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Rabbit hemorrhagic disease is a highly contagious and acute fatal disease caused by rabbit hemorrhagic disease virus (RHDV). The first outbreak of RHDV2 in 2020 has posed a serious threat to the rabbit breeding industry in China. An effective and specific detection strategy for RHDV GI.1 (RHDV1) and GI.2 (RHDV2) is urgently needed. In this study, we established a reverse transcription loop‐mediated isothermal amplification (RT‐LAMP)‐CRISPR/Cas12a‐based dual readout portable detection platform. The platform showed excellent specificity to identify RHDV1 and RHDV2 strains and no cross‐reaction with other prevalent pathogens of rabbit. The detection limit for RHDV1 and RHDV2 by RT‐LAMP‐CRISPR/Cas12a could reach 10 copies/μl of the VP60 gene per reaction. Furthermore, 74 clinical samples were detected for both RHDV1 and RHDV2. RT‐LAMP‐CRISPR/Cas12a‐based dual readout portable detection platform showed 25.68% (19/74) RHDV1‐positive samples, 43.24% (32/74) RHDV2‐positive samples, and 8.11% (6/74) RHDV1/RHDV2 double positive samples, respectively. The coincidence rates of detection RHDV1 and RHDV2 between RT‐LAMP‐CRISPR/Cas12a and quantitative real‐time‐polymerase chain reaction (qPCR) were both 97.30%. RT‐LAMP‐CRISPR/Cas12a showed higher sensitivity and detection rate compared with qPCR. Moreover, the results were visible to the naked eye within 1.5 h combined with lateral flow strips (LFSs) and visual fluorescence. The RT‐LAMP‐CRISPR/Cas12a portable platform has the advantages of high sensitivity, specificity, fast, low equipment requirements, which can be used in clinical practice in rural areas and resource‐limited settings. [ABSTRACT FROM AUTHOR]

Medical device-associated infections are a pervasive global healthcare concern, often leading to severe complications. Bacterial biofilms that form on indwelling medical devices, such as catheters, are significant contributors to infections like bloodstream and urinary tract infections. This study addresses the challenge of biofilms on medical devices by introducing a portable antimicrobial catheter insert (PACI) designed to be efficient, biocompatible, and anti-infective. The PACI utilizes nitric oxide (NO), known for its potent antimicrobial properties, to deter bacterial adhesion and biofilm formation. To achieve this, a photoinitiated NO donor, S -nitroso- N -acetylpenicillamine (SNAP), is covalently linked to a polydimethylsiloxane (PDMS) polymer. This design allows for higher NO loading for long-term impact and prevents premature donor leaching, a common challenge with SNAP-blended polymers. The SNAP-PDMS material was applied to a side-glowing fiber optic and connected to a wearable light module emitting 450 nm light, creating a functional antimicrobial insert. Activation of the fiber optic, accomplished with a one-click mechanism, enables real-time NO release, maintaining controlled NO levels for a minimum of 24 hours. The therapeutic levels of NO released via photocatalysis from the PACI demonstrated remarkable efficacy, with >90 % reduction in bacterial viability against S. aureus , S. epidermidis , and P. mirabilis without any cytotoxic impact on mammalian cells. This study underscores the potential of the NO-releasing insert in clinical settings, providing a portable and adaptable solution for preventing catheter-associated infections. Photoactivated nitric oxide (NO)-release levels can be achieved using a wireless and Portable Antimicrobial Catheter Insert (PACI) at the medical device interface. The covalent attachment of the NO donor to the base PDMS polymer enables higher NO loading and prevents premature leaching, ensuring maximum efficiency in eradicating catheter-associated infections. [Display omitted] [ABSTRACT FROM AUTHOR]

Purpose: To report the accuracy and reliability of Cobb angle (CA), axial vertebral rotation (AVR), kyphotic and lordotic angles (KA and LA) measurements on using a new 3D ultrasound (US) system. Methods: Forty participants (34 F, 6 M, aged 14.0 ± 2.3 years) were recruited. The first 20 participants were scanned by the validated US system and the new US system. The other 20 participants were scanned with the new US system only. Two raters (R1 and R2) performed the measurements: R1 has 10 years of experience in radiology but is new in ultrasound scoliosis, while R2 has 30 years of scoliosis experience. All US images were measured twice by R1, and once by R2. Forty posteroanterior and 30 lateral standing radiographs were obtained and measured once by R1. Statistical analysis consisted of mean absolute difference (MAD), intraclass correlation coefficient (ICC (2,1)), and Bland-Altman plots. Results: R1 showed excellent intra-rater and inter-rater reliability for US measurements with ICCs(2,1) ≥ 0.91. The inter-method reliability was good between the two US systems for all parameters with ICCs(2,1) ≥ 0.85 and maximum MAD of 3.4°. The new US showed good reliability and accuracy compared to radiographs for CA, AVR and KA with ICCs(2,1) ≥ 0.81 and maximum MAD of 5.8°, but poor results for LA with ICCs(2,1) of 0.27–0.35 and MADs of 14.0°-15.4°. Conclusion: The new 3D US system showed good reliability and accuracy for CA, AVR and KA measurements, but a large measurement discrepancy on LA. A new measurement method for US LA may need to investigate. [ABSTRACT FROM AUTHOR]

In this study, we investigated the use of novel, home-use and portable biofeedback devices in a remote program for managing chronic pain. In three separate 4-week pilot studies, participants engaged in twice-daily, 10-minute biofeedback sessions, with self-assessed reductions in anxiety and pain levels using the 6-item State-Trait Anxiety Inventory (STAI-6) and Visual Analogue Scale (VAS), respectively, in Studies 2 and 3. Among these 113 (Study 2) and 237 (Study 3) biofeedback sessions, 81 (∼72%) and 130 (∼55%) showed reductions in pain, while 93 (∼82%) and 184 (∼78%) experienced reductions in anxiety. A positive relationship was found between anxiety and pain reduction, indicating that larger reductions in anxiety correspond to larger reductions in pain. In Study 1, only anxiety reductions were measured: across 143 biofeedback sessions, 127 experienced reductions in anxiety (∼89%). Participants in all studies demonstrated reductions in baseline to final results in pain, anxiety, and showed increases in satisfaction and recovery. Our results provide strong evidence that portable biofeedback devices can enhance pain management programs by helping to alleviate anxiety and pain in individuals living with chronic conditions. This study can provide a basis for the integration of biofeedback devices into the expanding research of lifestyle and integrative medicine.

