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For a natural number $n\geq 2$, the function $\phi_{n\mathcal{L}}(z)=1+nz/(n+1)+z^n/(n+1)$ maps the open unit disk onto a domain bounded by an epicycloid with $(n-1)$ cusps. A class of starlike functions associated with $\phi_{n\mathcal{L}}$ is defined in the unit disk and its sharp bounds on initial coefficients, various inclusion relations and radii problems related to the other subclasses of starlike functions are investigated. As an application, the corresponding results are determined in the limiting case for the class of normalized analytic functions $f$ satisfying $|zf'(z)/f(z)-1

Infertility is one of the predominant health issues, affecting 10-15% of reproductive- aged couples. An infertility evaluation should be considered in any couple that has failed to conceive in one year. Infertility can be subdivided into primary infertility (no prior conception) and secondary infertility (infertility following at least 1 prior conception). Here it is the case of primary infertility. In Ayurveda it can be correlated with Anaptaya Vandhya (that is who never has conceived) and Apraja Vandhya (that lady who never have conceived but can conceive by eliminating the underlying cause). In this case study, Ayurvedic management successfully treat the primary infertility. Main clinical finding: A married Hindu female patient of 28 years of age visited to OPD of National institute of Ayurveda, Jaipur on 24 October 2020 with chief complaint of wants issue since 3 years. She had associated complaint of sometimes milk like discharge from breast since 3 years. Diagnosis: Her HSG scan suggestive of right fallopian tube fimbrial block & left fallopian tube cornual blockage. Her USG scan suggestive of bilateral polycystic ovary & a tiny echogenic polyp of size 3.7x2.3mm in mid part of endometrial cavity. Her prolactin level was found elevated. Interventions: Treatment given was Beejasamskara, Uttarbasti with Apamarga kshara tail & Shudah bala tail along with oral medication. Outcome: She conceived after taking 6 months of treatment. She was given proper antenatal care along with garbhsamskara. She delivered a healthy female baby of weight 3.03kg on 7th Jan 2022. Conclusion: This case study shows the potential of Beejasamskara, Uttarbasti in the management of infertility and the role of Garbhsamskara during the antenatal period.

OBJECTIVES To estimate the impacts of 2 interventions, early stimulation (ES) for children aged METHODS In Odisha, India, 192 villages were randomly assigned to ES or to no ES. Within each village, about 8 mothers with children initially aged 7 to 16 months were enrolled, receiving ES or no ES accordingly (n = 1449). Subsequently, when children were aged ∼3 years, the villages were rerandomized to either EP at Anganwadi centers or no EP. This yielded 4 groups: (1) ES and EP, (2) only ES, (3) only EP, and (4) no intervention. Trained Anganwadi workers ran the EP. Primary outcomes, measured at baseline and follow-up after ∼1 year, were children’s IQ (summarizing cognition, language, and executive functioning) and school readiness (SR). Secondary outcomes were home environments, caregivers’ child-development knowledge. and preschool quality. RESULTS Fifteen months after ES ended, onlyES had a sustained benefit on IQ (0.18 SD, P CONCLUSIONS Both ES and EP increased IQ and SR. Only ES impacts were sustained for 15 months. Only EP resulted in considerable catch-up for children who did not receive only ES. The absence of significant complementarities should be investigated further because of its profound policy implications.

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Supplementary Material-1. Heatmap shows all the known ligand-receptor interactions between different cell types identified by CellPhoneDB in the OvD5-SS2 dataset.

SupplementaryMethods.docx from Oncostatin M Receptor–Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth

Although patients with advanced ovarian cancer may respond initially to treatment, disease relapse is common, and nearly 50% of patients do not survive beyond five years, indicating an urgent need for improved therapies. To identify new therapeutic targets, we performed single-cell and nuclear RNA-seq data set analyses on 17 human ovarian cancer specimens, revealing the oncostatin M receptor (OSMR) as highly expressed in ovarian cancer cells. Conversely, oncostatin M (OSM), the ligand of OSMR, was highly expressed by tumor-associated macrophages and promoted proliferation and metastasis in cancer cells. Ovarian cancer cell lines and additional patient samples also exhibited elevated levels of OSMR when compared with other cell types in the tumor microenvironment or to normal ovarian tissue samples. OSMR was found to be important for ovarian cancer cell proliferation and migration. Binding of OSM to OSMR caused OSMR–IL6ST dimerization, which is required to produce oncogenic signaling cues for prolonged STAT3 activation. Human monoclonal antibody clones B14 and B21 directed to the extracellular domain of OSMR abrogated OSM-induced OSMR–IL6ST heterodimerization, promoted the internalization and degradation of OSMR, and effectively blocked OSMR-mediated signaling in vitro. Importantly, these antibody clones inhibited the growth of ovarian cancer cells in vitro and in vivo by suppressing oncogenic signaling through OSMR and STAT3 activation. Collectively, this study provides a proof of principle that anti-OSMR antibody can mediate disruption of OSM-induced OSMR–IL6ST dimerization and oncogenic signaling, thus documenting the preclinical therapeutic efficacy of human OSMR antagonist antibodies for immunotherapy in ovarian cancer.Significance:This study uncovers a role for OSMR in promoting ovarian cancer cell proliferation and metastasis by activating STAT3 signaling and demonstrates the preclinical efficacy of antibody-based OSMR targeting for ovarian cancer treatment.

Introduction - Rifampin, isoniazid, pyrazinamide, and ethambutol are antitubercular drugs that have been licenced by the FDA for the treatment of Mycobacterium tuberculosis infections. Antitubercular medicines are drugs that are used to treat tuberculosis. The term "anthelmintic" refers to a medicine used to treat parasitic worm infestations in animals. This comprises both flat and round worms, such as flukes (trematodes) and tapeworms (cestodes) (nematodes). Aim of this study - The primary aim of this research is to develop and validate simple, fast, reliable, robustness and ruggedness analytical procedures for anthelmintics (ALB) and antitubercular (ETH) medicines. Material and Methods - Two CT reagents, iodine and picric acid, were used to produce two simple and somewhat sensitive Albendazole (ALB) and Ethionamide (ETN) techniques. The CT complex with the placebo blank had almost the same absorbance as the reagent blank, indicating that there was no interference by using Systronics model 166 digital spectrophotometer tools. Organic solvents were employed to dissolve all of the chemicals, which were of analytical reagent grade.

The State of Jammu and Kashmir went through extraordinary and potentially notable changes on August 5, 2019, while the President was in power. These changes drastically impacted the State's constitutional relationship with the Union of India. As a rule, these noteworthy improvements incorporate the compelling cancellation “of Article 370 of the Indian Constitution and the division of the State of Jammu and Kashmir into the Union Domains of Jammu and Kashmir and Ladakh, ending Jammu and Kashmir's unique status under the Indian Constitution. This article initially portrays the legitimate activities used” to achieve these alterations prior to analyzing their constitutionality. The paper likewise gives a lawful criterion to such decisions that the President and Parliament might make when President's rule is set up, and makes the contention that, when held up to this norm, canceling Article 370 and parting the State of Jammu and Kashmir are unlawful. The examination additionally looks at past Supreme Court judgements on executive and legislative policy issues to decide the extent of judicial review in the ongoing case.

Target of vision 2020- right to sight is to control blindness. Blindness in children affects their psychological and social growth. Various research were done on community and in blind school to know about the prevalence and causes of blindness in children. Total five- community based studies were done for knowing about the prevalence of blindness that also includes two refractive error studies for the children below 16 years of age in India. Result of data collected from blind school showed that blindness in children shifted from corneal causes to whole globe abnormalities. Blindness in children has different impact in different region based upon the socioeconomic development of that region, primary health care centre present in that region and also the eye care services provided to the people. The strategies to control blindness should be region specific. Solution has to be drafted based on regional challenges, in such a way that it helps to cure the blindness and also help to reduce the chances of blindness in future. Prevention strategies is targeted towards proper and timely immunization, control of Vit A deficiency by providing healthy and balanced diet and to educate people about the outcome of blindness and also providing tertiary level care to treat the causes. No available data is present to know about the causes and incidence of blindness in children. Rehabilitation programme done on community level help to identify the incidence and causes of blindness in children present in India. In this article we have discussed about childhood blindness, prevalence of childhood blindness, causes of childhood blindness, prevention of childhood blindness, control of childhood blindness, programmes running for childhood blindness. Refractive error such as myopia leads to blindness in children. School going children are at increase risk for developing blindness due to refractive error that is not corrected. Control of blindness in children is very important because a child suffer more years from blindness than adults. Around 1.4 million are affected by childhood blindness globally. Per year approx 500000 children are affected and became blind. The cause that is most common and in fact single for childhood blindness worldwide is vit A deficiency. By the year 2020, WHO has took the initiative to eliminate blindness. Some of the factors that can help are good nutrition to child, taking proper care of mother and child, proper immunization of mother and child, health education etc.

