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1. Daily stress and coping strategies: Relationships with anxiety and resilience in preadolescents from Ciudad Juarez, Mexico

Author

Portillo-Reyes, Verónica, Capps, John W., Loya-Mèndez, Yolanda, Reyes-Leal, Gilberto, and Quiñones-Soto, Juan

Subjects
Coping (Psychology) -- Methods, Anxiety in children -- Research, Stress in children -- Research, Psychological research, Resilience (Personality trait) -- Research, Stress management -- Methods, Psychology and mental health
Abstract

Prior research demonstrates that stress and coping strategies have a significant influence on development and wellbeing, however few studies focus on the impact of daily stressors and coping strategies on anxiety and resiliency in preadolescents living in Mexico. The current study aim is to determine the impact of coping strategies and daily stressors on anxiety and resilience. Daily stressors, coping strategy use, anxiety symptoms, and resilience were assessed in a sample of 98 students (age 9-13) from two schools serving similar socioeconomic areas in Ciudad Juarez, Mexico. The relationship was analyzed using structural equation modeling (SEM) to better account for the influence of coping daily stressors, gender, and age on both anxiety and resilience. The proposed model had excellent indices of model fit and revealed a positive relationship between daily stressors and levels of anxiety. Non-productive coping strategies were also associated with higher levels of anxiety while the relying on others strategy associated with less anxiety. Productive coping and non-productive coping strategies were associated with greater resiliency. Our findings parallel other findings from the literature, however, in a sample from Mexico. The findings suggest that preadolescents use different coping strategies to effectively manage daily stressors, and that anxiety may influence resiliency., Author(s): Verónica Portillo-Reyes [sup.1] , John W. Capps [sup.2] , Yolanda Loya-Mèndez [sup.3] , Gilberto Reyes-Leal [sup.4] , Juan Quiñones-Soto [sup.5] Author Affiliations: (1) grid.441213.1, 0000 0001 1526 9481, Department [...]

Published
2022
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7. The Generalizability of Older Adult Self-Report (OASR) Syndromes of Psychopathology Across 20 Societies

Author

Ivanova, Masha Y, Achenbach, Thomas M, Rescorla, Leslie A, Turner, Lori V, Dumas, Julie A, Almeida, Vera, Anafarta-Sendag, Meltem, Bite, Ieva, Boomsma, Dorret I, Caldas, J Carlos, Capps, John William, Chen, Yi-Chuen, Colombo, Paola, da Silva Oliveira, Margareth, Dobrean, Anca, Erol, Nese, Frigerio, Alessandra, Funabiki, Yasuko, Gedutien, Reda, Guðmundsson, Halldór S, Heo, Min Quan, Kim, Young Ah, Lee, Tih-Shih, Leite, Manuela, Liu, Jianghong, Markovic, Jasminka, Misiec, Monika, Müller, Marcus, Oh, Kyung Ja, Portillo-Reyes, Verónica, Retz, Wolfgang, Sebre, Sandra B, Shi, Shupeng, Sigurðardóttir, Sigurveig H, Simulioien, Roma, Sokoli, Elvisa, Tomasevic, Tanja, Vink, Jacqueline M, ZasĘpa, Ewa, Ivanova, Masha Y, Achenbach, Thomas M, Rescorla, Leslie A, Turner, Lori V, Dumas, Julie A, Almeida, Vera, Anafarta-Sendag, Meltem, Bite, Ieva, Boomsma, Dorret I, Caldas, J Carlos, Capps, John William, Chen, Yi-Chuen, Colombo, Paola, da Silva Oliveira, Margareth, Dobrean, Anca, Erol, Nese, Frigerio, Alessandra, Funabiki, Yasuko, Gedutien, Reda, Guðmundsson, Halldór S, Heo, Min Quan, Kim, Young Ah, Lee, Tih-Shih, Leite, Manuela, Liu, Jianghong, Markovic, Jasminka, Misiec, Monika, Müller, Marcus, Oh, Kyung Ja, Portillo-Reyes, Verónica, Retz, Wolfgang, Sebre, Sandra B, Shi, Shupeng, Sigurðardóttir, Sigurveig H, Simulioien, Roma, Sokoli, Elvisa, Tomasevic, Tanja, Vink, Jacqueline M, and ZasĘpa, Ewa

