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34 results on '"Pozo-Laderas, Juan Carlos"'

1. Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort

Author

Ceccato, Adrian, Forne, Carles, Bos, Lieuwe D., Camprubí-Rimblas, Marta, Areny-Balagueró, Aina, Campaña-Duel, Elena, Quero, Sara, Diaz, Emili, Roca, Oriol, De Gonzalo-Calvo, David, Fernández-Barat, Laia, Motos, Anna, Ferrer, Ricard, Riera, Jordi, Lorente, Jose A., Peñuelas, Oscar, Menendez, Rosario, Amaya-Villar, Rosario, Añón, José M., Balan-Mariño, Ana, Barberà, Carme, Barberán, José, Blandino-Ortiz, Aaron, Boado, Maria Victoria, Bustamante-Munguira, Elena, Caballero, Jesús, Carbajales, Cristina, Carbonell, Nieves, Catalán-González, Mercedes, Franco, Nieves, Galbán, Cristóbal, Gumucio-Sanguino, Víctor D., de la Torre, Maria del Carmen, Estella, Ángel, Gallego, Elena, García-Garmendia, José Luis, Garnacho-Montero, José, Gómez, José M., Huerta, Arturo, Jorge-García, Ruth Noemí, Loza-Vázquez, Ana, Marin-Corral, Judith, Martínez de la Gándara, Amalia, Martin-Delgado, María Cruz, Martínez-Varela, Ignacio, Messa, Juan Lopez, Muñiz-Albaiceta, Guillermo, Nieto, María Teresa, Novo, Mariana Andrea, Peñasco, Yhivian, Pozo-Laderas, Juan Carlos, Pérez-García, Felipe, Ricart, Pilar, Roche-Campo, Ferran, Rodríguez, Alejandro, Sagredo, Victor, Sánchez-Miralles, Angel, Sancho-Chinesta, Susana, Socias, Lorenzo, Solé-Violan, Jordi, Suarez-Sipmann, Fernando, Tamayo-Lomas, Luis, Trenado, José, Úbeda, Alejandro, Valdivia, Luis Jorge, Vidal, Pablo, Bermejo, Jesus, Gonzalez, Jesica, Barbe, Ferran, Calfee, Carolyn S., Artigas, Antonio, and Torres, Antoni

Published
2024
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2. Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients

Author

Galli, Flavia, Bindo, Francesco, Motos, Anna, Fernández-Barat, Laia, Barbeta, Enric, Gabarrús, Albert, Ceccato, Adrián, Bermejo-Martin, Jesús F., Ferrer, Ricard, Riera, Jordi, Peñuelas, Oscar, Lorente, José Ángel, de Gonzalo-Calvo, David, Menéndez, Rosario, Gonzalez, Jessica, Misuraca, Sofia, Palomeque, Andrea, Amaya-Villar, Rosario, Añón, José Manuel, Balan Mariño, Ana, Barberà, Carme, Barberán, José, Blandino Ortiz, Aaron, Bustamante-Munguira, Elena, Caballero, Jesús, Cantón-Bulnes, María Luisa, Carbajales Pérez, Cristina, Carbonell, Nieves, Catalán-González, Mercedes, de Frutos, Raul, Franco, Nieves, Galbán, Cristóbal, Lopez Lago, Ana, Gumucio-Sanguino, Víctor D., de la Torre, Maria del Carmen, Díaz, Emilio, Estella, Ángel, Gallego Curto, Elena, García-Garmendia, José Luis, Gómez, José Manuel, Huerta, Arturo, Jorge García, Ruth Noemí, Loza-Vázquez, Ana, Marin-Corral, Judith, Martin Delgado, María Cruz, Martínez de la Gándara, Amalia, Martínez Varela, Ignacio, Lopez Messa, Juan, M. Albaiceta, Guillermo, Nieto, María Teresa, Novo, Mariana Andrea, Peñasco, Yhivian, Pérez-García, Felipe, Pozo-Laderas, Juan Carlos, Ricart, Pilar, Sagredo, Victor, Sánchez-Miralles, Angel, Sancho Chinesta, Susana, Roche-Campo, Ferran, Socias, Lorenzo, Solé-Violan, Jordi, Suarez-Sipmann, Fernando, Tamayo Lomas, Luis, Trenado, José, Úbeda, Alejandro, Valdivia, Luis Jorge, Vidal, Pablo, Boado, Maria Victoria, Rodríguez, Alejandro, Antonelli, Massimo, Blasi, Francesco, Barbé, Ferran, and Torres, Antoni

Published
2023
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3. Key Factors Associated With Pulmonary Sequelae in the Follow-Up of Critically Ill COVID-19 Patients

Author

Cabello, María Aguilar, Alcaraz-Serrano, Victoria, Aldecoa, Cesar, Alegre, Cynthia, Calderón, Ángela Algaba, Álvarez, Sergio, Ruiz, Antonio Álvarez, Andrea, Ruth, Aparicio, Maria de Alba, Arrieta, Marta, Ayestarán, J. Ignacio, Badia, Joan Ramon, Badía, Mariona, Pravia, Orville Báez, Mariño, Ana Balan, Balsera, Begoña, Barbena, Laura, Barbeta, Enric, Bardi, Tommaso, Segade, Patricia Barral, Barroso, Marta, García, José Ángel Berezo, Bermejo, Jesus, Bigas, Judit, Blancas, Rafael, Cortés, María Luisa Blasco, Saera, María Bodi, Bofill, Neus, Vieiro, María Teresa Bouza, Bueno, Leticia, Bustamante-Munguira, Juan, Martínez, Cecilia del Busto, Hermoso, David Campi, Fernández, Sandra Campos, Cano, Iosune, Canseco, Joan, Fernández, Pablo Cardinal, García, Laura Carrión, Carvalho, Sulamita, Castellà, Manuel, Castellví, Andrea, Castro, Pedro, Centelles-Serrano, María José, Ávila, Ramon Cicuendez, Cillóniz, Catia, Clar, Luisa, Climent, Cristina, Codina, Jordi, Conde, Pamela, Contreras, Sofía, Parra, Raul de Frutos, Sánchez, Raul de Pablo, Mendoza, Diego De, Díaz, Yolanda, Vilas, María Digna Rivas, Moreno, Cristina Dólera, Dot, Irene, Giraudo, Pedro Enríquez, Arijón, Inés Esmorís, Monjo, Teresa Farre, Fernández, Javier, Ferrando, Carlos, Figueras, Albert, Espina, Lorena Forcelledo, Franquesa, Enric, Furro, Àngels, Gabarrus, Albert, Galbán, Cristóbal, García, Felipe, García, Beatriz, Prieto, Emilio García, Redruello, Carlos García, Sagastume, Amaia García, Castillo, Maria Luisa Gascón, Gomà, Gemma, Casal, Vanesa Gómez, Gómez, Silvia, Gonzalez, Carmen Gómez, Gordo, Federico, Gracia, Maria Pilar, Fernández, María José Gutierrez, Herraiz, Alba, Herrán-Monge, Rubén, Ibarz, Mercedes, Iglesias, Silvia, Janer, Maria Teresa, Jiménez, Gabriel, Díaz, Mar Juan, Kiarostami, Karsa, Álvarez, Juan I. Lazo, León, Miguel, López-Gavín, Alexandre, Guerrero, Desiree Macias, Herrera, Nuria Mamolar, Mendiluce, Rafael Mañez, Mantellini, Cecilia L., Naya, Gregorio Marco, Barcos, Iris Marco, Marcos, Pilar, Peis, Enrique Marmol, Cuadrado, Marta Martín, Delgado, María Cruz Martin, Vicente, Paula Martín, Martínez, María, Fernández, Carmen Eulalia Martínez, Juan, Maria Dolores Martínez, Palacios, Basilisa Martínez, Jimenez, Juan Fernando Masa, Masclans, Joan Ramon, Maseda, Emilio, Fernández, Eva María Menor, Banderas, Priscila Metora, Minguez, Olga, Miralbés, Mar, Monclou, Josman, Montejo-González, Juan Carlos, Montserrat, Neus, Aznar, María Mora, Morales, Dulce, Cano, Sara Guadalupe Moreno, Rodríguez, David Mosquera, Muñoz-Bermúdez, Rosana, Nicolás, José María, Bou, Ramon Nogue, Salinas, Rafaela Nogueras, Ocón, Marta, Ortega, Ana, Ossa, Sergio, Pagliarani, Pablo, Parrilla, Francisco, Pedregosa-Díaz, José, Bastida, Leire Pérez, Pérez, Purificación, Pérez-García, Felipe, Planelles, Gloria Pérez, Rubio, Eva Pérez, Laguna, David Pestaña, Prados, Javier, Pujol, Andrés, Coll, Núria Ramon, Sanchez-Giron, Gloria Renedo, Roche-Campo, Ferran, Rodriguez, Laura, Castro, Felipe Rodríguez de, Rodríguez, Silvia, Ruiz, Covadonga Rodríguez, Rubio, Jorge, López, Alberto Rubio, Ruiz-García, Ángela Leonor, Miralles, Miriam Ruiz, Murúa, Pablo Ryan, Paz, Eva Saborido, Degracia, Ana Salazar, Sanchez, Miguel, Sánchez, Ana, Chinesta, Susana Sancho, Santacoloma, Bitor, Sariñena, Maria Teresa, Pensado, Marta Segura, Serra, Lidia, Serra-Fortuny, Mireia, Lázaro, Ainhoa Serrano, Servià, Lluís, Soliva, Laura, Speziale, Carla, Tormos, Adrián, Torres, Mateu, Tranque-Liberal, Celia, Trefler, Sandra, Trujillano, Javier, Vaca, Rafaela, Val, Estela, Ruiz, Luis Valdivia, Vallverdú, Montserrat, Martin-Montalvo, Maria Van der Hofstadt, Adrio, Sabela Vara, Vázquez, Nil, Vengoechea, Javier, Vilà-Vilardel, Clara, Vilanova, Judit, Warrington, Tatiana Villada, Yang, Hua, Yang, Minlan, Zapatero, Ana, González, Jessica, de Batlle, Jordi, Benítez, Iván D., Torres, Gerard, Santisteve, Sally, Targa, Adriano D.S., Gort-Paniello, Clara, Moncusí-Moix, Anna, Aguilà, Maria, Seck, Fatty, Ceccato, Adrián, Ferrer, Ricard, Motos, Anna, Riera, Jordi, Fernández, Laia, Menéndez, Rosario, Lorente, José Ángel, Peñuelas, Oscar, Garcia-Gasulla, Dario, Peñasco, Yhivian, Ricart, Pilar, Abril Palomares, Elena, Aguilera, Luciano, Rodríguez, Alejandro, Boado Varela, Maria Victoria, Beteré, Belén, Pozo-Laderas, Juan Carlos, Solé-Violan, Jordi, Salvador-Adell, Inmaculada, Novo, Mariana Andrea, Barberán, José, Amaya Villar, Rosario, Garnacho-Montero, José, Gómez, José M., Blandino Ortiz, Aaron, Tamayo Lomas, Luis, Úbeda, Alejandro, Catalán-González, Mercedes, Sánchez-Miralles, Angel, Martínez Varela, Ignacio, Jorge García, Ruth Noemí, Franco, Nieves, Gumucio-Sanguino, Víctor D., Bustamante-Munguira, Elena, Valdivia, Luis Jorge, Caballero, Jesús, Gallego, Elena, Rodríguez, Covadonga, Castellanos-Ortega, Álvaro, Trenado, Josep, Marin-Corral, Judith, Albaiceta, Guillermo M., de la Torre, Maria del Carmen, Loza-Vázquez, Ana, Vidal, Pablo, Añón, Jose M., Carbajales Pérez, Cristina, Sagredo, Victor, Carbonell, Nieves, Socias, Lorenzo, Barberà, Carme, Estella, Angel, Diaz, Emili, de Gonzalo-Calvo, David, Torres, Antoni, and Barbé, Ferran

