1. Do dried blood spots (DBS) have the potential to support result management processes in routine sports drug testing?
- Author
-
Tiia Kuuranne, Hans Geyer, Andreas Thomas, Mario Thevis, and Josef Dib
- Subjects
Drug ,medicine.medical_specialty ,Prednisolone ,media_common.quotation_subject ,Pharmaceutical Science ,Pilot Projects ,Performance-Enhancing Substances ,01 natural sciences ,Analytical Chemistry ,03 medical and health sciences ,0302 clinical medicine ,Cocaine ,Benzoyl ecgonine ,medicine ,Humans ,Environmental Chemistry ,030216 legal & forensic medicine ,Intensive care medicine ,Dried blood ,Spectroscopy ,media_common ,Doping in Sports ,business.industry ,010401 analytical chemistry ,Reference Standards ,Cocaine/analogs & derivatives ,Cocaine/blood ,Cocaine/urine ,Dried Blood Spot Testing/methods ,Performance-Enhancing Substances/blood ,Pharmaceutical Preparations/blood ,Pharmaceutical Preparations/urine ,Prednisolone/blood ,Prednisolone/urine ,Prednisone/blood ,Prednisone/urine ,Sports ,Substance Abuse Detection/methods ,alternative matrices ,doping ,mass spectrometry ,sport ,nervous system diseases ,0104 chemical sciences ,Substance Abuse Detection ,surgical procedures, operative ,Pharmaceutical Preparations ,nervous system ,Prednisone ,Dried Blood Spot Testing ,business - Abstract
Dried blood spots (DBS) have been considered as complementary matrix in sports drug testing for many years. Especially concerning substances prohibited in-competition only, the added value of DBS collected concomitantly with routine doping control urine samples has been debated, and an increasing potential of DBS has been discussed in the scientific literature. To which extent and under which prerequisites DBS can contribute to enhanced anti-doping efforts is currently evaluated. As a proof-of-principle, two analytical applications, one targeting cocaine/benzoyl ecgonine and the other prednisone/prednisolone, are presented in this perspective to indicate potential added value but also presently existing limitations of the DBS approach.
- Published
- 2020