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543 results on '"Prasad, Pottumarthi"'

2. Precision Medicine in Nephrology: An Integrative Framework of Multidimensional Data in the Kidney Precision Medicine Project

Author

Lake, Blue, Zhang, Kun, Lecker, Stewart, Morales, Alexander, Bogen, Steve, Amodu, Afolarin A., Beck, Laurence, Henderson, Joel, Ilori, Titlayo, Maikhor, Shana, Onul, Ingrid, Schmidt, Insa, Verma, Ashish, Waikar, Sushrut, Yadati, Pranav, Yu, Guanghao, Colona, Mia R., McMahon, Gearoid, Hacohen, Nir, Greka, Anna, Hoover, Paul J., Marshall, Jamie L., Aulisio, Mark, Bush, William, Chen, Yijiang, Crawford, Dana, Madabhushi, Anant, Viswanathan, Vidya S., Bush, Lakeshia, Cooperman, Leslie, Gadegbeku, Crystal, Herlitz, Leal, Jolly, Stacey, Nguyen, Jane, O’Malley, Charles, O’Toole, John, Palmer, Ellen, Poggio, Emilio, Spates-Harden, Kassandra, Sedor, John, Sendrey, Dianna, Taliercio, Jonathan, Appelbaum, Paul, Balderes, Olivia, Barasch, Jonathan, Berroue, Cecilia, Bomback, Andrew, Canetta, Pietro A., D’Agati, Vivette, Kiryluk, Krzysztof, Kudose, Satoru, Mehl, Karla, Sabatello, Maya, Shang, Ning, de Pinho Gonçalves, Joana, Lardenoije, Roy, Migas, Lukasz, Van de Plas, Raf, Rennke, Helmut, Azeloglu, Evren, Campbell, Kirk, Coca, Steven, He, Cijang, He, John, Iyengar, Srinivas Ravi, Lefferts, Seanee, Nadkarni, Girish, Patel, Marissa, Tokita, Joji, Ward, Stephen, Xiong, Yuguang, Verdoes, Abraham, Sabo, Angela, Barwinska, Daria, Gisch, Debora Lidia, Williams, James, Kelly, Katherine, Dunn, Kenneth, Asghari, Mahla, Eadon, Michael, Ferkowicz, Michael, Dagher, Pierre, Ferreira, Ricardo Melo, Winfree, Seth, Bledsoe, Sharon, Wofford, Stephanie, El-Achkar, Tarek, Sutton, Timothy, Bowen, William, Cheng, Ying-Hua, Slade, Austen, Record, Elizabeth, Cheng, Yinghua, Borner, Katy, Herr, Bruce, Jain, Yashvardhan, Quardokus, Ellen, Atta, Mohamed, Bernard, Lauren, Menez, Steven, Parikh, Chirag, Corona Villalobos, Celia Pamela, Wang, Ashley, Wen, Yumeng, Xu, Alan, Chen, Sarah, Donohoe, Isabel, Johansen, Camille, Rosas, Sylvia, Sun, Jennifer, Ardayfio, Joseph, Bebiak, Jack, Campbell, Taneisha, Fox, Monica, Knight, Richard, Koewler, Robert, Pinkeney, Roy, Saul, John, Shpigel, Anna, Prasad, Pottumarthi, Madhavan, Sethu M., Parikh, Samir, Rovin, Brad, Shapiro, John P., Anderton, Christopher, Lukowski, Jessica, Pasa-Tolic, Ljiljana, Velickovic, Dusan, Oliver, George, Mao, Weiguang, Sealfon, Rachel, Troyanskaya, Olga, Pollack, Ari, Goltsev, Yury, Ginley, Brandon, Anjani, Kavya, Laszik, Zoltan G., Mukatash, Tariq, Nolan, Garry, Beyda, David, Bracamonte, Erika, Brosius, Frank, Campos, Baltazar, Marquez, Nicole, Mendoza, Katherine, Scott, Raymond, Thajudeen, Bijin, Tsosie, Rebecca, Woodhead, Gregory, Saunders, Milda, Alloway, Rita R., Lee, Paul J., Rike, Adele, Shi, Tiffany, Woodle, E. Steve, Bjornstad, Petter, Hsieh, Elena, Kendrick, Jessica, Pyle, Laura, Thurman, Joshua, Vinovskis, Carissa, Wrobel, Julia, Lucarelli, Nicholas, Sarder, Pinaki, Bui, James, Carmona-Powell; Ron Gaba, Eunice, Kelly, Tanika, Lash, James, Meza, Natalie, Redmond, Devona, Renteria, Amada, Ricardo, Ana, Setty, Suman, Srivastava, Anand, Alakwaa, Fadhl, Ascani, Heather, Balis, Ul, Bitzer, Markus, Blanc, Victoria, Bonevich, Nikki, Conser, Ninive, Demeke, Dawit, Dull, Rachel, Eddy, Sean, Frey, Renee, Hartman, John, He, Yongqun Oliver, Hodgin, Jeffrey, Kretzler, Matthias, Lienczewski, Chrysta, Luo, Jinghui, Mariani, Laura, McCown, Phillip, Menon, Rajasree, Nair, Viji, Otto, Edgar, Reamy, Rebecca, Rose, Michael, Schaub, Jennifer, Steck, Becky, Wright, Zachary, Coleman, Alyson, Henderson-Brown; Jerica Berge, Dorisann, Caramori, Maria Luiza, Adeyi, Oyedele, Nachman, Patrick, Safadi, Sami, Flanagan, Siobhan, Ma, Sisi, Klett, Susan, Wolf, Susan, Harindhanavudhi, Tasma, Rao, Via, Bream, Peter, Froment, Anne, Kelley, Sara, Mottl, Amy, Chaudhury; Evan Zeitler, Prabir Roy, Bender, Filitsa, Elder, Michele, Gilliam, Matthew, Hall, Daniel E., Kellum, John A., Murugan, Raghavan, Palevsky, Paul, Rosengart, Matthew, Tan, Roderick, Tublin, Mitchell, Winters, James, Bansal, Shweta, Montellano, Richard, Pamreddy, Annapurna, Sharma, Kumar, Venkatachalam, Manjeri, Ye, Hongping, Zhang, Guanshi, Basit, Mujeeb, Cai, Qi, Hendricks, Allen, Hedayati, Susan, Kermani, Asra, Lee, Simon C., Ma, Shihong, Miller, Richard Tyler, Moe, Orson W., Park, Harold, Patel, Jiten, Pillai, Anil, Sambandam, Kamalanathan, Torrealba, Jose, Toto, Robert D., Vazquez, Miguel, Wang, Nancy, Wen, Natasha, Zhang, Dianbo, Alpers, Charles, Berglund, Ashley, Berry, Brooke, Blank, Kristina, Brown, Keith, Carson, Jonas, Daniel, Stephen, de Boer, Ian H., Dighe, Ashveena L., Dowd, Frederick, Grewenow, Stephanie M., Himmelfarb, Jonathan, Hoofnagle, Andrew, Jefferson, Nichole, Larson, Brandon, Limonte, Christine, McClelland, Robyn, Mooney, Sean, Nam, Yunbi, Park, Christopher, Phuong, Jimmy, Rezaei, Kasra, Roberts, Glenda, Sarkisova, Natalya, Shankland, Stuart, Snyder, Jaime, Stutzke, Christy, Tuttle, Katherine, Wangperawong, Artit, Wilcox, Adam, Williams, Kayleen, Young, Bessie, Allen, Jamie, Caprioli, Richard M., de Caestecker, Mark, Djambazova, Katerina, Dufresne, Martin, Farrow, Melissa, Fogo, Agnes, Sharman, Kavya, Spraggins, Jeffrey, Basta, Jeannine, Conlon, Kristine, Diettman, Sabine M., Gaut, Joseph, Kaushal, Madhurima, Jain, Sanjay, Knoten, Amanda, Minor, Brittany, Nwanne, Gerald, Vijayan, Anitha, Zhang, Bo, Arora, Tanima, Cantley, Lloyd, Victoria Castro, Angela M., Kakade, Vijayakumar, Moeckel, Gilbert, Moledina, Dennis, Shaw, Melissa, Wilson, Francis P., El-Achkar, Tarek M., and Eadon, Michael T.

Published
2024
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3. Plasma levels of carboxylic acids are markers of early kidney dysfunction in young people with type 1 diabetes

Author

Vigers, Timothy, Vinovskis, Carissa, Li, Lu-Ping, Prasad, Pottumarthi, Heerspink, Hiddo, D'Alessandro, Angelo, and Reisz, Julie A.