Abstract

OBJECTIVES: As the world population ages, psychiatrists will increasingly need instruments for measuring constructs of psychopathology that are generalizable to diverse elders. The study tested whether syndromes of co-occurring problems derived from self-ratings of psychopathology by US elders would fit self-ratings by elders in 19 other societies.METHODS/DESIGN: The Older Adult Self-Report (OASR) was completed by 12,826 60- to 102-year-olds in 19 societies from North and South America, Asia, and Eastern, Northern, Southern, and Western Europe, plus the US. Individual and multi-group confirmatory factor analyses (CFAs) tested the fit of the 7-syndrome OASR model, consisting of the Anxious/Depressed, Worries, Somatic Complaints, Functional Impairment, Memory/Cognition Problems, Thought Problems, and Irritable/Disinhibited syndromes.RESULTS: In individual CFAs, the primary model fit index showed good fit for all societies, while the secondary model fit indices showed acceptable to good fit. The items loaded strongly on their respective factors, with a median item loading of .63 across the 20 societies; and 98.7% of the loadings were statistically significant. In multi-group CFAs, 98% of items demonstrated approximate or full metric invariance. Fifteen percent of items demonstrated approximate or full scalar invariance and another 59% demonstrated scalar invariance across more than half of societies.CONCLUSIONS: The findings supported the generalizability of OASR syndromes across societies. The seven syndromes offer empirically-based clinical constructs that are relevant for elders of different backgrounds. They can be used to assess diverse elders, and as a taxonomic framework to facilitate communication, services, research and training in geriatric psychiatry. This article is protected by copyright. All rights reserved.

Published
2020
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8. Older adult psychopathology: international comparisons of self-reports, collateral reports, and cross-informant agreement

Author

Rescorla, L.A., primary, Ivanova, M.Y., additional, Achenbach, T.M., additional, Almeida, Vera, additional, Anafarta-Sendag, Meltem, additional, Bite, Ieva, additional, Caldas, J. Carlos, additional, Capps, John William, additional, Chen, Yi-Chuen, additional, Colombo, Paola, additional, da Silva Oliveira, Margareth, additional, Dobrean, Anca, additional, Erol, Nese, additional, Frigerio, Alessandra, additional, Funabiki, Yasuko, additional, Gedutienė, Reda, additional, Guðmundsson, Halldór S., additional, Heo, Min Quan, additional, Kim, Young Ah, additional, Lee, Tih-Shih, additional, Leite, Manuela, additional, Liu, Jianghong, additional, Markovic, Jasminka, additional, Misiec, Monika, additional, Müller, Marcus, additional, Oh, Kyung Ja, additional, Portillo-Reyes, Verónica, additional, Retz, Wolfgang, additional, Sebre, Sandra B., additional, Shi, Shupeng, additional, Sigurðardóttir, Sigurveig H., additional, Šimulionienė, Roma, additional, Sokoli, Elvisa, additional, Milijasevic, Dragana, additional, and Zasępa, Ewa, additional

Published
2020
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9. The generalizability of Older Adult Self‐Report (OASR) syndromes of psychopathology across 20 societies

Author

Ivanova, Masha Y., primary, Achenbach, Thomas M., additional, Rescorla, Leslie A., additional, Turner, Lori V., additional, Dumas, Julie A., additional, Almeida, Vera, additional, Anafarta‐Sendag, Meltem, additional, Bite, Ieva, additional, Boomsma, Dorret I., additional, Caldas, J. Carlos, additional, Capps, John W., additional, Chen, Yi‐Chuen, additional, Colombo, Paola, additional, Silva Oliveira, Margareth, additional, Dobrean, Anca, additional, Erol, Nese, additional, Frigerio, Alessandra, additional, Funabiki, Yasuko, additional, Gedutienė, Reda, additional, Guðmundsson, Halldór S., additional, Heo, Min Quan, additional, Kim, Young Ah, additional, Lee, Tih‐Shih, additional, Leite, Manuela, additional, Liu, Jianghong, additional, Markovic, Jasminka, additional, Misiec, Monika, additional, Müller, Marcus, additional, Oh, Kyung Ja, additional, Portillo‐Reyes, Verónica, additional, Retz, Wolfgang, additional, Sebre, Sandra B., additional, Shi, Shupeng, additional, Sigurðardóttir, Sigurveig H., additional, Šimulionienė, Roma, additional, Sokoli, Elvisa, additional, Tomasevic, Tanja, additional, Vink, Jacqueline M., additional, and Zasępa, Ewa, additional

Published
2020
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11. Relación del índice de masa corporal con felicidad, autoestima y depresión en adultos jóvenes / The relationship between body mass index and happiness, self-esteem, and depression in young adults

