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Ovalbumin (OVA), the most abundant protein in egg whites, has been widely used in various industries. Currently, the structure of OVA has been clearly established, and the extraction of high-purified OVA has become feasible. However, the allergenicity of OVA is still a serious problem because it can cause severe allergic reactions and may even be life-threatening. The structure and allergenicity of the OVA can be altered by many processing methods. In this article, a detailed description on the structure and a comprehensive overview on the extraction protocols and the allergenicity of OVA was documented. Additionally, the information on assembly and potential applications of OVA was summarized and discussed in detail. Physical treatment, chemical modification, and microbial processing can be applied to alter the IgE-binding capacity of OVA by changing its structure and linear/sequential epitopes. Furthermore, research indicated that OVA could assemble with itself or other biomolecules into various forms (particles, fibers, gels, and nanosheets), which expanded its application in the food field. OVA also shows excellent application prospects, including food preservation, functional food ingredients and nutrient delivery. Therefore, OVA demonstrates significant investigation value as a food grade ingredient. [ABSTRACT FROM AUTHOR]

Abstract Chronic hepatitis B poses a significant global burden, modulating immune cells, leading to chronic inflammation and long-term damage. Due to its hepatotropism, the hepatitis B virus (HBV) cannot infect other cells. The mechanisms underlying the intercellular communication among different liver cells in HBV-infected individuals and the immune microenvironment imbalance remain elusive. Exosomes, as important intercellular communication and cargo transportation tools between HBV-infected hepatocytes and immune cells, have been shown to assist in HBV cargo transportation and regulate the immune microenvironment. However, the role of exosomes in hepatitis B has only gradually received attention in recent years. Minimal literature has systematically elaborated on the role of exosomes in reshaping the immune microenvironment of the liver. This review unfolds sequentially based on the biological processes of exosomes: exosomes’ biogenesis, release, transport, uptake by recipient cells, and their impact on recipient cells. We delineate how HBV influences the biogenesis of exosomes, utilizing exosomal covert transmission, and reshapes the hepatic immune microenvironment. And based on the characteristics and functions of exosomes, potential applications of exosomes in hepatitis B are summarized and predicted. Graphical Abstract

Chronic hepatitis B poses a significant global burden, modulating immune cells, leading to chronic inflammation and long-term damage. Due to its hepatotropism, the hepatitis B virus (HBV) cannot infect other cells. The mechanisms underlying the intercellular communication among different liver cells in HBV-infected individuals and the immune microenvironment imbalance remain elusive. Exosomes, as important intercellular communication and cargo transportation tools between HBV-infected hepatocytes and immune cells, have been shown to assist in HBV cargo transportation and regulate the immune microenvironment. However, the role of exosomes in hepatitis B has only gradually received attention in recent years. Minimal literature has systematically elaborated on the role of exosomes in reshaping the immune microenvironment of the liver. This review unfolds sequentially based on the biological processes of exosomes: exosomes' biogenesis, release, transport, uptake by recipient cells, and their impact on recipient cells. We delineate how HBV influences the biogenesis of exosomes, utilizing exosomal covert transmission, and reshapes the hepatic immune microenvironment. And based on the characteristics and functions of exosomes, potential applications of exosomes in hepatitis B are summarized and predicted. [ABSTRACT FROM AUTHOR]

Curcumol (Cur), a guaiane-type sesquiterpenoid hemiketal, is an important and representative bioactive component extracted from the essential oil of the rhizomes of Curcumae rhizoma which is also known as "Ezhu" in traditional Chinese medicine. Recently, Cur has received considerable attention from the research community due to its favorable pharmacological activities, including anti-cancer, hepatoprotective, anti-inflammatory, anti-viral, anti-convulsant, and other activities, and has also exerted therapeutic effect on various cancers, liver diseases, inflammatory diseases, and infectious diseases. Pharmacokinetic studies have shown that Cur is rapidly distributed in almost all organs of rats after intragastric administration with high concentrations in the small intestine and colon. Several studies focusing on structure–activity relationship (SAR) of Cur have shown that some Cur derivatives, chemically modified at C-8 or C-14, exhibited more potent anti-cancer activity and lower toxicity than Cur itself. This review aims to comprehensively summarize the latest advances in the pharmacological and pharmacokinetic properties of Cur in the last decade with a focus on its anti-cancer and hepatoprotective potentials, as well as the research progress in drug delivery system and potential applications of Cur to date, to provide researchers with the latest information, to highlighted the limitations of relevant research at the current stage and the aspects that should be addressed in future research. Our results indicate that Cur and its derivatives could serve as potential novel agents for the treatment of a variety of diseases, particularly cancer and liver diseases. [ABSTRACT FROM AUTHOR]

Rice protein, a high-quality protein, contains all of its essential amino acids, and its amino acid composition is consistent with the ideal pattern recommended by the Food and Agriculture Organization/World Health Organization. Rice protein-derived products as feed additives have rather low added value. Rice protein hydrolysates (RPHs) are valuable products that can be generated from underutilized rice protein. In the RPH, oligopeptide-enriched RPH and its oligopeptides have been proposed as superior candidates for improving absorption and bioavailability and have potential broad application. Thus, this review outlines the absorption behavior, bioactivity, and preparation of rice oligopeptides. The structure-bitterness relationships and debittering of these materials are discussed in detail, as are their safety and allergenicity. Additionally, the applications of rice oligopeptides in the food and pharmaceutical industries as functional ingredients are also highlighted. [ABSTRACT FROM AUTHOR]