Out of all the cranial nerves “Trigeminal Nerve” is the fifth cranial nerve. Trigeminal nerve possesses both the components i.e. mixed components as well as sensitive components that’s why trigeminal nerve is known as a mixed nerve. The sensitive component of the trigeminal nerve takes up the sensation from most of the part of the face and the mucous membrane to the central nervous system and that’s why it is responsible for the disease which is known as trigeminal neuralgia. The characteristic feature of the trigeminal neuralgia is the sudden onset of pain which is sharp and lacerating, and that may last from few of the seconds to few minutes. Trigeminal neuralgia more frequently affects the female as compared to the male.

The ongoing COVID-19 pandemic has seriously impacted countries across the globe. The pandemic has created a completely new teaching-learning environment of interaction for early childhood educators. In many countries, face-to-face teaching has been replaced by remote teaching, while in others, there have been intermittent lockdowns and limited interruptions to regular teaching norms. Given the play-based nature of preschool teaching-learning activities in most countries, educators are required to reimagine the sociocultural relationships to their pedagogical practices in their everyday teaching-learning contexts. This paper sheds light on educators' experiences and the dramatic shift in their indoor-outdoor teaching-learning environment due to the evolving health measures. The study draws on notions of teachers' identities and Vygotsky's cultural-historical concept of social situation of development (Vygotsky, 1994) to capture the new forms of relationships that early childhood educators experienced with their pedagogical environments across different countries during the pandemic. Data were collected from preschool teachers across five countries-Australia, Bangladesh, Norway, Singapore and India using online surveys which included open- and close-ended questions. Findings reveal the on-ground realities and teachers' adaptations to new pedagogies emerging across the five countries. The new digital environments provided an equally new dimension for change. These changes were seen in interactions, relationships within the everyday pedagogical contexts, as well as the shifting physical and social environment of early years educators.La pandémie actuelle de COVID-19 a gravement touché les pays du monde entier. La pandémie a créé un tout nouvel environnement d'interaction enseignement-apprentissage pour les éducateurs de la petite enfance. Dans de nombreux pays, l'enseignement en face à face a été remplacé par l'enseignement à distance, tandis que dans d'autres, il y a eu des blocages intermittents et des interruptions limitées des normes d'enseignement régulières. Étant donné la nature ludique des activités d'enseignement-apprentissage préscolaires dans la plupart des pays, les éducateurs sont tenus de réimaginer les relations socioculturelles avec leurs pratiques pédagogiques dans leurs contextes d'enseignement-apprentissage quotidiens. Cet article met en lumière les expériences des éducateurs et le changement radical de leur environnement d'enseignement-apprentissage intérieur-extérieur en raison de l'évolution des mesures de santé. L'étude s'appuie sur les notions d'identité des enseignants et le concept culturel et historique de Vygotsky de situation sociale de développement (Vygotsky, 1994) pour saisir les nouvelles formes de relations que les éducateurs de la petite enfance ont vécues avec leurs environnements pédagogiques dans différents pays pendant la pandémie. Les données ont été recueillies auprès d'enseignants du préscolaire dans cinq pays—Australie, Bangladesh, Norvège, Singapour et Inde à l'aide d'enquêtes en ligne comprenant des questions ouvertes et fermées. Les résultats révèlent les réalités sur le terrain et les adaptations des enseignants aux nouvelles pédagogies émergentes dans les cinq pays. Les nouveaux environnements numériques ont fourni une dimension tout aussi nouvelle pour le changement. Ces changements ont été observés dans les interactions, les relations au sein des contextes pédagogiques quotidiens, ainsi que dans l'environnement physique et social changeant des éducateurs de la petite enfance.La pandemia de COVID-19 en curso ha afectado gravemente a países de todo el mundo. La pandemia ha creado un entorno de interacción de enseñanza-aprendizaje completamente nuevo para los educadores de la primera infancia. En muchos países, la enseñanza presencial ha sido reemplazada por la enseñanza a distancia, mientras que en otros, ha habido bloqueos intermitentes e interrupciones limitadas de las normas de enseñanza regulares. Dada la naturaleza basada en el juego de las actividades de enseñanza-aprendizaje preescolar en la mayoría de los países, los educadores deben reinventar las relaciones socioculturales con sus prácticas pedagógicas en sus contextos cotidianos de enseñanza-aprendizaje. Este documento arroja luz sobre las experiencias de los educadores y el cambio dramático en su entorno de enseñanza-aprendizaje interior y exterior debido a la evolución de las medidas de salud. El estudio se basa en las nociones de las identidades de los maestros y el concepto histórico-cultural de Vygotsky sobre la situación social del desarrollo (Vygotsky, 1994) para capturar las nuevas formas de relaciones que los educadores de la primera infancia experimentaron con sus entornos pedagógicos en diferentes países durante la pandemia. Se recopilaron datos de maestros de preescolar en cinco países: Australia, Bangladesh, Noruega, Singapur e India mediante encuestas en línea que incluían preguntas abiertas y cerradas. Los hallazgos revelan las realidades sobre el terreno y las adaptaciones de los profesores a las nuevas pedagogías que surgen en los cinco países. Los nuevos entornos digitales proporcionaron una dimensión igualmente nueva para el cambio. Estos cambios se observaron en las interacciones, las relaciones dentro de los contextos pedagógicos cotidianos, así como en el entorno físico y social cambiante de los educadores de la primera infancia.