Published
2023
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4. Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID study

Author

Torres, Antoni, Motos, Ana, Cillóniz, Catia, Ceccato, Adrián, Fernández-Barat, Laia, Gabarrús, Albert, Bermejo-Martin, Jesús, Ferrer, Ricard, Riera, Jordi, Pérez-Arnal, Raquel, García-Gasulla, Dario, Peñuelas, Oscar, Lorente, José Ángel, de Gonzalo-Calvo, David, Almansa, Raquel, Menéndez, Rosario, Palomeque, Andrea, Villar, Rosario Amaya, Añón, José M., Balan Mariño, Ana, Barberà, Carme, Barberán, José, Blandino Ortiz, Aaron, Boado, Maria Victoria, Bustamante-Munguira, Elena, Caballero, Jesús, Cantón-Bulnes, María Luisa, Carbajales Pérez, Cristina, Carbonell, Nieves, Catalán-González, Mercedes, de Frutos, Raul, Franco, Nieves, Galbán, Cristóbal, Gumucio-Sanguino, Víctor D., de la Torre, Maria del Carmen, Díaz, Emili, Estella, Ángel, Gallego, Elena, García Garmendia, José Luis, Gómez, José M., Huerta, Arturo, García, Ruth Noemí Jorge, Loza-Vázquez, Ana, Marin-Corral, Judith, Martin Delgado, María Cruz, Martínez de la Gándara, Amalia, Martínez Varela, Ignacio, López Messa, Juan, Albaiceta, Guillermo M., Nieto, Maite, Novo, Mariana Andrea, Peñasco, Yhivian, Pérez-García, Felipe, Pozo-Laderas, Juan Carlos, Ricart, Pilar, Sagredo, Victor, Sánchez-Miralles, Angel, Sancho Chinesta, Susana, Serra-Fortuny, Mireia, Socias, Lorenzo, Solé-Violan, Jordi, Suarez-Sipmann, Fernando, Tamayo Lomas, Luis, Trenado, José, Úbeda, Alejandro, Valdivia, Luis Jorge, Vidal, Pablo, and Barbé, Ferran

Published
2022
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5. Methodology of a Large Multicenter Observational Study of Patients with COVID-19 in Spanish Intensive Care Units

Author

Torres, Antoni, Motos, Anna, Ceccato, Adrián, Bermejo-Martin, Jesús, de Gonzalo-Calvo, David, Pérez, Raquel, Barroso, Marta, Pascual, Ion Zubizarreta, Gonzalez, Jessica, Fernández-Barat, Laia, Ferrer, Ricard, Riera, Jordi, García-Gasulla, Dario, Peñuelas, Oscar, Lorente, José Ángel, Almansa, Raquel, Menéndez, Rosario, Kiarostami, Kasra, Canseco, Joan, Villar, Rosario Amaya, Añón, José M., Mariño, Ana Balan, Barberà, Carme, Barberán, José, Ortiz, Aaron Blandino, Boado, Maria Victoria, Bustamante-Munguira, Elena, Caballero, Jesús, Cantón-Bulnes, María Luisa, Pérez, Cristina Carbajales, Carbonell, Nieves, Catalán-González, Mercedes, de Frutos, Raúl, Franco, Nieves, Galbán, Cristóbal, Gumucio-Sanguino, Víctor D., Torre, María del Carmen de la, Díaz, Emili, Estella, Ángel, Gallego, Elena, Garmendia, José Luis García, Gómez, José M., Huerta, Arturo, García, Ruth Noemí Jorge, Loza-Vázquez, Ana, Marin-Corral, Judith, Delgado, María Cruz Martin, Gándara, Amalia Martínez de la, Varela, Ignacio Martínez, Messa, Juan López, Albaiceta, Guillermo M., Nieto, Maite, Novo, Mariana Andrea, Peñasco, Yhivian, Pérez-García, Felipe, Pozo-Laderas, Juan Carlos, Ricart, Pilar, Sagredo, Víctor, Sánchez-Miralles, Ángel, Chinesta, Susana Sancho, Serra-Fortuny, Mireia, Socias, Lorenzo, Solé-Violan, Jordi, Suárez-Sipmann, Fernando, Lomas, Luis Tamayo, Trenado, José, Úbeda, Alejandro, Valdivia, Luis Jorge, Vidal, Pablo, and Barbé, Ferran

Published
2022
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7. Correction to: The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Author

Torres, Antoni, Motos, Anna, Riera, Jordi, Fernández-Barat, Laia, Ceccato, Adrián, Pérez-Arnal, Raquel, García-Gasulla, Dario, Peñuelas, Oscar, Lorente, José Angel, Rodriguez, Alejandro, de Gonzalo-Calvo, David, Almansa, Raquel, Gabarrús, Albert, Menéndez, Rosario, Bermejo-Martin, Jesús F., Ferrer, Ricard, Amaya Villar, Rosario, Añón, José M., Barberà, Carme, Barberán, José, Blandino Ortiz, Aaron, Bustamante-Munguira, Elena, Caballero, Jesús, Carbajales, Cristina, Carbonell, Nieves, Catalán-González, Mercedes, Galbán, Cristóbal, Gumucio-Sanguino, Víctor D., de la Torre, Maria del Carmen, Díaz, Emili, Estella, Ángel, Gallego, Elena, García Garmendia, José Luis, Garnacho-Montero, José, Gómez, José M., Huerta, Arturo, Jorge García, Ruth Noemí, Loza-Vázquez, Ana, Marin-Corral, Judith, Martínez de la Gándara, Amalia, Martínez Varela, Ignacio, López Messa, Juan, M. Albaiceta, Guillermo, Novo, Mariana Andrea, Peñasco, Yhivian, Pozo-Laderas, Juan Carlos, Ricart, Pilar, Salvador-Adell, Inmaculada, Sánchez-Miralles, Angel, Sancho Chinesta, Susana, Socias, Lorenzo, Solé-Violan, Jordi, Suares Sipmann, Fernando, Tamayo Lomas, Luis, Trenado, José, and Barbé, Ferran

Published
2021
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8. The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Author

Torres, Antoni, Motos, Anna, Riera, Jordi, Fernández-Barat, Laia, Ceccato, Adrián, Pérez-Arnal, Raquel, García-Gasulla, Dario, Peñuelas, Oscar, Lorente, José Angel, Rodriguez, Alejandro, de Gonzalo-Calvo, David, Almansa, Raquel, Gabarrús, Albert, Menéndez, Rosario, Bermejo-Martin, Jesús F., Ferrer, Ricard, Amaya Villar, Rosario, Añón, José M., Barberà, Carme, Barberán, José, Blandino Ortiz, Aaron, Bustamante-Munguira, Elena, Caballero, Jesús, Carbajales, Cristina, Carbonell, Nieves, Catalán-González, Mercedes, Galbán, Cristóbal, Gumucio-Sanguino, Víctor D., de la Torre, Maria del Carmen, Díaz, Emili, Estella, Ángel, Gallego, Elena, García Garmendia, José Luis, Garnacho-Montero, José, Gómez, José M., Huerta, Arturo, Jorge García, Ruth Noemí, Loza-Vázquez, Ana, Marin-Corral, Judith, Martínez de la Gándara, Amalia, Martínez Varela, Ignacio, López Messa, Juan, M. Albaiceta, Guillermo, Novo, Mariana Andrea, Peñasco, Yhivian, Pozo-Laderas, Juan Carlos, Ricart, Pilar, Salvador-Adell, Inmaculada, Sánchez-Miralles, Angel, Sancho Chinesta, Susana, Socias, Lorenzo, Solé-Violan, Jordi, Suares Sipmann, Fernando, Tamayo Lomas, Luis, Trenado, José, and Barbé, Ferran

Published
2021
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9. Remdesivir and survival outcomes in critically ill patients with COVID-19: A multicentre observational cohort study

