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29 results on '"Prakken, Niek H.J."'

5. Prevalence of wild‐type transthyretin amyloidosis in a prospective heart failure cohort with preserved and mildly reduced ejection fraction: Results of the Amylo‐VIP‐HF study

Author

Tubben, Alwin, primary, Tingen, Hendrea S.A., additional, Prakken, Niek H.J., additional, van Empel, Vanessa P.M., additional, Gorter, Thomas M., additional, Meems, Laura M.G., additional, Manintveld, Olivier C., additional, Rienstra, Michiel, additional, Tieleman, Robert G., additional, Glaudemans, Andor W.J.M., additional, van Veldhuisen, Dirk J., additional, Slart, Riemer H.J.A., additional, Nienhuis, Hans L.A., additional, and van der Meer, Peter, additional

Published
2024
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7. Mitral Annular Disjunction in Idiopathic Ventricular Fibrillation Patients: Just a Bystander or a Potential Cause?

Author

Verheul, L.M., Guglielmo, M, Groeneveld, Sanne A, Kirkels, F P, Scrocco, C, Cramer, M J, Bootsma, M, Kapel, G. F.L., Alings, Marco A.M.W., Evertz, Reinder, Mulder, Bart A, Prakken, Niek H.J., Balt, Jippe C., Hirsch, Alexander, Yap, Sing-Chien, Volders, Paul G A, Verheul, L.M., Guglielmo, M, Groeneveld, Sanne A, Kirkels, F P, Scrocco, C, Cramer, M J, Bootsma, M, Kapel, G. F.L., Alings, Marco A.M.W., Evertz, Reinder, Mulder, Bart A, Prakken, Niek H.J., Balt, Jippe C., Hirsch, Alexander, Yap, Sing-Chien, and Volders, Paul G A

Abstract

Aims: Previously, we demonstrated that inferolateral mitral annular disjunction (MAD) is more prevalent in patients with idiopathic ventricular fibrillation (IVF) than in healthy controls. In the present study, we advanced the insights into the prevalence and ventricular arrhythmogenicity by inferolateral MAD in an even larger IVF cohort. Methods and results: This retrospective multicentre study included 185 IVF patients (median age 39 [27, 52] years, 40% female). Cardiac magnetic resonance images were analysed for mitral valve and annular abnormalities and late gadolinium enhancement. Clinical characteristics were compared between patients with and without MAD. MAD in any of the 4 locations was present in 112 (61%) IVF patients and inferolateral MAD was identified in 24 (13%) IVF patients. Mitral valve prolapse (MVP) was found in 13 (7%) IVF patients. MVP was more prevalent in patients with inferolateral MAD compared with patients without inferolateral MAD(42% vs. 2%, p < 0.001). Proarrhythmic characteristics in terms of a high burden of premature ventricular complexes (PVC) and non-sustained ventricular tachycardia (VT) were more prevalent in patients with inferolateral MAD compared to patients without inferolateral MAD (67% vs. 23%, p < 0.001 and 63% vs 41%, p = 0.046, respectively). Appropriate implantable cardioverter defibrillator therapy during follow-up was comparable for IVF patients with or without inferolateral MAD (13% vs. 18%, p = 0.579). Conclusion: A high prevalence of inferolateral MAD and MVP is a consistent finding in this large IVF cohort. The presence of inferolateral MAD is associated with a higher PVC burden and non-sustained VTs. Further research is needed to explain this potential interplay.

