24 results on '"Pourdast, A."'
Search Results
2. The application of direct viral cytopathic hypothesis to design drug trials in the battle against COVID-19
- Author
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Ashraf, Mohammad Ali, Sherafat, Alireza, Pourdast, Alieh, Nazemi, Pershang, and Mohraz, Minoo
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- 2020
- Full Text
- View/download PDF
3. Effect of SeptimebTM as a new natural extract on severe sepsis: A randomized clinical trial
- Author
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Alieh Pourdast, Maryam Sanaie, Sirous Jafari, Mostafa Mohammadi, Hossein Khalili, Gita Shafiee, Zeinab Ahadi, Mahsa Rostami, Saba Alizad, Ramin Heshmat, and Minoo Mohraz
- Subjects
Sepsis ,Septimeb ,Infection ,Inflammatory ,Internal medicine ,RC31-1245 - Abstract
Background: Septimeb as a herbal medicine has regulatory effects on inflammation. This study set to evaluate the effects of Septimeb among patients with sepsis on inflammatory biomarkers and survival rate. Methods: In this randomized clinical trial, 51 patients with sepsis from the ICU and medical ward of Imam Khomeini Hospital were divided into two groups: Septimeb (n=25) and control group (n=26). In the control group, the patients received a standard treatment only for 7 days, while Septimeb group received Septimeb (6cc vial with 500cc serum glucose infusion 5% daily for one to two hours) plus standard treatment of sepsis for 7 days. Then, blood samples were analyzed. APACHE (Acute Physiologic and Chronic Health Evaluation), SOFA (Sequential Organ Failure Assessment), and GCS (Glasgow Coma Score) values were calculated daily. Results: Treatment with Septimeb showed a significant decrease in SOFA value (1.54±0.83) compared to the control group (2.39±0.88) (P
- Published
- 2017
4. COVID-19, An early investigation from exposure to treatment outcomes in Tehran, Iran
- Author
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Talat Mokhtari Azad, Pershang Nazemi, Avin Mabadi, Milad Sanginabadi, Nasim Shokouhi, Omeed Memar, Fateme Davari-Tanha, Elham Shirali, Tahereh Poordast, Alieh Pourdast, Kiana Shirani, Adele Ossareh, Leila Aghaghazvini, Sara Ghaderkhani, Alireza Kamalipour, Ayein Azarnoush, and Mohammad Ali Ashraf
- Subjects
medicine.medical_specialty ,Lung ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Treatment outcome ,severe acute respiratory syndrome-CoV-2 ,Lopinavir ,Hydroxychloroquine ,General Medicine ,Disease ,2019-novel coronavirus ,treatment outcomes ,medicine.disease ,coronavirus disease 2019 ,medicine.anatomical_structure ,Internal medicine ,medicine ,Ritonavir ,Original Article ,Lymphocytopenia ,business ,clinical characteristics ,medicine.drug - Abstract
Background: There is a growing need for information regarding the recent coronavirus disease of 2019 (COVID-19). We present a comprehensive report of COVID-19 patients in Iran. Materials and Methods: One hundred hospitalized patients with COVID-19 were studied. Data on potential source of exposure, demographic, clinical, and paraclinical features, therapy outcome, and postdischarge follow-up were analyzed. Results: The median age of the patients was 58 years, and the majority of the patients (72.7%) were above 50 years of age. Fever was present in 45.2% of the patients on admission. The most common clinical symptoms were shortness of breath (74%) and cough (68%). Most patients had elevated C-reactive protein (92.3%), elevated erythrocyte sedimentation rate (82.9%), and lymphocytopenia (74.2%) on admission. Lower lobes of the lung were most commonly involved, and ground-glass opacity (81.8%) was the most frequent finding in computed tomography scans. The administration of hydroxychloroquine improved the clinical outcome of the patients. Lopinavir/ritonavir was efficacious at younger ages. Of the 70 discharged patients, 40% had symptom aggravation, 8.6% were readmitted to the hospital, and three patients (4.3%) died. Conclusion: This report demonstrates a heterogeneous nature of clinical manifestations in patients affected with COVID19. The most common presenting symptoms are nonspecific, so attention should be made on broader testing, especially in age groups with the greatest risk and younger individuals who can serve as carriers of the disease. Hydroxychloroquine and lopinavir/ritonavir (in younger age group) can be potential treatment options. Finally, patients discharged from the hospital should be followed up because of potential symptom aggravation.
