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13 results on '"Pravata E."'

1. Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis

Author

Leone, M, Gelati, M, Profico, D, Gobbi, C, Pravata, E, Copetti, M, Conti, C, Abate, L, Amoruso, L, Apollo, F, Balzano, R, Bicchi, I, Carella, M, Ciampini, A, Colosimo, C, Crociani, P, D'Aloisio, G, Di Viesti, P, Ferrari, D, Fogli, D, Fontana, A, Frondizi, D, Grespi, V, Kuhle, J, Laborante, A, Lombardi, I, Muzi, G, Paci, F, Placentino, G, Popolizio, T, Ricciolini, C, Sabatini, S, Silveri, G, Spera, C, Stephenson, D, Stipa, G, Tinella, E, Zarrelli, M, Zecca, C, Ventura, Y, D'Alessandro, A, Peruzzotti-Jametti, L, Pluchino, S, Vescovi, A, Leone M. A., Gelati M., Profico D. C., Gobbi C., Pravata E., Copetti M., Conti C., Abate L., Amoruso L., Apollo F., Balzano R. F., Bicchi I., Carella M., Ciampini A., Colosimo C., Crociani P., D'Aloisio G., Di Viesti P., Ferrari D., Fogli D., Fontana A., Frondizi D., Grespi V., Kuhle J., Laborante A., Lombardi I., Muzi G., Paci F., Placentino G., Popolizio T., Ricciolini C., Sabatini S., Silveri G., Spera C., Stephenson D., Stipa G., Tinella E., Zarrelli M., Zecca C., Ventura Y., D'Alessandro A., Peruzzotti-Jametti L., Pluchino S., Vescovi A. L., Leone, M, Gelati, M, Profico, D, Gobbi, C, Pravata, E, Copetti, M, Conti, C, Abate, L, Amoruso, L, Apollo, F, Balzano, R, Bicchi, I, Carella, M, Ciampini, A, Colosimo, C, Crociani, P, D'Aloisio, G, Di Viesti, P, Ferrari, D, Fogli, D, Fontana, A, Frondizi, D, Grespi, V, Kuhle, J, Laborante, A, Lombardi, I, Muzi, G, Paci, F, Placentino, G, Popolizio, T, Ricciolini, C, Sabatini, S, Silveri, G, Spera, C, Stephenson, D, Stipa, G, Tinella, E, Zarrelli, M, Zecca, C, Ventura, Y, D'Alessandro, A, Peruzzotti-Jametti, L, Pluchino, S, Vescovi, A, Leone M. A., Gelati M., Profico D. C., Gobbi C., Pravata E., Copetti M., Conti C., Abate L., Amoruso L., Apollo F., Balzano R. F., Bicchi I., Carella M., Ciampini A., Colosimo C., Crociani P., D'Aloisio G., Di Viesti P., Ferrari D., Fogli D., Fontana A., Frondizi D., Grespi V., Kuhle J., Laborante A., Lombardi I., Muzi G., Paci F., Placentino G., Popolizio T., Ricciolini C., Sabatini S., Silveri G., Spera C., Stephenson D., Stipa G., Tinella E., Zarrelli M., Zecca C., Ventura Y., D'Alessandro A., Peruzzotti-Jametti L., Pluchino S., and Vescovi A. L.

Abstract

We report the analysis of 1 year of data from the first cohort of 15 patients enrolled in an open-label, first-in-human, dose-escalation phase I study (ClinicalTrials.gov: NCT03282760, EudraCT2015-004855-37) to determine the feasibility, safety, and tolerability of the transplantation of allogeneic human neural stem/progenitor cells (hNSCs) for the treatment of secondary progressive multiple sclerosis. Participants were treated with hNSCs delivered via intracerebroventricular injection in combination with an immunosuppressive regimen. No treatment-related deaths nor serious adverse events (AEs) were observed. All participants displayed stability of clinical and laboratory outcomes, as well as lesion load and brain activity (MRI), compared with the study entry. Longitudinal metabolomics and lipidomics of biological fluids identified time- and dose-dependent responses with increased levels of acyl-carnitines and fatty acids in the cerebrospinal fluid (CSF). The absence of AEs and the stability of functional and structural outcomes are reassuring and represent a milestone for the safe translation of stem cells into regenerative medicines.