Oil content, protein, glucosinolates, and internal qualities are required to be detected during harvesting, transportation, storage, and sale of rapeseed. In this study, a portable device was designed to detect the rapeseed internal quality using near-infrared spectroscopy, in order to realize the multi-index, portable, and rapid non-destructive testing. The hardware was integrated with the dimensions of 246 mm × 128 mm × 127 mm, such as a mini spectrometer, an LCD touchscreen, and a Raspberry Pi processor. The device was operated stably outdoors for 6 hours. The 65 varieties of rapeseed were sampled from different production areas. Diffuse reflectance spectra were then collected from 900 to 1700nm. The wavelength stability tests were carried out to determine a stable spectral region from 900 to 1633nm. Data was divided using KS, SPXY, and Random number. The dataset division was obtained with R² as the index, where the KS was used for the oil content and protein, while the random numbers were for the glucosinolates, erucic acid, and moisture content. Various methods of data smoothing were evaluated with data smoothness as the index, such as SNV, SG, MSC, D1, and D2. SG smoothing (5-window, and 3rd order) was determined as the best preprocessing. Cars, Pca, GA, Lars, Uve, and Spa were used as data reduction to explore the best dimension reduction for each physicochemical index. Cars reduced the dimensions of the oil content model by 73%. Pca reduced the dimensions of the protein and erucic acid models by 98%. Thus the predictive accuracy of erucic acid was improved by 31.49%, whereas, the predictive error was reduced by 40.78%. PLS, ANN, CNN, SVR, and ELM models were used with RMSE, R2, and MAE as the indices. The calibration model was determined for the oil content using KS+SG+Cars+PLS, for the protein using SPXY+SG+Pca+PLS, for the glucosinolates using Random+SG+PLS, for the moisture content using Random+SG+ELM, and the for erucic acid using Random+SG+Pca+PLS. Model indices were as follows: RMSE, R2, and MAE for the oil content were 1.40, 0.95, 1.16; for the protein 1.46, 0.86, 1.24; for the glucosinolates 20.70, 0.73, 15.73; for the erucic acid 3.63, 0.86, 3.28; for the moisture content 0.36, 0.98, 0.24, respectively. The device was used to collect the spectra from 1 to 7g of rapeseed seven times for the light transmission. Results showed that the absorption error for 3 to 7g was within ±5%. Electronic scales were then removed for direct sample testing during field tests. Five stability tests were conducted at temperatures from 15℃ to 35℃, all of which were within reliable ranges; Stability tests were set as the relative humidity from 40% to 80% and found condensation at 70% relative humidity, which was corrected to maintain stability from 40% to 70% relative humidity. Accuracy tests on the device showed the correlation coefficients (R2 ) for oil content, protein content, glucosinolates, moisture content, and erucic acid between predicted and real sets at 0.932, 0.855, 0.734, 0.968, and 0.761, respectively; RMSE values were 1.35, 1.67, 19.6, 0.34, and 2.96, respectively. Therefore, the device can be expected to perform real-time non-destructive testing of oil content, protein, glucosinolates, moisture content, and erucic acid in rapeseed after safe storage. [ABSTRACT FROM AUTHOR]

Carbon capture and utilization (CCU) has emerged in recent years as a promising decarbonization solution for hard-to-abate industries. Compared to carbon capture and storage (CCS), CCU aims not for the storage of carbon dioxide (CO2) but for its use in the production of synthetic fuels, such as synthetic methanol (MeOH). Synthetic MeOH is produced through CO2 hydrogenation, utilizing green hydrogen (H2). Efficient use of CO2 and H2 feedstocks is essential to maximize the carbon reduction potential and energy efficiency of the process. This study performed an optimization analysis on a small-scale, containerized, and portable CO2 hydrogenation unit with a 5 kg MeOH/h production capacity goal, focusing on carbon conversion efficiency (CCE), MeOH yield, H2 consumption, and MeOH purity. The analysis was conducted using Aspen Plus V12. A single-pass model was used first to evaluate an initial reactor design. The reactor was then re-designed according to the results of the gas hourly space velocity (GHSV). The model was then expanded to include a recycling loop and the final reactor design was validated, aiming to maximize overall efficiency. The effects of the operational parameters including the reactor inlet temperature, reactor pressure, thermal fluid temperature, and condensation temperature were examined. The model was then further expanded to include the MeOH distillation process, and the effect of the distillation temperature was examined. The final product of the analysis was a fully-defined and optimized unit, achieving an 87.97% CCE and an 84.99% MeOH yield, consuming 1.11 kg H2/h for the production of 5.01 kg MeOH/h of 99.86 wt% purity. This study can provide valuable information and guidelines for designing small-scale, containerized, and portable CO2 hydrogenation units, which can serve as alternative solutions to address issues of H2 production and transportation related to large-scale installations. [ABSTRACT FROM AUTHOR]

The formation of scale in hot springs and geothermal brines can be detected quickly and easily using optical fiber-based scale sensors. This paper describes the development of a portable sensor for the in situ detection of scale in geothermal water. This sensor was used to detect the formation of calcium carbonate and silica scale and to assess the effectiveness of their inhibitors. The performance of the sensor was evaluated using calcium carbonate scale. In laboratory experiments using both the newly developed sensor and a conventional nonportable sensor, the strength of the transmitted signal was found to decrease significantly as the amount of scale increased. It was considered that this sensor can accurately evaluate only scale formation without being affected by turbidity. The scale that was deposited on each material (optical fiber core, glass plate, polyvinyl chloride (PVC), and SUS304) was observed using a shape analysis laser microscope. Based on these observations, we concluded that this sensor could be used to predict the amount of scale deposited in real time. In situ evaluation of the sensor was conducted at a blowout carbonated hot spring on Rishiri Island, which is located off the coast of Hokkaido, Japan. The results obtained from experiments using hot spring water showed a similar sensor response within a comparable time range as those obtained from the laboratory experiments. The results of this study thus demonstrate that this novel portable scale sensor is suitable for use in geothermal power plants and investigating effectiveness of inhibiters under different conditions. [ABSTRACT FROM AUTHOR]