Published
2024

11. Therapeutic drug monitoring-guided treatment versus standard dosing of voriconazole for invasive aspergillosis in haematological patients: a multicentre, prospective, cluster randomised, crossover clinical trial

Author

Veringa, Anette, primary, Brüggemann, Roger J., additional, Span, Lambert F.R., additional, Biemond, Bart J., additional, de Boer, Mark G.J., additional, van den Heuvel, Edwin R., additional, Klein, Saskia K., additional, Kraemer, Doris, additional, Minnema, Monique C., additional, Prakken, Niek H.J., additional, Rijnders, Bart J.A., additional, Swen, Jesse J., additional, Verweij, Paul E., additional, Wondergem, Mariëlle J., additional, Ypma, Paula F., additional, Blijlevens, Nicole, additional, Kosterink, Jos G.W., additional, van der Werf, Tjip S., additional, and Alffenaar, Jan-Willem C., additional

Published
2023
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12. Therapeutic drug monitoring-guided treatment versus standard dosing of voriconazole for invasive aspergillosis in haematological patients:a multicentre, prospective, cluster randomised, crossover clinical trial

Author

Veringa, Anette, Brüggemann, Roger J., Span, Lambert F.R., Biemond, Bart J., de Boer, Mark G.J., van den Heuvel, Edwin R., Klein, Saskia K., Kraemer, Doris, Minnema, Monique C., Prakken, Niek H.J., Rijnders, Bart J.A., Swen, Jesse J., Verweij, Paul E., Wondergem, Mariëlle J., Ypma, Paula F., Blijlevens, Nicole, Kosterink, Jos G.W., van der Werf, Tjip S., Alffenaar, Jan Willem C., Veringa, Anette, Brüggemann, Roger J., Span, Lambert F.R., Biemond, Bart J., de Boer, Mark G.J., van den Heuvel, Edwin R., Klein, Saskia K., Kraemer, Doris, Minnema, Monique C., Prakken, Niek H.J., Rijnders, Bart J.A., Swen, Jesse J., Verweij, Paul E., Wondergem, Mariëlle J., Ypma, Paula F., Blijlevens, Nicole, Kosterink, Jos G.W., van der Werf, Tjip S., and Alffenaar, Jan Willem C.

Abstract

Objectives: Voriconazole therapeutic drug monitoring (TDM) is recommended based on retrospective data and limited prospective studies. This study aimed to investigate whether TDM-guided voriconazole treatment is superior to standard treatment for invasive aspergillosis. Methods: A multicentre (n = 10), prospective, cluster randomised, crossover clinical trial was performed in haematological patients aged ≥18 years treated with voriconazole. All patients received standard voriconazole dose at the start of treatment. Blood/serum/plasma was periodically collected after treatment initiation of voriconazole and repeated during treatment in both groups. The TDM group had measured voriconazole concentrations reported back, with dose adjustments made as appropriate, while the non-TDM group had voriconazole concentrations measured only after study completion. The composite primary endpoint included response to treatment and voriconazole treatment discontinuation due to an adverse drug reaction related to voriconazole within 28 days after treatment initiation. Results: In total, 189 patients were enrolled in the study. For the composite primary endpoint, 74 patients were included in the non-TDM group and 68 patients in the TDM group. Here, no significant difference was found between both groups (P = 0.678). However, more trough concentrations were found within the generally accepted range of 1–6 mg/L for the TDM group (74.0%) compared with the non-TDM group (64.0%) (P < 0.001). Conclusions: In this trial, TDM-guided dosing of voriconazole did not show improved treatment outcome compared with standard dosing. We believe that these findings should open up the discussion for an approach to voriconazole TDM that includes drug exposure, pathogen susceptibility and host defence. Clinical trial registration: ClinicalTrials.gov registration no. NCT00893555.

Published
2023

13. Therapeutic drug monitoring-guided treatment versus standard dosing of voriconazole for invasive aspergillosis in haematological patients: a multicentre, prospective, cluster randomised, crossover clinical trial

