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8. The NHLBI Study on Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC): Design and Objectives

Author

Truong, Dongngan T, Trachtenberg, Felicia L, Pearson, Gail D, Dionne, Audrey, Elias, Matthew D, Friedman, Kevin, Hayes, Kerri H, Mahony, Lynn, McCrindle, Brian W, Oster, Matthew E, Pemberton, Victoria, Powell, Andrew J, Russell, Mark W, Shekerdemian, Lara S, Son, Mary Beth, Taylor, Michael, Newburger, Jane W, Investigators, for the MUSIC Study, Giglia, Therese M, McHugh, Kimberly E, Atz, Andrew M, Pletzer, Scott A, Lang, Sean M, Payne, R Mark, Patel, Jyoti K, Pignatelli, Ricardo H, Sexson, Kristen, Lam, Christopher, Dragulescu, Andreea, Young, Rae SM, Gamulka, Beth, Krishnan, Anita, Anderson, Brett R, Farooqi, Kanwal M, Shakti, Divya, Parnell, Aimee S, Osakwe, Onyekachukwu J, Sykes, Michelle C, Morgan, Lerraughn, Owada, Carl Y, Forsha, Daniel, Carr, Michael R, Watanabe, Kae, Portman, Michael A, Dummer, Kristen B, Burns, Jane C, Tremoulet, Adriana H, Sharma, Kavita, Jone, Pei-Ni, Heizer, Michelle Hite Heather, Hasbani, Keren, Srivastava, Shubhika, Mitchell, Elizabeth C, Hebson, Camden L, Szmuszkovicz, Jacqueline R, Wong, Pierre C, Cheng, Andrew L, Votava-Smith, Jodie K, Wang, Shuo, Mohandas, Sindhu, Singh, Gautam K, Aggarwal, Sanjeev, Sanil, Yamuna, Bradford, Tamara T, Muniz, Juan Carlos G, Li, Jennifer S, Campbell, Michael Jay, Handler, Stephanie S, Shea, J Ryan, Hoffman, Timothy M, Franklin, Wayne J, Sabati, Arash A, Nowlen, Todd T, and Chrisant, Maryanne

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Heart Disease, Biomedical Imaging, Clinical Trials and Supportive Activities, Cardiovascular, Clinical Research, Prevention, Pediatric, Patient Safety, Adult, COVID-19, Child, Heart, Humans, Magnetic Resonance Imaging, National Heart, Lung, and Blood Institute (U.S.), SARS-CoV-2, Stroke Volume, Systemic Inflammatory Response Syndrome, United States, Ventricular Function, Left, Young Adult, MUSIC Study Investigators, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundThe Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC) study aims to characterize the frequency and time course of acute and long-term cardiac and non-cardiac sequelae in multisystem inflammatory syndrome in children associated with COVID-19 (MIS-C), which are currently poorly understood.MethodsThis multicenter observational cohort study will enroll at least 600 patients