Author

Cillóniz, Catia, primary, Motos, Anna, additional, Castañeda, Tatiana, additional, Gabarrús, Albert, additional, Barbé, Ferran, additional, Torres, Antoni, additional, Gumucio-Sanguino, Víctor D., additional, Mañez, Rafael, additional, Solé-Violan, Jordi, additional, de Castro, Felipe Rodríguez, additional, Suarez-Sipmann, Fernando, additional, García, Ruth Noemí Jorge, additional, Aznar, María Mora, additional, Torres, Mateu, additional, Martinez, María, additional, Alegre, Cynthia, additional, Riera, Jordi, additional, Contreras, Sofía, additional, Pericas, Juan Manuel, additional, Ferrer, Ricard, additional, Caballero, Jesús, additional, Trujillano, Javier, additional, Vallverdú, Montse, additional, León, Miguel, additional, Badía, Mariona, additional, Balsera, Begoña, additional, Servià, Lluís, additional, Vilanova, Judit, additional, Rodríguez, Silvia, additional, Montserrat, Neus, additional, Iglesias, Silvia, additional, Prados, Javier, additional, Carvalho, Sula, additional, Miralbés, Mar, additional, Monclou, Josman, additional, Jiménez, Gabriel, additional, Codina, Jordi, additional, Val, Estela, additional, Pagliarani, Pablo, additional, Rubio, Jorge, additional, Morales, Dulce, additional, Pujol, Andrés, additional, Furro, Àngels, additional, García, Beatriz, additional, Torres, Gerard, additional, Vengoechea, Javier, additional, Gonzalo-Calvo, David de, additional, González, Jessica, additional, Gomez, Silvia, additional, Gómez, José M., additional, Franco, Nieves, additional, Barberán, José, additional, Albaiceta, Guillermo M, additional, Espina, Lorena Forcelledo, additional, Prieto, Emilio García, additional, Vicente, Paula Martín, additional, del Busto Martínez, Cecilia, additional, Vidal-Cortés, Pablo, additional, Garmendia, José Luis García, additional, Cabello, María Aguilar, additional, Fernández, Carmen Eulalia Martínez, additional, Carbonell, Nieves, additional, Cortés, María Luisa Blasco, additional, Lázaro, Ainhoa Serrano, additional, Díaz, Mar Juan, additional, Ortiz, Aaron Blandino, additional, Menendez, Rosario, additional, Valdivia, Luis Jorge, additional, Boado, María Victoria, additional, Chinesta, Susana Sancho, additional, del Carmen de la Torre, Maria, additional, Varela, Ignacio Martínez, additional, Vieiro, María Teresa Bouza, additional, Arijón, Inés Esmorís, additional, Hermoso, David Campi, additional, Salinas, Rafaela Nogueras, additional, Monjo, Teresa Farre, additional, Bou, Ramon Nogue, additional, Naya, Gregorio Marco, additional, Barberà, Carme, additional, Coll, Núria Ramon, additional, Catalán-González, Mercedes, additional, Montejo-González, Juan Carlos, additional, Sanchez-Giron, Gloria Renedo, additional, Bustamante-Munguira, Juan, additional, Bustamante-Munguira, Elena, additional, Avila, Ramon Cicuendez, additional, Herrera, Nuria Mamolar, additional, Almansa, Raquel, additional, Ortega, Alicia, additional, Bermejo-Martin, Jesús, additional, Sagredo, Víctor, additional, Añon, Jose, additional, Agrifoglio, Alexander, additional, Cachafeiro, Lucia, additional, Maseda, Emilio, additional, Socias, Lorenzo, additional, Novo, Mariana Andrea, additional, Figueras, Albert, additional, Janer, Maria Teresa, additional, Soliva, Laura, additional, Ocón, Marta, additional, Clar, Luisa, additional, Ayestarán, J Ignacio, additional, Peñasco, Yhivian, additional, Fernández, Sandra Campos, additional, Serra-Fortuny, Mireia, additional, Forcadell-Ferreres, Eva, additional, Salvador-Adell, Immaculada, additional, Bofill, Neus, additional, Adell-Serrano, Berta, additional, Díaz, Josep Pedregosa, additional, Casacuberta-Barberà, Núria, additional, Urrelo-Cerrón, Luis, additional, Piñol-Tena, Àngels, additional, Roche-Campo, Ferran, additional, de la Gándara, Amalia Martínez, additional, Murúa, Pablo Ryan, additional, Ruíz, Covadonga Rodríguez, additional, García, Laura Carrión, additional, Álvarez, Juan I Lazo, additional, Lorente, José Ángel, additional, Loza-Vázquez, Ana, additional, Guerrero, Desire Macias, additional, Huerta, Arturo, additional, Tognetti, Daniel, additional, Redruello, Carlos García, additional, Rodríguez, David Mosquera, additional, Fernández, Eva María Menor, additional, Adrio, Sabela Vara, additional, Casal, Vanesa Gómez, additional, Pensado, Marta Segura, additional, Vilas, María Digna Rivas, additional, Sagastume, Amaia García, additional, de Pablo Sánchez, Raul, additional, Laguna, David Pestaña, additional, Bardi, Tommaso, additional, Villar, Rosario Amaya, additional, Gonzalez, Carmen Gómez, additional, Castillo, Maria Luisa Gascón, additional, Garnacho-Montero, José, additional, Cantón-Bulnes, María Luisa, additional, Marin-Corral, Judith, additional, Pérez, Cristina Carbajales, additional, Masclans, Joan Ramon, additional, Degracia, Ana Salazar, additional, Bigas, Judit, additional, Muñoz-Bermúdez, Rosana, additional, Vilà-Vilardel, Clara, additional, Parrilla, Francisco, additional, Dot, Irene, additional, Zapatero, Ana, additional, Díaz, Yolanda, additional, Gracia, María Pilar, additional, Pérez, Purificación, additional, Castellví, Andrea, additional, Climent, Cristina, additional, Serra, Lidia, additional, Barbena, Laura, additional, Cano, Iosune, additional, Ricart, Pilar, additional, Herraiz, Alba, additional, Marcos, Pilar, additional, Rodríguez, Laura, additional, Sariñena, Maria Teresa, additional, Sánchez, Ana, additional, Úbeda, Alejandro, additional, Delgado, María Cruz Martin, additional, Gallego, Elena, additional, Jimenez, Juan Fernando Masa, additional, Gomà, Gemma, additional, Díaz, Emi, additional, Ibarz, Mercedes, additional, De Mendoza, Diego, additional, Barbeta, Enric, additional, Alcaraz-Serrano, Victoria, additional, Badia, Joan Ramon, additional, Castella, Manuel, additional, Bueno, Leticia, additional, Ceccato, Adrian, additional, Palomeque, Andrea, additional, Barat, Laia Fernandez, additional, Cillóniz, Catia, additional, Conde, Pamela, additional, Fernández, Javier, additional, Gabarrus, Albert, additional, Kiarostami, Karsa, additional, López-Gavín, Alexandre, additional, Mantellini, Cecilia L, additional, Speziale, Carla, additional, Vázquez, Nil, additional, Yang, Hua, additional, Yang, Minlan, additional, Ferrando, Carlos, additional, Castro, Pedro, additional, Arrieta, Marta, additional, Nicolas, Jose Maria, additional, Andrea, Rut, additional, Barroso, Marta, additional, Pérez, Raquel, additional, Álvarez, Sergio, additional, Garcia-Gasulla, Dario, additional, Tormos, Adrián, additional, Lomas, Luis Tamayo, additional, Aldecoa, Cesar, additional, Herrán-Monge, Rubén, additional, García, José Ángel Berezo, additional, Giraudo, Pedro Enríquez, additional, Fernández, Pablo Cardinal, additional, López, Alberto Rubio, additional, Pravia, Orville Báez, additional, Messa, Juan López, additional, Bastida, Leire Pérez, additional, Ruiz, Antonjo Alvarez, additional, Trenado, José, additional, Pous, Anna Parera, additional, Galbán, Cristóbal, additional, Lago, Ana López, additional, Paz, Eva Saborido, additional, Segade, Patricia Barral, additional, Mariño, Ana Balan, additional, Mendez, Manuel Valledor, additional, de Frutos, Raúl, additional, Aguilera, Luciano, additional, Pérez-García, Felipe, additional, López-Ramos, Esther, additional, Ruiz-García, Ángela Leonor, additional, Beteré, Belén, additional, Blancas, Rafael, additional, Dólera, Cristina, additional, Planelles, Gloria Perez, additional, Peis, Enrique Marmol, additional, Juan, Maria Dolores Martinez, additional, Miralles, Miriam Ruiz, additional, Rubio, Eva Perez, additional, Martin-Montalvo, Maria Van der Hofstadt, additional, Sánchez-Miralles, Ángel, additional, Warrington, Tatiana Villada, additional, Pozo-Laderas, Juan Carlos, additional, Estrella, Angel, additional, Cano, Sara Guadalupe Moreno, additional, Gordo, Federico, additional, Palacios, Basilisa Martinez, additional, Nieto, Maite, additional, Nieto, Maria Teresa, additional, Ossa, Sergio, additional, Ortega, Ana, additional, Sanchez, Miguel, additional, and Santacoloma, Bitor, additional

Published
2023
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10. Key Factors Associated With Pulmonary Sequelae in the Follow-Up of Critically Ill COVID-19 Patients

