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2. Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study
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Pham, T, Heunks, L, Bellani, G, Madotto, F, Aragao, I, Beduneau, G, Goligher, E, Grasselli, G, Laake, J, Mancebo, J, Penuelas, O, Piquilloud, L, Pesenti, A, Wunsch, H, van Haren, F, Brochard, L, Laffey, J, Abrough, F, Acharya, S, Amin, P, Arabi, Y, Bauer, P, Beitler, J, Berkius, J, Bugedo, G, Camporota, L, Cerny, V, Cho, Y, Clarkson, K, Estenssoro, E, Gritsan, A, Hashemian, S, Hermans, G, Jovanovic, B, Kurahashi, K, Matamis, D, Moerer, O, Molnar, Z, Ozyilmaz, E, Panka, B, Papali, A, Perbet, S, Qiu, H, Razek, A, Rittayamai, N, Roldan, R, Serpa Neto, A, Szuldrzynski, K, Talmor, D, Tomescu, D, Villagomez, A, Zeggwagh, A, Abe, T, Aboshady, A, Acampo-de Jong, M, Adderley, J, Adiguzel, N, Agrawal, V, Aguilar, G, Aguirre, G, Aguirre-Bermeo, H, Ahlstrom, B, Akbas, T, Akker, M, Al Sadeh, G, Alamri, S, Algaba, A, Ali, M, Aliberti, A, Allegue, J, Alvarez, D, Amador, J, Andersen, F, Ansari, S, Apichatbutr, Y, Apostolopoulou, O, Arellano, D, Arica, M, Arikan, H, Arinaga, K, Arnal, J, Asano, K, Asin-Corrochano, M, Avalos Cabrera, J, Avila Fuentes, S, Aydemir, S, Aygencel, G, Azevedo, L, Bacakoglu, F, Badie, J, Baedorf Kassis, E, Bai, G, Balaraj, G, Ballico, B, Banner-Goodspeed, V, Banwarie, P, Barbieri, R, Baronia, A, Barrett, J, Barrot, L, Barrueco-Francioni, J, Barry, J, Bawangade, H, Beavis, S, Beck, E, Beehre, N, Belenguer Muncharaz, A, Belliato, M, Bellissima, A, Beltramelli, R, Ben Souissi, A, Benitez-Cano, A, Benlamin, M, Benslama, A, Bento, L, Benvenuti, D, Bernabe, L, Bersten, A, Berta, G, Bertini, P, Bertram-Ralph, E, Besbes, M, Bettini, L, Beuret, P, Bewley, J, Bezzi, M, Bhakhtiani, L, Bhandary, R, Bhowmick, K, Bihari, S, Bissett, B, Blythe, D, Bocher, S, Boedjawan, N, Bojanowski, C, Boni, E, Boraso, S, Borelli, M, Borello, S, Borislavova, M, Bosma, K, Bottiroli, M, Boyd, O, Bozbay, S, Briva, A, Bruel, C, Bruni, A, Buehner, U, Bulpa, P, Burt, K, Buscot, M, Buttera, S, Cabrera, J, Caccese, R, Caironi, P, Canchos Gutierrez, I, Canedo, N, Cani, A, Cappellini, I, Carazo, J, Cardonnet, L, Carpio, D, Carriedo, D, Carrillo, R, Carvalho, J, Caser, E, Castelli, A, Castillo Quintero, M, Castro, H, Catorze, N, Cengiz, M, Cereijo, E, Ceunen, H, Chaintoutis, C, Chang, Y, Chaparro, G, Chapman, C, Chau, S, Chavez, C, Chelazzi, C, Chelly, J, Chemouni, F, Chen, K, Chena, A, Chiarandini, P, Chilton, P, Chiumello, D, Chou-Lie, Y, Chudeau, N, Cinel, I, Cinnella, G, Clark, M, Clark, T, Clementi, S, Coaguila, L, Codecido, A, Collins, A, Colombo, R, Conde, J, Consales, G, Cook, T, Coppadoro, A, Cornejo, R, Cortegiani, A, Coxo, C, Cracchiolo, A, Crespo Ramirez, M, Crova, P, Cruz, J, Cubattoli, L, Cukurova, Z, Curto, F, Czempik, P, D'Andrea, R, da Silva Ramos, F, Dangers, L, Danguy des Deserts, M, Danin, P, Dantas, F, Daubin, C, Dawei, W, de Haro, C, de Jesus Montelongo, F, De Mendoza, D, de Pablo, R, De Pascale, G, De Rosa, S, Decavele, M, Declercq, P, Deicas, A, del Carmen Campos Moreno, M, Dellamonica, J, Delmas, B, Demirkiran, O, Demirkiran, H, Dendane, T, di Mussi, R, Diakaki, C, Diaz, A, Diaz, W, Dikmen, Y, Dimoula, A, Doble, P, Doha, N, Domingos, G, Dres, M, Dries, D, Duggal, A, Duke, G, Dunts, P, Dybwik, K, Dykyy, M, Eckert, P, Efe, S, Elatrous, S, Elay, G, Elmaryul, A, Elsaadany, M, Elsayed, H, Elsayed, S, Emery, M, Ena, S, Eng, K, Englert, J, Erdogan, E, Ergin Ozcan, P, Eroglu, E, Escobar, M, Esen, F, Esen Tekeli, A, Esquivel, A, Esquivel Gallegos, H, Ezzouine, H, Facchini, A, Faheem, M, Fanelli, V, Farina, M, Fartoukh, M, Fehrle, L, Feng, F, Feng, Y, Fernandez, I, Fernandez, B, Fernandez-Rodriguez, M, Ferrando, C, Ferreira da Silva, M, Ferreruela, M, Ferrier, J, Flamm Zamorano, M, Flood, L, Floris, L, Fluckiger, M, Forteza, C, Fortunato, A, Frans, E, Frattari, A, Fredes, S, Frenzel, T, Fumagalli, R, Furche, M, Fusari, M, Fysh, E, Galeas-Lopez, J, Galerneau, L, Garcia, A, Garcia, M, Garcia, E, Garcia Olivares, P, Garlicki, J, Garnero, A, Garofalo, E, Gautam, P, Gazenkampf, A, Gelinotte, S, Gelormini, D, Ghrenassia, E, Giacomucci, A, Giannoni, R, Gigante, A, Glober, N, Gnesin, P, Gollo, Y, Gomaa, D, Gomero Paredes, R, Gomes, R, Gomez, R, Gomez, O, Gomez, A, Gondim, L, Gonzalez, M, Gonzalez, I, Gonzalez-Castro, A, Gordillo Romero, O, Gordo, F, Gouin, P, Graf Santos, J, Grainne, R, Grando, M, Granov Grabovica, S, Grasso, S, Grasso, R, Grimmer, L, Grissom, C, Gu, Q, Guan, X, Guarracino, F, Guasch, N, Guatteri, L, Gueret, R, Guerin, C, Guerot, E, Guitard, P, Gul, F, Gumus, A, Gurjar, M, Gutierrez, P, Hachimi, A, Hadzibegovic, A, Hagan, S, Hammel, C, Han Song, J, Hanlon, G, Heines, S, Henriksson, J, Herbrecht, J, Heredia Orbegoso, G, Hermon, A, Hernandez, R, Hernandez, C, Herrera, L, Herrera-Gutierrez, M, Hidalgo, J, Hill, D, Holmquist, D, Homez, M, Hongtao, X, Hormis, A, Horner, D, Hornos, M, Hou, M, House, S, Housni, B, Hugill, K, Humphreys, S, Humbert, L, Hunter, S, Hwa Young, L, Iezzi, N, Ilutovich, S, Inal, V, Innes, R, Ioannides, P, Iotti, G, Ippolito, M, Irie, H, Iriyama, H, Itagaki, T, Izura, J, Izza, S, Jabeen, R, Jamaati, H, Jamadarkhana, S, Jamoussi, A, Jankowski, M, Jaramillo, L, Jeon, K, Jeong Lee, S, Jeswani, D, Jha, S, Jiang, L, Jing, C, Jochmans, S, Johnstad, B, Jongmin, L, Joret, A, Junhasavasdikul, D, Jurado, M, Kam, E, Kamohara, H, Kane, C, Kara, I, Karakurt, S, Karnjanarachata, C, Kataoka, J, Katayama, S, Kaushik, S, Kelebek Girgin, N, Kerr, K, Kerslake, I, Khairnar, P, Khalid, A, Khan, A, Khanna, A, Khorasanee, R, Kienhorst, D, Kirakli, C, Knafelj, R, Kol, M, Kongpolprom, N, Kopitko, C, Korkmaz Ekren, P, Kubisz-Pudelko, A, Kulcsar, Z, Kumasawa, J, Kuriyama, A, Kutchak, F, Labarca, E, Labat, F, Laborda, C, Laca Barrera, M, Lagache, L, Landaverde Lopez, A, Lanspa, M, Lascari, V, Le Meur, M, Lee, S, Lee, Y, Lee, J, Lee, W, Legernaes, T, Leiner, T, Lemiale, V, Leonor, T, Lepper, P, Li, D, Li, H, Li, O, Lima, A, Lind, D, Litton, E, Liu, N, Liu, L, Liu, J, Llitjos, J, Llorente, B, Lopez, R, Lopez, C, Lopez Nava, C, Lovazzano, P, Lu, M, Lucchese, F, Lugano, M, Lugo Goytia, G, Luo, H, Lynch, C, Macheda, S, Madrigal Robles, V, Maggiore, S, Magret Iglesias, M, Malaga, P, Mallapura Maheswarappa, H, Malpartida, G, Malyarchikov, A, Mansson, H, Manzano, A, Marey, I, Marin, N, Marin, M, Markman, E, Martin, F, Martin, A, Martin Dal Gesso, C, Martinez, F, Martinez-Fidalgo, C, Martin-Loeches, I, Mas, A, Masaaki, S, Maseda, E, Massa, E, Mattsson, A, Maugeri, J, Mccredie, V, Mccullough, J, Mcguinness, S, Mckown, A, Medve, L, Mei, C, Mellado Artigas, R, Mendes, V, Mervat, M, Michaux, I, Mikhaeil, M, Milagros, O, Milet, I, Millan, M, Minwei, Z, Mirabella, L, Mishra, S, Mistraletti, G, Mochizuki, K, Moghal, A, Mojoli, F, Molin, A, Montiel, R, Montini, L, Monza, G, Mora Aznar, M, Morakul, S, Morales, M, Moreno Torres, D, Morocho Tutillo, D, Motherway, C, Mouhssine, D, Mouloudi, E, Munoz, T, Munoz de Cabo, C, Mustafa, M, Muthuchellappan, R, Muthukrishnan, M, Muttini, S, Nagata, I, Nahar, D, Nakanishi, M, Nakayama, I, Namendys-Silva, S, Nanchal, R, Nandakumar, S, Nasi, A, Nasir, K, Navalesi, P, Naz Aslam, T, Nga Phan, T, Nichol, A, Niiyama, S, Nikolakopoulou, S, Nikolic, E, Nitta, K, Noc, M, Nonas, S, Nseir, S, Nur Soyturk, A, Obata, Y, Oeckler, R, Oguchi, M, Ohshimo, S, Oikonomou, M, Ojados, A, Oliveira, M, Oliveira Filho, W, Oliveri, C, Olmos, A, Omura, K, Orlandi, M, Orsenigo, F, Ortiz-Ruiz De Gordoa, L, Ota, K, Ovalle Olmos, R, Oveges, N, Oziemski, P, Ozkan Kuscu, O, Pachas Alvarado, F, Pagella, G, Palaniswamy, V, Palazon Sanchez, E, Palmese, S, Pan, G, Pan, W, Papanikolaou, M, Papavasilopoulou, T, Parekh, A, Parke, R, Parrilla, F, Parrilla, D, Pasha, T, Pasin, L, Patao, L, Patel, M, Patel, G, Pati, B, Patil, J, Pattnaik, S, Paul, D, Pavesi, M, Pavlotsky, V, Paz, G, Paz, E, Pecci, E, Pellegrini, C, Pena Padilla, A, Perchiazzi, G, Pereira, T, Pereira, V, Perez, M, Perez Calvo, C, Perez Cheng, M, Perez Maita, R, Perez-Araos, R, Perez-Teran, P, Perez-Torres, D, Perkins, G, Persona, P, Petnak, T, Petrova, M, Philippart, F, Picetti, E, Pierucci, E, Piervincenzi, E, Pinciroli, R, Pintado, M, Piraino, T, Piras, S, Piras, C, Pirompanich, P, Pisani, L, Platas, E, Plotnikow, G, Porras, W, Porta, V, Portilla, M, Portugal, J, Povoa, P, Prat, G, Pratto, R, Preda, G, Prieto, I, Prol-Silva, E, Pugh, R, Qi, Y, Qian, C, Qin, T, Qu, H, Quintana, T, Quispe Sierra, R, Quispe Soto, R, Rabbani, R, Rabee, M, Rabie, A, Rahe Pereira, M, Rai, A, Raj Ashok, S, Rajab, M, Ramdhani, N, Ramey, E, Ranieri, M, Rathod, D, Ray, B, Redwanul Huq, S, Regli, A, Reina, R, Resano Sarmiento, N, Reynaud, F, Rialp, G, Ricart, P, Rice, T, Richardson, A, Rieder, M, Rinket, M, Rios, F, Risso Vazquez, A, Riva, I, Rivette, M, Roca, O, Roche-Campo, F, Rodriguez, C, Rodriguez, G, Rodriguez Gonzalez, D, Rodriguez Tucto, X, Rogers, A, Romano, M, Rortveit, L, Rose, A, Roux, D, Rouze, A, Rubatto Birri, P, Ruilan, W, Ruiz Robledo, A, Ruiz-Aguilar, A, Sadahiro, T, Saez, I, Sagardia, J, Saha, R, Saiphoklang, N, Saito, S, Salem, M, Sales, G, Salgado, P, Samavedam, S, Sami Mebazaa, M, Samuelsson, L, San Juan Roman, N, Sanchez, P, Sanchez-Ballesteros, J, Sandoval, Y, Sani, E, Santos, M, Santos, C, Sanui, M, Saravanabavan, L, Sari, S, Sarkany, A, Sauneuf, B, Savioli, M, Sazak, H, Scano, R, Schneider, F, Schortgen, F, Schultz, M, Schwarz, G, Seckin Yucesoy, F, Seely, A, Seiler, F, Seker Tekdos, Y, Seok Chan, K, Serano, L, Serednicki, W, Setten, M, Shah, A, Shah, B, Shang, Y, Shanmugasundaram, P, Shapovalov, K, Shebl, E, Shiga, T, Shime, N, Shin, P, Short, J, Shuhua, C, Siddiqui, S, Silesky Jimenez, J, Silva, D, Silva Sales, B, Simons, K, Sjobo, B, Slessor, D, Smiechowicz, J, Smischney, N, Smith, P, Smith, T, Smith, M, Snape, S, Snyman, L, Soetens, F, Sook Hong, K, Sosa