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143 results on '"Pott, Sebastian"'

1. A Roadmap for the Human Gut Cell Atlas

Author

Zilbauer, Matthias, James, Kylie R., Kaur, Mandeep, Pott, Sebastian, Li, Zhixin, Burger, Albert, Thiagarajah, Jay R., Burclaff, Joseph, Jahnsen, Frode L., Perrone, Francesca, Ross, Alexander D., Matteoli, Gianluca, Stakenborg, Nathalie, Sujino, Tomohisa, Moor, Andreas, Bartolome-Casado, Raquel, Bækkevold, Espen S., Zhou, Ran, Xie, Bingqing, Lau, Ken S., Din, Shahida, Magness, Scott T., Yao, Qiuming, Beyaz, Semir, Arends, Mark, Denadai-Souza, Alexandre, Coburn, Lori A., Gaublomme, Jellert T., Baldock, Richard, Papatheodorou, Irene, Ordovas-Montanes, Jose, Boeckxstaens, Guy, Hupalowska, Anna, Teichmann, Sarah A., Regev, Aviv, Xavier, Ramnik J., Simmons, Alison, Snyder, Michael P., and Wilson, Keith T.

Published
2023
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6. Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages

Author

Rowton, Megan, Perez-Cervantes, Carlos, Hur, Suzy, Jacobs-Li, Jessica, Lu, Emery, Deng, Nikita, Guzzetta, Alexander, Hoffmann, Andrew D., Stocker, Matthew, Steimle, Jeffrey D., Lazarevic, Sonja, Oubaha, Sophie, Yang, Xinan H., Kim, Chul, Yu, Shuhan, Eckart, Heather, Koska, Mervenaz, Hanson, Erika, Chan, Sunny S.K., Garry, Daniel J., Kyba, Michael, Basu, Anindita, Ikegami, Kohta, Pott, Sebastian, and Moskowitz, Ivan P.

Published
2022
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7. Hedgehog–FGF signaling axis patterns anterior mesoderm during gastrulation

Author

Guzzetta, Alexander, Koska, Mervenaz, Rowton, Megan, Sullivan, Kaelan R., Jacobs-Li, Jessica, Kweon, Junghun, Hidalgo, Hunter, Eckart, Heather, Hoffmann, Andrew D., Back, Rebecca, Lozano, Stephanie, Moon, Anne M., Basu, Anindita, Bressan, Michael, Pott, Sebastian, and Moskowitz, Ivan P.

Published
2020

8. Bile acid fitness determinants of a Bacteroides fragilis isolate from a human pouchitis patient

Author

Fiebig, Aretha, primary, Schnizlein, Matthew K., additional, Pena-Rivera, Selymar, additional, Trigodet, Florian, additional, Dubey, Abhishek Anil, additional, Hennessy, Miette K., additional, Basu, Anindita, additional, Pott, Sebastian, additional, Dalal, Sushila, additional, Rubin, David, additional, Sogin, Mitchell L., additional, Eren, A. Murat, additional, Chang, Eugene B., additional, and Crosson, Sean, additional

Published
2023
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9. Multiomic analysis reveals cellular and epigenetic plasticity in intestinal pouches of ulcerative colitis patients

Author

Zhao, Yu, primary, Zhou, Ran, additional, Xie, Bingqing, additional, Liu, Cambrian Y, additional, Kalski, Martin, additional, Cham, Candace M, additional, Koval, Jason, additional, Weber, Christopher R, additional, Rubin, David T, additional, Sogin, Mitch, additional, Crosson, Sean, additional, Huang, Jun, additional, Fiebig, Aretha, additional, Dalal, Sushila, additional, Chang, Eugene B, additional, Basu, Anindita, additional, and Pott, Sebastian, additional

Published
2023
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10. Untangling the Role of Pathobionts from Bacteroides Species in Inflammatory Bowel Diseases

Author

Shan, Yue, primary, Lake, Joash, additional, Cham, Candace M., additional, Zhu, Mingming, additional, Kaur, Deepinder, additional, Ringus, Daina, additional, Fei, Na, additional, Weber, Christopher R., additional, Spedale, Melanie, additional, Theriault, Betty, additional, Dalal, Sushila, additional, Rubin, David T., additional, Fiebig, Aretha, additional, Crosson, Sean, additional, Lolans, Karen, additional, Comstock, Laurie, additional, Eren, A. Murat, additional, Basu, Anindita, additional, Pott, Sebastian, additional, Sogin, Mitchell, additional, Liu, Cambrian, additional, and Chang, Eugene B., additional

Published
2023
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12. Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production