Author

González, Jessica, primary, de Batlle, Jordi, additional, Benítez, Iván D., additional, Torres, Gerard, additional, Santisteve, Sally, additional, Targa, Adriano D.S., additional, Gort-Paniello, Clara, additional, Moncusí-Moix, Anna, additional, Aguilà, Maria, additional, Seck, Fatty, additional, Ceccato, Adrián, additional, Ferrer, Ricard, additional, Motos, Anna, additional, Riera, Jordi, additional, Fernández, Laia, additional, Menéndez, Rosario, additional, Lorente, José Ángel, additional, Peñuelas, Oscar, additional, Garcia-Gasulla, Dario, additional, Peñasco, Yhivian, additional, Ricart, Pilar, additional, Abril Palomares, Elena, additional, Aguilera, Luciano, additional, Rodríguez, Alejandro, additional, Boado Varela, Maria Victoria, additional, Beteré, Belén, additional, Pozo-Laderas, Juan Carlos, additional, Solé-Violan, Jordi, additional, Salvador-Adell, Inmaculada, additional, Novo, Mariana Andrea, additional, Barberán, José, additional, Amaya Villar, Rosario, additional, Garnacho-Montero, José, additional, Gómez, José M., additional, Blandino Ortiz, Aaron, additional, Tamayo Lomas, Luis, additional, Úbeda, Alejandro, additional, Catalán-González, Mercedes, additional, Sánchez-Miralles, Angel, additional, Martínez Varela, Ignacio, additional, Jorge García, Ruth Noemí, additional, Franco, Nieves, additional, Gumucio-Sanguino, Víctor D., additional, Bustamante-Munguira, Elena, additional, Valdivia, Luis Jorge, additional, Caballero, Jesús, additional, Gallego, Elena, additional, Rodríguez, Covadonga, additional, Castellanos-Ortega, Álvaro, additional, Trenado, Josep, additional, Marin-Corral, Judith, additional, Albaiceta, Guillermo M., additional, de la Torre, Maria del Carmen, additional, Loza-Vázquez, Ana, additional, Vidal, Pablo, additional, Añón, Jose M., additional, Carbajales Pérez, Cristina, additional, Sagredo, Victor, additional, Carbonell, Nieves, additional, Socias, Lorenzo, additional, Barberà, Carme, additional, Estella, Angel, additional, Diaz, Emili, additional, de Gonzalo-Calvo, David, additional, Torres, Antoni, additional, Barbé, Ferran, additional, Cabello, María Aguilar, additional, Alcaraz-Serrano, Victoria, additional, Aldecoa, Cesar, additional, Alegre, Cynthia, additional, Calderón, Ángela Algaba, additional, Álvarez, Sergio, additional, Ruiz, Antonio Álvarez, additional, Andrea, Ruth, additional, Aparicio, Maria de Alba, additional, Arrieta, Marta, additional, Ayestarán, J. Ignacio, additional, Badia, Joan Ramon, additional, Badía, Mariona, additional, Pravia, Orville Báez, additional, Mariño, Ana Balan, additional, Balsera, Begoña, additional, Barbena, Laura, additional, Barbeta, Enric, additional, Bardi, Tommaso, additional, Segade, Patricia Barral, additional, Barroso, Marta, additional, García, José Ángel Berezo, additional, Bermejo, Jesus, additional, Bigas, Judit, additional, Blancas, Rafael, additional, Cortés, María Luisa Blasco, additional, Saera, María Bodi, additional, Bofill, Neus, additional, Vieiro, María Teresa Bouza, additional, Bueno, Leticia, additional, Bustamante-Munguira, Juan, additional, Martínez, Cecilia del Busto, additional, Hermoso, David Campi, additional, Fernández, Sandra Campos, additional, Cano, Iosune, additional, Canseco, Joan, additional, Fernández, Pablo Cardinal, additional, García, Laura Carrión, additional, Carvalho, Sulamita, additional, Castellà, Manuel, additional, Castellví, Andrea, additional, Castro, Pedro, additional, Centelles-Serrano, María José, additional, Ávila, Ramon Cicuendez, additional, Cillóniz, Catia, additional, Clar, Luisa, additional, Climent, Cristina, additional, Codina, Jordi, additional, Conde, Pamela, additional, Contreras, Sofía, additional, Parra, Raul de Frutos, additional, Sánchez, Raul de Pablo, additional, Mendoza, Diego De, additional, Díaz, Yolanda, additional, Vilas, María Digna Rivas, additional, Moreno, Cristina Dólera, additional, Dot, Irene, additional, Giraudo, Pedro Enríquez, additional, Arijón, Inés Esmorís, additional, Monjo, Teresa Farre, additional, Fernández, Javier, additional, Ferrando, Carlos, additional, Figueras, Albert, additional, Espina, Lorena Forcelledo, additional, Franquesa, Enric, additional, Furro, Àngels, additional, Gabarrus, Albert, additional, Galbán, Cristóbal, additional, García, Felipe, additional, García, Beatriz, additional, Prieto, Emilio García, additional, Redruello, Carlos García, additional, Sagastume, Amaia García, additional, Castillo, Maria Luisa Gascón, additional, Gomà, Gemma, additional, Casal, Vanesa Gómez, additional, Gómez, Silvia, additional, Gonzalez, Carmen Gómez, additional, Gordo, Federico, additional, Gracia, Maria Pilar, additional, Fernández, María José Gutierrez, additional, Herraiz, Alba, additional, Herrán-Monge, Rubén, additional, Ibarz, Mercedes, additional, Iglesias, Silvia, additional, Janer, Maria Teresa, additional, Jiménez, Gabriel, additional, Díaz, Mar Juan, additional, Kiarostami, Karsa, additional, Álvarez, Juan I. Lazo, additional, León, Miguel, additional, López-Gavín, Alexandre, additional, Guerrero, Desiree Macias, additional, Herrera, Nuria Mamolar, additional, Mendiluce, Rafael Mañez, additional, Mantellini, Cecilia L., additional, Naya, Gregorio Marco, additional, Barcos, Iris Marco, additional, Marcos, Pilar, additional, Peis, Enrique Marmol, additional, Cuadrado, Marta Martín, additional, Delgado, María Cruz Martin, additional, Vicente, Paula Martín, additional, Martínez, María, additional, Fernández, Carmen Eulalia Martínez, additional, Juan, Maria Dolores Martínez, additional, Palacios, Basilisa Martínez, additional, Jimenez, Juan Fernando Masa, additional, Masclans, Joan Ramon, additional, Maseda, Emilio, additional, Fernández, Eva María Menor, additional, Banderas, Priscila Metora, additional, Minguez, Olga, additional, Miralbés, Mar, additional, Monclou, Josman, additional, Montejo-González, Juan Carlos, additional, Montserrat, Neus, additional, Aznar, María Mora, additional, Morales, Dulce, additional, Cano, Sara Guadalupe Moreno, additional, Rodríguez, David Mosquera, additional, Muñoz-Bermúdez, Rosana, additional, Nicolás, José María, additional, Bou, Ramon Nogue, additional, Salinas, Rafaela Nogueras, additional, Ocón, Marta, additional, Ortega, Ana, additional, Ossa, Sergio, additional, Pagliarani, Pablo, additional, Parrilla, Francisco, additional, Pedregosa-Díaz, José, additional, Bastida, Leire Pérez, additional, Pérez, Purificación, additional, Pérez-García, Felipe, additional, Planelles, Gloria Pérez, additional, Rubio, Eva Pérez, additional, Laguna, David Pestaña, additional, Prados, Javier, additional, Pujol, Andrés, additional, Coll, Núria Ramon, additional, Sanchez-Giron, Gloria Renedo, additional, Roche-Campo, Ferran, additional, Rodriguez, Laura, additional, Castro, Felipe Rodríguez de, additional, Rodríguez, Silvia, additional, Ruiz, Covadonga Rodríguez, additional, Rubio, Jorge, additional, López, Alberto Rubio, additional, Ruiz-García, Ángela Leonor, additional, Miralles, Miriam Ruiz, additional, Murúa, Pablo Ryan, additional, Paz, Eva Saborido, additional, Degracia, Ana Salazar, additional, Sanchez, Miguel, additional, Sánchez, Ana, additional, Chinesta, Susana Sancho, additional, Santacoloma, Bitor, additional, Sariñena, Maria Teresa, additional, Pensado, Marta Segura, additional, Serra, Lidia, additional, Serra-Fortuny, Mireia, additional, Lázaro, Ainhoa Serrano, additional, Servià, Lluís, additional, Soliva, Laura, additional, Speziale, Carla, additional, Tormos, Adrián, additional, Torres, Mateu, additional, Tranque-Liberal, Celia, additional, Trefler, Sandra, additional, Trujillano, Javier, additional, Vaca, Rafaela, additional, Val, Estela, additional, Ruiz, Luis Valdivia, additional, Vallverdú, Montserrat, additional, Martin-Montalvo, Maria Van der Hofstadt, additional, Adrio, Sabela Vara, additional, Vázquez, Nil, additional, Vengoechea, Javier, additional, Vilà-Vilardel, Clara, additional, Vilanova, Judit, additional, Warrington, Tatiana Villada, additional, Yang, Hua, additional, Yang, Minlan, additional, and Zapatero, Ana, additional

Published
2023
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12. Remdesivir and survival outcomes in critically ill patients with COVID-19: A multicentre observational cohort study

Author

Gumucio-Sanguino, Víctor D., Mañez, Rafael, Solé-Violan, Jordi, de Castro, Felipe Rodríguez, Suarez-Sipmann, Fernando, García, Ruth Noemí Jorge, Aznar, María Mora, Torres, Mateu, Martinez, María, Alegre, Cynthia, Riera, Jordi, Contreras, Sofía, Pericas, Juan Manuel, Ferrer, Ricard, Caballero, Jesús, Trujillano, Javier, Vallverdú, Montse, León, Miguel, Badía, Mariona, Balsera, Begoña, Servià, Lluís, Vilanova, Judit, Rodríguez, Silvia, Montserrat, Neus, Iglesias, Silvia, Prados, Javier, Carvalho, Sula, Miralbés, Mar, Monclou, Josman, Jiménez, Gabriel, Codina, Jordi, Val, Estela, Pagliarani, Pablo, Rubio, Jorge, Morales, Dulce, Pujol, Andrés, Furro, Àngels, García, Beatriz, Torres, Gerard, Vengoechea, Javier, Gonzalo-Calvo, David de, González, Jessica, Gomez, Silvia, Gómez, José M., Franco, Nieves, Barberán, José, Albaiceta, Guillermo M, Espina, Lorena Forcelledo, Prieto, Emilio García, Vicente, Paula Martín, del Busto Martínez, Cecilia, Vidal-Cortés, Pablo, Garmendia, José Luis García, Cabello, María Aguilar, Fernández, Carmen Eulalia Martínez, Carbonell, Nieves, Cortés, María Luisa Blasco, Lázaro, Ainhoa Serrano, Díaz, Mar Juan, Ortiz, Aaron Blandino, Menendez, Rosario, Valdivia, Luis Jorge, Boado, María Victoria, Chinesta, Susana Sancho, del Carmen de la Torre, Maria, Varela, Ignacio Martínez, Vieiro, María Teresa Bouza, Arijón, Inés Esmorís, Hermoso, David Campi, Salinas, Rafaela Nogueras, Monjo, Teresa Farre, Bou, Ramon Nogue, Naya, Gregorio Marco, Barberà, Carme, Coll, Núria Ramon, Catalán-González, Mercedes, Montejo-González, Juan Carlos, Sanchez-Giron, Gloria Renedo, Bustamante-Munguira, Juan, Bustamante-Munguira, Elena, Avila, Ramon Cicuendez, Herrera, Nuria Mamolar, Almansa, Raquel, Ortega, Alicia, Bermejo-Martin, Jesús, Sagredo, Víctor, Añon, Jose, Agrifoglio, Alexander, Cachafeiro, Lucia, Maseda, Emilio, Socias, Lorenzo, Novo, Mariana Andrea, Figueras, Albert, Janer, Maria Teresa, Soliva, Laura, Ocón, Marta, Clar, Luisa, Ayestarán, J Ignacio, Peñasco, Yhivian, Fernández, Sandra Campos, Serra-Fortuny, Mireia, Forcadell-Ferreres, Eva, Salvador-Adell, Immaculada, Bofill, Neus, Adell-Serrano, Berta, Díaz, Josep Pedregosa, Casacuberta-Barberà, Núria, Urrelo-Cerrón, Luis, Piñol-Tena, Àngels, Roche-Campo, Ferran, de la Gándara, Amalia Martínez, Murúa, Pablo Ryan, Ruíz, Covadonga Rodríguez, García, Laura Carrión, Álvarez, Juan I Lazo, Lorente, José Ángel, Loza-Vázquez, Ana, Guerrero, Desire Macias, Huerta, Arturo, Tognetti, Daniel, Redruello, Carlos García, Rodríguez, David Mosquera, Fernández, Eva María Menor, Adrio, Sabela Vara, Casal, Vanesa Gómez, Pensado, Marta Segura, Vilas, María Digna Rivas, Sagastume, Amaia García, de Pablo Sánchez, Raul, Laguna, David Pestaña, Bardi, Tommaso, Villar, Rosario Amaya, Gonzalez, Carmen Gómez, Castillo, Maria Luisa Gascón, Garnacho-Montero, José, Cantón-Bulnes, María Luisa, Marin-Corral, Judith, Pérez, Cristina Carbajales, Masclans, Joan Ramon, Degracia, Ana Salazar, Bigas, Judit, Muñoz-Bermúdez, Rosana, Vilà-Vilardel, Clara, Parrilla, Francisco, Dot, Irene, Zapatero, Ana, Díaz, Yolanda, Gracia, María Pilar, Pérez, Purificación, Castellví, Andrea, Climent, Cristina, Serra, Lidia, Barbena, Laura, Cano, Iosune, Ricart, Pilar, Herraiz, Alba, Marcos, Pilar, Rodríguez, Laura, Sariñena, Maria Teresa, Sánchez, Ana, Úbeda, Alejandro, Delgado, María Cruz Martin, Gallego, Elena, Jimenez, Juan Fernando Masa, Gomà, Gemma, Díaz, Emi, Ibarz, Mercedes, De Mendoza, Diego, Barbeta, Enric, Alcaraz-Serrano, Victoria, Badia, Joan Ramon, Castella, Manuel, Bueno, Leticia, Ceccato, Adrian, Palomeque, Andrea, Barat, Laia Fernandez, Cillóniz, Catia, Conde, Pamela, Fernández, Javier, Gabarrus, Albert, Kiarostami, Karsa, López-Gavín, Alexandre, Mantellini, Cecilia L, Speziale, Carla, Vázquez, Nil, Yang, Hua, Yang, Minlan, Ferrando, Carlos, Castro, Pedro, Arrieta, Marta, Nicolas, Jose Maria, Andrea, Rut, Barroso, Marta, Pérez, Raquel, Álvarez, Sergio, Garcia-Gasulla, Dario, Tormos, Adrián, Lomas, Luis Tamayo, Aldecoa, Cesar, Herrán-Monge, Rubén, García, José Ángel Berezo, Giraudo, Pedro Enríquez, Fernández, Pablo Cardinal, López, Alberto Rubio, Pravia, Orville Báez, Messa, Juan López, Bastida, Leire Pérez, Ruiz, Antonjo Alvarez, Trenado, José, Pous, Anna Parera, Galbán, Cristóbal, Lago, Ana López, Paz, Eva Saborido, Segade, Patricia Barral, Mariño, Ana Balan, Mendez, Manuel Valledor, de Frutos, Raúl, Aguilera, Luciano, Pérez-García, Felipe, López-Ramos, Esther, Ruiz-García, Ángela Leonor, Beteré, Belén, Blancas, Rafael, Dólera, Cristina, Planelles, Gloria Perez, Peis, Enrique Marmol, Juan, Maria Dolores Martinez, Miralles, Miriam Ruiz, Rubio, Eva Perez, Martin-Montalvo, Maria Van der Hofstadt, Sánchez-Miralles, Ángel, Warrington, Tatiana Villada, Pozo-Laderas, Juan Carlos, Estrella, Angel, Cano, Sara Guadalupe Moreno, Gordo, Federico, Palacios, Basilisa Martinez, Nieto, Maite, Nieto, Maria Teresa, Ossa, Sergio, Ortega, Ana, Sanchez, Miguel, Santacoloma, Bitor, Motos, Anna, Castañeda, Tatiana, Gabarrús, Albert, Barbé, Ferran, and Torres, Antoni

