Search

Your search keyword '"Post Uiterweer, E.D."' showing total 13 results
Start Over Author "Post Uiterweer, E.D."
13 results on '"Post Uiterweer, E.D."'

5. Circulating pregnancy hormone relaxin as a first trimester biomarker for preeclampsia

Author

Post Uiterweer, E.D. (Emiel D.), Koster, M.P.H. (Maria), Jeyabalan, A. (Arun), Kuc, S. (Sylwia), Siljee, J.E. (Jacqueline), Stewart, D.R. (Dennis R.), Conrad, K.P. (Kirk P.), Franx, A. (Arie), Post Uiterweer, E.D. (Emiel D.), Koster, M.P.H. (Maria), Jeyabalan, A. (Arun), Kuc, S. (Sylwia), Siljee, J.E. (Jacqueline), Stewart, D.R. (Dennis R.), Conrad, K.P. (Kirk P.), and Franx, A. (Arie)

Abstract

Objective: Preeclampsia, a multi-system hypertensive disorder, is associated with perturbations in the maternal cardiovascular system during early pregnancy. The corpus luteal hormone relaxin, a potent vasodilator, may contribute to physiological circulatory changes especially in early gestation when circulating levels are highest. This study investigated whether first trimester circulating relaxin may be a suitable biomarker for the early prediction of preeclampsia. Methods: Relaxin was initially measured in first-trimester samples of women who developed late-onset preeclamptic (LO-PE; delivery ≥ 34 weeks; n = 33) and uncomplicated pregnancies (n = 25) in Pittsburgh, USA. Subsequently, to expand the group numbers, relaxin was measured in women who developed LO-PE (n = 95), early-onset preeclamptic (EO-PE; delivery < 34 weeks; n = 57), and uncomplicated pregnancies (n = 469) in Utrecht, the Netherlands. Results: In the Pittsburgh subjects, low relaxin levels (lowest centile:

Published
2020
Full Text
View/download PDF

6. Uterine immunovascular adaptations in early pregnancy

Author

Post Uiterweer, E.D., Franx, A., Heijnen, C.J., Eijkelkamp, N., Peeters, L.L.H., and University Utrecht

Subjects
preeclampsia, RXFP1, decidualization, placentation, pregnancy, NK cells, relaxin, macrophages
Abstract

The overall purpose of the projects described in this thesis was to study the regulation of uterine changes that are essential for the developmental processes of placentation. We explored the role of relaxin along with its receptor RXFP1 in the maternal adaptation to pregnancy. Moreover, we identified a novel type I interferon pathway that regulates the uterine NK (uNK) cell transcriptome and function in human pregnancy. Finally, we characterized the progressive transcriptional changes of the endometrium over the secretory phase of the menstrual cycle and first weeks of pregnancy. To this end, we defined which genes are involved in endometrial maturation and determined, whether the transcriptional regulation of these decidualization-associated genes is disturbed early in pregnancies later on complicated by preeclampsia.

Published
2015

Catalog

Books, media, physical & digital resources
See catalog results