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After 15 yr, in late 2018, the magnetar XTE J1810-197 underwent a second recorded X-ray outburst event and reactivated as a radio pulsar. We initiated an X-ray monitoring campaign to follow the timing and spectral evolution of the magnetar as its flux decays using Swift, XMM-Newton, NuSTAR, and NICER observations. During the year-long campaign, the magnetar reproduced similar behaviour to that found for the first outburst, with a factor of 2 change in its spin-down rate from ∼7.2 × 10-12 to ∼1.5 × 10-11 s s-1 after two months. Unique to this outburst, we confirm the peculiar energy-dependent phase shift of the pulse profile. Following the initial outburst, the spectrum of XTE J1810-197 is well modelled by multiple blackbody components corresponding to a pair of non-concentric, hot thermal caps surrounded by a cooler one, superposed to the colder star surface. We model the energy-dependent pulse profile to constrain the viewing and surface emission geometry and find that the overall geometry of XTE J1810-197 has likely evolved relative to that found for the 2003 event.

The detection of a short hard X-ray burst and an associated bright soft X-ray source by the Swift satellite in 2020 October heralded a new magnetar in outburst, SGR J1830-0645. Pulsations at a period of ∼10.4 s were detected in prompt follow-up X-ray observations. We present here the analysis of the Swift/Burst Alert Telescope burst, of XMM-Newton and the Nuclear Spectroscopic Telescope Array observations performed at the outburst peak, and of a Swift/X-ray Telescope monitoring campaign over the subsequent month. The burst was single-peaked, lasted ∼6 ms, and released a fluence of ≈ 5 × 10-9 erg cm-2 (15-50 keV). The spectrum of the X-ray source at the outburst peak was well described by an absorbed double-blackbody model plus a power-law component detectable up to ∼25 keV. The unabsorbed X-ray flux decreased from ∼5 × 10-11 to ∼2.5 × 10-11 erg cm-2 s-1 one month later (0.3-10 keV). Based on our timing analysis, we estimate a dipolar magnetic field ≈5.5 × 1014 G at pole, a spin-down luminosity ≈2.4 × 1032 erg s-1, and a characteristic age ≈24 kyr. The spin modulation pattern appears highly pulsed in the soft X-ray band, and becomes smoother at higher energies. Several short X-ray bursts were detected during our campaign. No evidence for periodic or single-pulse emission was found at radio frequencies in observations performed with the Sardinia Radio Telescope and Parkes. According to magneto-thermal evolutionary models, the real age of SGR J1830-0645 is close to the characteristic age, and the dipolar magnetic field at birth was slightly larger, ∼1015 G.

Background Scientific literature on cystic echinococcosis (CE) reporting data on risk factors is limited and to the best of our knowledge, no global evaluation of human CE risk factors has to date been performed. This systematic review (SR) summarizes available data on statistically relevant potential risk factors (PRFs) associated with human CE., Methodology/Principal Findings Database searches identified 1,367 papers, of which thirty-seven were eligible for inclusion. Of these, eight and twenty-nine were case-control and cross-sectional studies, respectively. Among the eligible papers, twenty-one were included in the meta-analyses. Pooled odds ratio (OR) were used as a measure of effect and separately analysed for the two study designs. PRFs derived from case-control studies that were significantly associated with higher odds of outcome were ªdog free to roamº (OR 5.23; 95% CI 2.45±11.14), ªfeeding dogs with visceraº (OR 4.69; 95% CI 3.02±7.29), ªslaughter at homeº (OR 4.67; 95% CI 2.02±10.78) or at ªslaughterhousesº (OR 2.7; 95% CI 1.15±6.3), ªdog ownershipº (OR 3.54; 95% CI 1.27±9.85), ªliving in rural areasº (OR 1.83; 95% CI 1.16±2.9) and ªlow incomeº (OR 1.68; 95% CI 1.02±2.76). Statistically significant PRFs from cross-sectional studies with higher odds of outcome were ªage >16 yearsº (OR 6.08; 95% CI 4.05±9.13), ªliving in rural areasº (OR 2.26; 95% CI 1.41±3.61), ªbeing femaleº (OR 1.38; 95% CI 1.06± 1.8) and ªdog ownershipº (OR 1.37; 95% CI 1.01±1.86). Conclusions/Significance Living in endemic rural areas, in which free roaming dogs have access to offal and being a dog-owner, seem to be among the most significant PRFs for acquiring this parasiticinfection. Results of data analysed here may contribute to our understanding of the PRFs for CE and may potentially be useful in planning community interventions aimed at controlling CE in endemic areas., Conclusions/Significance Living in endemic rural areas, in which free roaming dogs have access to offal and being a dog-owner, seem to be among the most significant PRFs for acquiring this parasiticinfection. Results of data analysed here may contribute to our understanding of the PRFs for CE and may potentially be useful in planning community interventions aimed at controlling CE in endemic areas.

Background: This study aimed to provide a systematic review on the geographical distribution of Echinococcus multilocularis in definitive and intermediate hosts in the European Union (EU) and adjacent countries (AC). The relative importance of the different host species in the life-cycle of this parasite was highlighted and gaps in our knowledge regarding these hosts were identified. Methods: Six databases were searched for primary research studies published from 1900 to 2015. From a total of 2,805 identified scientific papers, 244 publications were used for meta-analyses. Results: Studies in 21 countries reported the presence of E. multilocularis in red foxes, with the following pooled prevalence (PP): low (≤ 1 %; Denmark, Slovenia and Sweden); medium (> 1 % to < 10 %; Austria, Belgium, Croatia, Hungary, Italy, the Netherlands, Romania and the Ukraine); and high (> 10 %; Czech Republic, Estonia, France, Germany, Latvia, Lithuania, Poland, Slovakia, Liechtenstein and Switzerland). Studies from Finland, Ireland, the United Kingdom and Norway reported the absence of E. multilocularis in red foxes. However, E. multilocularis was detected in Arctic foxes from the Arctic Archipelago of Svalbard in Norway. Conclusions: Raccoon dogs (PP 2.2 %), golden jackals (PP 4.7 %) and wolves (PP 1.4 %) showed a higher E. multilocularis PP than dogs (PP 0.3 %) and cats (PP 0.5 %). High E. multilocularis PP in raccoon dogs and golden jackals correlated with high PP in foxes. For intermediate hosts (IHs), muskrats (PP 4.2 %) and arvicolids (PP 6.0 %) showed similar E. multilocularis PP as sylvatic definitive hosts (DHs), excluding foxes. Nutrias (PP 1.0 %) and murids (PP 1.1 %) could play a role in the life-cycle of E. multilocularis in areas with medium to high PP in red foxes. In areas with low PP in foxes, no other DH was found infected with E. multilocularis. When fox E. multilocularis PP was >3 %, raccoon dogs and golden jackals could play a similar role as foxes. In areas with hig