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1. A Wearable Open-Source electrical impedance tomography device

Author

Andrew Creegan, Joshua Bradfield, Samuel Richardson, Llewellyn Sims Johns, Kelly Burrowes, Haribalan Kumar, Poul M.F. Nielsen, and Merryn H. Tawhai

Subjects
Electrical impedance tomography, EIT, Medical imaging, Open source, Wearable, Science (General), Q1-390
Abstract

Electrical impedance tomography (EIT) is medical imaging technique in which small electrical signals are used to map the electrical impedance distribution within the body. It is safe and non-invasive, which make it attractive for use in continuous monitoring or outpatient applications, but the high cost of commercial devices is an impediment to its adoption. Over the last 10 years, many research groups have developed their own EIT devices, but few designs for open-source EIT hardware are available. In this work, we present a complete open-source EIT system that is designed to be suitable for monitoring the lungs of free breathing subjects. The device is low-cost, wearable, and is designed to comply with the industry accepted safety standard for EIT. The device has been tested in two regimes: Firstly in terms of measurement uncertainty as a voltage measurement system, and secondly against a set of measures that have been proposed specifically for EIT hardware. The voltage measurement uncertainty of the device was measured to be − 0.7 % ± 0.36 mV. The EIT specific performance was measured in a phantom test designed to be as physiologically representative as practicable, and the device performed similarly to other published devices. This work will contribute to increased accessibility of EIT for study and will contribute to consensus on testing methodology for EIT devices.

Published
2024
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2. High-Resolution Spatiotemporal Quantification of Intestinal Motility With Free-Form Deformation

Author

Sachira Kuruppu, Leo K. Cheng, Poul M.F. Nielsen, Thiranja P. Babarenda Gamage, Recep Avci, Timothy R. Angeli, and Niranchan Paskaranandavadivel

Subjects
Jejunum, Swine, Urinary Bladder, Biomedical Engineering, Animals, Rabbits, Gastrointestinal Motility, Algorithms, Muscle Contraction
Abstract

To develop a method to quantify strain fields from in vivo intestinal motility recordings that mitigate accumulation of tracking error.The deforming geometry of the intestine in video sequences was modeled by a biquadratic B-spline mesh. Green-Lagrange strain fields were computed to quantify the surface deformations. A nonlinear optimization scheme was applied to mitigate the accumulation of tracking error associated with image registration.The optimization scheme maintained the RMS strain error under 1% and reduced the rate of strain error by 97% during synthetic tests. The algorithm was applied to map 64 segmental, 12 longitudinal, and 23 propagating circular contractions in the jejunum. Coordinated activity of the two muscle layers could be identified and the strain fields were able to map and quantify the anisotropic contractions of the intestine. Frequency and velocity were also quantified, from which two types of propagating circular contractions were identified: (i) [Formula: see text] strain contractions that originated spontaneously and propagated at [Formula: see text] mm/s in two pigs, and (ii) cyclic propagating contractions of [Formula: see text] strain occurred at [Formula: see text] cpm and propagated at [Formula: see text] mm/s in a rabbit.The algorithm simultaneously mapped the circular, longitudinal activity of the intestine with high spatial resolution and quantified anisotropic contractions and relaxations.The proposed algorithm can now be used to define the interactions of muscle layers during motility patterns. It can be integrated with high-resolution bioelectrical recordings to investigate the regulatory mechanisms of motility.

Published
2022

3. Computational Biomechanics for Medicine : Towards Translation and Better Patient Outcomes

Author

Poul M.F. Nielsen, Martyn P. Nash, Xinshan Li, Karol Miller, Adam Wittek, Poul M.F. Nielsen, Martyn P. Nash, Xinshan Li, Karol Miller, and Adam Wittek

Subjects
Biomedical engineering, Biomechanics, Continuum mechanics, Bioinformatics
Abstract

This book presents contributions from the MICCAI 2021 Computational Biomechanics for Medicine Workshop.'Computational Biomechanics for Medicine - towards translation and better patient outcomes” comprises papers accepted for the MICCAI Computational Biomechanics for Medicine Workshop held virtually in conjunction with Medical Image Computing and Computer Assisted Intervention conference 2021, based in Strasbourg. The content focuses on methods and applications of computational biomechanics to medical image analysis, image-guided surgery, surgical simulation, surgical intervention planning, disease prognosis and diagnostics, analysis of injury mechanisms, implant and prostheses design, as well as artificial organ design and medical robotics. This book details state-of-the-art progress in the above fields to researchers, students, and professionals.