Published
2022

10. Contributors

Author

Abrams, Dominic J., primary, Alexander, Mark E., additional, Alexander, Peta M.A., additional, Allan, Catherine, additional, Baird, Christopher W., additional, Bergersen, Lisa, additional, Beroukhim, Rebecca, additional, Bevilacqua, Laura M., additional, Bezzerides, Vassilios, additional, Blume, Elizabeth D., additional, Breitbart, Roger E., additional, Brown, David W., additional, Callahan, Ryan, additional, Carreon, Chrystalle Katte, additional, Castellanos, Daniel A., additional, Chen, Ming Hui, additional, Cheng, Henry, additional, Colan, Steven D., additional, Daly, Kevin P., additional, de Ferranti, Sarah D., additional, del Nido, Pedro J., additional, DeWitt, Elizabeth, additional, DiNardo, James, additional, Dionne, Audrey, additional, Emani, Sitaram M., additional, Esch, Jesse J., additional, Esteso, Paul, additional, Feins, Eric N., additional, Freed, Michael D., additional, Friedman, Kevin, additional, Fulton, David R., additional, Fynn-Thompson, Francis, additional, Garbern, Jessica C., additional, Garcia-Mancebo, Julia, additional, Gauthier, Naomi, additional, Geggel, Robert L., additional, Geisser, Diana L., additional, Gellis, Laura, additional, Geva, Tal, additional, Ghbeis, Muhammad Bakr, additional, Ghelani, Sunil J., additional, Goldberg, Sarah W., additional, Gurvitz, Michelle, additional, Hames, Daniel L., additional, Harrild, David M., additional, Hartz, Jacob, additional, Hickey, Patricia, additional, Hoganson, David, additional, Jenkins, Kathy, additional, Kane, David, additional, Kaza, Aditya K., additional, Kheir, John N., additional, Kumar, R. Krishna, additional, Kwon, Michael H., additional, Lacro, Ronald V., additional, Landzberg, Michael J., additional, Lang, Peter, additional, LaRovere, Joan M., additional, Levine, Jami, additional, Lock, James Ernest, additional, Lyon, Shannon, additional, Mah, Douglas Y., additional, Marx, Gerald R., additional, Maschietto, Nicola, additional, Matte, Gregory S., additional, Mayer, John E., additional, Mills, Kimberly I., additional, Mistry, Kshitij, additional, Mullen, Mary P., additional, Nasr, Viviane G., additional, Nathan, Meena, additional, Newburger, Jane W., additional, O’Brien, Patricia, additional, O’Brien, Sharon E., additional, O’Leary, Edward T., additional, Porras, Diego, additional, Powell, Andrew J., additional, Prakash, Ashwin, additional, Pu, William T., additional, Quiat, Daniel, additional, Quinn, Brian, additional, Quinonez, Luis, additional, Rathod, Rahul H., additional, Rhodes, Jonathan, additional, Roberts, Amy E., additional, Rodriguez-Monserrate, Carla P., additional, Ronai, Christina, additional, Saia, Theresa, additional, Saleeb, Susan F., additional, Salvin, Joshua W., additional, Sanders, Stephen P., additional, Schidlow, David, additional, Shafer, Keri M., additional, Siegel, Bryan D., additional, Singh, Michael N., additional, Singh, Tajinder, additional, Teele, Sarah A., additional, Thiagarajan, Ravi R., additional, Triedman, John K., additional, Tworetzky, Wayne, additional, Valente, Anne Marie, additional, VanderPluym, Christina, additional, Walsh, Edward P., additional, Wu, Fred Ming-Chieh, additional, and Yin, Suellen, additional

Published
2025
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13. Design and implementation of multicenter pediatric and congenital studies with cardiovascular magnetic resonance: Big data in smaller bodies

Author

DiLorenzo, Michael P., Lee, Simon, Rathod, Rahul H., Raimondi, Francesca, Farooqi, Kanwal M., Jain, Supriya S., Samyn, Margaret M., Johnson, Tiffanie R., Olivieri, Laura J., Fogel, Mark A., Lai, Wyman W., Renella, Pierangelo, Powell, Andrew J., Buddhe, Sujatha, Stafford, Caitlin, Johnson, Jason N., Helbing, Willem A., Pushparajah, Kuberan, Voges, Inga, Muthurangu, Vivek, Miles, Kimberley G., Greil, Gerald, McMahon, Colin J., Slesnick, Timothy C., Fonseca, Brian M., Morris, Shaine A., Soslow, Jonathan H., Grosse-Wortmann, Lars, Beroukhim, Rebecca S., and Grotenhuis, Heynric B.

Published
2024
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15. Society for Cardiovascular Magnetic Resonance (SCMR) guidance for re-activation of cardiovascular magnetic resonance practice after peak phase of the COVID-19 pandemic

