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2. Consensus-based technical recommendations for clinical translation of renal BOLD MRI.

Author

Bane, Octavia, Mendichovszky, Iosif A, Milani, Bastien, Dekkers, Ilona A, Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael E, Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach O, Liu, Chunlei, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth A, Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Wang, Zhen J, Serafin, Zbigniew, Zhang, Jeff L, Francis, Susan T, Sourbron, Steven, Pohlmann, Andreas, Fain, Sean B, and Prasad, Pottumarthi V

Subjects
Kidney, Animals, Humans, Magnetic Resonance Imaging, Reproducibility of Results, Consensus, Delphi Technique, Translational Medical Research, Signal-To-Noise Ratio, Biomarkers, Surveys and Questionnaires, BOLD MRI, Imaging, Standardization, Nuclear Medicine & Medical Imaging
Abstract

Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report with the aim to move towards standardized protocols that facilitate clinical translation and comparison of data across sites. We used a recently published systematic review paper, which included a detailed summary of renal BOLD MRI technical parameters and areas of investigation in its supplementary material, as the starting point in developing the survey questionnaires for seeking consensus. Survey data were collected via the Delphi consensus process from 24 researchers on renal BOLD MRI exam preparation, data acquisition, data analysis, and interpretation. Consensus was defined as ≥ 75% unanimity in response. Among 31 survey questions, 14 achieved consensus resolution, 12 showed clear respondent preference (65-74% agreement), and 5 showed equal (50/50%) split in opinion among respondents. Recommendations for subject preparation, data acquisition, processing and reporting are given based on the survey results and review of the literature. These technical recommendations are aimed towards increased inter-site harmonization, a first step towards standardization of renal BOLD MRI protocols across sites. We expect this to be an iterative process updated dynamically based on progress in the field.

Published
2020

5. Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI

Author

Dekkers, Ilona A., de Boer, Anneloes, Sharma, Kaniska, Cox, Eleanor F., Lamb, Hildo J., Buckley, David L., Bane, Octavia, Morris, David M., Prasad, Pottumarthi V., Semple, Scott I. K., Gillis, Keith A., Hockings, Paul, Buchanan, Charlotte, Wolf, Marcos, Laustsen, Christoffer, Leiner, Tim, Haddock, Bryan, Hoogduin, Johannes M., Pullens, Pim, Sourbron, Steven, and Francis, Susan

Published
2020
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6. Consensus-based technical recommendations for clinical translation of renal ASL MRI

Author

Nery, Fabio, Buchanan, Charlotte E., Harteveld, Anita A., Odudu, Aghogho, Bane, Octavia, Cox, Eleanor F., Derlin, Katja, Gach, H. Michael, Golay, Xavier, Gutberlet, Marcel, Laustsen, Christoffer, Ljimani, Alexandra, Madhuranthakam, Ananth J., Pedrosa, Ivan, Prasad, Pottumarthi V., Robson, Philip M., Sharma, Kanishka, Sourbron, Steven, Taso, Manuel, Thomas, David L., Wang, Danny J. J., Zhang, Jeff L., Alsop, David C., Fain, Sean B., Francis, Susan T., and Fernández-Seara, María A.

Published
2020
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9. Protein N-Glycans in Healthy and Sclerotic Glomeruli in Diabetic Kidney Disease