Despite their importance to global economies, the aquaculture and seafood sectors are major contributors to waste, which is a problem for the environment. Because of its biocompatibility and recyclability, fish waste, which is rich in chitin and chitosan—holds potential in several fields. The shells of crustaceans are the source of chitin and chitosan, two substances with versatile and useful qualities. Although it is not very soluble, chitin is very biocompatible and biodegradable, much like cellulose. The more versatile and solubilized chitosan is made when chitin is deacetylated. About half of seafood waste is made up of cephalothoraxes and shrimp exoskeletons, and chitin is the second most common polysaccharide in the world. An eco‐friendly strategy for managing seafood waste and creating value may be found in investigating these compounds originating from the ocean. The byproduct of fish scales, chitosan, has many uses in the cosmetics, pharmaceutical, culinary, and aquaculture industries. Greener ways of chitin extraction include enzymatic deproteinization and microbial fermentations, as well as biological approaches like demineralization and deproteinization. Chitosan has several potential uses in biomedicine, food technology, and tissue engineering because of its acid solubility and precipitation at pH values greater than 6.0. It may be used in wound healing, water treatment, and agriculture due to its biocompatibility, biodegradability, and antibacterial qualities. Research on chitosan supplementation in several fish species suggests that it may improve immune responses. However, further research is needed to properly comprehend this. Oral chitosan use has the potential to lead to a more efficient and environmentally friendly aquaculture industry. [ABSTRACT FROM AUTHOR]

Due to their excellent reliability, low cost, and environmental friendliness, aqueous Zn‐ion batteries (AZIBs) present a promising prospect for both mobile and stationary energy storage for smart devices and cities. However, current challenges, such as anode dendrite growth, cathode dissolution, and parasitic side reactions, hinder the practical application of AZIBs. This review first provides an in‐depth explanation of the energy storage mechanisms of anodes and cathodes. A comprehensive discussion of typical issues with the anode, cathode, and electrolyte of AZIBs is then presented. Furthermore, the practical considerations and potential applications in the development of smart flexible electronics are illustrated. Finally, the challenges and perspectives for the future development of practical AZIBs are highlighted. This review is expected to serve as a guidepost for the practical applications of AZIBs for clean, sustainable, and efficient energy storage and management in new urban forms. [ABSTRACT FROM AUTHOR]

ABSTRACTSince carbon (C) atom has a variety of chemical bonds via hybridization between s and p atomic orbitals, it is well known that there are robust carbon materials. In particular, discovery of C60 has been an epoch making to cultivate nanocarbon fields. Since then, nanocarbon materials such as nanotube and graphene have been reported. It is interesting to note that C60 is soluble and volatile unlike nanotube and graphene. This indicates that C60 film is easy to be produced on any kinds of substrates, which is advantage for device fabrication. In particular, electron-/photo-induced C60 polymerization finally results in formation of one-dimensional (1D) metallic peanut-shaped and 2D dumbbell-shaped semiconducting C60 polymers, respectively. This enables us to control the physicochemical properties of C60 films using electron-/photo-lithography techniques. In this review, we focused on the structures, fundamental properties, and potential applications of the low-dimensional C60 polymers and other nanocarbons such as C60 peapods, wavy-structured graphene, and penta-nanotubes with topological defects. We hope this review will provide new insights for producing new novel nanocarbon materials and inspire broad readers to cultivate new further research in carbon materials.

The development of new targets has become a top priority in pesticide research and development due to the problems of limited targets and drug resistance in agrochemicals. Chitin is a major component of insect epidermis and fungal cell wall, and has important biological functions. Chitin deacetylase (CDA) can deacetylate chitin to chitosan, which not only affects the formation of insect body wall and fungal cell wall, but also regulates the growth and development of insects or determines the pathogenicity of fungi. More and more studies have shown that CDA is expected to be a candidate target for the development of new pesticides. Therefore, the research progress of CDA as a potential target for crop protection, especially the biochemical functions, crystal structures, enzymesubstrate binding modes, and reported inhibitors of CDA from different sources in recent years were summarized in this review. The aim is to provide guidance for the screening of inhibitors targeting CDA and the development of novel pesticides. [ABSTRACT FROM AUTHOR]

Microporous organic polymers (MOPs) are a new type of porous materials, which have advantages of synthetic diversity, chemical and physical stability, microporous size controllability, etc. MOPs indicate broad applications in various fields such as heterogeneous catalysis, gas adsorption, separation, and storage. In recent years, MOPs have attracted an enormous attention in greenhouse gas capture due to their great potential in physisorptive gas storage. Carbazole and its derivatives have been studied extensively as Metal-Organic Polyhedra (MOPs) building blocks due to their unique structural features and versatile functionalization possibilities. This paper systematically reviews the synthesis, characterization and application of carbazole-based polymers, and relationship of structures and properties of these polymers. The application of the polymers in carbon dioxide (CO2) capture field is analysed taking advantage of their adjustable microporous structure and electron rich properties. This review also provides novel insights regarding functional polymer materials that have high ability of greenhouse gas capture and absorbing selectivity will be obtained by reasonable molecular design and efficient synthesis.