Subjects
Type 1 diabetes -- Complications and side effects, Carboxylic acids -- Measurement -- Health aspects -- Physiological aspects, Pediatric research, Diabetic nephropathies -- Risk factors -- Development and progression -- Diagnosis, Health
Abstract

Background We compared plasma metabolites of amino acid oxidation and the tricarboxylic acid (TCA) cycle in youth with and without type 1 diabetes mellitus (T1DM) and related the metabolites to glomerular filtration rate (GFR), renal plasma flow (RPF), and albuminuria. Metabolites associated with impaired kidney function may warrant future study as potential biomarkers or even future interventions to improve kidney bioenergetics. Methods Metabolomic profiling of fasting plasma samples using a targeted panel of 644 metabolites and an untargeted panel of 19,777 metabolites was performed in 50 youth with T1DM [less than or equal to] 10 years and 20 controls. GFR and RPF were ascertained by iohexol and p-aminohippurate clearance, and albuminuria calculated as urine albumin to creatinine ratio. Sparse partial least squares discriminant analysis and moderated t tests were used to identify metabolites associated with GFR and RPF. Results Adolescents with and without T1DM were similar in age (16.1 ± 3.0 vs. 16.1 ± 2.9 years) and BMI (23.4 ± 5.1 vs. 22.7 ± 3.7 kg/m.sup.2), but those with T1DM had higher GFR (189 ± 40 vs. 136 ± 22 ml/min) and RPF (820 ± 125 vs. 615 ± 65 ml/min). Metabolites of amino acid oxidation and the TCA cycle were significantly lower in adolescents with T1DM vs. controls, and the measured metabolites were able to discriminate diabetes status with an AUC of 0.82 (95% CI: 0.71, 0.93) and error rate of 0.21. Lower glycine (r:-0.33, q = 0.01), histidine (r:-0.45, q < 0.001), methionine (r: -0.29, q = 0.02), phenylalanine (r: -0.29, q = 0.01), serine (r: -0.42, q < 0.001), threonine (r: -0.28, q = 0.02), citrate (r: -0.35, q = 0.003), fumarate (r: -0.24, q = 0.04), and malate (r: -0.29, q = 0.02) correlated with higher GFR. Lower glycine (r: -0.28, q = 0.04), phenylalanine (r:-0.3, q = 0.03), fumarate (r: -0.29, q = 0.04), and malate (r: -0.5, q < 0.001) correlated with higher RPF. Lower histidine (r: -0.28, q = 0.02) was correlated with higher mean ACR. Conclusions In conclusion, adolescents with relatively short T1DM duration exhibited lower plasma levels of carboxylic acids that associated with hyperfiltration and hyperperfusion. Trial registration ClinicalTrials.gov NCT03618420 and NCT03584217 Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary information, Author(s): Timothy Vigers [sup.1] [sup.2] , Carissa Vinovskis [sup.1] , Lu-Ping Li [sup.3] , Pottumarthi Prasad [sup.3] , Hiddo Heerspink [sup.4] , Angelo D'Alessandro [sup.5] , Julie A. Reisz [sup.5] [...]

Published
2023
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4. Molecular Signatures of Glomerular Neovascularization in a Patient with Diabetic Kidney Disease

Author

Ferkowicz, Michael J., Verma, Ashish, Barwinska, Daria, Melo Ferreira, Ricardo, Henderson, Joel M., Kirkpatrick, Mary, Silva, Paolo S., Steenkamp, Devin W., Phillips, Carrie L., Waikar, Sushrut S., Sutton, Timothy A., Lake, Blue, Zhang, Kun, Lecker, Stewart, Morales, Alexander, Stillman, Isaac, Bogen, Steve, Amodu, Afolarin A., Beck, Laurence, Henderson, Joel, Ilori, Titlayo, Maikhor, Shana, Onul, Ingrid, Schmidt, Insa, Verma, Ashish, Waikar, Sushrut, Yadati, Pranav, Yu, Guanghao, Colona, Mia R., McMahon, Gearoid, Weins, Astrid, Hacohen, Nir, Greka, Anna, Hoover, Paul J., Marshall, Jamie L., Aulisio, Mark, Bush, William, Chen, Yijiang, Crawford, Dana, Madabhushi, Anant, Viswanathan, Vidya S., Bush, Lakeshia, Cooperman, Leslie, Gadegbeku, Crystal, Herlitz, Leal, Jolly, Stacey, Nguyen, Jane, O’Malley, Charles, O’Toole, John, Palmer, Ellen, Poggio, Emilio, Spates-Harden, Kassandra, Sedor, John, Sendrey, Dianna, Taliercio, Jonathan, Appelbaum, Paul, Balderes, Olivia, Barasch, Jonathan, Berroue, Cecilia, Bomback, Andrew, Canetta, Pietro A., D’Agati, Vivette, Kiryluk, Krzysztof, Kudose, Satoru, Mehl, Karla, Sabatello, Maya, Shang, Ning, Varela, German, de Pinho Gonçalves, Joana, Lardenoije, Roy, Migas, Lukasz, Van de Plas, Raf, Barisoni, Laura, Rennke, Helmut, Azeloglu, Evren, Campbell, Kirk, Coca, Steven, He, Cijang, He, John, Iyengar, Srinivas Ravi, Lefferts, Seanee, Nadkarni, Girish, Patel, Marissa, Tokita, Joji, Ward, Stephen, Xiong, Yuguang, Verdoes, Abraham, Sabo, Angela, Barwinska, Daria, Gisch, Debora Lidia, Williams, James, Kelly, Katherine, Dunn, Kenneth, Asghari, Mahla, Eadon, Michael, Ferkowicz, Michael, Dagher, Pierre, Ferreira, Ricardo Melo, Winfree, Seth, Bledsoe, Sharon, Wofford, Stephanie, El-Achkar, Tarek, Sutton, Timothy, Bowen, William, Cheng, Ying-Hua, Slade, Austen, Record, Elizabeth, Cheng, Yinghua, Borner, Katy, Herr, Bruce, Jain, Yashvardhan, Quardokus, Ellen, Atta, Mohamed, Bernard, Lauren, Menez, Steven, Parikh, Chirag, Corona Villalobos, Celia Pamela, Wang, Ashley, Wen, Yumeng, Xu, Alan, Chen, Sarah, Donohoe, Isabel, Johansen, Camille, Rosas, Sylvia, Sun, Jennifer, Ardayfio, Joseph, Bebiak, Jack, Brown, Keith, Campbell, Taneisha, Fox, Monica, Hayashi, Lynda, Jefferson, Nichole, Richard Knight, Jennifer Jones, Koewler, Robert, Pinkeney, Roy, Saul, John, Shpigel, Anna, Stutzke, Christy, Prasad, Pottumarthi, Madhavan, Sethu M., Parikh, Samir, Rovin, Brad, Shapiro, John P., Anderton, Christopher, Lukowski, Jessica, Pasa-Tolic, Ljiljana, Velickovic, Dusan, Oliver, George, Mao, Weiguang, Sealfon, Rachel, Troyanskaya, Olga, Wong, Aaron, Pollack, Ari, Goltsev, Yury, Ginley, Brandon, Lutnick, Brendon, Anjani, Kavya, Laszik, Zoltan G., Mukatash, Tariq, Nolan, Garry, Beyda, David, Bracamonte, Erika, Brosius, Frank, Campos, Baltazar, Marquez, Nicole, Mendoza, Katherine, Scott, Raymond, Thajudeen, Bijin, Tsosie, Rebecca, Woodhead, Gregory, Saunders, Milda, Alloway, Rita R., Lee, Paul J., Rike, Adele, Shi, Tiffany, Woodle, E. Steve, Bjornstad, Petter, Hsieh, Elena, Kendrick, Jessica, Pyle, Laura, Thurman, Joshua, Vinovskis, Carissa, Wrobel, Julia, Lucarelli, Nicholas, Sarder, Pinaki, Bui, James, Carmona-Powell, Eunice, Gaba, Ron, Kelly, Tanika, Lash, James, Meza, Natalie, Redmond, Devona, Renteria, Amada, Ricardo, Ana, Setty, Suman, Srivastava, Anand, Alakwaa, Fadhl, Ascani, Heather, Balis, Ul, Bitzer, Markus, Blanc, Victoria, Bonevich, Nikki, Conser, Ninive, Demeke, Dawit, Dull, Rachel, Eddy, Sean, Frey, Renee, Hartman, John, He, Yongqun Oliver, Hodgin, Jeffrey, Kretzler, Matthias, Lienczewski, Chrysta, Luo, Jinghui, Mariani, Laura, McCown, Phillip, Menon, Rajasree, Nair, Viji, Otto, Edgar, Reamy, Rebecca, Rose, Michael, Schaub, Jennifer, Steck, Becky, Wright, Zachary, Coleman, Alyson, Henderson-Brown, Dorisann, Berge, Jerica, Caramori, Maria Luiza, Adeyi, Oyedele, Nachman, Patrick, Safadi, Sami, Flanagan, Siobhan, Ma, Sisi, Klett, Susan, Wolf, Susan, Harindhanavudhi, Tasma, Rao, Via, Bream, Peter, Froment, Anne, Kelley, Sara, Mottl, Amy, Roy-Chaudhury, Prabir, Zeitler, Evan, Bender, Filitsa, Elder, Michele, Gilliam, Matthew, Hall, Daniel E., Kellum, John A., Murugan, Raghavan, Palevsky, Paul, Rosengart, Matthew, Tan, Roderick, Tublin, Mitchell, Winters, James, Bansal, Shweta, Montellano, Richard, Pamreddy, Annapurna, Sharma, Kumar, Venkatachalam, Manjeri, Ye, Hongping, Zhang, Guanshi, Basit, Mujeeb, Cai, Qi, Hendricks, Allen, Hedayati, Susan, and Asra