Author

Avitia, Graciela Cristina, Portillo Reyes, Verónica, Reyes Leal, Gilberto, Loya Méndez, Yolanda, Avitia, Graciela Cristina, Portillo Reyes, Verónica, Reyes Leal, Gilberto, and Loya Méndez, Yolanda

Abstract

Obesity is a condition with psychological repercussions, hence the importance of identifying psychological and behavioral traits of those afflicted by it. The objective of this work is to analyze happiness, depression, and self-esteem levels in people with normal weight (NP) and overweight/obesity (SO). The sample was comprised of 151 students from the Universidad Autónoma de Ciudad Juárez (UACJ) with an average age of 21.44 years. Results show a significantly higher score in positive sense of life and personal realization in the SO group in comparison with the NP group. Nonetheless, no significant difference was found in happiness and depression levels. These results part away from those of other existing research which might suggest that people with SO do not experience lack of acceptance from their social environment, a factor normally associated with unhappiness in people with obesity., La obesidad es una enfermedad con repercusión psicológica, por lo que es importante reconocer los rasgos psicológicos y de comportamiento de quienes la padecen. El objetivo de este trabajo es analizar los niveles de felicidad, autoestima y depresión en individuos con normopeso (NP) y con sobrepeso/obesidad (SO). La muestra estuvo constituida por 151 alumnos de la Universidad Autónoma de Ciudad Juárez (UACJ) con una media de edad de 21.44 años. Los resultados mostraron que el grupo de SO tuvo puntuaciones significativamente más elevadas en sentido positivo de la vida y realización personal, en comparación con el grupo de NP. Sin embargo, no se encontraron diferencias significativas en autoestima y depresión. Estos resultados no coinciden con los de otras investigaciones y podrían ser explicados por el grado de aceptación en el entorno social hacia las personas con obesidad, las estrategias de afrontamiento y la prevalencia de obesidad y sobrepeso entre otras variables con las que se ha asociado la relación obesidad/infelicidad.AbstractObesity is a condition with psychological repercussions, hence the importance of identifying psychological and behavioral traits of those afflicted by it. The objective of this work is to analyze happiness, depression, and self-esteem levels in people with normal weight (NP) and overweight/obesity (SO). The sample was comprised of 151 students from the Universidad Autónoma de Ciudad Juárez (UACJ) with an average age of 21.44 years. Results show a significantly higher score in positive sense of life and personal realization in the SO group in comparison with the NP group. Nonetheless, no significant difference was found in happiness and depression levels. These results part away from those of other existing research which might suggest that people with SO do not experience lack of acceptance from their social environment, a factor normally associated with unhappiness in people with obesity.

Published
2018

14. Perfiles psicopatológicos de obesos y desnutridos medidos con el CBCL/6-18

Author

Portillo-Reyes, Verónica, Pérez-García, Miguel, Loya-Méndez, Yolanda, Hidalgo Ruzzante, Natalia, and Puente, Antonio

Subjects
Desnutrición, Children psychopathology, Psicopatologias en niños, Obesidad, Obesity, Malnourished
Abstract

Los objetivos de este trabajo fueron definir los trastornos psicopatológicos más comunes asociados a la obesidad y a la desnutrición, así como establecer el grupo de referencia normativo al cual pertenece México en la escala Child Behavior Checklist 6-18 (CBCL/6-18). Este fue un estudio transversal de diseño cuasiexperiemental. Se utilizó la información de 125 niños de escuelas públicas de Ciudad Juárez, Chihuahua, México, en estados de desnutrición, obesidad y normopeso, obtenida mediante las 113 preguntas relacionadas con el comportamiento de niños, que contiene el CBCL 6-18. Por medio de análisis de varianzas se estudiaron las posibles diferencias entre los grupos. Encontramos que nuestra muestra mexicana, pertenece al grupo normativo de referencia tres; las diferencias más significativas se encuentran en el grupo de obesos en la escala de problemas internalizados específicamente en ansiedad/depresión, y en el total de problemas. This paper sought to define the most common psychopathological disorders associated with obese and malnourished children, and establish the normative group to which Mexico belongs in the Child Behavior Checklist 6-18(CBCL/6-18). This was a cross-sectional study of cuasiexperimental design. CBCL/6-18 data from 125 children from public school in Ciudad Juárez, Chihuahua, México were categorized into obese, malnourished and normal nutrition states. The 113 questions related to the behavior of children of the CBCL 6-18 through variance analysis were used to explore the possible differences between groups. Our Mexican children sample belongs to the normative group three. We found that the major differences were in internalized problems, specifically in anxiety/depression, and on Total Problems with the obese group.