The valorization of lignin into biopolymers and other high-value products development is the most promising technology for sustainable development. This technology has gain importance for the development of kind of different biopolymers such as epoxies, polyesters, polyurethanes, phenol resins, polyhydroxyalkanoates, poly(lactic acids), and other useful biopolymers. However, lignin recalcitrance remains a potential problem for efficient lignin valorization, and therefore, several efforts have been made to develop high-efficiency bioprocesses for the synthesis of target polymer types, and other useful bioproducts. A comprehensive insight into lignin structure and properties will aid to understand the catalytic and metabolic deconstructive pathways for the efficient valorization of lignin. Due to the presence of multifunctional properties of lignin for the development of kinds of different biobased polymers, the review aims to highlight the biosynthesis and structure, potentialities of lignin and lignin-derivatives on polymers development, and future trends with outlook in lignin valorization have been systematically summarized. [ABSTRACT FROM AUTHOR]

This comprehensive study assesses the current state of the hydrogen energy system and investigates its potential to transform the global energy landscape while addressing important concerns about climate change. While hydrogen energy has numerous advantages, including sustainability and cleanliness, it faces substantial challenges in the areas of storage, manufacturing, distribution, infrastructure, safety, and cost. Scholars, lawmakers, business leaders, and the general public must all work together to address these complex issues. The research emphasizes the significance of breakthrough technology and astute government policies for the successful development and widespread deployment of hydrogen energy systems. It highlights that this revolutionary effort cannot be performed in solitude. Public education and enhanced awareness appear to be significant factors in promoting greater acceptance and use of hydrogen energy. Furthermore, the study identifies critical future research objectives. It underlines the importance of enhancing the efficiency, sustainability, safety, and economic feasibility of hydrogen energy systems. The development of new storage systems, superior infrastructure designs, and seamless integration technologies is vital to achieving the full potential of hydrogen energy. Finally, the research presented here gives a critical assessment of the hydrogen energy situation and outlines a roadmap toward a more sustainable and resilient future. The review's conclusions are significant for policymakers, academics, and stakeholders because they provide critical insights into the opportunities and problems associated with realizing the full potential of hydrogen energy. • Critical review of hydrogen for global energy needs and climate change is presented. • Potential applications and characteristics of hydrogen energy are scrutinized. • New technology and regulations are critical to developing hydrogen energy systems. • Acceptance and increased use of hydrogen energy are driven by increased awareness. • Future studies on hydrogen should include sustainability, safety, and feasibility. [ABSTRACT FROM AUTHOR]

Internet of Things (IoT) is the amalgamation of hardware, like sensors and trackers, which monitor several parameters of the environment or physical objects, and software that processes all the data gathered by hardware. Globally, the IoT market is anticipated to reach 53.8 billion USD by 2025. This enhancing demand is due to its innate ability to automate, which drives several industries to adopt IoT. In addition, minimum memory cost, processing, and storage with an increase in Big Data (BD), cloud, and conjunction of industrial networks and the internet are the added factors for the increase in IoT development. Due to this significance, IoT has applications in numerous areas like medical management, farming, wearable technology, smart energy meters, smart cities, etc. The applications are not limited to the examples mentioned above. Considering this, existing studies have considered different applications and attempted to execute them. As different applications have been focused on by these studies, the present review intends to provide a compilation of potential applications of IoT as considered by conventional research between 2018 and 2022. The study also intends to explore the advantages and disadvantages of different IoT applications (deliberated by conventional studies) through tabular analysis. Further, this review emphasizes IoT’s major key challenges and countermeasures to resolve its security issues. Finally, the study affords recommendations that will assist all IoT experts in bringing IoT products with enhanced security into the market. [ABSTRACT FROM AUTHOR]

Microporous organic polymers (MOPs) are a new type of porous materials, which have advantages of synthetic diversity, chemical and physical stability, microporous size controllability, etc. MOPs indicate broad applications in various fields such as heterogeneous catalysis, gas adsorption, separation, and storage. In recent years, MOPs have attracted an enormous attention in greenhouse gas capture due to their great potential in physisorptive gas storage. Carbazole and its derivatives have been studied extensively as Metal-Organic Polyhedra (MOPs) building blocks due to their unique structural features and versatile functionalization possibilities. This paper systematically reviews the synthesis, characterization and application of carbazole-based polymers, and relationship of structures and properties of these polymers. The application of the polymers in carbon dioxide (CO2) capture field is analysed taking advantage of their adjustable microporous structure and electron rich properties. This review also provides novel insights regarding functional polymer materials that have high ability of greenhouse gas capture and absorbing selectivity will be obtained by reasonable molecular design and efficient synthesis. [ABSTRACT FROM AUTHOR]

New chatbot models, built on the transformer architecture and trained on large amounts of data, have the potential to transform healthcare, including gastroenterology. In this paper, we synthesized current literature reports on the roles of chatbots, and evaluated their potential applications in various areas such as clinical diagnosis and treatment plans, patient triage, scientific research, and academic writing. We believe that chatbots can improve efficiency and patient outcomes in these fields. However, it is important to acknowledge some challenges that need to be addressed, such as privacy concerns and emotional considerations. Overall, chatbots are expected to have a significant influence on gastroenterology and require more research to comprehensively examine their capabilities.

