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16 results on '"Poulin, Emily J."'

1. Discovery of a selective inhibitor of doublecortin like kinase 1

Author

Ferguson, Fleur M., Nabet, Behnam, Raghavan, Srivatsan, Liu, Yan, Leggett, Alan L., Kuljanin, Miljan, Kalekar, Radha L., Yang, Annan, He, Shuning, Wang, Jinhua, Ng, Raymond W. S., Sulahian, Rita, Li, Lianbo, Poulin, Emily J., Huang, Ling, Koren, Jost, Dieguez-Martinez, Nora, Espinosa, Sergio, Zeng, Zhiyang, Corona, Cesear R., Vasta, James D., Ohi, Ryoma, Sim, Taebo, Kim, Nam Doo, Harshbarger, Wayne, Lizcano, Jose M., Robers, Matthew B., Muthaswamy, Senthil, Lin, Charles Y., Look, A. Thomas, Haigis, Kevin M., Mancias, Joseph D., Wolpin, Brian M., Aguirre, Andrew J., Hahn, William C., Westover, Kenneth D., and Gray, Nathanael S.

Published
2020
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3. Supplementary Table S12 from Tissue-Specific Oncogenic Activity of KRASA146T

Author

Poulin, Emily J., primary, Bera, Asim K., primary, Lu, Jia, primary, Lin, Yi-Jang, primary, Strasser, Samantha Dale, primary, Paulo, Joao A., primary, Huang, Tannie Q., primary, Morales, Carolina, primary, Yan, Wei, primary, Cook, Joshua, primary, Nowak, Jonathan A., primary, Brubaker, Douglas K., primary, Joughin, Brian A., primary, Johnson, Christian W., primary, DeStefanis, Rebecca A., primary, Ghazi, Phaedra C., primary, Gondi, Sudershan, primary, Wales, Thomas E., primary, Iacob, Roxana E., primary, Bogdanova, Lana, primary, Gierut, Jessica J., primary, Li, Yina, primary, Engen, John R., primary, Perez-Mancera, Pedro A., primary, Braun, Benjamin S., primary, Gygi, Steven P., primary, Lauffenburger, Douglas A., primary, Westover, Kenneth D., primary, and Haigis, Kevin M., primary

Published
2023
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4. Supplementary Tables S14-S17 from Tissue-Specific Oncogenic Activity of KRASA146T

Author

Poulin, Emily J., primary, Bera, Asim K., primary, Lu, Jia, primary, Lin, Yi-Jang, primary, Strasser, Samantha Dale, primary, Paulo, Joao A., primary, Huang, Tannie Q., primary, Morales, Carolina, primary, Yan, Wei, primary, Cook, Joshua, primary, Nowak, Jonathan A., primary, Brubaker, Douglas K., primary, Joughin, Brian A., primary, Johnson, Christian W., primary, DeStefanis, Rebecca A., primary, Ghazi, Phaedra C., primary, Gondi, Sudershan, primary, Wales, Thomas E., primary, Iacob, Roxana E., primary, Bogdanova, Lana, primary, Gierut, Jessica J., primary, Li, Yina, primary, Engen, John R., primary, Perez-Mancera, Pedro A., primary, Braun, Benjamin S., primary, Gygi, Steven P., primary, Lauffenburger, Douglas A., primary, Westover, Kenneth D., primary, and Haigis, Kevin M., primary

Published
2023
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5. Data from Tissue-Specific Oncogenic Activity of KRASA146T

Author

Poulin, Emily J., primary, Bera, Asim K., primary, Lu, Jia, primary, Lin, Yi-Jang, primary, Strasser, Samantha Dale, primary, Paulo, Joao A., primary, Huang, Tannie Q., primary, Morales, Carolina, primary, Yan, Wei, primary, Cook, Joshua, primary, Nowak, Jonathan A., primary, Brubaker, Douglas K., primary, Joughin, Brian A., primary, Johnson, Christian W., primary, DeStefanis, Rebecca A., primary, Ghazi, Phaedra C., primary, Gondi, Sudershan, primary, Wales, Thomas E., primary, Iacob, Roxana E., primary, Bogdanova, Lana, primary, Gierut, Jessica J., primary, Li, Yina, primary, Engen, John R., primary, Perez-Mancera, Pedro A., primary, Braun, Benjamin S., primary, Gygi, Steven P., primary, Lauffenburger, Douglas A., primary, Westover, Kenneth D., primary, and Haigis, Kevin M., primary

Published
2023
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6. Supplementary Figures S1-S18 from Tissue-Specific Oncogenic Activity of KRASA146T

