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Paranoid pseudocommunities may at times be a resistant and interesting symptom in patients with schizophrenia. A paranoid pseudocommunity is defined as an imaginary group of real persons or imagined persons believed in delusions to be conspiring against a paranoid individual. Herein, we report the case of a 61-year-old male with untreated schizophrenia for 36 years with auditory hallucinations constituting voices of twenty different people that were a part of a reciprocal paranoid pseudocommunity, and we explore the symptom phenomenologically and clinically.

c-KIT is a receptor tyrosine kinase reported in, small cell lung cancer and other human cancers. Marketed c-KIT inhibitors are suffering from tribulations of getting resistance and/or potential cardio toxicity. To identify potential novel c-KIT inhibitors, in the present project work, we have built an atom-featured 3D QSAR model using Schrodinger’s Maestro 9.0 molecular modeling suit. The developed 3D QSAR model ‘ADHRR.21’ is statistically significant (R2=0.8764, Q2 =0.7432) and instituted to be robust enough with good predictive accuracy, confirmed by external validation approaches, Y-randomization.

A simple and clean green method was implemented for the preparation of different succinimide derivatives by means of the N-substituted anilines or N-substituted 2-aminopyridines with succinic anhydride with the heating in an aqueous medium. The total synthesized 3a-j compounds were evaluated against antibacterial and antifungal species.

Patients diagnosed with cancer often suffer from chronic pain. Management of pain is essential to improve the quality of life of patients. When the standard methods for pain management fail, novel techniques can be implemented. Ketamine is a dissociative anesthetic agent which acts by reducing the central sensitization to pain. We report the case of a patient suffering from intractable pain as a result of Stage IV-C supraglottic laryngeal malignancy that responded well to intravenous ketamine.

We report the efficient synthesis of N-sulfonyl β-arylalanines methyl ester through regioselective ring opening of N-protected aziridines by variety of heteroaryl C-nucleophiles. We have optimized ...

c-KIT is a component of the platelet-derived growth factor receptor family, classified as type-III receptor tyrosine kinase. c-KIT has been reported to be involved in, small cell lung cancer, other malignant human cancers, and inflammatory and autoimmune diseases associated with mast cells. Available c-KIT inhibitors suffer from tribulations of growing resistance or cardiac toxicity. A combined in silico pharmacophore and structure-based virtual screening was performed to identify novel potential c-KIT inhibitors. In the present study, five molecules from the ZINC database were retrieved as new potential c-KIT inhibitors, using Schrodinger's Maestro 9.0 molecular modeling suite. An atom-featured 3D QSAR model was built using previously reported c-KIT inhibitors containing the indolin-2-one scaffold. The developed 3D QSAR model ADHRR.24 was found to be significant (R2 = 0.9378, Q2 = 0.7832) and instituted to be sufficiently robust with good predictive accuracy, as confirmed through external validation approaches, Y-randomization and GH approach [GH score 0.84 and Enrichment factor (E) 4.964]. The present QSAR model was further validated for the OECD principle 3, in that the applicability domain was calculated using a "standardization approach." Molecular docking of the QSAR dataset molecules and final ZINC hits were performed on the c-KIT receptor (PDB ID: 3G0E). Docking interactions were in agreement with the developed 3D QSAR model. Model ADHRR.24 was explored for ligand-based virtual screening followed by in silico ADME prediction studies. Five molecules from the ZINC database were obtained as potential c-KIT inhibitors with high in -silico predicted activity and strong key binding interactions with the c-KIT receptor.