Green synthesis is a simple, eco-friendly, and emerging approach to synthesizing nanoparticles and is currently attracting the scientific community worldwide. The objective of the present study was to synthesize green titanium dioxide NPs and evaluate their performance for the photocatalytic treatment of textile wastewater after the secondary treatment process. TiO2 NPs were synthesized using leaf extracts of asausage tree (Kigelia Africana) in asingle step. The green synthesized TiO2 NPs were characterized by Scanning Electron Microscopy (SEM), Energy Dispersive X-ray spectroscopy (EDX), X-Ray Diffraction (XRD), Fourier-Transform Infrared spectroscopy (FT-IR), Diffuse Light Scattering spectroscopy (DLS), Transmission Electron Microscopy (TEM). The findings validated the synthesis of the spherical-shaped TiO2 NPs and their anatase phase. The green-produced TiO2 NPs were used for the treatment of textile effluent. During the photocatalytic treatment of aself-designed dye solution, 99.59% removal of Toluidine blue(TB) dye was achieved within 60 minupon the treatment of green synthesized TiO2 NPs studied by a UV–Visible spectrophotometer. Therefore, the green TiO2NPs that were developed have been examined for the treatment of wastewater, and the catalyst has reusability make it more efficient and affordable, and it might be used to remove organic dyes from textile industries

Over the past few decades, nearly 300 known cyanotoxins and more than 2000 cyanobacterial secondary metabolites have been reported from the environment. Traditional studies have focused on the toxic cyanotoxins produced by harmful cyanobacteria, which pose a risk to both human beings and wildlife, causing acute and chronic poisoning, resulting in diarrhea, nerve paralysis, and proliferation of cancer cells. Actually, the biotechnological potential of cyanotoxins is underestimated, as increasing studies have demonstrated their roles as valuable products, including allelopathic agents, insecticides and biomedicines. To promote a comprehensive understanding of cyanotoxins, a critical review is in demand. This review aims to discuss the classifications; biosynthetic pathways, especially heterogenous production; and potential applications of cyanotoxins. In detail, we first discuss the representative cyanotoxins and their toxic effects, followed by an exploration of three representative biosynthetic pathways (non-ribosomal peptide synthetases, polyketide synthetases, and their combinations). In particular, advances toward the heterologous biosynthesis of cyanotoxins in vitro and in vivo are summarized and compared. Finally, we indicate the potential applications and solutions to bottlenecks for cyanotoxins. We believe that this review will promote a comprehensive understanding, synthetic biology studies, and potential applications of cyanotoxins in the future. [ABSTRACT FROM AUTHOR]

Marine algae are valuable sources of health-promoting molecules that have been consumed by Asians for decades. Among aquatic flora, marine algae stand out in terms of high content of marine algae polysaccharides (MAP) such as carrageenan, alginate, fucoidan, laminaran, agarose, rhamnan, and ulvan. When hydrolyzed, MAP generate marine algae oligosaccharides (MAO), which have attracted interest in recent years due to their superior solubility compared with MAP. Besides, MAO have been demonstrated numerous biological activities including antioxidant, antidiabetic, anti-inflammatory, antimicrobial, and prebiotic activities. Thus, this review summarizes the main chemical classes of MAO, their sources, and the main processes used for their production (i.e., physical, chemical, and biological methods), coupled with a discussion of the advantages and disadvantages of these methods. Highlights of the biological activities of MAO and their potential applications in food, nutraceutical, and pharmaceuticals would also be discussed and summarized.

Breakthroughs in materials science are the driving force behind many of today's industrial advancements in our fast-changing high-tech world. Composite materials have proven valuable in numerous sectors, including automotive, aerospace, aeronautics, naval, and sports, due to their exceptional mechanical properties and lightweight nature. However, environmental concerns have led to a decrease in the use of fossil fuel-derived materials. Additionally, efforts to reduce greenhouse gas emissions and improve fuel efficiency require lightweight materials with a lower carbon footprint, highlighting the importance of natural fiber composites. Natural fiber composites are made from renewable resources, comprising reinforcements made of natural fibers such as jute, flax, ramie, hemp, cotton, sisal, and kenaf, and a matrix, preferably derived from biomass, which may or may not be biodegradable. However, plant fibers have certain drawbacks when combined with polymers. Due to the presence of hydroxyl groups in lignocellulose, plant fibers are hydrophilic, making them incompatible with hydrophobic thermoplastics and prone to moisture damage. These limitations pose challenges for using plant fibers as polymer reinforcement. To improve adhesion between fibers and the polymer matrix and reduce moisture absorption, surface modifications are typically required. Various methods, such as alkaline, silane, or other chemical treatments, have been developed to enhance fiber-matrix compatibility and improve composite quality. Although natural fiber composites are still in development and their applications are limited, they hold great promise as a sustainable alternative to conventional materials.