Summary: Frequency‐domain detection stands as a critical method in remote geophysical exploration; however, its practical application is constrained by the considerable size of the requisite instrumentation. In this paper, we present a compact frequency domain electromagnetic detection system. The integration of intelligent power devices and a novel hardware architecture substantially diminishes the system's dimensions, thereby enhancing its portability. Furthermore, the system design incorporates sinusoidal pulse width modulation and digital phase‐locked amplification to ensure the efficacy of the proposed system. Both the transmitter and receiver system are constrained to dimensions smaller than 1.5 m. Subsequent experimental validation attests to the exemplary hardware performance of the proposed system, with the transmitting voltage of the transmitter circuit attaining 500 V, and the receiver circuit exhibiting a sensitivity as low as 10−8 V. Significantly, this design paradigm not only facilitates the integration of transmitter and receiver systems for frequency‐domain electromagnetic detection but also introduces novel prospects for the application of frequency‐domain electromagnetic detection methods across diverse fields. [ABSTRACT FROM AUTHOR]

Infant formulas and their quality are an extremely important factor for proper growth and development and their composition and nutritional quality are extremely important. Fast, green, and cheap quality analysis methods are definitely desirable. Therefore, the aim of this work was to examine the potential of applying near-infrared (NIR) spectroscopy using two devices: a (i) laboratory NIR analyzer and (ii) portable NIR device. Both devices record the vibrations of molecules in the NIR region of 900–1699 nm. Infant formulas intended for children up to 6 months (n = 6) and for infants with a sensitive digestive system or confirmed allergy to cow's milk proteins (n = 5) were tested. Each infant formula was recorded in the form of powder and in the form of prepared samples corresponding to different ages, according to the instructions on the product declaration. The parameters of color, conductivity, and total dissolved solids (TDS) were also measured. The measured parameters and the chemical composition of infant formulas were associated with NIR spectra and with the application of chemometric tools (principal component analysis (PCA) and partial least squares regression (PLSR)), the similarity and/or difference between the samples was determined and the qualitative/quantitative potential was determined through applications of both devices. Characteristic peaks at certain wavelengths indicate the presence of carbohydrates, proteins, and water were identified and are specific for regular and specific purpose infant formulas. It is precisely these specificities in the composition, which are visible in the NIR spectrum, that make it possible to distinguish samples on a qualitative level. The connection of NIR spectra as input variables and 22 parameters (color, TDS, conductivity, and energy–nutrient composition) as output variables, using PLSR, gave an insight into the quantitative potential, i.e., the possibility of predicting the observed parameters on the basis of NIR spectra (recorded using two devices). The quantitative potential was confirmed on the basis of model parameters that resulted in acceptable values for both NIR devices: the coefficient of determination for the calibration, Rc2 > 0.9, and Range Error Ratio, RER > 6. [ABSTRACT FROM AUTHOR]

As a significant biomarker during the apoptosis process, cytochrome c (Cyt c) is considered as a critical component in the inherent apoptotic pathway, but the simple and portable detection still remains challengeable. In this work, a portable and visual sensing platform for Cyt c was developed based upon the fluorescence quenching of graphene quantum dots (GQDs), which could be finished within a few seconds. Herein, the absorption spectrum of Cyt c matched the emission spectrum of GQDs well, which could cause the fluorescence quenching of GQDs via the inner filter effect (IFE) in the range of 1–50 μg/mL with the limit of detection as low as 0.1 μg/mL. Furthermore, the intracellular Cyt c was imaged to observe the apoptosis process of cancer cells induced by staurosporine. To achieve the portable and visual detection of Cyt c, GQDs were deposited on the filter paper to form the solid platform, which displayed a gradual fluorescence quenching when different concentrations of Cyt c were present. Compared to the conventional methods, the proposed assay is low-cost, fast, portable, and visual, which will be useful for the investigation of mitochondrial dysfunction and apoptotic cell death. [ABSTRACT FROM AUTHOR]

Optical coherence tomography (OCT) is an indispensable instrument in ophthalmology; however, some facilities lack permanent OCT devices. ACT100, a portable SD-OCT system, allows for medical examinations at hospitals that do not have OCT and house calls. We investigated the usefulness of ACT100 by examining the reproducibility of retinal thickness measurements in 35 healthy participants with normal eyes using ACT100 and Cirrus. Using two OCTs, the OCT imaging of both eyes of each subject was performed. Macular retinal thickness was evaluated using the average value in nine lesions of the Early Treatment Diabetic Retinopathy Study (ETDRS) circle. Both models captured images in all cases. In the right eye, mean retinal thickness was significantly lower than in the ACT100 group in all regions; however, the measured values correlated well. The intraclass correlation coefficients showed the same high reliability as the Cirrus. The coefficients of variation (CVs) of both models showed little variation and high stability; however, the CV of ACT100 was significantly higher. The left eye was almost identical. Macular retinal thickness measured using ACT100 showed slightly greater variability than that by Cirrus; the reproducibility was good and correlated well with that of Cirrus. This technique is a suitable alternative to conventional OCT. [ABSTRACT FROM AUTHOR]

Food analysis is significantly important in monitoring food quality and safety for human health. Traditional methods for food detection mainly rely on benchtop instruments and require a certain amount of analysis time, which promotes the development of portable sensors. Portable sensing methods own many advantages over traditional techniques such as flexibility and accessibility in diverse environments, real‐time monitoring, cost‐effectiveness, and rapid deployment. This review focuses on the portable approaches based on carbon dots (CDs) for food analysis. CDs are zero‐dimensional carbon‐based material with a size of less than 10 nm. In the manner of sensing, CDs exhibit rich functional groups, low biotoxicity, good biocompatibility, and excellent optical properties. Furthermore, there are many methods for the synthesis of CDs using various precursor materials. The incorporation of CDs into food science and engineering for enhancing food safety control and risk assessment shows promising prospects. [ABSTRACT FROM AUTHOR]