Medellin, M, Soto, G, Souloy, X, Sousa, E, Sovatzis, S, Sozutek, D, Spadaro, S, Spagnoli, M, Spangfors, M, Spittle, N, Spivey, M, Stapleton, A, Stefanovic, B, Stephenson, L, Stevenson, E, Strand, K, Strano, M, Straus, S, Sun, C, Sun, R, Sundaram, V, Sunpark, T, Surlemont, E, Sutherasan, Y, Szabo, Z, Tainter, C, Takaba, A, Tallott, M, Tamasato, T, Tang, Z, Tangsujaritvijit, V, Taniguchi, L, Taniguchi, D, Tarantino, F, Teerapuncharoen, K, Temprano, S, Terragni, P, Terzi, N, Thakur, A, Theerawit, P, Thille, A, Thomas, M, Thungtitigul, P, Thyrault, M, Tilouch, N, Timenetsky, K, Tirapu, J, Todeschini, M, Tomas, R, Tomaszewski, C, Tonetti, T, Tonnelier, A, Trinder, J, Trongtrakul, K, Truwit, J, Tsuei, B, Tulaimat, A, Turan, S, Turkoglu, M, Tyagi, S, Ubeda, A, Vagginelli, F, Valenti, M, Vallverdu, I, Van Axel, A, van den Hul, I, van der Hoeven, H, Van Der Meer, N, Vanhoof, M, Vargas-Ordonez, M, Vaschetto, R, Vascotto, E, Vatsik, M, Vaz, A, Vazquez-Sanchez, A, Ventura, S, Vermeijden, J, Vidal, A, Vieira, J, Vilela Costa Pinto, B, Villagra, A, Villegas Succar, C, Vinorum, O, Vitale, G, Vj, R, Vochin, A, Voiriot, G, Volta, C, von Seth, M, Wajdi, M, Walsh, D, Wang, S, Wardi, G, Ween-Velken, N, Wei, B, Weller, D, Welsh, D, Welters, I, Wert, M, Whiteley, S, Wilby, E, Williams, E, Williams, K, Wilson, A, Wojtas, J, Won Huh, J, Wrathall, D, Wright, C, Wu, J, Xi, G, Xing, Z, Xu, H, Yamamoto, K, Yan, J, Yanez, J, Yang, X, Yates, E, Yazicioglu Mocin, O, Ye, Z, Yildirim, F, Yoshida, N, Yoshido, H, Young Lee, B, Yu, R, Yu, G, Yu, T, Yuan, B, Yuangtrakul, N, Yumoto, T, Yun, X, Zakalik, G, Zaki, A, Zalba-Etayo, B, Zambon, M, Zang, B, Zani, G, Zarka, J, Zerbi, S, Zerman, A, Zetterquist, H, Zhang, J, Zhang, H, Zhang, W, Zhang, G, Zhao, H, Zheng, J, Zhu, B, Zumaran, R, Pham T., Heunks L., Bellani G., Madotto F., Aragao I., Beduneau G., Goligher E. C., Grasselli G., Laake J. H., Mancebo J., Penuelas O., Piquilloud L., Pesenti A., Wunsch H., van Haren F., Brochard L., Laffey J. G., Abrough F., Acharya S. P., Amin P., Arabi Y., Bauer P., Beitler J., Berkius J., Bugedo G., Camporota L., Cerny V., Cho Y. -J., Clarkson K., Estenssoro E., Goligher E., Gritsan A., Hashemian S. M., Hermans G., Heunks L. M., Jovanovic B., Kurahashi K., Matamis D., Moerer O., Molnar Z., Ozyilmaz E., Panka B., Papali A., Perbet S., Qiu H., Razek A. A., Rittayamai N., Roldan R., Serpa Neto A., Szuldrzynski K., Talmor D., Tomescu D., Villagomez A., Zeggwagh A. A., Abe T., Aboshady A., Acampo-de Jong M., Acharya S., Adderley J., Adiguzel N., Agrawal V. K., Aguilar G., Aguirre G., Aguirre-Bermeo H., Ahlstrom B., Akbas T., Akker M., Al Sadeh G., Alamri S., Algaba A., Ali M., Aliberti A., Allegue J. M., Alvarez D., Amador J., Andersen F. H., Ansari S., Apichatbutr Y., Apostolopoulou O., Arellano D., Arica M., Arikan H., Arinaga K., Arnal J. -M., Asano K., Asin-Corrochano M., Avalos Cabrera J. M., Avila Fuentes S., Aydemir S., Aygencel G., Azevedo L., Bacakoglu F., Badie J., Baedorf Kassis E., Bai G., Balaraj G., Ballico B., Banner-Goodspeed V., Banwarie P., Barbieri R., Baronia A., Barrett J., Barrot L., Barrueco-Francioni J. E., Barry J., Bawangade H., Beavis S., Beck E., Beehre N., Belenguer Muncharaz A., Belliato M., Bellissima A., Beltramelli R., Ben Souissi A., Benitez-Cano A., Benlamin M., Benslama A., Bento L., Benvenuti D., Bernabe L., Bersten A., Berta G., Bertini P., Bertram-Ralph E., Besbes M., Bettini L. R., Beuret P., Bewley J., Bezzi M., Bhakhtiani L., Bhandary R., Bhowmick K., Bihari S., Bissett B., Blythe D., Bocher S., Boedjawan N., Bojanowski C. M., Boni E., Boraso S., Borelli M., Borello S., Borislavova M., Bosma K. J., Bottiroli M., Boyd O., Bozbay S., Briva A., Bruel C., Bruni A., Buehner U., Bulpa P., Burt K., Buscot M., Buttera S., Cabrera J., Caccese R., Caironi P., Canchos Gutierrez I., Canedo N., Cani A., Cappellini I., Carazo J., Cardonnet L. P., Carpio D., Carriedo D., Carrillo R., Carvalho J., Caser E., Castelli A., Castillo Quintero M., Castro H., Catorze N., Cengiz M., Cereijo E., Ceunen H., Chaintoutis C., Chang Y., Chaparro G., Chapman C., Chau S., Chavez C. E., Chelazzi C., Chelly J., Chemouni F., Chen K., Chena A., Chiarandini P., Chilton P., Chiumello D., Chou-Lie Y., Chudeau N., Cinel I., Cinnella G., Clark M., Clark T., Clementi S., Coaguila L., Codecido A. J., Collins A., Colombo R., Conde J., Consales G., Cook T., Coppadoro A., Cornejo R., Cortegiani A., Coxo C., Cracchiolo A. N., Crespo Ramirez M., Crova P., Cruz J., Cubattoli L., Cukurova Z., Curto F., Czempik P., D'Andrea R., da Silva Ramos F., Dangers L., Danguy des Deserts M., Danin P. -E., Dantas F., Daubin C., Dawei W., de Haro C., de Jesus Montelongo F., De Mendoza D., de Pablo R., De Pascale G., De Rosa S., Decavele M., Declercq P. -L., Deicas A., del Carmen Campos Moreno M., Dellamonica J., Delmas B., Demirkiran O., Demirkiran H., Dendane T., di Mussi R., Diakaki C., Diaz A., Diaz W., Dikmen Y., Dimoula A., Doble P., Doha N., Domingos G., Dres M., Dries D., Duggal A., Duke G., Dunts P., Dybwik K., Dykyy M., Eckert P., Efe S., Elatrous S., Elay G., Elmaryul A. S., Elsaadany M., Elsayed H., Elsayed S., Emery M., Ena S., Eng K., Englert J. A., Erdogan E., Ergin Ozcan P., Eroglu E., Escobar M., Esen F., Esen Tekeli A., Esquivel A., Esquivel Gallegos H., Ezzouine H., Facchini A., Faheem M., Fanelli V., Farina M. F., Fartoukh M., Fehrle L., Feng F., Feng Y., Fernandez I., Fernandez B., Fernandez-Rodriguez M. L., Ferrando C., Ferreira da Silva M. J., Ferreruela M., Ferrier J., Flamm Zamorano M. J., Flood L., Floris L., Fluckiger M., Forteza C., Fortunato A., Frans E., Frattari A., Fredes S., Frenzel T., Fumagalli R., Furche M. A., Fusari M., Fysh E., Galeas-Lopez J. L., Galerneau L. -M., Garcia A., Garcia M. F., Garcia E., Garcia Olivares P., Garlicki J., Garnero A., Garofalo E., Gautam P., Gazenkampf A., Gelinotte S., Gelormini D., Ghrenassia E., Giacomucci A., Giannoni R., Gigante A., Glober N., Gnesin P., Gollo Y., Gomaa D., Gomero Paredes R., Gomes R., Gomez R. A., Gomez O., Gomez A., Gondim L., Gonzalez M., Gonzalez I., Gonzalez-Castro A., Gordillo Romero O., Gordo F., Gouin P., Graf Santos J., Grainne R., Grando M., Granov Grabovica S., Grasso S., Grasso R., Grimmer L., Grissom C., Gu Q., Guan X. -D., Guarracino F., Guasch N., Guatteri L., Gueret R., Guerin C., Guerot E., Guitard P. -G., Gul F., Gumus A., Gurjar M., Gutierrez P., Hachimi A., Hadzibegovic A., Hagan S., Hammel C., Han Song J., Hanlon G., Heines S., Henriksson J., Herbrecht J. -E., Heredia Orbegoso G. O., Hermon A., Hernandez R., Hernandez C., Herrera L., Herrera-Gutierrez M., Hidalgo J., Hill D., Holmquist D., Homez M., Hongtao X., Hormis A., Horner D., Hornos M. C., Hou M., House S., Housni B., Hugill K., Humphreys S., Humbert L., Hunter S., Hwa Young L., Iezzi N., Ilutovich S., Inal V., Innes R., Ioannides P., Iotti G. A., Ippolito M., Irie H., Iriyama H., Itagaki T., Izura J., Izza S., Jabeen R., Jamaati H., Jamadarkhana S., Jamoussi A., Jankowski M., Jaramillo L. A., Jeon K., Jeong Lee S., Jeswani D., Jha S., Jiang L., Jing C., Jochmans S., Johnstad B. A., Jongmin L., Joret A., Junhasavasdikul D., Jurado M. T., Kam E., Kamohara H., Kane C., Kara I., Karakurt S., Karnjanarachata C., Kataoka J., Katayama S., Kaushik S., Kelebek Girgin N., Kerr K., Kerslake I., Khairnar P., Khalid A., Khan A., Khanna A. K., Khorasanee R., Kienhorst D., Kirakli C., Knafelj R., Kol M. K., Kongpolprom N., Kopitko C., Korkmaz Ekren P., Kubisz-Pudelko A., Kulcsar Z., Kumasawa J., Kuriyama A., Kutchak F., Labarca E., Labat F., Laborda C., Laca Barrera M. A., Lagache L., Landaverde Lopez A., Lanspa M., Lascari V., Le Meur M., Lee S. H., Lee Y. J., Lee J., Lee W. -Y., Legernaes T., Leiner T., Lemiale V., Leonor T., Lepper P. M., Li D., Li H., Li O., Lima A. R., Lind D., Litton E., Liu N., Liu L., Liu J., Llitjos J. -F., Llorente B., Lopez R., Lopez C. E., Lopez Nava C., Lovazzano P., Lu M., Lucchese F., Lugano M., Lugo Goytia G., Luo H., Lynch C., Macheda S., Madrigal Robles V. H., Maggiore S. M., Magret Iglesias M., Malaga P., Mallapura Maheswarappa H., Malpartida G., Malyarchikov A., Mansson H., Manzano A., Marey I., Marin N., Marin M. D. C., Markman E., Martin F., Martin A., Martin Dal Gesso C., Martinez F., Martinez-Fidalgo C., Martin-Loeches I., Mas A., Masaaki S., Maseda E., Massa E., Mattsson A., Maugeri J., McCredie V., McCullough J., McGuinness S., McKown A., Medve L., Mei C., Mellado Artigas R., Mendes V., Mervat M. K. E., Michaux I., Mikhaeil M., Milagros O., Milet I., Millan M. T., Minwei Z., Mirabella L., Mishra S., Mistraletti G., Mochizuki K., Moghal A., Mojoli F., Molin A., Montiel R., Montini L., Monza G., Mora Aznar M., Morakul S., Morales M., Moreno Torres D., Morocho Tutillo D. R., Motherway C., Mouhssine D., Mouloudi E., Munoz T., Munoz de Cabo C., Mustafa M., Muthuchellappan R., Muthukrishnan M., Muttini S., Nagata I., Nahar D., Nakanishi M., Nakayama I., Namendys-Silva S. A., Nanchal R., Nandakumar S., Nasi A., Nasir K., Navalesi P., Naz Aslam T., Nga Phan T., Nichol A., Niiyama S., Nikolakopoulou S., Nikolic E., Nitta K., Noc M., Nonas S., Nseir S., Nur Soyturk A., Obata Y., Oeckler R., Oguchi M., Ohshimo S., Oikonomou M., Ojados A., Oliveira M. T., Oliveira Filho W., Oliveri C., Olmos A., Omura K., Orlandi M. C., Orsenigo F., Ortiz-Ruiz De Gordoa L., Ota K., Ovalle Olmos R., Oveges N., Oziemski P., Ozkan Kuscu O., Pachas Alvarado F., Pagella G., Palaniswamy V., Palazon Sanchez E. L., Palmese S., Pan G., Pan W., Papanikolaou M., Papavasilopoulou T., Parekh A., Parke R., Parrilla F. J., Parrilla D., Pasha T., Pasin L., Patao L., Patel M., Patel G., Pati B. K., Patil J., Pattnaik S., Paul D., Pavesi M., Pavlotsky V. 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M., Regli A., Reina R., Resano Sarmiento N., Reynaud F., Rialp G., Ricart P., Rice T., Richardson A., Rieder M., Rinket M., Rios F., Risso Vazquez A., Riva I., Rivette M., Roca O., Roche-Campo F., Rodriguez C., Rodriguez G., Rodriguez Gonzalez D., Rodriguez Tucto X. Y., Rogers A., Romano M. E., Rortveit L., Rose A., Roux D., Rouze A., Rubatto Birri P. N., Ruilan W., Ruiz Robledo A., Ruiz-Aguilar A. L., Sadahiro T., Saez I., Sagardia J., Saha R., Saiphoklang N., Saito S., Salem M., Sales G., Salgado P., Samavedam S., Sami Mebazaa M., Samuelsson L., San Juan Roman N., Sanchez P., Sanchez-Ballesteros J., Sandoval Y., Sani E., Santos M., Santos C., Sanui M., Saravanabavan L., Sari S., Sarkany A., Sauneuf B., Savioli M., Sazak H., Scano R., Schneider F., Schortgen F., Schultz M. J., Schwarz G. 