Published
2024
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5. Participant Experience with Protocol Research Kidney Biopsies in the Kidney Precision Medicine Project

Author

Victoria-Castro, Angela M., Corona-Villalobos, Celia P., Xu, Alan Y., Onul, Ingrid, Huynh, Courtney, Chen, Sarah W., Ugwuowo, Ugochukwu, Sarkisova, Natalya, Dighe, Ashveena L., Blank, Kristina N., Blanc, Victoria M., Rose, Michael P., Himmelfarb, Jonathan, de Boer, Ian H., Tuttle, Katherine R., Roberts, Glenda V., Alexandrov, Theodore, Alloway, Rita R., Alpers, Charles E., Amodu, Afolarin A., Anderton, Christopher R., Anjani, Kavya, Appelbaum, Paul, Ardayfio, Joseph, Arora, Tanima, Ascani, Heather, El-Achkar, Tarek M., Aulisio, Mark, Azeloglu, Evren U., Balderes, Olivia, Balis, Ulysses G.J., Bansal, Shweta, Barasch, Jonathan M., Bansal, Shweta, Barkell, Alex, Barwinska, Daria, Basit, Mujeeb, Basta, Jeanine, Bebiak, Jack, Beck, Laurence H., Bender, Filitsa, Berglund, Ashley, Bernard, Lauren, Berrouet, Cecilia, Berry, Brooke, Bjornstad, Petter M., Blanc, Victoria M., Blank, Kristina N., Bledsoe, Sharon, Boada, Patrick, Bogen, Steve, Bomback, Andrew S., Bonevich, Nikole, Borner, Katy, Brown, Keith, Bueckle, Andreas, Burg, Ashley R., Burgess, Adam, Bush, Lakeshia, Bush, William S., Campbell, Catherine E., Campbell, Taneisha, Canetta, Pietro A., Cantley, Lloyd G., Caprioli, Richard M., Carson, Jonas, Chen, Sarah, Chen, Yijiang M., Cheng, Yinghua, Cimino, Jim, Colona, Mia R., Conser, Ninive C., Cooperman, Leslie, Crawford, Dana C., DʼAgati, Vivette D., Dagher, Pierre C., Daniel, Stephen, Daratha, Kenn, de Boer, Ian H., Diettman, Sabine M., Dighe, Ashveena L., Donohoe, Isabel, Dowd, Frederick, Dunn, Kenneth W., Eadon, Michael T., Eddy, Sean, Elder, Michele M., Ferkowicz, Michael J., Frey, Renee, Gadegbeku, Crystal A., Gaut, Joseph P., Gilliam, Matthew, Ginley, Brandon, Gisch, Debora, Goltsev, Yury, Gonzalez-Vicente, Agustin, Greka, Anna, Grewenow, Stephanie M., Hacohen, Nir, Hall, Daniel E., Hansen, Jens, Hayashi, Lynda, He, Cijang, He, Yougqun, Hedayati, S. Susan, Henderson, Joel M., Hendricks, Allen H., Herlitz, Leal, Herr, Bruce W., Himmelfarb, Jonathan, Hodgin, Jeffrey B., Hoofnagle, Andrew N., Hoover, Paul J., Ilori, Titlayo, Iyengar, Ravi, Jain, Sanjay, Jain, Yashvardhan, Janowczyk, Andrew, Jefferson, Nichole, Johansen, Camille, Jolly, Stacey, Kakade, Vijaykumar R., Kellum, John A., Kelly, Katherine J., Kermani, Asra, Kiryluk, Krzysztof, Knight, Richard, Koewler, Robert, Kretzler, Matthias, Kudose, Satoru, Lake, Blue B., Larson, Brandon, Laszik, Zoltan G., Lecker, Stewart H., Lee, Paul J., Lee, Simon C., Lienczewski, Chrysta, Limonte, Christine, Lu, Christopher Y., Lucarelli, Nicholas, Lukowski, Jessica, Luo, Jinghui, Lutnick, Brendon, Ma, Shihong, Madabhushi, Anant, Madhavan, Sethu M., Maikhor, Shana, Mariani, Laura H., Marshall, Jamie L., McClelland, Robyn L., McMahon, Gearoid M., Mehl, Karla, Ferreira, Ricardo Melo, Menez, Steven, Menon, Rajasree, Miller, R. Tyler, Moe, Orson W., Moledina, Dennis, Montellano, Richard, Mooney, Sean D., Morales, Martha Catalina, Mukatash, Tariq, Murugan, Raghavan, Nam, Yunbi, Nguyen, Jane, Nolan, Garry, Oʼtoole, John, Oliver, George (Holt), Onul, Ingrid, Otto, Edgar, Palevsky, Paul M., Palmer, Ellen, Pamreddy, Annapurna, Parikh, Chirag R., Parikh, Samir, Park, Christopher, Park, Harold, Pasa-Tolic, Ljiljana, Patel, Jiten, Patterson, Nathan, Phuong, Jim, Pillai, Anil, Pinkeney, Roy, Poggio, Emilio, Pollack, Ari, Prasad, Pottumarthi, Pyle, Laura, Quardokus, Ellen M., Randhawa, Parmjeet, Rauchman, Michael I., Record, Elizabeth, Rennke, Helmut, Rezaei, Kasra, Rike, Adele, Rivera, Marcelino, Roberts, Glenda V., Rosas, Sylvia E., Rosenberg, Avi, Rosengart, Matthew, Rovin, Brad, Roy, Neil, Sabatello, Maya, Sambandam, Kamalanathan, Sarder, Pinaki, Sarkisova, Natalya, Sarwal, Minnie, Saul, John, Schaub, Jennifer, Schmidt, Insa, Sealfon, Rachel, Sedor, John, Sendrey, Dianna, Shang, Ning, Shankland, Stuart, Shapiro, John P., Sharma, Kumar, Sharman, Kavya, Shaw, Melissa M., Shi, Tiffany, Shpigel, Anna, Sigdel, Tara, Slade, Austen, Snyder, Jamie, Spates-Harden, Kassandra, Spraggins, Jeffrey M., Srivastava, Anand, Steck, Becky, Stillman, Isaac, Stutzke, Christy, Su, Jing, Sun, Jennifer, Sutton, Timothy A., Taliercio, Jonathan, Tan, Roderick, Torrealba, Jose, Toto, Robert D., Troyanskaya, Olga, Tublin, Mitchell, Tuttle, Katherine R., Ugwuowo, Ugochukwu, Valerius, M. Todd, Van de Plas, Raf, Varela, German, Vazquez, Miguel, Velickovic, Dusan, Venkatachalam, Manjeri, Verma, Ashish, Victoria-Castro, Angela M., Vijayan, Anitha, Corona-Villalobos, Celia P., Vinovskis, Carissa, Viswanathan, Vidya S., Vita, Tina, Waikar, Sushrut, Wang, Ashley, Wang, Ruikang, Wang, Nancy, Weins, Astrid, Wen, Natasha, Wen, Yumeng, Wilcox, Adam, Williams, James C., Jr., Kayleen Williams, Williams, Mark, Wilson, Francis P., Winfree, Seth, Winters, James, Wofford, Stephanie, Wong, Aaron, Woodle, E. Steve, Xiong, Yuguang, Xu, Alan, Yadati, Pranav, Ye, Hongping, Yu, Guanghao, Zhang, Dianbo, Zhang, Guanshi, and Zhang, Kun

Published
2024
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6. Consensus-based technical recommendations for clinical translation of renal BOLD MRI.