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- 2021
5. Coronavirus Disease 2019 (COVID-19): A Systematic Review of Pregnancy and the Possibility of Vertical Transmission
- Author
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Mohammad Ali, Ashraf, Pedram, Keshavarz, Parisa, Hosseinpour, Amirhossein, Erfani, Amirhossein, Roshanshad, Alieh, Pourdast, Peyman, Nowrouzi-Sohrabi, Shahla, Chaichian, and Tahereh, Poordast
- Subjects
Coronavirus Disease 2019 (COVID-19) ,Neonatal outcomes ,Pregnancy ,SARS-CoV-2 ,Pregnant women ,Vertical transmission ,Systematic Review - Abstract
Background: There is a growing need for information regarding maternal and neonatal outcomes during coronavirus pandemic. In this study, a comprehensive investigation was done regarding the possibility of vertical transmission using the available data in the literature. Methods: A systematic search was conducted using electronic databases, including PubMed, Scopus, Web of Science, Embase, and Scholar. All studies containing infected COVID-19 pregnant women who had given birth were included, and the search was done up to April 14, 2020. Results: Overall, 21 articles were reviewed, and clinical characteristics of 90 pregnant patients and 92 neonates born to mothers infected with COVID-19 were reviewed. The most common symptoms included fever, cough, and dyspnea. The main laboratory findings included leukocytosis, lymphopenia, thrombocytopenia, and elevated C-reactive protein. The most commonly reported complications were preterm labor and fetal distress. Three mothers were admitted to ICU and required mechanical ventilation; among them, one died, and one was on extracorporeal membrane oxygenation. Overall, 86 neonates were tested for the possibility of vertical transmission and 82 cases were negative in RT-PCR, while 4 were positive. Out of 92 neonates, one died, and one was born dead. Nineteen patients reported having no symptoms, while breathing problems and pneumonia were reported as the most common neonatal complications. Conclusion: There were no differences in the clinical characteristics of pregnant women and non-pregnant COVID-19 patients. COVID-19 infection has caused higher incidence of fetal distress and premature labor in pregnant women. Although the possibility of vertical transmission in infected pregnant women is rare, four neonates’ test results for COVID-19 infection were positive in this review.
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- 2020
6. COVID-19 in Iran, a comprehensive investigation from exposure to treatment outcomes
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Omeed Memar, Elham Shirali, Ayein Azarnoush, Talat Mokhtari Azad, Milad Sanginabadi, Leila Aghaghazvini, Avin Mabadi, Tahereh Poordast, Adele Ossareh, Mohammad Ali Ashraf, Nasim Shokouhi, Alieh Pourdast, Fateme Davari-Tanha, Sara Ghaderkhani, Pershang Nazemi, and Alireza Kamalipour
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medicine.medical_specialty ,Lung ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Treatment outcome ,Hydroxychloroquine ,Lopinavir ,Disease ,medicine.disease ,medicine.anatomical_structure ,Internal medicine ,medicine ,Ritonavir ,Lymphocytopenia ,business ,medicine.drug - Abstract
Background There is a growing need for information regarding the recent coronavirus disease of 2019 (Covid-19). We present a comprehensive report of Covid-19 patients in Iran.Methods One hundred hospitalized patients with Covid-19 were studied. Data on potential source of exposure, demographic, clinical, and paraclinical features, therapy outcome, and post-discharge follow-up were analyzed.Results The median age of the patients was 58 years, and the majority of the patients (72.7%) were above 50 years of age. Fever was present in 45.2% of the patients on admission. The most common clinical symptoms were shortness of breath (74%) and cough (68%). Most patients had elevated C-reactive protein (92.3%), elevated erythrocyte sedimentation rate (82.9%), lymphocytopenia (74.2 %) on admission. Lower lobes of the lung were most commonly involved, and ground-glass opacity (81.8%) was the most frequent finding in CT scans. The administration of hydroxychloroquine improved the clinical outcome of the patients. Lopinavir/ritonavir was efficacious at younger ages. Of the 70 discharged patients, 40% had symptom relapse, (8.6%) were readmitted to the hospital, and 3 patients (4.3%) died.Conclusions This report demonstrates a heterogeneous nature of clinical manifestations in patients affected with Covid-19. The most common presenting symptoms are non-specific, so attention should be made on broader testing, especially in age groups with the greatest risk and younger individuals who can serve as carriers of the disease. Hydroxychloroquine and lopinavir/ritonavir (in younger age group) can be potential treatment options. Finally, patients discharged from the hospital should be followed up because of potential symptom relapse.