Coffee is among the most widely consumed beverages worldwide, leading to the annual generation of substantial quantities of spent coffee grounds (SCGs). This study explored the influence of fabrication methods on the properties and potential applications of the resulting biocarbon materials. Dry methods (torrefaction at 270 °C and slow pyrolysis at 500 °C) and wet methods (hydrothermal carbonization HTC at 210 °C and hydrothermal liquefaction HTL at 270 °C) were employed to fabricate SCG-based biochar and hydrochar, respectively. The carbonization degree followed the order of slow pyrolysis > HTL > HTC ≈ torrefaction, yielding significant differences in energy properties, elemental composition, morphology, and surface functionality. Slow pyrolysis biochar was suitable for energy applications due to a similar fuel ratio as and higher heating value than semianthracite coal. For agricultural applications, SCG biochar produced through dry methods could be utilized to mitigate acidic soil conditions, whereas HTC hydrochar, with its elevated surface area and porosity, could enhance soil microbiological diversity and water-holding capacity, as well as benefit environmental applications such as wastewater remediation. In summary, the findings of this study are anticipated to inform decision-making processes concerning sustainable waste management of SCGs and the exploration of carbon-based materials applications across diverse sectors. [ABSTRACT FROM AUTHOR]

Abstract Collagen is a biofunctional protein that has been widely used in many fields, including but not limited to biomedical, cosmetics and skin care, food, and novel materials. Recombinant collagen has great potential as an alternative to collagen extracted from animals because it avoids the immune response, and the yield and properties are stable. However, challenges remain in the industrial application of recombinant collagen, including improving the expression yield, reducing the cost of purification for industry and expanding applications. In this study, a cloning and recombination method was used to heterologously express the recombinant human-like collagen (RHLC) in Pichia pastoris GS115 using the pPIC9k expression vector. The RHLC expression titre was 2.33 g/L via a 5-L fermenter, and the purification was completed within 48 h and was 98% pure. The characteristics of RHLC were investigated. Furthermore, potential applications for RHLC were explored, such as basal collagen sponge preparation, forming films with chitosan and production of collagen hydrolysed peptides. RHLC has various potential applications due to its triple helical structure, thermostability, good biocompatibility and film-forming ability. Graphical Abstract

With pleasant organoleptic properties, aging characteristics and promising medicinal potential, white tea (WT) has been consumed worldwide for a long history, and revived among consumers and researchers in recent decades. Nevertheless, present researches focused on WT are majorly about chemical compositions and bioactivities, which are remaining at infancy. Besides, there is lacking a systematic generalization of the underlying correlations among manufacturing process, characteristic chemicals, sensory traits and pharmacological benefits; as well as explorations on quality amelioration and potential orientations are still insufficient. Simultaneously, the typical aging process of WT also lacks profound recognition. In this review, the latest research progresses of WT were summarized, mainly emphasizing on the investigations within past five years. We systematically review the manufacturing process, bioactive substances, aging characteristics and health benefits of WT, thoroughly discuss the present challenges and deficiency in the researches, and put forward possible orientations and perspectives. Through manufacturing process involving only the two major steps (withering and drying), the active substances in WT such as polyphenols and amino acids, are retained in large quantities, contributing to its pleasant organoleptic quality and pharmacological benefits. Additionally, WT also has the peculiarity of quality transformation during aging, which brings about altered flavor and pharmacological benefits. This is a full-scale and cutting-edge review about WT, for the first time, the saying about WT that "One year's tea, three years' medicine, and seven years' treasure" is systematically reviewed and evaluated from a scientific point of view, which will enlighten some innovate strategies for further progress of WT industry. [Display omitted] • Manufacturing process of white tea is meticulously elucidated. • Chemical compositions and bioactivities are thoroughly presented. • Quality transformation in aging process are comprehensively analyzed. • Challenges and perspectives of WT are put forward. [ABSTRACT FROM AUTHOR]

Allotropes of carbon are responsible for discovering the three significant carbon-based compounds, fullerene, carbon nanotubes, and graphene. Over the last few decades, groundbreaking graphene with the finest two-dimensional atomic structure has emerged as the driving force behind new research and development because of its remarkable mechanical, electrical, thermal, and optical functionalities with high surface area. Synthesis of graphene oxide (GO) and reduced graphene oxide (rGO) has resulted in numerous applications that previously had not been possible, incorporating sensing and adsorbent properties. Our study covers the most prevalent synthetic methods for making these graphene derivatives and how these methods impact the material's main features. In particular, it emphasizes the application to water purification, CO2 capture, biomedical, potential energy storage, and conversion applications. Finally, we look at the future of sustainable utilization, its applications, and the challenges which must be solved for efficient application of graphene at large scales. Graphene-based derivative implementations, obstacles, and prospects for further research and development are also examined in this review paper. [ABSTRACT FROM AUTHOR]

This study aims to develop a new refreshing feeling, ecological, and antimicrobial fabrics for medicinal applications. The geranium essential oils (GEO) are incorporated into polyester and cotton fabrics by different methods, such as ultrasound, diffusion, and padding. The effect of solvent, nature of fibers, and treatment processes were evaluated via the thermal properties, the color strength, the odor intensity, the wash fastness, and the antibacterial activities of the fabrics. It was found that the ultrasound method was the most efficient process for incorporation of GEO. Ultrasound produced a great effect on the color strength of the treated fabrics, suggesting the absorption of geranium oil in fiber surface. The color strength (K/S) increased from 0.22 for the original fabric to 0.91 for the modified counterpart. In addition, the treated fibers showed appreciable antibacterial capacity against Gram-positive (Staphylococcus epidermidis) and Gram-negative (Escherichia coli) bacteria strains. Moreover, the ultrasound process can effectively guarantee the stability of geranium oil in fabrics without decreasing the significant odor intensity and antibacterial character. Based on the interesting properties like ecofriendliness, reusability, antibacterial, and a refreshing feeling, it was suggested that textile impregnated with geranium essential oil might be used as a potential material in cosmetic applications. [ABSTRACT FROM AUTHOR]