Published
2023

3. Multimodal assessment of motor pathways and intracortical connections in functional hemispherectomy

Author

Pilato, Fabio, Pravata, E., Battaglia, Domenica Immacolata, Calandrelli, Rosalinda, Massimi, Luca, Di Rocco, C., Di Lazzaro, Vincenzo, Pilato F. (ORCID:0000-0002-7248-3916), Battaglia D. (ORCID:0000-0003-0491-4021), Calandrelli R., Massimi L., Di Lazzaro V., Pilato, Fabio, Pravata, E., Battaglia, Domenica Immacolata, Calandrelli, Rosalinda, Massimi, Luca, Di Rocco, C., Di Lazzaro, Vincenzo, Pilato F. (ORCID:0000-0002-7248-3916), Battaglia D. (ORCID:0000-0003-0491-4021), Calandrelli R., Massimi L., and Di Lazzaro V.

Abstract

Purpose: For selected children with medically intractable epilepsy, hemispherectomy can be an excellent treatment option and its efficacy in achieving seizure freedom or reduction in seizure frequency has been shown in several studies, but patients’ selection could not be straightforward and often it is taken on subjective basis. We described a multimodal approach to assess patient eligible for hemispherectomy and possibly predicting post-surgical outcomes. Methods: We describe pre- and post-surgical clinical features along with neuroradiological results by magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), MR-tractography (MRT), and neurophysiological study by single and paired pulses transcranial magnetic stimulation (TMS) in a child with cerebral palsy with epileptic encephalopathy, eligible for epilepsy surgery. Results: Presurgical TMS evaluation showed a lateralization of motor function on the left motor cortex for both arms, and results were confirmed by MRI studies. Interestingly, after surgery, both epilepsy and motor performances improved and TMS showed enhancement of intracortical inhibition and facilitation activity. Conclusion: Functional hemispherectomy is an effective treatment for drug-resistant epilepsy, and multimodal presurgical assessment may be a useful approach to guide surgeons in selecting patients. Moreover, pre- and post-surgical evaluation of these patients may enhance our understanding of brain plasticity phenomena.

Published
2020

4. Hippocampal-DMN disconnectivity in MS is related to WM lesions and depression

Author

Rocca, M, Pravata, E, Valsasina, P, Radaelli, M, Colombo, B, Vacchi, L, Gobbi, C, Comi, G, Falini, A, Filippi, M, Rocca M. A., Pravata E., Valsasina P., Radaelli M., Colombo B., Vacchi L., Gobbi C., Comi G., Falini A., Filippi M., Rocca, M, Pravata, E, Valsasina, P, Radaelli, M, Colombo, B, Vacchi, L, Gobbi, C, Comi, G, Falini, A, Filippi, M, Rocca M. A., Pravata E., Valsasina P., Radaelli M., Colombo B., Vacchi L., Gobbi C., Comi G., Falini A., and Filippi M.