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W., Thomas M., Thungtitigul P., Thyrault M., Tilouch N., Timenetsky K., Tirapu J., Todeschini M., Tomas R., Tomaszewski C., Tonetti T., Tonnelier A., Trinder J., Trongtrakul K., Truwit J., Tsuei B., Tulaimat A., Turan S., Turkoglu M., Tyagi S., Ubeda A., Vagginelli F., Valenti M. F., Vallverdu I., Van Axel A., van den Hul I., van der Hoeven H., Van Der Meer N., Vanhoof M., Vargas-Ordonez M., Vaschetto R., Vascotto E., Vatsik M., Vaz A., Vazquez-Sanchez A., Ventura S., Vermeijden J. W., Vidal A., Vieira J., Vilela Costa Pinto B., Villagra A., Villegas Succar C., Vinorum O. G., Vitale G., Vj R., Vochin A., Voiriot G., Volta C. A., von Seth M., Wajdi M., Walsh D., Wang S., Wardi G., Ween-Velken N. 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C., Grasselli G., Laake J. H., Mancebo J., Penuelas O., Piquilloud L., Pesenti A., Wunsch H., van Haren F., Brochard L., Laffey J. G., Abrough F., Acharya S. P., Amin P., Arabi Y., Bauer P., Beitler J., Berkius J., Bugedo G., Camporota L., Cerny V., Cho Y. -J., Clarkson K., Estenssoro E., Goligher E., Gritsan A., Hashemian S. M., Hermans G., Heunks L. M., Jovanovic B., Kurahashi K., Matamis D., Moerer O., Molnar Z., Ozyilmaz E., Panka B., Papali A., Perbet S., Qiu H., Razek A. A., Rittayamai N., Roldan R., Serpa Neto A., Szuldrzynski K., Talmor D., Tomescu D., Villagomez A., Zeggwagh A. A., Abe T., Aboshady A., Acampo-de Jong M., Acharya S., Adderley J., Adiguzel N., Agrawal V. K., Aguilar G., Aguirre G., Aguirre-Bermeo H., Ahlstrom B., Akbas T., Akker M., Al Sadeh G., Alamri S., Algaba A., Ali M., Aliberti A., Allegue J. M., Alvarez D., Amador J., Andersen F. 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F., Fartoukh M., Fehrle L., Feng F., Feng Y., Fernandez I., Fernandez B., Fernandez-Rodriguez M. L., Ferrando C., Ferreira da Silva M. J., Ferreruela M., Ferrier J., Flamm Zamorano M. J., Flood L., Floris L., Fluckiger M., Forteza C., Fortunato A., Frans E., Frattari A., Fredes S., Frenzel T., Fumagalli R., Furche M. A., Fusari M., Fysh E., Galeas-Lopez J. L., Galerneau L. -M., Garcia A., Garcia M. F., Garcia E., Garcia Olivares P., Garlicki J., Garnero A., Garofalo E., Gautam P., Gazenkampf A., Gelinotte S., Gelormini D., Ghrenassia E., Giacomucci A., Giannoni R., Gigante A., Glober N., Gnesin P., Gollo Y., Gomaa D., Gomero Paredes R., Gomes R., Gomez R. A., Gomez O., Gomez A., Gondim L., Gonzalez M., Gonzalez I., Gonzalez-Castro A., Gordillo Romero O., Gordo F., Gouin P., Graf Santos J., Grainne R., Grando M., Granov Grabovica S., Grasso S., Grasso R., Grimmer L., Grissom C., Gu Q., Guan X. -D., Guarracino F., Guasch N., Guatteri L., Gueret R., Guerin C., Guerot E., Guitard P. -G., Gul F., Gumus A., Gurjar M., Gutierrez P., Hachimi A., Hadzibegovic A., Hagan S., Hammel C., Han Song J., Hanlon G., Heines S., Henriksson J., Herbrecht J. -E., Heredia Orbegoso G. O., Hermon A., Hernandez R., Hernandez C., Herrera L., Herrera-Gutierrez M., Hidalgo J., Hill D., Holmquist D., Homez M., Hongtao X., Hormis A., Horner D., Hornos M. C., Hou M., House S., Housni B., Hugill K., Humphreys S., Humbert L., Hunter S., Hwa Young L., Iezzi N., Ilutovich S., Inal V., Innes R., Ioannides P., Iotti G. A., Ippolito M., Irie H., Iriyama H., Itagaki T., Izura J., Izza S., Jabeen R., Jamaati H., Jamadarkhana S., Jamoussi A., Jankowski M., Jaramillo L. A., Jeon K., Jeong Lee S., Jeswani D., Jha S., Jiang L., Jing C., Jochmans S., Johnstad B. A., Jongmin L., Joret A., Junhasavasdikul D., Jurado M. T., Kam E., Kamohara H., Kane C., Kara I., Karakurt S., Karnjanarachata C., Kataoka J., Katayama S., Kaushik S., Kelebek Girgin N., Kerr K., Kerslake I., Khairnar P., Khalid A., Khan A., Khanna A. K., Khorasanee R., Kienhorst D., Kirakli C., Knafelj R., Kol M. K., Kongpolprom N., Kopitko C., Korkmaz Ekren P., Kubisz-Pudelko A., Kulcsar Z., Kumasawa J., Kuriyama A., Kutchak F., Labarca E., Labat F., Laborda C., Laca Barrera M. A., Lagache L., Landaverde Lopez A., Lanspa M., Lascari V., Le Meur M., Lee S. H., Lee Y. J., Lee J., Lee W. -Y., Legernaes T., Leiner T., Lemiale V., Leonor T., Lepper P. M., Li D., Li H., Li O., Lima A. R., Lind D., Litton E., Liu N., Liu L., Liu J., Llitjos J. -F., Llorente B., Lopez R., Lopez C. E., Lopez Nava C., Lovazzano P., Lu M., Lucchese F., Lugano M., Lugo Goytia G., Luo H., Lynch C., Macheda S., Madrigal Robles V. H., Maggiore S. M., Magret Iglesias M., Malaga P., Mallapura Maheswarappa H., Malpartida G., Malyarchikov A., Mansson H., Manzano A., Marey I., Marin N., Marin M. D. C., Markman E., Martin F., Martin A., Martin Dal Gesso C., Martinez F., Martinez-Fidalgo C., Martin-Loeches I., Mas A., Masaaki S., Maseda E., Massa E., Mattsson A., Maugeri J., McCredie V., McCullough J., McGuinness S., McKown A., Medve L., Mei C., Mellado Artigas R., Mendes V., Mervat M. K. E., Michaux I., Mikhaeil M., Milagros O., Milet I., Millan M. T., Minwei Z., Mirabella L., Mishra S., Mistraletti G., Mochizuki K., Moghal A., Mojoli F., Molin A., Montiel R., Montini L., Monza G., Mora Aznar M., Morakul S., Morales M., Moreno Torres D., Morocho Tutillo D. R., Motherway C., Mouhssine D., Mouloudi E., Munoz T., Munoz de Cabo C., Mustafa M., Muthuchellappan R., Muthukrishnan M., Muttini S., Nagata I., Nahar D., Nakanishi M., Nakayama I., Namendys-Silva S. A., Nanchal R., Nandakumar S., Nasi A., Nasir K., Navalesi P., Naz Aslam T., Nga Phan T., Nichol A., Niiyama S., Nikolakopoulou S., Nikolic E., Nitta K., Noc M., Nonas S., Nseir S., Nur Soyturk A., Obata Y., Oeckler R., Oguchi M., Ohshimo S., Oikonomou M., Ojados A., Oliveira M. T., Oliveira Filho W., Oliveri C., Olmos A., Omura K., Orlandi M. C., Orsenigo F., Ortiz-Ruiz De Gordoa L., Ota K., Ovalle Olmos R., Oveges N., Oziemski P., Ozkan Kuscu O., Pachas Alvarado F., Pagella G., Palaniswamy V., Palazon Sanchez E. L., Palmese S., Pan G., Pan W., Papanikolaou M., Papavasilopoulou T., Parekh A., Parke R., Parrilla F. J., Parrilla D., Pasha T., Pasin L., Patao L., Patel M., Patel G., Pati B. K., Patil J., Pattnaik S., Paul D., Pavesi M., Pavlotsky V. A., Paz G., Paz E., Pecci E., Pellegrini C., Pena Padilla A. G., Perchiazzi G., Pereira T., Pereira V., Perez M., Perez Calvo C., Perez Cheng M., Perez Maita R., Perez-Araos R., Perez-Teran P., Perez-Torres D., Perkins G., Persona P., Petnak T., Petrova M., Philippart F., Picetti E., Pierucci E., Piervincenzi E., Pinciroli R., Pintado M. -C., Piraino T., Piras S., Piras C., Pirompanich P., Pisani L., Platas E., Plotnikow G., Porras W., Porta V., Portilla M., Portugal J., Povoa P., Prat G., Pratto R., Preda G., Prieto I., Prol-Silva E., Pugh R., Qi Y., Qian C., Qin T., Qu H., Quintana T., Quispe Sierra R., Quispe Soto R., Rabbani R., Rabee M., Rabie A., Rahe Pereira M. A., Rai A., Raj Ashok S., Rajab M., Ramdhani N., Ramey E., Ranieri M., Rathod D., Ray B., Redwanul Huq S. M., Regli A., Reina R., Resano Sarmiento N., Reynaud F., Rialp G., Ricart P., Rice T., Richardson A., Rieder M., Rinket M., Rios F., Risso Vazquez A., Riva I., Rivette M., Roca O., Roche-Campo F., Rodriguez C., Rodriguez G., Rodriguez Gonzalez D., Rodriguez Tucto X. Y., Rogers A., Romano M. E., Rortveit L., Rose A., Roux D., Rouze A., Rubatto Birri P. N., Ruilan W., Ruiz Robledo A., Ruiz-Aguilar A. L., Sadahiro T., Saez I., Sagardia J., Saha R., Saiphoklang N., Saito S., Salem M., Sales G., Salgado P., Samavedam S., Sami Mebazaa M., Samuelsson L., San Juan Roman N., Sanchez P., Sanchez-Ballesteros J., Sandoval Y., Sani E., Santos M., Santos C., Sanui M., Saravanabavan L., Sari S., Sarkany A., Sauneuf B., Savioli M., Sazak H., Scano R., Schneider F., Schortgen F., Schultz M. J., Schwarz G. L., Seckin Yucesoy F., Seely A., Seiler F., Seker Tekdos Y., Seok Chan K., Serano L., Serednicki W., Setten M., Shah A., Shah B., Shang Y., Shanmugasundaram P., Shapovalov K., Shebl E., Shiga T., Shime N., Shin P., Short J., Shuhua C., Siddiqui S., Silesky Jimenez J. I., Silva D., Silva Sales B., Simons K., Sjobo B. A., Slessor D., Smiechowicz J., Smischney N., Smith P., Smith T., Smith M., Snape S., Snyman L., Soetens F., Sook Hong K., Sosa Medellin M. A., Soto G., Souloy X., Sousa E., Sovatzis S., Sozutek D., Spadaro S., Spagnoli M., Spangfors M., Spittle N., Spivey M., Stapleton A., Stefanovic B., Stephenson L., Stevenson E., Strand K., Strano M. T., Straus S., Sun C., Sun R., Sundaram V., SunPark T., Surlemont E., Sutherasan Y., Szabo Z., Tainter C., Takaba A., Tallott M., Tamasato T., Tang Z., Tangsujaritvijit V., Taniguchi L., Taniguchi D., Tarantino F., Teerapuncharoen K., Temprano S., Terragni P., Terzi N., Thakur A., Theerawit P., Thille A. W., Thomas M., Thungtitigul P., Thyrault M., Tilouch N., Timenetsky K., Tirapu J., Todeschini M., Tomas R., Tomaszewski C., Tonetti T., Tonnelier A., Trinder J., Trongtrakul K., Truwit J., Tsuei B., Tulaimat A., Turan S., Turkoglu M., Tyagi S., Ubeda A., Vagginelli F., Valenti M. F., Vallverdu I., Van Axel A., van den Hul I., van der Hoeven H., Van Der Meer N., Vanhoof M., Vargas-Ordonez M., Vaschetto R., Vascotto E., Vatsik M., Vaz A., Vazquez-Sanchez A., Ventura S., Vermeijden J. W., Vidal A., Vieira J., Vilela Costa Pinto B., Villagra A., Villegas Succar C., Vinorum O. G., Vitale G., Vj R., Vochin A., Voiriot G., Volta C. A., von Seth M., Wajdi M., Walsh D., Wang S., Wardi G., Ween-Velken N. C., Wei B. -L., Weller D., Welsh D., Welters I., Wert M., Whiteley S., Wilby E., Williams E., Williams K., Wilson A., Wojtas J., Won Huh J., Wrathall D., Wright C., Wu J. -F., Xi G., Xing Z. -J., Xu H., Yamamoto K., Yan J., Yanez J., Yang X., Yates E., Yazicioglu Mocin O., Ye Z., Yildirim F., Yoshida N., Yoshido H. H. L., Young Lee B., Yu R., Yu G., Yu T., Yuan B., Yuangtrakul N., Yumoto T., Yun X., Zakalik G., Zaki A., Zalba-Etayo B., Zambon M., Zang B., Zani G., Zarka J., Zerbi S. M., Zerman A., Zetterquist H., Zhang J., Zhang H., Zhang W., Zhang G., Zhao H., Zheng J., Zhu B., and Zumaran R.
