40 results on '"Prakesh Shah"'
Search Results
2. Practice recommendations regarding parental presence in NICUs during pandemics caused by respiratory pathogens like COVID-19
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Marsha Campbell-Yeo, Fabiana Bacchini, Lynsey Alcock, Souvik Mitra, Morgan MacNeil, Amy Mireault, Marc Beltempo, Tanya Bishop, Douglas M. Campbell, Addie Chilcott, Jeannette L. Comeau, Justine Dol, Amy Grant, Jonathon Gubbay, Brianna Hughes, Amos Hundert, Darlene Inglis, Alanna Lakoff, Yasmin Lalani, Thuy Mai Luu, Jenna Morton, Michael Narvey, Karel O’Brien, Paula Robeson, Michelle Science, Prakesh Shah, and Leah Whitehead
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COVID-19 ,neonatal care ,parental presence ,practice recommendations ,participatory research (PR) ,pandemic planning ,Pediatrics ,RJ1-570 - Abstract
AimTo co-create parental presence practice recommendations across Canadian NICUs during pandemics caused by respiratory pathogens such as COVID-19.MethodsRecommendations were developed through evidence, context, Delphi and Values and Preferences methods. For Delphi 1 and 2, participants rated 50 items and 20 items respectively on a scale from 1 (very low importance) to 5 (very high). To determine consensus, evidence and context of benefits and harms were presented and discussed within the Values and Preference framework for the top-ranked items. An agreement of 80% or more was deemed consensus.ResultsAfter two Delphi rounds (n = 59 participants), 13 recommendations with the highest rated importance were identified. Consensus recommendations included 6 strong recommendations (parents as essential caregivers, providing skin-to-skin contact, direct or mothers' own expressed milk feeding, attending medical rounds, mental health and psychosocial services access, and inclusion of parent partners in pandemic response planning) and 7 conditional recommendations (providing hands-on care tasks, providing touch, two parents present at the same time, food and drink access, use of communication devices, and in-person access to medical rounds and mental health and psychosocial services).ConclusionThese recommendations can guide institutions in developing strategies for parental presence during pandemics caused by respiratory pathogens like COVID-19
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- 2024
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3. Feasibility of establishing a Canadian Obstetric Survey System (CanOSS) for severe maternal morbidity: a study protocol
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Maria B Ospina, K S Joseph, Amy Metcalfe, Heather Scott, Deshayne B Fell, Thomas van den Akker, Jon Barrett, Prakesh Shah, Beth Murray-Davis, Rohan D’Souza, Stephen Lapinsky, Sara Thorne, Milena Forte, Jocelynn Cook, Rebecca J Seymour, Susie Dzakpasu, Leslie Skeith, Rizwana Ashraf, Josie Chundamala, Sarah A Hutchinson, Kenneth K Chen, and Isabelle Malhamé
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Medicine - Published
- 2022
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4. Grading of Intraventricular Hemorrhage and Neurodevelopment in Preterm
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Vibhuti Shah, Natasha Musrap, Krishanta Maharaj, Jehier Afifi, Walid El-Naggar, Edmond Kelly, Amit Mukerji, Prakesh Shah, and Michael Vincer
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infant–newborn ,cerebral ultrasound ,neurodevelopmental outcome ,Pediatrics ,RJ1-570 - Abstract
Objective: The aim of this study was to evaluate the neurodevelopmental outcome at 18–24 months in surviving preterm infants with grades I–IV intraventricular hemorrhages (IVHs) compared to those with no IVH. Study Design: We included preterm survivors
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- 2022
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5. Relative effectiveness and safety of pharmacotherapeutic agents for patent ductus arteriosus (PDA) in preterm infants: a protocol for a multicentre comparative effectiveness study (CANRxPDA)
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Souvik Mitra, Nadya Ben Fadel, Prakesh Shah, Xiang Y Ye, Amish Jain, Joseph Y. Ting, Ayman Abou Mehrem, Amuchou Soraisham, Bonny Jasani, Abbas Hyderi, Kumar Kumaran, Dany Weisz, Mohammed Adie, Soume Bhattacharya, Rody Canning, Tara Hatfield, and Courtney E Gardner
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Medicine - Abstract
Introduction Patent ductus arteriosus (PDA) is the most common cardiovascular problem that develops in preterm infants and evidence regarding the best treatment approach is lacking. Currently available medical options to treat a PDA include indomethacin, ibuprofen or acetaminophen. Wide variation exists in PDA treatment practices across Canada. In view of this large practice variation across Canadian neonatal intensive care units (NICUs), we plan to conduct a comparative effectiveness study of the different pharmacotherapeutic agents used to treat the PDA in preterm infants.Methods and analysis A multicentre prospective observational comparative-effectiveness research study of extremely preterm infants born
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- 2021
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6. The clinical effectiveness and cost-effectiveness of heated humidified high-flow nasal cannula compared with usual care for preterm infants: systematic review and economic evaluation
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Nigel Fleeman, James Mahon, Vickie Bates, Rumona Dickson, Yenal Dundar, Kerry Dwan, Laura Ellis, Eleanor Kotas, Marty Richardson, Prakesh Shah, and Ben NJ Shaw
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meta-analysis ,randomised controlled trial ,heated humidified high-flow nasal cannula ,nasal continuous positive airway pressure ,infant ,pre-term ,premature ,Medical technology ,R855-855.5 - Abstract
Background: Respiratory problems are one of the most common causes of morbidity in preterm infants and may be treated with several modalities for respiratory support such as nasal continuous positive airway pressure (NCPAP) or nasal intermittent positive-pressure ventilation. The heated humidified high-flow nasal cannula (HHHFNC) is gaining popularity in clinical practice. Objectives: To address the clinical effectiveness of HHHFNC compared with usual care for preterm infants we systematically reviewed the evidence of HHHFNC with usual care following ventilation (the primary analysis) and with no prior ventilation (the secondary analysis). The primary outcome was treatment failure defined as the need for reintubation (primary analysis) or intubation (secondary analysis). We also aimed to assess the cost-effectiveness of HHHFNC compared with usual care if evidence permitted. Data sources: The following databases were searched: MEDLINE (2000 to 12 January 2015), EMBASE (2000 to 12 January 2015), The Cochrane Library (issue 1, 2015), ISI Web of Science (2000 to 12 January 2015), PubMed (1 March 2014 to 12 January 2015) and seven trial and research registers. Bibliographies of retrieved citations were also examined. Review methods: Two reviewers independently screened all titles and abstracts to identify potentially relevant studies for inclusion in the review. Full-text copies were assessed independently. Data were extracted and assessed for risk of bias. Summary statistics were extracted for each outcome and, when possible, data were pooled. A meta-analysis was only conducted for the primary analysis, using fixed-effects models. An economic evaluation was planned. Results: Clinical evidence was derived from seven randomised controlled trials (RCTs): four RCTs for the primary analysis and three RCTs for the secondary analysis. Meta-analysis found that only for nasal trauma leading to a change of treatment was there a statistically significant difference, favouring HHHFNC over NCPAP [risk ratio (RR) 0.21, 95% confidence interval (CI) 0.10 to 0.42]. For the following outcomes, there were no statistically significant differences between arms: treatment failure (reintubation
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- 2016
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7. Neonatal encephalopathy—controversies and evidence
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Nishita Mehta, Prakesh Shah, and Amar Bhide
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Brain Diseases ,Infant, Newborn ,Humans ,Obstetrics and Gynecology ,General Medicine ,Infant, Newborn, Diseases - Published
- 2022
8. Antimicrobial utilization in very-low-birth-weight infants: association with probiotic use
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Amit Mukerji, Prakesh Shah, and Joseph Y Ting
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Pediatrics, Perinatology and Child Health ,Obstetrics and Gynecology - Published
- 2022
9. Feasibility of establishing a Canadian Obstetric Survey System (CanOSS) for severe maternal morbidity: a study protocol
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Rohan D’Souza, Rebecca J Seymour, Marian Knight, Susie Dzakpasu, K S Joseph, Sara Thorne, Maria B Ospina, Jon Barrett, Jocelynn Cook, Deshayne B Fell, Heather Scott, Amy Metcalfe, Thomas van den Akker, Stephen Lapinsky, Leslie Skeith, Beth Murray-Davis, Prakesh Shah, Milena Forte, Rizwana Ashraf, Josie Chundamala, Sarah A Hutchinson, Kenneth K Chen, Isabelle Malhamé, Athena Institute, Network Institute, and APH - Global Health
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Canada ,maternal medicine ,obstetrics ,Pregnancy Outcome ,audit ,General Medicine ,Severity of Illness Index ,Cross-Sectional Studies ,SDG 17 - Partnerships for the Goals ,Pregnancy ,Feasibility Studies ,Humans ,Female ,Maternal Health Services ,adult intensive & critical care - Abstract
IntroductionSevere maternal morbidity (SMM)—an unexpected pregnancy-associated maternal outcome resulting in severe illness, prolonged hospitalisation or long-term disability—is recognised by many, as the preferred indicator of the quality of maternity care, especially in high-income countries. Obtaining comprehensive details on events and circumstances leading to SMM, obtained through maternity units, could complement data from large epidemiological studies and enable targeted interventions to improve maternal health. The aim of this study is to assess the feasibility of gathering such data from maternity units across Canadian provinces and territories, with the goal of establishing a national obstetric survey system for SMM in Canada.Methods and analysisWe propose a sequential explanatory mixed-methods study. We will first distribute a cross-sectional survey to leads of all maternity units across Canada to gather information on (1) Whether the unit has a system for reviewing SMM and the nature and format of this system, (2) Willingness to share anonymised data on SMM by direct entry using a web-based platform and (3) Respondents’ perception on the definition and leading causes of SMM at a local level. This will be followed by semistructured interviews with respondent groups defined a priori, to identify barriers and facilitators for data sharing. We will perform an integrated analysis to determine feasibility outcomes, a narrative description of barriers and facilitators for data-sharing and resource implications for data acquisition on an annual basis, and variations in top-5 causes of SMM.Ethics and disseminationThe study has been approved by the Mount Sinai and Hamilton Integrated Research Ethics Boards. The study findings will be presented at annual scientific meetings of the Society of Obstetricians and Gynaecologists of Canada, North American Society of Obstetric Medicine, and International Network of Obstetric Survey Systems and published in an open-access peer-reviewed Obstetrics and Gynaecology or General Internal Medicine journal.