- Published
- 2020
7. COVID-19 in Iran, a comprehensive investigation from exposure to treatment outcomes
- Author
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Mohammad Ali Ashraf, Nasim Shokouhi, Elham Shirali, Fateme Davari-tanha, Omeed Memar, Alireza Kamalipour, Ayein Azarnoush, Avin Mabadi, Adele Ossareh, Milad Sanginabadi, Talat Mokhtari Azad, Leila Aghaghazvini, Sara Ghaderkhani, Tahereh Poordast, Alieh Pourdast, and Pershang Nazemi
- Abstract
PurposeThere is a growing need for information regarding the recent coronavirus disease of 2019 (Covid-19). We present a comprehensive report of Covid-19 patients in Iran.MethodsOne hundred hospitalized patients with Covid-19 were studied. Data on potential source of exposure, demographic, clinical, and paraclinical features, therapy outcome, and post-discharge follow-up were analyzed.ResultsThe median age of the patients was 58 years, and the majority of the patients (72.7%) were above 50 years of age. Fever was present in 45.2% of the patients on admission. The most common clinical symptoms were shortness of breath (74%) and cough (68%). Most patients had elevated C-reactive protein (92.3%), elevated erythrocyte sedimentation rate (82.9%), lymphocytopenia (74.2 %) on admission. Lower lobes of the lung were most commonly involved, and ground-glass opacity (81.8%) was the most frequent finding in CT scans. The administration of hydroxychloroquine improved the clinical outcome of the patients. Lopinavir/ritonavir was efficacious at younger ages. Of the 70 discharged patients, 40% had symptom relapse, (8.6%) were readmitted to the hospital, and 3 patients (4.3%) died.ConclusionThis report demonstrates a heterogeneous nature of clinical manifestations in patients affected with Covid-19. The most common presenting symptoms are non-specific, so attention should be made on broader testing, especially in age groups with the greatest risk and younger individuals who can serve as carriers of the disease. Hydroxychloroquine and lopinavir/ritonavir (in younger age group) can be potential treatment options. Finally, patients discharged from the hospital should be followed up because of potential symptom relapse.
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- 2020
- Full Text
- View/download PDF
8. The Effect of First- and Second-Line Antiretroviral Therapies on Lipid Profile of HIV/AIDS Patients
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Rasoolinejad, Mehrnaz, primary, Asadollahi–Amin, Ali, additional, Dadras, Omid, additional, Pourdast, Alieh, additional, Ghavam, Syyedmohamad, additional, SeyedAlinaghi, SeyedAhmad, additional, Jafari, Masoud, additional, Hasannejad, Malihe, additional, and Moradmand-Badie, Banafsheh, additional
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- 2021
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9. COVID-19, An early investigation from exposure to treatment outcomes in Tehran, Iran
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Nazemi, Pershang, primary, Ashraf, MohammadAli, additional, Shokouhi, Nasim, additional, Shirali, Elham, additional, Davari-Tanha, Fateme, additional, Shirani, Kiana, additional, Memar, Omeed, additional, Kamalipour, Alireza, additional, Azarnoush, Ayein, additional, Mabadi, Avin, additional, Ossareh, Adele, additional, Sanginabadi, Milad, additional, Azad, TalatMokhtari, additional, Aghaghazvini, Leila, additional, Ghaderkhani, Sara, additional, Poordast, Tahereh, additional, and Pourdast, Alieh, additional
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- 2021
- Full Text
- View/download PDF
10. COVID-19 in Iran, a comprehensive investigation from exposure to treatment outcomes
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Ashraf, Mohammad Ali, primary, Shokouhi, Nasim, additional, Shirali, Elham, additional, Davari-tanha, Fateme, additional, Memar, Omeed, additional, Kamalipour, Alireza, additional, Azarnoush, Ayein, additional, Mabadi, Avin, additional, Ossareh, Adele, additional, Sanginabadi, Milad, additional, Azad, Talat Mokhtari, additional, Aghaghazvini, Leila, additional, Ghaderkhani, Sara, additional, Poordast, Tahereh, additional, Pourdast, Alieh, additional, and Nazemi, Pershang, additional
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- 2020
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- View/download PDF
11. The application of direct viral cytopathic hypothesis to design drug trials in the battle against COVID-19
- Author
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Mohammad Ali Ashraf, Pershang Nazemi, Alireza Sherafat, Minoo Mohraz, and Alieh Pourdast
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ARDS ,Drug trial ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Disease ,Antiviral Agents ,01 natural sciences ,Pathogenesis ,Coronavirus disease of 2019 (COVID-19) ,In vivo ,medicine ,Coagulopathy ,Direct viral cytopathy ,Humans ,Letter to the Editor ,Clinical Trials as Topic ,SARS-CoV-2 ,business.industry ,COVID-19 ,Building and Construction ,medicine.disease ,COVID-19 Drug Treatment ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Potential therapies ,Research Design ,Immunology ,business - Abstract
COVID-19 has caused many deaths worldwide. Systemic complications alongside coagulopathy, and ARDS account for the majority of COVID-19 mortalities. The pathogenesis of the disease can be explained by two theories of direct viral cytopathy and systemic inflammatory cascade of events. ACE-2 is shown to be the cellular host receptor for SARS-CoV-2. It might be the key to explain the pathogenesis of systemic complications with a focus on the direct viral cytopathic hypothesis. Different medications tend to show up in many in vitro drug screens. However, more trials are needed to translate their application into in vivo efficacy.