Copyright of Computer Measurement & Control is the property of Magazine Agency of Computer Measurement & Control and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper introduces a novel portable multi-layer capsule-shaped triboelectric generator (CP-TEG), aimed at optimizing the performance of triboelectric generator technology in terms of miniaturization, modularity, and efficient energy collection. The CP-TEG utilizes a unique multi-layer, stacked structure and an elliptical cylindrical design to increase the effective frictional area and enhance power generation efficiency. Its portable design allows for flexible application in various environments and scenarios. Experimental results demonstrate that the CP-TEG can maintain stable and efficient electrical output under various motion amplitudes and frequencies, and it shows good adaptability to the direction of motion excitation. With a motion amplitude of 7 cm and a frequency of 1.94 Hz, the CP-TEG can charge a 220 μF capacitor to 1.3 V within 100 s. The power generation unit's output voltage and current are more than three times higher than that of traditional single-layer contact-separation mode triboelectric devices. Particularly, its performance in harvesting energy from human motion underscores its effectiveness as a renewable energy solution for wearable devices. Through its innovative structural design and optimized working mechanism, the CP-TEG demonstrates excellent energy collection efficiency and application potential, offering new options for sustainable energy solutions and development. [ABSTRACT FROM AUTHOR]

Neutron diffraction instruments offer a platform for materials science and engineering studies at extended temperature ranges far from ambient. As one of the widely used neutron sample environment types, cryogenic furnaces are usually bulky and complex, and they may need hours of beamtime overhead for installation, configuration, cooling, and sample change, etc. To reduce the overhead time and expedite experiments at the state-of-the-art high-flux neutron source, we developed a low-cost, miniature, and easy-to-use cryogenic environment (77–473 K) for in situ neutron diffraction. A travel-size mug serves for the environment where the samples sit inside. Immediate cooling and an isothermal dwell at 77 K are realized on the sample by direct contact with liquid N2 in the mug. The designed Al inserts serve as the holder of samples and heating elements, alleviate the thermal gradient, and clear neutron pathways. Both a single-sample continuous measurement and multi-sample high-throughput measurements are demonstrated in this environment. High-quality and refinable in situ neutron diffraction patterns are acquired on model materials. The results quantify the orthorhombic-to-cubic phase transformation process in LiMn2O4 and differentiate the anisotropic lattice thermal expansions and bond length evolutions between rhombohedral perovskite oxides with composition variation. [ABSTRACT FROM AUTHOR]

Environmental monitoring of microorganisms is critical for the protection and enhancement of human and ecosystem health. Even though these molecular methods have overtaken traditional culture-based methods and become more accessible, these techniques still require expensive equipment and dedicated facilities to process samples which in the context of a global pandemic, remote sampling areas or low-income countries can be extremely challenging. Sample preparation and sample homogenisation are critical steps for molecular-based techniques, especially for the extraction of DNA and RNA. This study developed a low-cost, open-source, freely available 3D printed homogenizer for the processing of DNA and RNA extraction. The BoSL Beater 3D is a portable device that allows researcher to perform bead-beating steps commonly required for environmental sample extraction protocols in the field and without access to main’s power. The BoSL Beater 3D was tested on filtered wastewater samples and passive samplers exposed to wastewater over a 24-hour period and showed similar or better performance to the traditional laboratory bead beater for both the extraction of DNA and RNA. The cost of this 3D homogeniser is roughly $18 AUD ($296 AUD with the jigsaw, which is roughly 57 times cheaper than a traditional bead beater) and has the added usability of being portable and easily adaptable to any type of jigsaw. In combination to newly developed field extraction kits as well as portable PCR machines, this 3D homogeniser could provide the tool necessary to enable access to molecular testing in remote setting as well as developing countries, which may not have access to fully equipped laboratories, but also allow for timely reporting. In addition, the BoSL Beater 3D, in combination with field extraction kit, can allow more flexibility to researchers while sampling, shipping, and processing DNA and RNA samples, whilst maintaining quality of these samples.

Upper limb movements are essential in everyday life; hand paralysis caused by post-stroke affects the regular lives of patients. To regain hand mobility and motor function, we must perform repetitive exercises. Nowadays, rehabilitation devices are essential to help post-stroke victims exercise and recover from paralysis more quickly. The proposed research developed a 3D-printed portable rehabilitative device for elbow and shoulder movements. This device assists patients with hand impairments in performing repetitive elbow flexion and internal/external rotation of the shoulder. Twenty post-stroke patients (each group of 10) were randomly assigned to the traditional training group or rehabilitation device training group. This study compared the outcomes of the two groups before and after eight weeks of training. Following the therapy, the patient's performance was evaluated using standard clinical tests such as the Fugl-Meyer Assessment (FMA) and Active Range of Motion (AROM) of the elbow and shoulder. The results of the RDT (Rehabilitation Device Training) group were greater than those of the TT (Traditional Training) group, and the p values (p ​

A gas pressure meter-based portable/miniaturized analytical kit was established for rapid and on-site detection of oxalate. Potassium permanganate (KMnO4) and oxalate solution were mixed together in bottle-in-bottle reaction device, a simple oxidation reaction process occurred within 6 min and carbon dioxide (CO2) was generated, inducing the pressure of the sealed bottle changed, which was measured by a portable gas pressure meter. A detectable range of 0.1–6 μmol mL−1 and a detection limit of 0.064 μmol mL−1 were achieved. The proposed analytical method was further used for the analysis of several real samples (spinach, beverages and water samples), with the recoveries of 89–111%. Considering the interferences from the complicated matrix, calcium chloride (CaCl2) was served as a precipitant, oxalate (C2O42−) was precipitated with Ca2+ to form precipitation (CaC2O4), CaC2O4 was then separated from the matrix by centrifuge/filter, eliminating the interferences. It is a rapid, easy-used and interference-free analytical system/device for oxalate on-site and real time analysis.

The article discusses research in which dermatologists screened patients with psoriatic arthritis (PsA) using a VSCAN air handheld ultrasound device. The study assessed the accuracy of visual analogue scale diagnosis of PsA, PsA sensitivity and specificity based GErman Psoriasis ARthritis Diagnostic questionnaire scores, and entheseal tenderness.