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- 2022
10. Multisystemic Inflammatory Syndrome in Neonates: A Systematic Review
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Lana A. Shaiba, Kiran More, Adnan Hadid, Rana Almaghrabi, Munira Al Marri, Mahdi Alnamnakani, and Prakesh Shah
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Pediatrics, Perinatology and Child Health ,Developmental Biology - Abstract
Introduction: Multisystem inflammatory syndrome in neonates (MIS-N) related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has increasingly been reported worldwide amid the spread of the SARS-CoV-2 pandemic. Methods: We searched PubMed, EMBASE, and CINAHL and preprint servers (BioRxiv.org and MedRxiv.org) using a specified strategy integrating Medical Subject Headings terms and keywords until October 20, 2021. Our aim was to systematically review demographic profiles, clinical features, laboratory parameters, complications, treatments, and outcomes of neonates with MIS-N. Studies were selected when fulfilling the inclusion criteria. Articles were included if they fulfilled the World Health Organization (WHO), Centers for Disease Control (CDC) definitions of MIS-C, or our proposed definition. Results: Sixteen reports of MIS-N including 47 neonates meeting MIS-N criteria were identified. Presentation included cardiovascular compromise (77%), respiratory involvement (55%), and fever in (36%). Eighty-three percent of patients received steroids, and 76% received immunoglobulin. Respiratory support was provided to 60% of patients and inotropes to 45% of patients. Five (11%) neonates died. Conclusion: The common presentation of MIS-N included cardiorespiratory compromise with the possibility of high mortality. Neonates with MIS-N related to SARS-CoV-2 may be at higher risk of adverse outcomes.
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- 2022
11. Association between Intermittent Hypoxemia and Severe Bronchopulmonary Dysplasia in Preterm Infants
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Erik A. Jensen, Robin K. Whyte, Barbara Schmidt, Dirk Bassler, Nestor E. Vain, Robin S. Roberts, Prakesh Shah, Leanne Brown, Lisa Wenger, Samantha Frye, Francesca Imbesi, Edmond Kelly, Judy D’Ilario, Madan Roy, Joanne Dix, Beth Adams, Janice Cairnie, Patrice Gillie, Elizabeth V. Asztalos, Marilyn Hyndman, Maralyn Lacy, Denise Hohn, Laura Cooper Kruk, Soraya Abbasi, Toni Mancini, Emidio Sivieri, Kathleen Finnegan, Aida Bairam, Sylvie Bélanger, Marianne Deschenes, Annie Fraser, JoAnn Harrold, Jane Frank, Julie Barden, Michael Vincer, Sharon Stone, Yacov Rabi, Reg Sauve, Danielle Cyr, Heather Christianson, Deborah Anseeuw-Deeks, Dianne Creighton, Alfonso Solimano, Lindsay Colby, Arsalan Butt, Anne Synnes, Meredith Peterson, Aasma Chaudhary, Hallam Hurt, Danielle Foy, Kristina Ziolkowski, Marsha Gerdes, Judy Bernbaum, Abraham Peliowski, Manoj Kumar, Leonora Hendson, Melba Athaide, Jill Tomlinson, Christian F. Poets, Jutta Armbruster, Cecilia Garcia, Vanesa DiGruccio, Fernanda Tamanaha, Noemí Jacobi, Silvia Garcia, Norma Vivas, Cristina Osio, Shanthy Sridhar, Aruna Parekh, Rose McGovern, Shmuel Arnon, Michelle Meyer, Rachel Poller, Nabeel Ali, May Khairy, Isabelle Paquet, Larissa Perepolkin, Patricia Grier, Sadia Wali, Mary Seshia, Diane Moddemann, John Minski, Valerie Cook, Kim Kwiatkowski, Karen A. H. Penner, Debbie Williams, Laurentiu Givelichian, Koravangattu Sankaran, Cindy Thiel, David Bader, Bella Sandler, Aaron Chiu, Dayle Everatt, Naomi Granke, Agneta Golan, Esther Goldstein, Shlomith Dadoun, Riitta Vikevainen, Hanna Kallankari, Tuula Kaukola, Mikko Hallman, Keith Barrington, Julie Lavoie, William Fraser, Deborah J. Davis, George Wells, Lorrie Costantini, Wendy Yacura, Bronwyn Gent, and Harvey Nelson
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Male ,Pulmonary and Respiratory Medicine ,Canada ,medicine.medical_specialty ,Critical Care and Intensive Care Medicine ,Hypoxemia ,Internal medicine ,medicine ,Humans ,Hypoxia ,Bronchopulmonary Dysplasia ,Respiratory Distress Syndrome, Newborn ,medicine.diagnostic_test ,business.industry ,Extremely preterm ,Infant, Newborn ,Editorials ,Hypoxia (medical) ,medicine.disease ,Extremely Preterm Infant ,Pathophysiology ,Pulse oximetry ,Bronchopulmonary dysplasia ,Infant, Extremely Premature ,Cardiology ,Female ,medicine.symptom ,business ,Severe Bronchopulmonary Dysplasia - Abstract
Rationale: Bronchopulmonary dysplasia increases the risk of disability in extremely preterm infants. Although the pathophysiology remains uncertain, prior exposure to intermittent hypoxemia may pla...
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- 2021
12. Association of timing of birth with mortality among preterm infants born in Canada
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Salhab El Helou, Amit Mukerji, Prakesh Shah, Joseph Y Ting, Amanda Skoll, Isabelle Marc, Petros Pechlivanoglou, Bruno Piedboeuf, Sandesh Shivananda, Marc Beltempo, Elodie Portales-Casamar, Xiang Y. Ye, Erik Skarsgard, and Darine El-Chaâr
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education.field_of_study ,medicine.medical_specialty ,Evening ,business.industry ,Obstetrics ,Extremely preterm ,Population ,Obstetrics and Gynecology ,Odds ratio ,Logistic regression ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Pediatrics, Perinatology and Child Health ,Epidemiology ,Gestation ,Medicine ,030212 general & internal medicine ,business ,education ,Lower mortality - Abstract
To assess the association between time of birth and mortality among preterm infants. Population-based study of infants born 22–36 weeks gestation (GA) in Canada from 2010 to 2015 (n = 173 789). Multivariable logistic regression models assessed associations between timing of birth and mortality. Among infants 22–27 weeks GA, evening birth was associated with higher mortality than daytime birth (adjusted odds ratio [AOR] 1.14, 95% CI 1.01–1.29). Among infants 28–32 weeks GA and 33–36 weeks GA, night birth was associated with lower mortality than daytime birth (AOR 0.75, 95% CI 0.59–0.95; AOR 0.78, 95% CI 0.62–0.99, respectively). Sensitivity analysis excluding infants with major congenital anomaly revealed that associations between hour of birth and mortality among infants born 28–32 and 33–36 weeks GA decreased or were not statistically significant. Higher mortality among extremely preterm infants during off-peak hours may suggest variations in available resources based on time of day.