Author

Voriconazole ZonMw Study Group, Veringa, Anette, Brüggemann, Roger J., Span, Lambert F.R., Biemond, Bart J., de Boer, Mark G.J., van den Heuvel, Edwin R., Klein, Saskia K., Kraemer, Doris, Minnema, Monique C., Prakken, Niek H.J., Rijnders, Bart J.A., Swen, Jesse J., Verweij, Paul E., Wondergem, Mariëlle J., Ypma, Paula F., Blijlevens, Nicole, Kosterink, Jos G.W., van der Werf, Tjip S., Alffenaar, Jan Willem C., Voriconazole ZonMw Study Group, Veringa, Anette, Brüggemann, Roger J., Span, Lambert F.R., Biemond, Bart J., de Boer, Mark G.J., van den Heuvel, Edwin R., Klein, Saskia K., Kraemer, Doris, Minnema, Monique C., Prakken, Niek H.J., Rijnders, Bart J.A., Swen, Jesse J., Verweij, Paul E., Wondergem, Mariëlle J., Ypma, Paula F., Blijlevens, Nicole, Kosterink, Jos G.W., van der Werf, Tjip S., and Alffenaar, Jan Willem C.

Abstract

Objectives: Voriconazole therapeutic drug monitoring (TDM) is recommended based on retrospective data and limited prospective studies. This study aimed to investigate whether TDM-guided voriconazole treatment is superior to standard treatment for invasive aspergillosis. Methods: A multicentre (n = 10), prospective, cluster randomised, crossover clinical trial was performed in haematological patients aged ≥18 years treated with voriconazole. All patients received standard voriconazole dose at the start of treatment. Blood/serum/plasma was periodically collected after treatment initiation of voriconazole and repeated during treatment in both groups. The TDM group had measured voriconazole concentrations reported back, with dose adjustments made as appropriate, while the non-TDM group had voriconazole concentrations measured only after study completion. The composite primary endpoint included response to treatment and voriconazole treatment discontinuation due to an adverse drug reaction related to voriconazole within 28 days after treatment initiation. Results: In total, 189 patients were enrolled in the study. For the composite primary endpoint, 74 patients were included in the non-TDM group and 68 patients in the TDM group. Here, no significant difference was found between both groups (P = 0.678). However, more trough concentrations were found within the generally accepted range of 1–6 mg/L for the TDM group (74.0%) compared with the non-TDM group (64.0%) (P < 0.001). Conclusions: In this trial, TDM-guided dosing of voriconazole did not show improved treatment outcome compared with standard dosing. We believe that these findings should open up the discussion for an approach to voriconazole TDM that includes drug exposure, pathogen susceptibility and host defence. Clinical trial registration: ClinicalTrials.gov registration no. NCT00893555.

Published
2023

14. Interpretation of pre-morbid cardiac 3T MRI findings in overweight and hypertensive young adults

Author

Researchgr. Hart-brein as., Brain, Circulatory Health, Snel, Gert J.H., Slart, Riemer H.J.A., Velthuis, Birgitta K., van den Boomen, Maaike, Nguyen, Christopher T., Sosnovik, David E., van Deursen, Vincent M., Dierckx, Rudi A.J.O., Borra, Ronald J.H., Prakken, Niek H.J., Researchgr. Hart-brein as., Brain, Circulatory Health, Snel, Gert J.H., Slart, Riemer H.J.A., Velthuis, Birgitta K., van den Boomen, Maaike, Nguyen, Christopher T., Sosnovik, David E., van Deursen, Vincent M., Dierckx, Rudi A.J.O., Borra, Ronald J.H., and Prakken, Niek H.J.

Published
2022

15. Cardiac Alterations on 3T MRI in Young Adults With Sedentary Lifestyle-Related Risk Factors

Author

Researchgr. Hart-brein as., Brain, Circulatory Health, Snel, Gert J.H., van den Boomen, Maaike, Hurtado-Ortiz, Katia, Slart, Riemer H.J.A., van Deursen, Vincent M., Nguyen, Christopher T., Sosnovik, David E., Dierckx, Rudi A.J.O., Velthuis, Birgitta K., Borra, Ronald J.H., Prakken, Niek H.J., Researchgr. Hart-brein as., Brain, Circulatory Health, Snel, Gert J.H., van den Boomen, Maaike, Hurtado-Ortiz, Katia, Slart, Riemer H.J.A., van Deursen, Vincent M., Nguyen, Christopher T., Sosnovik, David E., Dierckx, Rudi A.J.O., Velthuis, Birgitta K., Borra, Ronald J.H., and Prakken, Niek H.J.