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- 2020
12. COVID-19, An early investigation from exposure to treatment outcomes in Tehran, Iran.
- Author
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Ashraf, Mohammad Ali, Shokouhi, Nasim, Shirali, Elham, Davari-Tanha, Fateme, Shirani, Kiana, Memar, Omeed, Kamalipour, Alireza, Azarnoush, Ayein, Mabadi, Avin, Ossareh, Adele, Sanginabadi, Milad, Azad, Talat Mokhtari, Aghaghazvini, Leila, Ghaderkhani, Sara, Poordast, Tahereh, Pourdast, Alieh, and Nazemi, Pershang
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C-reactive protein ,COVID-19 ,TREATMENT effectiveness ,DYSPNEA ,LYMPHOPENIA ,HOSPITAL care ,DESCRIPTIVE statistics ,COUGH ,BLOOD sedimentation ,INFORMATION needs ,COMPUTED tomography ,HYDROXYCHLOROQUINE ,LOPINAVIR-ritonavir - Abstract
Background: There is a growing need for information regarding the recent coronavirus disease of 2019 (COVID-19). We present a comprehensive report of COVID-19 patients in Iran. Materials and Methods: One hundred hospitalized patients with COVID-19 were studied. Data on potential source of exposure, demographic, clinical, and paraclinical features, therapy outcome, and postdischarge follow-up were analyzed. Results: The median age of the patients was 58 years, and the majority of the patients (72.7%) were above 50 years of age. Fever was present in 45.2% of the patients on admission. The most common clinical symptoms were shortness of breath (74%) and cough (68%). Most patients had elevated C-reactive protein (92.3%), elevated erythrocyte sedimentation rate (82.9%), and lymphocytopenia (74.2%) on admission. Lower lobes of the lung were most commonly involved, and ground-glass opacity (81.8%) was the most frequent finding in computed tomography scans. The administration of hydroxychloroquine improved the clinical outcome of the patients. Lopinavir/ritonavir was efficacious at younger ages. Of the 70 discharged patients, 40% had symptom aggravation, 8.6% were readmitted to the hospital, and three patients (4.3%) died. Conclusion: This report demonstrates a heterogeneous nature of clinical manifestations in patients affected with COVID19. The most common presenting symptoms are nonspecific, so attention should be made on broader testing, especially in age groups with the greatest risk and younger individuals who can serve as carriers of the disease. Hydroxychloroquine and lopinavir/ritonavir (in younger age group) can be potential treatment options. Finally, patients discharged from the hospital should be followed up because of potential symptom aggravation. [ABSTRACT FROM AUTHOR]
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- 2021
- Full Text
- View/download PDF
13. The Impact of Communication and Information Technology on the Evolution of the concept of Power
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Ahmad Soltani nejad, Muhammad Hosein Jamshidi, and Zahra Pourdast
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power ,soft power ,information technology ,socialization of power ,hard power ,lcsh:Political science ,lcsh:J - Abstract
Power as one of the main concepts of international relation science has a history as old as civilized humanity. This significant concept has evolved in the aftermath of the Cold War under the impact of different factors, especially modern information technologies and social networks. One substantial development is the transformation of hard power to soft power. The worldwide changes in information has led to the transformation of the concept and arena of power. Therefore, the idea of soft power has been more important as a means and aim in the international arena. Moreover, the cultural and soft aspect of power has become the main issue of international relations. The main goal of this paper is to see how new information technology changed the concept and function of power. The findings show that there are reliable relations between the formation of new information technology and the evolution of the concept of power. With normalization and socialization of the concept of power, the geographical boundaries and the source of power have been affected.