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- 2021
13. Association of SARS-CoV-2 Infection During Pregnancy With Maternal and Perinatal Outcomes
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Elisabeth, McClymont, Arianne Y, Albert, Gillian D, Alton, Isabelle, Boucoiran, Eliana, Castillo, Deshayne B, Fell, Verena, Kuret, Vanessa, Poliquin, Tiffany, Reeve, Heather, Scott, Ann E, Sprague, George, Carson, Krista, Cassell, Joan, Crane, Chelsea, Elwood, Chloe, Joynt, Phil, Murphy, Lynn, Murphy-Kaulbeck, Sarah, Saunders, Prakesh, Shah, John W, Snelgrove, Julie, van Schalkwyk, Mark H, Yudin, Deborah, Money, and Wendy, Whittle
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Adult ,Risk ,Canada ,SARS-CoV-2 ,Infant, Newborn ,Pregnancy Outcome ,COVID-19 ,General Medicine ,Middle Aged ,Hospitalization ,Pregnancy ,Population Surveillance ,Humans ,Premature Birth ,Female ,Pregnancy Complications, Infectious ,Original Investigation - Abstract
IMPORTANCE: There are limited high-quality, population-level data about the effect of SARS-CoV-2 infection on pregnancy using contemporaneous comparator cohorts. OBJECTIVES: To describe maternal and perinatal outcomes associated with SARS-CoV-2 infection in pregnancy and to assess variables associated with severe disease in the pregnant population. DESIGN, SETTING, AND PARTICIPANTS: CANCOVID-Preg is an observational surveillance program for SARS-CoV-2–affected pregnancies in Canada. This analysis presents exploratory, population-level data from 6 Canadian provinces for the period of March 1, 2020, to October 31, 2021. A total of 6012 pregnant persons with a positive SARS-CoV-2 polymerase chain reaction test result at any time in pregnancy (primarily due to symptomatic presentation) were included and compared with 2 contemporaneous groups including age-matched female individuals with SARS-CoV-2 and unaffected pregnant persons from the pandemic time period. EXPOSURE: SARS-CoV-2 infection during pregnancy. Incident infections in pregnancy were reported to CANCOVID-Preg by participating provinces/territories. MAIN OUTCOMES AND MEASURES: Maternal and perinatal outcomes associated with SARS-CoV-2 infection as well as risk factors for severe disease (ie, disease requiring hospitalization, admission to an intensive care unit/critical care unit, and/or oxygen therapy). RESULTS: Among 6012 pregnant individuals with SARS-CoV-2 in Canada (median age, 31 [IQR, 28-35] years), the greatest proportion of cases were diagnosed at 28 to 37 weeks’ gestation (35.7%). Non-White individuals were disproportionately represented. Being pregnant was associated with a significantly increased risk of SARS-CoV-2–related hospitalization compared with SARS-CoV-2 cases among all women aged 20 to 49 years in the general population of Canada (7.75% vs 2.93%; relative risk, 2.65 [95% CI, 2.41-2.88]) as well as an increased risk of intensive care unit/critical care unit admission (2.01% vs 0.37%; relative risk, 5.46 [95% CI, 4.50-6.53]). Increasing age, preexisting hypertension, and greater gestational age at diagnosis were significantly associated with worse maternal outcomes. The risk of preterm birth was significantly elevated among SARS-CoV-2–affected pregnancies (11.05% vs 6.76%; relative risk, 1.63 [95% CI, 1.52-1.76]), even in cases of milder disease not requiring hospitalization, compared with unaffected pregnancies during the same time period. CONCLUSIONS AND RELEVANCE: In this exploratory surveillance study conducted in Canada from March 2020 to October 2021, SARS-CoV-2 infection during pregnancy was significantly associated with increased risk of adverse maternal outcomes and preterm birth.
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- 2022
14. Association of NEDA-4 With No Long-term Disability Progression in Multiple Sclerosis and Comparison With NEDA-3: A Systematic Review and Meta-analysis
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Dalia Rotstein, Jacqueline M. Solomon, Maria Pia Sormani, Xavier Montalban, Xiang Y. Ye, Dina Dababneh, Alexandra Muccilli, Georges Saab, Prakesh Shah, Institut Català de la Salut, [Rotstein D] Department of Medicine, University of Toronto, Ontario, Canada, St. Michael’s Hospital, Toronto, Ontario, Canada. [Solomon JM] Department of Medicine, McMaster University, Hamilton, Ontario, Canada. [Sormani MP] Department of Health Sciences, Section of Biostatistics, University of Genova, Italy, IRCCS Ospedale Policlinico San Martino, Genova, Italy. [Montalban X] Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya, Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Ye XY] Department of Pediatrics, Mount Sinai Hospital, Toronto, Canada. [Dababneh D] Columbia University Irving Medical Center, Department of Neurology, New York City, New York Presbyterian Hospital (NYP), New York City, and Vall d'Hebron Barcelona Hospital Campus
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Multiple Sclerosis ,Fingolimod Hydrochloride ,Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis [DISEASES] ,Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores] ,Interferon-beta ,Other subheadings::Other subheadings::/drug therapy [Other subheadings] ,Esclerosi múltiple - Prognosi ,afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::progresión de la enfermedad [ENFERMEDADES] ,Multiple Sclerosis, Relapsing-Remitting ,Neurology ,enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple [ENFERMEDADES] ,Disease Progression ,Humans ,Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression [DISEASES] ,Neurology (clinical) ,Esclerosi múltiple - Tractament - Abstract
Background and ObjectivesNo evidence of disease activity (NEDA)-4 has been suggested as a treatment target for disease-modifying therapy (DMT) in relapsing-remitting multiple sclerosis (RRMS). However, the ability of NEDA-4 to discriminate long-term outcomes in MS and how its performance compares with NEDA-3 remain uncertain. We conducted a systematic review and meta-analysis to evaluate (1) the association between NEDA-4 and no long-term disability progression in MS and (2) the comparative performance of NEDA-3 and NEDA-4 in predicting no long-term disability progression.MethodsEnglish-language abstracts and manuscripts were systematically searched in MEDLINE, Embase, and the Cochrane databases from January 2006 to November 2021 and reviewed independently by 2 investigators. We selected studies that assessed NEDA-4 at 1 or 2 years after DMT start and had at least 4 years of follow-up for determination of no confirmed disability progression. We conducted a meta-analysis using random-effects model to determine the pooled odds ratio (OR) for no disability progression with NEDA-4 vs EDA-4. For the comparative analysis, we selected studies that evaluated both NEDA-3 and NEDA-4 with at least 4 years of follow-up and examined the difference in the association of NEDA-3 and NEDA-4 with no disability progression.ResultsFive studies of 1,000 patients (3 interferon beta and 2 fingolimod) met inclusion criteria for both objectives. The median duration of follow-up was 6 years (interquartile range: 4–6 years). The prevalence of NEDA-4 ranged from 4.2% to 13.9% on interferon beta therapy and 24.9% to 25.1% on fingolimod therapy. The pooled OR for no long-term confirmed disability progression with NEDA-4 vs EDA-4 was 2.14 (95% confidence interval: 1.36–3.37; I2= 0). We did not observe any significant difference between NEDA-4 and NEDA-3 in the comparative analyses.DiscussionIn patients with RRMS, NEDA-4 at 1–2 years was associated with 2 times higher odds of no long-term disability progression, at 6 years compared with EDA-4, but offered no advantage over NEDA-3.
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- 2022
15. Peripartum Outcomes Following COVID-19 Vaccination in Late Pregnancy: Findings from a Population-Based Retrospective Cohort Study in Ontario, Canada
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Darine El-Chaâr, Tavleen Dhinsa, Gillian Alton, Eszter Torok, Sheryll Dimanlig-Cruz, Annette Regan, Ann Sprague, Sarah Buchan, Jeffrey Kwong, Sarah Wilson, Siri Haberg, Christopher Gravel, Kumanan Wilson, Mark Walker, Jon Barrett, Shannon MacDonald, Nannette Okun, Prakesh Shah, Shelley Dougan, Sandra Dunn, Lise Bisnaire, and Deshayne Fell
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Obstetrics and Gynecology - Published
- 2022
16. Association of No Evidence of Disease Activity With No Long-term Disability Progression in Multiple Sclerosis: A Systematic Review and Meta-analysis
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Dalia Rotstein, Jacqueline Madeleine Solomon, Maria Pia Sormani, Xavier Montalban, Xiang Y. Ye, Dina Dababneh, Alexandra Muccilli, and Prakesh Shah
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Neurology (clinical) - Abstract
Background and ObjectivesWe conducted a systematic review and meta-analysis to evaluate the relationship between no evidence of disease activity (NEDA) and no long-term disability progression on low- and high-efficacy therapy in relapsing-remitting multiple sclerosis (RRMS).MethodsMEDLINE, Embase, and the Cochrane Database were searched from January 1, 2006, to January 26, 2021. We selected studies that evaluated NEDA-3 (no relapse, new MRI lesion, or confirmed disability progression) at 1 or 2 years and had a minimum of 4 years of follow-up for determination of disability progression. Data were extracted by 2 independent reviewers and were meta-analyzed with a random-effects model. Primary outcome of no disability progression was defined as no confirmed progression on the Expanded Disability Status Scale during follow-up. We assessed the odds ratio (OR) for no disability progression with NEDA vs evidence of disease activity (EDA). Positive predictive value (PPV) of NEDA for no disability progression was summarized for studies with prevalence of no progression >80% vs ≤80% separately.ResultsWe included 29 studies in our qualitative synthesis, of which 27 (16 low efficacy, 11 high efficacy) were included in the meta-analysis (N = 10,935 participants). Median follow-up was 5.6 years (interquartile range 4.3–8.0 years). The pooled ORs for no progression with NEDA-3 vs EDA were 2.32 (95% CI 1.58–3.42; I2 = 73%) for low-efficacy therapy and 3.19 (95% CI 1.86–5.47; I2 = 86%) for high-efficacy therapy. Among studies with prevalence of no progression at follow-up >80%, the pooled PPV for low efficacy therapy was 91% (95% CI 89%–93%) and for high-efficacy therapy was 92% (95% CI 88%–94%). Among studies with prevalence of no progression ≤80%, the pooled PPV for low-efficacy therapy was 81% (95% CI 75%–86%) and for high-efficacy therapy was 86% (95% CI 80%–90%).DiscussionNEDA-3 is associated with no long-term disability progression in RRMS on both low- and high-efficacy therapies. Further studies of early composite outcome measures incorporating easily measurable biomarkers and longer follow-up may help to improve the prognostic value of NEDA-3 in RRMS.Trial Registration InformationInternational Prospective Register of Systematic Reviews Identifier: CRD42020189316.