Author

Allen, Bradley D, Wong, Timothy C, Bucciarelli-Ducci, Chiara, Bryant, Jennifer, Chen, Tiffany, Dall’Armellina, Erica, Finn, J Paul, Fontana, Marianna, Francone, Marco, Han, Yuchi, Hays, Allison G, Jacob, Ron, Lawton, Chris, Manning, Warren J, Ordovas, Karen, Parwani, Purvi, Plein, Sven, Powell, Andrew J, Raman, Subha V, Salerno, Michael, and Carr, James C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Patient Safety, Cardiovascular, Clinical Research, Biomedical Imaging, Good Health and Well Being, Betacoronavirus, COVID-19, Cardiovascular Diseases, Cardiovascular System, Coronavirus Infections, Humans, Magnetic Resonance Imaging, Pandemics, Pneumonia, Viral, Practice Guidelines as Topic, Predictive Value of Tests, SARS-CoV-2, Societies, Medical, Cardiovascular magnetic resonance, Workflow, Safety, Cardiovascular magnetic resonance , Cardiorespiratory Medicine and Haematology, Nuclear Medicine & Medical Imaging, Cardiovascular medicine and haematology
Abstract

During the peak phase of the COVID-19 pandemic, alterations of standard operating procedures were necessary for health systems to protect patients and healthcare workers and ensure access to vital hospital resources. As the peak phase passes, re-activation plans are required to safely manage increasing clinical volumes. In the context of cardiovascular magnetic resonance (CMR), re-activation objectives include continued performance of urgent CMR studies and resumption of CMR in patients with semi-urgent and elective indications in an environment that is safe for both patients and health care workers.

Published
2020

16. Appropriateness of cardiovascular computed tomography and magnetic resonance imaging in patients with conotruncal defects

Author

Pickard, Sarah S., Armstrong, Aimee K., Balasubramanian, Sowmya, Buddhe, Sujatha, Crum, Kimberly, Kong, Grace, Lang, Sean M., Lee, Marc V., Lopez, Leo, Natarajan, Shobha S., Norris, Mark D., Parra, David A., Parthiban, Anitha, Powell, Andrew J., Priromprintr, Bryant, Rogers, Lindsay S., Sachdeva, Shagun, Shah, Sanket S., Smith, Clayton A., Stern, Kenan W.D., Xiang, Yijin, Young, Luciana T., and Sachdeva, Ritu

Published
2023
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17. Iterative Segmentation from Limited Training Data: Applications to Congenital Heart Disease

Author

Pace, Danielle F., Dalca, Adrian V., Brosch, Tom, Geva, Tal, Powell, Andrew J., Weese, Jürgen, Moghari, Mehdi H., and Golland, Polina

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

We propose a new iterative segmentation model which can be accurately learned from a small dataset. A common approach is to train a model to directly segment an image, requiring a large collection of manually annotated images to capture the anatomical variability in a cohort. In contrast, we develop a segmentation model that recursively evolves a segmentation in several steps, and implement it as a recurrent neural network. We learn model parameters by optimizing the interme- diate steps of the evolution in addition to the final segmentation. To this end, we train our segmentation propagation model by presenting incom- plete and/or inaccurate input segmentations paired with a recommended next step. Our work aims to alleviate challenges in segmenting heart structures from cardiac MRI for patients with congenital heart disease (CHD), which encompasses a range of morphological deformations and topological changes. We demonstrate the advantages of this approach on a dataset of 20 images from CHD patients, learning a model that accurately segments individual heart chambers and great vessels. Com- pared to direct segmentation, the iterative method yields more accurate segmentation for patients with the most severe CHD malformations., Comment: Presented at the Deep Learning in Medical Image Analysis Workshop, MICCAI 2018