Author

Veličković, Dušan, Shapiro, John P., Parikh, Samir V., Rovin, Brad, Toto, Robert D., Vazquez, Miguel A., Poggio, Emilio D., O'Toole, John F., Sedor, John R., Alexandrov, Theodore, Jain, Sanjay, Bitzer, Markus, Hodgin, Jeffrey, Veličković, Marija, Sharma, Kumar, Anderton, Christopher R., Adeyi, Oyedele A., Alakwaa, Fadhl, Alexandrov, Theodore, Allen, Jamie L., Alpers, Charles E., Alvear, Alison Bunio, Ambekar, Akhil, Ancheta, Joed, Anderton, Christopher R., Angus, Sophia A., Anjani, Kavya, Appelbaum, Paul S., Ardayfio, Joseph, Arora, Tanima, Ascani, Heather K., Asghari, Mahla, El-Achkar, Tarek M., Athar, Humra, Atta, Mohamed G., Aulisio, Mark P., Aw, Stephanie J., Azeloglu, Evren U., Bagne, Cathy A., Balderes, Olivia, Balis, Ulysses G.J., Barasch, Jonathan, Barisoni, Laura, Barwinska, Daria, Basta, Jeannine, Bebiak, Jack, Beck, Laurence H., Berge, Jerica M., Berglund, Ashley C., Bernard, Lauren, Berry, Brooke, Beyda, David H., Bhanushali, Jini Ashok, Bitzer, Markus, Bjornstad, Petter, Blanc, Victoria M., Blank, Kristina N., Bledsoe, Sharon B., Bogen, Steve, Bomback, Andrew S., Bonevich, Nikole, Border, Samuel, Börner, Katy, Bowen, William S., Boys, Charlotte, Bracamonte, Erika R., Bream, Peter R., Brosius, Frank C., Brown, Keith D., Budiman, Tifanny, Bueckle, Andreas, Bui, J.T., James, T., Burg, Ashley R., Burgess, Adam, Bush, Lakeshia, Bush, William S., Cai, Qi, Calixte, Marie Florence, Cameron-Wheeler, Tashas, Campbell, Kirk N, Campbell, Taneisha, Campbell, Catherine, Campos, Baltazar, Canetta, Pietro A., Cantley, Lloyd G, Caramori, M. Luiza, Carmona-Powell, Eunice, Carson, Jonas M, Chan, Lili, Chen, Sarah W, Chen, Yijiang, Cheng, Ying-Hua, Bejarano, Maria Chilo, Choe, Kisurb, Cimino, James G., Coca, Steven G., Coleman, Alyson, Colley, Madeline E., Collie, Mary M., Colona, Mia R., Commander, Clayton W., Conlon, Kristine, Conser, Ninive, Cooperman, Leslie, Corona-Villalobos, Celia P., Crawford, Dana C., Creger, Nathan, Cuevas-Rios, Yarieli, D'Agati, Vivette ., Dagher, Pierre c., de Boer, Ian H., de Caestecker, M.P, de Cos, Marina, Gonçalves, Joana P., Dekker, Matthew, Demeke, Dawit, Dighe, Ashveena L, Ding, Yanli, Djambazova, Katerina V., Donohoe, Isabel, Dowd, Frederick, Drawz, P.E., Dufresne, Martin, Dull, Rachel, Dunn, Kenneth W., Duran, Daniel Damian, Eadon, Michael T, Eddy, Sean, Elder, Michele M, Fallegger, Robin, Farrow, Melissa A, Ferkowicz, Michael, Fine, Derek M., Flanagan, Siobhan M., Fogo, Agnes B., Fox, Monica L., Frey, Renee, Froment, Anne, Gaba, Ron C., Gadegbeku, Crystal A, Gaut, Joseph P., Gehlenborg, Nils, Geraghty, Molly C, Ghag, Reetika, Gilliam, Matthew, Ginley, Brandon, Gisch, Debora, Gordon, Ronald E., Gorman, Brittney L., Greka, Anna, Grewenow, Stephanie M., Gurung, Bhupendra Kumar, Guthrie, Leah, Hacohen, Nir, Haddad, Samuel, Hall, Daniel E., Hansen, Jens, Harindhanavudhi, Tasma, Hartman, John, Hayashi, Lynda, Haydak, Jonathan, He, John Cijiang, He, Yongqun, Hedayati, S. Susan, Henderson, Dori, Henderson, Joel M, Hendricks, Allen R, Henshaw, Asari, Herlitz, Leal, Hernandez, Jeanine, Herr, Bruce W., Himmelfarb, Jonathan, Hodgin, Jeffrey B., Hoofnagle, Andrew N, Horowitz, Carol R., Hsieh, E.W.Y., Huynh, Courtney, Iyengar, Ravi, Jain, Sanjay, Janowczyk, Andrew, Jeffers, Vivian, Jefferson, Nichole M., Jennette, J Charles, Johansen, Camille, Jolly, Stacey, Jones, Christopher J., Jones, Jennifer L., Jones, Kiasha, Joyeux, Cienn N., Ju, Wenjun, Judd, Audra M., Kakade, Vijayakumar R, Kakarla, Dhatri, Kaspari, Rachel R., Kaushal, Madhurima, Keefe, Nicole, Keller, Mark S., Kelley, Sara S., Kellum, John A., Kelly, K. J., Kelly, Tanika N., Kermani, Asra, Kiryluk, Krzysztof, Klett, Susan, Knight, Richard A., Knoten, Amanda, Koch, Gina, Koewler, Robert, Kretzler, Matthias, Kruse, Angela R.S., Küchenhoff, Leonie, Lake, Blue B., Lardenoije, Roy, Larson, Astrid, Larson, Brandon