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4. Comparative evaluation of the antioxidant and anti-inflammatory properties of Musa cavendish and Musa paradisiaca pulp and peel extracts from Guinea.

Author

Diawara, Mamady, Boukhers, Imane, Portet, Karine, Duchamp, Orianne, Morel, Sylvie, Boudard, Frederic, Traore, Lounseny, Michel, Alain, Dhuique-Mayer, Claudie, and Poucheret, Patrick

Subjects
PLANTAIN banana, BANANAS, OXIDANT status, EXTRACTS, ANTI-inflammatory agents
Abstract

Banana is one of the most consumed fruits in the world. Musa cavendish and Musa paradisiaca cultivars differential nutrition-health properties and more specifically their antioxidant and antiinflammatory potential are poorly known. The objective of the present study was to compare the hydroalcoholic dry extracts nutrition-health properties of these two types of Guinea bananas. Total polyphenols contents were evaluated by Folin Ciocalteu method, antioxidant capacity by DPPH, ORAC and Mito-tracker assays. Anti-inflammatory activity was evaluated in vitro on inflammatory macrophages. NO scavenging, NO and cytokines production (TNF-a and IL-6) were assessed. At 1 mg/mL, the extracts showed moderate total polyphenol content. Antioxidant activity potential was depended on the type of extracts. Banana pulps anti-inflammatory effects were demonstrated by the inhibition of NO cell production and NO scavenging suggesting that pulps have moderate antiinflammatory effect as a function of doses (100, 50 and 25 µg/mL). However, none of the extracts inhibited the production of cytokines (TNF-a and IL-6). The present study indicates that Guinea bananas may be considered as an interesting food source of antioxidants associated to a moderate anti-inflammatory potential on specific inflammation markers. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Nutrition, Healthcare Benefits and Phytochemical Properties of Cassava (Manihot esculenta) Leaves Sourced from Three Countries (Reunion, Guinea, and Costa Rica)

Author

Boukhers, Imane, primary, Boudard, Frederic, additional, Morel, Sylvie, additional, Servent, Adrien, additional, Portet, Karine, additional, Guzman, Caroline, additional, Vitou, Manon, additional, Kongolo, Joelle, additional, Michel, Alain, additional, and Poucheret, Patrick, additional

Published
2022
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7. Effect of Elevated Carbon Dioxide Exposure on Nutrition-Health Properties of Micro-Tom Tomatoes

Author

Boufeldja, Linda, primary, Brandt, Dennis, additional, Guzman, Caroline, additional, Vitou, Manon, additional, Boudard, Frederic, additional, Morel, Sylvie, additional, Servent, Adrien, additional, Dhuique-Mayer, Claudie, additional, Ollier, Léa, additional, Duchamp, Orianne, additional, Portet, Karine, additional, Dubos, Christian, additional, and Poucheret, Patrick, additional

Published
2022
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12. Anti-inflammatory properties of desipramine and fluoxetine

Author

Portet Karine, Bichon Florence, Michel Alain, Roumestan Caroline, Detoc Maëlle, Henriquet Corinne, Jaffuel Dany, and Mathieu Marc

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Antidepressants are heavily prescribed drugs and have been shown to affect inflammatory signals. We examined whether these have anti-inflammatory properties in animal models of septic shock and allergic asthma. We also analysed whether antidepressants act directly on peripheral cell types that participate in the inflammatory response in these diseases. Methods The antidepressants desipramine and fluoxetine were compared in vivo to the glucocorticoid prednisolone, an anti-inflammatory drug of reference. In a murine model of lipopolysaccharides (LPS)-induced septic shock, animals received the drugs either before or after injection of LPS. Circulating levels of tumour necrosis factor (TNF)-α and mortality rate were measured. In ovalbumin-sensitized rats, the effect of drug treatment on lung inflammation was assessed by counting leukocytes in bronchoalveolar lavages. Bronchial hyperreactivity was measured using barometric plethysmography. In vitro production of TNF-α and Regulated upon Activation, Normal T cell Expressed and presumably Secreted (RANTES) from activated monocytes and lung epithelial cells, respectively, was analysed by immunoassays. Reporter gene assays were used to measure the effect of antidepressants on the activity of nuclear factor-κB and activator protein-1 which are involved in the control of TNF-α and RANTES expression. Results In the septic shock model, all three drugs given preventively markedly decreased circulating levels of TNF-α and mortality (50% mortality in fluoxetine treated group, 30% in desipramine and prednisolone treated groups versus 90% in controls). In the curative trial, antidepressants had no statistically significant effect, while prednisolone still decreased mortality (60% mortality versus 95% in controls). In ovalbumin-sensitized rats, the three drugs decreased lung inflammation, albeit to different degrees. Prednisolone and fluoxetine reduced the number of macrophages, lymphocytes, neutrophils and eosinophils, while desipramine diminished only the number of macrophages and lymphocytes. However, antidepressants as opposed to prednisolone did not attenuate bronchial hyperreactivity. In vitro, desipramine and fluoxetine dose-dependently inhibited the release of TNF-α from LPS-treated monocytes. In lung epithelial cells, these compounds decreased TNF-α-induced RANTES expression as well as the activity of nuclear factor-κB and activator protein-1. Conclusion Desipramine and fluoxetine reduce the inflammatory reaction in two animal models of human diseases. These antidepressants act directly on relevant peripheral cell types to decrease expression of inflammatory mediators probably by affecting their gene transcription. Clinical implications of these observations are discussed.

Published
2007
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18. Pharmacology of (2S,4Z)-N-[(2S)-2-Hydroxy-2-phenylethyl]-4-(methoxyimino) -1-[(2′-methyl[1,1′-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide, a New Potent and Selective Nonpeptide Antagonist of the Oxytocin Receptor

Author

Cirillo, Rocco, primary, Gillio Tos, Enrico, additional, Schwarz, Matthias K., additional, Quattropani, Anna, additional, Scheer, Alexander, additional, Missotten, Marc, additional, Dorbais, Jerôme, additional, Nichols, Anthony, additional, Borrelli, Francesco, additional, Giachetti, Claudio, additional, Golzio, Lucia, additional, Marinelli, Paolo, additional, Thomas, Russell J., additional, Chevillard, Claude, additional, Laurent, Florence, additional, Portet, Karine, additional, Barberis, Claude, additional, and Chollet, André, additional

Published
2003
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20. New imidazo[1,2-a]pyrazine derivatives with bronchodilatory and cyclic nucleotide phosphodiesterase inhibitory activities

Author

Vitse, Olivier, primary, Laurent, Florence, additional, Pocock, Tristan M., additional, Bénézech, Véronique, additional, Zanik, Lahcen, additional, Elliott, Keith R.F., additional, Subra, Guy, additional, Portet, Karine, additional, Bompart, Jacques, additional, Chapat, Jean-Pierre, additional, Small, Roger C., additional, Michel, Alain, additional, and Bonnet, Pierre-Antoine, additional

Published
1999
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