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In this article an 80-year old female who was admitted to our hospital because of syncope. After effective therapy the decision about discharging of the patient was taken. This information was met with firm refusal of the patient's granddaughter. From this time the state of health of the elderly patient was getting worse after each granddaughter's visit. The consciousness disturbances from somnolence to coma appeared. The clinical symptoms increased in the afternoon and in the evening decreased late at night and in the morning. In some toxicological tests there was very high serum benzodiazepines level (160.7 ng/ml). The inspection of the doctor's permanent and temporary orders excluded the possibility of administering the benzodiazepines by the hospital's staff. After the honest talk with the granddaughter and reducing her contacts with the patient, the serum benzodiazepines started to decrease to the zero level and the consciousness disturbances disappeared.

The case report of a 20 year old woman with fulminant liver failure and hemolytic syndrome was described. Huge amounts of copper excreted in the urine (3555 mg/12 h without, and 5180 mg/12 h after d-penicillamine provocation, respectively) confirmed the diagnosis of fulminant Wilson's disease. Because the patient's general condition worsened rapidly (hemolysis, diathesis hemorrhagic, ascites, encephalopathy increased during 3 days of clinical observation) orthotopic liver transplantation was performed. After the transplantation, ischemic type biliary lesion (ITBL) II stage was diagnosed. The woman is still being treated with Prograf and Urso-Falk. The patient returned to her normal life, continues to work and was married. Two years after OLT she gave birth to a healthy boy. The liver function tests are normal with the exception of GGTP and FALK activities elevation. Copper and ceruloplasmin level, as well as copper excretion in the urine are within the normal values.