G, Lash, James P., Laszik, Zoltan G., Lecker, Stewart H., Lee, Simon C., Lee, Sora, Lefferts, Sean, Li, Xiang, Lienczewski, Chrysta C, Limonte, Christine P, Lucarelli, Nicholas, Lukowski, Jessica, Lutnick, Brendon, Ma, Shihong, Ma, Sisi, Madabhushi, Anant, Maikhor, Shana, Mao, Weiguang, Mariani, Laura H., Markovic, Marina, Marquez, Nicole, Marshall, Jamie L., McAdams, Meredith C, McClelland, Robyn L., McCown, Phillip J., McMahon, Gearoid Michael, McMurray, Amy, Mehl, Karla, Meliambro, Kristin, Ferreira, Ricardo Melo, Mendoza, Katherine, Menez, Steven, Menon, Rajasree, Meza, Natalie, Migas, Lukasz G., Miller, R. Tyler, Mimar, Sayat, Minor, Brittany C, Mody, Priya, Moeckel, Gilbert W., Moledina, D.G., Molina-Guzman, Jenny, Monroy-Trujillo, Jose M, Morales, Alexander, Moreno, Vanessa, Mottl, Amy K., Mukatash, Tariq, Munar, Dane, Murugan, Raghavan, Nachman, Patrick H., Nadkarni, Girish N, Naglah, Ahmed, Nair, Viji, Nam, Yunbi, Narasimhan, R., Nwanne, Gerald, O'Malley, Charles, O'Toole, John F., Toro, Fernanda Ochoa, Oliver, George (Holt), Onul, Ingrid F, Otto, Edgar A., Palevsky, Paul M., Palmer, Ellen, Pamreddy, Annapurna, Parikh, Chirag R., Parikh, Samir V, Park, Christopher, Park, Harold, Paša-Tolić, Ljiljana, Patel, Jiten, Patel, Marissa, Patlis, Boris S., Paul, Anindya S., Phuong, Jimmy, Pillai, Anil, Pinkeney, Roy, Plisiewicz, Alexa, Poggio, Emilio D, Pollack, Ari, Prasad, Pottumarthi V, Pyle, Laura, Quardokus, Ellen M., Quiroga, Arabela, Ragi, Nagarjunachary, Randhawa, Parmjeet, Randle, Teresa, Rao, Via, Rauchman, Michael, Rauwolf, Nicolas J, Reamy, Rebecca, Record, Elizabeth G., Redmond, Devona, Rennke, Helmut, Renteria, Amada, Rezaei, Kasra A, Rhodes, Rosamond, Ricardo, Ana C., Rice, Samuel, Rivera, Marcelino, Roberts, Glenda V., Rosas, R., Sylvia, E., Rose, Michael P., Rosen, Seymour, Rosenberg, Avi Z., Rosenberg, Michael S., Rosengart, Matthew R., Rovin, Brad H., Roy, Neil, Roy-Chaudhury, Prabir, Rubinsky, Melissa D., Sabo, Angela R., Saez-Rodriguez, Julio, Safadi, Sami, Samari, Imane H., Sanora, Ana Celina, Sarder, Pinaki, Sarkisova, Natalya, Sarwal, Minnie M, Saul, John, Saunders, Milda R., Schaub, Jennifer A., Schmidt, IM, Scott, Raymond, Scroggins, Aaron, Sealfon, Rachel S. G., Sedor, John R., Sendrey, Dianna, Setty, Suman, Shah, Sonya, Shariff, Saad Mohammed, Sharma, Kumar, Shaw, Melissa M., Sigdel, Tara K, Silva, Paolo S., Snyder, Jaime, Snyder, Michelle L., Spates-Harden, Kassandra, Sperati, C. John, Spraggins, Jeffrey M., Srivastava, Anand, Stashevsky, Jennifer, Steck, Becky, Stillman, Isaac E, Stutzke, Christy, Subramanian, Lalita, Sun, Jennifer K., Rajan, Sandhya Sundar, Sutton, Timothy A., Taliercio, Jonathan J, Tan, Roderick, Tanevski, Jovan, Thajudeen, Bijin, Thurman, Joshua M., Tokita, Joji, Torrealba, Jose R., Toto, Robert D, Tout, Haneen, Troyanskaya, Olga G, Tsosie, Rebecca, Turner, Jeffrey M, Tuttle, Katherine R., Ugwuowo, Ugochukwu, Upadhyay, Ashish, Valerius, M. Todd, Van de Plas, Raf, Varela, German, Vazquez, Miguel A., Velickovic, Dusan, Venkatachalam, Manjeri, Verdoes, Abraham, Verma, Ashish, Victoria-Castro, Angela M., Vijayan, Anitha, Villalobos, Alexander, Viloria, Noralinda B., Vinovskis, Carissa, Vita, Tina, Waikar, Sushrut S., Wang, Ashley R., Wang, Bangchen, Wang, Nancy, Wang, Ruikang, Wangperawong, Artit, Ward, Stephen C, Warfield, Curtis, Weins, Astrid, Wen, Natasha, Wen, Yumeng, Wilcox, Adam, Williams, James C., Williams, Kayleen, Williams, Mark E., Wilson, F. Perry, Winfree, Seth, Winters, James, Wofford, Stephanie, Wolf, Susan M., Wong, Aaron, Woodhead, Gregory, Wright, Devin M., Wright, Zach, Wright, Zoe, Wrobel, Julia, Xing, Fuyong, Xu, Alan, Yadati, Pranav, Ye, Hongping, Young, Bessie A., Yu, Guanghao, Mon-Wei Yu, Samuel, Zeinoun, Gabriel, Zeitler, Evan M., Zhang, Bo, Zhang, Guanshi, and Zhang, Yi