Abstract This study aimed on the one hand to clarify the quality, authenticity, safety, and other issues related to products of the anabolic-androgenic steroid methandienone advertised on the Internet and personally imported to Japan and on the other hand to evaluate the use of two portable Raman spectrometers in identifying the active pharmaceutical ingredient (API). The study found that all n = 15 samples purchased from 14 websites were problematic regarding their package, labeling, and/or content. Specifically, one sample (6.7%) was confirmed falsified, twelve samples (80%) were found either to be falsified or unlicensed as pharmaceutical product, and two samples (13.3%) were received without information on the manufacturers’ physical address or country of origin, with one sample (6.7%) having no labeling or other accompanying information at all. Both Raman spectrometers were able to identify the API in all samples as confirmed and quantified by ultra-high-performance liquid chromatography–Fourier transform mass spectrometry. Twelve samples contained on average less than 90% of the declared API content. By contacting national regulatory authorities in 44 countries, methandienone products were found to be approved in 1 country and not approved in 21 countries. To prevent health hazards and abuse, measures against the acquisition of anabolic-androgenic steroids from unknown sources are required. Portable Raman spectrometers may be suitable for the non-destructive and quick identification of methandienone in tablets. Graphical Abstract

This study aimed on the one hand to clarify the quality, authenticity, safety, and other issues related to products of the anabolic-androgenic steroid methandienone advertised on the Internet and personally imported to Japan and on the other hand to evaluate the use of two portable Raman spectrometers in identifying the active pharmaceutical ingredient (API). The study found that all n = 15 samples purchased from 14 websites were problematic regarding their package, labeling, and/or content. Specifically, one sample (6.7%) was confirmed falsified, twelve samples (80%) were found either to be falsified or unlicensed as pharmaceutical product, and two samples (13.3%) were received without information on the manufacturers' physical address or country of origin, with one sample (6.7%) having no labeling or other accompanying information at all. Both Raman spectrometers were able to identify the API in all samples as confirmed and quantified by ultra-high-performance liquid chromatography–Fourier transform mass spectrometry. Twelve samples contained on average less than 90% of the declared API content. By contacting national regulatory authorities in 44 countries, methandienone products were found to be approved in 1 country and not approved in 21 countries. To prevent health hazards and abuse, measures against the acquisition of anabolic-androgenic steroids from unknown sources are required. Portable Raman spectrometers may be suitable for the non-destructive and quick identification of methandienone in tablets. [ABSTRACT FROM AUTHOR]

As a simple, fast, and non-destructive measuring technology, dielectric spectroscopy is usually used to analyze the dielectric properties of agricultural products and food, and then to predict the main components of materials. However, the large and expensive vector network analyzers (VNA) with expensive analysis software applied in measuring dielectric properties make research limited to the laboratory. To acquire dielectric spectra in situ, a model for solving relative complex permittivity was derived, and its performance was validated. Then, a low-cost portable dielectric spectrometer with a mini VNA, a Raspberry Pi, and a coaxial probe as core parts was developed over the frequency range of 100-3000 MHz. The stability and accuracy of the developed spectrometer were tested using milk and juice. The results indicated that the relative errors of the model were within ±5% for dielectric constant (s') and loss factor (e"). The coefficients of variation of measured e' and e" by the developed spectrometer at 100-3000 MHz were less than 1% and 2%, respectively. Compared with the dielectric properties obtained by using a commercial dielectric measurement system, the relative errors of measured e' and e" were within ±3.4% and ±6.0%, respectively. This study makes fast, non-destructive, and on-site food quality detection using dielectric spectra possible. [ABSTRACT FROM AUTHOR]

This case presents a live birth of a complete "two-way transport IVF" using a portable incubator during the COVID-19 pandemic, allowing the patient to undergo both oocyte collection and embryo transfer in a satellite office located 30 miles, 2-h drive, away from the central IVF laboratory. A 30-year-old patient who lives on Long Island NY, with a history of unexplained infertility and previously failed intra-uterine inseminations (IUI), had a telehealth consultation for IVF. Because of the high prevalence of the COVID-19 virus in Manhattan-NYC where the central IVF laboratory is located, the patient was consented to undergo a two-way transport IVF. She was initiated on a controlled ovarian superovulation protocol, after which follicular aspiration of 11 large follicles was performed in a regular examination room, under local vaginal anesthesia at the satellite office. The follicular fluid aspirates were collected in the usual tubes which were immediately sealed and placed inside a portable incubator. The sperm sample was also produced at the satellite location, washed, and placed in the same incubator. The aspirate tubes and the washed sperm were shipped immediately to the central laboratory. A total of ten oocytes were retrieved, out of which six were mature, leading to three good-quality blastocysts that were cryopreserved. The following month, the patient was prepared for a frozen embryo transfer (FET) cycle at the satellite location. On the day of the FET, two blastocysts were thawed and loaded in a transfer catheter in the central IVF laboratory. The catheter containing the embryos was shipped to the satellite location by an experienced embryologist using the portable incubator. The FET was performed in the same initial examination room. A singleton smooth pregnancy resulted from the FET, leading to the delivery of a healthy baby at term. This novel approach, learned during the pandemic, was able to alleviate the psychological, physical, and financial burdens on the patient, while also carrying the potential to reduce the costs of setting up an IVF laboratory, lowering prices and making IVF available to a larger portion of the population, especially when staffing IVF laboratories could be a major hurdle. [ABSTRACT FROM AUTHOR]

Copyright of CEDRUS is the property of Mediterranean Civilisations Research Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Computer Measurement & Control is the property of Magazine Agency of Computer Measurement & Control and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Lithium is an ideal material for green energy and lightweight alloys, and has been valued by many countries as an important strategic resource. Many hot springs, are rich in Li. However, hot springs are mainly distributed in remote areas such as Xizang and Yunnan, where the cost of sample transportation and laboratory testing is high and the efficiency is low, so the exploration of lithium resources urgently needs the support of on-site analysis technology. Hot spring water generally contains high concentrations of sodium, potassium and other elements, and the matrix effect is significant. In this study, the wavelength of the characteristic Li spectral line was set at 670.78nm. The analytical method for on-site determination of Li in hot spring water samples was established by a self-developed portable Li-K analyzer with a negative filter using the standard curve and standard addition methods. The experimental results show that when the electrolyte is 1.5% hydrochloric acid, the working current is 70mA and the sample flow rate is 3.0mL/min, the detection limit of Li is 4.07μg/L, and the measured precision (RSD) is better than 2%. The hot spring water samples were tested by standard addition, and the spiked recoveries were 81.6% to 115.9%. When the matrix composition of hot spring water samples is simple, accurate analysis results can be obtained by directly using the standard curve method. When the matrix composition of the sample is complex or the matrix concentration is high, the matrix effect can be effectively reduced by the standard addition method, and the analysis results obtained are relatively more accurate, which is suitable for the analysis of lithium content in hot spring water with different matrix types. [ABSTRACT FROM AUTHOR]