Published
2023
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13. Prognostic implications of comorbidity patterns in critically ill COVID-19 patients: A multicenter, observational study

Author

Benítez, Iván D., primary, de Batlle, Jordi, additional, Torres, Gerard, additional, González, Jessica, additional, de Gonzalo-Calvo, David, additional, Targa, Adriano D.S., additional, Gort-Paniello, Clara, additional, Moncusí-Moix, Anna, additional, Ceccato, Adrián, additional, Fernández-Barat, Laia, additional, Ferrer, Ricard, additional, Garcia-Gasulla, Dario, additional, Menéndez, Rosario, additional, Motos, Anna, additional, Peñuelas, Oscar, additional, Riera, Jordi, additional, Bermejo-Martin, Jesús F., additional, Peñasco, Yhivian, additional, Ricart, Pilar, additional, Martin Delgado, María Cruz, additional, Aguilera, Luciano, additional, Rodríguez, Alejandro, additional, Boado Varela, Maria Victoria, additional, Suarez-Sipmann, Fernando, additional, Pozo-Laderas, Juan Carlos, additional, Solé-Violan, Jordi, additional, Nieto, Maite, additional, Novo, Mariana Andrea, additional, Barberán, José, additional, Amaya Villar, Rosario, additional, Garnacho-Montero, José, additional, García-Garmendia, Jose Luis, additional, Gómez, José M., additional, Lorente, José Ángel, additional, Blandino Ortiz, Aaron, additional, Tamayo Lomas, Luis, additional, López-Ramos, Esther, additional, Úbeda, Alejandro, additional, Catalán-González, Mercedes, additional, Sánchez-Miralles, Angel, additional, Martínez Varela, Ignacio, additional, Jorge García, Ruth Noemí, additional, Franco, Nieves, additional, Gumucio-Sanguino, Víctor D., additional, Huerta Garcia, Arturo, additional, Bustamante-Munguira, Elena, additional, Valdivia, Luis Jorge, additional, Caballero, Jesús, additional, Gallego, Elena, additional, Martínez de la Gándara, Amalia, additional, Castellanos-Ortega, Álvaro, additional, Trenado, Josep, additional, Marin-Corral, Judith, additional, Albaiceta, Guillermo M, additional, de la Torre, Maria del Carmen, additional, Loza-Vázquez, Ana, additional, Vidal, Pablo, additional, Lopez Messa, Juan, additional, Añón, Jose M., additional, Carbajales Pérez, Cristina, additional, Sagredo, Victor, additional, Bofill, Neus, additional, Carbonell, Nieves, additional, Socias, Lorenzo, additional, Barberà, Carme, additional, Estella, Angel, additional, Valledor Mendez, Manuel, additional, Diaz, Emili, additional, López Lago, Ana, additional, Torres, Antoni, additional, and Barbé, Ferran, additional

Published
2022
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14. Prognostic implications of comorbidity patterns in critically ill COVID-19 patients: A multicenter, observational study

Author

Benítez, Iván D., Batlle, Jordi de, Torres, Gerard, González, Jessica, Gonzalo Calvo, David de, Targa, Adriano D.S., Gort Paniello, Clara, Moncusí Moix, Anna, Ceccato, Adrian, Fernández Barat, Laia, Ferrer, Ricard, Garcia Gasulla, Dario, Menéndez, Rosario, Motos, Anna, Peñuelas, Oscar, Riera, Jordi, Bermejo Martin, Jesús F., Peñasco, Yhivian, Ricart, Pilar, Martin Delgado, María Cruz, Aguilera, Luciano, Rodríguez, Alejandro, Boado Varela, Maria Victoria, Suarez Sipmann, Fernando, Pozo Laderas, Juan Carlos, Solé Violan, Jordi, Nieto, Maite, Novo, Mariana Andrea, Barberán, José, Amaya Villar, Rosario, Garnacho Montero, José, García Garmendia, José Luis, Gómez, José M., Lorente, José Ángel, Blandino Ortiz, Aaron, Tamayo Lomas, Luis, López Ramos, Esther, Úbeda, Alejandro, Catalán González, Mercedes, Sánchez Miralles, Angel, Martínez Varela, Ignacio, Jorge García, Ruth Noemí, Franco, Nieves, Gumucio Sanguino, Víctor D., Huerta Garcia, Arturo, Bustamante Munguira, Elena, Valdivia, Luis Jorge, Caballero, Jesús, Gallego, Elena, Martínez de la Gándara, Amalia, Castellanos Ortega, Álvaro, Trenado, Josep, Marin Corral, Judith, Albaiceta, Guillermo M., De La Torre, Maria Del Carmen, Loza-vázquez, Ana, Vidal, Pablo, Lopez Messa, Juan, Añón, José M., Carbajales Pérez, Cristina, Sagredo, Victor, Bofill, Neus, Carbonell, Nieves, Socias, Lorenzo, Barberà, Carme, Estella, Ángel, Valledor Mendez, Manuel, Diaz, Emili, López Lago, Ana, Torres, Antoni, Barbé, Ferran, CIBERESUCICOVID Project (COV20/00110, ISCIII), Universitat Politècnica de Catalunya. Departament de Ciències de la Computació, Barcelona Supercomputing Center, and Universitat Politècnica de Catalunya. KEMLG - Grup d'Enginyeria del Coneixement i Aprenentatge Automàtic

Subjects
Informàtica::Intel·ligència artificial::Aprenentatge automàtic [Àrees temàtiques de la UPC], Critical Care, Health Policy, COVID-19, Comorbidity, Prognosis, COVID-19 (Malaltia), COVID-19 (Disease), Medicina intensiva, Oncology, Comorbiditat, Ciències de la salut::Medicina::Medicina comunitària i salut pública [Àrees temàtiques de la UPC], mental disorders, Internal Medicine, Critical care medicine
Abstract

Financial support was provided by Instituto de Salud Carlos III (CIBERESUCICOVID, COV20/00110), co- funded by Fondo Europeo de Desarrollo Regional (FEDER), “Una manera de hacer Europa”, Centro de Investigaci on Biom edica en Red − Enfermedades Res- piratorias (CIBERES) and Donation Program “estar pre- parados”, UNESPA, Madrid, Spain. JdB acknowledges receiving financial support from Instituto de Salud Car- los III (ISCIII; Miguel Servet 2019: CP19/00108), co- funded by the European Social Fund (ESF), “Investing in your future”. DdGC acknowledges receiving financial support from Instituto de Salud Carlos III (ISCIII; Miguel Servet 2019: CP20/00041), co-funded by the European Social Fund (ESF), “Investing in your future”. AC acknowledges receiving financial support from Instituto de Salud Carlos III (ISCIII; Sara Borrell 2021: CD21/00087)., Benítez ID, de Batlle J, Torres G, González J, de Gonzalo-Calvo D, Targa ADS, Gort-Paniello C, Moncusí-Moix A, Ceccato A, Fernández-Barat L, Ferrer R, Garcia-Gasulla D, Menéndez R, Motos A, Peñuelas O, Riera J, Bermejo-Martin JF, Peñasco Y, Ricart P, Martin Delgado MC, Aguilera L, Rodríguez A, Boado Varela MV, Suarez-Sipmann F, Pozo-Laderas JC, Solé-Violan J, Nieto M, Novo MA, Barberán J, Amaya Villar R, Garnacho-Montero J, García-Garmendia JL, Gómez JM, Lorente JÁ, Blandino Ortiz A, Tamayo Lomas L, López-Ramos E, Úbeda A, Catalán-González M, Sánchez-Miralles A, Martínez Varela I, Jorge García RN, Franco N, Gumucio-Sanguino VD, Huerta Garcia A, Bustamante-Munguira E, Valdivia LJ, Caballero J, Gallego E, Martínez de la Gándara A, Castellanos-Ortega Á, Trenado J, Marin-Corral J, Albaiceta GM, de la Torre MDC, Loza-Vázquez A, Vidal P, Lopez Messa J, Añón JM, Carbajales Pérez C, Sagredo V, Bofill N, Carbonell N, Socias L, Barberà C, Estella A, Valledor Mendez M, Diaz E, López Lago A, Torres A, Barbé F; CIBERESUCICOVID Project (COV20/00110, ISCIII)

Published
2022

16. Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn)