Published
2022

16. Prevalence of Mitral Annulus Disjunction and Mitral Valve Prolapse in Patients With Idiopathic Ventricular Fibrillation

Author

Circulatory Health, Researchgr. Hart-brein as., Brain, Groeneveld, Sanne A., Kirkels, Feddo P., Cramer, Maarten J., Evertz, Reinder, Haugaa, Kristina H., Postema, Pieter G., Prakken, Niek H.J., Teske, Arco J., Wilde, Arthur A.M., Velthuis, Birgitta K., Nijveldt, Robin, Hassink, Rutger J., Circulatory Health, Researchgr. Hart-brein as., Brain, Groeneveld, Sanne A., Kirkels, Feddo P., Cramer, Maarten J., Evertz, Reinder, Haugaa, Kristina H., Postema, Pieter G., Prakken, Niek H.J., Teske, Arco J., Wilde, Arthur A.M., Velthuis, Birgitta K., Nijveldt, Robin, and Hassink, Rutger J.

Published
2022

17. Role of plakophilin-2 expression on exercise-related progression of arrhythmogenic right ventricular cardiomyopathy: A translational study

Author

Cardiologie, Onderzoek Precision medicine, Researchgr. Hart-brein as., Brain, Circulatory Health, Arts Assistenten Cardiologie, Cerrone, Marina, Marrón-Liñares, Grecia M., Van Opbergen, Chantal J.M., Costa, Sarah, Bourfiss, Mimount, Perez-Hernández, Marta, Schlamp, Florencia, Sanchis-Gomar, Fabian, Malkani, Kabir, Drenkova, Kamelia, Zhang, Mingliang, Lin, Xianming, Heguy, Adriana, Velthuis, Birgitta K., Prakken, Niek H.J., Lagerche, Andre, Calkins, Hugh, James, Cynthia A., Te Riele, Anneline S.J.M., Delmar, Mario, Cardiologie, Onderzoek Precision medicine, Researchgr. Hart-brein as., Brain, Circulatory Health, Arts Assistenten Cardiologie, Cerrone, Marina, Marrón-Liñares, Grecia M., Van Opbergen, Chantal J.M., Costa, Sarah, Bourfiss, Mimount, Perez-Hernández, Marta, Schlamp, Florencia, Sanchis-Gomar, Fabian, Malkani, Kabir, Drenkova, Kamelia, Zhang, Mingliang, Lin, Xianming, Heguy, Adriana, Velthuis, Birgitta K., Prakken, Niek H.J., Lagerche, Andre, Calkins, Hugh, James, Cynthia A., Te Riele, Anneline S.J.M., and Delmar, Mario

Published
2022

20. Balancing Speed and Accuracy in Cardiac Magnetic Resonance Function Post-Processing: Comparing 2 Levels of Automation in 3 Vendors to Manual Assessment

Author

Snel, Gert J.H., primary, Poort, Sharon, additional, Velthuis, Birgitta K., additional, van Deursen, Vincent M., additional, Nguyen, Christopher T., additional, Sosnovik, David, additional, Dierckx, Rudi A.J.O., additional, Slart, Riemer H.J.A., additional, Borra, Ronald J.H., additional, and Prakken, Niek H.J., additional

Published
2021
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21. Balancing speed and accuracy in cardiac magnetic resonance function post-processing: Comparing 2 levels of automation in 3 vendors to manual assessment

Author

Researchgr. Hart-brein as., Brain, Circulatory Health, Snel, Gert J.H., Poort, Sharon, Velthuis, Birgitta K., van Deursen, Vincent M., Nguyen, Christopher T., Sosnovik, David, Dierckx, Rudi A.J.O., Slart, Riemer H.J.A., Borra, Ronald J.H., Prakken, Niek H.J., Researchgr. Hart-brein as., Brain, Circulatory Health, Snel, Gert J.H., Poort, Sharon, Velthuis, Birgitta K., van Deursen, Vincent M., Nguyen, Christopher T., Sosnovik, David, Dierckx, Rudi A.J.O., Slart, Riemer H.J.A., Borra, Ronald J.H., and Prakken, Niek H.J.