While trade opening is generally welfare enhancing, it requires a reallocation of capital and labor across sectors and firms. The empirical evidence on how this reallocation works is still relative...

Some differential implications of classical Marx–Strohhacker theorem are extended for multivalent functions. These results are also generalized for functions with fixed second coefficient by using the theory of first order differential subordination which in turn, corrects the results of Selvaraj and Stelin (Int J Math Anal 9(18): 883–895, 2015).

The paper deals with a dual wide band micro-strip line fed compact antenna consisting of wide circular slot. The proposed antenna is designed on FR-4 dielectric material having εr = 4.3. The antenna is fed by 50 Ω microstrip line and the optimized volumetric dimension of the proposed antenna is 36×36×1.6 mm3. A wide circular slot is cut from the ground plane resulting in dual nature of antenna with the wide band of 1.23 GHz and 2.4 GHz at 5.8 GHz and 8.4 GHz of frequency which comes under the C- and X-band of electromagnetic spectrum. The design is not only procuring wide band but also a remarkable gain at both operating frequencies. At last, to validate the proposed work, the design is fabricated and further tested using vector network analyzer. The simulated and measured results are in good agreement.

Multiple primary cancers are gradually becoming a regular condition and frequently result in many diagnostic and therapeutic difficulties. In our case report we present a 68-year female with breast lump who was incidentally diagnosed with chronic myeloid leukemia. The fine needle aspiration biopsy (FNAC) of the breast lump lead to the diagnosis of Invasive ductal carcinoma.

Breast cancer (BC) is one of the most diagnosed and worldwide malignancies in females with an estimated 1,300,000 new cases and 465,000 deaths annually. Therefore, early diagnosis and effective treatments of BC are urgently needed in the struggle against this disease. Molecular markers research has gained huge momentum in BC management. Very few molecular markers are in clinical use for BC management. However, owing to BC heterogeneity, more molecular markers are required for better diagnosis and treatment. Humoral immune response defines the generation of autoantibodies (AAbs) in blood against tumor-associated antigens (TAAs). Such AAbs have been showing great promises for biomarker development for cancer detection. Therefore, these candidate AAbs might be useful for developing blood-based detection assays along with other existing diagnostic tools for BC patients. Besides that, AAbs can also assist in the identification of novel TAAs that can further enhance the utility of immuno-proteomics for biomarkers development and targeted therapy. In this scenario, proteomics tools are being extensively utilized to identify novel TAAs.

Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of primary gastrointestinal lymphomas. It is a clinically heterogenous disease as most patients respond well to therapy, however a significant proportion of these patients become refractory or eventually relapse. Different prognostic factors for response and survival have been described for DLBCL. Immunophenotypic algorithms with small panels of biomarkers have been developed to translate the robust information from molecular studies into a routine clinical. platform. One of these biomarkers is MUM-1 which is used as a marker for classification of diffuse large B cell lymphoma into ABC type and its expression is associated with poorer overall survival as stated by various studies. We aim to study the expression pattern of MUM-1 IHC in primary gastrointestinal diffuse large B cell lymphomas and its role in prognosis and survival outcome. Materials and Methods: It was a five-year retrospective study where 40 cases of primary gastrointestinal DLBCL were identified, and MUM-1 IHC was done in 29 cases. Follow up and subsequent survival analysis was done. Results: MUM-1 was positive in 7 (24%) and negative in 22 (76%) cases of primary gastrointestinal DLBCL. The overall survival of patients with DLBCL with MUM-1 [removed]42.9%) was shorter than those without MUM-1 [removed]72.7%). This suggested that MUM-1 expression in cases with DLBCL is associated with poorer prognosis. Conclusion: Multicentre large studies are warranted to study the role of MUM-1 IHC in prognosis of primary gastrointestinal DLBCL. Keywords: Activated B cell type, Gastrointestinal lymphoma, Gene expression profiling, Germinal centre B-cell, Immunohistochemistry.