Author

Bane, Octavia, Mendichovszky, Iosif, Milani, Bastien, Dekkers, Ilona, Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael, Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth, Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Serafin, Zbigniew, Zhang, Jeff, Francis, Susan, Sourbron, Steven, Pohlmann, Andreas, Fain, Sean, Prasad, Pottumarthi, Wang, Zhen, and Liu, Chunlei

Subjects
BOLD MRI, Biomarkers, Consensus, Imaging, Kidney, Standardization, Animals, Biomarkers, Consensus, Delphi Technique, Humans, Kidney, Magnetic Resonance Imaging, Reproducibility of Results, Signal-To-Noise Ratio, Surveys and Questionnaires, Translational Research, Biomedical
Abstract

Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report with the aim to move towards standardized protocols that facilitate clinical translation and comparison of data across sites. We used a recently published systematic review paper, which included a detailed summary of renal BOLD MRI technical parameters and areas of investigation in its supplementary material, as the starting point in developing the survey questionnaires for seeking consensus. Survey data were collected via the Delphi consensus process from 24 researchers on renal BOLD MRI exam preparation, data acquisition, data analysis, and interpretation. Consensus was defined as ≥ 75% unanimity in response. Among 31 survey questions, 14 achieved consensus resolution, 12 showed clear respondent preference (65-74% agreement), and 5 showed equal (50/50%) split in opinion among respondents. Recommendations for subject preparation, data acquisition, processing and reporting are given based on the survey results and review of the literature. These technical recommendations are aimed towards increased inter-site harmonization, a first step towards standardization of renal BOLD MRI protocols across sites. We expect this to be an iterative process updated dynamically based on progress in the field.

Published
2020

7. Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Author

Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, and Sigmund, Eric E

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Biomedical Imaging, Bioengineering, Clinical Research, Algorithms, Biomarkers, Consensus, Delphi Technique, Diffusion Magnetic Resonance Imaging, Humans, Image Interpretation, Computer-Assisted, Kidney, Models, Statistical, Motion, Reproducibility of Results, Surveys and Questionnaires, Translational Research, Biomedical, Biomarker, DWI, ADC, IVIM, DTI, Nuclear Medicine & Medical Imaging
Abstract

ObjectivesStandardization is an important milestone in the validation of DWI-based parameters as imaging biomarkers for renal disease. Here, we propose technical recommendations on three variants of renal DWI, monoexponential DWI, IVIM and DTI, as well as associated MRI biomarkers (ADC, D, D*, f, FA and MD) to aid ongoing international efforts on methodological harmonization.Materials and methodsReported DWI biomarkers from 194 prior renal DWI studies were extracted and Pearson correlations between diffusion biomarkers and protocol parameters were computed. Based on the literature review, surveys were designed for the consensus building. Survey data were collected via Delphi consensus process on renal DWI preparation, acquisition, analysis, and reporting. Consensus was defined as ≥ 75% agreement.ResultsCorrelations were observed between reported diffusion biomarkers and protocol parameters. Out of 87 survey questions, 57 achieved consensus resolution, while many of the remaining questions were resolved by preference (65-74% agreement). Summary of the literature and survey data as well as recommendations for the preparation, acquisition, processing and reporting of renal DWI were provided.DiscussionThe consensus-based technical recommendations for renal DWI aim to facilitate inter-site harmonization and increase clinical impact of the technique on a larger scale by setting a framework for acquisition protocols for future renal DWI studies. We anticipate an iterative process with continuous updating of the recommendations according to progress in the field.

Published
2020

8. Correction to: Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Author

Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, and Sigmund, Eric E

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Nuclear Medicine & Medical Imaging
Abstract

The article Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI.

Published
2020

10. Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis

Author

Knight, Richard, Lecker, Stewart H., Stillman, Isaac, Bogen, Steve, Amodu, Afolarin A., Ilori, Titlayo, Maikhor, Shana, Schmidt, Insa M., Beck, Laurence H., Henderson, Joel M., Onul, Ingrid, Verma, Ashish, McMahon, Gearoid M., Valerius, M. Todd, Waikar, Sushrut, Weins, Astrid, Colona, Mia R., Greka, Anna, Hacohen, Nir, Hoover, Paul J., Marshall, Jamie L., Aulisio, Mark, Chen, Yijiang M., Janowczyk, Andrew, Jayapandian, Catherine, Viswanathan, Vidya S., Bush, William S., Crawford, Dana C., Madabhushi, Anant, Bush, Lakeshia, Cooperman, Leslie, Gonzalez-Vicente, Agustin, Herlitz, Leal, Jolly, Stacey, Nguyen, Jane, O’toole, John, Palmer, Ellen, Poggio, Emilio, Sedor, John, Sendrey, Dianna, Spates-Harden, Kassandra, Taliercio, Jonathan, Bjornstad, Petter M., Pyle, Laura, Vinovskis, Carissa, Appelbaum, Paul, Balderes, Olivia, Barasch, Jonathan M., Bomback, Andrew S., Canetta, Pietro A., D’Agati, Vivette D., Kiryluk, Krzysztof, Kudose, Satoru, Mehl, Karla, Shang, Ning, Bansal, Shweta, Alexandrov, Theodore, Rennke, Helmut, El-Achkar, Tarek M., Barwinska, Daria, Bledso, Sharon, Borner, Katy, Bueckle, Andreas, Cheng, Yinghua, Dagher, Pierre C., Dunn, Kenneth W., Eadon, Michael T., Ferkowicz, Michael J., Herr, Bruce W., Kelly, Katherine J., Ferreira, Ricardo Melo, Quardokus, Ellen M., Record, Elizabeth, Rivera, Marcelino, Su, Jing, Sutton, Timothy A., Williams, James C., Jr., Winfree, Seth, Jain, Yashvardhan, Menez, Steven, Parikh, Chirag R., Rosenberg, Avi, Corona-Villalobos, Celia P., Wen, Yumeng, Johansen, Camille, Rosas, Sylvia E., Roy, Neil, Sun, Jennifer, Williams, Mark, Azeloglu, Evren U., Hansen, Jens, He, Cijang, Iyengar, Ravi, Xiong, Yuguang, Prasad, Pottumarthi, Srivastava, Anand, Madhavan, Sethu M., Parikh, Samir, Rovin, Brad, Shapiro, John P., Anderton, Christopher R., Lukowski, Jessica, Pasa-Tolic, Ljiljana, Velickovic, Dusan, Oliver, George (Holt), Ardayfio, Joseph, Bebiak, Jack, Brown, Keith, Campbell, Taneisha, Campbell, Catherine E., Hayashi, Lynda, Jefferson, Nichole, Roberts, Glenda V., Saul, John, Shpigel, Anna, Stutzke, Christy, Koewler, Robert, Pinkeney, Roy, Sealfon, Rachel, Troyanskaya, Olga, Wong, Aaron, Tuttle, Katherine R., Pollack, Ari, Goltsev, Yury, Ginley, Brandon, Lucarelli, Nicholas, Lutnick, Brendon, Sarder, Pinaki, Lake, Blue B., Zhang, Kun, Boada, Patrick, Laszik, Zoltan G., Nolan, Garry, Anjani, Kavya, Sarwal, Minnie, Mukatash, Tariq, Sigdel, Tara, Alloway, Rita R., Burg, Ashley R., Lee, Paul J., Rike, Adele, Shi, Tiffany, Woodle, E. Steve, Ascani, Heather, Balis, Ulysses G.J., Blanc, Victoria M., Conser, Ninive C., Eddy, Sean, Frey, Renee, He, Yougqun, Hodgin, Jeffrey B., Kretzler, Matthias, Lienczewski, Chrysta, Luo, Jinghui, Mariani, Laura H., Menon, Rajasree, Otto, Edgar, Schaub, Jennifer, Steck, Becky, Elder, Michele M., Gilliam, Matthew, Hall, Daniel E., Murugan, Raghavan, Palevsky, Paul M., Randhawa, Parmjeet, Rosengart, Matthew, Tublin, Mitchell, Vita, Tina, Winters, James, Kellum, John A., Alpers, Charles E., Berglund, Ashley, Berry, Brooke, Blank, Kristina N., Carson, Jonas, Daniel, Stephen, De Boer, Ian H., Dighe, Ashveena L., Dowd, Frederick, Grewenow, Stephanie M., Himmelfarb, Jonathan, Hoofnagle, Andrew N., Limonte, Christine, McClelland, Robyn L., Mooney, Sean D., Rezaei, Kasra, Shankland, Stuart, Snyder, Jamie, Wang, Ruikang, Wilcox, Adam, Williams, Kayleen, Park, Christopher, Montellano, Richard, Pamreddy, Annapurna, Sharma, Kumar, Venkatachalam, Manjeri, Ye, Hongping, Zhang, Guanshi, Basit, Mujeeb, Hedayati, S. Susan, Kermani, Asra, Lee, Simon C., Lu, Christopher Y., Miller, R. Tyler, Moe, Orson W., Patel, Jiten, Pillai, Anil, Sambandam, Kamalanathan, Torrealba, Jose, Toto, Robert D., Vazquez, Miguel, Wang, Nancy, Wen, Natasha, Zhang, Dianbo, Park, Harold, Caprioli, Richard M., Patterson, Nathan, Sharman, Kavya, Spraggins, Jeffrey M., Van de Plas, Raf, Basta, Jeanine, Diettman, Sabine M., Gaut, Joseph P., Jain, Sanjay, Rauchman, Michael I., Vijayan, Anitha, Cantley, Lloyd G., Kakade, Vijaykumar R., Moledina, Dennis, Shaw, Melissa M., Ugwuowo, Ugochukwu, Wilson, Francis P., Arora, Tanima, Kestenbaum, Bryan R., Alexopoulos, Leonidas G., Palsson, Ragnar, Liu, Jing, Stillman, Isaac E., Rennke, Helmut G., Vaidya, Vishal S., Wu, Haojia, Humphreys, Benjamin D., and Waikar, Sushrut S.