Published
2016

15. Variantes genotípicas del SNP-19 del gen de la CAPN 10 y su relación con la diabetes mellitus tipo 2 en una población de Ciudad Juárez, México

Author

Loya Méndez, Yolanda, Reyes Leal, Gilberto, Sánchez González, Adriana, Portillo Reyes, Verónica, Reyes Ruvalcaba, David, and Bojórquez Rangel, Guillermo

Subjects
Diabetes Mellitus type 2, Marcador molecular, CAPN10 gene SNP-19, Diabetes Mellitus tipo 2, Calpaína-10, Calpain-10, Molecular marker, SNP-19 del gen CAPN10, Genes candidatos, Candidate genes
Abstract

Introducción: La diabetes mellitus (DM) tipo 2 es una patología común de origen multifactorial cuyas bases genéticas exactas se desconocen aún; diversos estudios sugieren que los polimorfismos de nucleótido único (SNPs) en el gen CAPN10 (Locus 2q37.3) podrían participar en su desarrollo, incluyendo el polimorfismo de inserción/deleción SNP-19 (2R-3R). Objetivo: Determinar la relación entre el polimorfismo SNP-19 y la presencia de DM tipo 2 en una población de Ciudad Juárez. Métodos: Se seleccionaron 107 individuos: 43 diabéticos tipo 2 (casos) y 64 no diabéticos sin antecedentes heredo-familiares de DM tipo 2 en primer grado (control). Se realizó estudio antropométrico y perfil bioquímico de lípidos, lipoproteínas y glucosa sérica. Se extrajo ADN de linfocitos de sangre periférica y se amplificó mediante la técnica de reacción en cadena de la polimerasa (PCR). Se analizaron los genotipos del polimorfismo SNP-19 del gen CAPN10 por análisis electroforético en geles de agarosa. Se calcularon las frecuencias genotípicas y alélicas y se realizaron pruebas de equilibrio de Hardy-Weinberg (GenAlEx 6.4). Resultados: El análisis mediante la prueba X² identificó diferencias en los genotipos entre casos y control, con una mayor frecuencia del genotipo homocigoto 3R del SNP-19 en el grupo de casos (0.418) respecto al grupo control (0.265). El genotipo 2R/3R presentó relación con valores elevados de peso, índice de masa corporal y perímetros de cintura y cadera; pero solo en el grupo de diabéticos (P=< 0.05). Conclusión: Los resultados de esta investigación sugieren la participación del SNP-19 del gen CAPN10 en el desarrollo de DM tipo 2 en la población estudiada. Introduction: Diabetes Mellitus (DM) type 2 is a common pathology with multifactorial etiology, which exact genetic bases remain unknown. Some studies suggest that single nucleotides polymorphisms (SNPs) in the CAPN10 gene (Locus 2q37.3) could be associated with the development of this disease, including the insertion/deletion polymorphism SNP-19 (2R-3R). Objective: The present study determined the association between the SNP-19 and the risk of developing DM type 2 in Ciudad Juarez population. Methodology: For this study 107 participants were selected: 43 diabetics type 2 (cases) and 64 non diabetics with no family history of DM type 2 in first grade (control). Anthropometric studies were realized as well as lipids, lipoproteins and serum glucose biochemical profiles. The genotypification of SNP-19 was performed using peripheral blood lymphocytes DNA, polymerase chain reactions (PCR), and electrophoretic analysis in agarose gels. Once obtained the genotypic and allelic frequencies, the Hardy-Weinberg equilibrium test (GenAlEx 6.4) was also performed. Results: Using the X² analysis it was identified the genotypic differences between cases and control with higher frequency of the homozygous genotype 3R of SNP-19 in the cases group (0.418) compared to control group (0.265). Also, it was observed an association between genotype 2R/3R with elevated weight, body mass index, and waist and hip circumferences, but only in the diabetic group (P=< 0.05). Conclusion: The findings in this study suggest that SNP-19 in CAPN10 may participate in the development of DM type 2 in the studied population.