A cost-effective noninvasive 2.4 GHz microwave blood glucose sensor is designed and implemented in this study. The special feature of the system is that it can operate independently without any other equipment, and the system is small in size and easy to carry. When the system is powered on and the ring finger is placed on the sensor, the blood glucose level (BGL) can be determined. The system is easy to operate and can be used continuously. For the system, a special sensor element with metamaterial cells and a specific RF-DC rectifier circuit are designed and implemented. An algorithm that can calculate BGL from the sensing voltage generated by detecting the fingertip and programmed to run in the embedded system is developed. Compared with BGL detected by a commercially available invasive blood glucose sensor, the detection error of the proposed sensor is less than 2%. The proposed noninvasive 2.4 GHz microwave blood glucose sensor is very simple and inexpensive, and the measurement results are very close to those of commercially available sensors. [ABSTRACT FROM AUTHOR]

Acute decompensated heart failure and fluid overload are the most common causes of hospitalization in heart failure patients, and often, they contribute to disease progression. Initial treatment encompasses intravenous diuretics although there might be a percentual of patients refractory to this pharmacological approach. New technologies have been developed to perform extracorporeal ultrafiltration in fluid overloaded patients. Current equipment allows to perform ultrafiltration in most hospital and acute care settings. Extracorporeal ultrafiltration is then prescribed and conducted by specialized teams, and fluid removal is planned to restore a status of hydration close to normal. Recent clinical trials and European and North American practice guidelines suggest that ultrafiltration is indicated for patients with refractory congestion not responding to medical therapy. Close interaction between nephrologists and cardiologists may be the key to a collaborative therapeutic effort in heart failure patients. Further studies are today suggesting that wearable technologies might become available soon to treat patients in ambulatory and de-hospitalized settings. These new technologies may help to cope with the increasing demand for the care of chronic heart failure patients. Herein, we provide a state-of-the-art review on extracorporeal ultrafiltration and describe the steps in the development of a new miniaturized system for ultrafiltration, called AD1 (Artificial Diuresis). [ABSTRACT FROM AUTHOR]

In stroke rehabilitation, simple robotic devices hold the potential to increase the training dosage in group therapies and to enable continued therapy at home after hospital discharge. However, we identified a lack of portable and cost-e [ABSTRACT FROM AUTHOR]

Cracks, potholes, and other defects often occur on infrastructure such as bridges, among which cracks are one of the most frequent defects. They have diverse shapes and are difficult to detect. Traditional manual inspection methods are inefficient and have low accuracy, while automated inspection machines are bulky and inconvenient to carry and use. Based on the shortcomings of existing detection technologies, this paper proposes a portable structural surface crack detection system based on the Android platform using a portable handheld image acquisition device. The system captures cracks on the structure's surface and obtains high-definition crack images. Then, these images are transmitted to portable smartphone terminals through Wi-Fi. Next, the image is pre-processed using weighted averaging, grayscale linear transformation, and adaptive median filtering. Then, the improved Canny edge detection algorithm is applied to identify crack information, and the edge segmentation algorithm is used to determine the crack width. Finally, based on camera calibration, the pixels are converted into the length data required for actual measurement. The results show that the system is easy to operate, and it not only has crack storage and tracking functions, but also can effectively measure the crack width on the surface of components. The measurement accuracy of this system reaches the sub-pixel level, and in actual testing, compared with the crack width gauge, the maximum relative error does not exceed 6.25%. [ABSTRACT FROM AUTHOR]

A simple weighable lysimeter was designed, constructed, and calibrated for measuring the water requirements and crop coefficients of shallow-rooted crops. It has a portable weighing mechanism to quantify changes in soil moisture content. The weighing mechanism consists of a horizontal steel bar, a hydraulic car jack, both ends hooked vertical steel bars, a stand, and a digital weighing balance. As the lysimeter's inner tank, a plastic drum with a 55 cm diameter that yields 0.24 m2 of internal area was used. A performance test was conducted, and a rating curve was developed at the beginning of the growing seasons in 2023 and 2024 to evaluate the sensitivity of the weighing mechanism in determining crop water use. Linearity, repeatability, and measurement uncertainty tests were conducted. The linearity error was ±0.04 kg and ±0.03 kg for the years 2023 and 2024, respectively, which is within the allowable limit. The weighing system repeats the measurement perfectly with no error (repeatability error was zero). The combined uncertainty of the measurements was 0.023 kg, representing the cumulative effect of individual errors. The lysimeter weighing system is capable of detecting variations in mass as small as 0.2 mm of moisture content. Therefore, the developed lysimeter can be used to determine water requirements and crop coefficients of shallow-rooted crops for the design and management of irrigation in data-scarce areas of Ethiopia.

The operation of microfluidic devices requires precise and constant fluid flow. Microfluidic systems in low-resource settings require a portable, inexpensive, and electricity-free pumping approach due to the rising demand for microfluidics in point-of-care testing (POCT). Open-source alternatives, employing 3D printing and motors, offer affordability. However, using motors require electrical power, which often relies on external sources, hindering the on-site use of open-source pumps. This study introduces a spring-driven, 3D-printed syringe pump, eliminating the need for an external power source. The syringe pump is operated by the flat spiral spring’s torque. By manually winding up the mainspring, the syringe pump can be operated without electricity. Various flow rates can be achieved by utilizing different syringe sizes and choosing the right gear combinations. All the parts of the syringe pump can be fabricated by 3D printing, requiring no additional components that require electricity. It operates by winding a mainspring and is user-friendly, allowing flow rate adjustments by assembling gears that modulate syringe plunger pushing velocity. The fabrication cost is $25–30 and can be assembled easily by following the instructions. We expect that the proposed syringe pump will enable the utilization of microfluidic technologies in resource-limited settings, promoting the adoption of microfluidics. Detailed information and results are available in the original research paper (https://doi.org/10.1016/j.snb.2024.135289).