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- 2021
17. Rates and Determinants of Home Nasogastric Tube Feeding in Infants Born Very Preterm
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Belal Alshaikh, Kamran Yusuf, Donna Dressler-Mund, Ayman Abou Mehrem, Sajit Augustine, Jaya Bodani, Eugene Yoon, and Prakesh Shah
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Cohort Studies ,Male ,Canada ,Enteral Nutrition ,Brain Injuries ,Infant, Extremely Premature ,Intensive Care Units, Neonatal ,Pediatrics, Perinatology and Child Health ,Infant, Newborn ,Humans ,Infant ,Gestational Age ,Bronchopulmonary Dysplasia - Abstract
To examine rates and determinants of home nasogastric (NG)-tube feeding at hospital discharge in a cohort of very preterm infants within the Canadian Neonatal Network (CNN).This was a population-based cohort study of infants born33 weeks of gestation and admitted to neonatal intensive care units (NICUs) participating in the CNN between January 1, 2010, and December 31, 2018. We excluded infants who had major congenital anomalies, required gastrostomy-tube, or were discharged to non-CNN facilities. Multivariable logistic regression analysis was used to identify independent determinants of home NG-tube feeding at hospital discharge.Among the 13 232 infants born very preterm during the study period, 333 (2.5%) were discharged home to receive NG-tube feeding. Rates of home NG-tube feeding varied across Canadian NICUs, from 0% to 12%. Determinants of home NG-tube feeding were gestational age (aOR 0.94 per each gestational week increase, 95% CI 0.88-0.99); duration of mechanical ventilation (aOR 1.02 per each day increase, 95% CI 1.01-1.02); high illness severity at birth (aOR 1.32, 95% CI 1.01-1.74); small for gestational age (aOR 2.06, 95% CI 1.52-2.78); male sex (aOR 0.61, 95% CI 0.49-0.77); severe brain injury (aOR 1.60, 95% CI 1.10-2.32); and bronchopulmonary dysplasia (aOR 2.22, 95% CI 1.67-2.94).Rates of home NG-tube feeding varied widely between Canadian NICUs. Higher gestational age and male sex reduced the odds of discharge home to receive NG-tube feeding; and in contrast small for gestational age, severe brain injury, prolonged duration on mechanical ventilation and bronchopulmonary dysplasia increased the odds.
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- 2022
18. Single Dose of Antenatal Corticosteroids (SNACS) Non-Inferiority Randomized Controlled Trial for Pregnancies at Risk of Preterm Delivery
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Sarah McDonald, George Tomlinson, Jodie Dodd, Elizabeth Asztalos, Thierry Lacaze-Masmonteil, Prakesh Shah, Fabiana Bacchini, Isabelle Boucoiran, Barbra de Vrijer, Victoria Allen, Amit Mukerji, Mark Walker, Graeme Smith, Nir Melamed, Salim Yusuf, Louis Schmidt, Stephen Matthews, K.S. Joseph, Petros Pechlivanoglou, and Kellie Murphy
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Obstetrics and Gynecology - Published
- 2022
19. Risk factors for re-hospitalization following neonatal discharge of extremely preterm infants in Canada
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Zakariya Bambala, Puthattayil, Thuy Mai, Luu, Marc, Beltempo, Shannon, Cross, Thevanisha, Pillay, Marilyn, Ballantyne, Anne, Synnes, Prakesh, Shah, Thierry, Daboval, and Charles, Janeway
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NICU ,Pediatrics ,medicine.medical_specialty ,Univariate analysis ,Neonatal intensive care unit ,business.industry ,Extremely preterm ,Infant ,Gestational age ,Logistic regression ,medicine.disease ,Risk factors ,Bronchopulmonary dysplasia ,Neonatal follow-up ,Re-hospitalization ,Pediatrics, Perinatology and Child Health ,Necrotizing enterocolitis ,Health care ,medicine ,Online Only Original Articles ,business ,Cohort study - Abstract
Objective Survivors of extremely preterm birth are at risk of re-hospitalization but risk factors in the Canadian population are unknown. Our objective is to identify neonatal, sociodemographic, and geographic characteristics that predict re-hospitalization in Canadian extremely preterm neonates. Methods This is a retrospective analysis of a prospective observational cohort study that included preterm infants born 22 to 28 weeks’ gestational age from April 1, 2009 to September 30, 2011 and seen at 18 to 24 months corrected gestational age in a Canadian Neonatal Follow-Up Network clinic. Characteristics of infants re-hospitalized versus not re-hospitalized are compared. The potential neonatal, sociodemographic, and geographic factors with significant association in the univariate analysis are included in a multivariate model. Results From a total of 2,275 preterm infants born at 22 to 28 weeks gestation included, 838 (36.8%) were re-hospitalized at least once. There were significant disparities between Canadian provincial regions, ranging from 25.9% to 49.4%. In the multivariate logistic regression analysis, factors associated with an increased risk for re-hospitalization were region of residence, male sex, bronchopulmonary dysplasia, necrotizing enterocolitis, prolonged neonatal intensive care unit (NICU) stay, ethnicity, Indigenous ethnicity, and sibling(s) in the home. Conclusion Various neonatal, sociodemographic, and geographic factors predict re-hospitalization of extremely preterm infants born in Canada. The risk factors of re-hospitalization provide insights to help health care leaders explore potential preventative approaches to improve child health and reduce health care system costs.
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- 2019
20. Canadian Society of Surgical Oncology Annual General MeetingUrinary metabolomics of gastric cancerSentinel lymph node biopsy in thin melanoma: a systematic review and meta-analysisPreoperative neutrophil:lymphocyte ratio is a better prognostic serum biomarker than platelet:lymphocyte ratio in patients undergoing resection for nonmetastatic colorectal cancerPatient decision-making in palliative surgeryHospital readmission after surgery for gastric cancer: frequency, timing, etiologies and survivalClinical features and outcomes of 20 patients with desmoplastic small round cell tumourBiliary drainage procedures for palliation of extrahepatic cholangiocarcinomaLong-term outcomes following level-3 axillary lymph node dissection for breast cancerAdverse events related to lymph node dissection for cutaneous melanoma: a systematic review and meta-analysisCollaborative case conferences in rectal cancer: case series in a tertiary care centre
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Cagla Eskicioglu, Haytham H. Alabbas, Heather M. Poushay, Benjamin T. Turner, Fernando A. Angarita, Shaila J. Merchant, Trevor D. Hamilton, Woo Jin Choi, Erin Cordeiro, Angela W. Chan, David Broadhurst, Pascal Mercier, Daniel Schiller, Dean T. Eurich, Sarah Robbins, Michael B. Sawyer, Mai-Kim Gervais, Prakesh Shah, Nicole Look Hong, Frances C. Wright, Michelle C. Cleghorn, Haiyan Jiang, Timothy D. Jackson, Allan Okrainec, Fayez A. Quereshy, Melanie E. Tsang, Audrey Kim, Debbie Selby, Philip H.G Ituarte, Audrey Choi, Virginia Sun, Joseph Chao, Joseph Kim, Saima Hassan, Amanda J. Cannell, Brendan C. Dickson, Rebecca A. Gladdy, Carol J. Swallow, David Hogg, Abha Gupta, Martin E. Blackstein, J. Andrea McCart, Julia Bowes, Cynthia Fasola, Chad Ball, Elijah Dixon, Francis R. Sutherland, Oliver F. Bathe, Julie Hallet, Nicole Look-Hong, Angel M. Rodriguez-Rivera, Stanimira Krotneva, Sue-Ling Chang, Laura Patakfalvi, Tara Landry, Ari Meguerditchian, Nalin Amin, Margherita Cadeddu, Shawn Forbes, Stephen Kelly, Ilun Yang, Scott Tsai, Valerie Francescutti, Angela Coates, Vanja Grubac, Ranil Sonnandara, and Marko Simunovic
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Surgery - Published
- 2015
21. Risk factors associated with severe IVH in outborn infants <33 weeks