Published
2024
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16. Ambulatory Support Moment Contribution Patterns and MRI‐detected Tibiofemoral and Patellofemoral Disease Worsening in Adults with Knee Osteoarthritis:A Preliminary Study

Author

Chang, Alison H., primary, Almagor, Orit, additional, Muhammad, Lutfiyya N., additional, Guermazi, Ali, additional, Prasad, Pottumarthi V., additional, Chmiel, Joan S., additional, Moisio, Kirsten C., additional, Lee, Jungwha (Julia), additional, and Sharma, Leena, additional

Published
2022
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20. Ambulatory support moment contribution patterns and MRI‐detected tibiofemoral and patellofemoral disease worsening in adults with knee osteoarthritis: A preliminary study.

Author

Chang, Alison H., Almagor, Orit, Muhammad, Lutfiyya N., Guermazi, Ali, Prasad, Pottumarthi V., Chmiel, Joan S., Moisio, Kirsten C., Lee, Jungwha, and Sharma, Leena

Subjects
KNEE osteoarthritis, PLICA syndrome, KNEE pain, WALKING speed, BONE marrow, TIBIOFEMORAL joint, ANKLE
Abstract

We investigated whether baseline sagittal‐plane ankle, knee, and hip contribution to the total support moment (TSM) are each associated with baseline‐to‐2‐year tibiofemoral and patellofemoral tissue damage worsening in adults with knee osteoarthritis. Ambulatory lower‐limb kinetics were captured and computed. TSM is the sum of ankle, knee, and hip extensor moments at each instant during gait. Ankle, knee, and hip contributions to TSM were computed as joint moments divided by TSM, expressed as percentages. Participants underwent MRI of both knees at baseline and 2 years later. Logistic regression models assessed associations of baseline ankle contribution to TSM with baseline‐to‐2‐year cartilage damage and bone marrow lesion worsening, adjusted for age, sex, BMI, gait speed, disease severity, and pain. We used similar analytic approaches for knee and hip contributions to TSM. Sample included 391 knees from 204 persons (age[SD]: 64[10] years; 76.5% women). Greater ankle contribution may be associated with increased odds of tibiofemoral cartilage damage worsening (OR = 2.38; 95% CI: 1.02–5.57) and decreased odds of patellofemoral bone marrow lesion worsening (OR = 0.14; 95% CI: 0.03–0.73). The ORs for greater knee contribution were in the protective range for tibiofemoral compartment and in the deleterious range for patellofemoral. Greater hip contribution may be associated with increased odds of tibiofemoral worsening (OR = 2.71; 95% CI: 1.17–6.30). Greater ankle contribution to TSM may be associated with baseline‐to‐2‐year tibiofemoral worsening, but patellofemoral tissue preservation. Conversely, greater knee contribution may be associated with patellofemoral worsening, but tibiofemoral preservation. Preliminary findings illustrate potential challenges in developing biomechanical interventions beneficial to both tibiofemoral and patellofemoral compartments. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Abnormalities in Cardiac Structure and Function among Individuals with CKD: The COMBINE Trial