In nature, aquatic organisms have evolved various attachment systems, and their attachment ability has become a specific and mysterious survival skill for them. Therefore, it is significant to study and use their unique attachment surfaces and outstanding attachment characteristics for reference and develop new attachment equipment with excellent performance. Based on this, in this review, the unique non-smooth surface morphologies of their suction cups are classified and the key roles of these special surface morphologies in the attachment process are introduced in detail. The recent research on the attachment capacity of aquatic suction cups and other related attachment studies are described. Emphatically, the research progress of advanced bionic attachment equipment and technology in recent years, including attachment robots, flexible grasping manipulators, suction cup accessories, micro-suction cup patches, etc., is summarized. Finally, the existing problems and challenges in the field of biomimetic attachment are analyzed, and the focus and direction of biomimetic attachment research in the future are pointed out. [ABSTRACT FROM AUTHOR]

Retinoblastoma (RB), the most common malignant retinal tumor among children under 3 years old, is lethal if left untreated. Early diagnosis, together with timely and effective treatment, is important to improve retinoblastoma-related outcomes. Circular RNAs (circRNAs), a new class of non-coding RNAs with the capacity to regulate cellular activities, have great potential in retinoblastoma diagnosis and treatment. Recent studies have identified circular RNAs that regulate multiple cellular processes involved in retinoblastoma, including cell viability, proliferation, apoptosis, autophagy, migration, and invasion. Six circular RNAs (circ-FAM158A, circ-DHDDS, circ-E2F3, circ-TRHDE, circ-E2F5, and circ-RNF20) promote disease progression and metastasis in retinoblastoma and function as oncogenic factors. Other circular RNAs, such as circ-TET1, circ-SHPRH, circ-MKLN1, and circ-CUL2, play tumor suppressive roles in retinoblastoma. At present, the studies on the regulatory mechanism of circular RNAs in retinoblastoma are not very clear. The purpose of this review is to summarize recent studies on the functional roles and molecular mechanisms of circular RNAs in retinoblastoma and highlight novel strategies for retinoblastoma diagnosis, prognosis, and treatment. [ABSTRACT FROM AUTHOR]

G-quadruplexes (G4s) are non-canonical nucleic acid structures formed by guanine (G)-rich sequences, which are ubiquitously found in the human genome and transcriptome. Targeting G4s by specific ligands provides a powerful tool to monitor and regulate G4s-associated biological processes. RHAU peptides, derived from the G4-binding motif of "RNA Helicase associated with AU-rich element" (RHAU), have emerged as extraordinary ligands for specific recognition of parallel G4s. This review highlights the significances of recent studies investigating potential applications of the engineered RHAU peptides incorporated to different functional moieties. [ABSTRACT FROM AUTHOR]

The development of space robots is vital to broadening human cognitive boundaries. Space robots have been deployed in space science experiments, extravehicular operations, and deep space exploration. The application of space robots undoubtedly reduces the risk and cost of space activities. Traditional space robots primarily utilize rigid structures, resulting in limited degrees of freedom, which restricts their operational capabilities. In contrast, soft robots with greater flexibility and robustness may be used for future space exploration. Soft robots applied in space environments must overcome significant challenges associated with ultrahigh vacuum, microgravity, extreme temperatures, and high‐energy radiation. Herein, a comprehensive analysis of the key advantages of soft robots is presented based on the special requirements of the space environments for soft robots. Furthermore, brief insights into how soft robots must be changed in terms of their design, modeling, fabrication, sensing, and control to adapt to space environments are discussed. Specifically, soft robot scenarios with potential space application value are introduced. Finally, opinions regarding the potential directions of soft space robots are provided. [ABSTRACT FROM AUTHOR]

There is a lower requirement for river sand in construction because of a number of logistical and environmental problems. In response to these issues, alternative materials are being increasingly recognized by the construction field progressively M. Sand, derived from the mining and processing of rocks that is a low-particle-size substitute to natural sand which demonstrates potential. Amongst its numerous applications are surface polishing, prefabricated cement components, hollow block development, and lightweight component production. Practitioners and researchers both have been giving special attention on the usage of M. sand in the last few years. This has led to further study into its suitability for replacing river sand in concrete production. The formulation of concrete blends using M. Sand has been made possible through various mix designs developed according to relevant design codes such as IS codes. An assessment of the mechanical properties and structural performance -of concrete containing M. Sand has been conducted using cubes, cylinders, and beams compared to traditional natural sand concrete. As a result of these tests, the compressive, flexural, and tensile strength properties of M. Sand and M. Sand can be compared, suggesting M. Sand has similar properties. Concrete construction applications can utilize sand as an environmentally sustainable and viable alternative to natural-river sand, thereby addressing sustainability concerns and resource scarcity concerns.