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- 2016
14. Prevalence of Adverse Drug Reactions to Highly Active Antiretroviral Therapy (HAART) among HIV Positive Patients in Imam Khomeini Hospital of Tehran, Iran
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Mehrnaz Rasoolinejad, Saeed Reza Jamali Moghadam, Hamid Emadi Koochak, Sepideh Khodaei, Seyed Ahmad Seyed Alinaghi, Raheleh Golrokhy, Azita Babaii, Alia Pourdast, and Reza R Taheri
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Adult ,Male ,0301 basic medicine ,Microbiology (medical) ,Drug ,medicine.medical_specialty ,Tuberculosis ,Adolescent ,Anti-HIV Agents ,Opportunistic infection ,Cross-sectional study ,media_common.quotation_subject ,Voluntary counseling and testing ,HIV Infections ,Iran ,Young Adult ,03 medical and health sciences ,Antiretroviral Therapy, Highly Active ,Internal medicine ,Prevalence ,medicine ,Humans ,Child ,Aged ,media_common ,Pharmacology ,AIDS-Related Opportunistic Infections ,Coinfection ,business.industry ,General Medicine ,Hepatitis C ,Middle Aged ,medicine.disease ,030112 virology ,Rash ,CD4 Lymphocyte Count ,Surgery ,Treatment Adherence and Compliance ,Cross-Sectional Studies ,Child, Preschool ,Molecular Medicine ,Female ,medicine.symptom ,business ,Adverse drug reaction - Abstract
Objective: The present study assessed the prevalence of adverse drug reactions (ADRs) among HIV positive patients referred to Imam Khomeini hospital in Tehran, Iran. Methods: This is a cross sectional study regarding side effects of Highly Active Antiretroviral Therapy (HAART) in HIV positive patients referred to Voluntary Counseling and Testing (VCT) center in Imam Khomeini Hospital of Tehran, Iran during a period of the year 2009 to 2010. Two hundred patients under antiretroviral treatment evaluated for the side effects of drug based on available records, face to face interviews and written lab data. Results: Data was collected from a sample of 200 HIV positive patients (72% male). Injection drug use was the most common route of HIV transmission. Co-infections were found in the majority of patients (60.5%). Eleven percent had positive test for Hepatitis C (HCV). Tuberculosis was the most prevalent opportunistic infection. 188 (94%) patients experienced at least one adverse drug reaction. The most frequent clinical and para clinical findings were skin rash (28%) and abnormal liver function tests (36%). Conclusions: Given the high prevalence of adverse drug reactions among HIV positive patients taking antiretroviral therapy (ART) in this study, clinicians should be aware of ADRs at the initiation of ART as complications can affect patients’ adherence to the therapy.
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- 2017
15. Effect of Septimeb
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Alieh, Pourdast, Maryam, Sanaei, Sirous, Jafari, Mostafa, Mohammadi, Hossein, Khalili, Gita, Shafiee, Zeinab, Ahadi, Mahsa, Rostami, Saba, Alizad, Ramin, Heshmat, and Minoo, Mohraz
- Subjects
Sepsis ,Original Article ,Anti-inflammatory effects ,Septimeb ,Infection - Abstract
Background: Septimeb as a herbal medicine has regulatory effects on inflammation. This study set to evaluate the effects of Septimeb among patients with sepsis on inflammatory biomarkers and survival rate. Methods: In this randomized clinical trial, 51 patients with sepsis from the ICU and medical ward of Imam Khomeini Hospital were divided into two groups: Septimeb (n=25) and control group (n=26). In the control group, the patients received a standard treatment only for 7 days, while Septimeb group received Septimeb (6cc vial with 500cc serum glucose infusion 5% daily for one to two hours) plus standard treatment of sepsis for 7 days. Then, blood samples were analyzed. APACHE (Acute Physiologic and Chronic Health Evaluation), SOFA (Sequential Organ Failure Assessment), and GCS (Glasgow Coma Score) values were calculated daily. Results: Treatment with Septimeb showed a significant decrease in SOFA value (1.54±0.83) compared to the control group (2.39±0.88) (P
- Published
- 2017
16. Impacts of the G145R Mutation on the Structure and Immunogenic Activity of the Hepatitis B Surface Antigen: A Computational Analysis
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Alieh Pourdast, Vahdat Poortahmasebi, Saeideh Najafi, Reza Rezaee, Mansour Poorebrahim, Seyed Ehsan Alavian, Solmaz Sadeghi, and Seyed Moayed Alavian