Purpose: To evaluate the performance of artificial intelligence (AI) systems embedded in a mobile, handheld retinal camera, with a single retinal image protocol, in detecting both diabetic retinopathy (DR) and more-than-mild diabetic retinopathy (mtmDR). Design: Multicenter cross-sectional diagnostic study, conducted at 3 diabetes care and eye care facilities. Participants: A total of 327 individuals with diabetes mellitus (type 1 or type 2) underwent a retinal imaging protocol enabling expert reading and automated analysis. Methods: Participants underwent fundus photographs using a portable retinal camera (Phelcom Eyer). The captured images were automatically analyzed by deep learning algorithms retinal alteration score (RAS) and diabetic retinopathy alteration score (DRAS), consisting of convolutional neural networks trained on EyePACS data sets and fine-tuned using data sets of portable device fundus images. The ground truth was the classification of DR corresponding to adjudicated expert reading, performed by 3 certified ophthalmologists. Main Outcome Measures: Primary outcome measures included the sensitivity and specificity of the AI system in detecting DR and/or mtmDR using a single-field, macula-centered fundus photograph for each eye, compared with a rigorous clinical reference standard comprising the reading center grading of 2-field imaging protocol using the International Classification of Diabetic Retinopathy severity scale. Results: Of 327 analyzed patients (mean age, 57.0 ± 16.8 years; mean diabetes duration, 16.3 ± 9.7 years), 307 completed the study protocol. Sensitivity and specificity of the AI system were high in detecting any DR with DRAS (sensitivity, 90.48% [95% confidence interval (CI), 84.99%–94.46%]; specificity, 90.65% [95% CI, 84.54%–94.93%]) and mtmDR with the combination of RAS and DRAS (sensitivity, 90.23% [95% CI, 83.87%–94.69%]; specificity, 85.06% [95% CI, 78.88%–90.00%]). The area under the receiver operating characteristic curve was 0.95 for any DR and 0.89 for mtmDR. Conclusions: This study showed a high accuracy for the detection of DR in different levels of severity with a single retinal photo per eye in an all-in-one solution, composed of a portable retinal camera powered by AI. Such a strategy holds great potential for increasing coverage rates of screening programs, contributing to prevention of avoidable blindness. Financial Disclosure(s): F.K.M. is a medical consultant for Phelcom Technologies. J.A.S. is Chief Executive Officer and proprietary of Phelcom Technologies. D.L. is Chief Technology Officer and proprietary of Phelcom Technologies. P.V.P. is an employee at Phelcom Technologies.

Material classification is pivotal across materials science, engineering, and various industrial sectors. Despite the high accuracy of traditional material classification methods, they often entail large, intricate, and costly setups that demand skilled operators. In this study, we introduce the MCT-array, a newly developed compact RF antenna array system measuring $100\times 100 \times 2$ mm, which functions as a transceiver. This device, equipped with 32 receiving antennas and 2 transmitters, leverages dynamic power adjustments to refine material detection accuracy. The study evaluates three machine learning classifiers, namely Support Vector Machine (SVM), Multi-Layer Perceptron (MLP), and Random Forest (RandF) on twelve different materials. MATLAB simulations are initially conducted to identify optimal transceiver configurations. Following the identification of optimal parameters from these simulations, real-world experiments are conducted with the materials positioned 30 cm away from the antenna. Results demonstrate that RandF achieves a material classification accuracy of 94.84%, followed by SVM at 94.5%, and MLP at 94.1%. Detailed analysis further reveals that RandF is the preferred option for tasks demanding the highest levels of accuracy, SVM strikes an optimal balance between processing speed and accuracy, while MLP stands out for its rapid prediction times, making it especially suitable for real-time applications. Integrating an innovative portable RF transceiver with these machine learning models, achieving an impressive average accuracy of over 94%, represents a scalable and effective solution. This innovation holds significant promise for sectors engaged in material classification, particularly in the realms of robotics and automation.

Environmental screening is essential due to the increased occurrence of harmful substances in the environment. Open Meter Duo (OMD) is an open-source field photo/fluorimeter that uses an RGB diode that imitates a color according to the selected wavelength and uses a UV LED from the security kit diode as an excitation light source. The prepared PCB shield with a 3D-printed aperture was connected to Arduino UNO R4 WiFi. This system was used for the fluorescent detection of cholinesterase activity with the indoxyl acetate method. Carbofuran—a toxic pesticide—and donepezil—a drug used to treat Alzheimer’s disease—were tested as model inhibitors of cholinesterase activity. The limit of detection of indoxyl acetate was 11.6 μmol/L, and the IC50 values of the inhibitors were evaluated. This system is optimized for wireless use in field analysis with added cloud support and power source. The time of analysis was 5 min for the fluorimetric assay and 20 min for the optional photometric assay. The time of field operation was approximately 4 h of continuous measurement. This system is ready to be used as a cheap and easy control platform for portable use in drug control and point-of-care testing. [ABSTRACT FROM AUTHOR]

The objective of this research is to devise a tool named Vertical Jump Measurement Portable (VJMP) with the purpose of facilitating practical and efficient measurements of vertical jumps, offering portability for use in diverse settings; concurrently, the research aims to evaluate the precision of VJMP in measuring vertical jumps. Employing research and development methodologies, this study involved the comparison of Vertical Jump Measurement Portable (VJMP) research products with traditional vertical jump measuring instruments. The research enlisted 42 participants who were athletes representing diverse sports disciplines. Data analysis included the application of the Mann-Whitney test to discern any statistically significant differences between the two vertical jump measuring instruments, with a threshold for significance set at p>0.05. The study outcomes revealed no statistically significant distinctions in the data obtained from two vertical jump measuring instruments, as indicated by a p-value of 0.754. This underscores the accuracy of VJMP in gauging vertical jumps. Furthermore, the tool exhibited notable efficiency, requiring a mere 41 seconds for the measurement of an individual. In conclusion, VJMP stands as an accurate and efficient instrument for assessing vertical jumps, thereby making it a viable choice for measurements across diverse sports and facilitating ease of use in practical field settings. [ABSTRACT FROM AUTHOR]