- Abstract
Background: Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation. Methods: WEAN SAFE was an international, multicentre, prospective, observational cohort study done in 481 intensive care units in 50 countries. Eligible participants were older than 16 years, admitted to a participating intensive care unit, and receiving mechanical ventilation for 2 calendar days or longer. We defined weaning initiation as the first attempt to separate a patient from the ventilator, successful weaning as no reintubation or death within 7 days of extubation, and weaning eligibility criteria based on positive end-expiratory pressure, fractional concentration of oxygen in inspired air, and vasopressors. The primary outcome was the proportion of patients successfully weaned at 90 days. Key secondary outcomes included weaning duration, timing of weaning events, factors associated with weaning delay and weaning failure, and hospital outcomes. This study is registered with ClinicalTrials.gov, NCT03255109. Findings: Between Oct 4, 2017, and June 25, 2018, 10 232 patients were screened for eligibility, of whom 5869 were enrolled. 4523 (77·1%) patients underwent at least one separation attempt and 3817 (65·0%) patients were successfully weaned from ventilation at day 90. 237 (4·0%) patients were transferred before any separation attempt, 153 (2·6%) were transferred after at least one separation attempt and not successfully weaned, and 1662 (28·3%) died while invasively ventilated. The median time from fulfilling weaning eligibility criteria to first separation attempt was 1 day (IQR 0–4), and 1013 (22·4%) patients had a delay in initiating first separation of 5 or more days. Of the 4523 (77·1%) patients with separation attempts, 2927 (64·7%) had a short wean (≤1 d
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- 2023
3. Active study: undetected prevalence and clinical inertia in the treatment of breakthrough cancer pain (BTcP)
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Camps Herrero, C., Reina Zoilo, J. J., Monge Martín, D., Caballero Martínez, F., Guillem Porta, V., Aranda Aguilar, E., Carrato Mena, A., Díaz-Rubio García, E., García-Foncillas López, J., Feijóo Saus, M., and López López, R.
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- 2019
- Full Text
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4. Oncologist’s knowledge and implementation of guidelines for breakthrough cancer pain in Spain: CONOCE study
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López López, R., Camps Herrero, C., Khosravi-Shahi, P., Guillem Porta, V., Carrato Mena, A., Garcia-Foncillas, J., Cruz Hernández, J. J., Gascón Vilaplana, P., Antón Torres, A., Diaz-Rubio, E., Feyjoo Saus, M., and Aranda Aguilar, E.
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- 2018
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5. Evolution of host-plant associations and biogeographic patterns on a global scale within the oak gall wasps
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Nicholls, J., Reiss, A, Abe, Y., Csoka, G., Cuesta-Porta, V., DeMartini, J., Scott, C., Ito, M., Medianero, E., Melika, G., Nieves-Aldrey, J. L., Price, P., Schick, K., Schönrogge, K., Sinclair, F., Tang, Chang-Ti., Man-Miao, Y., Stone, G.N, Nicholls, J., Reiss, A, Abe, Y., Csoka, G., Cuesta-Porta, V., DeMartini, J., Scott, C., Ito, M., Medianero, E., Melika, G., Nieves-Aldrey, J. L., Price, P., Schick, K., Schönrogge, K., Sinclair, F., Tang, Chang-Ti., Man-Miao, Y., and Stone, G.N
- Abstract
Co-evolutionary interactions between insect herbivores and their host plants underlie much contemporary biodiversity and are vital to assembly of natural ecosystems. Assemblages of galls on oaks induced by Cynipini wasps (Hymenoptera: Cynipidae) occur across much of the Northern Hemisphere, their diversity peaking in the Nearctic and on white oaks (Quercus section Quercus). However, the evolutionary history of the clade has been debated with respect to geographic origins, direction and timings of dispersal events, and shifts in host plant associations. We examined these questions using a global-scale, 6-gene phylogeny of 430 Cynipini species and a dataset of their associated host plants encompassing all eight sections within Quercus plus five Fagaceae genera. Likelihood-based ancestral state reconstructions demonstrate a Nearctic origin of the Cynipini followed by repeated colonisations of the Palearctic via both westwards and eastwards dispersal. These inferences are robust to bias in taxon sampling across continents and the inclusion of Protobalandricus as the sister lineage to Cynipini sensu stricto. Likewise, the association with white oaks is probably ancestral and has been retained by many Cynipini lineages. However, host shifts to other sections within Quercus and related Fagaceae genera are widely distributed across the cynipid phylogeny. They are associated with both global-scale range shifts and within-bioregion exploitation of alternative hosts, and their frequency typically correlates with host-plant relatedness. These findings highlight the evolutionary success of cynipids on white oak hosts and the connectedness of continental assemblages of gall wasps over evolutionary time.
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- 2023
6. Recent advances in the genus- and species level molecular systematics of the Cynipini
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Nicholls, J., Melika, G., Cuesta-Porta, V., Scott, C., Medianero, E., Nieves-Aldrey, J.L., Pujade-Villar, J., Tang, Chang-Ti., Stone, G.N., Nicholls, J., Melika, G., Cuesta-Porta, V., Scott, C., Medianero, E., Nieves-Aldrey, J.L., Pujade-Villar, J., Tang, Chang-Ti., and Stone, G.N.
- Abstract
The taxonomy of oak gallwasps (Hymenoptera: Cynipidae: Cynipini) has a long and sometimes confusing history. Many large genera have become hold-alls for a diversity of lineages, and are often delimited by combinations of pleisiomorphic character states. At species level, the presence of alternating generations further complicates Cynipini taxonomy. With the increased use of molecular systematics, it is clear that current Cynipini taxonomy is inadequate and requires major revisions. Here we provide an overview of recent work helping to resolve the chaotic mess of Cynipini taxonomy. Some of this work has involved purely morphological re-assessment of particularly distinctive lineages, while much is based upon ongoing systematic work using a 6-gene molecular phylogeny containing 430 species representing all the known major lineages/genera within the Cynipini. Incorporation of phylogenetic information has revealed that all of the large, Holarctic-distributed genera are polyphyletic. In addition, the limits of many smaller genera require redefining, and widespread sampling indicates that many of these genera may be represented by a larger complement of species across a broader geographic area. Molecular data also provide a quick and simple method for matching alternate generations of Cynipini species. Development of collection genomics workflows has opened up biological collections to molecular analysis, potentially providing DNA sequence data for matching generations. Within Cynipini, this could allow for the sizeable series of specimens collected by early researchers such as Kinsey and Weld to be used for clarifying the species-level taxonomy of large numbers of Cynipini taxa.
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- 2023
7. Towards Machine Learning Enabled Analysis of Urban Mobility of Electric Motorbike: A Case Study for Improving Road Manteinance and Driver’s Safety in La Coruna City
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Branco D., Di Martino B., Venticinque S., Fernandez A. L., Porta V., Barolli, L., Branco, D., Di Martino, B., Venticinque, S., Fernandez, A. L., and Porta, V.
- Abstract
Data availability from real applications is not a concern anymore, nevertheless the extraction of necessary information is still the challenge. Identifying the areas that contain the highest number of crashes within a city may be of particular interest for urban mobility and risk prevention. Also, having areas of the city classified according to the risk of crashes (areas with high presence of road bumps, uneven road surfaces, etc.) would allow companies to apply targeted business policies, to minimize maintenance costs and the deterioration of electric motorbikes. In this work, artificial intelligence algorithms and time series geographical clustering techniques are investigated in order to classify the risk areas of the city of La Coruna in Spain.