Published
2021
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12. Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI

Author

Dekkers, Ilona A., de Boer, Anneloes, Sharma, Kaniska, Cox, Eleanor F., Lamb, Hildo J., Buckley, David L., Bane, Octavia, Morris, David M., Prasad, Pottumarthi V., Semple, Scott I. K., Gillis, Keith A., Hockings, Paul, Buchanan, Charlotte, Wolf, Marcos, Laustsen, Christoffer, Leiner, Tim, Haddock, Bryan, Hoogduin, Johannes M., Pullens, Pim, Sourbron, Steven, and Francis, Susan

Published
2020
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14. Consensus-based technical recommendations for clinical translation of renal ASL MRI

Author

Nery, Fabio, Buchanan, Charlotte E., Harteveld, Anita A., Odudu, Aghogho, Bane, Octavia, Cox, Eleanor F., Derlin, Katja, Gach, H. Michael, Golay, Xavier, Gutberlet, Marcel, Laustsen, Christoffer, Ljimani, Alexandra, Madhuranthakam, Ananth J., Pedrosa, Ivan, Prasad, Pottumarthi V., Robson, Philip M., Sharma, Kanishka, Sourbron, Steven, Taso, Manuel, Thomas, David L., Wang, Danny J. J., Zhang, Jeff L., Alsop, David C., Fain, Sean B., Francis, Susan T., and Fernández-Seara, María A.

Published
2020
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15. Technical recommendations for clinical translation of renal MRI: a consensus project of the Cooperation in Science and Technology Action PARENCHIMA

Author

Mendichovszky, Iosif, Pullens, Pim, Dekkers, Ilona, Nery, Fabio, Bane, Octavia, Pohlmann, Andreas, de Boer, Anneloes, Ljimani, Alexandra, Odudu, Aghogho, Buchanan, Charlotte, Sharma, Kanishka, Laustsen, Christoffer, Harteveld, Anita, Golay, Xavier, Pedrosa, Ivan, Alsop, David, Fain, Sean, Caroli, Anna, Prasad, Pottumarthi, Francis, Susan, Sigmund, Eric, Fernández‐Seara, Maria, and Sourbron, Steven

Published
2020
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18. Protein N-Glycans in Healthy and Sclerotic Glomeruli in Diabetic Kidney Disease