Published
2022

4. Computational Biomechanics for Medicine : Personalisation, Validation and Therapy

Author

Martyn P. Nash, Poul M.F. Nielsen, Adam Wittek, Karol Miller, Grand R. Joldes, Martyn P. Nash, Poul M.F. Nielsen, Adam Wittek, Karol Miller, and Grand R. Joldes

Subjects
Biomedical engineering, Mathematics—Data processing, Radiology, Mechanics, Applied, Medical physics, Control engineering, Robotics, Automation
Abstract

This book contains contributions from computational biomechanics specialists who present and exchange opinions on the opportunities for applying their techniques to computer-integrated medicine, including computer-aided surgery and diagnostic systems. Computational Biomechanics for Medicine collects peer-reviewed chapters from the annual Computational Biomechanics for Medicine Workshop, in conjunction with the Medical Image Computing and Computer Assisted Intervention [MICCAI] Society conference. The works are dedicated to research in the field of methods and applications of computational biomechanics to medical image analysis, image-guided surgery, surgical simulation, surgical intervention planning, disease diagnosis and prognosis, analysis of injury mechanisms, implant and prosthesis design, artificial organ design, and medical robotics. These chapters will appeal to a wide range of researchers and students within the fields of engineering and medicine, as well as those working in computational science.

Published
2019

5. Computational Biomechanics for Medicine : From Algorithms to Models and Applications

Author

Adam Wittek, Grand Joldes, Poul M.F. Nielsen, Barry J. Doyle, Karol Miller, Adam Wittek, Grand Joldes, Poul M.F. Nielsen, Barry J. Doyle, and Karol Miller

Subjects
Imaging systems in medicine, Computer-assisted surgery, Biomechanics, Heart--Mechanical properties, Cardiovascular system--Mechanical properties
Abstract

This volume comprises the latest developments in both fundamental science and patient-specific applications, discussing topics such as: cellular mechanics; injury biomechanics; biomechanics of heart and vascular system; medical image analysis; and both patient-specific fluid dynamics and solid mechanics simulations. With contributions from researchers world-wide, the Computational Biomechanics for Medicine series of titles provides an opportunity for specialists in computational biomechanics to present their latest methodologies and advancements.

Published
2017

6. Contributors

Author

Clayton Adam, Davide Ambrosi, Peter Anderson, Stéphane Avril, Thiranja P. Babarenda Gamage, Pierre Badel, Chiara Bellini, Silvia S. Blemker, Mohamed Bader Boubaker, Peter H.M. Bovendeerd, Marek Bucki, Begonã Calvo, Francis Cannard, Matthieu Chabanas, Grégory Chagnon, Simon Chatelin, Hadrien Courtecuisse, Nicolas Curt, Christian J. Cyron, Tammo Delhaas, Hervé Delingette, Elena S. Di Martino, Raphaël Dumas, Olivier Dupuis, Denis Favier, Sidney Fels, Behrooz Fereidoonnezhad, Gérard Finet, Cormac Flynn, Fanny Frauziols, Jean-François Ganghoffer, Alberto Garcia, Thomas C. Gasser, Ahmed M. Gharib, Paul Glass, Hans Gregersen, Negar M. Harandi, Nicolas Hermant, Belén Hernández-Gascón, Andrew Ho, Gerhard A. Holzapfel, Jay D. Humphrey, Yoann Lafon, Sébastien Laporte, Donghua Liao, Vincent Luboz, Mauro Malvè, Stéphanie Marchesseau, Jean-Louis Martiel, Scott Moisik, Jérôme Molimard, Fanny Morin, Martyn P. Nash, Laurent Navarro, Mohammad Ali Nazari, Poul M.F. Nielsen, Jacques Ohayon, Cees W.J. Oomens, Yohan Payan, Estefanía Peña, Pascal Perrier, Antoine Perrier, Gerrit W.M. Peters, Roderic I. Pettigrew, Dominique P. Pioletti, Marieke Pluijmert, Lalao Rakotomanana, Pierre-Yves Rohan, Philippe Rouch, C. Antonio Sánchez, Wafa Skalli, Ian Stavness, Julien Stelletta, Keyi Tang, Maxim Van den Abbeele, Marc van Vijven, Arne Vogel, Nicolas Vuillerme, John S. Wilson, Saami K. Yazdani, Florence Zara, and Jingbo Zhao