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- 2022
8. Communication and visiting policies in Italian intensive care units during the first COVID-19 pandemic wave and lockdown: a nationwide survey
- Author
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Langer, T, Depalo, F, Forlini, C, Landini, S, Mezzetti, A, Previtali, P, Monti, G, de Toma, C, Biscardi, D, Giannini, A, Fumagalli, R, Mistraletti, G, Lissoni, B, De Martini, A, Mareto, N, Rossitto, C, Zummo, U, Taverna, M, Machieraldo, P, Navarra, M, Parlanti Garbero, M, Scaletti, C, Perno, S, Amendolia, L, Montrucchio, G, Veliaj, D, Barbarello, G, Alesci, M, Bolgiaghi, L, Vailati, D, Pezzi, A, Boselli, E, Piccoli, F, Greco, M, Gemma, M, Resta, M, Crotti, S, Bottino, N, Abruzzese, C, Savioli, M, Migliorino, G, Muttini, S, Umbrello, M, Borghi, B, Greco, S, Dizeo, M, Bottiroli, M, Mondino, M, Prosepri, M, Casella, G, Curto, F, Zaniboni, M, Giudici, R, Gentile, C, Bombino, M, Rona, R, Cortinovis, B, Benini, A, Avalli, L, Tavola, M, Ferrario, M, Preda, R, Primerano, E, Russo, G, Porta, V, Valdambrini, F, Fassini, P, Orando, S, Beck, E, Pedeferri, M, Cogliati, G, Testini, D, Moroni, B, Codeluppi, V, Ruggeri, P, Milanesi, E, Belliato, M, Besozzi, A, Riccio, M, Zerbi, S, Corbella, D, Ferri, F, Grazioli, L, Bonanomi, E, Giacomini, M, Sacchi, N, Codognola, C, Ambrosini, A, Guatteri, L, Subert, M, Castelli, G, Borelli, M, Venier, E, Dittura, L, Buttera, S, Bigai, R, Magnoni, S, Rauch, S, Colombo, A, Fullin, G, Donolato, C, Cattin, S, State, V, Redeghieri, E, Russo, A, Pastorini, S, Allena, S, Munari, M, Turchet, F, Peta, M, De Santis, V, Scala, C, Facondini, F, Marangoni, E, Tassinati, T, Zanzani, C, Russo, E, Marchio, A, Barbagallo, M, Girardis, M, Taffache, P, Mordacci, M, Vincenzi, M, Pennica, M, Bracciotti, G, Iori, P, Gambi, D, Cappellini, I, Vegnuti, L, De Luca, A, Romagnoli, S, Mosti, G, Carla, R, Roticiani, V, Pelagalli, L, Fuselli, E, D’Avino, E, De Bellis, M, Gianni, G, Leonardis, F, Rossi, M, Lorusso, R, Magnanimi, E, Martelli, S, Baisi, F, Balsamo, D, Cotticelli, V, Mattei, A, Farinelli, I, Riccini, T, Cola, L, Jorio, A, Iacobone, E, Domizi, R, Pizzi, S, Nasso, A, Graziani, R, Monaco, A, Manno, M, Ottelio, C, Del Rio, M, Serra, A, Enna, B, Loddo, F, Galbiati, R, Mellea, S, Kimberly, M, Vissani, M, Romito, F, Baccari, L, Zarrillo, N, Esposito, C, Murino, P, Notaro, S, Ausiello, C, Marra, A, Policastro, C, Cafora, C, De Benedectis, G, Di Falco, V, Sciddurlo, M, Negro, G, Vetuschi, P, Recchia, A, Pasquariello, R, Squillace, R, Ciambrone, A, Bencivenga, C, Camiolo, M, Agozzino, C, Oliveri, F, Notarrigo, T, Castiglione, G, Mo, A, Condorelli, L, Favarato, M, Langer, Thomas, Depalo, Francesca Carmela, Forlini, Clarissa, Landini, Silvia, Mezzetti, Andrea, Previtali, Paola, Monti, Gianpaola, de Toma, Carolina, Biscardi, Davide, Giannini, Alberto, Fumagalli, Roberto, Mistraletti, Giovanni, Lissoni, Barbara, De Martini, Andrea, Mareto, Nadia, Rossitto, Concetta, Zummo, Ugo, Taverna, Martina, Machieraldo, Patrizia, Navarra, Mauro, Parlanti Garbero, Massimiliano, Scaletti, Chiara, Perno, Silvia, Amendolia, Luca, Montrucchio, Giuseppe, Veliaj, Deliana, Barbarello, Giuseppe, Alesci, Maria, Bolgiaghi, Luca, Vailati, Davide, Pezzi, Angelo, Boselli, Enrico, Piccoli, Francesca, Greco, Massimiliano, Gemma, Marco, Resta, Marco, Crotti, Stefania, Bottino, Nicola, Abruzzese, Chiara, Savioli, Monica, Migliorino, Giuseppina, Muttini, Stefano, Umbrello, Michele, Borghi, Beatrice, Greco, Stefano, Dizeo, Micaela, Bottiroli, Maurizio, Mondino, Michele Giovanni, Prosepri, Manlio, Casella, Giampaolo, Curto, Francesco, Zaniboni, Matteo, Giudici, Riccardo, Gentile, Carlo, Bombino, Michela, Rona, Roberto, Cortinovis, Barbara, Benini, Annalisa, Avalli, Leonello, Tavola, Mario, Ferrario, Matteo, Preda, Roberta, Primerano, Enzo, Russo, Gianluca, Porta, Virginia, Valdambrini, Federico, Fassini, Paola, Orando, Serena, Beck, Eduardo, Pedeferri, Matteo, Cogliati, Giacomina, Testini, Denise, Moroni, Benedetta, Codeluppi, Vito, Ruggeri, Patrizia, Milanesi, Elisa, Belliato, Mirko, Besozzi, Alessandra, Riccio, Mario, Zerbi, Silvia, Corbella, Davide, Ferri, Francesco, Grazioli, Lorenzo, Bonanomi, Ezio, Giacomini, Matteo, Sacchi, Noemi, Codognola, Cristian, Ambrosini, Alessandra, Guatteri, Luca, Subert, Matteo, Castelli, Gian Paolo, Borelli, Massimo, Venier, Erica, Dittura, Loredana, Buttera, Stefania, Bigai, Roberto, Magnoni, Sandra, Rauch, Simon, Colombo, Angelo, Fullin, Giorgio, Donolato, Caterina, Cattin, Silvia, State, Veronica, Redeghieri, Enrico, Russo, Alessandro, Pastorini, Simonetta, Allena, Sandra, Munari, Marina, Turchet, Federica, Peta, Mario, De Santis, Vincenzo, Scala, Cristina, Facondini, Francesca, Marangoni, Elisabetta, Tassinati, Tania, Zanzani, Chiara, Russo, Emanuele, Marchio, Annamaria, Barbagallo, Maria, Girardis, Massimo, Taffache, Paolo, Mordacci, Marco, Vincenzi, Matteo, Pennica, Michele, Bracciotti, Giovanna, Iori, Paola, Gambi, Davide, Cappellini, Iacopo, Vegnuti, Lara, De Luca, Alessandra, Romagnoli, Stefano, Mosti, Giamila, Carla, Rossella, Roticiani, Valeria, Pelagalli, Lorella, Fuselli, Ennio, D’Avino, Emilio, De Bellis, Massimo, Gianni, Giulia, Leonardis, Francesca, Rossi, Marzia, Lorusso, Rossana, Magnanimi, Eugenia, Martelli, Sabrina, Baisi, Floriana, Balsamo, Davide, Cotticelli, Virginia, Mattei, Alessia, Farinelli, Ivano, Riccini, Teresa, Cola, Luisanna, Jorio, Antonella, Iacobone, Emanuele, Domizi, Roberta, Pizzi, Simone, Nasso, Armando, Graziani, Romano, Monaco, Anna, Manno, Manuela, Ottelio, Carla Maria, Del Rio, Michela, Serra, Antonio, Enna, Barbara, Loddo, Francesco Marco, Galbiati, Rita, Mellea, Serena, Kimberly, Michelle Brozzi, Vissani, Matteo, Romito, Francesco Massimo, Baccari, Laura, Zarrillo, Nadia, Esposito, Clelia, Murino, Patrizia, Notaro, Salvatore, Ausiello, Carmine, Marra, Annachiara, Policastro, Carmela, Cafora, Chiara, De Benedectis, Giuseppe, Di Falco, Vincenzo, Sciddurlo, Maria, Negro, Giancarlo, Vetuschi, Paolo, Recchia, Andrea, Pasquariello, Rita, Squillace, Rosalba, Ciambrone, Antonio, Bencivenga, Carmela, Camiolo, Melania, Agozzino, Cristina, Oliveri, Francesco, Notarrigo, Tiziana, Castiglione, Giacomo, Mo, Antonella, Condorelli, Laura, Favarato, Martina, Langer, T, Depalo, F, Forlini, C, Landini, S, Mezzetti, A, Previtali, P, Monti, G, de Toma, C, Biscardi, D, Giannini, A, Fumagalli, R, Mistraletti, G, Lissoni, B, De Martini, A, Mareto, N, Rossitto, C, Zummo, U, Taverna, M, Machieraldo, P, Navarra, M, Parlanti Garbero, M, Scaletti, C, Perno, S, Amendolia, L, Montrucchio, G, Veliaj, D, Barbarello, G, Alesci, M, Bolgiaghi, L, Vailati, D, Pezzi, A, Boselli, E, Piccoli, F, Greco, M, Gemma, M, Resta, M, Crotti, S, Bottino, N, Abruzzese, C, Savioli, M, Migliorino, G, Muttini, S, Umbrello, M, Borghi, B, Greco, S, Dizeo, M, Bottiroli, M, Mondino, M, Prosepri, M, Casella, G, Curto, F, Zaniboni, M, Giudici, R, Gentile, C, Bombino, M, Rona, R, Cortinovis, B, Benini, A, Avalli, L, Tavola, M, Ferrario, M, Preda, R, Primerano, E, Russo, G, Porta, V, Valdambrini, F, Fassini, P, Orando, S, Beck, E, Pedeferri, M, Cogliati, G, Testini, D, Moroni, B, Codeluppi, V, Ruggeri, P, Milanesi, E, Belliato, M, Besozzi, A, Riccio, M, Zerbi, S, Corbella, D, Ferri, F, Grazioli, L, Bonanomi, E, Giacomini, M, Sacchi, N, Codognola, C, Ambrosini, A, Guatteri, L, Subert, M, Castelli, G, Borelli, M, Venier, E, Dittura, L, Buttera, S, Bigai, R, Magnoni, S, Rauch, S, Colombo, A, Fullin, G, Donolato, C, Cattin, S, State, V, Redeghieri, E, Russo, A, Pastorini, S, Allena, S, Munari, M, Turchet, F, Peta, M, De Santis, V, Scala, C, Facondini, F, Marangoni, E, Tassinati, T, Zanzani, C, Russo, E, Marchio, A, Barbagallo, M, Girardis, M, Taffache, P, Mordacci, M, Vincenzi, M, Pennica, M, Bracciotti, G, Iori, P, Gambi, D, Cappellini, I, Vegnuti, L, De Luca, A, Romagnoli, S, Mosti, G, Carla, R, Roticiani, V, Pelagalli, L, Fuselli, E, D’Avino, E, De Bellis, M, Gianni, G, Leonardis, F, Rossi, M, Lorusso, R, Magnanimi, E, Martelli, S, Baisi, F, Balsamo, D, Cotticelli, V, Mattei, A, Farinelli, I, Riccini, T, Cola, L, Jorio, A, Iacobone, E, Domizi, R, Pizzi, S, Nasso, A, Graziani, R, Monaco, A, Manno, M, Ottelio, C, Del Rio, M, Serra, A, Enna, B, Loddo, F, Galbiati, R, Mellea, S, Kimberly, M, Vissani, M, Romito, F, Baccari, L, Zarrillo, N, Esposito, C, Murino, P, Notaro, S, Ausiello, C, Marra, A, Policastro, C, Cafora, C, De Benedectis, G, Di Falco, V, Sciddurlo, M, Negro, G, Vetuschi, P, Recchia, A, Pasquariello, R, Squillace, R, Ciambrone, A, Bencivenga, C, Camiolo, M, Agozzino, C, Oliveri, F, Notarrigo, T, Castiglione, G, Mo, A, Condorelli, L, Favarato, M, Langer, Thomas, Depalo, Francesca Carmela, Forlini, Clarissa, Landini, Silvia, Mezzetti, Andrea, Previtali, Paola, Monti, Gianpaola, de Toma, Carolina, Biscardi, Davide, Giannini, Alberto, Fumagalli, Roberto, Mistraletti, Giovanni, Lissoni, Barbara, De Martini, Andrea, Mareto, Nadia, Rossitto, Concetta, Zummo, Ugo, Taverna, Martina, Machieraldo, Patrizia, Navarra, Mauro, Parlanti Garbero, Massimiliano, Scaletti, Chiara, Perno, Silvia, Amendolia, Luca, Montrucchio, Giuseppe, Veliaj, Deliana, Barbarello, Giuseppe, Alesci, Maria, Bolgiaghi, Luca, Vailati, Davide, Pezzi, Angelo, Boselli, Enrico, Piccoli, Francesca, Greco, Massimiliano, Gemma, Marco, Resta, Marco, Crotti, Stefania, Bottino, Nicola, Abruzzese, Chiara, Savioli, Monica, Migliorino, Giuseppina, Muttini, Stefano, Umbrello, Michele, Borghi, Beatrice, Greco, Stefano, Dizeo, Micaela, Bottiroli, Maurizio, Mondino, Michele Giovanni, Prosepri, Manlio, Casella, Giampaolo, Curto, Francesco, Zaniboni, Matteo, Giudici, Riccardo, Gentile, Carlo, Bombino, Michela, Rona, Roberto, Cortinovis, Barbara, Benini, Annalisa, Avalli, Leonello, Tavola, Mario, Ferrario, Matteo, Preda, Roberta, Primerano, Enzo, Russo, Gianluca, Porta, Virginia, Valdambrini, Federico, Fassini, Paola, Orando, Serena, Beck, Eduardo, Pedeferri, Matteo, Cogliati, Giacomina, Testini, Denise, Moroni, Benedetta, Codeluppi, Vito, Ruggeri, Patrizia, Milanesi, Elisa, Belliato, Mirko, Besozzi, Alessandra, Riccio, Mario, Zerbi, Silvia, Corbella, Davide, Ferri, Francesco, Grazioli, Lorenzo, Bonanomi, Ezio, Giacomini, Matteo, Sacchi, Noemi, Codognola, Cristian, Ambrosini, Alessandra, Guatteri, Luca, Subert, Matteo, Castelli, Gian Paolo, Borelli, Massimo, Venier, Erica, Dittura, Loredana, Buttera, Stefania, Bigai, Roberto, Magnoni, Sandra, Rauch, Simon, Colombo, Angelo, Fullin, Giorgio, Donolato, Caterina, Cattin, Silvia, State, Veronica, Redeghieri, Enrico, Russo, Alessandro, Pastorini, Simonetta, Allena, Sandra, Munari, Marina, Turchet, Federica, Peta, Mario, De Santis, Vincenzo, Scala, Cristina, Facondini, Francesca, Marangoni, Elisabetta, Tassinati, Tania, Zanzani, Chiara, Russo, Emanuele, Marchio, Annamaria, Barbagallo, Maria, Girardis, Massimo, Taffache, Paolo, Mordacci, Marco, Vincenzi, Matteo, Pennica, Michele, Bracciotti, Giovanna, Iori, Paola, Gambi, Davide, Cappellini, Iacopo, Vegnuti, Lara, De Luca, Alessandra, Romagnoli, Stefano, Mosti, Giamila, Carla, Rossella, Roticiani, Valeria, Pelagalli, Lorella, Fuselli, Ennio, D’Avino, Emilio, De Bellis, Massimo, Gianni, Giulia, Leonardis, Francesca, Rossi, Marzia, Lorusso, Rossana, Magnanimi, Eugenia, Martelli, Sabrina, Baisi, Floriana, Balsamo, Davide, Cotticelli, Virginia, Mattei, Alessia, Farinelli, Ivano, Riccini, Teresa, Cola, Luisanna, Jorio, Antonella, Iacobone, Emanuele, Domizi, Roberta, Pizzi, Simone, Nasso, Armando, Graziani, Romano, Monaco, Anna, Manno, Manuela, Ottelio, Carla Maria, Del Rio, Michela, Serra, Antonio, Enna, Barbara, Loddo, Francesco Marco, Galbiati, Rita, Mellea, Serena, Kimberly, Michelle Brozzi, Vissani, Matteo, Romito, Francesco Massimo, Baccari, Laura, Zarrillo, Nadia, Esposito, Clelia, Murino, Patrizia, Notaro, Salvatore, Ausiello, Carmine, Marra, Annachiara, Policastro, Carmela, Cafora, Chiara, De Benedectis, Giuseppe, Di Falco, Vincenzo, Sciddurlo, Maria, Negro, Giancarlo, Vetuschi, Paolo, Recchia, Andrea, Pasquariello, Rita, Squillace, Rosalba, Ciambrone, Antonio, Bencivenga, Carmela, Camiolo, Melania, Agozzino, Cristina, Oliveri, Francesco, Notarrigo, Tiziana, Castiglione, Giacomo, Mo, Antonella, Condorelli, Laura, and Favarato, Martina