Author

Veličković, Dušan, Shapiro, John P., Parikh, Samir V., Rovin, Brad, Toto, Robert D., Vazquez, Miguel A., Poggio, Emilio D., O'Toole, John F., Sedor, John R., Alexandrov, Theodore, Jain, Sanjay, Bitzer, Markus, Hodgin, Jeffrey, Veličković, Marija, Sharma, Kumar, Anderton, Christopher R., Adeyi, Oyedele A., Alakwaa, Fadhl, Alexandrov, Theodore, Allen, Jamie L., Alpers, Charles E., Alvear, Alison Bunio, Ambekar, Akhil, Ancheta, Joed, Anderton, Christopher R., Angus, Sophia A., Anjani, Kavya, Appelbaum, Paul S., Ardayfio, Joseph, Arora, Tanima, Ascani, Heather K., Asghari, Mahla, El-Achkar, Tarek M., Athar, Humra, Atta, Mohamed G., Aulisio, Mark P., Aw, Stephanie J., Azeloglu, Evren U., Bagne, Cathy A., Balderes, Olivia, Balis, Ulysses G.J., Barasch, Jonathan, Barisoni, Laura, Barwinska, Daria, Basta, Jeannine, Bebiak, Jack, Beck, Laurence H., Berge, Jerica M., Berglund, Ashley C., Bernard, Lauren, Berry, Brooke, Beyda, David H., Bhanushali, Jini Ashok, Bitzer, Markus, Bjornstad, Petter, Blanc, Victoria M., Blank, Kristina N., Bledsoe, Sharon B., Bogen, Steve, Bomback, Andrew S., Bonevich, Nikole, Border, Samuel, Börner, Katy, Bowen, William S., Boys, Charlotte, Bracamonte, Erika R., Bream, Peter R., Brosius, Frank C., Brown, Keith D., Budiman, Tifanny, Bueckle, Andreas, Bui, J.T., James, T., Burg, Ashley R., Burgess, Adam, Bush, Lakeshia, Bush, William S., Cai, Qi, Calixte, Marie Florence, Cameron-Wheeler, Tashas, Campbell, Kirk N, Campbell, Taneisha, Campbell, Catherine, Campos, Baltazar, Canetta, Pietro A., Cantley, Lloyd G, Caramori, M. Luiza, Carmona-Powell, Eunice, Carson, Jonas M, Chan, Lili, Chen, Sarah W, Chen, Yijiang, Cheng, Ying-Hua, Bejarano, Maria Chilo, Choe, Kisurb, Cimino, James G., Coca, Steven G., Coleman, Alyson, Colley, Madeline E., Collie, Mary M., Colona, Mia R., Commander, Clayton W., Conlon, Kristine, Conser, Ninive, Cooperman, Leslie, Corona-Villalobos, Celia P., Crawford, Dana C., Creger, Nathan, Cuevas-Rios, Yarieli, D'Agati, Vivette ., Dagher, Pierre c., de Boer, Ian H., de Caestecker, M.P, de Cos, Marina, Gonçalves, Joana P., Dekker, Matthew, Demeke, Dawit, Dighe, Ashveena L, Ding, Yanli, Djambazova, Katerina V., Donohoe, Isabel, Dowd, Frederick, Drawz, P.E., Dufresne, Martin, Dull, Rachel, Dunn, Kenneth W., Duran, Daniel Damian, Eadon, Michael T, Eddy, Sean, Elder, Michele M, Fallegger, Robin, Farrow, Melissa A, Ferkowicz, Michael, Fine, Derek M., Flanagan, Siobhan M., Fogo, Agnes B., Fox, Monica L., Frey, Renee, Froment, Anne, Gaba, Ron C., Gadegbeku, Crystal A, Gaut, Joseph P., Gehlenborg, Nils, Geraghty, Molly C, Ghag, Reetika, Gilliam, Matthew, Ginley, Brandon, Gisch, Debora, Gordon, Ronald E., Gorman, Brittney L., Greka, Anna, Grewenow, Stephanie M., Gurung, Bhupendra Kumar, Guthrie, Leah, Hacohen, Nir, Haddad, Samuel, Hall, Daniel E., Hansen, Jens, Harindhanavudhi, Tasma, Hartman, John, Hayashi, Lynda, Haydak, Jonathan, He, John Cijiang, He, Yongqun, Hedayati, S. Susan, Henderson, Dori, Henderson, Joel M, Hendricks, Allen R, Henshaw, Asari, Herlitz, Leal, Hernandez, Jeanine, Herr, Bruce W., Himmelfarb, Jonathan, Hodgin, Jeffrey B., Hoofnagle, Andrew N, Horowitz, Carol R., Hsieh, E.W.Y., Huynh, Courtney, Iyengar, Ravi, Jain, Sanjay, Janowczyk, Andrew, Jeffers, Vivian, Jefferson, Nichole M., Jennette, J Charles, Johansen, Camille, Jolly, Stacey, Jones, Christopher J., Jones, Jennifer L., Jones, Kiasha, Joyeux, Cienn N., Ju, Wenjun, Judd, Audra M., Kakade, Vijayakumar R, Kakarla, Dhatri, Kaspari, Rachel R., Kaushal, Madhurima, Keefe, Nicole, Keller, Mark S., Kelley, Sara S., Kellum, John A., Kelly, K. J., Kelly, Tanika N., Kermani, Asra, Kiryluk, Krzysztof, Klett, Susan, Knight, Richard A., Knoten, Amanda, Koch, Gina, Koewler, Robert, Kretzler, Matthias, Kruse, Angela R.S., Küchenhoff, Leonie, Lake, Blue B., Lardenoije, Roy, Larson, Astrid, Larson, Brandon G, Lash, James P., Laszik, Zoltan G., Lecker, Stewart H., Lee, Simon C., Lee, Sora, Lefferts, Sean, Li, Xiang, Lienczewski, Chrysta C, Limonte, Christine P, Lucarelli, Nicholas, Lukowski, Jessica, Lutnick, Brendon, Ma, Shihong, Ma, Sisi, Madabhushi, Anant, Maikhor, Shana, Mao, Weiguang, Mariani, Laura H., Markovic, Marina, Marquez, Nicole, Marshall, Jamie L., McAdams, Meredith C, McClelland, Robyn L., McCown, Phillip J., McMahon, Gearoid Michael, McMurray, Amy, Mehl, Karla, Meliambro, Kristin, Ferreira, Ricardo Melo, Mendoza, Katherine, Menez, Steven, Menon, Rajasree, Meza, Natalie, Migas, Lukasz G., Miller, R. Tyler, Mimar, Sayat, Minor, Brittany C, Mody, Priya, Moeckel, Gilbert W., Moledina, D.G., Molina-Guzman, Jenny, Monroy-Trujillo, Jose M, Morales, Alexander, Moreno, Vanessa, Mottl, Amy K., Mukatash, Tariq, Munar, Dane, Murugan, Raghavan, Nachman, Patrick H., Nadkarni, Girish N, Naglah, Ahmed, Nair, Viji, Nam, Yunbi, Narasimhan, R., Nwanne, Gerald, O'Malley, Charles, O'Toole, John F., Toro, Fernanda Ochoa, Oliver, George (Holt), Onul, Ingrid F, Otto, Edgar A., Palevsky, Paul M., Palmer, Ellen, Pamreddy, Annapurna, Parikh, Chirag R., Parikh, Samir V, Park, Christopher, Park, Harold, Paša-Tolić, Ljiljana, Patel, Jiten, Patel, Marissa, Patlis, Boris S., Paul, Anindya S., Phuong, Jimmy, Pillai, Anil, Pinkeney, Roy, Plisiewicz, Alexa, Poggio, Emilio D, Pollack, Ari, Prasad, Pottumarthi V, Pyle, Laura, Quardokus, Ellen M., Quiroga, Arabela, Ragi, Nagarjunachary, Randhawa, Parmjeet, Randle, Teresa, Rao, Via, Rauchman, Michael, Rauwolf, Nicolas J, Reamy, Rebecca, Record, Elizabeth G., Redmond, Devona, Rennke, Helmut, Renteria, Amada, Rezaei, Kasra A, Rhodes, Rosamond, Ricardo, Ana C., Rice, Samuel, Rivera, Marcelino, Roberts, Glenda V., Rosas, R., Sylvia, E., Rose, Michael P., Rosen, Seymour, Rosenberg, Avi Z., Rosenberg, Michael S., Rosengart, Matthew R., Rovin, Brad H., Roy, Neil, Roy-Chaudhury, Prabir, Rubinsky, Melissa D., Sabo, Angela R., Saez-Rodriguez, Julio, Safadi, Sami, Samari, Imane H., Sanora, Ana Celina, Sarder, Pinaki, Sarkisova, Natalya, Sarwal, Minnie M, Saul, John, Saunders, Milda R., Schaub, Jennifer A., Schmidt, IM, Scott, Raymond, Scroggins, Aaron, Sealfon, Rachel S. G., Sedor, John R., Sendrey, Dianna, Setty, Suman, Shah, Sonya, Shariff, Saad Mohammed, Sharma, Kumar, Shaw, Melissa M., Sigdel, Tara K, Silva, Paolo S., Snyder, Jaime, Snyder, Michelle L., Spates-Harden, Kassandra, Sperati, C. John, Spraggins, Jeffrey M., Srivastava, Anand, Stashevsky, Jennifer, Steck, Becky, Stillman, Isaac E, Stutzke, Christy, Subramanian, Lalita, Sun, Jennifer K., Rajan, Sandhya Sundar, Sutton, Timothy A., Taliercio, Jonathan J, Tan, Roderick, Tanevski, Jovan, Thajudeen, Bijin, Thurman, Joshua M., Tokita, Joji, Torrealba, Jose R., Toto, Robert D, Tout, Haneen, Troyanskaya, Olga G, Tsosie, Rebecca, Turner, Jeffrey M, Tuttle, Katherine R., Ugwuowo, Ugochukwu, Upadhyay, Ashish, Valerius, M. Todd, Van de Plas, Raf, Varela, German, Vazquez, Miguel A., Velickovic, Dusan, Venkatachalam, Manjeri, Verdoes, Abraham, Verma, Ashish, Victoria-Castro, Angela M., Vijayan, Anitha, Villalobos, Alexander, Viloria, Noralinda B., Vinovskis, Carissa, Vita, Tina, Waikar, Sushrut S., Wang, Ashley R., Wang, Bangchen, Wang, Nancy, Wang, Ruikang, Wangperawong, Artit, Ward, Stephen C, Warfield, Curtis, Weins, Astrid, Wen, Natasha, Wen, Yumeng, Wilcox, Adam, Williams, James C., Williams, Kayleen, Williams, Mark E., Wilson, F. Perry, Winfree, Seth, Winters, James, Wofford, Stephanie, Wolf, Susan M., Wong, Aaron, Woodhead, Gregory, Wright, Devin M., Wright, Zach, Wright, Zoe, Wrobel, Julia, Xing, Fuyong, Xu, Alan, Yadati, Pranav, Ye, Hongping, Young, Bessie A., Yu, Guanghao, Mon-Wei Yu, Samuel, Zeinoun, Gabriel, Zeitler, Evan M., Zhang, Bo, Zhang, Guanshi, and Zhang, Yi

Published
2024
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19. Insulin secretion, sensitivity, and kidney function in young persons with type 2 diabetes

Author

Bjornstad, Petter, primary, Ji Choi, Ye, primary, Platnick, Carson, primary, Gross, Susan, primary, Narongkiatikhun, Phoom, primary, Melena, Isabella, primary, Remmers, Lauryn, primary, Baca, Mayra, primary, Schutte, Grant, primary, Dobbs, Tyler, primary, Vigers, Tim, primary, Pyle, Laura, primary, Driscoll, Lynette, primary, Tommerdahl, Kalie, primary, Kendrick, Jessica, primary, C Looker, Helen, primary, Dart, Allison, primary, Cherney, David, primary, H van Raalte, Daniel, primary, Srivastava, Anand, primary, Li, Luping, primary, Prasad, Pottumarthi, primary, Saulnier, Pierre, primary, G Nelson, Robert, primary, J Johnson, Richard, primary, and J Nadeau, Kristen, primary

Published
2023
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24. A multimodal neural network that distinguishes between type 1 and type 2 diabetes in young persons using MRI and clinical data

Author

Mehrshad Sadria, Petter Bjornstad, Prasad Pottumarthi, Li Lu-Ping, Laura Pyle, Timothy Vigers, and Anita Layton

Subjects
Physiology
Abstract

Early diabetic kidney disease (DKD) is common in young persons with type 1 (T1D) and type 2 diabetes (T2D) and accentuates their lifetime risk of kidney failure, requiring dialysis or a kidney transplant. Although clinical manifestations of DKD are similar in T1D and T2D, the structural lesions may differ, and it remains unclear whether DKD in T1D and T2D represent distinct diseases. Accordingly, the objective of this study is to build machine learning (ML) models using clinical and kidney MRI data to classify diabetes status, as well as structural and functional kidney differences of individuals with T1D versus T2D. We hypothesize that a highly accurate multimodal neural network can be constructed that integrates clinical and functional kidney MRI images.Data were obtained from several studies at University of Colorado in youth with T1D (n=102), T2D (n=91) as well as non-diabetic controls (n=60). A total of 253 participants were included in the analyses. First, we applied to clinical data (CASPER, IMPROVE-T2D, CROCODILE, and RENAL-HEIR trials) logistic regression and 7 ML models: extreme gradient boosting machine (XGBoost), XGBoost with grid search, k-nearest neighbors (KNN), support vector machine (SVM), decision tree, random forest, and a 3-layer neural network (NN-EHR). When a small subset of the clinical data was used as features, the NN-EHR yielded the highest accuracy of 84%. Next, we considered the MRI images (27,000 images from the 253 individuals). We applied three convoluted NN to perform the classification: AlexNet, VGG16, and a 4-layer Neural Network for Diabetes Detection (NN4DD). Considering the images alone, VGG16 and NN4DD both achieved an accuracy of > 80%. Additionally, by integrating the clinical data and the MRI images, the fusion neural network achieved an accuracy of almost 100%. Finally, an interpretability analysis of NN4DD indicated notable differences in kidney structure and function among the three groups.Although the cost of MRI is prohibitive and thus impractical for diabetes diagnosis, these results provide a proof-of-concept that fused neural networks that integrate multimodal data can be a valuable diagnostic tool, and provide structural and functional insight on kidney differences between T1D and T2D. This research is sponsored in part by the Natural Sciences and Engineering Council (Canada) and the National Institutes of Health (USA). This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Published
2023
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28. Ambulatory Support Moment Contribution Patterns and MRI‐detected Tibiofemoral and Patellofemoral Disease Worsening in Adults with Knee Osteoarthritis:A Preliminary Study