Author

Wang, Ann A., primary, Cai, Xuan, additional, Srivastava, Anand, additional, Prasad, Pottumarthi V., additional, Sprague, Stuart M., additional, Carr, James, additional, Wolf, Myles, additional, Ix, Joachim H., additional, Block, Geoffrey A., additional, Chonchol, Michel, additional, Raphael, Kalani L., additional, Cheung, Alfred K., additional, Raj, Dominic S., additional, Gassman, Jennifer J., additional, Rahsepar, Amir Ali, additional, Middleton, John P., additional, Fried, Linda F., additional, Sarnari, Roberto, additional, Isakova, Tamara, additional, and Mehta, Rupal, additional

Published
2022
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32. A standard system phantom for magnetic resonance imaging

Author

Stupic, Karl F., primary, Ainslie, Maureen, additional, Boss, Michael A., additional, Charles, Cecil, additional, Dienstfrey, Andrew M., additional, Evelhoch, Jeffrey L., additional, Finn, Paul, additional, Gimbutas, Zydrunas, additional, Gunter, Jeffrey L., additional, Hill, Derek L. G., additional, Jack, Clifford R., additional, Jackson, Edward F., additional, Karaulanov, Todor, additional, Keenan, Kathryn E., additional, Liu, Guoying, additional, Martin, Michele N., additional, Prasad, Pottumarthi V., additional, Rentz, Nikki S., additional, Yuan, Chun, additional, and Russek, Stephen E., additional

Published
2021
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33. Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI

Author

Dekkers, Ilona A, de Boer, Anneloes, Sharma, Kaniska, Cox, Eleanor F, Lamb, Hildo J, Buckley, David L, Bane, Octavia, Morris, David M, Prasad, Pottumarthi V, Semple, Scott I K, Gillis, Keith A, Hockings, Paul, Buchanan, Charlotte, Wolf, Marcos, Laustsen, Christoffer, Leiner, Tim, Haddock, Bryan, Hoogduin, Johannes M, Pullens, Pim, Sourbron, Steven, Francis, Susan, Dekkers, Ilona A, de Boer, Anneloes, Sharma, Kaniska, Cox, Eleanor F, Lamb, Hildo J, Buckley, David L, Bane, Octavia, Morris, David M, Prasad, Pottumarthi V, Semple, Scott I K, Gillis, Keith A, Hockings, Paul, Buchanan, Charlotte, Wolf, Marcos, Laustsen, Christoffer, Leiner, Tim, Haddock, Bryan, Hoogduin, Johannes M, Pullens, Pim, Sourbron, Steven, and Francis, Susan

Published
2020

34. Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI

Author

Researchgr. Cardiovasculaire Radiologie, Circulatory Health, Dekkers, Ilona A, de Boer, Anneloes, Sharma, Kaniska, Cox, Eleanor F, Lamb, Hildo J, Buckley, David L, Bane, Octavia, Morris, David M, Prasad, Pottumarthi V, Semple, Scott I K, Gillis, Keith A, Hockings, Paul, Buchanan, Charlotte, Wolf, Marcos, Laustsen, Christoffer, Leiner, Tim, Haddock, Bryan, Hoogduin, Johannes M, Pullens, Pim, Sourbron, Steven, Francis, Susan, Researchgr. Cardiovasculaire Radiologie, Circulatory Health, Dekkers, Ilona A, de Boer, Anneloes, Sharma, Kaniska, Cox, Eleanor F, Lamb, Hildo J, Buckley, David L, Bane, Octavia, Morris, David M, Prasad, Pottumarthi V, Semple, Scott I K, Gillis, Keith A, Hockings, Paul, Buchanan, Charlotte, Wolf, Marcos, Laustsen, Christoffer, Leiner, Tim, Haddock, Bryan, Hoogduin, Johannes M, Pullens, Pim, Sourbron, Steven, and Francis, Susan

Published
2020

36. Functional MRI of the kidney: tools for translational studies of pathophysiology of renal disease

Author

Prasad, Pottumarthi V.