Published
2017

7. Computational Biomechanics for Medicine : Imaging, Modeling and Computing

Author

Grand R. Joldes, Barry Doyle, Adam Wittek, Poul M.F. Nielsen, Karol Miller, Grand R. Joldes, Barry Doyle, Adam Wittek, Poul M.F. Nielsen, and Karol Miller

Subjects
Biomechanics
Abstract

The Computational Biomechanics for Medicine titles provide an opportunity for specialists in computational biomechanics to present their latest methodologies and advancements. This volume comprises eighteen of the newest approaches and applications of computational biomechanics, from researchers in Australia, New Zealand, USA, UK, Switzerland, Scotland, France and Russia. Some of the interesting topics discussed are: tailored computational models; traumatic brain injury; soft-tissue mechanics; medical image analysis; and clinically-relevant simulations.One of the greatest challenges facing the computational engineering community is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, the biomedical sciences, and medicine. We hope the research presented within this book series will contribute to overcoming this grand challenge.

Published
2016

8. Computational Biomechanics for Medicine : New Approaches and New Applications

Author

Barry Doyle, Karol Miller, Adam Wittek, Poul M.F. Nielsen, Barry Doyle, Karol Miller, Adam Wittek, and Poul M.F. Nielsen

Subjects
Bioinformatics, Medicine--Data processing, Medical informatics, Biomechanics, Computational biology
Abstract

The Computational Biomechanics for Medicine titles provide an opportunity for specialists in computational biomechanics to present their latest methodologiesand advancements. Thisvolumecomprises twelve of the newest approaches and applications of computational biomechanics, from researchers in Australia, New Zealand, USA, France, Spain and Switzerland. Some of the interesting topics discussed are:real-time simulations; growth and remodelling of soft tissues; inverse and meshless solutions; medical image analysis; and patient-specific solid mechanics simulations.One of the greatest challenges facing the computational engineering community is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, the biomedical sciences, and medicine. We hope the research presented within this book series will contribute to overcoming this grand challenge.

Published
2015

9. Computational Biomechanics for Medicine : Fundamental Science and Patient-specific Applications

Author

Barry Doyle, Karol Miller, Adam Wittek, Poul M.F. Nielsen, Barry Doyle, Karol Miller, Adam Wittek, and Poul M.F. Nielsen

Subjects
Biomedical engineering, Medicine--Data processing, Biomedical engineering--Data processing
Abstract

One of the greatest challenges facing the computational engineering community is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, the biomedical sciences and medicine. The Computational Biomechanics for Medicine series provides an opportunity for specialists in computational biomechanics to present their latest methodologies and advancements. This 5th edition comprises nine of the latest developments in both fundamental science and patient-specific applications, from researchers in Australia, New Zealand, USA, UK, France, Ireland and China. Some of the interesting topics discussed are: cellular mechanics; tumor growth and modeling; medical image analysis and both patient-specific fluid dynamics and solid mechanic simulations.