Published
2018

23. The NHLBI Study on Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC): Design and Objectives

Author

Dionne, Audrey, Elias, Matthew D., Giglia, Therese M., McHugh, Kimberly E., Atz, Andrew M., Pletzer, Scott A., Truong, Dongngan T., Russell, Mark W., Lang, Sean M., Payne, R. Mark, Patel, Jyoti K., Oster, Matthew E., Shekerdemian, Lara S., Pignatelli, Ricardo H., Sexson, Kristen, McCrindle, Brian W., Lam, Christopher, Dragulescu, Andreea, Young, Rae SM, Gamulka, Beth, Krishnan, Anita, Anderson, Brett R., Farooqi, Kanwal M., Shakti, Divya, Parnell, Aimee S., Osakwe, Onyekachukwu J, Sykes, Michelle C., Morgan, Lerraughn, Owada, Carl Y., Forsha, Daniel, Carr, Michael R., Watanabe, Kae, Portman, Michael A., Dummer, Kristen B., Burns, Jane C., Tremoulet, Adriana H., Sharma, Kavita, Jone, Pei-Ni, Heizer, Michelle Hite Heather, Hasbani, Keren, Srivastava, Shubhika, Mitchell, Elizabeth C, Hebson, Camden L., Szmuszkovicz, Jacqueline R., Wong, Pierre C., Cheng, Andrew L., Votava-Smith, Jodie K., Wang, Shuo, Mohandas, Sindhu, Singh, Gautam K., Aggarwal, Sanjeev, Sanil, Yamuna, Bradford, Tamara T., Muniz, Juan Carlos G., Li, Jennifer S., Campbell, Michael Jay, Handler, Stephanie S., Shea, J Ryan, Hoffman, Timothy M., Franklin, Wayne J., Sabati, Arash A., Nowlen, Todd T., Chrisant, Maryanne, Trachtenberg, Felicia L., Pearson, Gail D., Friedman, Kevin, Hayes, Kerri H., Mahony, Lynn, Pemberton, Victoria, Powell, Andrew J., Son, Mary Beth, Taylor, Michael, and Newburger, Jane W.

Published
2022
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26. Dirac vs Majorana gauginos at a 100 TeV collider

Author

di Cortona, Giovanni Grilli, Hardy, Edward, and Powell, Andrew J.

Subjects
High Energy Physics - Phenomenology
Abstract

We compare the prospects for observing theories with Majorana or Dirac gauginos at a future 100 TeV proton-proton collider. Calculating the expected discovery and exclusion regions, we find that for heavy gluino masses the squark discovery reach is significantly reduced in Dirac gluino models relative to the Majorana case. However, if the squark and gluino masses are close the reach is similar in both scenarios. We also consider the electroweak fine tuning of theories observable at such a collider, and the impact of existing constraints from flavour and CP violating observables. Models with Majorana gluinos that are fine tuned to less than one part in 10,000 can typically be discovered or excluded, and Dirac models with tuning of one part in 1,000 can be probed. The flavour structure of Majorana models is highly constrained if they have observable squarks, while O(1) violation is possible in accessible Dirac models. In both cases new sources of CP violation must be very suppressed. Future collider searches can also give important information on possible dark matter candidates. We study the relation of this to indirect and direct detection searches, and find that if dark matter is a neutralino, a 100 TeV collider could probe the viable dark matter candidates in large classes of both Dirac and Majorana models., Comment: 44 pages, 9 figures

Published
2016

27. Constraints on Axion-Like Particles from X-ray Observations of NGC1275

Author

Berg, Marcus, Conlon, Joseph P., Day, Francesca, Jennings, Nicholas, Krippendorf, Sven, Powell, Andrew J., and Rummel, Markus

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract

Axion-like particles (ALPs) can induce localised oscillatory modulations in the spectra of photon sources passing through astrophysical magnetic fields. Ultra-deep Chandra observations of the Perseus cluster contain over $5 \times 10^5$ counts from the AGN of the central cluster galaxy NGC1275, and represent a dataset of extraordinary quality for ALP searches. We use this dataset to search for X-ray spectral irregularities from the AGN. The absence of irregularities at the O(30%) level allows us to place leading constraints on the ALP-photon mixing parameter $g_{a\gamma\gamma} \lesssim 1.4 - 4.0 \times 10^{-12} {\rm GeV}^{-1}$ for $m_a \lesssim 10^{-12}$ eV, depending on assumptions on the magnetic field realisation along the line of sight., Comment: v1. 37 pages, 17 figures; v2. references added, additional discussion of gain and bounds; v3. final version accepted by ApJ

Published
2016
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30. Galaxy Cluster Thermal X-Ray Spectra Constrain Axion-Like Particles

Author

Conlon, Joseph P., Marsh, M. C. David, and Powell, Andrew J.

