835 results on '"Poso, Antti"'
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2. The molecular interaction pattern of lenvatinib enables inhibition of wild-type or kinase-mutated FGFR2-driven cholangiocarcinoma
3. Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease Mpro and Papain-like Protease PLpro of SARS-CoV‑2
4. 1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors
5. Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships
6. First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure
7. Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome
8. Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells
9. HDAC specificity and kinase off-targeting by purine-benzohydroxamate anti-hematological tumor agents
10. HilE represses the activity of the Salmonella virulence regulator HilD via a mechanism distinct from that of intestinal long-chain fatty acids
11. Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily
12. Effects of PCSK9 missense variants on molecular conformation and biological activity in transfected HEK293FT cells
13. Synthesis and evaluation of 1,2,3-dithiazole inhibitors of the nucleocapsid protein of feline immunodeficiency virus (FIV) as a model for HIV infection
14. Inhibitor induced conformational changes in SARS-COV-2 papain-like protease
15. Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like processes
16. Targeting Cyclophilin A in the Cardiac Microenvironment Preserves Heart Function and Structure in Failing Hearts.
17. Molecular Modeling of Protein Kinases: Current Status and Challenges
18. Virus structure and structure-based antivirals
19. Discovery of a synthetic small molecule targeting the central regulator of Salmonella pathogenicity
20. Filling the Blank Space: Branched 4-Nonylphenol Isomers Are Responsible for Robust Constitutive Androstane Receptor (CAR) Activation by Nonylphenol
21. Correction to “Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity”
22. Molecular characteristics supporting l-Type amino acid transporter 1 (LAT1)-mediated translocation
23. The autoinhibited state of MKK4: Phosphorylation, putative dimerization and R134W mutant studied by molecular dynamics simulations
24. Development of Selective Pyrido[2,3-d]pyrimidin-7(8H)-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors
25. Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity
26. Aminopyrimidine Derivatives as Multiflavivirus Antiviral Compounds Identified from a Consensus Virtual Screening Approach
27. Cyclophilin A is a ligand for RAGE in thrombo-inflammation
28. LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer
29. Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships
30. Development of Ligands for the Super Conserved Orphan G Protein-Coupled Receptor GPR27 with Improved Efficacy and Potency
31. Identification of structural features in chemicals associated with cancer drug response: A systematic data-driven analysis
32. Targeting extracellular and juxtamembrane FGFR2 mutations in chemotherapy-refractory cholangiocarcinoma
33. SARS‐CoV‐2–host proteome interactions for antiviral drug discovery
34. Pyridinylimidazoles as dual glycogen synthase kinase 3β/p38α mitogen-activated protein kinase inhibitors
35. Exploring the chemical space for freeze-drying excipients
36. Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs
37. Virtual Screening Assisted Search for Inhibitors of the Translocated Intimin Receptor of Enteropathogenic Escherichia Coli
38. Development of selective pyrido[2,3-d]pyrimidin-7(8H)-one-based Mammalian STE20-like (MST3/4) kinase inhibitors
39. Targeting Glial Cells by Organic Anion-Transporting Polypeptide 1C1 (OATP1C1)-Utilizing l-Thyroxine-Derived Prodrugs
40. HDAC specificity and kinase off-targeting by purine-benzohydroxamate anti-hematological tumor agents
41. Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells
42. Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors
43. Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors
44. Machine Learning-Boosted Docking Enables the Efficient Structure-Based Virtual Screening of Giga-Scale Enumerated Chemical Libraries
45. Molecular Modeling of Protein Kinases: Current Status and Challenges
46. Drug discovery on an unprecedented scale: Boosting virtual screening with machine learning allowed for a 10-fold time reduction in the processing of 1.56 billion drug-like molecules
47. 1,3-diphenylureido hydroxamate: a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors
48. Structure-based discovery of thiosemicarbazones as SARS-CoV-2 main protease inhibitors
49. Design, synthesis, and biological evaluation of 2,4-dihydropyrano[2,3-c]pyrazole derivatives as autotaxin inhibitors
50. Surface area, volume and shape descriptors as a novel tool for polymer lead design and discovery
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