Abstract

The hippocampus is part of the default-mode network (DMN) and is functionally hit early in multiple sclerosis (MS). Hippocampal and DMN dysfunctions have been associated with depression, both in patients with MS and in major depressive disorders. We hypothesized that white matter lesions may contribute, through a disconnection mechanism, to hippocampal dysfunction. To test this, we assessed the relationship between hippocampal resting-state (RS) functional connectivity (FC) abnormalities with brain T2 lesion volumes and the presence and severity of depression. Structural and RS fMRI images were acquired from 69 patients with cognitively intact MS and 42 matched healthy controls (HC). Depression was quantified using the Montgomery-Asberg Depression Rating Scale. Seed-voxel hippocampal RS FC was assessed. SPM8 was used for between-group comparisons and correlation analysis between RS FC abnormalities with clinical and structural MRI variables. Compared to HC, patients with MS showed a significant atrophy of the whole brain and left hippocampus (P<0.001), and a distributed pattern of decreased RS FC between the hippocampi and several cortical-subcortical regions, which were mostly located within the DMN. Reduced hippocampal RS FC with regions of the DMN was strongly correlated with higher T2 lesion volume, longer disease duration, and the severity of depression and disability. In patients with cognitively preserved MS, brain focal WM lesions are related to the functional integration of the hippocampus to other brain regions of the DMN, suggesting a disconnection syndrome. Such a disruption of hippocampal RS FC is likely to contribute to the occurrence of depression and to clinical disability. Hum Brain Mapp 36:5051-5063, 2015.

Published
2015

6. Functional Connectivity MR Imaging of the Language Network in Patients with Drug-Resistant Epilepsy

Author

Pravata', E, Sestieri, C, Mantini, D, Briganti, C, Colicchio, Gabriella, Marra, Camillo, Colosimo, Cesare, Tartaro, A, Romani, Gl, Caulo, M., Marra, Camillo (ORCID:0000-0003-3994-4044), Colosimo, Cesare (ORCID:0000-0003-3800-3648), Pravata', E, Sestieri, C, Mantini, D, Briganti, C, Colicchio, Gabriella, Marra, Camillo, Colosimo, Cesare, Tartaro, A, Romani, Gl, Caulo, M., Marra, Camillo (ORCID:0000-0003-3994-4044), and Colosimo, Cesare (ORCID:0000-0003-3800-3648)

Published
2010

7. A case of stroke induced micrographia

Author

Capone, F., Pilato, F., Profice, P., Pravata, E., and Di Lazzaro, V.

Subjects
Stroke (Disease) -- Diagnosis, Stroke (Disease) -- Case studies, Penmanship -- Abnormalities, Health, Psychology and mental health
Published
2009

9. Leman-PV as a clinical decision-support tool to assess MS activity: a multicentric longitudinal study at 1.5T and 3T MRI

Author

Todea, R. -A., Melie-Garcia, L., Barakovic, M., Siebenborn, N., Rahmanzadeh, R., Galbusera, R., Lu, P. -J., Weigel, M., Ruberte, E., Radue, E. W., Schadelin, S., Benkert, P., Yaldizli, O., Oechtering, J., Sinnecker, T., Mueller, S., Achtnichts, L., Vehoff, J., Disanto, G., Findling, O., Chan, A., Salmen, A., Pot, C., Lalive, P., Bridel, C., Zecca, C., Derfuss, T., Remonda, L., Wagner, F., Vargas, M. I., Du Pasquier, R., Pravata, E., Weber, J., Gobbi, C., Leppert, D., Wuerfel, J., Kober, T., Marechal, B., Corredor-Jerez, R., Psychogios, M. -N., Lieb, J., Kappos, L., Cuandra, M. Bach, Kuhle, J., and Granziera, C.

11. Influence of CNS T2-focal lesions on cervical cord atrophy and disability in multiple sclerosis

Author

Maria A. Rocca, Gianna C Riccitelli, Chiara Zecca, Massimo Filippi, Paola Valsasina, Emanuele Pravatà, Claudio Gobbi, Pravata, E., Valsasina, P., Gobbi, C., Zecca, C., Riccitelli, G. C., Filippi, M., and Rocca, M. A.

