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177 results on '"Potoski, Brian A."'

1. Stewardship-guided T2Candida testing shortens time to antifungal treatment and reduces antifungal usage among medical ICU patients with septic shock

Author

O’Donnell, Matt, primary, Shields, Ryan K, additional, Marini, Rachel V, additional, Groetzinger, Lara M, additional, Potoski, Brian A, additional, Falcione, Bonnie A, additional, Shah, Sunish, additional, McCreary, Erin K, additional, Clarke, Lloyd, additional, Brant, Emily, additional, McVerry, Bryan J, additional, Liegey, Susan, additional, Pasculle, A William, additional, Clancy, Cornelius J, additional, and Nguyen, M Hong, additional

Published
2023
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6. Stewardship-Guided T2Candida Testing Shortens Time to Antifungal Treatment and Reduces Antifungal Usage Among Medical Intensive Care Unit Patients With Septic Shock.

Author

O'Donnell, Matthew, Shields, Ryan K, Marini, Rachel V, Groetzinger, Lara M, Potoski, Brian A, Falcione, Bonnie A, Shah, Sunish, McCreary, Erin K, Clarke, Lloyd, Brant, Emily, McVerry, Bryan J, Liegey, Susan, Pasculle, A William, Clancy, Cornelius J, and Nguyen, M Hong

Subjects
INTENSIVE care patients, SEPTIC shock, MEDICAL care, CANDIDEMIA, INVASIVE candidiasis, INTENSIVE care units
Abstract

Background Diagnosis of invasive candidiasis (IC) is limited by insensitivity and slow turnaround of cultures. Our objectives were to define the performance of T2Candida, a nonculture test, under guidance of a diagnostic stewardship program, and evaluate impact on time to antifungal initiation and antifungal utilization. Methods This was a retrospective study of adult medical intensive care unit (MICU) patients with septic shock for whom T2Candida testing was performed from March 2017 to March 2020. Patients with positive T2Candida results during this period were compared to MICU patients who did not undergo T2Candida testing but had septic shock and blood cultures positive for Candida from January 2016 through March 2020. Results Overall, 155 T2Candida tests from 143 patients were included. Nine percent of T2Candida tests were positive compared to 4.5% of blood cultures. Sensitivity, specificity, positive predictive value, and negative predictive value of T2Candida for proven and probable IC were 78%, 95%, 50%, and 99%, respectively. Patients who tested positive for T2Candida (n = 14) were diagnosed earlier and initiated on antifungal therapy sooner than patients with IC (n = 14) diagnosed by blood culture alone (median, 5.6 vs 60 hours; P <.0001). Median antifungal days of therapy/1000 patient-days were 23.3/month preimplementation and 15/month postimplementation (P   =.007). Following a negative T2Candida result, empiric antifungals were either not administered in 58% or discontinued within 72 hours in 96% of patients. Conclusions Diagnostic stewardship guided T2Candida testing resulted in reduced time to IC diagnosis, faster initiation of antifungal therapy, and lower antifungal usage among MICU patients with septic shock. [ABSTRACT FROM AUTHOR]

Published
2023
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8. 916. Increased efficiency and impact of implementing ILUM insight within an antimicrobial stewardship program (ASP) at an academic medical center

Author

Shields, Ryan K, primary, Marini, Rachel V, additional, Shah, Sunish, additional, Falcione, Bonnie A, additional, Potoski, Brian A, additional, Liu, Leanna, additional, Goshorn, Eli S, additional, Clarke, Lloyd, additional, Viehman, Alex, additional, Hadi, Christiane, additional, Kwak, Eun Jeong, additional, Samanta, Palash, additional, Khadem, Tina, additional, Ryan Bariola, J, additional, Yakemowicz, Caley, additional, Simonick, Courtney, additional, Erwee, Riaan, additional, McCreary, Erin K, additional, Abdel-Massih, Rima, additional, and Nguyen, Minh-Hong, additional

Published
2022
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14. Control of an outbreak of infection with the hypervirulent Clostridium difficile BI strain in a university hospital using a comprehensive 'bundle' approach

Author

Muto, Carlene A., Blank, Mary Kathleen, Marsh, Jane W., Vergis, Emanuel N., O'Leary, Mary M., Shutt, Kathleen A., Pasculle, Anthony W., Pokrywka, Marian, Garcia, Juliet G., Posey, Kathy, Roberts, Terri L., Potoski, Brian A., Blank, Gary E., Simmons, Richard L., Veldkamp, Peter, Harrison, Lee H., and Paterson, David L.

