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2. Development of a real-time tritium-in-water monitor

Author

Azevedo, C. D. R., Baeza, A., Chauveau, E., Corbacho, J. A., Díaz, J., Domange, J., Marquet, C., Martínez-Roig, M., Piquemal, F., Prado, D., Veloso, J. F. C. A., and Yahlali, N.

Subjects
Physics - Instrumentation and Detectors
Abstract

In this paper, we report the development and performance of a detector module envisaging a tritium-in-water real-time activity monitor. The monitor is based on modular detection units whose number can be chosen according to the required sensitivity. The full system is being designed to achieve a \emph{Minimum Detectable Activity} (\emph{MDA}) of 100\,Bq/L of tritium-in-water activity which is the limit established by the E.U. Council Directive 2013/51/Euratom for water intended for human consumption. The same system can be used as a real-time pre-alert system for nuclear power plant regarding tritium-in water environmental surveillance. The first detector module was characterized, commissioned and installed immediately after the discharge channel of the Arrocampo dam (Almaraz nuclear power plant, Spain) on the Tagus river. Due to the high sensitivity of the single detection modules, the system requires radioactive background mitigation techniques through the use of active and passive shielding. We have extrapolated a \emph{MDA} of 3.6\,kBq/L for a single module being this value limited by the cosmic background. The obtained value for a single module is already compatible with a real-time environmental surveillance and pre-alert system. Further optimization of the single-module sensitivity will imply the reduction of the number of modules and the cost of the detector system., Comment: 10 pages, 16 figures

Published
2022

5. Final results from the PERUSE study of first-line pertuzumab plus trastuzumab plus a taxane for HER2-positive locally recurrent or metastatic breast cancer, with a multivariable approach to guide prognostication