In recent years, the field of metal-halide perovskite emitters has rapidly emerged as a new community in solid-state lighting. Their exceptional optoelectronic properties have contributed to the rapid rise in external quantum efficiencies (EQEs) in perovskite light-emitting diodes (PeLEDs) from

The development of space robots is vital to broadening human cognitive boundaries. Space robots have been deployed in space science experiments, extravehicular operations, and deep space exploration. The application of space robots undoubtedly reduces the risk and cost of space activities. Traditional space robots primarily utilize rigid structures, resulting in limited degrees of freedom, which restricts their operational capabilities. In contrast, soft robots with greater flexibility and robustness may be used for future space exploration. Soft robots applied in space environments must overcome significant challenges associated with ultrahigh vacuum, microgravity, extreme temperatures, and high‐energy radiation. Herein, a comprehensive analysis of the key advantages of soft robots is presented based on the special requirements of the space environments for soft robots. Furthermore, brief insights into how soft robots must be changed in terms of their design, modeling, fabrication, sensing, and control to adapt to space environments are discussed. Specifically, soft robot scenarios with potential space application value are introduced. Finally, opinions regarding the potential directions of soft space robots are provided.

In the upcoming years, the world will face societal challenges arising, in particular, from the impact of climate change and the inefficient use of natural resources, in addition to an exponential growth of the world population, which according to the United Nations (UN) estimations will be 9.8 billion in 2050. This increasing trend requires optimized management of natural resources with the use of value-added waste and a significant reduction in food loss and food waste. Moreover, the recent pandemic situation, COVID-19, has contributed indisputably. Along with the agri-food supply chain, several amounts of waste or by-products are generated. In most cases, these biomass wastes cause serious environmental concerns and high costs to enterprises. The valorisation of the agri-food loss and food industry wastes emerged as a useful strategy to produce certain value-added compounds with several potential applications, namely in the food, health, pharmaceutical, cosmetic, and environmental fields. Therefore, in this review, some of the crucial sustainable challenges with impacts on the valorisation of agri-food loss/wastes and by-products are discussed and identified, in addition to several opportunities, trends and innovations. Potential applications and usages of the most important compounds found in food loss/waste will be highlighted, with a focus on the food industry, pharmaceutical industry, and the environment. [ABSTRACT FROM AUTHOR]

Houttuynia cordata Thunb, also known as "Chinese medicine antibiotic", is a medicine food homology plant. It has functions of clearing heat, eliminating toxins, in folk medicine. The extraction purification and bioactivity of Houttuynia cordata polysaccharides (HCPs) have been of wide interest to researchers in recent years studies. Studies have confirmed that HCPs exhibit various biofunctionalities, such as anti-inflammatory, antiviral, antibacterial, antioxidant, immunomodulatory, regulation of gut microbiota, and gut-lung axis, as well as anti-radiation, and anti-cancer properties. Therefore, a comprehensive systematic review is needed to summarize the recent advances of HCPs and facilitate a better understanding of their biofunctionalities. This paper reviews the research progress of HCPs in extraction and purification methods, chemical structures, biological activities, possible mechanisms of action, and potential application prospects, which can provide some valuable insights and updated information for their further development and application of HCPs in the fields of therapeutic agents, functional foods, cosmetics, animal feeds. [Display omitted] • Introduces the natural polysaccharides in medicine food homology Houttuynia cordata (HCPs). • Preparation methods and structural features of HCPs were summarized. • Pharmacological properties, and potential application of HCPs were outlined. • Future perspectives and challenges of HCPs were proposed. [ABSTRACT FROM AUTHOR]

Prepared dishes are becoming increasingly popular due to their convenience and nutritional value. However, warmed-over flavor (WOF), which occurs during production and reheating, negatively affects consumer acceptance. To enhance market consumption, it's crucial to control WOF by explaining its composition and formation process. This paper is written along the lines of WOF formation to regulation in prepared dishes. The main WOF forming substances and formation mechanism were elucidated. Direct control strategies (sous vide technology, reheating methods), potential control strategies (cold plasma, antioxidants, novel packaging methods, low-temperature storage) and their suitability of WOF were highlighted. Finally, future trends for WOF in prepared dishes were also proposed. The volatile compounds, including aldehydes, ketones, and alcohol are the main flavor compounds of WOF in prepared dishes. Moreover, WOF mainly arises from lipid oxidation and protein degradation during heat treatment and storage. Furthermore, six innovative control strategies aimed at effectively regulating the generation of WOF are summarized according to their effects. Future research should focus on exploring the interactions between formation mechanisms, investigating the effect of microwave-combined other reheating technologies and synergistic effects of natural antioxidants on WOF, developing visualized smart packaging for increasing the consumption of prepared dishes. [Display omitted] • Warmed-over flavor is a crucial factor in consumer acceptance of prepared dishes. • The composition of the warmed-over flavor and its adverse effects are reviewed. • Warmed-over flavor mainly results from lipid oxidation and protein degradation. • Six control strategies are promising for regulating Warmed-over flavor. • Future exploration should focus on non-thermal processing and novel antioxidants. [ABSTRACT FROM AUTHOR]