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0301 basic medicine ,HBsAg ,medicine.drug_class ,Mutant ,medicine.disease_cause ,Monoclonal antibody ,03 medical and health sciences ,0302 clinical medicine ,Vaccine Escape Mutations ,Antigen ,Medicine ,Hepatitis B virus ,Hepatology ,biology ,business.industry ,virus diseases ,HBsAg Mutations ,Hepatitis B ,medicine.disease ,Virology ,digestive system diseases ,030104 developmental biology ,Infectious Diseases ,Docking (molecular) ,G145R Mutation ,biology.protein ,030211 gastroenterology & hepatology ,Antibody ,business ,Research Article - Abstract
Background Vaccine-escaped hepatitis B virus (HBV) mutations occur within the "a" determinant area, which is located in the major hydrophilic region (MHR) of the hepatitis B surface antigen (HBsAg) protein. It is now well established that the common G145R mutation is highly capable of escaping from HBsAg immune recognition. However, the impacts of this mutation on the structure and immunogenic activity of HBsAg have been poorly investigated. Objectives The present study analyzed the effects of the G145R mutation on the structure and immunogenic activity of the HBsAg. Materials and methods Three-dimensional (3D) structure of HBsAg for both the wild-type and G145R mutant were predicted and refined using several web tools. After quantitative evaluations, the effects of the G145R mutation on the secondary and 3D structures of the HBsAg were investigated. In parallel, the immunogenic activity of the wild-type and mutant HBsAg was also analyzed using a ClusPro docking server as well as the IEDB web tool. Further analyses were performed via molecular dynamics (MD) simulations using the GROMACS v5.0.2 simulation package. Results The G145R mutation causes a considerable reduction in the immunogenic activity of the HBsAg through a conformational change in the HBsAg antigenic loops. This mutation inserts a new β-strand in the "a" determinant region of the HBsAg, leading to a reduced binding affinity to its monoclonal antibody, MAb12. The G145R mutation also increased the compactness and stability of the HBsAg by enhancing the rigidity of the "a" determinant. Conclusions These data will be beneficial for designing more advanced antibodies for the recognition of the HBsAg in diagnostics. In addition, the results of this study may assist in the design or development of more effective hepatitis B vaccines.
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- 2016
17. Prevalence of Adverse Drug Reactions to Highly Active Antiretroviral Therapy (HAART) among HIV Positive Patients in Imam Khomeini Hospital of Tehran, Iran
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Koochak, Hamid E., primary, Babaii, Azita, additional, Pourdast, Alia, additional, Golrokhy, Raheleh, additional, Rasoolinejad, Mehrnaz, additional, Khodaei, Sepideh, additional, Moghadam, Saeed R. J., additional, Taheri, Reza R., additional, and Seyed Alinaghi, Seyed Ahmad, additional
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- 2017
- Full Text
- View/download PDF
18. Impacts of the G145R Mutation on the Structure and Immunogenic Activity of the Hepatitis B Surface Antigen: A Computational Analysis
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Rezaee, Reza, primary, Poorebrahim, Mansour, additional, Najafi, Saeideh, additional, Sadeghi, Solmaz, additional, Pourdast, Alieh, additional, Alavian, Seyed Moayed, additional, Alavian, Seyed Ehsan, additional, and Poortahmasebi, Vahdat, additional
- Published
- 2016
- Full Text
- View/download PDF
19. Effect of Septimeb™ as a new natural extract on severe sepsis: A randomized clinical trial
- Author
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Pourdast, A., Sanaei, M., Jafari, S., Mohammadi, M., Khalili, H., Shafiee, G., Zeinab Ahadi, Rostami, M., Alizad, S., Heshmat, R., and Mohraz, M.
20. The effect of treatment of bacterial vaginosis on pregnancy outcome
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zohreh tavana, Zolghadri, J., Hadaiegh, M. J., and Pourdast, T.
21. Th17-related cytokine profile in preeclampsia patients: the role of pro-inflammatory cytokines as mediators of abortion or predictors of disease?
- Author
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Baharlou, R., Ahmadi, A., Pourdast, T., and Khoubyari, M.