Author

Bachelot, T., Bouzid, K., Campone, M., Desmoulins, I., Coudert, B., Bondarenko, I., Nowecki, Z., Glogowska, I., Ciruelos Gil, E., Errihani, H., Dalenc, F., Ricci, F., Dieras, V., Kaufman, B., Paluch-Shimon, S., Wardley, A., Schneeweiss, A., Ferreira, A., Mano, M., Kalofonos, H., Andreetta, C., Puglisi, F., Montemurro, F., Barrett, S., Zhang, Q., Mavroudis, D., Matus, J., Villarreal Garza, C., Beato, C., Ismael, G., Hu, X., Abdel Azeem, H., Gaafar, R., Perrin, C., Kerbrat, P., Ettl, J., Paepke, S., Hitre, E., Lang, I., Trudeau, M., Verma, S., Li, H., Hoffmann, O., Aktas, B., Cariello, A., Cruciani, G., Tienghi, A., Tondini, C., Al-Twegieri, T., Loman, N., Laing, R., Miles, D., Brain, E., Fasching, P., Lux, M., Frassoldati, A., Aziz, Z., Salas, J., Streb, J., Krzemieniecki, K., Wronski, A., Garcia Garcia, J., Menjon Beltran, S., Cicin, I., Schmid, P., Gallagher, C., Turner, N., Tong, Z., Boer, K., Juhász, B., Horvath, Z., Bianchini, G., Gianni, L., Curigliano, G., Juarez Ramiro, A., Susnjar, S., Matos, E., Sevillano, E., Garcia Estevez, L., Gokmen, E., Uslu, R., Wildiers, H., Schutz, F., Cruz, M., Bourgeois, H., von Schumann, R., Stemmer, S., Dominguez, A., Morales-Vásques, F., Wojtukiewicz, M., Trifunovic, J., Echarri Gonzalez, M.J., Illarramendi Mañas, J., Martinez De Dueñas, E., Voitko, N., Hicks, J., Waters, S., Barrett-Lee, P., Wheatley, D., De Boer, R., Cocquyt, V., Jerusalem, G., Barrios, C., Panasci, L., Mattson, J., Tanner, M., Gozy, M., Vasilopoulos, G., Papandreou, C., Revesz, J., Battelli, N., Benedetti, G., Latini, L., Gridelli, C., Lazaro Leon, J., Alarcón Company, J., Arance Fernandez, A., Barnadas Molins, A., Calvo Plaza, I., Bratos, R., Gonzalez Martin, A., Izarzugaza Peron, Y., Klint, L., Kovalev, A., McCarthy, N., Yeo, B., Kee, D., Thomson, J., White, S., Greil, R., Wang, S., Artignan, X., Juhasz-Böess, I., Rody, A., Ngan, R., Dourleshter, F., Goldberg, H., Doni, L., Di Costanzo, F., Ferraù, F., Drobniene, M., Aleknavicius, E., Rashid, K., Costa, L., de la Cruz Merino, L., Garcia Saenz, J., López, R., Del Val Munoz, O., Ozyilkan, O., Azribi, F., Jaafar, H., Baird, R., Verrill, M., Beith, J., Petzer, A., Moreira de Andrade, J., Bernstein, V., Macpherson, N., Rayson, D., Saad Eldin, I., Achille, M., Augereau, P., Müller, V., Rasco, A., Evron, E., Katz, D., Berardi, R., Cascinu, S., De Censi, A., Gennari, A., El-Saghir, N., Ghosn, M., Oosterkamp, H.M., Van den Bosch, J., Kukulska, M., Kalinka, E., Alonso, J., Dalmau Portulas, E., Del Mar Gordon Santiago, M., Pelaez Fernandez, I., Aksoy, S., Altundag, K., Senol Coskun, H., Bozcuk, H., Shparyk, Y., Barraclough, L., Levitt, N., Panwar, U., Kelly, S., Rigg, A., Varughese, M., Castillo, C., Fein, L., Malik, L., Stuart-Harris, R., Singer, C., Stoeger, H., Samonigg, H., Feng, J., Cedeño, M., Ruohola, J., Berdah, J.-F., Goncalves, A., Orfeuvre, H., Grischke, E.-M., Simon, E., Wagner, S., Koumakis, G., Papazisis, K., Ben Baruch, N., Fried, G., Geffen, D., Karminsky, N., Peretz, T., Cavanna, L., Pedrazzioli, P., Grasso, D., Ruggeri, E., D’Auria, G., Moscetti, L., Juozaityte, E., Rodriguez Cid, J., Roerdink, H., Siddiqi, N., Passos Coelho, J., Arcediano Del Amo, A., Garcia Garre, E., García Gonzalez, M., Garcia-Palomo Perez, A., Herenandez Perez, C., Lopez Alvarez, P., Lopez De Ceballos, M.H., Martínez Jañez, N., Mele Olive, M., McAdam, K., Perren, T., Dunn, G., Humphreys, A., Taylor, W., Vera, R., Kaen, L., Andel, J., Steger, G., De Grève, J., Huizing, M., Hegg, R., Joy, A., Kuruvilla, P., Sehdev, S., Smiljanic, S., Kütner, R., Alexandre, J., Grosjean, J., Laplaige, P., Largillier, R., Maes, P., Martin, P., Pottier, V., Christensen, B., Khandan, F., Lück, H.-J., Zahm, D.-M., Fountzilas, G., Karavasilis, V., Safra, T., Inbar, M., Ryvo, L., Bonetti, A., Seles, E., Giacobino, A., Chavarri Guerra, Y., de Jongh, F., van der Velden, A., van Warmerdam, L., Vrijaldenhoven, S., Smorenburg, C.H., Cavero, M., Andres Conejero, R., Oltra Ferrando, A., Redondo Sanchez, A., Ribelles Entrena, N., Saura Grau, S., Viñas Vilaro, G., Bachmeier, K., Beresford, M., Butt, M., Joffe, J., Poole, C., Woodings, P., Chakraborti, P., Yordi, G., Woodward, N., Nobre, A., Luiz Amorim, G., Califaretti, N., Fox, S., Robidoux, A., Li, E., Li, N., Jiang, J., Soria, T., Padrik, P., Lahdenpera, O., Barletta, H., Dohollou, N., Genet, D., Prulhiere, K., Coeffic, D., Facchini, T., Vieillot, S., Catala, S., Teixeira, L., Hesse, T., Kühn, T., Ober, A., Repp, R., Schröder, W., Pectasides, D., Bodoky, G., Kahan, Z., Jiveliouk, I., Rosengarten, O., Rossi, V., Alabiso, O., Pérez Martínez, M., van de Wouw, A.J., Smok-Kalwat, J., Damasecno, M., Augusto, I., Sousa, G., Saadein, A., Abdelhafiez, N., Abulkhair, O., Antón Torres, A., Corbellas Aparicio, M., Llorente Domenech, R., Florián Jerico, J., Garcia Mata, J., Gil Raga, M., Galan Brotons, A., Llombart Cussac, A., Llorca Ferrandiz, C., Martinez Del Prado, P., Olier Garate, C., Rodriguez Sanchez, C., Sanchez Gomez, R., Santisteban Eslava, M., Soberino, J., Vidal Losada Garcia, M., Soto de Prado, D., Torrego Garcia, J., Vicente Rubio, E., Garcia, M., Murias Rosales, A., Granstam Björneklett, H., Narbe, U., Jafri, M., Rea, D., Newby, J., Jones, A., Westwell, S., Ring, A., Alonso, I., Rodríguez, R., Ciruelos, E., Peretz-Yablonski, T., Merot, J.-L., Trask, P., du Toit, Y., Pena-Murillo, C., Revelant, V., and Klingbiel, D.