Author

Poulin, Emily J., primary, Bera, Asim K., primary, Lu, Jia, primary, Lin, Yi-Jang, primary, Strasser, Samantha Dale, primary, Paulo, Joao A., primary, Huang, Tannie Q., primary, Morales, Carolina, primary, Yan, Wei, primary, Cook, Joshua, primary, Nowak, Jonathan A., primary, Brubaker, Douglas K., primary, Joughin, Brian A., primary, Johnson, Christian W., primary, DeStefanis, Rebecca A., primary, Ghazi, Phaedra C., primary, Gondi, Sudershan, primary, Wales, Thomas E., primary, Iacob, Roxana E., primary, Bogdanova, Lana, primary, Gierut, Jessica J., primary, Li, Yina, primary, Engen, John R., primary, Perez-Mancera, Pedro A., primary, Braun, Benjamin S., primary, Gygi, Steven P., primary, Lauffenburger, Douglas A., primary, Westover, Kenneth D., primary, and Haigis, Kevin M., primary

Published
2023
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9. Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation

Author

Brubaker, Douglas K., primary, Paulo, Joao A., additional, Sheth, Shikha, additional, Poulin, Emily J., additional, Popow, Olesja, additional, Joughin, Brian A., additional, Strasser, Samantha Dale, additional, Starchenko, Alina, additional, Gygi, Steven P., additional, Lauffenburger, Douglas A., additional, and Haigis, Kevin M., additional

Published
2019
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10. Tissue-Specific Oncogenic Activity of KRASA146T

Author

Poulin, Emily J., primary, Bera, Asim K., additional, Lu, Jia, additional, Lin, Yi-Jang, additional, Strasser, Samantha Dale, additional, Paulo, Joao A., additional, Huang, Tannie Q., additional, Morales, Carolina, additional, Yan, Wei, additional, Cook, Joshua, additional, Nowak, Jonathan A., additional, Brubaker, Douglas K., additional, Joughin, Brian A., additional, Johnson, Christian W., additional, DeStefanis, Rebecca A., additional, Ghazi, Phaedra C., additional, Gondi, Sudershan, additional, Wales, Thomas E., additional, Iacob, Roxana E., additional, Bogdanova, Lana, additional, Gierut, Jessica J., additional, Li, Yina, additional, Engen, John R., additional, Perez-Mancera, Pedro A., additional, Braun, Benjamin S., additional, Gygi, Steven P., additional, Lauffenburger, Douglas A., additional, Westover, Kenneth D., additional, and Haigis, Kevin M., additional

Published
2019
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11. The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile

Author

Lyons, Jesse, primary, Ghazi, Phaedra C., additional, Starchenko, Alina, additional, Tovaglieri, Alessio, additional, Baldwin, Katherine R., additional, Poulin, Emily J., additional, Gierut, Jessica J., additional, Genetti, Casie, additional, Yajnik, Vijay, additional, Breault, David T., additional, Lauffenburger, Douglas A., additional, and Haigis, Kevin M., additional

Published
2018
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15. The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor

Author

Powell, Anne E., primary, Wang, Yang, additional, Li, Yina, additional, Poulin, Emily J., additional, Means, Anna L., additional, Washington, Mary K., additional, Higginbotham, James N., additional, Juchheim, Alwin, additional, Prasad, Nripesh, additional, Levy, Shawn E., additional, Guo, Yan, additional, Shyr, Yu, additional, Aronow, Bruce J., additional, Haigis, Kevin M., additional, Franklin, Jeffrey L., additional, and Coffey, Robert J., additional

Published
2012
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16. Loss of Lrig1Leads to Expansion of Brunner Glands Followed by Duodenal Adenomas with Gastric Metaplasia

Author

Wang, Yang, Shi, Chanjuan, Lu, Yuanyuan, Poulin, Emily J., Franklin, Jeffery L., and Coffey, Robert J.

Abstract

Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a pan-ErbB negative regulator and intestinal stem cell marker down-regulated in many malignancies. We previously reported that 14 of 16 Lrig1-CreERT2/CreERT2(Lrig1−/−) mice developed duodenal adenomas, providing the first in vivoevidence that Lrig1 acts as a tumor suppressor. We extended this study to a larger cohort and found that 49 of 54 Lrig1−/−mice develop duodenal adenomas beginning at 3 months. Most adenomas were histologically low grade and overlaid expanded Brunner glands. There was morphologic and biochemical blurring of the boundary between the epithelium and Brunner glands with glandular coexpression of ErbB2, which is normally restricted to the epithelium, and the Brunner gland marker Mucin6. Some adenomas were high grade with reduced Brunner glands. At age 4 to 5 weeks, before adenoma formation, we observed enhanced proliferation in Brunner glands and, at 2 months, an increase in the size of the Brunner gland compartment. Elevated expression of the epidermal growth factor receptor (Egfr) ligands amphiregulin and β-cellulin, as well as Egfr and phosphorylated Egfr, was detected in adenomas compared with adjacent normal tissue. These adenomas expressed the gastric-specific genes gastrokine1 and mucin5ac, indicating gastric metaplasia. Moreover, we found that a subset of human duodenal tumors exhibited features of LRIG1−/−adenomas, including loss of LRIG1, gastric metaplasia (MUCIN5AC and MUCIN6), and increased amphiregulin and Egfr activity.

Published
2015
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