Subjects
Pathology, medicine.medical_specialty, Multiple Sclerosis, thoracic spinal cord, Cervical cord, cervical spinal cord, Disability Evaluation, Atrophy, Upper thoracic spinal cord, medicine, Humans, magnetic resonance imaging, Multiple sclerosi, medicine.diagnostic_test, business.industry, Multiple sclerosis, Brain, Cervical Cord, Magnetic resonance imaging, Spinal cord, medicine.disease, Magnetic Resonance Imaging, medicine.anatomical_structure, Neurology, Spinal Cord, Neurology (clinical), business
Abstract

Background: Mechanisms associated with cervical spinal cord (CSC) and upper thoracic spinal cord (TSC) atrophy in multiple sclerosis (MS) are poorly understood. Objective: To assess the influence of brain, CSC and TSC T2-hyperintense lesions on cord atrophy and disability in MS. Methods: Thirty-four MS patients underwent 3T brain, cervical and thoracic cord magnetic resonance imaging (MRI) and Expanded Disability Status Scale (EDSS) score assessment. CSC/TSC lesion number and volume (LV), whole-brain and cortico-spinal tract (CST) LVs were obtained. Normalized whole CSC and upper TSC cross-sectional areas (CSAn) were also derived. Age- and sex-adjusted regression models assessed associations of brain/cord lesions with CSAn and EDSS and identified variables independently associated with CSAn and EDSS with a stepwise variable selection. Results: CSC CSAn (β = −0.36, p = 0.03) and TSC CSAn (β = −0.60, p 2 = 0.20, p = 0.023) and TSC CSAn ( R2 = 0.51, p 2 = 0.55, p = 0.001). Conclusions: CSC LV is an independent predictor of cord atrophy. When neurological impairment is relatively mild, central nervous system (CNS) lesion burden is a better correlate of disability than atrophy.

Published
2020

12. Hippocampal‐ <scp>DMN</scp> disconnectivity in <scp>MS</scp> is related to <scp>WM</scp> lesions and depression

Author

Massimo Filippi, Emanuele Pravatà, Maria A. Rocca, Laura Vacchi, Marta Radaelli, Bruno Colombo, Claudio Gobbi, Paola Valsasina, Giancarlo Comi, Andrea Falini, Rocca, M, Pravata, E, Valsasina, P, Radaelli, M, Colombo, B, Vacchi, L, Gobbi, C, Comi, G, Falini, A, Filippi, M, Rocca, Ma, Pravatà, E, Comi, Giancarlo, Falini, Andrea, and Filippi, Massimo

Subjects
Adult, Male, medicine.medical_specialty, Multiple Sclerosis, Models, Neurological, Hippocampal formation, Hippocampus, Severity of Illness Index, Brain mapping, Functional Laterality, Statistics, Nonparametric, Lesion, Disability Evaluation, Hippocampu, Internal medicine, Neural Pathways, Image Processing, Computer-Assisted, medicine, Disconnection syndrome, Humans, Multiple sclerosi, Radiology, Nuclear Medicine and imaging, Resting-state fMRI, Research Articles, Default mode network, Brain Mapping, Radiological and Ultrasound Technology, Resting state fMRI, Depression, Multiple sclerosis, WM lesions, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Hyperintensity, Oxygen, Endocrinology, Default-mode network, Neurology, Case-Control Studies, Female, Neurology (clinical), Anatomy, medicine.symptom, Psychology, Neuroscience
Abstract

The hippocampus is part of the default‐mode network (DMN) and is functionally hit early in multiple sclerosis (MS). Hippocampal and DMN dysfunctions have been associated with depression, both in patients with MS and in major depressive disorders. We hypothesized that white matter lesions may contribute, through a disconnection mechanism, to hippocampal dysfunction. To test this, we assessed the relationship between hippocampal resting‐state (RS) functional connectivity (FC) abnormalities with brain T2 lesion volumes and the presence and severity of depression. Structural and RS fMRI images were acquired from 69 patients with cognitively intact MS and 42 matched healthy controls (HC). Depression was quantified using the Montgomery–Asberg Depression Rating Scale. Seed‐voxel hippocampal RS FC was assessed. SPM8 was used for between‐group comparisons and correlation analysis between RS FC abnormalities with clinical and structural MRI variables. Compared to HC, patients with MS showed a significant atrophy of the whole brain and left hippocampus (P

Published
2015
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13. A Multicenter Longitudinal MRI Study Assessing LeMan-PV Software Accuracy in the Detection of White Matter Lesions in Multiple Sclerosis Patients.