Published
2021
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8. Multiple approaches for large-scale CO2 capture by adsorption with 13X zeolite in multi-stage fluidized beds assessment.

Author

Prado, D. S., Vilarrasa-García, E., Sampronha, E., Beleli, Y. S., Moreira, F. S., Paiva, J. L., Roux, G. A. C. L., Bastos-Neto, M., Azevedo, D. C. S., Silva, E. C. N., and Seckler, M. M.

Abstract

Adsorption is a promising technology for reducing CO2 emissions from combustion gases. However, some issues must be considered when designing large-scale units with low environmental impact and cost. In this contribution, some of these issues are addressed. Firstly, sugarcane bagasse is selected as a meaningful model system. 13XBF Kostrolith zeolite is used as the adsorbent, and adsorption equilibrium data are determined using a magnetic suspension balance from Rubotherm. 13XBF showed a high CO2 capacity and CO2/N2 selectivity under post-combustion scenario conditions. Secondly, the fluidized bed process was optimized using a 3-stage adsorber and a 3-stage desorber, with heat exchangers that can be used in each stage. The constrained variable in the adsorption column is the solid-to-gas mass feed ratios. It was found that substantial CO2 recovery with 98% purity can be achieved and that the heat load in the desorption column accounts for the highest energy-optimized cost in the process. Thirdly, a detailed CFD model for the fluid dynamics and heat transfer of fluidization for one stage is presented. Bubbles were defined using a hyperbolic filter as predicted by the model, which was consistent with the semi-empirical model and emphasized the significance of bubble size in gas–solid heat transfer, which is essential to the effectiveness of adsorption/desorption. The bubble portion and its effects on the temperature are estimated. Finally, a semi-empirical approach is applied to understanding the controlling factors in a fluidized bed adsorption stage. Results show that the mass transfer from the bubbles to the emulsion is likely the most important resistance to the fluidized adsorber. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Development of a real-time tritium-in-water monitor

Author

Azevedo, C.D.R., primary, Baeza, A., additional, Chauveau, E., additional, Corbacho, J.A., additional, Díaz, J., additional, Domange, J., additional, Marquet, C., additional, Martínez-Roig, M., additional, Piquemal, F., additional, Prado, D., additional, Veloso, J.F.C.A., additional, and Yahlali, N., additional

Published
2023
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11. DESENVOLVIMENTO BRASIL 2035: o país que queremos

Author

FISCHMANN, A. A., primary, ANTUNES, A. M., additional, MONTEIRO, A. V. V. M., additional, Silva, Antônio Jacó da, additional, AULICINO, A. L., additional, BITTENCOURT, C., additional, KOBAYASHI, C. M. O., additional, PRADO, D. B., additional, SCHNEIDER, E. R., additional, Mendes, Enir Sebastião, additional, MARQUES, F. M. R., additional, SILVA, F. Q., additional, do Prado, Hércules Antonio, additional, TRABUCO, I., additional, TREVISAM NETO, J. A., additional, COSTA, J. A. V., additional, PAES DE LIMA, Lucinei, additional, Restier, Maria Inês Costa, additional, ABRANTES, Maria Luiza Marques de, additional, ZATI, M. S., additional, COSTA, Neuseli, additional, MARTINS, Renata, additional, Goldstajn, Roberto, additional, PEREIRA, Rubens C., additional, SILVA, Sheila Serafim da, additional, CARNEVALLI, S. S. A., additional, and FRANCA, T. J. F., additional

Published
2020
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16. Knowledge level regarding the prescription of antibiotics within the dentistry field

Author

Orellana-Alpala C, Pacheco-Quito E.-M, Calle-Prado D, Vélez-León E, and Cuenca-León K

Subjects
Knowledge, Anti-Bacterial Agents, Dental Staff, Students, Drug Prescriptions
Abstract

Antibiotic drugs represent a great tool in various dental treatments. However, their inappropriate use has been shown to negatively impact patients' health and the resistance of microorganisms, which can trigger future health crises. Objective: To determine dental students’ knowledge level regarding the prescription of antibiotics during the 2021-2022 period. Materials and Methods: This research was observational, descriptive, and current cross-sectional. The questionnaire consisted of 14 items. Scores from 0 to 5 were stated as a low level of knowledge, 6 to 10 as a medium, and 11 to 14 as high. Results: There was an association between the variables of academic semester level and the level of knowledge. In terms of gender, there was no association. Conclusion: Despite having an acceptable level of knowledge, there is evidence of the need to reinforce and refine it in students regarding the management of antibiotic medications.