- Abstract
Background: During the first coronavirus disease 2019 (COVID-19) pandemic wave, an unprecedented number of patients with respiratory failure due to a new, highly contagious virus needed hospitalization and intensive care unit (ICU) admission. The aim of the present study was to describe the communication and visiting policies of Italian intensive care units (ICUs) during the first COVID-19 pandemic wave and national lockdown and compare these data with prepandemic conditions. Methods: A national web-based survey was conducted among 290 Italian hospitals. Each ICU (active between February 24 and May 31, 2020) was encouraged to complete an individual questionnaire inquiring the hospital/ICU structure/organization, communication/visiting habits and the role of clinical psychology prior to, and during the first COVID-19 pandemic wave. Results: Two hundred and nine ICUs from 154 hospitals (53% of the contacted hospitals) completed the survey (202 adult and 7 pediatric ICUs). Among adult ICUs, 60% were dedicated to COVID-19 patients, 21% were dedicated to patients without COVID-19 and 19% were dedicated to both categories (Mixed). A total of 11,102 adult patients were admitted to the participating ICUs during the study period and only approximately 6% of patients received at least one visit. Communication with family members was guaranteed daily through an increased use of electronic devices and was preferentially addressed to the same family member. Compared to the prepandemic period, clinical psychologists supported physicians more often regarding communication with family members. Fewer patients received at least one visit from family members in COVID and mixed-ICUs than in non-COVID ICUs, l (0 [0-6]%, 0 [0-4]% and 11 [2-25]%, respectively, p < 0.001). Habits of pediatric ICUs were less affected by the pandemic. Conclusions: Visiting policies of Italian ICUs dedicated to adult patients were markedly altered during the first COVID-19 wave. Remote communication was wi
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- 2022
9. The Economic Burden of Localized Prostate Cancer and Insights Derived from Cost-Effectiveness Studies of the Different Treatments
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Cantarero-Prieto D, Lera J, Lanza-Leon P, Barreda-Gutierrez M, Guillem-Porta V, Castelo-Branco L, and Martin-Moreno J
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localized prostate cancer ,economic burden ,cost of illness ,cost-effectiveness analysis - Abstract
Simple Summary Prostate cancer is one of the most frequent and impacting malignant neoplasms for men. In particular, localized prostate cancer has a notably high incidence and prevalence, despite which a solid consensus on treatment and procedure of care has not yet been reached. This article aims to shed light on this challenge by characterizing the economic burden and cost-effectiveness of different treatment strategies for localized prostate cancer after analyzing published comparable data from studies conducted in OECD countries. Prostate cancer has huge health and societal impacts, and there is no clear consensus on the most effective and efficient treatment strategy for this disease, particularly for localized prostate cancer. We have reviewed the scientific literature describing the economic burden and cost-effectiveness of different treatment strategies for localized prostate cancer in OECD countries. We initially identified 315 articles, studying 13 of them in depth (those that met the inclusion criteria), comparing the social perspectives of cost, time period, geographical area, and severity. The economic burden arising from prostate cancer due to losses in productivity and increased caregiver load is noticeable, but clinical decision-making is carried out with more subjective variability than would be advisable. The direct cost of the intervention was the main driver for the treatment of less severe cases of prostate cancer, whereas for more severe cases, the most important determinant was the loss in productivity. Newer, more affordable radiotherapy strategies may play a crucial role in the future treatment of early prostate cancer. The interpretation of our results depends on conducting thorough sensitivity analyses. This approach may help better understand parameter uncertainty and the methodological choices discussed in health economics studies. Future results of ongoing clinical trials that are considering genetic characteristics in assessing treatment response of patients with localized prostate cancer may shed new light on important clinical and pharmacoeconomic decisions.
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- 2022
10. Social value of a quality-adjusted life year (QALY) in Spain: the point of view of oncologists
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Camps-Herrero, C., Paz-Ares, L., Codes, M., López-López, R., Antón-Torres, A., Gascón-Vilaplana, P., Guillem-Porta, V., Carrato, A., Cruz-Hernández, J. J., Caballero-Díaz, C., Blasco-Cordellat, A., Moreno-Nogueira, J. A., and Díaz-Rubio, E.
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- 2014
- Full Text
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11. Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS
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Piotti, A., Novelli, D., Meessen, J. M. T. A., Ferlicca, D., Coppolecchia, S., Marino, A., Salati, G., Savioli, M., Grasselli, G., Bellani, G., Pesenti, A., Masson, S., Caironi, P., Gattinoni, L., Gobbi, M., Fracasso, C., Latini, R., Bruzzone, P., Pagan, F., Russo, R., Confalonieri, A., Abbruzzese, C., Vergnano, B., Faenza, S., Siniscalchi, A., Pierucci, E., Noto, A., Pezzi, A., Spanu, P., Parrini, V., Oggioni, R., Pasetti, G. S., Casadio, M. C., Buontempo, R., Carrer, S., Piccoli, F., Rizzi, T., Caricato, A., La Sala, M., Antonaci, A., Fassini, P., Paganini, S., Porta, V., Moise, G., Marell, S., Furia, M., Urbano, M. C., Carobbi, R., Poleni, S., Kandil, H., Ballotta, A., Bettini, F., Sanseverino, M., Gatta, A., Cecchini, F., Guatteri, L., Ciceri, G., Raimondi, F., Colombo, R., Ferraris, S., Borelli, M., Bellato, V., Cancellieri, F., Senni, S., Bertocchi, E., Ferri, P., Moioli, G., Fedele, A., Molin, A., Salsi, P., Brunori, E., Elisei, D., Maggio, G., Nicola, F. G., Cavana, M., Morelli, G., Guarino, A., Isetta, M., Tulli, G., Mangani, V., Rossi, N., Ferrari, M., Bona, F., Vay, M., Bartoli, T., Gallo, M., Vettoretto, K., Morte, M. D., Boselli, E., Puscio, D., Bovo, M., Galzerano, A., Carli, M., Zagara, G., Piotti, A, Novelli, D, Meessen, J, Ferlicca, D, Coppolecchia, S, Marino, A, Salati, G, Savioli, M, Grasselli, G, Bellani, G, Pesenti, A, Masson, S, Caironi, P, Gattinoni, L, Gobbi, M, Fracasso, C, and Latini, R
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Male ,Letter ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Critical Care and Intensive Care Medicine ,Gastroenterology ,0302 clinical medicine ,VE-cadherin ,Sphingosine ,Septic shock ,80 and over ,Medicine ,Endothelial dysfunction ,Phosphorylation ,Aged, 80 and over ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,Shock ,Biomarker ,Glycocalyx ,Sphingosine-1-phosphate ,Syndecan-1 ,Aged ,Antigens, CD ,Biomarkers ,Cadherins ,Endothelium ,Female ,Humans ,Italy ,Lysophospholipids ,Middle Aged ,Retrospective Studies ,Shock, Septic ,Extravasation ,3. Good health ,CD ,Endothelial stem cell ,medicine.medical_specialty ,Sepsis ,03 medical and health sciences ,Internal medicine ,Albumins ,Settore MED/41 - ANESTESIOLOGIA ,Renal replacement therapy ,Antigens ,business.industry ,Septic ,Research ,Albumin ,030208 emergency & critical care medicine ,lcsh:RC86-88.9 ,medicine.disease ,business - Abstract
Background Septic shock is characterized by breakdown of the endothelial glycocalyx and endothelial damage, contributing to fluid extravasation, organ failure and death. Albumin has shown benefit in septic shock patients. Our aims were: (1) to identify the relations between circulating levels of syndecan-1 (SYN-1), sphingosine-1-phosphate (S1P) (endothelial glycocalyx), and VE-cadherin (endothelial cell junctions), severity of the disease, and survival; (2) to evaluate the effects of albumin supplementation on endothelial dysfunction in patients with septic shock. Methods This was a retrospective analysis of a multicenter randomized clinical trial on albumin replacement in severe sepsis or septic shock (the Albumin Italian Outcome Sepsis Trial, ALBIOS). Concentrations of SYN-1, S1P, soluble VE-cadherin and other biomarkers were measured on days 1, 2 and 7 in 375 patients with septic shock surviving up to 7 days after randomization. Results Plasma concentrations of SYN-1 and VE-cadherin rose significantly over 7 days. SYN-1 and VE-cadherin were elevated in patients with organ failure, and S1P levels were lower. SYN-1 and VE-cadherin were independently associated with renal replacement therapy requirement during ICU stay, but only SYN-1 predicted its new occurrence. Both SYN-1 and S1P, but not VE-cadherin, predicted incident coagulation failure. Only SYN-1 independently predicted 90-day mortality. Albumin significantly reduced VE-cadherin, by 9.5% (p = 0.003) at all three time points. Conclusion Circulating components of the endothelial glycocalyx and of the endothelial cell junctions provide insights into severity and progression of septic shock, with special focus on incident coagulation and renal failure. Albumin supplementation lowered circulating VE-cadherin consistently over time. Clinical Trial Registration: ALBIOS ClinicalTrials.gov number NCT00707122.
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- 2021
12. PCSK9 is associated with mortality in patients with septic shock: data from the ALBIOS study
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Vecchie, A., Bonaventura, A., Meessen, J., Novelli, D., Minetti, S., Elia, E., Ferrara, D., Ansaldo, A. M., Scaravilli, V., Villa, S., Ferla, L., Caironi, P., Latini, R., Carbone, F., Montecucco, F., Bruzzone, P., Pagan, F., Russo, R., Confalonieri, A., Abbruzzese, C., Vergnano, B., Faenza, S., Siniscalchi, A., Pierucci, E., Noto, A., Pezzi, A., Spanu, P., Parrini, V., Oggioni, R., Pasetti, G. S., Casadio, M. C., Buontempo, R., Carrer, S., Piccoli, F., Rizzi, T., Caricato, A., La Sala, M., Antonaci, A., Fassini, P., Paganini, S., Porta, V., Moise, G., Marell, S., Furia, M., Urbano, M. C., Carobbi, R., Poleni, S., Kandil, H., Ballotta, A., Bettini, F., Sanseverino, M., Gatta, A., Cecchini, F., Guatteri, L., Ciceri, G., Raimondi, F., Colombo, R., Ferraris, S., Borelli, M., Bellato, V., Cancellieri, F., Senni, S., Sacchi, N., Ferri, P., Moioli, G., Fedele, A., Molin, A., Salati, G., Salsi, P., Brunori, E., Elisei, D., Maggio, G., Nicola, F. G., Cavana, M., Morelli, G., Guarino, A., Isetta, M., Tulli, G., Mangani, V., Rossi, N., Ferrari, M., Bona, F., Vay, M., Bartoli, T., Gallo, M., Morte, M. D., Boselli, E., Puscio, D., Galzerano, A., Carli, M., and Zagara, G.