Published
2021

22. Exercise and Coronary Atherosclerosis: Observations, Explanations, Relevance, and Clinical Management

Author

Circulatory Health, Researchgr. Hart-brein as., Brain, Aengevaeren, Vincent L., Mosterd, Arend, Sharma, Sanjay, Prakken, Niek H.J., Möhlenkamp, Stefan, Thompson, Paul D., Velthuis, Birgitta K., Eijsvogels, Thijs M.H., Circulatory Health, Researchgr. Hart-brein as., Brain, Aengevaeren, Vincent L., Mosterd, Arend, Sharma, Sanjay, Prakken, Niek H.J., Möhlenkamp, Stefan, Thompson, Paul D., Velthuis, Birgitta K., and Eijsvogels, Thijs M.H.

Published
2020

24. Native T1 reference values for nonischemic cardiomyopathies and populations with increased cardiovascular risk : A systematic review and meta-analysis

Author

van den Boomen, Maaike, Slart, Riemer H.J.A., Hulleman, Enzo V., Dierckx, Rudi A.J.O., Velthuis, Birgitta K., van der Harst, Pim, Sosnovik, David E., Borra, Ronald J.H., Prakken, Niek H.J., van den Boomen, Maaike, Slart, Riemer H.J.A., Hulleman, Enzo V., Dierckx, Rudi A.J.O., Velthuis, Birgitta K., van der Harst, Pim, Sosnovik, David E., Borra, Ronald J.H., and Prakken, Niek H.J.

Published
2018

25. Native T1 reference values for nonischemic cardiomyopathies and populations with increased cardiovascular risk: A systematic review and meta-analysis

Author

Researchgr. Hart-brein as., Brain, Circulatory Health, van den Boomen, Maaike, Slart, Riemer H.J.A., Hulleman, Enzo V., Dierckx, Rudi A.J.O., Velthuis, Birgitta K., van der Harst, Pim, Sosnovik, David E., Borra, Ronald J.H., Prakken, Niek H.J., Researchgr. Hart-brein as., Brain, Circulatory Health, van den Boomen, Maaike, Slart, Riemer H.J.A., Hulleman, Enzo V., Dierckx, Rudi A.J.O., Velthuis, Birgitta K., van der Harst, Pim, Sosnovik, David E., Borra, Ronald J.H., and Prakken, Niek H.J.

Published
2018

26. Native T1reference values for nonischemic cardiomyopathies and populations with increased cardiovascular risk: A systematic review and meta‐analysis

Author

van den Boomen, Maaike, primary, Slart, Riemer H.J.A., additional, Hulleman, Enzo V., additional, Dierckx, Rudi A.J.O., additional, Velthuis, Birgitta K., additional, van der Harst, Pim, additional, Sosnovik, David E., additional, Borra, Ronald J.H., additional, and Prakken, Niek H.J., additional

Published
2017
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28. Intermodel Agreement of Myocardial Blood Flow Estimation From Stress-Rest Myocardial Perfusion Magnetic Resonance Imaging in Patients With Coronary Artery Disease

Author

Handayani, Astri, primary, Triadyaksa, Pandji, additional, Dijkstra, Hildebrand, additional, Pelgrim, Gert Jan, additional, van Ooijen, Peter M.A., additional, Prakken, Niek H.J., additional, Schoepf, U. Joseph, additional, Oudkerk, Matthijs, additional, Vliegenthart, Rozemarijn, additional, and Sijens, Paul E., additional

Published
2015
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