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Introduction. Hypovitaminosis is currently common among various social groups. The present research offers a new medical formulation that includes a complex of antioxidant vitamins with a highly beneficial synergistic effect. Study objects and methods. The research employed the SF-36 questionnaire to assess the quality of life in patients with chronic diseases, as recommended by the WHO. The SF-36 questionnaire provides a quantitative description of the physical, emotional, and social components of the quality of life. Clinical control was performed on days 31–32 from the onset of the medication. The state of the microcirculatory bed was assessed in laboratory conditions by applying pressure to the nail bed. The concentration of malondialdehyde was determined by the method developed by M. Uchiyama and M. Mihara. Results and discussion. The paper introduces the formulation and describes the properties of each component. The efficacy of the medicine was confirmed experimentally. Twenty education and health workers were administered the medicine for one month. The control group consisted of fifteen volunteers, who were randomized and grouped according to professional factor, sex, and age. The control group consumed the medicine together with standard vitamins A, C, and E in adequate dosages. Conclusion. The developed medicine proved able to improve the physical, social, and emotional aspects of life quality under high psychophysical stress. The polyvalent effect of the components demonstrated a tropism to collagen synthesis. In addition, it showed an antioxidant effect and improved microcirculation. The medicine can be used preventively to reduce the risk of chronic pathology based on the accumulation of excess free radical activity.

Biologically active complex on plant materials is part of a specialized product which due to some antioxidant properties helps to slow down the occurrence of age-related changes in the body.The technology of this specialized product in the encapsulated form of a biologically active additive (BAA) has been developed. The main stages of production include: preparation of raw materials and examination of accompanying documents, weighing and dosing of raw materials; sieving, grinding and resieving; mixing and quality control; encapsulation and dusting; packaging, labeling and storage. The hygienic safety of the product has been proved by examining microbiological indicators – yeast and mold, E. Coli, KMAFАnM, pathogenic microorganisms, including salmonella, coliforms (BHCP), toxic metals, pesticide. The content of toxic metals and pesticides has been studied. All indicators are within the requirements of the current regulatory documents. Sparing modes of production parameters, storage at the temperature not exceeding 25 °C and a slight moisture content in the product (3–5 %) guarantee the stability of the biologically active components of the formulation and high consumer properties. Regulated quality indicators are established, including nutritional value in 1 capsule, mg: ascorbic acid content – 30; vitamin E – 10; beta-carotene – 2. The inclusion in the diet of two capsules (recommended daily amount) guarantees the intake, mg: vitamin C (ascorbic acid) – 60 (67); vitamin E – 20 (67); beta carotene – 4 (80). In brackets – % of daily need. The functional orientation of dietary supplements based on the pharmacological characteristics of the prescription ingredients has been considered. The product is positioned as a specialized antioxidant complex to protect the body from the effects of free radicals and increase the functional activity of the immune system. The effectiveness of dietary supplements is based on the synergistic properties of biologically active substances of the peach leaf extract.

The development of new functional foods that contribute to the preservation and improvement of human health is one of the priorities in the food industry. In this regard, the production and sales of sugar confectionery products with low energy value and various enriching additives are gradually increasing, including those meant for diabetic therapeutic and dietary preventive nutrition. At the same time, the share of these products remains insignificant. The research prospective was to develop a technology for the production of marshmallow, which reduces the risk of obesity and type II diabetes. The study featured three samples of marshmallow: with granulated sugar, fructose, and inulin. The research determined the functional properties of the finished product. Three female volunteers (21, 32, and 45 years old) participated in the experiment. It was established that the replacement of granulated sugar with a natural sweetener, namely fructose and a mixture of fructose and inulin, led to a decrease in the body’s hyperglycemic response half an hour after consuming the analyzed sample, and resulted in a smooth sugar curve. Thus, natural additives and biologically active substances make sugar confectionery products functional, which is a priority for the development of the confectionery industry.

A case of successful surgical treatment of extragenital endometriosis Dresvyanskaya T. V.1, Prusov I. A.1, Fokina A. P.1, Bichurin R. A.1, 2, Nadich V. E.1, Pozdnyakova O. F.1, Oshueva S. V.1, Nikitenko I. A.1, Safronova N. I.1, Serova E. V.1, 2 1Krasnoyarsk Interdistrict Clinical Hospital № 4 2Krasnoyarsk State Medical University named after Prof. V. F. Voyno-Yasenetskiy Extragenital endometriosis (EGE) is the most rare variant of endometriosis, characterized by the proliferation of tissue that is similar in morphology and function to the endometrium, in organs and tissues that are not related to the reproductive system. The frequency of EGE is 6–8% of all cases of endometriosis. The frequency of detection of endometriosis is increasing in recent years. The cases described in the publications are non-standard, manifestations of the disease are erased or similar to other diseases. Patients with EGE are often treated in non-specialized departments, which leads to the errors in the tactics of treatment. The correct diagnosis is often established during the operation and is confirmed by the results of histological examination, and treatment often requires the involvement of specialists from other areas. In this article, there is a case of successful surgical treatment of EGE of rare localization. In the surgical treatment of endometriosis, as well as in other surgical interventions associated with the opening of the uterine cavity (for example, caesarean section), a specialist should be aware of the possibility of implantation of endometrioid heterotopies and avoid contact of the endometrium or tissues of endometriosis with the peritoneum and operating wound. Key words: extragenital endometriosis, surgical treatment, endometrium, implantation theory. For citation: Dresvyanskaya T.V., Prusov I.A., Fokina A.P. et al. A case of successful surgical treatment of extragenital endometriosis // RMJ. 2018. № 2(I). P. 70–72.

Purpose. To identify environmental climatic impacts resulting from the biodiesel fuel use for vehicles (Vs). Methodology. The methods are based on computation of natural resource consumption and toxic emission with the help of environmental footprint calculator being a software program. Findings. The results of integral assessment of the environmental impact (namely, consumption of water, power, natural resources, and emission of greenhouse gases СО2, and NOx in terms of such base traction trucks as VOLVO FM, FH, FE, and FL) were computed for biodiesel fuel types В0, В7, В30, В100 depending upon different standards of EURO propellants. Both positive and negative environmental impact factors have been determined for consuming biofuels during full lifecycle of Vs. It has been defined that minor decrease in СО2 emission owing to the use of standard modern biodiesel fuel is followed by significant increase in NOx emission as well as power and water consumption in terms of first-generation biodiesel fuel utilization. VOLVO FЕ Vs were applied for comparative analysis of environmental impact by first-generation biodiesel fuel (i. e. В7, В30, В100) and second-generation fuel being hydrotreated vegetable oil (HVO). Similar tendencies were recognized. Moreover, opportunity to apply biodiesel fuels along with other measures decreasing СО2 emission was analyzed. Originality. Originality is stipulated by the use of the integrated assessment of impact of vehicles on climate change as well as use of natural resources while applying biodiesel fuel for vehicles. Practical value. It is possible to forecast environmental consequences resulting from the use of various biodiesel fuels for Vs. [ABSTRACT FROM AUTHOR]