Published
2022
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18. Network analyses of internet gaming disorder symptoms and their links with different types of motivation

Author

Gomez, R., Stavropoulos, V., Tullett-Prado, D., Schivinski, B., Chen, W., Gomez, R., Stavropoulos, V., Tullett-Prado, D., Schivinski, B., and Chen, W.

Abstract

The study used regularized partial correlation network analysis (EBICglasso) to examine the structure of DSM-5 internet gaming disorder (IGD) symptoms (network 1); and the associations of the IGD symptoms in the network with different types of motivation as defined in the self-determination theory i.e., intrinsic motivation (engaging in an activity for something unrelated to the activity), identified regulation (engaging in the activity because it aligns with one’s values and/or goals), external regulation (engagement in activity being driven by external rewards and/or approval), and amotivation (engaging in an activity without often understanding why) (network 2). Participants were 968 adults from the general community. They completed self-rating questionnaires covering IGD symptoms and different types of motivation. The findings for network 1 showed mostly positive connections between the symptoms within the IGD network. The most central symptom was loss of control, followed by continuation, withdrawal symptoms, and tolerance. In general, these symptoms were more strongly connected with each other than with the rest of the IGD symptoms. The findings for network 2 showed that the different types of motivation were connected differently with the different IGD symptoms. For instance, the likeliest motivation for the preoccupation and escape symptoms is intrinsic motivation, and for negative consequences, it is low identified regulation. Overall, the findings showed a novel understanding of the structure of the IGD symptoms, and the motivations underlying them. The clinical implications of the findings for assessment and treatment of IGD are discussed.

Published
2022

19. Development of a real-time tritium-in-water monitor

Author

Azevedo, C.D.R., Baeza, A., Chauveau, E., Corbacho, J.A., Díaz, J., Domange, J., Marquet, C., Martínez-Roig, M., Piquemal, F., Prado, D., Veloso, J.F.C.A., Yahlali, N., and HEP, INSPIRE

Subjects
Physics - Instrumentation and Detectors, [PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det)
Abstract

In this paper, we report the development and performance of a detector module envisaging a tritium-in-water real-time activity monitor. The monitor is based on modular detection units whose number can be chosen according to the required sensitivity. The full system must achieve a Minimum Detectable Activity (MDA) of 100\,Bq/L of tritium-in-water activity which is the limit established by the E.U. Council Directive 2013/51/Euratom for water intended for human consumption. The first detector module was characterized, commissioned and installed immediately after the discharge channel of the Arrocampo dam (Almaraz nuclear power plant, Spain) on the Tagus river. Due to the high sensitivity of the single detection modules, the system requires radioactive background mitigation techniques through the use of active and passive shielding. We have extrapolated a MDA of 3.6\,kBq/L for a single module being this value limited by the cosmic background. The obtained value for a single module is already compatible with a real-time pre-alert system for a nuclear power plant regarding tritium-in water environmental surveillance. Further optimization of the single-module sensitivity will imply the reduction of the number of modules and the cost of the detector system., 10 pages, 16 figures

Published
2022

24. Final results from the PERUSE study of first-line pertuzumab plus trastuzumab plus a taxane for HER2-positive locally recurrent or metastatic breast cancer, with a multivariable approach to guide prognostication

