Search

A 48-year-old woman was evaluated for a 40-year history of medically refractory absence and generalized tonic-clonic seizures. Neurologic examination and brain MRI were normal. Awake interictal EEG showed generalized fast spike-wave complex, always right hemispheric maximal ([figure 1][1]).

A 64-year-old man was evaluated for seizures due to traumatic brain injury 25 years previously. Physical examination revealed aphasia, right hemiplegia, and clubbing of all fingers of the hemiplegic arm (figures 1 and 2). Digital clubbing is a bulbous beaked fingertip deformity due …

The atypical neuroleptic, olanzapine (OLZ), may induce electroencephalographic (EEG) abnormalities. The anticonvulsant, lamotrigine (LMG), reduces interictal epileptiform discharges and is effective in seizures in patients with both primary and partial epilepsy syndromes. The effect of LMG on neuroleptic-induced EEG abnormalities has not been previously reported. We describe the case of a 13-year-old male with paroxysmal nonepileptic spells who underwent diagnostic video-EEG telemetry, whose abnormal OLZ-induced EEG findings were strikingly affected by LTG withdrawal and reintroduction. The effect of LTG in normalizing EEG changes in suspected epilepsy caused by atypical neuroleptics is discussed.