Author

Chang, Alison H., primary, Almagor, Orit, additional, Muhammad, Lutfiyya N., additional, Guermazi, Ali, additional, Prasad, Pottumarthi V., additional, Chmiel, Joan S., additional, Moisio, Kirsten C., additional, Lee, Jungwha (Julia), additional, and Sharma, Leena, additional

Published
2022
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31. The Evaluation of Coffee Therapy for Improvement of Renal Oxygenation (COFFEE) Study: A Mechanistic Pilot and Feasibility Study Evaluating Coffee’s Effects on Intrarenal Hemodynamic Function and Renal Energetics

Author

Tommerdahl, Kalie L., primary, Vinovskis, Carissa, additional, Li, Lu-Ping, additional, Rebholz, Casey M., additional, Severn, Cameron, additional, Hu, Emily A., additional, Selvin, Elizabeth, additional, Coresh, Josef, additional, Grams, Morgan E., additional, Prasad, Pottumarthi, additional, Parikh, Chirag R., additional, and Bjornstad, Petter, additional

Published
2022
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33. Ambulatory support moment contribution patterns and MRI‐detected tibiofemoral and patellofemoral disease worsening in adults with knee osteoarthritis: A preliminary study.

Author

Chang, Alison H., Almagor, Orit, Muhammad, Lutfiyya N., Guermazi, Ali, Prasad, Pottumarthi V., Chmiel, Joan S., Moisio, Kirsten C., Lee, Jungwha, and Sharma, Leena

Subjects
KNEE osteoarthritis, PLICA syndrome, KNEE pain, WALKING speed, BONE marrow, TIBIOFEMORAL joint, ANKLE
Abstract

We investigated whether baseline sagittal‐plane ankle, knee, and hip contribution to the total support moment (TSM) are each associated with baseline‐to‐2‐year tibiofemoral and patellofemoral tissue damage worsening in adults with knee osteoarthritis. Ambulatory lower‐limb kinetics were captured and computed. TSM is the sum of ankle, knee, and hip extensor moments at each instant during gait. Ankle, knee, and hip contributions to TSM were computed as joint moments divided by TSM, expressed as percentages. Participants underwent MRI of both knees at baseline and 2 years later. Logistic regression models assessed associations of baseline ankle contribution to TSM with baseline‐to‐2‐year cartilage damage and bone marrow lesion worsening, adjusted for age, sex, BMI, gait speed, disease severity, and pain. We used similar analytic approaches for knee and hip contributions to TSM. Sample included 391 knees from 204 persons (age[SD]: 64[10] years; 76.5% women). Greater ankle contribution may be associated with increased odds of tibiofemoral cartilage damage worsening (OR = 2.38; 95% CI: 1.02–5.57) and decreased odds of patellofemoral bone marrow lesion worsening (OR = 0.14; 95% CI: 0.03–0.73). The ORs for greater knee contribution were in the protective range for tibiofemoral compartment and in the deleterious range for patellofemoral. Greater hip contribution may be associated with increased odds of tibiofemoral worsening (OR = 2.71; 95% CI: 1.17–6.30). Greater ankle contribution to TSM may be associated with baseline‐to‐2‐year tibiofemoral worsening, but patellofemoral tissue preservation. Conversely, greater knee contribution may be associated with patellofemoral worsening, but tibiofemoral preservation. Preliminary findings illustrate potential challenges in developing biomechanical interventions beneficial to both tibiofemoral and patellofemoral compartments. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Plasma levels of carboxylic acids are markers of early kidney dysfunction in young people with type 1 diabetes

Author

Vigers, Timothy, primary, Vinovskis, Carissa, additional, Li, Lu-Ping, additional, Prasad, Pottumarthi, additional, Heerspink, Hiddo, additional, D’Alessandro, Angelo, additional, Reisz, Julie A., additional, Piani, Federica, additional, Cherney, David Z., additional, van Raalte, Daniel H., additional, Nadeau, Kristen J., additional, Pavkov, Meda E., additional, Nelson, Robert G., additional, Pyle, Laura, additional, and Bjornstad, Petter, additional

Published
2022
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39. Abnormalities in Cardiac Structure and Function among Individuals with CKD: The COMBINE Trial

Author

Wang, Ann A., primary, Cai, Xuan, additional, Srivastava, Anand, additional, Prasad, Pottumarthi V., additional, Sprague, Stuart M., additional, Carr, James, additional, Wolf, Myles, additional, Ix, Joachim H., additional, Block, Geoffrey A., additional, Chonchol, Michel, additional, Raphael, Kalani L., additional, Cheung, Alfred K., additional, Raj, Dominic S., additional, Gassman, Jennifer J., additional, Rahsepar, Amir Ali, additional, Middleton, John P., additional, Fried, Linda F., additional, Sarnari, Roberto, additional, Isakova, Tamara, additional, and Mehta, Rupal, additional

Published
2022
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42. Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis