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0301 basic medicine ,Male ,medicine.medical_specialty ,Inflammation ,030204 cardiovascular system & hematology ,Gastroenterology ,Sepsis ,PCSK9 ,sepsis ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Settore MED/41 - ANESTESIOLOGIA ,Internal Medicine ,Medicine ,Humans ,pentraxin 3 ,Aged ,business.industry ,Proportional hazards model ,Septic shock ,Septic ,Mortality rate ,mortality ,septic shock ,Biomarkers ,C-Reactive Protein ,Female ,Italy ,Middle Aged ,Proprotein Convertase 9 ,Serum Amyloid P-Component ,Shock, Septic ,Shock ,PTX3 ,medicine.disease ,030104 developmental biology ,Quartile ,Biomarker (medicine) ,medicine.symptom ,business - Abstract
Background Pro-protein convertase subtilisin/kexin 9 (PCSK9) is a proenzyme primarily known to regulate low-density lipoprotein receptor re-uptake on hepatocytes. Whether PCSK9 can concurrently trigger inflammation or not remains unclear. Here, we investigated the potential association between circulating levels of PCSK9 and mortality in patients with severe sepsis or septic shock. Methods Plasma PCSK9 levels at days 1, 2 and 7 were measured in 958 patients with severe sepsis or septic shock previously enrolled in the Albumin Italian Outcome Sepsis (ALBIOS) trial. Correlations between levels of PCSK9 and pentraxin 3 (PTX3), a biomarker of disease severity, were evaluated with ranked Spearman's coefficients. Cox proportional hazards models were used to assess the association of PCSK9 levels at day 1 with 28- and 90-day mortality. Results Median plasma PCSK9 levels were 278 [182-452] ng mL-1 on day 1. PCSK9 correlated positively with PTX3 at the three time-points, and patients with septic shock within the first quartile of PCSK9 showed higher levels of PTX3. Similar mortality rates were observed in patients with severe sepsis across PCSK9 quartiles. Patients with septic shock with lower PCSK9 levels on day 1 (within the first quartile) showed the highest 28- and 90-day mortality rate as compared to other quartiles. Conclusion In our sub-analysis of the ALBIOS trial, we found that patients with septic shock presenting with lower plasma PCSK9 levels experienced higher mortality rate. Further studies are warranted to better evaluate the pathophysiological role of PCSK9 in sepsis.
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- 2021
13. Andricus forni Pujade-Villar & Wang & Cuesta-Porta & Guo & Nicholls & Melika 2020, n. sp
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Pujade-Villar, Juli, Wang, Yiping, Cuesta-Porta, V��ctor, Guo, Rui, Nicholls, James A., and Melika, George
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Insecta ,Arthropoda ,Andricus forni ,Cynipidae ,Animalia ,Biodiversity ,Andricus ,Hymenoptera ,Taxonomy - Abstract
Andricus forni Pujade-Villar & Nicholls n. sp. urn:lsid:zoobank.org:act: C88FE778-168B-4094-BAC4-881F3D88AE7E (Figs 1���5) Type material. HOLOTYPE ♀: ��� Tianmushan, Lin���an District, Hangzhou City, Zhejiang Province ��� (white label); Q. glandulifera, (24.iv.2011) 27.iv.2011 (leg. Rui Guo) (white label); ��� Holotype ♀, Andricus forni n. sp. (desig. J. P-V)��� (red label). Holotype is deposited at UB (JP-V col.). Paratypes: 40�� & 40♀ (20�� & 20♀ at UB; 20�� & 20♀ at ZAFU) with the same labels as holotype. Additional material examined. Same data as holotype, 91�� & 37♀ (14�� & 10♀ UB, remainder at ZAFU). Tianmushan, Lin���an District, Hangzhou City, Zhejiang Province, Q. glandulifera (24.iv.2011) 25.iv..2011: 10�� & 7♀ (previously labeled as ��� Dryocosmus spp10��� and D. fabri in litt. det Wang). Kaishan Old Hall Attractions in Tianmu Mountain, Zhejiang Province, 11.v.1999: 1♀. Elephant Trunk Hill, Lin���an, Hangzhou City, Zhejuang Province, ex Q. glandul��fera var. brevipetiolata Nakai, Shijun Wang leg. (6.iv.2013) 23.iv.2013: 4�� & 9♀ (previ-ously labeled as ��� Dryocosmus spp4��� det Wang); same data (5.iv.2014) 28.iv.2014: 1�� & 22♀; same data (6.iv.2013) 23���26.iv.2013: 2♀; (23.iv.2013) 6.v.2013: 1♀. Changhua Town, Lin���an District, Hangzhou City, Zhejiang Province, Q. glandulifera, (12.iv.2013) 16.v.2014: 4♀ (previously labeled as ��� Dryocosmus spp8��� det Wang; the emergence date is a mistake, it should be 2013). Qingliangfeng, Lin���an District, Hangzhou City, Zhejiang Province, Q. glandulifera, (12.iv.2013) 2.v.2013: 1♀ (leg Jie, sample code 5132), 2♀ used for DNA; 21.iv.2015: 1♀ (leg. Jie 6191). Xiangbishan Lin���an District, Hangzhou City, Zhejiang Province, Q. glandulifera, (6.iv.2014) 23.iv.2014: 2♀ (leg. Jie, sample codes 5261, 5134). Diagnosis. Andricus forni n. sp. most closely resembles A. xishuangbannaus and A. moriokae by having the head anteriorly black, except on and around clypeus which is brown; malar space with striae; female antenna with F1 at most 1.2x as long as F2 while male antenna with last flagellomere at most 2.0x as long as broad and F1 slightly curved and not swollen apically; mesoscutum completely smooth or delicately alutaceous to smooth, only with very few setae along notauli and in the lateral corners;prominent part of the ventral spine of the hypopygium at most 4.0x as long as broad. In A. forni n. sp., lower face dark and strongly alutaceous to coriaceous, frons alutaceous, in females POL1.6x OOL, in males 2.0x OOL; female antenna with 12 flagellomeres (sometimes the suture between F11���F12 is incomplete but always visible), radial cell 3.5x as long as broad, central and lateral propodeal areas smooth, without wrinkles or rugae; lateral propodeal carinae complete, curved outwards posteriorly; galls on Q. serrata. In A. xishuangbannaus, only females are known, lower face light brown, smooth and shiny; frons smooth and shiny; central propodeal area with some irregular wrinkles and rugae, lateral propodeal area rugose, galls on Q. griffithii. Finally, Andricus moriokae differs from A. forni n. sp. by having a shorter POL in females (around 1.3x OOL), female antenna with 11 flagellomeres, the radial cell longer (4.1x as long as broad) and, in males, the lateral propodeal carinae are incomplete basally (ending at the level of dorsal propodeal margin). Etymology. Named after Mr. Joaquim Forn i Chiariello. Description. FEMALE. Body length 1.1���2.0 mm, n = 21. Color. Head, mesosoma and metasoma entirely and uniformly very dark brown to black; clypeus and mandibles brown, usually lighter than the rest of lower head (Fig. 5b); antenna light brown, last flagellomeres sometimes slightly darker; maxillary and labial palpi light yellow; tegula light brown; legs uniformly light brown, with coxae slightly darker at the base; ventral spine of hypopygium brown. Head (Fig. 1a, 1c, 1d) smooth, with sparse white setae on lower face; 2.0x broader than long in dorsal view, 1.3x broader than high and slightly broader than mesosoma in anterior view. Clypeus trapezoid, emarginate, with a weak median incision ventrally, weakly alutaceous, with some setae; anterior tentorial pits, epistomal sulcus and clypeo-pleurostomal line distinct, deep. Gena delicately alutaceous, not broadened behind eye, as long as diameter of eye in lateral view; malar space with delicate striae extending towards compound eye without reaching margin of eye, 0.3x shorter than height of eye. Compound eyes slightly convergent ventrally. Transfacial distance only 1.3x wider than height of eye; diameter of antennal toruli greater than distance between them, distance between torulus and inner margin of eye nearly equal to diameter of torulus; lower face, including slightly elevated median area, delicately coriaceous to alutaceous, with white setae. Frons and vertex delicately alutaceous, with few setae; interocellar area and occiput coriaceous. POL 1.6x broader than OOL; OOL 1.1���1.3x longer than LOL and around 2.0x longer than length of lateral ocellus; all ocelli of same size and shape. Postocciput and postgena smooth, shiny, without setae; posterior tentorial pit large, deep, the area below impressed; height of occipital foramen nearly equal to height of postgenal bridge; hypostomal carina emarginate, continuing into postgenal sulcus. Antenna (Fig. 2 a���b) with 12 flagellomeres, F11 longer than F12 (suture between F12 and F11 rarely incomplete); 1.3x longer than head+mesosoma; pedicel longer than broad; F1 around 1.1x longer than F2, 1.9x longer than pedicel; F2���F12 progressively shorter; placodeal sensilla on F2���F12, absent on F1. Antennal formula: 15: 12(x10): 23: 20: 17: 17: 16: 16: 15: 15: 15: 13: 12: 18. Mesosoma (Fig. 3 a���c) 1.15x longer than high. Pronotum smooth, shiny, with delicate parallel striae and dense white setae laterally; propleuron shiny, alutaceous to smooth anteriorly, with delicately coriaceous central and basal area. Mesoscutum smooth, shiny, with some white setae in the anterior corners and beside notauli; 1.2x wider than long (greatest width measured across mesoscutum at level of base of tegulae). Notauli complete, deep, slightly converging at the posterior end; anterior parallel, parapsidal, median mesoscutal lines absent; parascutal carina reaching notauli. Mesoscutellum rectangular, uniformly dull rugose to coriaceous, as long as broad, overhanging metanotum; circumscutelar carina usually well impressed; scutellar foveae distinct, transversely ovate, narrow, with smooth and shining bottom, with a very short coriaceous median carina separating foveae. Mesopleuron and speculum smooth, shiny, without setae except for dense patch of setae on posteroventral quarter of mesopleuron, with few impressed foveae along acetabular carina; dorsal axillar area smooth, shiny; axillula with dense white setae; lateral axillar area coriaceous, without setae, sometimes with a few rugae; subaxillular bar triangular, smooth, shiny, most posterior part broader than height of metanotal trough; metapleural sulcus reaching mesopleuron at almost half of its height. Metascutellum uniformly rugose-carinated, metanotal trough smooth, shiny, with dense short white setae; ventral impressed area shorter than height of metascutellum, smooth; central propodeal area smooth, shiny; lateral propodeal carinae strong, curved outwards in posterior third; lateral propodeal area smooth, rarely alutaceous, with a single ruga next to spiracle, with dense long white setae. Nucha with irregular wrinkles and rugae. Legs with tarsal claws with basal lobe. Forewing (Fig. 5a) longer than body, hyaline, with distinct long, dense cilia on margin, radial cell 3.5x longer than wide; R1 reaching wing margin, Rs nearly straight, reaching wing margin; areolet small, triangular, closed and distinct. Rs+M distinct at two-thirds of distance to basalis and its projection reaching basalis at mid-height. Metasoma (Fig. 4a) shorter than head+mesosoma, higher than long in lateral view; second metasomal tergite occupying more than half of metasoma in dorsal view, with some white setae laterally, all subsequent tergites without setae, smooth, shiny, with very delicate micropunctures. Hypopygium with micropunctures, ventral spine of hypopygium relatively short, prominent part 4.0x longer than broad, with two parallel rows of white setae ventrally. MALE (Figs. 1b, 1d, 1f, 2c, 3d, 4b). Similar to female except for: clypeus with the same color as lower face (rarely lighter); middle of last femur and last tibia also slightly darker; malar space around 0.2x as long as height of eye; transfacial distance around 1.1x wider than height of eye; gena 0.5x shorter than cross diameter of eye in lateral view; POL about 1.9x broader than OOL; OOL subequal in length to lateral ocellus, and 1.3x longer than LOL; central ocellus smaller; antenna with 15 flagellomeres; pedicel as long as broad; F1 very slightly curved and not swollen apically, 1.3���1.4x longer than F2, 2.5���2.6x longer than pedicel and 3.8-4.3x as long as its narrowest width; F3���F12 subequal in length; F1���F6 slightly wider than the remainder of flagellomeres; placodeal sensilla on all flagellomeres; antennal formula: 10: 8(x8): 21: 15: 14: 14: 13: 13: 13. 13: 12: 12(x7): 12: 11: 15. Body length 1.0��� 1.6 mm, n = 15 Gall. The gall (Fig. 5c) is integral to the leaf blade, occurring singularly, never in clusters, without a distinct internal larval chamber. The gall is approximately spherical, 2.6���3.1 mm in height (n=6), and the outer gall tissues protrude equally on both sides of the leaf lamina.Young galls are fleshy, yellowish to green, turning dry and dark brown after emergence of the adult wasps. Biology. Only the sexual generation is known, inducing galls on Q. serrata. Mature galls were collected in mid-April, adults emerge from mid-April to May. Distribution. Currently known only from Zhejiang Province, China. Probably distributed all over the range of its host plant. The host is native to southern, central and eastern China, also in Taiwan, Japan and Korea from 100 to 2000 m a.s.l. (Huang et al., 1999). After a thorough examination of specimens and original descriptions of A. pseudocurvator, A. songshui, A. formosanus and A. moriokae, the descriptions of A. mukaigawae, A. wuhanensis and A. xishuangbannaus, the redescription of A. moriokae, and additional literature mentioned in the discussion, we propose the following key to differentiate the sexual generations of the valid Andricus species obtained from small spherical integral leaf galls on oaks in the Eastern Palaearctic and Oriental Regions. We also note the host oaks galled by each Andricus species. 