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549 results on '"Pourmadadi, Mehrab"'

15. Novel carboxymethyl cellulose based nanocomposite: A promising biomaterial for biomedical applications

Author

Pourmadadi, Mehrab, Rahmani, Erfan, Shamsabadipour, Amin, Samadi, Amirmasoud, Esmaeili, Javad, Arshad, Rabia, Rahdar, Abbas, Tavangarian, Fariborz, and Pandey, Sadanand

Subjects
Biochemistry and Cell Biology, Biological Sciences, Industrial Biotechnology, Biotechnology, Bioengineering, Biochemistry and cell biology, Industrial biotechnology
Abstract

The promising potential of biomaterials for biomedical applications has spurred conducting intensive studies in this field. Cellulose derivatives are biocompatible polymers with favorable physical and mechanical features. The distinctive properties of cellulose derivatives are gaining significant attention due to their potential for biomedical applications, including tissue engineering, wound dressing, and drug delivery. Carboxymethyl cellulose (CMC), the first and major cellulose derivative has been a promising cellulose-based compound since its development in 20th century. Water solubility, nontoxicity, biocompatibility, chemical stability, biodegradability with no side effects are among the unique attributes that have retained CMC's position as an attractive option for commercial applications, including the biomedical field. In this study, CMC properties and their potential for biomedical applications are discussed. Different methods to produce CMC hydrogels are reviewed. Extensive literature review has been added in terms of synthesis, and applications in biomedical fields. Various authors have demonstrated strong anti-bacterial, and anti-tumor application by elaborating different formulation strategies. This review highlights applications of CMC-based nanocomposites in tissue engineering, wound dressing, and drug delivery.

Published
2023

17. Properties and application of carbon quantum dots (CQDs) in biosensors for disease detection: A comprehensive review

Author

Pourmadadi, Mehrab, Rahmani, Erfan, Rajabzadeh-Khosroshahi, Maryam, Samadi, Amirmasoud, Behzadmehr, Razieh, Rahdar, Abbas, and Ferreira, Luiz Fernando Romanholo

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Nanotechnology, Bioengineering, Cancer, Carbon quantum dot, Diagnosis, Biosensor, Pharmacology & Pharmacy, Pharmacology and pharmaceutical sciences
Abstract

In the areas of bioimaging and detection, biosensors have attracted extensive attention recently. Specifically, biosensors based on nanostructures provide a more sensitive detection due to their prominent properties. Different biosensors have used quantum dots (QDs) due to their unique properties, like high quantum yield (QY) and photoluminescence. In addition to possessing the advantages of common QDs, carbon quantum dots (CQDs) have a higher solubility, lower toxicity, and easier synthesis, making them highly useful and a promising candidate for biomedical applications. The CQD is a zero-dimensional nanostructure with a size of less than 10 nm in every dimension. The unparallel features of CQDs, including good biocompatibility and unique optical properties, like high photoluminescence (PL) and Quantum yield (QY), make them attractive candidates for biosensor and bioimaging applications. This review examines the recent advances in biosensors based on CQDs and presents the properties, challenges, and future perspectives to pave the way for further studies in the future.

Published
2023

27. A comprehensive review of synthesis, structure, properties, and functionalization of MoS2; emphasis on drug delivery, photothermal therapy, and tissue engineering applications

Author

Pourmadadi, Mehrab, Tajiki, Alireza, Hosseini, Seyede Mahtab, Samadi, Amirmasoud, Abdouss, Majid, Daneshnia, Shirin, and Yazdian, Fatemeh

Subjects
Biotechnology, Cancer, Bioengineering, Nanotechnology, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Pharmacology and Pharmaceutical Sciences, Pharmacology & Pharmacy
Abstract

This review article is focused on the drug delivery platforms and cancer treatment systems recently developed based on molybdenum disulfide (MoS2) nanosheets. Two-dimensional MoS2 can be used as a therapeutic nanoparticle and tissue engineering scaffold for tumor healing. Structure, different synthesis methods, unique properties, and surface modification approaches of MoS2 as a newly emerging carrier for a wide range of drugs were comprehensively discussed. Numerous examples of drug delivery systems based on these carriers were introduced, and their key characteristics and highlights were compared in tables. Striking features in the two-dimensional nanostructure state like the high degree of anisotropy, mechanical strength, biocompatibility, large surface area, availability of surface modification methods for enhanced functionality, distinctive band gap structure, high absorbance in the near-infrared region, and remarkable magnetic attributes render MoS2 an ideal and attractive candidate to develop multifunctional platforms for combined chemotherapy and photothermal therapy as well as biosensing and bioimaging applications. These properties have piqued the interest of many researchers and led them to study the versatile biomedical applications of these materials, particularly drug delivery and photothermal therapy. Finally, the opportunities, remaining challenges, and future prospects ahead in this area were mapped out.

Published
2022

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