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Stephanie Redpath, Kyong-Soon Lee, Prakesh Shah, Gregory Moore Ontario, and Junmin Yang
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Pediatrics, Perinatology and Child Health - Published
- 2019
22. Neighbourhood Income Level and Outcomes of Extremely Preterm Neonates: Protection Conferred by a Universal Health Care System
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Gary, Ko, Prakesh, Shah, Lajos, Kovacs, Cecil, Ojah, Patricia, Riley, Shoo K, Lee, and Herve, Walti
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Male ,Canada ,Pediatrics ,medicine.medical_specialty ,Neonatal intensive care unit ,Infant, Premature, Diseases ,Cohort Studies ,Residence Characteristics ,Universal Health Insurance ,Intensive Care Units, Neonatal ,Poverty Areas ,Intensive care ,Infant Mortality ,medicine ,Humans ,Socioeconomic status ,Neighbourhood (mathematics) ,Population Density ,business.industry ,Infant, Newborn ,Public Health, Environmental and Occupational Health ,Retinopathy of prematurity ,General Medicine ,Odds ratio ,medicine.disease ,Confidence interval ,Infant, Extremely Premature ,Necrotizing enterocolitis ,Income ,Female ,Morbidity ,Quantitative Research ,business ,Demography - Abstract
OBJECTIVES: To determine the impact of neighbourhood income and maternal residence population density on mortality and various morbidities at discharge or transfer from the NICU among extremely preterm neonates (
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- 2012
23. MP09-10 SURGERY VERSUS RADIOTHERAPY FOR CLINICALLY-LOCALIZED PROSTATE CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS
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Christopher Wallis, Refik Saskin, Richard Choo, Sender Herschorn, Ronald Kodama, Raj Satkunasivam, Prakesh Shah, Cyril Danjoux, and Robert Nam
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Urology - Published
- 2016
24. Neonatal Outcomes of Very Low Birth Weight and Very Preterm Neonates: An International Comparison
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Prakesh S. Shah, Kei Lui, Gunnar Sjörs, Lucia Mirea, Brian Reichman, Mark Adams, Neena Modi, Brian A. Darlow, Satoshi Kusuda, Laura San Feliciano, Junmin Yang, Stellan Håkansson, Rintaro Mori, Dirk Bassler, Josep Figueras-Aloy, Shoo K. Lee, Nadia Badawi, Peter Marshall, Paul Craven, Karen Simmer, Jacqueline Stack, Dan Casalaz, Elizabeth Carse, Lucy Cooke, Vijay Shingde, David Cartwright, Rod Hunt, Charles Kilburn, Peter Dargaville, Mary Paradisis, Ingrid Rieger, Carl Kuschel, Andrew Numa, Hazel Carlisle, Guan Koh, Chad Andersen, Melissa Luig, Nicola Austin, Roland Broadbent, Lindsay Mildenhall, Malcolm Battin, David Bourchier, Vaughan Richardson, Anne Synnes, Nicole Rouvinez-Bouali, Bruno Piedboeuf, Barbara Bulleid, Wendy Yee, Nalini Singhal, Adele Harrison, Cherrie Tan-Dy, Sandesh Shivananda, Kenneth Tan, Andrew James, Molly Seshia, Keith Barrington, Francine Lefebvre, Doug McMillan, Wayne Andrews, Lajos Kovacs, Kimberly Dow, Maxine Clarke, Patricia Riley, Prakesh Shah, Arne Ohlsson, Khalid Aziz, Abraham Peliowski, Zenon Cieslak, Todd Sorokan, Zarin Kalapesi, Abraham Ninan, Koravangattu Sankaran, Daniel Faucher, Gerarda Cronin, Roderick Canning, Orlando da Silva, David Lee, Cecil Ojah, Michael Dunn, Eli Heymann, Shmuel Zangen, Amir Kushnir, Francis Mimouni, David Bader, Avi Rothschild, Zipora Strauss, Clari Felszer, Jamalia Jeryes, Smadar Even Tov-Friedman, Benjamin Bar-Oz, Michael Feldman, Nizar Saad, Orna Flidel-Rimon, Meir Weisbrod, Daniel Lubin, Ita Litmanovitz, Shraga Blazer, Eric Shinwell, Leah Sirota, Yousif Nijim, Agneta Golan, Dror Mandel, Vered Fleisher-Sheffer, David Kohelet, Lev Bakhrakh, Satoshi Hattori, Shohei Konishi, Takasuke Amizuka, Takeo Kasai, Ritsuko Takahasi, Hirokazu Arai, Maki Sato, Yayoi Miyazono, Junichi Shimizu, Hiroshi Suzumura, Yumi Kono, Takahiro Inoue, Hiroshi Miyabayashi, Hisanori Sobajima, Rika Ishiguro, Hiroyuki Sato, Satsuki Totsu, Nozomi Ishii, Shigeharu Hosono, Mika Shiraishi, Humihiro Miura, Atsushi Nakao, Hitoshi Yoda, Mitsumasa Shimizu, Kazuo Seki, Yasuhumi Itani, Keiji Suzuki, Atsushi Nemoto, Tomohiko Nakamura, Masaki Wada, Yoshihisa Nagayama, Osamu Numata, Takeshi Futatani, Yasuhisa Ueno, Kazuyuki Iwai, Yoshinori Kono, Shigeru Ooki, Yusuke Nakazawa, Chizuko Suzuki, Taihei Tanaka, Motoki Bonno, Kenji Nakamura, Minako Kihara, Hiroyuki Sano, Atsushi Shiraishi, Atsushi Ohashi, Hiroyuki Ichiba, Kiyoaki Sumi, Seiji Yoshimoto, Yukihiro Takahashi, Takahiro Okutani, Masumi Miura, Fumihide Kato, Shinichi Watabe, Misao Kageyama, Rie Fukuhara, Michiko Hayashitani, Keiko Hasegawa, Kosuke Koyano, Shoko Kobayashi, Shinosuke Akiyoshi, Yusei Nakata, Takeshi Kanda, Hisano Tadashi, Hiroshi Kanda, Masaki Nakamura, Naoko Matsumoto, Masayuki Ochiai, Mikihiro Aoki, Akihiko Kawase, Koichi Iida, Chie Ishihara, Moriyasu Kohama, Ma José Fernández Seara, José Ma Fraga Bermúdez, Andrés Martínez Gutiérrez, María Mercedes Martínez Ayúcar, Carolina Vizcaíno Díaz, José Luis Quiles Durá, María González Santacruz, Ma Anne Feret Siguile, Adela Rodríguez Fernández, Belén Fernández Colomer, Enrique García López, Josep Figuera Aloy, Francesc Botet Mussons, Israel Anquela Sanz, Gemma Ginovart Galiana, Elisenda Moliner Calderon, Antonio Natal Pujol, Alicia Mirada Vives, Martín Iriondo Sanz, Roser Porta, Eva Capdevila Cogul, Laura Castells Vilella, Bruno Alonso Álvarez, José María Montero Macarro, Ana R. Barrio Sacristán, Ma Jesús López Cuesta, Ortiz Tardío, Eugenia Valls Sánchez Puerta, Isabel Benavente Fernández, Juan Mena Romero, María Dolores Martinez Gimenez, Ramón Aguilera Olmos, Ricardo Tosca Segura, Juana Ma Guzmán Cabañas, Ma Dolores Huertas Muñoz, Alberto Trujillo, Luis Fidel Moltó Ripoll, José Antonio Hurtado Suazo, Ana Elena Aldea Romero, Luis Paisán Grisolía, Ana Isabel Garrido Ocana, Eduardo Garcia Soblechero, Ma Yolanda Ruiz del Prado, Inés Esteba Díez, Gema E. González-Luis, Fermín García-Muñoz Rodrigo, Emilio Álvaro Iglesias, Fernando Fernandez Calvo, Eduard Solé Mir, Jordi Garcia Martí, Roberto Ortiz Movilla, Lucía Cabanillas Vilaplana, Marta García San Miguel, Isabel Llana Martín, María Fernández Díaz, Jesús Pérez Rodríguez, Sofía Salas, Carmen Muñoz Labian, Carmen González Armengod, Laura Domingo Comeche, Tomás Sánchez Tamayo, Manuel García del Río, José Ángel Alonso Gallego, José María Lloreda Garcia, Javier Vilas González, null Ocampo, Nieves Balado Insunza, Pilar García González, Mercedes Granero Asencio, Antonia López Sanz, Carmen Macías Díaz, Araceli Ferrari Cortés, Pedro Amadeo Fuster Jorge, Santiago López Mendoza, Sabina Romero Ramírez, Ma del Mar Albújar Font, Alicia de Ureta Huertas, Antonio Arroyos Plana, Javier Estañ Capell, Vicente Roqués, F. Morcillo, Sara Marín, María Fernanda Omaña, Gabriel Saitua Iturriaga, Jiri Kofron, Katarina Strand Brodd, Andreas Odlind, Lars Alberg, Sofia Arwehed, Eva Engström, Anna Kasemo, Charlotte Ekelund, Lars Åhman, Fredrik Ingemarsson, Laura Österdahl, Pernilla Thurn, Eva Albinsson, Bo Selander, Fredrik Lundberg, Ingela Heimdahl, Ola Hafström, Erik Wejryd, Johanna Kuusima-Löfbom, Ellen-Elisabeth Lund, Annelie Thorén, Boubou Hallberg, Eva Berggren Broström, Torbjörn Hertzberg, Björn Stjernstedt, Johan Robinson, Aijaz Farooqi, Erik Normann, Magnus Fredriksson, Anders Palm, Åsa Hedblom, Kenneth Sjöberg, Leif Thorbjörnsson, Andreas Ohlin, Rein Florell, Agneta Smedsaas-Löfvenberg, Philipp Meyer, Claudia Anderegg, Sven Schulzke, Mathias Nelle, Bendicht Wagner, Walter Bär, Grégoire Kaczala, Riccardo E. Pfister, Jean-François Tolsa, Matthias Roth, Thomas M. Berger, Bernhard Laubscher, Andreas Malzacher, John P. Micallef, Lukas Hegi, Romaine Arlettaz, Vera Bernet, Santanu Bag, Jonathan Kefas, Oliver Rackham, Arumugavelu Thirumurgan, Bill Yoxall, Tim McBride, Delyth Webb, Laweh