Published
2014

10. Computational Biomechanics for Medicine : Models, Algorithms and Implementation

Author

Adam Wittek, Karol Miller, Poul M.F. Nielsen, Adam Wittek, Karol Miller, and Poul M.F. Nielsen

Subjects
Biological models, Biomedical engineering, Biomechanics--Mathematical models--Congresses, Biomedical engineering--Mathematical models--Congresses
Abstract

One of the greatest challenges for mechanical engineers is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, biomedical sciences, and medicine. This book is an opportunity for computational biomechanics specialists to present and exchange opinions on the opportunities of applying their techniques to computer-integrated medicine.Computational Biomechanics for Medicine: Models, Algorithms and Implementation collects the papers from the Seventh Computational Biomechanics for Medicine Workshop held in Nice in conjunction with the Medical Image Computing and Computer Assisted Intervention conference. The topics covered include: medical image analysis, image-guided surgery, surgical simulation, surgical intervention planning, disease prognosis and diagnostics, injury mechanism analysis, implant and prostheses design, and medical robotics.

Published
2013

11. Computational Biomechanics for Medicine : Deformation and Flow

Author

Poul M.F. Nielsen, Adam Wittek, Karol Miller, Poul M.F. Nielsen, Adam Wittek, and Karol Miller

Subjects
Biological models, Biomedical engineering, Biomedical engineering--Data processing--Congresses, Medicine--Data processing--Congresses, Medical personnel, Mathematical models, Engineering
Abstract

One of the greatest challenges for mechanical engineers is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, biomedical sciences, and medicine. This book is an opportunity for computational biomechanics specialists to present and exchange opinions on the opportunities of applying their techniques to computer-integrated medicine.Computational Biomechanics for Medicine: Deformation and Flow collects the papers from the Medical Image Computing and Computer Assisted Intervention conference (MICCAI 2011) dedicated to research in the field of medical image computing and computer assisted medical interventions. The topics covered include: medical image analysis, image-guided surgery, surgical simulation, surgical intervention planning, disease prognosis and diagnostics, injury mechanism analysis, implant and prostheses design, and medical robotics.

Published
2012

12. Computational Biomechanics for Medicine : Soft Tissues and the Musculoskeletal System

Author

Adam Wittek, Poul M.F. Nielsen, Karol Miller, Adam Wittek, Poul M.F. Nielsen, and Karol Miller

Subjects
Biomedical engineering, Biophysics, Biomaterials, Engineering mathematics, Engineering—Data processing, Mechanics, Applied, Solids, Surgery
Abstract

One of the greatest challenges for mechanists is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, biomedical sciences, and medicine. The proposed workshop will provide an opportunity for computational biomechanics specialists to present and exchange opinions on the opportunities of applying their techniques to computer-integrated medicine.These are peer-reviewed proceedings of the workshop affiliated to a major international research conference (Medical Image Computing and Computer Assisted Intervention MICCAI 2010 in Beijing) dedicated to research in the field of medical image computing and computer assisted medical interventions. The list of subjects covered include: medical image analysis, image-guided surgery, surgical simulation, surgical intervention planning, disease prognosis and diagnostics, injury mechanism analysis, implant and prostheses design, medical robotics.

Published
2011

14. CellML and associated tools and techniques.

Author

Alan Garny, David P. Nickerson, Jonathan Cooper, Rodrigo Weber dos Santos, Andrew K. Miller, Steve McKeever, Poul M.F. Nielsen, and Peter J. Hunter

Subjects
COMPUTER simulation, MORPHOLOGY, HUMAN body, PHYSICAL biochemistry
Abstract

We have, in the last few years, witnessed the development and availability of an ever increasing number of computer models that describe complex biological structures and processes. The multi-scale and multi-physics nature of these models makes their development particularly challenging, not only from a biological or biophysical viewpoint but also from a mathematical and computational perspective. In addition, the issue of sharing and reusing such models has proved to be particularly problematic, with the published models often lacking information that is required to accurately reproduce the published results.The International Union of Physiological Sciences Physiome Project was launched in 1997 with the aim of tackling the aforementioned issues by providing a framework for the modelling of the human body. As part of this initiative, the specifications of the CellML mark-up language were released in 2001.Now, more than 7 years later, the time has come to assess the situation, in particular with regard to the tools and techniques that are now available to the modelling community. Thus, after introducing CellML, we review and discuss existing editors, validators, online repository, code generators and simulation environments, as well as the CellML Application Program Interface. We also address possible future directions including the need for additional mark-up languages. [ABSTRACT FROM AUTHOR]

Published
2008
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