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41 results on '"Pras, Elisabeth"'

1. Supplementary Data from Expression of Epidermal Growth Factor Receptor (EGFR) and Activated EGFR Predict Poor Response to (Chemo)radiation and Survival in Cervical Cancer

Author

Noordhuis, Maartje G., primary, Eijsink, Jasper J.H., primary, ten Hoor, Klaske A., primary, Roossink, Frank, primary, Hollema, Harry, primary, Arts, Henriëtte J.G., primary, Pras, Elisabeth, primary, Maduro, John H., primary, Reyners, Anna K.L., primary, de Bock, Geertruida H., primary, Wisman, G. Bea A., primary, Schuuring, Ed, primary, and van der Zee, Ate G.J., primary

Published
2023
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14. The role of ATM and 53BP1 as predictive markers in cervical cancer

Author

Roossink, Frank, Wieringa, Hylke W., Noordhuis, Maartje G., ten Hoor, Klaske A., Kok, Mirjam, Slagter-Menkema, Lorian, Hollema, Harry, de Bock, Geertruida H., Pras, Elisabeth, de Vries, Elisabeth G.E., de Jong, Steven, van der Zee, Ate G.J., Schuuring, Ed, Wisman, G. Bea A., and van Vugt, Marcel A.T.M.

Published
2012
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17. The value of follow-up in patients treated for carcinoma of the vulva

Author

Oonk, Maaike H. M., Hullu, Joanne A. De, Hollema, Harry, Mourits, Marian J. E., Pras, Elisabeth, Wymenga, Anke N. M., and Zee, Ate G. J. Van Der

Subjects
Vulva -- Research, Vulvar cancer -- Care and treatment, Vulvar cancer -- Research, Genital cancer -- Care and treatment, Genital cancer -- Research, Health
Published
2003

21. Outcome of Nonsurgical Management of Extra-Abdominal, Trunk, and Abdominal Wall Desmoid-Type Fibromatosis: A Population-Based Study in the Netherlands

Author

van Broekhoven, Danique L. M., primary, Verschoor, Arie J., additional, van Dalen, Thijs, additional, Grünhagen, Dirk J., additional, den Bakker, Michael A., additional, Gelderblom, Hans, additional, Bovee, Judith V. M. G., additional, Haas, Rick L. M., additional, Bonenkamp, Han J., additional, van Coevorden, Frits, additional, ten Oever, Diederik, additional, van der Graaf, Winette T. A., additional, Flucke, Uta E., additional, Pras, Elisabeth, additional, Reyners, Anna K. L., additional, Westermann, Anneke M., additional, Oldenburger, Foppe, additional, Verhoef, Cornelis, additional, and Steeghs, Neeltje, additional

Published
2018
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23. Hyperthermic isolated limb perfusion, preoperative radiotherapy, and surgery (PRS) a new limb saving treatment strategy for locally advanced sarcomas

Author

Stevenson, Marc G., primary, Seinen, Jojanneke M., additional, Pras, Elisabeth, additional, Brouwers, Adrienne H., additional, van Ginkel, Robbert J., additional, van Leeuwen, Barbara L., additional, Suurmeijer, Albert J. H., additional, Been, Lukas B., additional, and Hoekstra, Harald J., additional

Published
2018
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24. Radical Surgery in Patients With Residual Disease After (Chemo)Radiation for Cervical Cancer

Author

Boers, Aniek, primary, Arts, Henriette J.G., additional, Klip, Harry, additional, Nijhuis, Esther R., additional, Pras, Elisabeth, additional, Hollema, Harry, additional, Wisman, G. Bea A., additional, Nijman, Hans W., additional, Mourits, Marian J.E., additional, Reyners, Anna K.L., additional, de Bock, Geertruida H., additional, Thomas, Gillian, additional, and van der Zee, Ate G.J., additional

Published
2014
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25. Het omentum majus voor de behandeling van weefselschade ontstaan na radiotherapie

Author

Been, Lukas, Wiggers, Theo, and Pras, Elisabeth

Abstract

Four patients presented with tissue damage after having surgery and radiotherapy for a malignancy. Two patients presented with ischaemic tissue damage many years after treatment--a woman aged 71 presented 40 years after and a man aged 56 presented 12 years after treatment. A 44-year-old-woman presented with chronic seroma after surgical resection, which had been aggravated by radiotherapy. In a man aged 48, a chronic infection in irradiated tissue did not respond to antibiotics. These complications proved to be resistant to conservative treatment and surgery was indicated. All patients underwent resection of the damaged irradiated tissues and transposition of the greater omentum, which proved to be effective. The pedicled omentoplasty is able to transpose well-vascularized tissue with angiogenetic and immunological properties to tissues with no spontaneous healing capacity.