Polymer‐based materials are of high potential for application as active materials in contemporary electronic gadgets. The functionality of such materials is highly dependent on their oxidation state and requires fine control during their synthesis. Owing to that, we have designed a cost‐effective, simple, portable, system for calibration and the detection of the optical and electrical properties of polyaniline loaded on a paper substrate using a smartphone‐based colorimetric sensor. The vapor phase polymerization technique was adopted for preparing polyaniline. Colorimetric measurements of polyaniline‐loaded papers were achieved by estimating the hue, saturation and value (HSV) color parameter values using an open‐source smartphone application called "Color Grab (Color Detection)" during synthesis at different time intervals. The proposed sensor relies on the principle of Beer–Lambert law. The rear camera of the smartphone acts as a sensor and captures the light signal from the samples and provides information to the colorimetric app. The colorimetric results showed a promising correlation between the color parameter values with their electrical properties. The optical absorbance results of all polyaniline‐loaded papers are also in accordance with the H parameter values. The proposed sensor can be used as a portable smartphone‐based point‐of‐care testing kit to bring in‐situ control during synthesis. Highlights: Conducting polymer on flexible cellulose substrate.Smartphone‐based visual colorimetric sensor.Biodegradable and environment‐friendly electronic material.Variation of electrical properties in terms of hue values.Cheap, portable sensor for point‐of‐care testing. [ABSTRACT FROM AUTHOR]

The necessary implementation of decentralized wastewater treatment systems in densely populated rural regions is a viable alternative to constructing a large centralized system. Therefore, this study aims to assess the conceptual feasibility of implementing a portable containerized and decentralized wastewater treatment system as a case study in Palestine that can help in treating wastewater in rural areas efficiently generated by up to 4,000 individuals. The conceptually proposed system is comprised of two stages. The initial stage includes a standalone primary sedimentation tank located outside the container. The subsequent stage consists of a container housing all the equipment utilized in the treatment process beginning with aeration, followed by secondary sedimentation, and ending with filtration and chlorination. Although the system is designed as a single container, in practice, it will consist of two containers with identical units. The second container will ensure continuous operation mode in case of maintenance in the first container. An initial cost evaluation was conducted, and the projected cost for one container is roughly $9,800, which is reasonable. Indeed, adopting this proposed system would result in a significant cost-saving of approximately 40 million dollars compared to the current west wastewater treatment plant in Nablus. Additional research can be undertaken to explore the running cost and the level of efficacy attained. [ABSTRACT FROM AUTHOR]

Water quality monitoring has become more critical in recent years to ensure the availability of clean and safe water from natural aquifers and to understand the evolution of water contaminants across time and space. The conventional water monitoring techniques comprise of sample collection, preservation, preparation, tailed by laboratory testing and analysis with cumbersome wet chemical routes and expensive instrumentation. Despite the high accuracy of these methods, the high testing costs, laborious procedures, and maintenance associated with them don't make them lucrative for end end-users and field testing. As the participation of ultimate stakeholders, that is, common man for water quality and quantity can play a pivotal role in ensuring the sustainability of our aquifers, thus it is essential to develop and deploy portable and user-friendly technical systems for monitoring water sources in real-time or on-site. The present review emphasizes here on possible approaches including optical (absorbance, fluorescence, colorimetric, X-ray fluorescence, chemiluminescence), electrochemical (ASV, CSV, CV, EIS, and chronoamperometry), electrical, biological, and surface-sensing (SPR and SERS), as candidates for developing such platforms. The existing developments, their success, and bottlenecks are discussed in terms of various attributes of water to escalate the essentiality of water quality devices development meeting ASSURED criterion for societal usage. These platforms are also analyzed in terms of their market potential, advancements required from material science aspects, and possible integration with IoT solutions in alignment with Industry 4.0 for environmental application. [ABSTRACT FROM AUTHOR]

Here, an enzyme-free lateral flow aptasensor was designed by target-induced strand-displacement effect and followed by the activation of multi-component nucleic acid enzyme (MNAzyme)-mediated cleavage to enable rapid and portable ochratoxin A (OTA) detection. The substrate was prepared as an oligonucleotide strand modified with magnetic beads (MB) and human chorionic gonadotropin (hCG). The interaction of OTA with the aptamer induces the release of blocking DNA, which hybridized with three separated subunits of DNA, forming a sequence-specific MNAzyme catalytic core. This core subsequently initiated an enzyme-free MNAzyme cleavage reaction in the presence of the Mg2+ cofactor, cleaving a special substrate and releasing both the incomplete MNAzyme catalytic core and hCG-DNA probe. The incomplete MNAzyme catalytic core was then recognized by substrates once again, triggering a cascade recycling cleavage and resulting in the generation of a larger number of hCG-DNA probes. After magnetic enrichment, the free hCG-DNA probes flow through the pregnancy test strip (PTS) to the T line, generating a colorimetric readout that unequivocally confirms the presence of the target OTA. This work leverages the efficient enzyme-free cleavage amplification of MNAzyme and the PTS-based portable detection device, presenting a biosensing strategy with significant potential for sensitive and portable OTA detection. This method exhibited remarkable sensitivity and selectivity for OTA detection, boasting a detection limit of 5 nM. The present study successfully demonstrated the practical application of this method on real samples, offering a viable alternative for rapid and portable detection of mycotoxins. [ABSTRACT FROM AUTHOR]

Heavy metals in soil are dangerous to crop growth and human health, and on-site rapid detection is of great significance for heavy metal investigation and emergency monitoring in soil. The self-developed soil heavy metal on-site rapid detection instrument, which based on laser induced breakdown spectroscopy technology, was used to conduct on-site detection and analysis of the surrounding soil in the mining area. A calibration database was established based on the spectral data of 835 different matrix reference soils, and regression models were established using support vector machine to quantitatively invert the content of heavy metal elements in soil. The full spectral fluctuation obtained on-site detection was within 15%, and the average relative standard deviation of spectral intensity of six elements, including Cd, Cr, Cu, Ni, Pb and Zn, was 6.31%. Compared the detection results with laboratory inductively coupled plasma mass spectrometry analysis, the pearson correlation coefficients(r) of six elements ranged from 0.850 1 to 0.982 9, and over 80% of the detection results were distributed within the ±30% relative error range. The comparative results indicated that the self-developed soil heavy metal detector could meet the needs of rapid on-site detection. [ABSTRACT FROM AUTHOR]