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ENZYME-linked immunosorbent assay ,INTERLEUKINS ,PREECLAMPSIA ,CONTROL groups ,PREGNANCY - Abstract
Introduction: Preeclampsia (PE) is a medical condition characterized by high blood pressure and significant amounts of protein in a pregnant woman‘s urine. If left untreated, it can develop into eclampsia and life-threatening occurrence of seizures during pregnancy that may lead to fetal and maternal deaths. Although the etiology of preeclampsia remains unknown, there are many proposed theories regarding the pathogenesis of the preeclamptic disease processes: oxidative stress, abnormal trophoblast invasion, vascular endothelial dysfunction, genetic predisposition, dietary deficiencies, and defective immunological adaptation to pregnancy. Several lines of evidence also support the concept that preeclampsia is an excessive maternal inflammatory response to normal pregnancy. We, therefore, examined IL-17 expression in the peripheral blood of patients with PE. Materials and Methods: The peripheral blood was collected from patients with PE (30 patients), normal pregnant control group (30 volunteers) and non-pregnant normal control group (30 healthy people) as control groups in hospitals affiliated to Jahrom University of Medical Sciences. Serums were then, isolated and assessed for IL-17 using by ELISA (ebiosciences kit). Results: The cytokine profile in preeclampsia shows that the production of Th17 cytokines, which induce inflammation. Maternal cytokine levels IL-17 and TGF-β are increased during preeclampsia as compared to normal pregnancy and non-pregnancy. Conclusion: Cytokines have major roles in the pathogenesis of preeclampsia. It seems that circulating placental microvesicles which are shed by placenta influence on immune cells increase inflammatory cytokines such as IL-1, IL-2, IL-6, IL-8, IL-12, IL-17, TGF-β, G-CSF, IFN-γ, MCP-1, MIP-1, RANTES and TNF-α. Consistent with elevated innate cytokine levels including TGF-β and IL-6 in the maternal circulation, placental tissue and blood cytokine levels from Th17 are also altered, that implies that Th17 inflammatory responses which may occur both in maternal and placental compartments. Therefore, increased inflammatory factors may lead to abortion. On the other hand, we can use inflammatory biomarkers as noninvasive predictors at the outset of diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2014
22. Coronavirus Disease 2019 (COVID-19): A Systematic Review of Pregnancy and the Possibility of Vertical Transmission.
- Author
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Ashraf, Mohammad Ali, Keshavarz, Pedram, Hosseinpour, Parisa, Erfani, Amirhossein, Roshanshad, Amirhossein, Pourdast, Alieh, Nowrouzi-Sohrabi, Peyman, Chaichian, Shahla, and Poordast, Tahereh
- Subjects
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FETAL distress , *MEDICAL information storage & retrieval systems , *PREMATURE labor , *EVALUATION of medical care , *MEDLINE , *ONLINE information services , *PREGNANT women , *SYSTEMATIC reviews , *VERTICAL transmission (Communicable diseases) , *COVID-19 , *PREGNANCY - Abstract
Background: There is a growing need for information regarding maternal and neonatal outcomes during coronavirus pandemic. In this study, a comprehensive investigation was done regarding the possibility of vertical transmission using the available data in the literature. Methods: A systematic search was conducted using electronic databases, including PubMed, Scopus, Web of Science, Embase, and Scholar. All studies containing infected COVID-19 pregnant women who had given birth were included, and the search was done up to April 14, 2020. Results: Overall, 21 articles were reviewed, and clinical characteristics of 90 pregnant patients and 92 neonates born to mothers infected with COVID-19 were reviewed. The most common symptoms included fever, cough, and dyspnea. The main laboratory findings included leukocytosis, lymphopenia, thrombocytopenia, and elevated C-reactive protein. The most commonly reported complications were preterm labor and fetal distress. Three mothers were admitted to ICU and required mechanical ventilation; among them, one died, and one was on extracorporeal membrane oxygenation. Overall, 86 neonates were tested for the possibility of vertical transmission and 82 cases were negative in RT-PCR, while 4 were positive. Out of 92 neonates, one died, and one was born dead. Nineteen patients reported having no symptoms, while breathing problems and pneumonia were reported as the most common neonatal complications. Conclusion: There were no differences in the clinical characteristics of pregnant women and non-pregnant COVID-19 patients. COVID-19 infection has caused higher incidence of fetal distress and premature labor in pregnant women. Although the possibility of vertical transmission in infected pregnant women is rare, four neonates' test results for COVID-19 infection were positive in this review. [ABSTRACT FROM AUTHOR]