Published
2006

27. Feasibility and efficacy of external beam radiotherapy after hyperthermic isolated limb perfusion with TNF-alpha and melphalan for limb-saving treatment in locally advanced extremity soft-tissue sarcoma

Author

Olieman, Annette F T, Pras, Elisabeth, van Ginkel, Robert, Molenaar, Willemina M, Koops, Heimen Schraffordt, Hoekstra, Harald J, and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Subjects
sarcoma, ISOLATED REGIONAL PERFUSION, INTERFERON-GAMMA, SURGERY, tumor necrosis factor, MELANOMA, ACTIVATION, CISPLATIN, RADIATION, TRIAL, COMBINATION, limb perfusion, radiotherapy, TUMOR-NECROSIS-FACTOR
Abstract

Purpose: Hyperthermic isolated limb perfusion (HILP) with tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and melphalan is associated with a dramatic antitumor effect in locally advanced extremity soft-tissue sarcomas (STS). The aim of this study was to demonstrate the feasibility and efficacy of adjuvant radiotherapy after HILP with TNF-alpha, IFN-gamma, and melphalan and delayed surgical resection. Methods and Materials: Between 1991 and 1995, 34 patients-16 males and 18 females, median age 50 (range 18-80) years-underwent HILP for locally advanced extremity STS. Resection of the residual tumor mass was performed in most patients after 6-8 weeks. Fifteen patients with histopathological viable tumor after resection received adjuvent 60-70 Gy external beam radiotherapy (EBRT) (44%, HILP + EBRT group). Nineteen patients received HILP without adjuvent EBRT (56%, HILP-only group). Five patients in the HILP-only group had also distant metastases (15%) and received HILP as a palliative treatment. Treatment morbidity, local recurrences, and regional and distant metastases ere scored. Results: During a median follow-up of 34 months (range 8-54), Limb salvage was achieved in 29 patients (85%): 14 patients after HILP + EBRT and 15 patients after HILP only. None of the patients from the HILP + EBRT group developed local recurrences; however, five patients from the HILP-only did (26%) (p

Published
1998

28. Less Gastrointestinal Toxicity After Adjuvant Radiotherapy on a Small Pelvic Field Compared to a Standard Pelvic Field in Patients With Endometrial Carcinoma

Author

de Jong, Renske A., primary, Pras, Elisabeth, additional, Boezen, H. Marike, additional, van der Zee, Ate G.J., additional, Mourits, Marian J.E., additional, Arts, Henriëtte J.G., additional, Aalders, Jan G., additional, Slot, Annerie, additional, Timmer, Paul R., additional, Hollema, Harry, additional, and Nijman, Hans W., additional

Published
2012
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30. Expression of Epidermal Growth Factor Receptor (EGFR) and Activated EGFR Predict Poor Response to (Chemo)radiation and Survival in Cervical Cancer

Author

Noordhuis, Maartje G., primary, Eijsink, Jasper J.H., additional, ten Hoor, Klaske A., additional, Roossink, Frank, additional, Hollema, Harry, additional, Arts, Henriëtte J.G., additional, Pras, Elisabeth, additional, Maduro, John H., additional, Reyners, Anna K.L., additional, de Bock, Geertruida H., additional, Wisman, G. Bea A., additional, Schuuring, Ed, additional, and van der Zee, Ate G.J., additional

Published
2009
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31. Gynecologic examination and cervical biopsies after (chemo) radiation for cervical cancer to identify patients eligible for salvage surgery

Author

Nijhuis, Esther R., primary, van der Zee, Ate G.J., additional, in ‘t Hout, Bertha A., additional, Boomgaard, Jantine J., additional, de Hullu, Joanne A., additional, Pras, Elisabeth, additional, Hollema, Harry, additional, Aalders, Jan G., additional, Nijman, Hans W., additional, Willemse, Pax H.B., additional, and Mourits, Marian J.E., additional

Published
2006
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36. MLH1 and MSH2 protein expression as a pre-screening marker in hereditary and non-hereditary endometrial hyperplasia and cancer

Author

Berends, Maran J.W., primary, Hollema, Harry, additional, Wu, Ying, additional, van der Sluis, Tineke, additional, Mensink, Rob G.J., additional, ten Hoor, Klaske A., additional, Sijmons, Rolf H., additional, de Vries, Elisabeth G.E., additional, Pras, Elisabeth, additional, Mourits, Marian J.E., additional, Hofstra, Robert M.W., additional, Buys, Charles H.C.M., additional, Kleibeuker, Jan H., additional, and van der Zee, Ate G.J., additional

Published
2001
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39. Isolated Limb Perfusion with Tumor Necrosis Factor Alpha and Melphalan for Locally Advanced Soft Tissue Sarcoma: Three Time Periods at Risk for Amputation.