In this paper, we report some interesting results on permutations on $${\mathbb {Z}}_{n}$$ , the ring of integers modulo n, having full differential uniformity. By full differential uniformity of a permutation f on $${\mathbb {Z}}_{n}$$ , we mean that the cardinality of the set $$\{x\in {\mathbb {Z}}_{n}: f(x+a)-f(x)=b\}$$ is exactly n for some $$a,b\in {\mathbb {Z}}_{n}\setminus \{0\}$$ . We give a sufficient condition for an arbitrary map on $${\mathbb {Z}}_{n}$$ to have full differential uniformity. A necessary and sufficient condition for a permutation to have full differential uniformity over the ring of integers modulo n is also given. Further, we propose an upper bound and two lower bounds on permutations with full differential uniformity on $${\mathbb {Z}}_{n}$$ . We prove that these bounds are non-trivial bounds and give the exact number of permutations with full differential uniformity for a certain class of moduli.

We developed a multiscale model for simulating aggregation of multiple, free-flowing platelets in low-intermediate shear viscous flow, in which aggregation is mediated by the interaction of α(IIb)β(3) receptors on the platelets membrane and fibrinogen (Fg). This multiscale model uses coarse grained molecular dynamics (CGMD) for platelets at the microscales, and dissipative particle dynamics (DPD) for the shear flow at the macroscales, employing our hybrid aggregation force field for modeling molecular level receptor ligand bonds. We define an aggregation tensor and use it to quantify the molecular level contact characteristics between platelets in an aggregate. We perform numerical studies under different flow conditions for platelet doublets and triplets and evaluate the contact area, detaching force, and minimum distance between different pairs of platelets in an aggregate. We also present the dynamics of applied stress and velocity magnitude distributions on the platelet membrane during aggregation and quantify the increase in stress in the contact region under different flow conditions. Integrating the knowledge from our previously validated models, together with new aggregation scenarios, our model can dynamically quantify aggregation characteristics and map stress and velocity distribution on the platelet membrane which are difficult to measure in vitro, thus providing an insight into mechanotransduction bond formation response of platelets to flow induced shear stresses. This modeling framework, together with the tensor method for quantifying inter-platelet contact, can be extended to simulate and analyze larger aggregates and their adhesive properties.

Background: Communication between cancer cells and surrounding cells in the tumor microenvironment (TME) is critical for tumor metastasis. There has been an increasing focus on how tumor-derived extracellular vesicles (EVs) contribute to the complex intracellular communications within the TME. More recent characterizations in both mice and humans have demonstrated that expression of the immune checkpoint molecule, programmed death ligand-1 (PD-L1) on EVs contributes to systemic immunosuppression, higher overall tumor burdens, and decreased survival of a variety of cancer types. In ovarian carcinoma, macrophages are reprogrammed toward pro-tumorigenic phenotypes, including the release of anti-inflammatory cytokines and expression of immunosuppressive molecules such as arginase-1 and PD-L1. However, a detailed mechanism that explains how tumor-derived EVs induce immunosuppressive phenotype in macrophages is necessary to develop novel immunotherapy strategies for advanced ovarian cancer treatment. The present study aimed to examine the effect of EVs derived from ovarian cancer cells on macrophage functions. Methods: We isolated murine peritoneal macrophages from naïve C57BL/6 female mice and co-cultured the macrophages with EVs derived from ovarian cancer (ID8-Trp53-/-Brca2-/-) cell lines. The expression of PD-L1, CD206, interleukin-6 (IL-6), and other inflammatory cytokines on EVs treated macrophages was evaluated using flow cytometry and a cytokine array kit. Further, we created Rab27aKO ID8 cell lines to generate ovarian cancer in vivo mouse models for studying the effect of exogenous EVs on the immunosuppressive ability of macrophages and tumor progression. Results: Our results indicate that EVs uptake efficiency of macrophages is higher than fibroblast, endothelial, and mesothelial cells. We found that tumor-derived EVs can significantly upregulate the expressions of PD-L1, CD206, and IL-6 on macrophages to support tumor growth. Treatment of macrophages with EVs also decreased their phagocytic ability. In addition, our data show that in the Rab27aKO ovarian cancer in vivo mouse model, intravenous injection of tumor-derived EVs increased the tumor burden, metastasis, and ascites accumulation as compared to PBS control. EVs treatment increased the infiltration of tumor-associated macrophages (TAM) in ascites. We also found increased expression of PD-L1 and CD206 on TAM isolated from ascites. Conclusion: We uncover a tumor-promoting role of ovarian cancer-derived EVs on reprogramming TAM towards pro-tumor phenotype. Our data suggest that tumor-derived EVs contribute to the formation of an immunosuppressive microenvironment to promote ovarian cancer growth. Citation Format: Sonam Mittal, Ishaque Pulikkal Kadamberi, Prachi Gupta, Sudhir Kumar, Jasmine George, Anjali Geethadevi, Pradeep Chaluvally-Raghavan, Sunila Pradeep. Tumor-derived extracellular vesicles induce macrophages immunosuppressive polarization to promote ovarian cancer progression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2321.