Amegavie, Ahmed Hassan, Priyadarshan Ambadkar, Mark Dyke, Seif Babiker, Susan Rubin, Amanda Ogilvy-Stuart, Nagesh Panasa, Paul Settle, Jonathan Moise, Ngozi Edi-Osagie, Carrie Heal, Jacqeline Birch, Abdul Hasib, Aung Soe, Niraj Kumar, Hamudi Kisat, Vimal Vasu, Meera Lama, Richa Gupta, Chris Rawlingson, Tim Wickham, Karin Schwarz, Van Sommen, Sara Watkin, Aashish Gupta, Narendra Aladangady, Imdad Ali, Lesley Alsford, Khalid Mannan, Ebel Rainer, Nicholas Wilson, Mark Thomas, Ramnik Mathur, Michele Cruwys, Sunit Godambe, Timothy Watts, Jauro Kuna, John Chang, Jon Filkin, Charlotte Huddy, Ruth Shephard, Krzystof Zieba, Patti Rao, Andrew Currie, Azhar Manzoor, Munir Ahmed, Phil Simmons, Julie Nycyk, Andrew Gallagher, Chrisantha Halahakoon, Sanjeev Deshpande, Anand Mohite, Kate Palmer, Alan Gibson, Mehdi Garbash, Mithilesh Lal, Majd Abu-Harb, Róisín McKeon-Carter, Michael Selter, Paul Munyard, Vaughan Lewis, Mala Raman, Graham Whincup, Abdus Mallik, Philip Amess, Charles Godden, Peter Reynolds, Indranil Misra, Naveen Shettihalli, Peter De Halpert, Sanjay Salgia, Rekha Sanghavi, Ruth Wigfield, Abby Deketelaere, Minesh Khashu, Michael Hall, Charlotte Groves, Nick Brown, Nick Brennan, Katia Vamvakiti, Mal Ratnayaka, Simon Pirie, Stephen Jones, Paul Mannix, David Harding, Megan Eaton, David Gibson, and Lawrence Miall
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Male ,Pediatrics ,medicine.medical_specialty ,Population ,Infant, Premature, Diseases ,Logistic regression ,Global Health ,Odds ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,medicine ,Humans ,Infant, Very Low Birth Weight ,030212 general & internal medicine ,education ,Retrospective Studies ,education.field_of_study ,business.industry ,Mortality rate ,Infant, Newborn ,Retrospective cohort study ,Retinopathy of prematurity ,medicine.disease ,Low birth weight ,Bronchopulmonary dysplasia ,Infant, Extremely Premature ,Pediatrics, Perinatology and Child Health ,Female ,medicine.symptom ,business ,Demography - Abstract
OBJECTIVE To compare rates of a composite outcome of mortality or major morbidity in very-preterm/very low birth weight infants between 8 members of the International Network for Evaluating Outcomes. STUDY DESIGN We included 58 004 infants born weighing
- Published
- 2016
25. Additional file 1: of Disparities in a provision of in-hospital post-arrest interventions for out-of-hospital cardiac arrest (OHCA) in the elderly populationâ protocol for a systematic review
- Author
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Bielecki, Joanna, Wong, Josephine, Mitsakakis, Nicholas, Prakesh Shah, Krahn, Murray, and Rac, Valeria
- Abstract
The PRISMA-P checklist has been utilized and uploaded as required by the Systematic Reviews author guidelines. (DOC 80Â kb)
- Published
- 2016
- Full Text
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26. High Gestational Weight Gain and the Risk of Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis
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Sarah D. McDonald, Zhen Han, Sohail Mulla, Olha Lutsiv, Tiffany Lee, Joseph Beyene, null Knowledge Synthesis Group, Prakesh Shah, Arne Ohlsson, Vibhuti Shah, Kellie E. Murphy, Eileen Hutton, Christine Newburn-Cook, Corine Frick, Fran Scott, Victoria Allen, and John D. Cameron
- Subjects
Pediatrics ,medicine.medical_specialty ,MEDLINE ,Gestational Age ,Weight Gain ,Pregnancy ,Risk Factors ,medicine ,Humans ,Maternal Welfare ,Obstetrics ,business.industry ,Infant, Newborn ,Obstetrics and Gynecology ,Gestational age ,Infant, Low Birth Weight ,medicine.disease ,Low birth weight ,Meta-analysis ,Cohort ,Premature Birth ,Gestation ,Female ,medicine.symptom ,business ,Weight gain - Abstract
Many women have high gestational weight gain (GWG), but potential neonatal consequences are not yet well quantified. We sought to determine the relationship between high GWG and preterm birth (PTB) and low birth weight (LBW) in singleton births.We searched Medline and Embase and reference lists.Two assessors independently performed all steps. We selected studies assessing high total or weekly GWG on PTB (37 weeks) and LBW (2500 grams).Thirty-eight studies, 24 cohort and 14 case-control, were included involving 2 124 907 women. Most contained unadjusted data. Women with high total GWG had a decreased risk overall of PTB37 weeks (relative risk [RR] 0.75; 95% CI 0.60 to 0.96), PTB 32 to 36 weeks (RR 0.70; 95% CI 0.70 to 0.71), and32 weeks (RR 0.87; 95% CI 0.85 to 0.90). High GWG was associated with lower risk of LBW (RR 0.64; 95% CI 0.53 to 0.78). Women with the highest GWG had lower risks of LBW (RR 0.55; 95% CI 0.32 to 0.94) than women with moderately high GWG (RR 0.73; 95% CI 0.60 to 0.89). Women with the highest weekly GWG had greater risks of PTB (RR 1.51; 95% CI 1.47 to 1.55) than women with moderately high weekly GWG (RR 1.09; 95% CI 1.05 to 1.13). Women with high weekly GWG were at increased risk of PTB 32 to 36 weeks (RR 1.14; 95% CI 1.10 to 1.17 and32 weeks (RR 1.81; 95% CI 1.73 to 1.90).Although women with high total GWG have lower unadjusted risks of PTB and LBW, high weekly GWG is associated with increased PTB, and more adjusted studies are needed, as are more studies in obese women. Potential benefits of high GWG for the infant must be balanced against maternal risks and other known infant risks such as high birth weight.
- Published
- 2011
27. Additional file 1: of Differences in perinatal and infant mortality in high-income countries: artifacts of birth registration or evidence of true differences?
- Author
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Paromita Deb-Rinker, León, Juan, Gilbert, Nicolas, Rouleau, Jocelyn, Andersen, Anne-Marie, Bjarnadóttir, Ragnheiður, Gissler, Mika, Laust Mortensen, Skjærven, Rolv, Vollset, Stein, Zhang, Xun, Prakesh Shah, Sauve, Reg, Kramer, Michael, and K. Joseph
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STROBE Statement—checklist of items that should be included in reports of observational studies. (DOC 84 kb)
- Published
- 2015
- Full Text
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28. Effect of induction of meconium evacuation using per rectal laxatives on neonatal hyperbilirubinemia in term infants: a systematic review of randomized controlled trials
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Ravisha, Srinivasjois, Ajay, Sharma, Prakesh, Shah, and Maina, Kava
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Meconium ,Administration, Rectal ,Laxatives ,Infant, Newborn ,Humans ,Enema ,Hyperbilirubinemia, Neonatal ,Randomized Controlled Trials as Topic - Abstract
To study the efficacy of early meconium evacuation using per rectal laxatives on the level of serum bilirubin and the need for phototherapy in healthy term infants.Systematic review of randomized controlled trials comparing per rectal laxatives versus no intervention was conducted using English language articles identified from the Cochrane Central Register of Controlled Trials, Medline, Ovid, and CINAHL databases and bibliographies of selected articles. Eligible studies were assessed for the risk of bias in conduct and reporting.A total of three trials (n = 469) mostly with "unclear risk" were eligible for inclusion. Two trials used glycerin suppository whereas one used glycerin enema for meconium evacuation. Meta-analysis was not possible due to clinical heterogeneity in the choice of laxatives and frequency of intervention. In all the three studies, serum bilirubin levels at 48 h and the need for phototherapy was not significantly different between the two groups. Passage of first meconium and the transitional stools occurred significantly early in the intervention group compared to controls.Early evacuation of meconium using per rectal laxatives does not offer any significant clinical advantage for neonatal jaundice.