Subjects
High Energy Physics - Phenomenology, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Axion-like particles (ALPs) and photons inter-convert in the presence of a magnetic field. At keV energies in the environment of galaxy clusters, the conversion probability can become unsuppressed for light ALPs. Conversion of thermal X-ray photons into ALPs can introduce a step-like feature into the cluster thermal bremsstrahlung spectrum, and we argue that existing X-ray data on galaxy clusters should be sufficient to extend bounds on ALPs in the low-mass region $m_a \lesssim 1 \times 10^{-12}\,{\rm eV}$ down to $M \sim 7\times 10^{11}\, {\rm GeV}$, and that for $10^{11}\, {\rm GeV} < M \lesssim 10^{12}$ GeV light ALPs give rise to interesting and unique observational signatures that may be probed by existing and upcoming X-ray (and potentially X-ray polarisation) observations of galaxy clusters., Comment: 5 pages

Published
2015
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31. A Cosmic ALP Background and the Cluster Soft X-ray Excess in A665, A2199 and A2255

Author

Powell, Andrew J.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

It has been proposed that an excess in soft X-ray emission observed from many galaxy clusters can be explained by conversion into photons of axion-like particles (ALPs) in the cluster's magnetic field. Previously it has been shown that conversion of this primordially-generated background of relativistic ALPs---a cosmic ALP background (CAB)---can explain the observed soft X-ray excess in both the centre and the outskirts of the Coma cluster. Here we extend this work to the three clusters A665, A2199 and A2255. We use a stochastic model of the cluster magnetic field to numerically calculate ALP-photon conversion probabilities to predict the CAB-generated soft X-ray flux in these clusters. We compare this flux to ROSAT PSPC observations of the three clusters, and use these observations to constrain the CAB parameter space. We find the CAB can reproduce the magnitude of the observed excess in A2199 and A2255 for the same CAB parameters that match the observed soft excess in the Coma cluster. We also find good fit to the morphology of the excesses in these clusters. Simulation of CAB conversion in the cluster A665 is in mild tension with the other clusters due to producing a small but observable excess at large radii where none is observed. This tension is alleviated considering the uncertainty on predicting the count rate in the ROSAT detector, and on the systematics affecting the magnetic field determination. Overall we find good agreement between the CAB parameters for the four clusters studied so far., Comment: 25 pages, 13 figures

Published
2014
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35. Automated segmentation of 3D cine cardiovascular magnetic resonance imaging

Author

Tayebi Arasteh, Soroosh, primary, Romanowicz, Jennifer, additional, Pace, Danielle F., additional, Golland, Polina, additional, Powell, Andrew J., additional, Maier, Andreas K., additional, Truhn, Daniel, additional, Brosch, Tom, additional, Weese, Juergen, additional, Lotfinia, Mahshad, additional, van der Geest, Rob J., additional, and Moghari, Mehdi H., additional

Published
2023
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36. A 3.55 keV line from $\text{DM}\rightarrow a \rightarrow \gamma$: predictions for cool-core and non-cool-core clusters

Author

Conlon, Joseph P. and Powell, Andrew J.

Subjects
High Energy Physics - Phenomenology, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We further study a scenario in which a 3.55 keV X-ray line arises from decay of dark matter to an axion-like particle (ALP), that subsequently converts to a photon in astrophysical magnetic fields. We perform numerical simulations of Gaussian random magnetic fields with radial scaling of the magnetic field magnitude with the electron density, for both cool-core `Perseus' and non-cool-core `Coma' electron density profiles. Using these, we quantitatively study the resulting signal strength and morphology for cool-core and non-cool-core clusters. Our study includes the effects of fields of view that cover only the central part of the cluster, the effects of offset pointings on the radial decline of signal strength and the effects of dividing clusters into annuli. We find good agreement with current data and make predictions for future analyses and observations., Comment: 14 pages, 6 figures

Published
2014
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38. Loop corrections to Delta N_eff in large volume models

Author

Angus, Stephen, Conlon, Joseph P., Haisch, Ulrich, and Powell, Andrew J.