Author

Miles, D., primary, Ciruelos, E., additional, Schneeweiss, A., additional, Puglisi, F., additional, Peretz-Yablonski, T., additional, Campone, M., additional, Bondarenko, I., additional, Nowecki, Z., additional, Errihani, H., additional, Paluch-Shimon, S., additional, Wardley, A., additional, Merot, J.-L., additional, Trask, P., additional, du Toit, Y., additional, Pena-Murillo, C., additional, Revelant, V., additional, Klingbiel, D., additional, Bachelot, T., additional, Bouzid, K., additional, Desmoulins, I., additional, Coudert, B., additional, Glogowska, I., additional, Ciruelos Gil, E., additional, Dalenc, F., additional, Ricci, F., additional, Dieras, V., additional, Kaufman, B., additional, Ferreira, A., additional, Mano, M., additional, Kalofonos, H., additional, Andreetta, C., additional, Montemurro, F., additional, Barrett, S., additional, Zhang, Q., additional, Mavroudis, D., additional, Matus, J., additional, Villarreal Garza, C., additional, Beato, C., additional, Ismael, G., additional, Hu, X., additional, Abdel Azeem, H., additional, Gaafar, R., additional, Perrin, C., additional, Kerbrat, P., additional, Ettl, J., additional, Paepke, S., additional, Hitre, E., additional, Lang, I., additional, Trudeau, M., additional, Verma, S., additional, Li, H., additional, Hoffmann, O., additional, Aktas, B., additional, Cariello, A., additional, Cruciani, G., additional, Tienghi, A., additional, Tondini, C., additional, Al-Twegieri, T., additional, Loman, N., additional, Laing, R., additional, Miles, D., additional, Brain, E., additional, Fasching, P., additional, Lux, M., additional, Frassoldati, A., additional, Aziz, Z., additional, Salas, J., additional, Streb, J., additional, Krzemieniecki, K., additional, Wronski, A., additional, Garcia Garcia, J., additional, Menjon Beltran, S., additional, Cicin, I., additional, Schmid, P., additional, Gallagher, C., additional, Turner, N., additional, Tong, Z., additional, Boer, K., additional, Juhász, B., additional, Horvath, Z., additional, Bianchini, G., additional, Gianni, L., additional, Curigliano, G., additional, Juarez Ramiro, A., additional, Susnjar, S., additional, Matos, E., additional, Sevillano, E., additional, Garcia Estevez, L., additional, Gokmen, E., additional, Uslu, R., additional, Wildiers, H., additional, Schutz, F., additional, Cruz, M., additional, Bourgeois, H., additional, von Schumann, R., additional, Stemmer, S., additional, Dominguez, A., additional, Morales-Vásques, F., additional, Wojtukiewicz, M., additional, Trifunovic, J., additional, Echarri Gonzalez, M.J., additional, Illarramendi Mañas, J., additional, Martinez De Dueñas, E., additional, Voitko, N., additional, Hicks, J., additional, Waters, S., additional, Barrett-Lee, P., additional, Wheatley, D., additional, De Boer, R., additional, Cocquyt, V., additional, Jerusalem, G., additional, Barrios, C., additional, Panasci, L., additional, Mattson, J., additional, Tanner, M., additional, Gozy, M., additional, Vasilopoulos, G., additional, Papandreou, C., additional, Revesz, J., additional, Battelli, N., additional, Benedetti, G., additional, Latini, L., additional, Gridelli, C., additional, Lazaro Leon, J., additional, Alarcón Company, J., additional, Arance Fernandez, A., additional, Barnadas Molins, A., additional, Calvo Plaza, I., additional, Bratos, R., additional, Gonzalez Martin, A., additional, Izarzugaza Peron, Y., additional, Klint, L., additional, Kovalev, A., additional, McCarthy, N., additional, Yeo, B., additional, Kee, D., additional, Thomson, J., additional, White, S., additional, Greil, R., additional, Wang, S., additional, Artignan, X., additional, Juhasz-Böess, I., additional, Rody, A., additional, Ngan, R., additional, Dourleshter, F., additional, Goldberg, H., additional, Doni, L., additional, Di Costanzo, F., additional, Ferraù, F., additional, Drobniene, M., additional, Aleknavicius, E., additional, Rashid, K., additional, Costa, L., additional, de la Cruz Merino, L., additional, Garcia Saenz, J., additional, López, R., additional, Del Val Munoz, O., additional, Ozyilkan, O., additional, Azribi, F., additional, Jaafar, H., additional, Baird, R., additional, Verrill, M., additional, Beith, J., additional, Petzer, A., additional, Moreira de Andrade, J., additional, Bernstein, V., additional, Macpherson, N., additional, Rayson, D., additional, Saad Eldin, I., additional, Achille, M., additional, Augereau, P., additional, Müller, V., additional, Rasco, A., additional, Evron, E., additional, Katz, D., additional, Berardi, R., additional, Cascinu, S., additional, De Censi, A., additional, Gennari, A., additional, El-Saghir, N., additional, Ghosn, M., additional, Oosterkamp, H.M., additional, Van den Bosch, J., additional, Kukulska, M., additional, Kalinka, E., additional, Alonso, J., additional, Dalmau Portulas, E., additional, Del Mar Gordon Santiago, M., additional, Pelaez Fernandez, I., additional, Aksoy, S., additional, Altundag, K., additional, Senol Coskun, H., additional, Bozcuk, H., additional, Shparyk, Y., additional, Barraclough, L., additional, Levitt, N., additional, Panwar, U., additional, Kelly, S., additional, Rigg, A., additional, Varughese, M., additional, Castillo, C., additional, Fein, L., additional, Malik, L., additional, Stuart-Harris, R., additional, Singer, C., additional, Stoeger, H., additional, Samonigg, H., additional, Feng, J., additional, Cedeño, M., additional, Ruohola, J., additional, Berdah, J.