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- 2013
29. Determinants of developmental outcomes in a very preterm Canadian cohort
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Anne, Synnes, Thuy Mai, Luu, Diane, Moddemann, Paige, Church, David, Lee, Michael, Vincer, Marilyn, Ballantyne, Annette, Majnemer, Dianne, Creighton, Junmin, Yang, Reginald, Sauve, Saroj, Saigal, Prakesh, Shah, Shoo K, Lee, and Phil, Murphy
- Subjects
Male ,Canada ,medicine.medical_specialty ,Pediatrics ,Developmental Disabilities ,Vision Disorders ,Gestational Age ,National cohort ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Acquired immunodeficiency syndrome (AIDS) ,Risk Factors ,030225 pediatrics ,medicine ,Humans ,Bilateral visual impairment ,Prospective Studies ,030212 general & internal medicine ,Hearing Disorders ,business.industry ,Cerebral Palsy ,Infant, Newborn ,Obstetrics and Gynecology ,General Medicine ,medicine.disease ,Very preterm ,Infant, Extremely Premature ,Pediatrics, Perinatology and Child Health ,Cohort ,Female ,Outcomes research ,business - Abstract
Identify determinants of neurodevelopmental outcome in preterm children.Prospective national cohort study of children born between 2009 and 2011 at29 weeks gestational age, admitted to one of 28 Canadian neonatal intensive care units and assessed at a Canadian Neonatal Follow-up Network site at 21 months corrected age for cerebral palsy (CP), visual, hearing and developmental status using the Bayley Scales of Infant and Toddler Development-Third Edition (Bayley-III). Stepwise regression analyses evaluated the effect of (1) prenatal and neonatal characteristics, (2) admission severity of illness, (3) major neonatal morbidities, (4) neonatal neuroimaging abnormalities, and (5) site on neurodevelopmental impairment (NDI) (Bayley-III score85, any CP, visual or hearing impairment), significant neurodevelopmental impairment (sNDI) (Bayley-III70, severe CP, blind or hearing aided and sNDI or death.Of the 3700 admissions without severe congenital anomalies, 84% survived to discharge and of the 2340 admissions, 46% (IQR site variation 38%-51%) had a NDI, 17% (11%-23%) had a sNDI, 6.4% (3.1%-8.6%) had CP, 2.6% (2.5%-13.3%) had hearing aids or cochlear implants and 1.6% (0%-3.1%) had a bilateral visual impairment. Bayley-III composite scores of70 for cognitive, language and motor domains were 3.3%, 10.9% and 6.7%, respectively. Gestational age, sex, outborn, illness severity, bronchopulmonary dysplasia, necrotising enterocolitis, late-onset sepsis, retinopathy of prematurity, abnormal neuroimaging and site were significantly associated with NDI or sNDI. Site variation ORs for NDI, sNDI and sNDI/death ranged from 0.3-4.3, 0.04-3.5 and 0.12-1.96, respectively.Most preterm survivors are free of sNDI. The risk factors, including site, associated with neurodevelopmental status suggest opportunities for improving outcomes.
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- 2016
30. Multidisciplinary perinatal management of the compromised airway on placental support: lessons learned
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Alexander J, Osborn, David, Baud, Alison J, Macarthur, Evan J, Propst, Vito, Forte, Susan M, Blaser, Rory, Windrim, Gareth, Seaward, Johannes, Keunen, Prakesh, Shah, Greg, Ryan, and Paolo, Campisi
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Adult ,Patient Care Team ,Placenta ,Infant, Newborn ,Delivery, Obstetric ,Infant, Newborn, Diseases ,Airway Obstruction ,Cohort Studies ,Fetal Diseases ,Perinatal Care ,Young Adult ,Treatment Outcome ,Pregnancy ,Humans ,Female ,Interdisciplinary Communication ,Life Support Systems ,Retrospective Studies - Abstract
The aims of this study were to review fetal and maternal outcomes after management of the compromised perinatal airway via operation on placental support or ex utero intrapartum treatment and to discuss implications for future management of these complex and rare cases.We have presented a retrospective case series of 12 neonates requiring airway management on placental support at a single tertiary care, academic center.One mother experienced significant blood loss. Operative recovery times were unremarkable. Eight neonates required airway management due to mass obstruction, two for removal of an endotracheal balloon for fetoscopic treatment of congenital diaphragmatic hernia, one for laryngeal atresia, and one for severe retrognathia. One of our series is an unusual case of management on placental support after vaginal delivery. Another child would have ideally been managed on placental support, but an extremely short umbilical cord prevented this. Even though the airway was secured in all 12 cases, five neonates died in the perinatal period.These procedures have a risk for substantial maternal blood loss. Despite excellent rates of success securing the neonatal airway, children who require management on placental support still have high mortality. A formalized multidisciplinary approach at our institution has enhanced preparedness for these cases.
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- 2012
31. Influence of definition based versus pragmatic birth registration on international comparisons of perinatal and infant mortality: population based retrospective study
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K S, Joseph, Shiliang, Liu, Jocelyn, Rouleau, Sarka, Lisonkova, Jennifer A, Hutcheon, Reg, Sauve, Alexander C, Allen, Michael S, Kramer, and Prakesh, Shah
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medicine.medical_specialty ,Birth weight ,Population ,Birth rate ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,CME ,Infant Mortality ,Medicine ,Humans ,030212 general & internal medicine ,education ,Perinatal Mortality ,General Environmental Science ,Retrospective Studies ,education.field_of_study ,Australasia ,business.industry ,Obstetrics ,Mortality rate ,Research ,Developed Countries ,General Engineering ,Infant, Newborn ,Gestational age ,Infant ,Retrospective cohort study ,General Medicine ,Infant mortality ,3. Good health ,Europe ,Epidemiologic Studies ,Infant, Extremely Low Birth Weight ,Birth Certificates ,North America ,Fetal Mortality ,General Earth and Planetary Sciences ,Premature Birth ,business ,Developed country ,Live Birth - Abstract
Objectives To examine variations in the registration of extremely low birthweight and early gestation births and to assess their effect on perinatal and infant mortality rankings of industrialised countries. Design Retrospective population based study. Setting Australia, Canada, European countries, and the United States for 2004; Australia, Canada, and New Zealand for 2007. Population National data on live births and on fetal, neonatal, and infant deaths. Main outcome measures Reported proportions of live births with birth weight/gestational age of less than 500 g, less than 1000 g, less than 24 weeks, and less than 28 weeks; crude rates of fetal, neonatal, and infant mortality; mortality rates calculated after exclusion of births under 500 g, under 1000 g, less than 24 weeks, and less than 28 weeks. Results The proportion of live births under 500 g varied widely from less than 1 per 10 000 live births in Belgium and Ireland to 10.8 per 10 000 live births in Canada and 16.9 in the United States. Neonatal deaths under 500 g, as a proportion of all neonatal deaths, also ranged from less than 1% in countries such as Luxembourg and Malta to 29.6% in Canada and 31.1% in the United States. Rankings of countries based on crude fetal, neonatal, and infant mortality rates differed substantially from rankings based on rates calculated after exclusion of births with a birth weight of less than 1000 g or a gestational age of less than 28 weeks. Conclusions International differences in reported rates of extremely low birthweight and very early gestation births probably reflect variations in registration of births and compromise the validity of international rankings of perinatal and infant mortality.
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- 2012
32. Ultrasound-guided laser treatment of hydropic fetal lung lesions with a systemic arterial supply
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Frans J.C.M. Klumper, Rory Windrim, Dick Oepkes, Greg Ryan, Jack Langer, Prakesh Shah, Murray Asch, Fawaz Alkazaleh, and Gareth Seaward
- Subjects
medicine.medical_specialty ,Pregnancy ,Fetus ,Lung ,Fetal surgery ,business.industry ,medicine.medical_treatment ,Obstetrics and Gynecology ,medicine.disease ,Shunt (medical) ,Surgery ,Diaphragm (structural system) ,medicine.anatomical_structure ,medicine ,Abdomen ,Cyst ,Radiology ,business - Abstract
LUNG LESIONS WITH A SYSTEMIC ARTERIAL SUPPLY GREG RYAN, DICK OEPKES, JACK LANGER, FAWAZ ALKAZALEH, MURRAY ASCH, FRANS KLUMPER, GARETH SEAWARD, RORY WINDRIM, PRAKESH SHAH, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada Leiden University Medical Center, Leiden, The Netherlands Hospital for Sick Children, University of Toronto, Toronto, Ontario OBJECTIVE: To report innovative minimally invasive fetal therapy for massive lung lesions associated with hydrops. STUDY DESIGN: 2 cases, followed prospectively. RESULTS: 2 hydropic fetuses, at 19 and 23 wks, respectively, had massive bronchopulmonary sequestrations occupyingmost of the chest and everting the diaphragm well into the abdomen. A large aortic feeding vessel was identified in each case. Using IV sedation and continuous ultrasound guidance, an 18g needle was placed intra-amniotically, through which a longer 22g needle was advanced into the fetal IHV to sample, paralyze, and anesthetize the fetus. This was then redirected into one of the larger cysts, and microbubble contrast agent (Levovist) was injected to document cyst communication. A 600-micron ND: YAG laser fiber was passed through the 18g needle, and the tip was placed adjacent to the feeding vessel, which was successfully ablated in each case. In the first case at 19 wks, finally a fetal Rocket pleuroamniotic shunt was placed, traversing several cysts. The left-sided mass resolved dramatically in size over the next 3 wks, and hydrops resolved completely. A healthy 3.7-kgmale, requiring no assisted ventilation, was born at 39 wks. The involved lobe was resected the next day; pediatric follow-up is entirely normal. At 23 wks, GA was used for the 2nd right-sided mass and no shunt was placed: 2 wks later, there has been some mass shrinkage; so far, hydrops persists. The pregnancy is ongoing. CONCLUSION: The prognosis for large fetal cystic chest masses associated with hydrops is dismal—all die. This has prompted attempts at treatment by open fetal surgery, with mixed results and a high risk of premature labor. We have demonstrated an excellent outcome by US-guided laser ablation of the systemic arterial supply. This is a preferable, much less invasive approach to such lesions—with far less risk of premature labor. A fetal pleuroamniotic shunt may have a beneficial adjunctive effect.