Author

Salmanton-García, Jon, Seidel, Danila, Koehler, Philipp, Mellinghoff, Sibylle, Herbrecht, Raoul, Klimko, Nikolai, Ráčil, Zdeněk, Falces-Romero, Iker, Ingram, Paul, Benítez-Peñuela, Miguel-Ángel, Rodríguez, José Yesid, Desoubeaux, Guillaume, Barać, Aleksandra, García-Vidal, Carolina, Hoenigl, Martin, Mehta, Sanjay, Cheng, Matthew, Klyasova, Galina, Heinz, Werner, Iqbal, Nousheen, Krause, Robert, Ostermann, Helmut, Penack, Olaf, Schalk, Enrico, Sheppard, Donald, Willinger, Birgit, Wisplinghoff, Hilmar, Vehreschild, J Janne, Cornely, Oliver, Vehreschild, Maria, Khedr, Reham Abdelaziz, Arencibia-Núñez, Alberto, Avilés-Robles, Martha, Banke, Ingo, Basher, Ariful, Benachinamardi, Keertilaxmi, Bertz, Harmut, Chakrabarti, Arunaloke, Drgona, Lubos, García-Martínez, Jesús, García-Rodríguez, Julio, Gräber, Sandra, Härter, Georg, Klein, Michael, Kouba, Michal, Lee, Dong-Gun, Le Govic, Yohann, Leo, Fabian, Maertens, Johan, Maschmeyer, Georg, Meintker, Lisa, Mo, Xiao-Dong, Müller, Lena-Katharina, Müller, Nicolas, Nel, Jeremy Stephen, Novák, Jan, Patel, Atul, Pfäfflin, Frieder, Pozo-Laderas, Juan-Carlos, Puerta-Alcalde, Pedro, Rodríguez-Guardado, Azucena, Schroers, Roland, Shekar, Vandana, Shenoi, Susan, Silling, Gerda, Vinh, Donald, Waizel-Haiat, Salomón, Yee Yee, Mandy Yap, Prakash, Peralam Yegneswaran, Žák, Pavel, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), Service d'Hématologie, CHU Strasbourg, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Medicine, Medical University Graz, Schwerpunkt Infektiologie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Department of Haematology and Oncology, Medical Clinic III, University Hospital Munich—Großhadern, Ludwig Maximilian University, Klinik für Hämatologie und Onkologie, Charité, Campus Benjamin Franklin, Department of Haematology/Oncology, Magdeburg University Hospital, McGill University = Université McGill [Montréal, Canada], Medizinische Universität Wien = Medical University of Vienna, University Hospital of Cologne [Cologne], Postgraduate Institute of Medical Education and Research, Laboratoire de psychologie cognitive (LPC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Anofel Cryptosporidium National Network, Department of Hematology, University Hospital Gasthuisberg, Medizinische Klinik, Hämatologie und Onkologie, Klinikum Ernst von Bergmann, Real Expression Artificial Life (IRIT-REVA), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Medizinische Klinik A des Universitätsklinikums Münster, Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), University Hospital Gasthuisberg [Leuven], Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), and Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, 0301 basic medicine, Posaconazole, Antifungal Agents, [SDV]Life Sciences [q-bio], Gastroenterology, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Amphotericin B, Pharmacology (medical), Prospective Studies, Registries, 030212 general & internal medicine, Child, Prospective cohort study, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, ComputingMilieux_MISCELLANEOUS, Antiinfective agent, Standard treatment, Middle Aged, 3. Good health, Infectious Diseases, Tolerability, Child, Preschool, Mucorales, Female, medicine.drug, Adult, Microbiology (medical), medicine.medical_specialty, Adolescent, Drug Compounding, Matched-Pair Analysis, 030106 microbiology, Young Adult, 03 medical and health sciences, Pharmacokinetics, Internal medicine, parasitic diseases, medicine, Humans, Mucormycosis, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, [INFO]Computer Science [cs], Aged, Pharmacology, business.industry, Infant, Newborn, Infant, Triazoles, medicine.disease, business, MESH: amphotericin b, antifungal agents, cancer, kidney failure, mucormycosis, surgical procedures, operative, suspensions, mortality, posaconazole, Invasive Fungal Infections
Abstract

Background First-line antifungal treatment for invasive mucormycosis (IM) consists of liposomal amphotericin B. Salvage treatment options are limited and often based on posaconazole oral suspension. With the approval of posaconazole new formulations, patients could benefit from improved pharmacokinetics, safety and tolerability. Objectives Our aim was to assess the effectiveness of posaconazole new formulations for IM treatment. Methods We performed a case-matched analysis with proven or probable IM patients from the FungiScope® Registry. First-line posaconazole new formulations (1st-POSnew) and first-line amphotericin B plus posaconazole new formulations (1st-AMB+POSnew) cases were matched with first-line amphotericin B-based (1st-AMB) treatment controls. Salvage posaconazole new formulations (SAL-POSnew) cases were matched with salvage posaconazole oral suspension (SAL-POSsusp) controls. Each case was matched with up to three controls (based on severity, haematological/oncological malignancy, surgery and/or renal dysfunction). Results Five patients receiving 1st-POSnew, 18 receiving 1st-AMB+POSnew and 22 receiving SAL-POSnew were identified. By day 42, a favourable response was reported for 80.0% (n = 4/5) of patients receiving 1st-POSnew, for 27.8% (n = 5/18) receiving 1st-AMB+POSnew and for 50.0% (n = 11/22) receiving SAL-POSnew. Day 42 all-cause mortality of patients receiving posaconazole new formulations was lower compared with controls [20.0% (n = 1/5) in 1st-POSnew versus 53.3% (n = 8/15) in 1st-AMB; 33.3% (n = 6/18) in 1st-AMB+POSnew versus 52.0% (n = 26/50) in 1st-AMB; and 0.0% (n = 0/22) in SAL-POSnew versus 4.4% (n = 2/45) in SAL-POSsusp]. Conclusions Posaconazole new formulations were effective in terms of treatment response and associated mortality of IM. While posaconazole new formulations may be an alternative for treatment of IM, the limited sample size of our study calls for a cautious interpretation of these observations.

Published
2019
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18. Pulmonary Function and Radiologic Features in Survivors of Critical COVID-19

Author

González, Jessica, primary, Benítez, Iván D., additional, Carmona, Paola, additional, Santisteve, Sally, additional, Monge, Aida, additional, Moncusí-Moix, Anna, additional, Gort-Paniello, Clara, additional, Pinilla, Lucía, additional, Carratalá, Amara, additional, Zuil, María, additional, Ferrer, Ricard, additional, Ceccato, Adrián, additional, Fernández, Laia, additional, Motos, Ana, additional, Riera, Jordi, additional, Menéndez, Rosario, additional, Garcia-Gasulla, Dario, additional, Peñuelas, Oscar, additional, Bermejo-Martin, Jesús F., additional, Labarca, Gonzalo, additional, Caballero, Jesus, additional, Torres, Gerard, additional, de Gonzalo-Calvo, David, additional, Torres, Antoni, additional, Barbé, Ferran, additional, Villar, Rosario Amaya, additional, Añón, José M., additional, Barberà, Carme, additional, Barberán, José, additional, Ortiz, Aaron Blandino, additional, Bustamante-Munguira, Elena, additional, Caballero, Jesús, additional, Carbajales, Cristina, additional, Carbonell, Nieves, additional, Catalán-González, Mercedes, additional, Galbán, Cristóbal, additional, Gumucio, Victor Daniel, additional, de la Torre, Maria del Carmen, additional, Díaz, Emili, additional, Estella, Ángel, additional, Gallego, Elena, additional, García Garmendia, José Luis, additional, Garnacho-Montero, José, additional, Gómez, José M., additional, Huerta, Arturo, additional, Jorge García, Ruth Noemí, additional, Loza-Vázquez, Ana, additional, Marin-Corral, Judith, additional, de la Gándara, Amalia Martínez, additional, Varela, Ignacio Martínez, additional, Messa, Juan Lopez, additional, Albaiceta, Guillermo M., additional, Novo, Mariana Andrea, additional, Peñasco, Yhivian, additional, Pozo-Laderas, Juan Carlos, additional, Martí, Pilar Ricart, additional, Roche-Campo, Ferran, additional, Sánchez-Miralles, Angel, additional, Chinesta, Susana Sancho, additional, Socias, Lorenzo, additional, Solé-Violan, Jordi, additional, Sipmann, Fernando Suares, additional, Lomas, Luis Tamayo, additional, and Trenado, José, additional

Published
2021
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19. Additional file 1 of The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Author

Torres, Antoni, Motos, Anna, Riera, Jordi, Fernández-Barat, Laia, Ceccato, Adrián, Pérez-Arnal, Raquel, García-Gasulla, Dario, Peñuelas, Oscar, Lorente, José Angel, Rodriguez, Alejandro, de Gonzalo-Calvo, David, Almansa, Raquel, Gabarrús, Albert, Menéndez, Rosario, Bermejo-Martin, Jesús F., Ferrer, Ricard, Amaya Villar, Rosario, Añón, José M., Barberà, Carme, Barberán, José, Blandino Ortiz, Aaron, Bustamante-Munguira, Elena, Caballero, Jesús, Carbajales, Cristina, Carbonell, Nieves, Catalán-González, Mercedes, Galbán, Cristóbal, Gumucio-Sanguino, Víctor D., de la Torre, Maria del Carmen, Díaz, Emili, Estella, Ángel, Gallego, Elena, García Garmendia, José Luis, Garnacho-Montero, José, Gómez, José M., Huerta, Arturo, Jorge García, Ruth Noemí, Loza-Vázquez, Ana, Marin-Corral, Judith, Martínez de la Gándara, Amalia, Martínez Varela, Ignacio, López Messa, Juan, M. Albaiceta, Guillermo, Novo, Mariana Andrea, Peñasco, Yhivian, Pozo-Laderas, Juan Carlos, Ricart, Pilar, Salvador-Adell, Inmaculada, Sánchez-Miralles, Angel, Sancho Chinesta, Susana, Socias, Lorenzo, Solé-Violan, Jordi, Suares Sipmann, Fernando, Tamayo Lomas, Luis, Trenado, José, and Barbé, Ferran

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, ComputingMilieux_COMPUTERSANDEDUCATION, Data_FILES, ComputerApplications_COMPUTERSINOTHERSYSTEMS
Abstract

Additional file 1. Supplementary tables and figures.