-F., additional, Goncalves, A., additional, Orfeuvre, H., additional, Grischke, E.-M., additional, Simon, E., additional, Wagner, S., additional, Koumakis, G., additional, Papazisis, K., additional, Ben Baruch, N., additional, Fried, G., additional, Geffen, D., additional, Karminsky, N., additional, Peretz, T., additional, Cavanna, L., additional, Pedrazzioli, P., additional, Grasso, D., additional, Ruggeri, E., additional, D’Auria, G., additional, Moscetti, L., additional, Juozaityte, E., additional, Rodriguez Cid, J., additional, Roerdink, H., additional, Siddiqi, N., additional, Passos Coelho, J., additional, Arcediano Del Amo, A., additional, Garcia Garre, E., additional, García Gonzalez, M., additional, Garcia-Palomo Perez, A., additional, Herenandez Perez, C., additional, Lopez Alvarez, P., additional, Lopez De Ceballos, M.H., additional, Martínez Jañez, N., additional, Mele Olive, M., additional, McAdam, K., additional, Perren, T., additional, Dunn, G., additional, Humphreys, A., additional, Taylor, W., additional, Vera, R., additional, Kaen, L., additional, Andel, J., additional, Steger, G., additional, De Grève, J., additional, Huizing, M., additional, Hegg, R., additional, Joy, A., additional, Kuruvilla, P., additional, Sehdev, S., additional, Smiljanic, S., additional, Kütner, R., additional, Alexandre, J., additional, Grosjean, J., additional, Laplaige, P., additional, Largillier, R., additional, Maes, P., additional, Martin, P., additional, Pottier, V., additional, Christensen, B., additional, Khandan, F., additional, Lück, H.-J., additional, Zahm, D.-M., additional, Fountzilas, G., additional, Karavasilis, V., additional, Safra, T., additional, Inbar, M., additional, Ryvo, L., additional, Bonetti, A., additional, Seles, E., additional, Giacobino, A., additional, Chavarri Guerra, Y., additional, de Jongh, F., additional, van der Velden, A., additional, van Warmerdam, L., additional, Vrijaldenhoven, S., additional, Smorenburg, C.H., additional, Cavero, M., additional, Andres Conejero, R., additional, Oltra Ferrando, A., additional, Redondo Sanchez, A., additional, Ribelles Entrena, N., additional, Saura Grau, S., additional, Viñas Vilaro, G., additional, Bachmeier, K., additional, Beresford, M., additional, Butt, M., additional, Joffe, J., additional, Poole, C., additional, Woodings, P., additional, Chakraborti, P., additional, Yordi, G., additional, Woodward, N., additional, Nobre, A., additional, Luiz Amorim, G., additional, Califaretti, N., additional, Fox, S., additional, Robidoux, A., additional, Li, E., additional, Li, N., additional, Jiang, J., additional, Soria, T., additional, Padrik, P., additional, Lahdenpera, O., additional, Barletta, H., additional, Dohollou, N., additional, Genet, D., additional, Prulhiere, K., additional, Coeffic, D., additional, Facchini, T., additional, Vieillot, S., additional, Catala, S., additional, Teixeira, L., additional, Hesse, T., additional, Kühn, T., additional, Ober, A., additional, Repp, R., additional, Schröder, W., additional, Pectasides, D., additional, Bodoky, G., additional, Kahan, Z., additional, Jiveliouk, I., additional, Rosengarten, O., additional, Rossi, V., additional, Alabiso, O., additional, Pérez Martínez, M., additional, van de Wouw, A.J., additional, Smok-Kalwat, J., additional, Damasecno, M., additional, Augusto, I., additional, Sousa, G., additional, Saadein, A., additional, Abdelhafiez, N., additional, Abulkhair, O., additional, Antón Torres, A., additional, Corbellas Aparicio, M., additional, Llorente Domenech, R., additional, Florián Jerico, J., additional, Garcia Mata, J., additional, Gil Raga, M., additional, Galan Brotons, A., additional, Llombart Cussac, A., additional, Llorca Ferrandiz, C., additional, Martinez Del Prado, P., additional, Olier Garate, C., additional, Rodriguez Sanchez, C., additional, Sanchez Gomez, R., additional, Santisteban Eslava, M., additional, Soberino, J., additional, Vidal Losada Garcia, M., additional, Soto de Prado, D., additional, Torrego Garcia, J., additional, Vicente Rubio, E., additional, Garcia, M., additional, Murias Rosales, A., additional, Granstam Björneklett, H., additional, Narbe, U., additional, Jafri, M., additional, Rea, D., additional, Newby, J., additional, Jones, A., additional, Westwell, S., additional, Ring, A., additional, Alonso, I., additional, and Rodríguez, R., additional

