAC catheterization, CHRONICALLY ill
Abstract

Pulmonary hypertension (PH) is a prevalent complication among patients with chronic kidney disease (CKD). In these patients, pulmonary vasodilators may be useful but are underused. We describe a group of patients with precapillary PH and advanced CKD treated with pulmonary vasodilators. This was a case series of patients with CKD stage 4 and 5 and precapillary PH (isolated or combined) based on right heart catheterization (RHC) treated with pulmonary vasodilators from 2018 to 2023. Of 263 patients with isolated precapillary or combined PH and advanced CKD, only 17 (6%) were treated with pulmonary vasodilators; 53% (n = 9) with precapillary PH and 47% (n = 8) with combined PH. Most patients (94%, n = 16) received phosphodiesterase‐5 antagonists, while 12% (n = 2) received endothelin receptor antagonists. Adverse clinical outcomes were seen in 35% of patients within a year. The use of pulmonary vasodilator did not prevent adverse outcomes in patients with precapillary PH and advanced CKD. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Association of mildly elevated pulmonary vascular resistance with major cardiovascular events in pulmonary hypertension and chronic kidney disease: A retrospective cohort analysis.

Author

Martinez Manzano, Jose M., Prendergast, Alexander, John, Tara, Leguizamon, Raul, McLaren, Ian, Khan, Rasha, Geller, Andrew, Wattanachayakul, Phuuwadith, Malin, John, Jarrett, Simone A., Lo, Kevin Bryan, Benzaquen, Sadia, and Witzke, Christian

Subjects
*PULMONARY hypertension, *CHRONIC kidney failure, *VASCULAR resistance, *MAJOR adverse cardiovascular events, *COHORT analysis
Abstract

Pulmonary hypertension (PH) is associated with adverse outcomes in chronic kidney disease (CKD) patients. Our study suggests mildly elevated pulmonary vascular resistance (> 2 to ≤ 3) is independently associated with major adverse cardiovascular events at 1‐year follow‐up. Early diagnosis of precapillary PH in CKD patients can potentially improve clinical outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Cardiovascular Outcomes After Angiotensin Converting Enzyme Inhibitor Induced Angioedema: A Retrospective Cohort Analysis

Author

Tito, Sahana, primary, Manzano, Jose Manuel Martinez, additional, Ogunmola, Isaac, additional, Prendergast, Alexander, additional, Patel, Anjeli, additional, Casipit, Bruce, additional, Cantu-Martinez, Omar, additional, Jarrett, Simone A., additional, Chiang, Brenda, additional, Sarvottam, Kumar, additional, Azmaiparashvili, Zurab, additional, Lo, Kevin Bryan, additional, and Rangaswami, Janani, additional

Published
2023
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11. Clinical predictors and outcomes of pulmonary infarction in patients with central pulmonary embolism

Author

Martinez Manzano, Jose Manuel, primary, Lo, Kevin Bryan, additional, Cantu-Martinez, Omar, additional, Nguyen, Long, additional, Chiang, Brenda, additional, Jarrett, Simone A., additional, Tito, Sahana, additional, Prendergast, Alexander, additional, Planchart Ferretto, Maria A., additional, Roque, Willy, additional, Wattoo, Ammaar, additional, Azmaiparashvili, Zurab, additional, and Benzaquen, Sadia, additional

Published
2023
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12. Clinical characteristics and treatment of patients with central pulmonary embolism and right heart thrombus

Author

Cantu‐Martinez, Omar, primary, Martinez Manzano, Jose Manuel, additional, Peterson, Eric, additional, Tito, Sahana, additional, Prendergast, Alexander, additional, Jarrett, Simone A., additional, Chiang, Brenda, additional, Wattoo, Ammaar, additional, Benzaquen, Sadia, additional, Lo, Kevin Bryan, additional, and Amanullah, Aman, additional

Published
2023
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16. Multilocus Genotyping of Giardia duodenalis in Mostly Asymptomatic Indigenous People from the Tapirapé Tribe, Brazilian Amazon

Author

Köster, Pamela Carolina, Malheiros, Antonio F., Shaw, Jeffrey J., Balasegaram, Sooria, Prendergast, Alexander, Lucaccioni, Héloïse, Moreira, Luciana Melhorança, Lemos, Larissa M. S., Dashti, Alejandro, Bailo, Begoña, Marcili, Arlei, Sousa Soares, Herbert, Gennari, Solange Maria, Calero Bernal, Rafael, González Barrio, David, Carmena, David, Köster, Pamela Carolina, Malheiros, Antonio F., Shaw, Jeffrey J., Balasegaram, Sooria, Prendergast, Alexander, Lucaccioni, Héloïse, Moreira, Luciana Melhorança, Lemos, Larissa M. S., Dashti, Alejandro, Bailo, Begoña, Marcili, Arlei, Sousa Soares, Herbert, Gennari, Solange Maria, Calero Bernal, Rafael, González Barrio, David, and Carmena, David

Abstract

Little information is available on the occurrence and genetic variability of the diarrhoea-causing enteric protozoan parasite Giardia duodenalis in indigenous communities in Brazil. This cross-sectional epidemiological survey describes the frequency, genotypes, and risk associations for this pathogen in Tapirapé people (Brazilian Amazon) at four sampling campaigns during 2008–2009. Microscopy was used as a screening test, and molecular (PCR and Sanger sequencing) assays targeting the small subunit ribosomal RNA, the glutamate dehydrogenase, the beta-giardin, and the triosephosphate isomerase genes as confirmatory/genotyping methods. Associations between G. duodenalis and sociodemographic and clinical variables were investigated using Chi-squared test and univariable/multivariable logistic regression models. Overall, 574 individuals belonging to six tribes participated in the study, with G. duodenalis prevalence rates varying from 13.5–21.7%. The infection was positively linked to younger age and tribe. Infected children <15 years old reported more frequent gastrointestinal symptoms compared to adults. Assemblage B accounted for three out of four G. duodenalis infections and showed a high genetic diversity. No association between assemblage and age or occurrence of diarrhoea was demonstrated. These data indicate that the most likely source of infection was anthropic and that different pathways (e.g., drinking water) may be involved in the transmission of the parasite., São Paulo State Research Support Foundation (FAFESP, Brazil), the National Health Foundation (FUNASA, Brazil), and the Mato Grosso State Research Support Foundation (FAPEMAT, Brazil), Instituto de Salud Carlos III/Ministerio de Economía y Competitividad, Depto. de Sanidad Animal, Fac. de Veterinaria, TRUE, pub

Published
2021

17. Multilocus Genotyping of Giardia duodenalis in Mostly Asymptomatic Indigenous People from the Tapirapé Tribe, Brazilian Amazon

Author

Köster, Pamela Carolina, primary, Malheiros, Antonio F., additional, Shaw, Jeffrey J., additional, Balasegaram, Sooria, additional, Prendergast, Alexander, additional, Lucaccioni, Héloïse, additional, Moreira, Luciana Melhorança, additional, Lemos, Larissa M. S., additional, Dashti, Alejandro, additional, Bailo, Begoña, additional, Marcili, Arlei, additional, Sousa Soares, Herbert, additional, Gennari, Solange Maria, additional, Calero-Bernal, Rafael, additional, González-Barrio, David, additional, and Carmena, David, additional

Published
2021
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