Published
2021
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20. Deploying Machine Learning to Validate Clinical Phenotypes and Factors Associated with Mortality Risk in 2,022 Critically Ill Patients with COVID-19 in Spain

Author

Rodriguez Oviedo, Alejandro, primary, Ruíz-Botella, Manuel, additional, Matín-Loeches, Ignacio, additional, Solé-Violan, Jordi, additional, Gómez, Josep, additional, Bodí, María, additional, Trefler, Sandra, additional, Papiol, Elisabeth, additional, Díaz, Emili, additional, Suberviola, Borja, additional, Vallverdú, Montserrat, additional, Mayor-Vazquez, Eric, additional, Albaya Moreno, Antonio, additional, Canabal Berlanga, Alfonso, additional, Sánchez García, Miguel, additional, del Valle Ortíz, María, additional, Ballesteros, Juan Carlos, additional, Martín Iglesias, Lorena, additional, Marín-Corral, Judith, additional, López Ramos, Esther, additional, Hidalgo Valverde, Virgina, additional, Vidaur, Loreto, additional, Sancho Chinesta, Susana, additional, González de Molina, Francisco Javier, additional, Herrero García, Sandra, additional, Sena Perez, Carmen Carolina, additional, Pozo Laderas, Juan Carlos, additional, Rodríguez García, Raquel, additional, Estella, Angel, additional, and Ferrer, Ricard, additional

Published
2020
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21. Impact of Source Control in Patients With Severe Sepsis and Septic Shock

Author

Luisa Martinez, Maria, Ferrer, Ricard, Torrents, Eva, Gtiillamat-Prats, Raquel, Goma, Gemma, Suarez, David, Alvarez-Rocha, Luis, Pozo Laderas, Juan Carlos, Martin-Loeches, Ignacio, Levy, Mitchell M., Artigas, Antonio, and Edusepsis Study Grp

Subjects
critical care, sepsis, septic shock, infection control, mortality, severe sepsis
Abstract

Objectives: Time to clearance of pathogens is probably critical to outcome in septic shock. Current guidelines recommend intervention for source control within 12 hours after diagnosis. We aimed to determine the epidemiology of source control in the management of sepsis and to analyze the impact of timing to source control on mortality. Design: Prospective observational analysis of the Antibiotic Intervention in Severe Sepsis study, a Spanish national multicenter educational intervention to improve antibiotherapy in sepsis. Setting: Ninety-nine medical-surgical ICUs in Spain. Patients: We enrolled 3,663 patients with severe sepsis. or septic shock during three 4-month periods between 2011 and 2013. Interventions: Source control and hospital mortality. Measurements and Main Results: A total of 1,173 patients (32%) underwent source control, predominantly for abdominal, urinary, and soft-tissue infections. Compared with patients who did not require source control, patients who underwent source control were older, with a greater prevalence of shock, major organ dysfunction, bacteremia, inflammatory markers, and lactic acidemia. In addition, compliance with the resuscitation bundle was worse in those undergoing source control. In patients who underwent source control, crude ICU mortality was lower (21.2% vs 25.1%; p = 0.010); after adjustment for confounding factors, hospital mortality was also lower (odds ratio, 0.809 [95% CI, 0.658-0.994]; p = 0.044). In this observational database analysis, source control after 12 hours was not associated with higher mortality (27.6% vs 26.8%; p = 0.789). Conclusions: Despite greater severity and worse compliance with resuscitation bundles, mortality was lower in septic patients who underwent source control than in those who did not. The time to source control could not be linked to survival in this observational database.

Published
2017

25. Survival of patients receiving a liver transplant for hepatocellular carcinoma, and risk of tumor recurrence

Author

Universidad de Sevilla. Departamento de Cirugía, Solórzano Peck, Guillermo, Briceño, Javier, Padillo Ruiz, Francisco Javier, Díaz Iglesias, Carlos, Marchal Molina, Trinidad, Rufián Peña, Sebastián, Mata García, Manuel de la, Barrera Baena, Pilar, López Cillero, Pedro, Pozo Laderas, Juan Carlos, Montero Álvarez, J. L., Costán Rodero, Guadalupe, Fraga Rivas, Enrique, López Vallejos, P., Pérez de Luque, Daniel, Universidad de Sevilla. Departamento de Cirugía, Solórzano Peck, Guillermo, Briceño, Javier, Padillo Ruiz, Francisco Javier, Díaz Iglesias, Carlos, Marchal Molina, Trinidad, Rufián Peña, Sebastián, Mata García, Manuel de la, Barrera Baena, Pilar, López Cillero, Pedro, Pozo Laderas, Juan Carlos, Montero Álvarez, J. L., Costán Rodero, Guadalupe, Fraga Rivas, Enrique, López Vallejos, P., and Pérez de Luque, Daniel

Abstract

Objective: the goal of this research has been to evaluate the survival, in long and short term, of the patient receiving liver transplant for hepatocellular carcinoma (HCC), the risk of posttransplant tumor relapse and factors related to this complication. Design: retrospective study of a consecutive series of patients having had liver transplant for HCC. Patients and methodology: transplant patients for HCC from 1989 to November 2003. Patients were selected due to general limitations of nodule size and quantity, which were subsequently published as Milan criteria. Also, criteria agreed in the Conference of Barcelona were followed in the pre-transplant diagnosis. Results: the survival of this 81 patients group was of the 80, 61 and 52% for 1, 5 and 10 years respectively. In the 32% of the cases the HCC was an incidental finding in the explant. In the 12.3%, the tumor relapse was verified. The multivariate research identified the size of the nodule (OR = 1,7944) (IC 95% = 1,1332-2,8413) and the vascular invasion (OR = 6,6346) (IC 95% = 1,4624-30,1003) as risk factors of relapse. Conclusions: the liver transplant in selected patients with HCC has good results in medium and long term. The risk of post-transplant tumor relapse becomes notably reduced and is associated with the size of the nodule and the microscopic vascular invasion.

Published
2006

26. Infección fúngica invasiva mixta por Rhizomucor pusillusy Aspergillus nigeren un paciente inmunocompetente

Author

Pozo-Laderas, Juan Carlos, Pontes-Moreno, Antonio, Robles-Arista, Juan Carlos, Bautista-Rodriguez, M. Dolores, Candau-Alvarez, Alberto, Caro-Cuenca, Maria Teresa, and Linares-Sicilia, María José

Abstract

Las mucormicosis son infecciones poco frecuentes en pacientes inmunocompetentes, y se han descrito muy pocos casos de mucormicosis asociadas a aspergilosis en pacientes no hematológicos.

Published
2015
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27. Papel de daptomicina en el tratamiento empírico y dirigido de infecciones por cocos grampositivos del paciente crítico.

Author

Garnacho-Montero, José, Amaya-Villar, Rosario, Gómez-Grande, Ma Luisa, Gómez-Coronado, Vicente Jerez, Lorente-Ramos, Leonardo, Vázquez, Ana Loza, Pellús, Antonio Martínez, Pozo Laderas, Juan Carlos, Camerino, Rafael Sierra, Mora, José Pomares, de la Torre Prados, Ma Victoria, and Leyba, Carlos Ortiz

Subjects
ANTIBIOTICS, GRAM-positive bacteria, CRITICALLY ill, MORTALITY, METHICILLIN-resistant staphylococcus aureus, VANCOMYCIN, EMPIRICAL research
Abstract

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2011

28. Prognostic implications of comorbidity patterns in critically ill COVID-19 patients: A multicenter, observational study.

Author

Benítez ID, de Batlle J, Torres G, González J, de Gonzalo-Calvo D, Targa ADS, Gort-Paniello C, Moncusí-Moix A, Ceccato A, Fernández-Barat L, Ferrer R, Garcia-Gasulla D, Menéndez R, Motos A, Peñuelas O, Riera J, Bermejo-Martin JF, Peñasco Y, Ricart P, Martin Delgado MC, Aguilera L, Rodríguez A, Boado Varela MV, Suarez-Sipmann F, Pozo-Laderas JC, Solé-Violan J, Nieto M, Novo MA, Barberán J, Amaya Villar R, Garnacho-Montero J, García-Garmendia JL, Gómez JM, Lorente JÁ, Blandino Ortiz A, Tamayo Lomas L, López-Ramos E, Úbeda A, Catalán-González M, Sánchez-Miralles A, Martínez Varela I, Jorge García RN, Franco N, Gumucio-Sanguino VD, Huerta Garcia A, Bustamante-Munguira E, Valdivia LJ, Caballero J, Gallego E, Martínez de la Gándara A, Castellanos-Ortega Á, Trenado J, Marin-Corral J, Albaiceta GM, de la Torre MDC, Loza-Vázquez A, Vidal P, Lopez Messa J, Añón JM, Carbajales Pérez C, Sagredo V, Bofill N, Carbonell N, Socias L, Barberà C, Estella A, Valledor Mendez M, Diaz E, López Lago A, Torres A, and Barbé F

Abstract

Background: The clinical heterogeneity of COVID-19 suggests the existence of different phenotypes with prognostic implications. We aimed to analyze comorbidity patterns in critically ill COVID-19 patients and assess their impact on in-hospital outcomes, response to treatment and sequelae., Methods: Multicenter prospective/retrospective observational study in intensive care units of 55 Spanish hospitals. 5866 PCR-confirmed COVID-19 patients had comorbidities recorded at hospital admission; clinical and biological parameters, in-hospital procedures and complications throughout the stay; and, clinical complications, persistent symptoms and sequelae at 3 and 6 months., Findings: Latent class analysis identified 3 phenotypes using training and test subcohorts: low-morbidity (n=3385; 58%), younger and with few comorbidities; high-morbidity (n=2074; 35%), with high comorbid burden; and renal-morbidity (n=407; 7%), with chronic kidney disease (CKD), high comorbidity burden and the worst oxygenation profile. Renal-morbidity and high-morbidity had more in-hospital complications and higher mortality risk than low-morbidity (adjusted HR (95% CI): 1.57 (1.34-1.84) and 1.16 (1.05-1.28), respectively). Corticosteroids, but not tocilizumab, were associated with lower mortality risk (HR (95% CI) 0.76 (0.63-0.93)), especially in renal-morbidity and high-morbidity. Renal-morbidity and high-morbidity showed the worst lung function throughout the follow-up, with renal-morbidity having the highest risk of infectious complications (6%), emergency visits (29%) or hospital readmissions (14%) at 6 months (p<0.01)., Interpretation: Comorbidity-based phenotypes were identified and associated with different expression of in-hospital complications, mortality, treatment response, and sequelae, with CKD playing a major role. This could help clinicians in day-to-day decision making including the management of post-discharge COVID-19 sequelae., Funding: ISCIII, UNESPA, CIBERES, FEDER, ESF., Competing Interests: None declared., (© 2022 The Author(s).)

Published
2022
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29. Deploying unsupervised clustering analysis to derive clinical phenotypes and risk factors associated with mortality risk in 2022 critically ill patients with COVID-19 in Spain.