Published
2021
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29. Expanding tropical forest monitoring into Dry Forests: The DRYFLOR protocol for permanent plots

Author

Moonlight, P.W., Banda-R, K, Phillips, Olivier L., Dexter, Kyle G., Pennington, R.T., Baker, T.R., C. de Lima, H., Fajardo, L., González-M., Linares-Palomino, R., Lloyd, J., Nascimento, M, Prado, D, Quintana, C, Riina, Ricarda, Moonlight, P.W., Banda-R, K, Phillips, Olivier L., Dexter, Kyle G., Pennington, R.T., Baker, T.R., C. de Lima, H., Fajardo, L., González-M., Linares-Palomino, R., Lloyd, J., Nascimento, M, Prado, D, Quintana, C, and Riina, Ricarda

Abstract

Understanding of tropical forests has been revolutionized by monitoring in permanent plots. Data from global plot networks have transformed our knowledge of forests’ diversity, function, contribution to global biogeochemical cycles, and sensitivity to climate change. Monitoring has thus far been concentrated in rain forests. Despite increasing appreciation of their threatened status, biodiversity, and importance to the global carbon cycle, monitoring in tropical dry forests is still in its infancy. We provide a protocol for permanent monitoring plots in tropical dry forests. Expanding monitoring into dry biomes is critical for overcoming the linked challenges of climate change, land use change, and the biodiversity crisis.

Published
2021

30. 770P Tolerability and efficacy of trabectedin plus pegylated liposomal doxorubicin (PLD) in elderly patients with ovarian cancer (OC): GEICO 105-O study

Author

Rubio Perez, M.J., Manzano Fernández, A., De Sande González, L.M., Estevez Garcia, P., Gordon Santiago, M.D.M., Soto de Prado, D., Hernando Fernandez, B.A., Guerra Alia, E.M., Carbo Bague, A., Romero, I., Corbellas Aparicio, M., Gonzalez-Haba Martinez, A., Robles Barraza, C.E., Martinez-Garcia, J., and Gonzalez Martin, A.

Published
2023
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31. Epidemiology of Bone Fractures in the Hand in Adult Population Using the ICD-10 Classification.

Author

DOMINGUEZ-PRADO, D. M., FERRADAS-GARCIA, L., PEREZ-ALFONSO, E., BALVIS-BALVIS, P., LOPEZ-LOPEZ, J. A., and CASTRO-MENENDEZ, M.

Subjects
HAND injuries, BONE fractures, INTERNATIONAL Statistical Classification of Diseases & Related Health Problems, PHALANGES, INTERNAL fixation in fractures, CARPAL bones
Abstract

PURPOSE OF THE STUDY The purpose of this study was to conduct an epidemiological study of hand fractures in adult population. MATERIAL AND METHODS A retrospective observational study in a population of 470,000 habitants was performed. Over the course of three years, all patients over 16 years of age who were diagnosed with fracture or fracture-dislocation at the level of a carpal bone, metacarpal and/or phalange were included. These fractures were classified according to the International Classification of Diseases 10th edition (ICD-10). Incidence rates, along with gender and age distribution were also studied. RESULTS 1,267 patients with a total of 1,341 hand fractures were included. They represented 29.7% of all upper limb fractures and 7.6% of all traumatological emergencies involving a bone fracture during that period. The most frequent ICD-10 group was S62.3, with the fifth metacarpal as the most often affected bone (39.7%). The most frequent location at the level of the phalanges (S62.5) was the proximal third of the proximal phalanx of the fifth radius. The global incidence rate was 99 fractures per 100,000 persons/year. No seasonal variation was observed. Only 10.2% of hand fractures received surgical treatment. DISCUSSION Several epidemiological studies have been published on fractures in the hand, but none have used the ICD-10 classification. Although the distribution of our stratified sample by age and gender was similar to those previously published, the incidence rate in our study was much lower. We may possibly extrapolate our results to the rest of the Spanish population and even to the rest of the population of southern Europe, given the scarcity of epidemiological studies on this matter in these geographical areas. CONCLUSIONS The ICD-10 classification is useful for the description and classification of hand fractures. The most often affected group is that including metacarpals of the long fingers (S62.3), being the distal level of the fifth metacarpal in young male patients the most frequent one. Most fractures are treated conservatively and in case of surgical treatment, the preferred surgical techniques include K-wire fixation, interfragmentary compression screws and plate osteosynthesis. [ABSTRACT FROM AUTHOR]

Published
2022
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42. A cardiovascular risk score for hypertensive patients previously admitted to hospital

Author

Martínez-Díaz AM, Palazón-Bru A, Folgado-de la Rosa DM, Ramírez-Prado D, Llópez-Espinós P, Beneyto-Ripoll C, and Gil-Guillén VF