- Published
- 2003
33. High frequency oscillatory ventilation was not more effective than conventional ventilation in preterm infants
- Author
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Prakesh Shah and Carol M. Cheng
- Subjects
medicine.medical_specialty ,Neurological injury ,business.industry ,Medicine ,Fundamentals and skills ,Infant health ,Neonatal health ,business ,Intensive care medicine ,Child health ,High frequency oscillatory ventilation ,Conventional ventilation - Published
- 2003
34. The Changing Epidemiology of Preterm Twins and Triplets Admitted to Neonatal Intensive Care Units in Canada, 2003 to 2008.
- Author
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Kate Bassil, Prakesh Shah, Keith Barrington, Adele Harrison, Orlando da Silva, and Shoo Lee
- Abstract
We describe trends in the rates of admission of preterm twin and triplet infants to neonatal intensive care units (NICUs) across Canada and compare their neonatal outcomes over a 6-year period. Temporal trends of admission rates for 5193 twins and triplets < 33 weeks' gestational age to participating NICUs in the Canadian Neonatal Network between 2003 and 2008 were assessed. Trends in infant outcomes were evaluated using logistic regression. The proportion of twins increased from 26.1 to 28.0 per 100 admissions between 2003 and 2008 (7% increase, p = 0.02). In contrast, the proportion of triplets decreased from 5.0 to 3.3 per 100 admissions (34% reduction, p = 0.04). These trends were significant in mothers â¥Â 35 years of age. Neonatal outcomes improved for preterm twins (mortality, p <  0.01; survival without any major morbidity, p <  0.01; severe neurological injury, p = 0.02; and severe retinopathy of prematurity, p = 0.03). Similar improvements were observed for triplets, but the sample size was insufficient to reach statistical significance. The rate of NICU admissions for preterm twins at < 33 weeks' gestation has increased in recent years, whereas for triplets it has gradually declined. Neonatal outcomes of preterm twins improved over the study period. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
35. Neonatal Outcomes of Small for Gestational Age Preterm Infants in Canada.
- Author
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Xiangming Qiu, Abhay Lodha, Prakesh Shah, K. Sankaran, Mary Seshia, Wendy Yee, Ann Jefferies, and Shoo Lee
- Abstract
To compare the effect of small for gestational age (SGA) on mortality, major morbidity and resource utilization among singleton very preterm infants (<33 weeks gestation) admitted to neonatal intensive care units (NICUs) across Canada. Infants admitted to participating NICUs from 2003 to 2008 were divided into SGA (defined as birth weight <10th percentile for gestational age and sex) and non-small gestational age (non-SGA) groups. The risk-adjusted effects of SGA on neonatal outcomes and resource utilization were examined using multivariable analyses. SGA infants (n = 1249 from a cohort of 11,909) had a higher odds of mortality (adjusted odds ratio [AOR] 2.46; 95% confidence interval [CI], 1.93–3.14), necrotizing enterocolitis (AOR 1.57; 95% CI, 1.22–2.03), bronchopulmonary dysplasia (AOR 1.78; 95% CI, 1.48–2.13), and severe retinopathy of prematurity (AOR 2.34; 95% CI, 1.71–3.19). These infants also had lower odds of survival free of major morbidity (AOR 0.50; 95% CI, 0.43–0.58) and respiratory distress syndrome (AOR 0.79; 95% CI, 0.68–0.93). In addition, SGA infants had a more prolonged stay in the NICU, and longer use of ventilation continuous positive airway pressure, and supplemental oxygen (p < 0.01 for all). SGA infants had a higher risk of mortality, major morbidities, and higher resource utilization compared with non-SGA infants. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
36. Time Courses of Intrapartum Asphyxia: Neonatal Characteristics and Outcomes.
- Author
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Prakesh Shah
- Subjects
- *
ISCHEMIA , *ASPHYXIA , *RESPIRATORY diseases , *NEWBORN infants - Abstract
We compared neonatal characteristics and adverse outcome rates of neonates with hypoxic-ischemic encephalopathy following (1) prolonged partial asphyxia, (2) acute near-total intrapartum asphyxia, and (3) the two combined. The time course of the insult was determined individually by two authors from obstetric data and neonatal charts. "Severe adverse outcome" was defined as death or severe disability detectable by age 2 years. The asphyxial time course was prolonged partial asphyxia in 167 (45%), acute near-total asphyxia in 96 (26%), combined in 78 (21%), and indeterminate in 34 (8%) patients. Among patients with known time course and outcomes, 212 (67%) had severe adverse outcome and 103 (33%) were free of severe adverse outcome. Severe adverse outcome rates were 61% for prolonged partial asphyxia, 67% for acute near-total asphyxia, and 79% for combined time course asphyxia ( P?=?0.025). Long-term outcomes differ according to the time course of the insult; infants with combined time course had the worst outcome. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
37. Additional file 1: Table S1. of Comparing very low birth weight versus very low gestation cohort methods for outcome analysis of high risk preterm infants
- Author
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Koller-Smith, Louise, Prakesh Shah, Ye, Xiang, Sjörs, Gunnar, Yueping Wang, Chow, Sharon, Darlow, Brian, Shoo Lee, Håkanson, Stellan, and Lui, Kei
- Subjects
3. Good health - Abstract
Consensus definitions of important variables. Definitions of neonatal outcomes with consensus definitions agreed upon by the CNN, ANZNN and SNQ. Table S2: Stratified outcomes between networks. (a): Unadjusted perinatal risks, mortality and major neonatal morbidities among SNQ, ANZNN and CNN infants during 2008–2011 by gestational age groups. (b): Unadjusted perinatal risks, mortality and major neonatal morbidities among SNQ, ANZNN and CNN infants during 2008–2011 by birth weight groups. Table S3: Cross comparison of predictive power of very low birth weight (VLBW) and very low gestational age (VLGA) based models. Table S4: Comparisons of infant and perinatal characteristics and neonatal outcomes among networks (ANZNN, CNN, SNQ) for the 2 extreme components of the very low gestational age cohort and very low birth weight cohort 2008–2011 admissions [25–27, 57–59]. (DOC 174 kb)
38. Additional file 1: Table S1. of Comparing very low birth weight versus very low gestation cohort methods for outcome analysis of high risk preterm infants
- Author
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Koller-Smith, Louise, Prakesh Shah, Ye, Xiang, Sjörs, Gunnar, Yueping Wang, Chow, Sharon, Darlow, Brian, Shoo Lee, Håkanson, Stellan, and Lui, Kei
- Subjects
3. Good health - Abstract
Consensus definitions of important variables. Definitions of neonatal outcomes with consensus definitions agreed upon by the CNN, ANZNN and SNQ. Table S2: Stratified outcomes between networks. (a): Unadjusted perinatal risks, mortality and major neonatal morbidities among SNQ, ANZNN and CNN infants during 2008–2011 by gestational age groups. (b): Unadjusted perinatal risks, mortality and major neonatal morbidities among SNQ, ANZNN and CNN infants during 2008–2011 by birth weight groups. Table S3: Cross comparison of predictive power of very low birth weight (VLBW) and very low gestational age (VLGA) based models. Table S4: Comparisons of infant and perinatal characteristics and neonatal outcomes among networks (ANZNN, CNN, SNQ) for the 2 extreme components of the very low gestational age cohort and very low birth weight cohort 2008–2011 admissions [25–27, 57–59]. (DOC 174 kb)
39. CPAP vs NIPPV: A COMPARATIVE EFFECTIVENESS RESEARCH
- Author
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MOUNT SINAI HOSPITAL, Canadian Institutes of Health Research (CIHR), and Prakesh Shah, Director
- Published
- 2023
40. High frequency oscillatory ventilation was not more effective than conventional ventilation in preterm infants.
- Author
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Carol Cheng and Prakesh Shah
- Published
- 2003
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