Author

Todea AR, Melie-Garcia L, Barakovic M, Cagol A, Rahmanzadeh R, Galbusera R, Lu PJ, Weigel M, Ruberte E, Radue EW, Schaedelin S, Benkert P, Oezguer Y, Sinnecker T, Müller S, Achtnichts L, Vehoff J, Disanto G, Findling O, Chan A, Salmen A, Pot C, Lalive P, Bridel C, Zecca C, Derfuss T, Remonda L, Wagner F, Vargas M, Du Pasquier R, Pravata E, Weber J, Gobbi C, Leppert D, Wuerfel J, Kober T, Marechal B, Corredor-Jerez R, Psychogios M, Lieb J, Kappos L, Cuadra MB, Kuhle J, and Granziera C

Subjects
Male, Humans, Adult, Middle Aged, Cohort Studies, Retrospective Studies, Magnetic Resonance Imaging methods, Brain diagnostic imaging, Brain pathology, Multiple Sclerosis diagnostic imaging, Multiple Sclerosis pathology, White Matter diagnostic imaging, White Matter pathology
Abstract

Background: Detecting new and enlarged lesions in multiple sclerosis (MS) patients is needed to determine their disease activity. LeMan-PV is a software embedded in the scanner reconstruction system of one vendor, which automatically assesses new and enlarged white matter lesions (NELs) in the follow-up of MS patients; however, multicenter validation studies are lacking., Purpose: To assess the accuracy of LeMan-PV for the longitudinal detection NEL white-matter MS lesions in a multicenter clinical setting., Study Type: Retrospective, longitudinal., Subjects: A total of 206 patients with a definitive MS diagnosis and at least two follow-up MRI studies from five centers participating in the Swiss Multiple Sclerosis Cohort study. Mean age at first follow-up = 45.2 years (range: 36.9-52.8 years); 70 males., Field Strength/sequence: Fluid attenuated inversion recovery (FLAIR) and T1-weighted magnetization prepared rapid gradient echo (T1-MPRAGE) sequences at 1.5 T and 3 T., Assessment: The study included 313 MRI pairs of datasets. Data were analyzed with LeMan-PV and compared with a manual "reference standard" provided by a neuroradiologist. A second rater (neurologist) performed the same analysis in a subset of MRI pairs to evaluate the rating-accuracy. The Sensitivity (Se), Specificity (Sp), Accuracy (Acc), F1-score, lesion-wise False-Positive-Rate (aFPR), and other measures were used to assess LeMan-PV performance for the detection of NEL at 1.5 T and 3 T. The performance was also evaluated in the subgroup of 123 MRI pairs at 3 T., Statistical Tests: Intraclass correlation coefficient (ICC) and Cohen's kappa (CK) were used to evaluate the agreement between readers., Results: The interreader agreement was high for detecting new lesions (ICC = 0.97, Pvalue < 10 -20 , CK = 0.82, P value = 0) and good (ICC = 0.75, P value < 10 -12 , CK = 0.68, P value = 0) for detecting enlarged lesions. Across all centers, scanner field strengths (1.5 T, 3 T), and for NEL, LeMan-PV achieved: Acc = 61%, Se = 65%, Sp = 60%, F1-score = 0.44, aFPR = 1.31. When both follow-ups were acquired at 3 T, LeMan-PV accuracy was higher (Acc = 66%, Se = 66%, Sp = 66%, F1-score = 0.28, aFPR = 3.03)., Data Conclusion: In this multicenter study using clinical data settings acquired at 1.5 T and 3 T, and variations in MRI protocols, LeMan-PV showed similar sensitivity in detecting NEL with respect to other recent 3 T multicentric studies based on neural networks. While LeMan-PV performance is not optimal, its main advantage is that it provides automated clinical decision support integrated into the radiological-routine flow., Evidence Level: 4 TECHNICAL EFFICACY: Stage 2., (© 2023 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)

Published
2023
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