Author

Ginkel, Robert, Thijssens, Katja, Pras, Elisabeth, Graaf, Winette, Suurmeijer, Albert, and Hoekstra, Harald

Abstract

The aim of this study was to investigate the long-term limb salvage rate and overall survival after isolated limb perfusion (ILP) with tumor necrosis factor alpha and melphalan for locally advanced soft tissue sarcoma (STS). From 1991 to 2003, 73 patients (36 men, 37 women, median age 54 [range 14–80] years) with biopsy-proven STS underwent 77 perfusions followed by delayed surgical resection, with or without adjuvant radiation. Limb salvage and overall survival curves were calculated by the Kaplan-Meier method. A total of 21 amputations (28%) were performed. Overall 1, 5, and 10 years’ limb salvage was 80.1% ± 4.8%, 68.2% ± 6.5%, and 60.6% ± 9.2%, respectively. We found that the risk of amputation was linked to three time periods. The first was within a year after perfusion, mainly as a result of massive necrosis of the tumor and overlying skin, resulting in soft tissue deficit or recurrent disease (n = 17). The second was within 5 years, with two amputations performed for late local recurrence. The third occurred 10 years after perfusion, with two amputations performed for critical leg ischemia. Another two patients developed a pathological fracture of the femur due to radiation osteonecrosis. These four patients received adjuvant radiotherapy. Overall, 1, 5, and 10 years’ survival was 82.9% ± 9.2%, 58.7% ± 13.1%, and 42.5% ± 18.2%, respectively. ILP treatment with tumor necrosis factor alpha and melphalan followed by delayed surgical resection and adjuvant radiation treatment is an effective limb salvage treatment regimen for locally advanced STS. However, we observed late morbidity, with two amputations performed for critical leg ischemia and two pathological fractures of the femur in patients receiving adjuvant radiotherapy. [ABSTRACT FROM AUTHOR]

Published
2007
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41. Clinicopathologic assessment of postradiation sarcomas: KIT as a potential treatment target.

Author

Komdeur R, Hoekstra HJ, Molenaar WM, Van Den Berg E, Zwart N, Pras E, Plaza-Menacho I, Hofstra RM, and Van Der Graaf WT

Subjects
Adolescent, Adult, Aged, Dose-Response Relationship, Radiation, Exons, Female, Hemangiosarcoma enzymology, Humans, Immunohistochemistry, Infant, Male, Middle Aged, Mutation, Prognosis, Radiotherapy adverse effects, Sarcoma enzymology, Soft Tissue Neoplasms enzymology, Time Factors, Neoplasms, Radiation-Induced diagnosis, Proto-Oncogene Proteins c-kit metabolism, Sarcoma diagnosis, Soft Tissue Neoplasms diagnosis
Abstract

Purpose: Postradiation sarcoma, a sarcoma developing in a previously irradiated field, is a rare tumor. Surgery appears to be the only curative treatment option. In general the prognosis is poor, and new treatments options are needed. One study reported the expression of KIT receptor tyrosine kinase in two postradiation angiosarcomas. Success of inhibition of KIT in malignant gastrointestinal stromal tumors with imatinib mesylate seems mutation-dependent, with a favorable response in the presence of exon 11 mutations., Experimental Design: We performed a clinical, immunohistochemical, and genetic assessment of postradiation sarcomas, including angiosarcomas. Archival tumor tissue was available from 16 patients diagnosed with a postradiation sarcoma between 1978 and 2001. Data on the first and secondary tumor, treatment, and follow-up was documented. KIT expression was assessed by immunohistochemistry. For comparison, 23 spontaneous soft tissue sarcomas of similar histological types were analyzed. Exon 11 of the c-kit gene was analyzed by direct DNA sequencing., Results: Fifteen patients received initial irradiation for malignant disease and 1 patient for a benign condition. The median delivered dose was 50 Gy. The median latency period between irradiation and diagnosis of postradiation sarcomas was 222 months. Histological types included: angiosarcoma, fibrosarcoma, malignant fibrous histiocytoma, osteosarcoma, rhabdomyosarcoma, and unspecified sarcoma. In concordance with the literature, patients had a poor outcome. Only 3 of 16 patients were disease-free 43, 60, and 161 months after being diagnosed of postradiation sarcoma, all 3 having favorable tumor and treatment characteristics. Fourteen of 16 tumor samples were KIT-positive (88%). In 8 cases >80% of tumor cells stained positively. Five of 23 (22%) spontaneous soft tissue sarcomas of comparable histological types, including 2 angiosarcomas, were KIT-positive. Molecular genetic analysis of exon 11 of the c-kit gene was attainable for 13 of the 16 postradiation sarcomas. No mutations were found., Conclusions: Postradiation sarcomas are aggressive malignancies, seldom amenable to curative treatment. A majority of the analyzed tumors showed extensive expression of the KIT protein, but no mutations in exon 11 of the c-kit gene were found. Still, without the availability of effective therapies, treatment with the KIT inhibitor imatinib mesylate might be considered for patients with postradiation sarcomas.

Published
2003

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