Published
2015

16. Variantes genotípicas del SNP-19 del gen de la CAPN 10 y su relación con la diabetes mellitus tipo 2 en una población de Ciudad Juárez, México

Author

Loya Méndez,Yolanda, Reyes Leal,Gilberto, Sánchez González,Adriana, Portillo Reyes,Verónica, Reyes Ruvalcaba,David, and Bojórquez Rangel,Guillermo

Subjects
Marcador molecular, Diabetes Mellitus tipo 2, Calpaína-10, SNP-19 del gen CAPN10, Genes candidatos
Abstract

Introducción: La diabetes mellitus (DM) tipo 2 es una patología común de origen multifactorial cuyas bases genéticas exactas se desconocen aún; diversos estudios sugieren que los polimorfismos de nucleótido único (SNPs) en el gen CAPN10 (Locus 2q37.3) podrían participar en su desarrollo, incluyendo el polimorfismo de inserción/deleción SNP-19 (2R-3R). Objetivo: Determinar la relación entre el polimorfismo SNP-19 y la presencia de DM tipo 2 en una población de Ciudad Juárez. Métodos: Se seleccionaron 107 individuos: 43 diabéticos tipo 2 (casos) y 64 no diabéticos sin antecedentes heredo-familiares de DM tipo 2 en primer grado (control). Se realizó estudio antropométrico y perfil bioquímico de lípidos, lipoproteínas y glucosa sérica. Se extrajo ADN de linfocitos de sangre periférica y se amplificó mediante la técnica de reacción en cadena de la polimerasa (PCR). Se analizaron los genotipos del polimorfismo SNP-19 del gen CAPN10 por análisis electroforético en geles de agarosa. Se calcularon las frecuencias genotípicas y alélicas y se realizaron pruebas de equilibrio de Hardy-Weinberg (GenAlEx 6.4). Resultados: El análisis mediante la prueba X² identificó diferencias en los genotipos entre casos y control, con una mayor frecuencia del genotipo homocigoto 3R del SNP-19 en el grupo de casos (0.418) respecto al grupo control (0.265). El genotipo 2R/3R presentó relación con valores elevados de peso, índice de masa corporal y perímetros de cintura y cadera; pero solo en el grupo de diabéticos (P=< 0.05). Conclusión: Los resultados de esta investigación sugieren la participación del SNP-19 del gen CAPN10 en el desarrollo de DM tipo 2 en la población estudiada.

Published
2015

17. Malnutrición y rendimiento neuropsicológico en niños mexicanos

Author

Portillo Reyes, Verónica, Universidad de Granada. Departamento de Personalidad, Evaluación y Tratamiento Psciológico, Pérez García, Miguel, Puente, Antonio E., and Loya Méndez, Yolanda

Subjects
612.39, Desnutrición, Nutrición, Neuropsicología, Niños
Abstract

Tesis Univ. Granada. Departamento de Personalidad, Evaluación y Tratamiento Psciológico. Leída el 3 de noviembre de 2011

Published
2012

18. Cravings, sugar and fat consumption as determinant factors of obesity in young adults in Juarez City.

Author

Cristina Avitia, Graciela, Loya Méndez, Yolanda, Portillo Reyes, Verónica, Reyes Leal, Gilberto, Capps IV, John W., and Avitia, Graciela Cristina

Subjects
*OBESITY, *OVERWEIGHT persons, *DESIRE, *FOOD consumption, *SUGAR content of food, *FAT content of food
Abstract

Introduction: obesity is a global health epidemic and understanding its causes is essential for successful treatment and prevention. Cravings have been associated with the excessive consumption of sugars and fats, and addictive eating behavior.Objective: to determine the strength of the relationship between cravings, the consumption of sugar and fat, and its impact on body composition as determined via body mass index (BMI), body fat percentage (BFP) and waist circumference (WC) in a sample of Mexicans who reside close to the México-U.S. border.Methods: the sample was comprised of 159 young adults with a mean age of 27.96 ± 6.19, 45.9% of which were male, and all residents of Ciudad Juarez, Mexico. Cravings were measured using Trait and State Food Cravings Questionnaires. The consumption of sugars and fats was determined via a 24-hour recall of foods consumed and a food consumption frequency questionnaire.Results: it was demonstrated that BMI and BFP were positively associated with responses to the craving questionnaires and WC with fat consumption. Additionally, higher fat consumption was positively associated with higher rates of obesity.Conclusions: the results demonstrate the need to identify the presence of cravings and integrate such measures for effective prevention and treatment of obesity. [ABSTRACT FROM AUTHOR]

Published
2018
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19. Older adult psychopathology: international comparisons of self-reports, collateral reports, and cross-informant agreement.