Subjects
Epidemics -- Pennsylvania, Epidemics -- Control, Epidemics -- Research, Clostridium difficile -- Health aspects, Clostridium difficile -- Care and treatment, Clostridium difficile -- Prevention, Hospitals, University -- Services, Health, Health care industry
Published
2007

15. Epidemiological profile of linezolid-resistant coagulase-negative staphylococci

Author

Potoski, Brian A., Adams, Jennifer, Clarke, Lloyd, Shutt, Kathleen, Linden, Peter K., Baxter, Carla, Pasculle, A. William, Capitano, Blair, Peleg, Anton Y., Szabo, Dora, and Paterson, David L.

Subjects
Linezolid -- Complications and side effects, Linezolid -- Research, Staphylococcus -- Physiological aspects, Staphylococcus -- Analysis, Drug resistance in microorganisms -- Research, Health, Health care industry
Published
2006

17. Measurement of adherence to antiretroviral medications

Author

Paterson, David L., Potoski, Brian, and Capitano, Blair

Subjects
Epidemiology -- Statistics, Epidemiology -- Research, HIV patients -- Health aspects, HIV patients -- Care and treatment, HIV infection -- Health aspects, HIV infection -- Prevention, HIV infection -- Research, Antiviral agents -- Physiological aspects, AIDS (Disease) -- Research, Health
Abstract

Research has been conducted on adherence to antiretroviral therapy. Results demonstrate that adherene measurement is important in the assessment of the patients who fail to respond to antiretroviral therapy.

Published
2002

25. Extensively drug-resistant Acinetobacter baumannii

Author

Doi, Yohei, Husain, Shahid, Potoski, Brian A., McCurry, Kenneth R., and Paterson, David L.

Subjects
Gram-negative bacteria -- Health aspects, Gram-negative bacteria -- Genetic aspects, Gram-negative bacteria -- Control, Gram-negative bacteria -- Research, Drug resistance in microorganisms -- Health aspects, Drug resistance in microorganisms -- Research
Abstract

To the Editor: In the 1990s, patients infected with vancomycin-resistant Enterococcus faecium were successfully treated with new antimicrobial drugs. However, it is unlikely that new antimicrobial drugs will be available [...]

Published
2009

28. 247. Sustaining Excellence of Care During a Fluid Shortage: Snapshot of Antibiotic Mitigation Strategies Following Hurricane Maria

Author

Marini, Rachel V, primary, Potoski, Brian A, additional, Wilson, William R, additional, Falcione, Bonnie, additional, Clarke, Lloyd, additional, L’Altrelli, Alfred, additional, Khadem, Tina, additional, Shields, Ryan K, additional, Clancy, Cornelius J, additional, Nguyen, M Hong, additional, Gross, Paige, additional, Viehman, J Alexander, additional, and Then, Janine, additional

Published
2018
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31. Clinical and Economic Comparison of Ceftaroline Fosamil (CPT) and Daptomycin (DAP) for Methicillin-Resistant Staphylococcus aureus (MRSA) Bloodstream Infections (BSI)

Author

Zasowski, Evan J, primary, Trinh, Trang D, additional, Claeys, Kimberly, additional, Lagnf, Abdalhamid M, additional, Klinker, Kenneth, additional, Estrada, Sandy, additional, Davis, Susan L, additional, Huang, Vanthida, additional, Potoski, Brian A, additional, Levine, Donald, additional, Kaye, Keith S, additional, Bonine, Nicole, additional, Gillard, Patrick, additional, and Rybak, Michael J, additional

Published
2017
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32. Evaluation of the In Vitro Activity of Ceftazidime-Avibactam and Ceftolozane-Tazobactam against Meropenem-Resistant Pseudomonas aeruginosa Isolates

Author

Buehrle, Deanna J., primary, Shields, Ryan K., additional, Chen, Liang, additional, Hao, Binghua, additional, Press, Ellen G., additional, Alkrouk, Ammar, additional, Potoski, Brian A., additional, Kreiswirth, Barry N., additional, Clancy, Cornelius J., additional, and Nguyen, M. Hong, additional