Author

Perrault, Ella N., primary, Shireman, Jack M., additional, Ali, Eunus S., additional, Lin, Peiyu, additional, Preddy, Isabelle, additional, Park, Cheol, additional, Budhiraja, Shreya, additional, Baisiwala, Shivani, additional, Dixit, Karan, additional, James, C. David, additional, Heiland, Dieter H, additional, Ben-Sahra, Issam, additional, Pott, Sebastian, additional, Basu, Anindita, additional, Miska, Jason, additional, and Ahmed, Atique U., additional

Published
2023
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13. Bile acid fitness determinants of aBacteroides fragilisisolate from a human pouchitis patient

Author

Fiebig, Aretha, primary, Schnizlein, Matthew K., additional, Pena-Rivera, Selymar, additional, Trigodet, Florian, additional, Dubey, Abhishek Anil, additional, Hennessy, Miette, additional, Basu, Anindita, additional, Pott, Sebastian, additional, Dalal, Sushila, additional, Rubin, David, additional, Sogin, Mitchell L., additional, Eren, A. Murat, additional, Chang, Eugene B., additional, and Crosson, Sean, additional

Published
2023
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15. Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2

Author

Malik, Vikas, Glaser, Laura V., Zimmer, Dennis, Velychko, Sergiy, Weng, Mingxi, Holzner, Markus, Arend, Marius, Chen, Yanpu, Srivastava, Yogesh, Veerapandian, Veeramohan, Shah, Zahir, Esteban, Miguel A., Wang, Huating, Chen, Jiekai, Schöler, Hans R., Hutchins, Andrew P., Meijsing, Sebastiaan H., Pott, Sebastian, and Jauch, Ralf

Published
2019
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18. DDDR-21. REGULATORY REDUCTASE SUBUNIT RRM2 AND DEHYDROGENASE IMPDH2 INTERACT IN GLIOBLASTOMA IN A TMZ-DEPENDENT MANNER

Author

McManus, Graysen, primary, Perrault, Ella, additional, Shireman, Jack, additional, Ventarapragada, Divya, additional, Lahmadi, Linna, additional, Lin, Peiyu, additional, Ali, Eunis, additional, Park, Cheol, additional, Baisiwala, Shivani, additional, James, David, additional, Ben-Sahra, Issam, additional, Pott, Sebastian, additional, Basu, Anindita, additional, Miska, Jason, additional, and Ahmed, Atique, additional

Published
2022
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23. Ribonucleotide Reductase Regulatory Subunit M2 as a Driver of Glioblastoma TMZ-Resistance through Modulation of dNTP Production

Author

Perrault, Ella N, primary, Shireman, Jack M, additional, Ali, Eunus S, additional, Preddy, Isabelle, additional, Lin, Peiyu, additional, Park, Cheol, additional, Tomes, Luke, additional, Zolp, Andrew J, additional, Budhiraja, Shreya, additional, Baisiwala, Shivani, additional, James, Charles David, additional, Ben-Sahra, Issam, additional, Pott, Sebastian, additional, Basu, Anindita, additional, and Ahmed, Atique U, additional

Published
2021
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24. DDRE-34. RIBONUCLEOTIDE REDUCTASE REGULATORY SUBUNIT M2 AS A DRIVER OF GLIOBLASTOMA TMZ-RESISTANCE THROUGH MODULATION OF dNTP PRODUCTION

Author

Perrault, Ella, primary, Shireman, Jack, additional, Lin, Peiyu, additional, Ali, Eunus, additional, Zolp, Andrew, additional, Budhiraja, Shreya, additional, Park, Cheol, additional, Baisiwala, Shivani, additional, James, David, additional, Ben-Sahra, Issam, additional, Pott, Sebastian, additional, Basu, Anindita, additional, and Ahmed, Atique, additional

Published
2021
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29. Sa1797 SINGLE-CELL GENE EXPRESSION AND CHROMATIN ACCESSIBILITY PROFILING REVEALS PROFOUND CELLULAR AND EPIGENETIC PLASTICITY OF INTESTINAL POUCHES FROM ULCERATIVE COLITIS PATIENTS

Author

Zhao, Yu, Zhou, Ran, Xie, Bingqing, Liu, Cambrian Y., Cham, Candace M., Koval, Jason, Kalski, Martin, Rubin, David T., Huang, Jun, Sogin, Mitch, Weber, Christopher, Fiebig, Aretha, Crosson, Sean, Dalal, Sushila, Chang, Eugene B., Basu, Anindita, and Pott, Sebastian

Published
2023
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40. A Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation

Author

Guzzetta, Alexander, primary, Koska, Mervenaz, additional, Rowton, Megan, additional, Kweon, Junghun, additional, Hidalgo, Hunter, additional, Eckhart, Heather, additional, Back, Rebecca, additional, Lozano, Stephanie, additional, Moon, Anne M., additional, Basu, Anindita, additional, Bressan, Michael, additional, Pott, Sebastian, additional, and Moskowitz, Ivan P., additional

Published
2019
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42. Systematic Comparison of High-throughput Single-Cell and Single-Nucleus Transcriptomes during Cardiomyocyte Differentiation

Author

Selewa, Alan, primary, Dohn, Ryan, additional, Eckart, Heather, additional, Lozano, Stephanie, additional, Xie, Bingqing, additional, Gauchat, Eric, additional, Elorbany, Reem, additional, Rhodes, Katherine, additional, Burnett, Jonathan, additional, Gilad, Yoav, additional, Pott, Sebastian, additional, and Basu, Anindita, additional

Published
2019
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45. Hedgehog signaling activates a heterochronic gene regulatory network to control differentiation timing across lineages

Author

Rowton, Megan, primary, Perez-Cervantes, Carlos, additional, Rydeen, Ariel, additional, Hur, Suzy, additional, Jacobs-Li, Jessica, additional, Deng, Nikita, additional, Lu, Emery, additional, Guzzetta, Alexander, additional, Steimle, Jeffrey D., additional, Hoffmann, Andrew, additional, Lazarevic, Sonja, additional, Yang, Xinan Holly, additional, Kim, Chul, additional, Yu, Shuhan, additional, Eckart, Heather, additional, Iddir, Sabrina, additional, Koska, Mervenaz, additional, Hanson, Erika, additional, Chan, Sunny Sun-Kin, additional, Garry, Daniel J., additional, Kyba, Michael, additional, Basu, Anindita, additional, Ikegami, Kohta, additional, Pott, Sebastian, additional, and Moskowitz, Ivan P., additional

Published
2018
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46. Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice

Author

Chappell, Grace A., Israel, Jennifer W., Simon, Jeremy M., Pott, Sebastian, Safi, Alexias, Eklund, Karl, Sexton, Kenneth G., Bodnar, Wanda, Lieb, Jason D., Crawford, Gregory E., Rusyn, Ivan, and Furey, Terrence S.

Subjects
Chemical carcinogenesis -- Research, Cancer genetics -- Research, DNA damage -- Research, Environmental toxicology -- Research, Chromatin -- Research, Transcription (Genetics) -- Research, Butadiene -- Health aspects, Environmental issues, Health
Abstract

BACKGROUND: The damaging effects of exposure to environmental toxicants differentially affect genetically distinct individuals, but the mechanisms contributing to these differences are poorly understood. Genetic variation affects the establishment of the gene regulatory landscape and thus gene expression, and we hypothesized that this contributes to the observed heterogeneity in individual responses to exogenous cellular insults. OBJECTIVES: We performed an in vivo study of how genetic variation and chromatin organization may dictate susceptibility to DNA damage, and influence the cellular response to such damage, caused by an environmental toxicant. MATERIALS AND METHODS: We measured DNA damage, messenger RNA (mRNA) and microRNA (miRNA) expression, and genome-wide chromatin accessibility in lung tissue from two genetically divergent inbred mouse strains, C57BL/6J and CAST/EiJ, both in unexposed mice and in mice exposed to a model DNA-damaging chemical, 1,3-butadiene. RESULTS: Our results showed that unexposed CAST/EiJ and C57BL/6J mice have very different chromatin organization and transcription profiles in the lung. Importantly, in unexposed CAST/EiJ mice, which acquired relatively less 1,3-butadiene-induced DNA damage, we observed increased transcription and a more accessible chromatin landscape around genes involved in detoxification pathways. Upon chemical exposure, chromatin was significantly remodeled in the lung of C57BL/6J mice, a strain that acquired higher levels of 1,3-butadiene-induced DNA damage, around the same genes, ultimately resembling the molecular profile of CAST/EiJ. CONCLUSIONS: These results suggest that strain-specific changes in chromatin and transcription in response to chemical exposure lead to a 'compensation' for underlying genetic-driven interindividual differences in the baseline chromatin and transcriptional state. This work represents an example of how chemical and environmental exposures can be evaluated to better understand gene-by-environment interactions, and it demonstrates the important role of chromatin response in transcriptomic changes and, potentially, in deleterious effects of exposure. https://doi.org/10.1289/EHP1937, Introduction Inter-individual genetic variation can have profound impacts on the metabolism of pharmaceutical drugs and environmental toxicants (Ma and Lu 2011; Pierce et al. 2012). The molecular consequences of chemical [...]

Published
2017
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