Subjects
hypertension, Models, cardiovascular, mobile applications
Abstract

BACKGROUND: Cardiovascular risk scales in hypertensive populations have limitations for clinical practice. AIMS: To develop and internally validate a predictive model to estimate one-year cardiovascular risk for hypertensive patients admitted to hospital. METHODS: Cohort study of 303 hypertensive patients admitted through the Emergency Department in a Spanish region in 2015-2017. The main variable was the onset of cardiovascular disease during follow-up. The secondary variables were: gender, age, educational level, family history of cardiovascular disease, Charlson score and its individual conditions, living alone, quality of life, smoking, blood pressure, physical activity and adherence to the Mediterranean diet. A Cox regression model was constructed to predict cardiovascular disease one year after admission. This was then adapted to a points system, externally validated by bootstrapping (discrimination and calibration) and implemented in a mobile application for Android. RESULTS: A total of 93 patients developed cardiovascular disease (30.7%) over a mean period of 1.68 years. The predictors in the points system were: gender, age, myocardial infarction, heart failure, peripheral arterial disease and daily activity (quality of life). The internal validation by bootstrapping was satisfactory. CONCLUSION: A novel points system was developed to predict short-term cardiovascular disease in hypertensive patients after hospital admission. External validation studies are needed to corroborate the results obtained.

Published
2019

43. A one-year risk score to predict all-cause mortality in hypertensive inpatients

Author

Martínez-Díaz AM, Palazón-Bru A, Folgado-de la Rosa DM, Ramírez-Prado D, Navarro-Juan M, Pérez-Ramírez N, and Gil-Guillén VF

Subjects
Statistical, Death, Hypertension, Mobile applications, Models, Inpatients, Mortality
Abstract

The aim of this study was to construct and internally validate a scoring system to estimate the probability of death in hypertensive inpatients. Existing predictive models do not meet all the indications for clinical application because they were constructed in patients enrolled in clinical trials and did not use the recommended statistical methodology. This cohort study comprised 302 hypertensive patients hospitalized between 2015 and 2017 in Spain. The main variable was time-to-death (all-cause mortality). Secondary variables (potential predictors of the model) were: age, gender, smoking, blood pressure, Charlson Comorbidity Index (CCI), physical activity, diet and quality of life. A Cox model was constructed and adapted to a points system to predict mortality one year from admission. The model was internally validated by bootstrapping, assessing both discrimination and calibration. The system was integrated into a mobile application for Android. During the study, 63 patients died (20.9%). The points system prognostic variables were: gender, CCI, personal care and daily activities. Internal validation showed good discrimination (mean C statistic of 0.76) and calibration (observed probabilities adjusted to predicted probabilities). In conclusion, a points system was developed to determine the one-year mortality risk for hypertensive inpatients. This system is very simple to use and has been internally validated. Clinically, we could monitor more closely those patients with a higher risk of mortality to improve their prognosis and quality of life. However, the system must be externally validated to be applied in other geographic areas.

Published
2019

49. The Rietputs Formation in South Africa: A Pleistocene Fluvial Archive of Meteorite Impact Unique to the Kaapvaal Craton

Author

Cavosie, Aaron, Erickson, T., Montalvo, P., Prado, D., Cintron, N., Gibbon, R., Cavosie, Aaron, Erickson, T., Montalvo, P., Prado, D., Cintron, N., and Gibbon, R.

Abstract

Reconstructing the terrestrial impact cratering record is a fundamental goal of planetary science. However, erosion, burial, and deformation can obscure or destroy impact records. A sedimentary record of impact is provided by detrital shocked minerals, which have been shown to survive erosion and transport in modern alluvium and Holocene glacial deposits. Here we describe detrital shocked minerals from a known impact structure in sediments that were transported to distal locations and buried. The Rietputs Formation is a Pleistocene fluvial terrace of the Vaal River in South Africa, and shocked minerals were found in the terrace at locations up to 750 km downstream of the 2020 Ma Vredefort impact structure. Optical and electron microscopy, and U-Pb geochronology, were used to establish microstructural and isotopic provenance indicators that demonstrate the detrital shocked minerals originated from the Vredefort impact structure. The Rietputs Formation contains fluvial diamonds and Acheulean (ca. 1.7–1.3 Ma) artifacts at sites such as Canteen Kopje, a South African National Monument. The assemblage of detritus in Rietputs Formation gravels, including shocked minerals from Earth’s largest impact structure, diamonds from Cretaceous kimberlites, and Stone Age artifacts, comprises a unique sedimentary archive of the Kaapvaal craton, and may have geoheritage significance.

Published
2018

50. Apendicitis Agudas.- Criterios Doctrinales Diagnósticos

Author

Prado D., Carlos

Subjects
Apendicitis
Abstract

La apendicitis constituye uno de los temas de perenne actualidad dentro del vasto panorama de la patología humana, debido al notable porcentaje con que se presenta en todas las zonas habitadas por el hombre.Por esta razón su estudio, observación clínico, modalidades y forma de tratamiento, están constantemente revisadas y expuestas por los clínicos y dos cirujanos", según aifinma el Dr. Víllafañe en su trabajo.

Published
2017

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