- Published
- 2020
23. Effect of Septimeb TM as a new natural extract on severe sepsis: A randomized clinical trial.
- Author
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Pourdast A, Sanaei M, Jafari S, Mohammadi M, Khalili H, Shafiee G, Ahadi Z, Rostami M, Alizad S, Heshmat R, and Mohraz M
- Abstract
Background: Septimeb as a herbal medicine has regulatory effects on inflammation. This study set to evaluate the effects of Septimeb among patients with sepsis on inflammatory biomarkers and survival rate., Methods: In this randomized clinical trial, 51 patients with sepsis from the ICU and medical ward of Imam Khomeini Hospital were divided into two groups: Septimeb (n=25) and control group (n=26). In the control group, the patients received a standard treatment only for 7 days, while Septimeb group received Septimeb (6cc vial with 500cc serum glucose infusion 5% daily for one to two hours) plus standard treatment of sepsis for 7 days. Then, blood samples were analyzed. APACHE (Acute Physiologic and Chronic Health Evaluation), SOFA (Sequential Organ Failure Assessment), and GCS (Glasgow Coma Score) values were calculated daily., Results: Treatment with Septimeb showed a significant decrease in SOFA value (1.54±0.83) compared to the control group (2.39±0.88) (P<0.001) and a significant increase in GCS value (14.46±0.88) compared to the control group (12.86±1.78) (P<0.001). Improvements of these values can confirm the potential of Septimeb in the reduction of severity of sepsis (P<0.05). There were significant decreases in lactate and blood sugar and WBC levels. In addition, inflammatory factors such as ESR (Septimeb group: 52.07±34.80, control group: 51.75±42.10, P=0.98) and CRP (Septimeb group: 48.86±23.21, control group: 49.93±36.22, P=0.92) decreased, but did not show a significant reduction., Conclusion: Septimeb has positive effects on reduction of the severity of sepsis which leads to reduction of patients' mortality rates., Competing Interests: The authors declared no conflict of interest.
- Published
- 2017
24. Prevalence of Adverse Drug Reactions to Highly Active Antiretroviral Therapy (HAART) among HIV Positive Patients in Imam Khomeini Hospital of Tehran, Iran.
- Author
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Koochak HE, Babaii A, Pourdast A, Golrokhy R, Rasoolinejad M, Khodaei S, Moghadam SRJ, Taheri RR, and Seyed Alinaghi SA
- Subjects
- AIDS-Related Opportunistic Infections drug therapy, Adolescent, Adult, Aged, Anti-HIV Agents therapeutic use, CD4 Lymphocyte Count, Child, Child, Preschool, Coinfection drug therapy, Coinfection epidemiology, Coinfection microbiology, Coinfection virology, Cross-Sectional Studies, Female, HIV Infections complications, HIV Infections transmission, HIV Infections virology, Hepatitis C complications, Humans, Iran epidemiology, Male, Middle Aged, Prevalence, Treatment Adherence and Compliance, Tuberculosis complications, Young Adult, Anti-HIV Agents adverse effects, Antiretroviral Therapy, Highly Active adverse effects, HIV Infections drug therapy
- Abstract
Objective: The present study assessed the prevalence of adverse drug reactions (ADRs) among HIV positive patients taking antiretroviral therapy referred to Imam Khomeini Hospital in Tehran, Iran., Methods: This is a cross sectional study regarding side effects of Highly Active Antiretroviral Therapy (HAART) in HIV positive patients referred to Voluntary Counseling and Testing (VCT) center in Imam Khomeini Hospital of Tehran, Iran during a period of the year 2009 to 2010. Two hundred patients under antiretroviral treatment evaluated for the side effects of drug based on available records, face to face interviews and written lab data., Results: Data was collected from a sample of 200 HIV positive patients (72% male). Injection drug use was the most common route of HIV transmission. Co-Infections with Hepatitis C virus (HCV) found in the majority of patients (60.5%). Tuberculosis was the most prevalent opportunistic infection. One hundred eighty eight (94%) patients experienced at least one adverse drug reaction. The most frequent clinical and paraclinical findings were skin rash (28%) and abnormal liver function tests (36%)., Conclusion: Given the high prevalence of adverse drug reactions among HIV positive patients taking antiretroviral therapy (ART) in this study, clinicians should be aware of ADRs at the initiation of ART as complications can affect patients' adherence to the therapy., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
- Published
- 2017
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