Author

Schmidt, Insa M., primary, Colona, Mia R., additional, Kestenbaum, Bryan R., additional, Alexopoulos, Leonidas G., additional, Palsson, Ragnar, additional, Srivastava, Anand, additional, Liu, Jing, additional, Stillman, Isaac E., additional, Rennke, Helmut G., additional, Vaidya, Vishal S., additional, Wu, Haojia, additional, Humphreys, Benjamin D., additional, Waikar, Sushrut S., additional, Knight, Richard, additional, Lecker, Stewart H., additional, Stillman, Isaac, additional, Bogen, Steve, additional, Amodu, Afolarin A., additional, Ilori, Titlayo, additional, Maikhor, Shana, additional, Schmidt, Insa M., additional, Beck, Laurence H., additional, Henderson, Joel M., additional, Onul, Ingrid, additional, Verma, Ashish, additional, McMahon, Gearoid M., additional, Valerius, M. Todd, additional, Waikar, Sushrut, additional, Weins, Astrid, additional, Greka, Anna, additional, Hacohen, Nir, additional, Hoover, Paul J., additional, Marshall, Jamie L., additional, Aulisio, Mark, additional, Chen, Yijiang M., additional, Janowczyk, Andrew, additional, Jayapandian, Catherine, additional, Viswanathan, Vidya S., additional, Bush, William S., additional, Crawford, Dana C., additional, Madabhushi, Anant, additional, Bush, Lakeshia, additional, Cooperman, Leslie, additional, Gonzalez-Vicente, Agustin, additional, Herlitz, Leal, additional, Jolly, Stacey, additional, Nguyen, Jane, additional, O’toole, John, additional, Palmer, Ellen, additional, Poggio, Emilio, additional, Sedor, John, additional, Sendrey, Dianna, additional, Spates-Harden, Kassandra, additional, Taliercio, Jonathan, additional, Bjornstad, Petter M., additional, Pyle, Laura, additional, Vinovskis, Carissa, additional, Appelbaum, Paul, additional, Balderes, Olivia, additional, Barasch, Jonathan M., additional, Bomback, Andrew S., additional, Canetta, Pietro A., additional, D’Agati, Vivette D., additional, Kiryluk, Krzysztof, additional, Kudose, Satoru, additional, Mehl, Karla, additional, Shang, Ning, additional, Bansal, Shweta, additional, Alexandrov, Theodore, additional, Rennke, Helmut, additional, El-Achkar, Tarek M., additional, Barwinska, Daria, additional, Bledso, Sharon, additional, Borner, Katy, additional, Bueckle, Andreas, additional, Cheng, Yinghua, additional, Dagher, Pierre C., additional, Dunn, Kenneth W., additional, Eadon, Michael T., additional, Ferkowicz, Michael J., additional, Herr, Bruce W., additional, Kelly, Katherine J., additional, Ferreira, Ricardo Melo, additional, Quardokus, Ellen M., additional, Record, Elizabeth, additional, Rivera, Marcelino, additional, Su, Jing, additional, Sutton, Timothy A., additional, Williams, James C., additional, Winfree, Seth, additional, Jain, Yashvardhan, additional, Menez, Steven, additional, Parikh, Chirag R., additional, Rosenberg, Avi, additional, Corona-Villalobos, Celia P., additional, Wen, Yumeng, additional, Johansen, Camille, additional, Rosas, Sylvia E., additional, Roy, Neil, additional, Sun, Jennifer, additional, Williams, Mark, additional, Azeloglu, Evren U., additional, Hansen, Jens, additional, He, Cijang, additional, Iyengar, Ravi, additional, Xiong, Yuguang, additional, Prasad, Pottumarthi, additional, Madhavan, Sethu M., additional, Parikh, Samir, additional, Rovin, Brad, additional, Shapiro, John P., additional, Anderton, Christopher R., additional, Lukowski, Jessica, additional, Pasa-Tolic, Ljiljana, additional, Velickovic, Dusan, additional, Oliver, George (Holt), additional, Ardayfio, Joseph, additional, Bebiak, Jack, additional, Brown, Keith, additional, Campbell, Taneisha, additional, Campbell, Catherine E., additional, Hayashi, Lynda, additional, Jefferson, Nichole, additional, Roberts, Glenda V., additional, Saul, John, additional, Shpigel, Anna, additional, Stutzke, Christy, additional, Koewler, Robert, additional, Pinkeney, Roy, additional, Sealfon, Rachel, additional, Troyanskaya, Olga, additional, Wong, Aaron, additional, Tuttle, Katherine R., additional, Pollack, Ari, additional, Goltsev, Yury, additional, Ginley, Brandon, additional, Lucarelli, Nicholas, additional, Lutnick, Brendon, additional, Sarder, Pinaki, additional, Lake, Blue B., additional, Zhang, Kun, additional, Boada, Patrick, additional, Laszik, Zoltan G., additional, Nolan, Garry, additional, Anjani, Kavya, additional, Sarwal, Minnie, additional, Mukatash, Tariq, additional, Sigdel, Tara, additional, Alloway, Rita R., additional, Burg, Ashley R., additional, Lee, Paul J., additional, Rike, Adele, additional, Shi, Tiffany, additional, Woodle, E. Steve, additional, Ascani, Heather, additional, Balis, Ulysses G.J., additional, Blanc, Victoria M., additional, Conser, Ninive C., additional, Eddy, Sean, additional, Frey, Renee, additional, He, Yougqun, additional, Hodgin, Jeffrey B., additional, Kretzler, Matthias, additional, Lienczewski, Chrysta, additional, Luo, Jinghui, additional, Mariani, Laura H., additional, Menon, Rajasree, additional, Otto, Edgar, additional, Schaub, Jennifer, additional, Steck, Becky, additional, Elder, Michele M., additional, Gilliam, Matthew, additional, Hall, Daniel E., additional, Murugan, Raghavan, additional, Palevsky, Paul M., additional, Randhawa, Parmjeet, additional, Rosengart, Matthew, additional, Tublin, Mitchell, additional, Vita, Tina, additional, Winters, James, additional, Kellum, John A., additional, Alpers, Charles E., additional, Berglund, Ashley, additional, Berry, Brooke, additional, Blank, Kristina N., additional, Carson, Jonas, additional, Daniel, Stephen, additional, De Boer, Ian H., additional, Dighe, Ashveena L., additional, Dowd, Frederick, additional, Grewenow, Stephanie M., additional, Himmelfarb, Jonathan, additional, Hoofnagle, Andrew N., additional, Limonte, Christine, additional, McClelland, Robyn L., additional, Mooney, Sean D., additional, Rezaei, Kasra, additional, Shankland, Stuart, additional, Snyder, Jamie, additional, Wang, Ruikang, additional, Wilcox, Adam, additional, Williams, Kayleen, additional, Park, Christopher, additional, Montellano, Richard, additional, Pamreddy, Annapurna, additional, Sharma, Kumar, additional, Venkatachalam, Manjeri, additional, Ye, Hongping, additional, Zhang, Guanshi, additional, Basit, Mujeeb, additional, Hedayati, S. Susan, additional, Kermani, Asra, additional, Lee, Simon C., additional, Lu, Christopher Y., additional, Miller, R. Tyler, additional, Moe, Orson W., additional, Patel, Jiten, additional, Pillai, Anil, additional, Sambandam, Kamalanathan, additional, Torrealba, Jose, additional, Toto, Robert D., additional, Vazquez, Miguel, additional, Wang, Nancy, additional, Wen, Natasha, additional, Zhang, Dianbo, additional, Park, Harold, additional, Caprioli, Richard M., additional, Patterson, Nathan, additional, Sharman, Kavya, additional, Spraggins, Jeffrey M., additional, Van de Plas, Raf, additional, Basta, Jeanine, additional, Diettman, Sabine M., additional, Gaut, Joseph P., additional, Jain, Sanjay, additional, Rauchman, Michael I., additional, Vijayan, Anitha, additional, Cantley, Lloyd G., additional, Kakade, Vijaykumar R., additional, Moledina, Dennis, additional, Shaw, Melissa M., additional, Ugwuowo, Ugochukwu, additional, Wilson, Francis P., additional, and Arora, Tanima, additional

Published
2021
Full Text
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47. A standard system phantom for magnetic resonance imaging

Author

Stupic, Karl F., primary, Ainslie, Maureen, additional, Boss, Michael A., additional, Charles, Cecil, additional, Dienstfrey, Andrew M., additional, Evelhoch, Jeffrey L., additional, Finn, Paul, additional, Gimbutas, Zydrunas, additional, Gunter, Jeffrey L., additional, Hill, Derek L. G., additional, Jack, Clifford R., additional, Jackson, Edward F., additional, Karaulanov, Todor, additional, Keenan, Kathryn E., additional, Liu, Guoying, additional, Martin, Michele N., additional, Prasad, Pottumarthi V., additional, Rentz, Nikki S., additional, Yuan, Chun, additional, and Russek, Stephen E., additional

Published
2021
Full Text
View/download PDF

48. Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI

Author

Dekkers, Ilona A, de Boer, Anneloes, Sharma, Kaniska, Cox, Eleanor F, Lamb, Hildo J, Buckley, David L, Bane, Octavia, Morris, David M, Prasad, Pottumarthi V, Semple, Scott I K, Gillis, Keith A, Hockings, Paul, Buchanan, Charlotte, Wolf, Marcos, Laustsen, Christoffer, Leiner, Tim, Haddock, Bryan, Hoogduin, Johannes M, Pullens, Pim, Sourbron, Steven, Francis, Susan, Dekkers, Ilona A, de Boer, Anneloes, Sharma, Kaniska, Cox, Eleanor F, Lamb, Hildo J, Buckley, David L, Bane, Octavia, Morris, David M, Prasad, Pottumarthi V, Semple, Scott I K, Gillis, Keith A, Hockings, Paul, Buchanan, Charlotte, Wolf, Marcos, Laustsen, Christoffer, Leiner, Tim, Haddock, Bryan, Hoogduin, Johannes M, Pullens, Pim, Sourbron, Steven, and Francis, Susan

Published
2020

49. Correction to: Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Author

Highfield Research Group, Regenerative Medicine and Stem Cells, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, Sigmund, Eric E, Highfield Research Group, Regenerative Medicine and Stem Cells, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, and Sigmund, Eric E

Published
2020

50. Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI

Author

Researchgr. Cardiovasculaire Radiologie, Circulatory Health, Dekkers, Ilona A, de Boer, Anneloes, Sharma, Kaniska, Cox, Eleanor F, Lamb, Hildo J, Buckley, David L, Bane, Octavia, Morris, David M, Prasad, Pottumarthi V, Semple, Scott I K, Gillis, Keith A, Hockings, Paul, Buchanan, Charlotte, Wolf, Marcos, Laustsen, Christoffer, Leiner, Tim, Haddock, Bryan, Hoogduin, Johannes M, Pullens, Pim, Sourbron, Steven, Francis, Susan, Researchgr. Cardiovasculaire Radiologie, Circulatory Health, Dekkers, Ilona A, de Boer, Anneloes, Sharma, Kaniska, Cox, Eleanor F, Lamb, Hildo J, Buckley, David L, Bane, Octavia, Morris, David M, Prasad, Pottumarthi V, Semple, Scott I K, Gillis, Keith A, Hockings, Paul, Buchanan, Charlotte, Wolf, Marcos, Laustsen, Christoffer, Leiner, Tim, Haddock, Bryan, Hoogduin, Johannes M, Pullens, Pim, Sourbron, Steven, and Francis, Susan

Published
2020

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