Subjects
Magnetic resonance imaging -- Usage, Kidneys -- Research, Oxygenators -- Research, Oxygenators, Membrane -- Research, Biological sciences
Abstract

Magnetic resonance imaging (MRI) provides exquisite anatomic detail of various organs and is capable of providing additional functional information. This combination allows for comprehensive diagnostic evaluation of pathologies such as ischemic renal disease. Noninvasive MRI techniques could facilitate translation of many studies performed in controlled animal models using technologies that are invasive to humans. Such a translation is being recognized as essential because many proposed interventions and drugs that prove efficacious in animal models fail to do so in humans. In this article, we review the state-of-the-art functional MRI technique as applied to the kidneys. perfusion; renal function: blood oxygenation level-dependent; human: contrast agent

Published
2006

43. 306-OR: A Metabolic Mismatch between Renal Oxygenation and Glomerular Filtration Rate in Type 1 Diabetes

Author

VINOVSKIS, CARISSA L., primary, NADEAU, KRISTEN J., additional, TOMMERDAHL, KALIE L., additional, PRASAD, POTTUMARTHI V., additional, LI, LU-PING, additional, PYLE, LAURA, additional, REWERS, MARIAN, additional, PRAGNELL, MARLON, additional, MAHMUD, FARID H., additional, VAN RAALTE, DANIËL H., additional, CHERNEY, DAVID, additional, NELSON, ROBERT, additional, and BJORNSTAD, PETTER, additional

Published
2020
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44. Kidney Functional Magnetic Resonance Imaging and Change in eGFR in Individuals with CKD

Author

Srivastava, Anand, primary, Cai, Xuan, additional, Lee, Jungwha, additional, Li, Wei, additional, Larive, Brett, additional, Kendrick, Cynthia, additional, Gassman, Jennifer J., additional, Middleton, John P., additional, Carr, James, additional, Raphael, Kalani L., additional, Cheung, Alfred K., additional, Raj, Dominic S., additional, Chonchol, Michel B., additional, Fried, Linda F., additional, Block, Geoffrey A., additional, Sprague, Stuart M., additional, Wolf, Myles, additional, Ix, Joachim H., additional, Prasad, Pottumarthi V., additional, and Isakova, Tamara, additional

Published
2020
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50. Cortical Perfusion and Tubular Function as Evaluated by MRI Correlate with Annual Loss in Renal Function in Moderate CKD

Author

Prasad, Pottumarthi V., Li, Lu-Ping, Thacker, Jon M., Li, Wei, Hack, Bradley, Kohn, Orly, and Sprague, Stuart M.

Subjects
Magnetic Resonance Spectroscopy, Disease Progression, Humans, Renal Insufficiency, Chronic, urologic and male genital diseases, Magnetic Resonance Imaging, Article
Abstract

BACKGROUND: Chronic hypoxia is a well-recognized factor in the pathogenesis of chronic kidney disease (CKD). Loss of microcirculation is thought to lead to enhanced renal hypoxia which in turn results in the development of fibrosis, a hallmark of progressive CKD. To evaluate the role of functional MRI, we performed perfusion, oxygenation and diffusion MRI measurements in individuals with diabetes and stage 3 CKD. METHODS: Fifty four subjects (41 individuals with diabetes and stage 3 CKD and 13 healthy controls) participated in this study. Data with blood oxygenation level dependent (BOLD), arterial spin labeling (ASL) perfusion and diffusion MRI were acquired using a 3T scanner. RESULTS: Renal cortical perfusion was reduced in CKD compared to the controls (109.54 ± 25.38 vs. 203.17 ± 27.47 ml/min/100gm; p < 0.001). Cortical apparent diffusion coefficient showed no significant reduction in CKD compared to controls (1596.10 ± 196.64 vs. 1668.72 ± 77.29 ×10(−6) mm(2)/s; p = 0.45), but was significantly associated with perfusion. Cortical R2* values were modestly increased in CKD (20.76 ± 4.08 vs. 18.74 ± 2.37 s(−1); p = 0.12). Within the CKD group, R2*_Medulla and R2*_Kidney were moderately and negatively associated with eGFR. There was a significant association between cortical perfusion and medullary response to furosemide with annual loss of renal function, used as an estimate of CKD progression. CONCLUSIONS: Subjects with a moderate degree of CKD had significantly lower renal perfusion. Diffusion and BOLD MRI showed more modest differences between the groups. Individuals with progressive CKD had lower perfusion and response to furosemide.

Published
2019

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