Porphyra yezoensis , an important medicinal seaweed extensively cultivated and consumed in China, Japan, and South Korea, is traditionally considered a precious healthy food and food additive. Published studies showed that the polysaccharides are major bioactive macromolecules from P. yezoensis with great potential for the development of nutraceuticals and functional foods. As an important component of P. yezoensis , P. yezoensis polysaccharide (PYP) is mainly extracted by hot water extraction, ultrasonic-assisted extraction, and microwave-assisted extraction methods. Subsequently obtained by decolorization, deproteinization, removal of other small molecules, and separation on various chromatographic columns. The main structural components of PYP were (1 → 3)-linked β-D-galactose and (1 → 4)-linked 3,6-anhydro-α-L-galactose. Accumulating evidence has revealed that PYP has diverse biological activities, such as antioxidant, suppressing kidney stones, immunomodulatory, etc. This review systematically summarizes the recent preparation progress, chemical structures, bioactivities, and the underlying mechanisms of PYP. Information from this review provides insights into the further development of PYP as therapeutic agents and functional foods. Although there have been extensive studies on PYP, there are gaps in establishing quality standard, toxicological research, clinical application and other aspects. To enhance the utility of P. yezoensis , it is necessary to strengthen the research on these aspects. [Display omitted] [ABSTRACT FROM AUTHOR]

Over the past few decades, nearly 300 known cyanotoxins and more than 2000 cyanobacterial secondary metabolites have been reported from the environment. Traditional studies have focused on the toxic cyanotoxins produced by harmful cyanobacteria, which pose a risk to both human beings and wildlife, causing acute and chronic poisoning, resulting in diarrhea, nerve paralysis, and proliferation of cancer cells. Actually, the biotechnological potential of cyanotoxins is underestimated, as increasing studies have demonstrated their roles as valuable products, including allelopathic agents, insecticides and biomedicines. To promote a comprehensive understanding of cyanotoxins, a critical review is in demand. This review aims to discuss the classifications; biosynthetic pathways, especially heterogenous production; and potential applications of cyanotoxins. In detail, we first discuss the representative cyanotoxins and their toxic effects, followed by an exploration of three representative biosynthetic pathways (non-ribosomal peptide synthetases, polyketide synthetases, and their combinations). In particular, advances toward the heterologous biosynthesis of cyanotoxins in vitro and in vivo are summarized and compared. Finally, we indicate the potential applications and solutions to bottlenecks for cyanotoxins. We believe that this review will promote a comprehensive understanding, synthetic biology studies, and potential applications of cyanotoxins in the future.

Abstract Cold-adapted organisms, such as fishes, insects, plants and bacteria produce a group of proteins known as antifreeze proteins (AFPs). The specific functions of AFPs, including thermal hysteresis (TH), ice recrystallization inhibition (IRI), dynamic ice shaping (DIS) and interaction with membranes, attracted significant interest for their incorporation into commercial products. AFPs represent their effects by lowering the water freezing point as well as preventing the growth of ice crystals and recrystallization during frozen storage. The potential of AFPs to modify ice growth results in ice crystal stabilizing over a defined temperature range and inhibiting ice recrystallization, which could minimize drip loss during thawing, improve the quality and increase the shelf-life of frozen products. Most cryopreservation studies using marine-derived AFPs have shown that the addition of AFPs can increase post-thaw viability. Nevertheless, the reduced availability of bulk proteins and the need of biotechnological techniques for industrial production, limit the possible usage in foods. Despite all these drawbacks, relatively small concentrations are enough to show activity, which suggests AFPs as potential food additives in the future. The present work aims to review the results of numerous investigations on marine-derived AFPs and discuss their structure, function, physicochemical properties, purification and potential applications. Graphical Abstract

Collagen is a biofunctional protein that has been widely used in many fields, including but not limited to biomedical, cosmetics and skin care, food, and novel materials. Recombinant collagen has great potential as an alternative to collagen extracted from animals because it avoids the immune response, and the yield and properties are stable. However, challenges remain in the industrial application of recombinant collagen, including improving the expression yield, reducing the cost of purification for industry and expanding applications. In this study, a cloning and recombination method was used to heterologously express the recombinant human-like collagen (RHLC) in Pichia pastoris GS115 using the pPIC9k expression vector. The RHLC expression titre was 2.33 g/L via a 5-L fermenter, and the purification was completed within 48 h and was 98% pure. The characteristics of RHLC were investigated. Furthermore, potential applications for RHLC were explored, such as basal collagen sponge preparation, forming films with chitosan and production of collagen hydrolysed peptides. RHLC has various potential applications due to its triple helical structure, thermostability, good biocompatibility and film-forming ability. [ABSTRACT FROM AUTHOR]

Glioblastoma multiforme (GBM) is the most malignant and common form of brain cancer in adults. The molecular mechanisms underlying GBM progression and resistance are complex and poorly understood. Circular RNAs (circRNAs) are a new class of non-coding RNAsformed by covalently closed loopstructures with no free ends. Their circular structure makes them more stable than linear RNA and resistant to exonuclease degradation. In recent years, they have received significant attention due to their diverse functions in gene regulation and their association with various diseases, including cancer. Therefore, understanding the functions and applications of circRNAs is critical to developing targeted therapeutic interventions and advancing the field of glioblastoma cancer research. In this review, we summarized the main functions of circRNAs and their potential applications in the diagnosis, prognosis and targeted therapy of GBM., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)