Author

Rodríguez A, Ruiz-Botella M, Martín-Loeches I, Jimenez Herrera M, Solé-Violan J, Gómez J, Bodí M, Trefler S, Papiol E, Díaz E, Suberviola B, Vallverdu M, Mayor-Vázquez E, Albaya Moreno A, Canabal Berlanga A, Sánchez M, Del Valle Ortíz M, Ballesteros JC, Martín Iglesias L, Marín-Corral J, López Ramos E, Hidalgo Valverde V, Vidaur Tello LV, Sancho Chinesta S, Gonzáles de Molina FJ, Herrero García S, Sena Pérez CC, Pozo Laderas JC, Rodríguez García R, Estella A, and Ferrer R

Subjects
Aged, Cluster Analysis, Critical Illness, Female, Humans, Male, Middle Aged, Phenotype, Risk Assessment, Risk Factors, Spain epidemiology, COVID-19 mortality, COVID-19 therapy
Abstract

Background: The identification of factors associated with Intensive Care Unit (ICU) mortality and derived clinical phenotypes in COVID-19 patients could help for a more tailored approach to clinical decision-making that improves prognostic outcomes., Methods: Prospective, multicenter, observational study of critically ill patients with confirmed COVID-19 disease and acute respiratory failure admitted from 63 ICUs in Spain. The objective was to utilize an unsupervised clustering analysis to derive clinical COVID-19 phenotypes and to analyze patient's factors associated with mortality risk. Patient features including demographics and clinical data at ICU admission were analyzed. Generalized linear models were used to determine ICU morality risk factors. The prognostic models were validated and their performance was measured using accuracy test, sensitivity, specificity and ROC curves., Results: The database included a total of 2022 patients (mean age 64 [IQR 5-71] years, 1423 (70.4%) male, median APACHE II score (13 [IQR 10-17]) and SOFA score (5 [IQR 3-7]) points. The ICU mortality rate was 32.6%. Of the 3 derived phenotypes, the A (mild) phenotype (537; 26.7%) included older age (< 65 years), fewer abnormal laboratory values and less development of complications, B (moderate) phenotype (623, 30.8%) had similar characteristics of A phenotype but were more likely to present shock. The C (severe) phenotype was the most common (857; 42.5%) and was characterized by the interplay of older age (> 65 years), high severity of illness and a higher likelihood of development shock. Crude ICU mortality was 20.3%, 25% and 45.4% for A, B and C phenotype respectively. The ICU mortality risk factors and model performance differed between whole population and phenotype classifications., Conclusion: The presented machine learning model identified three clinical phenotypes that significantly correlated with host-response patterns and ICU mortality. Different risk factors across the whole population and clinical phenotypes were observed which may limit the application of a "one-size-fits-all" model in practice.

Published
2021
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30. [Disseminated mucormycosis in immunocompetent patients: A disease that also exists].

Author

Pozo Laderas JC, Pontes Moreno A, Pozo Salido C, Robles Arista JC, and Linares Sicilia MJ

Subjects
Agricultural Workers' Diseases microbiology, Antifungal Agents therapeutic use, Combined Modality Therapy, Dermatomycoses microbiology, Dermatomycoses therapy, Fungi classification, Humans, Incidence, Mucormycosis diagnosis, Mucormycosis therapy, Opportunistic Infections immunology, Opportunistic Infections therapy, Respiratory Tract Infections microbiology, Risk Factors, Soil Microbiology, Fungemia immunology, Immunocompetence, Mucormycosis immunology
Abstract

Mucormycosis is usually an acute angioinvasive infections, which leads to non-suppurative necrosis and significant tissue damage. It represents 1.6% of all the invasive fungal infections and predominates in immunosuppressed patients with risk factors. Incidence has been significantly increased even in immunocompetent patients. Due to finding a case of disseminated mucormycosis caused by Rhizomucor pusillus in a young immunocompetent patient, a systematic review was carried out of reported cases in PubMed of mucormycosis in immunocompetent adults according to the main anatomic locations, and especially in disseminated cases. A review of the main risk factors and pathogenicity, clinical manifestations, techniques of early diagnosis, current treatment options, and prognosis is presented. Taxonomy and classification of the genus Mucor has also been reviewed., (Copyright © 2013 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.)

Published
2015
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31. [Mixed invasive fungal infection due to Rhizomucor pusillus and Aspergillus niger in an immunocompetent patient].

Author

Pozo-Laderas JC, Pontes-Moreno A, Robles-Arista JC, Bautista-Rodriguez MD, Candau-Alvarez A, Caro-Cuenca MT, and Linares-Sicilia MJ

Subjects
Accidents, Traffic, Adolescent, Akinetic Mutism etiology, Amphotericin B therapeutic use, Anti-Bacterial Agents therapeutic use, Antifungal Agents therapeutic use, Aspergillosis drug therapy, Aspergillosis microbiology, Coinfection drug therapy, Coinfection microbiology, Combined Modality Therapy, Craniocerebral Trauma surgery, Critical Care methods, Gastrointestinal Diseases etiology, Gastrointestinal Diseases surgery, Humans, Lung Diseases, Fungal complications, Lung Diseases, Fungal drug therapy, Lung Diseases, Fungal microbiology, Lung Diseases, Fungal surgery, Male, Mucormycosis drug therapy, Mucormycosis microbiology, Postoperative Complications microbiology, Skull Fractures etiology, Skull Fractures surgery, Ulcer etiology, Ulcer surgery, Aspergillosis complications, Aspergillus niger isolation & purification, Craniocerebral Trauma complications, Immunocompetence, Mucormycosis complications, Rhizomucor isolation & purification, Wound Infection microbiology
Abstract

Background: Mucormycosis infections are rare in immunocompetent patients, and very few cases of mucormycosis associated with aspergillosis in non-haematological patients have been reported., Case Report: A 17-year-old male, immunocompetent and without any previously known risk factors, was admitted to hospital due to a seizure episode 11 days after a motorcycle accident. He had a complicated clinical course as he had a mixed invasive fungal infection with pulmonary involvement due to Aspergillus niger and disseminated mucormycosis due to Rhizomucor pusillus (histopathological and microbiological diagnosis in several non-contiguous sites). He was treated with liposomal amphotericin B for 7 weeks (total cumulative dose >10 g) and required several surgical operations. The patient survived and was discharged from ICU after 5 months and multiple complications., Conclusions: Treatment with liposomal amphotericin B and aggressive surgical management achieved the eradication of a mixed invasive fungal infection. However, we emphasise the need to maintain a higher level of clinical suspicion and to perform microbiological techniques for early diagnosis of invasive fungal infections in non-immunocompromised patients, in order to prevent spread of the disease and the poor prognosis associated with it., (Copyright © 2013 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.)

Published
2015
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32. [Antifungal prophylaxis in HIV-seropositive liver transplant recipients].

Author

Pozo Laderas JC

Subjects
HIV Seropositivity complications, Humans, Liver Neoplasms complications, Liver Neoplasms surgery, Male, Middle Aged, Antifungal Agents therapeutic use, Liver Transplantation, Mycoses prevention & control, Postoperative Complications prevention & control
Abstract

Background: Seropositive human immunodeficiency virus (HIV) patients have a high prevalence of chronic liver disease for which liver transplantation is the only possible treatment. Risk of fungal infection in this population may be very high., Case Report: We describe the clinical course of the early postoperative period in a patient coinfected with HIV and hepatitis C virus undergoing liver transplantation. We discuss antifungal prophylaxis indications and drugs of choice in relation to their efficacy and safety profile. Other medical treatments are described, as well as possible pharmacokinetic interactions., Conclusions: Antifungal prophylaxis with anidulafungin has proven effective and has presented no significant adverse effects on a patient at high risk of fungal infection and multiple risk factors for drug interactions., (Copyright © 2011 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.)

Published
2011
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33. [Invasive candidiasis in liver transplant recipient: early rescue antifungal treatment].

Author

Pozo-Laderas JC and Pontes-Moreno A

Subjects
Acute Kidney Injury complications, Acute Kidney Injury therapy, Adult, Anidulafungin, Antifungal Agents administration & dosage, Bacteremia etiology, Blood Loss, Surgical, Candidemia diagnosis, Candidemia drug therapy, Cross Infection diagnosis, Cross Infection drug therapy, Cross Infection microbiology, Early Diagnosis, Echinocandins administration & dosage, Hepatitis C, Chronic complications, Hepatitis C, Chronic surgery, Humans, Immunocompromised Host, Liver Cirrhosis, Alcoholic complications, Liver Cirrhosis, Alcoholic surgery, Male, Methicillin-Resistant Staphylococcus aureus isolation & purification, Opportunistic Infections diagnosis, Opportunistic Infections drug therapy, Opportunistic Infections microbiology, Postoperative Complications diagnosis, Postoperative Complications drug therapy, Postoperative Complications microbiology, Renal Dialysis, Reoperation, Risk, Staphylococcal Infections etiology, Antifungal Agents therapeutic use, Candidemia etiology, Cross Infection etiology, Echinocandins therapeutic use, Liver Transplantation, Opportunistic Infections etiology, Postoperative Complications etiology
Abstract

Background: Some liver transplant recipients could be at risk for candidemia or invasive candidiasis during the immediate postoperative period after transplantation. Prophylaxis is the best strategy to reduce the incidence of invasive fungal infection caused by Candida species in high-risk liver transplant recipients (HR-LTR), but in cases of suspected breakthrough invasive fungal infection due to Candida, both a rapid diagnosis process and early antifungal treatment are the most important factors impacting on the prognosis., Clinical Case: We report a case of early rescue treatment with anidulafungin in a HR-LTR with complicated postoperative course. We discuss risk factors, prophylaxis, sensitivity of biomarkers, and characteristics of antifungal management., Conclusions: Early rescue antifungal treatment using candins improves the prognosis in HR-LTR suffering from invasive candidiasis., (Copyright © 2011 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.)

Published
2011
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34. [Clinical use of micafungin for the treatment of invasive candidiasis in critical ill patients].

Author

Pozo-Laderas JC

Subjects
Antifungal Agents administration & dosage, Antifungal Agents adverse effects, Candidiasis epidemiology, Caspofungin, Clinical Trials as Topic statistics & numerical data, Critical Care, Drug Therapy, Combination, Echinocandins administration & dosage, Echinocandins adverse effects, Humans, Incidence, Leukocyte Count, Lipopeptides administration & dosage, Lipopeptides adverse effects, Micafungin, Neutrophils, Randomized Controlled Trials as Topic statistics & numerical data, Antifungal Agents therapeutic use, Candidiasis drug therapy, Critical Illness, Echinocandins therapeutic use, Fungemia drug therapy, Lipopeptides therapeutic use
Abstract

Background: Over the last 30 years a significant increase of Candida spp. invasive disease has been observed in non-neutropenic critical ill patients. Both fluconazole and amphotericin B have been considered first line treatment for invasive (proven and probable) Candida spp. disease, although the mortality rate is still high., Objectives: To review the current data on the use of micafungin for the treatment of Candida invasive disease in critical ill patients., Methods: The pharmacologic, mycological and clinical properties of micafungin are reviewed based on current published data. The use and efficacy of micafungin for the treatment of Candida invasive disease in critical ill patients is discussed., Results and Conclusions: To reduce the rate of mortality more effective antifungals and pre-emptive treatment strategies are currently warranted. Candins achieve better results for the treatment of invasive Candida disease in non-neutropenic critical ill patients. Micafungin has a good safety profile (similar to fluconazole). Micafungin is a first line drug for the treatment of invasive Candida disease and may be used as a pre- emptive approach followed by a de-escalating strategy with azoles.

Published
2009
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