Published
2016
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35. Doripenem MICs and ompK36 Porin Genotypes of Sequence Type 258, KPC-Producing Klebsiella pneumoniae May Predict Responses to Carbapenem-Colistin Combination Therapy among Patients with Bacteremia

Author

Shields, Ryan K., primary, Nguyen, M. Hong, additional, Potoski, Brian A., additional, Press, Ellen G., additional, Chen, Liang, additional, Kreiswirth, Barry N., additional, Clarke, Lloyd G., additional, Eschenauer, Gregory A., additional, and Clancy, Cornelius J., additional

Published
2015
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36. Clinical failures of linezolid and implications for the clinical microbiology laboratory. (Commentary)

Author

Potoski, Brian A., Mangino, Julie E., and Goff, Debra A.

Subjects
Anti-infective agents -- Evaluation, Anti-infective agents -- Testing, Mandatory drug testing -- Evaluation, Gram-positive bacterial infections -- Care and treatment
Abstract

Linezolid is the first in a new class of antimicrobials, the oxazolidinones. This antimicrobial is approved to treat gram-positive infections caused by vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) [...]

Published
2002

37. Dosing Practices of Intravenous Acyclovir for Herpes Encephalitis in Obesity: Results of a Pharmacist Survey.

Author

Wong, Adrian, Pickering, Aaron J., and Potoski, Brian A.

Subjects
ACADEMIC medical centers, ACYCLOVIR, INTRAVENOUS therapy, OBESITY, PHARMACEUTICAL arithmetic, PHARMACISTS, SURVEYS, BODY mass index, DESCRIPTIVE statistics, VIRAL encephalitis
Abstract

Background: Dosing of intravenous acyclovir for herpes encephalitis in obese patients is recommended to be based on ideal body weight. However, limited data support this recommendation, and recent data suggest this may lead to underdosing. Objective: To determine national dosing practices of intravenous acyclovir across a range of patient weights. Methods: A survey was distributed to members of the American College of Clinical Pharmacy Critical Care and Infectious Diseases Practice & Research Networks listservs. Data collected included demographic information and dosing of acyclovir, given consistent patient cases with varying patient weight. Results: A total of 264 pharmacists participated in the survey, with 240 (90.9%) participants completing the survey. Participants were predominately clinical pharmacists. As patient weight increased, respondents were more apt to dose based on an adjusted body weight, with dosing in the obese and morbidly obese showing a clear lack of consistency. Conclusions: Intravenous dosing of acyclovir for herpes encephalitis is variable, especially in obese patients, and does not reflect recommendations. Limited data provide conflicting recommendations for dosing in obese patients, and future studies are necessary to optimize patient outcomes and prevent toxicity. [ABSTRACT FROM AUTHOR]

Published
2017
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38. Real-World Experience with Echinocandin MICs against Candida Species in a Multicenter Study of Hospitals That Routinely Perform Susceptibility Testing of Bloodstream Isolates

Author

Eschenauer, Gregory A., primary, Nguyen, M. Hong, additional, Shoham, Shmuel, additional, Vazquez, Jose A., additional, Morris, Arthur J., additional, Pasculle, William A., additional, Kubin, Christine J., additional, Klinker, Kenneth P., additional, Carver, Peggy L., additional, Hanson, Kimberly E., additional, Chen, Sharon, additional, Lam, Simon W., additional, Potoski, Brian A., additional, Clarke, Lloyd G., additional, Shields, Ryan K., additional, and Clancy, Cornelius J., additional

Published
2014
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40. Multicenter Study of High-Dose Daptomycin for Treatment of Enterococcal Infections

Author

Casapao, Anthony M., primary, Kullar, Ravina, additional, Davis, Susan L., additional, Levine, Donald P., additional, Zhao, Jing J., additional, Potoski, Brian A., additional, Goff, Debra A., additional, Crank, Christopher W., additional, Segreti, John, additional, Sakoulas, George, additional, Cosgrove, Sara E., additional, and Rybak, Michael J., additional

Published
2013
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43. High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen

Author

Shields, Ryan K., primary, Kwak, Eun J., additional, Potoski, Brian A., additional, Doi, Yohei, additional, Adams-Haduch, Jennifer M., additional, Silviera, Fernanda P., additional, Toyoda, Yoshiya, additional, Pilewski, Joseph M., additional, Crespo, Maria, additional, Pasculle, A. William, additional, Clancy, Cornelius J., additional, and Nguyen, M. Hong, additional

Published
2011
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