The purpose of this work is to investigate three antenna designs using the main element that provides radiation pattern with diminish side lobes and high gain of interest for the fifth generation. Antenna designs comprises: (1) fully filled 8 × 8 planar array (2) optimized thinned planar array and (3) optimized tapered planar array. The main motive is to inactive a few number of elements of a fully filled 8 × 8 array while keeping the gain and return loss undisturbed ensuring the high reduction in sidelobe levels. GA (Genetic Algorithm) is tested to estimate the optimized amalgamation of inactive and active elements corresponding to reduce sidelobe levels. Optimization techniques such as the Thinning and Tapering of the planar array are considered in this study. The performances of all three types of optimized planar antenna arrays which are designed on RT/Duroid 5880 dielectric are investigated through a finite element study using CST MW Studio ver.2018 software operating at the desired 28 GHz frequency. By comparing with a fully filled planar array of equal size, the simulation results unveil that optimized thinned and tapered planar arrays show better performance in terms of future generation aspects.

Introduction: Head and neck lesions are very common in day to day practice. These diseases range from common cold to the uncommon, malignant neoplasms. These lesions are responsible for very high morbidity and mortality. Factors known to contribute to the risk of developing head and neck cancer are smokeless tobacco (Pan masala, soda), alcohol, HPV viral infections, etc. Smokeless tobacco is commonly used in Northern part of India, especially in Uttar Pradesh. Aim: To evaluate the diagnosis, frequency and histopathological subtypes of head and neck lesions and their distribution in different age groups and sex in Western Uttar Pradesh. Settings and Design: A retrospective study of 3 years from March 2014 to February 2017 was conducted and the data were collected from the archives of the department. The data were analyzed using SPSS version 15.0. Materials and Methods: All the biopsies from the head and neck region, which were submitted for histopathology in the Post Graduate department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, were reviewed and analyzed for their demographic profile, age, gender, site and diagnosis. The lesions were then categorized accordingly as inflammatory, benign and malignant. Results: All the lesions of head and neck region, diagnosed on histopathology were included in the present study. A total of three hundred twenty one biopsies were studied, including 212 (66%) males and 109 (34%) females (M: F=1.9:1). 197 (61%) of the cases were benign, followed by 69 (22%) malignant and 55 (17%) inflammatory lesions. The maximum numbers of malignant cases were in the age group of 41 to 50 years with Squamous cell carcinoma as the most common histopathological type. The most common site of malignant lesions was the oral cavity. The maximum benign lesions were in the 11-20 years age group. Conclusions: The present study helped us in assessing the frequency as well as the different histopathological types of head and neck lesio

We develop a statistical method to learn a molecular Hamiltonian matrix from a time-series of electron density matrices. We extend our previous method to larger molecular systems by incorporating physical properties to reduce dimensionality, while also exploiting regularization techniques like ridge regression for addressing multicollinearity. With the learned Hamiltonian we can solve the Time-Dependent Hartree-Fock (TDHF) equation to propagate the electron density in time, and predict its dynamics for field-free and field-on scenarios. We observe close quantitative agreement between the predicted dynamics and ground truth for both field-off trajectories similar to the training data, and field-on trajectories outside of the training data.