Subjects
High Energy Physics - Phenomenology, Astrophysics - Cosmology and Extragalactic Astrophysics, High Energy Physics - Theory
Abstract

In large volume models reheating is driven by the decays of the volume modulus to the visible sector, while the decays to its axion partners result in dark radiation. In this article we discuss the impact of loop corrections on the only model-independent visible decay channel: the decay into Higgs pairs via a Giudice-Masiero term. Including such radiative effects leads to a more precise determination of the relative fraction of dark radiation, since by contrast all loop corrections to the volume axion decay mode are Planck suppressed. Assuming an MSSM spectrum and that the Giudice-Masiero coupling is fixed at the string scale by a shift symmetry in the Higgs sector, we arrive at a prediction for the effective number of neutrinos. The result turns out to be too large to be consistent with data, highly disfavouring the minimal model., Comment: 14 pages, 3 figures; v2: Version to appear in JHEP. Expanded introduction to clarify arguments, assumptions and applicability of results; added references

Published
2013
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44. Aortic arch shape after arch repair predicts exercise capacity: a multicentre analysis.

Author

Mandell, Jason G, Romanowicz, Jennifer, Loke, Yue-Hin, Ikeda, Nobuyuki, Pena, Emily, Siddiqi, Umar, Hibino, Narutoshi, Alexander, Mark E, Powell, Andrew J, and Olivieri, Laura J

Subjects
AEROBIC capacity, THORACIC aorta, BLOOD pressure, CARDIAC magnetic resonance imaging, MITRAL valve
Abstract

Aims: Coarctation of the aorta is associated with long-term morbidity including decreased exercise capacity, despite successful repair. In the absence of discrete recoarctation, the haemodynamic mechanism remains unknown. This multicentre study evaluated the relationship between aorta shape, flow, and exercise capacity in patients after arch repair, specifically through the lens of aortic size mismatch and descending aortic (DAo) flow and their association with exercise. Methods and results: Cardiac magnetic resonance, cardiopulmonary exercise test, and echocardiogram data within 1 year were analysed from 58 patients (age 28 ± 10 years, 48% male) across four centres with history of isolated arch repair. Aortic arch measurements were correlated with % predicted VO2max with subgroup analyses of those with residual arch obstruction, bicuspid aortic valve, and hypertension. Ascending aorta (AAo) to DAo diameter ratio (DAAo/DDAo) was negatively correlated with % predicted VO2max. %DAo flow positively correlated with VO2max. Sub-analyses demonstrated that the negative correlation of DAAo/DDAo with VO2max was maintained only in patients without arch obstruction and with a bicuspid aortic valve. Smaller aortic arch measurements were associated with both hypertension and exercise-induced hypertension. Conclusion: Aorta size mismatch, due to AAo dilation or small DAo, and associated decreased %DAo flow, correlated significantly with decreased exercise capacity after aortic arch repair. These correlations were stronger in patients without arch obstruction and with a bicuspid aortic valve. Aorta size mismatch and %DAo flow capture multiple mechanisms of altered haemodynamics beyond blood pressure gradient or discrete obstruction and can inform the definition of a successful repair. Graphical Abstract Fifty-eight patients across four centres with a history of isolated arch repair were analysed. Ascending aorta (AAo) and descending aorta (DAo) diameter was measured from cardiac magnetic resonance, and the ratio (DAAo/DDAo) was calculated. Peak exercise capacity (% predicted VO2 max) ranged from severely decreased to normal. DAAo/DDAo negatively correlated with exercise capacity (% predicted VO2 max). Twenty-seven patients had sufficient data to calculate %DAo flow (DAo flow/AAo flow). %DAo flow positively correlated with % predicted VO2 max. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Right ventricular contraction patterns in healthy children using three-dimensional echocardiography

Author

Valle, Christopher, primary, Ujvari, Adrienn, additional, Elia, Eleni, additional, Lu, Minmin, additional, Gauthier, Naomi, additional, Hoganson, David, additional, Marx, Gerald, additional, Powell, Andrew J., additional, Ferraro, Alessandra, additional, Lakatos, Bálint, additional, Tősér, Zoltán, additional, Merkely, Béla, additional, Kovacs, Attila, additional, and Harrild, David M., additional

Published
2023
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