Author

Rescorla LA, Ivanova MY, Achenbach TM, Almeida V, Anafarta-Sendag M, Bite I, Caldas JC, Capps JW, Chen YC, Colombo P, da Silva Oliveira M, Dobrean A, Erol N, Frigerio A, Funabiki Y, Gedutienė R, Guðmundsson HS, Heo MQ, Kim YA, Lee TS, Leite M, Liu J, Markovic J, Misiec M, Müller M, Oh KJ, Portillo-Reyes V, Retz W, Sebre SB, Shi S, Sigurðardóttir SH, Šimulionienė R, Sokoli E, Milijasevic D, and Zasępa E

Subjects
Aged, Analysis of Variance, Humans, Self Report, Checklist, Psychopathology
Abstract

Objectives: To conduct international comparisons of self-reports, collateral reports, and cross-informant agreement regarding older adult psychopathology., Participants: We compared self-ratings of problems (e.g. I cry a lot ) and personal strengths (e.g. I like to help others ) for 10,686 adults aged 60-102 years from 19 societies and collateral ratings for 7,065 of these adults from 12 societies., Measurements: Data were obtained via the Older Adult Self-Report (OASR) and the Older Adult Behavior Checklist (OABCL; Achenbach et al ., )., Results: Cronbach's alphas were .76 (OASR) and .80 (OABCL) averaged across societies. Across societies, 27 of the 30 problem items with the highest mean ratings and 28 of the 30 items with the lowest mean ratings were the same on the OASR and the OABCL. Q correlations between the means of the 0-1-2 ratings for the 113 problem items averaged across all pairs of societies yielded means of .77 (OASR) and .78 (OABCL). For the OASR and OABCL, respectively, analyses of variance (ANOVAs) yielded effect sizes (ESs) for society of 15% and 18% for Total Problems and 42% and 31% for Personal Strengths, respectively. For 5,584 cross-informant dyads in 12 societies, cross-informant correlations averaged across societies were .68 for Total Problems and .58 for Personal Strengths. Mixed-model ANOVAs yielded large effects for society on both Total Problems (ES = 17%) and Personal Strengths (ES = 36%)., Conclusions: The OASR and OABCL are efficient, low-cost, easily administered mental health assessments that can be used internationally to screen for many problems and strengths.

Published
2022
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20. [SNP-19 genotypic variants of CAPN10 gene and its relation to diabetes mellitus type 2 in a population of Ciudad Juarez, Mexico].

Author

Loya Méndez Y, Reyes Leal G, Sánchez González A, Portillo Reyes V, Reyes Ruvalcaba D, and Bojórquez Rangel G

Subjects
Adult, Aged, Case-Control Studies, Female, Gene Frequency, Genotype, Humans, Male, Mexico epidemiology, Middle Aged, Calpain genetics, Diabetes Mellitus, Type 2 epidemiology, Diabetes Mellitus, Type 2 genetics, Polymorphism, Single Nucleotide genetics
Abstract

Introduction: Diabetes Mellitus (DM) type 2 is a common pathology with multifactorial etiology, which exact genetic bases remain unknown. Some studies suggest that single nucleotides polymorphisms (SNPs) in the CAPN10 gene (Locus 2q37.3) could be associated with the development of this disease, including the insertion/deletion polymorphism SNP-19 (2R→3R)., Objective: The present study determined the association between the SNP-19 and the risk of developing DM type 2 in Ciudad Juarez population., Methodology: For this study 107 participants were selected: 43 diabetics type 2 (cases) and 64 non diabetics with no family history of DM type 2 in first grade (control). Anthropometric studies were realized as well as lipids, lipoproteins and serum glucose biochemical profiles. The genotypification of SNP-19 was performed using peripheral blood lymphocytes DNA, polymerase chain reactions (PCR), and electrophoretic analysis in agarose gels. Once obtained the genotypic and allelic frequencies, the Hardy-Weinberg equilibrium test (GenAlEx 6.4) was also performed., Results: Using the X² analysis it was identified the genotypic differences between cases and control with higher frequency of the homozygous genotype 3R of SNP- 19 in the cases group (0.418) compared to control group (0.265). Also, it was observed an association between genotype 2R/3R with elevated weight, body mass index, and waist and hip circumferences, but only in the diabetic group (P=< 0.05)., Conclusion: The findings in this study suggest that SNP-19 in CAPN10 may participate in the development of DM type 2 in the studied population., (Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.)

Published
2014
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