1 Anterior half of mesoscutum distinctly sculptured, strongly alutaceous to coriaceous....................... A. songshui [Q. serrata] - Mesoscutum completely smooth or with a very delicate alutaceous or imbricate sculpture mainly in the anterior corners.... 2 2 Mesoscutum obscurely imbricate with scattered hairs all over mesoscutum. Female F1 about 1.4x longer than F2................................................................................................. A. mukaigawae [Q. serrata, Q. mongolica var grosseserrata, Q. dentata] - Mesoscutum smooth or delicately alutaceous, with a few setae only along notauli and in the lateral corners, with glabrous areas. Female F1 shorter, at most 1.2x longer than F2.............................................................. 3 3 Females............................................................................................. 4 - Males.............................................................................................. 9 4 Prominent part of ventral spine of hypopygium at least 6.0x longer than broad..................................... 5 - Prominent part of ventral spine of hypopygium at most 4.0x longer than broad..................................... 6 5 Antenna with 11 flagellomeres (but the last sometimes with an indistinct suture, so appears as 12 flagellomeres); central propodeal area without or with few irregular delicate wrinkles........................................ A. pseudocurvator [Q. serrata, Q. fabrei] - Antenna with 11 flagellomeres; central propodeal area with irregular wrinkles.......................... A. wuhanensis [Q. fabrei] 6 Head brown anteriorly, especially lower face; malar space without striae, frons with distinct alutaceous sculpture.................................................................................................. A. formosanus [Q. dentata] - Head black anteriorly, any brown restricted to clypeus and around clypeus, malar space with striae; frons smooth, shiny or very delicately sculptured................................................................................... 7 7 Lower face and frons smooth and shiny; central propodeal area with some irregular wrinkles and rugae, lateral propodeal area rugose.............................................................................. A. xishuangbannaus [Q. griffithii] - Lower face and frons delicately alutaceous to coriaceous; central and lateral propodeal area smooth, without wrinkles and rugae............................................................................................... 8 8 POL about 1.6x as long as OOL; antenna with 12 flagellomeres, sometimes the suture between F11-F12 is incomplete; radial cell 3.5x as long as broad..................................................................... A. forni n. sp. [Q. serrata] - POL only 1.3x as long as OOL; antenna always with 11 flagellomeres, never with suture in F11; radial cell 4.1x as long as broad..................................................................................... A. moriokae [Q. serrata] 9 Last flagellomere more than 2x as long as broad............................................... A. pseudocurvator [Q. serrata, Q. fabrei] - Last flagellomere at most 2.0x as long as broad............................................................. 9 10 F1 apically swollen; body brown.............................................................. A. formosanus [Q. dentata] - F1 more cylindrical, very slightly curved and not swollen apically; body predominantly black....................... 10 11 POL around 2x as long as OOL; lateral propodeal carinae complete, curved outwards in posterior third....... A. forni n. sp. [Q. serrata] - POL around 1.6x as long as OOL; lateral propodeal carinae diverging ventrally and incomplete or inconspicuous basally, ending at level of dorsal propodeal margin........................................................... A. moriokae [Q. serrata] The cytb tree of Asian Andricus contains four major clades indicated with A���D in Fig. 6. Major clades A, C and D contain species with sexual generations inducing integral leaf galls. The species A. mukaigawae is recovered as monphyletic in a well-supported node, sister to the terminals of A. kashiwaphilus and A. pseudoflos, albeit the internal relationships between these two species is not well resolved. The new species, A. forni, is recovered as monophyletic within the clade C, closely allied to A. xishuangbannaus, A. moriokae, A. pseudocurvator and A. formosanus, as is also suggested by the morphological similarity of A. forni with this group, in particular with the first two species. Within this group, A. formosanus is the most phylogenetically distinct, while the remaining four form a genetically close complex of species. However, these four still show divergence consistent with being discrete species; for example the new species A. forni is 1.7���2.5% divergent from the other three species, within the range observed for other distinct cynipid species (Nicholls et al., 2018; Nicholls & Pujade-Villar, 2020). Finally, the species A. hakonensis and A. songshui are recovered within the clade D, which is sister to the rest of Andricus species, albeit the relationships between these two species is unclear. All new sequences are deposited in GenBank, accessions MT922013 ��� MT922034., Published as part of Pujade-Villar, Juli, Wang, Yiping, Cuesta-Porta, V��ctor, Guo, Rui, Nicholls, James A. & Melika, George, 2020, Andricus forni Pujade-Villar & Nicholls n. sp., a new species of oak gallwasp from China (Hymenoptera: Cynipidae), pp. 554-566 in Zootaxa 4890 (4) on pages 555-562, DOI: 10.11646/zootaxa.4890.4.7, http://zenodo.org/record/4306598, {"references":["Huang, C., Zhang, Y. & Bartholomew, B. (1999) Fagaceae. In: Wu, Z. - Y. & Raven, P. H. (Eds.), Flora of China. Vol. 4. Cycadaceae through Fagaceae. Science Press, Beijing and Missouri Botanical Garden Press, St. Louis, pp. 314 - 400. [on-line: http: // www. efloras. org / florataxon. aspx? flora _ id = 2 & taxon _ id = 10338]","Nicholls, J. A., Melika, G., DeMartini, J. & Stone, G. N. (2018) New species of Dryocosmus Giraud gallwasps from California (Hymenoptera: Cynipidae: Cynipini) galling Chrysolepis Hjelmq. (Fagaceae). Zootaxa, 4532 (3), 407 - 433. https: // doi. org / 10.11646 / zootaxa. 4532.3.6","Nicholls, J. A. & Pujade-Villar, J. (2020) Re-instatement of the species name Callirhytis erythrosoma (Dettmer, 1933), with comments on other Callirhytis species (Hymenoptera: Cynipidae). Butlletii de la Institucioi Catalana d'HistoIria Natural, 84, 31 - 34."]}
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- 2020
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14. Amphibolips salicifoliae Medianero & Nieves-Aldrey
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Cuesta-Porta, V��ctor, Equihua-Mart��nez, Armando, Estrada-Venegas, Edith G., Cibri��n-Tovar, David, Barrera-Ru��z, Uriel M., Silva, Salvador Ordaz, S��nchez, Imelda Virginia L��pez, Melika, George, and Pujade-Villar, Juli
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Insecta ,Arthropoda ,Cynipidae ,Amphibolips ,Animalia ,Biodiversity ,Amphibolips salicifoliae ,Hymenoptera ,Taxonomy - Abstract
Amphibolips salicifoliae Medianero & Nieves-Aldrey Amphibolips salicifoliae Medianero & Nieves-Aldrey, 2010: 55���60. Type material examined: HOLOTYPE. ♀ (deposited in MNCN), Cat n�� 2024. PANAMA, Chiriqu��, Volcan Baru 8�� 47��� 50 8��� N, 82�� 29��� 35 9��� W, 1800���2070m, Ex Q. salicifolia, (27.i.2009) ii.09, leg. E. Medianero. Paratypes: 2♂ & 2♀ with same data as the holotype (two paratypes deposited in MNCN, and two paratypes MEUP). Diagnosis. This species is characterized by the almost hyaline forewings in males and females, tarsal claws simple and notauli incomplete, short, distinct, with base of notaular groove smooth. This species closely resembles A. quercuspomiformis comb. nov. with which it shares the following character states: simple tarsal claws; mesoscutellum posteriorly not emarginated; speculum smooth and glabrous. Differs by the forewing colouration which is almost completely hyaline, slightly infuscate in A. salicifoliae (hyaline with dark patch at the base of radial cell in A. quercuspomiformis comb. nov.); notauli incomplete, broad, smooth, visible in posterior third of mesoscutum in A. salicifoliae (notauli complete, shallow, and partially covered by the sculpture of mesoscutum, furrow rugose in A. quercuspomiformis comb. nov.); median propodeal area shining, smooth in A. salicifoliae (dull rugose in A. quercuspomiformis comb. nov.); metasomal terga smooth without micropunctures in A. salicifoliae (posterior third of metasomal tergum II and subsequent tergum with micropunctures in A. quercuspomiformis comb. nov.). Galls of A. salicifoliae are subglobose, on the underside of leaves, very fragile, outer shell thin, hollow internally with thin filaments radiating from larval chamber while galls of A. quercuspomiformis comb. nov. are on buds, with outer shell hard, internal parenchyma spongious. Thin filaments radiating from the larval chamber to the outer shell in A. aliciae. We can differentiate these galls by the shape of the gall and its location (fusiform bud galls in A. aliciae and spherical leaf galls in A. salicifoliae) Host. Quercus salicifolia. Gall. Globose and fragile galls on the underside of leaves, with maximum diameter 30 mm; outer shell thin, internal space hollow with filaments radiating from the larval chamber. Larval chamber central or at the base of the gall (Medianero & Nieves-Aldrey 2010: Figs 8 G���H). Biology. The sexual generation is only known. Galls were collected in January; adults emerged in February. Distribution. Panama., Published as part of Cuesta-Porta, V��ctor, Equihua-Mart��nez, Armando, Estrada-Venegas, Edith G., Cibri��n-Tovar, David, Barrera-Ru��z, Uriel M., Silva, Salvador Ordaz, S��nchez, Imelda Virginia L��pez, Melika, George & Pujade-Villar, Juli, 2020, Revision of the Amphibolips species of the ' nassa' complex from Mexico and central America (Hymenoptera: Cynipidae), pp. 1-50 in Zootaxa 4877 (1) on page 32, DOI: 10.11646/zootaxa.4877.1.1, http://zenodo.org/record/4567340, {"references":["Medianero, E. & Nieves-Aldrey, J. L. (2010) The genus Amphibolips Reinhard (Hymenoptera: Cynipidae: Cynipini) in the Neotropics, with description of three new species from Panama. Zootaxa, 2360 (1), 47 - 62. https: // doi. org / 10.11646 / zootaxa. 2360.1.3"]}
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- 2020
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15. Amphibolips castroviejoi Medianero & Nieves-Aldrey
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Cuesta-Porta, V��ctor, Equihua-Mart��nez, Armando, Estrada-Venegas, Edith G., Cibri��n-Tovar, David, Barrera-Ru��z, Uriel M., Silva, Salvador Ordaz, S��nchez, Imelda Virginia L��pez, Melika, George, and Pujade-Villar, Juli
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Insecta ,Arthropoda ,Cynipidae ,Amphibolips ,Animalia ,Biodiversity ,Amphibolips castroviejoi ,Hymenoptera ,Taxonomy - Abstract
Amphibolips castroviejoi Medianero & Nieves-Aldrey Amphibolips castroviejoi Medianero & Nieves-Aldrey, 2010: 48���52 Type material examined: HOLOTYPE. ♀ deposited in MNCN (Cat. n�� 2022). PANAMA, Chiriqu��, Carretera de Volcancito, Boquete 8�� 43��� 23 07��� N, 82�� 27��� 19 07��� W, 1404 m, Ex Q. salicifolia, (28.i.2008) ii.08, E. Medianero leg. Paratypes: 1♂ with same data as holotype. Diagnosis. This species is characterized by heavily darkened forewings with a clear cross-band at the distal third that reaches posterior margin of forewing both in males and females, mesoscutellum subquadrate posteriorly, and metasoma predominantly black and rufo-piceous ventrally. The forewing pattern most closely resembles the species group of A. bassae n. sp., A. bromus n. sp., A. cibriani and A. fusus for the distal clear cross-band that reaches posterior margin of wing, but the forewings of A. castroviejoi are completely darkened except for the distal cross-band (proximal half of forewing is hyaline in the rest of species, except for the male of A. bassae n. sp. which is completely infuscate except for a clear spot at the distal half of radial cell). The species most closely resembles A. basssae n. sp. by the similar coarse sculpture of mesoscutum and mesoscutellum, but median sulci on the mesoscutum are absent in A. castroviejoi (present in A. bassae n. sp.), metasoma is black and rufo-piceous ventrally in A. castroviejoi (ambarine to rufous in A. bassae n. sp.). Galls of A. castroviejoi are differ from all other known galls; they are large (on average 54 x 43 mm), irregularly spherical or globose, elongated at the base, with a thick peduncle, without apical tip, and with a smooth, mottled surface. Gall. A globose bud gall, 45���58 mm in diameter, with short elongation at the base forming a thick peduncle. Light green and mottled when mature, turning light brown when dry. Outer shell thin, hard. Internal parenchyma soft and spongious. Central larval chamber with a hard shell, 5���6 mm in diameter. A picture of the gall is given in Medianero & Nieves-Aldrey (2010: Figs 8 A���C). Host. Quercus salicifolia. Biology. Only the sexual generation is known. Galls were collected in January; adults emerged in February. Distribution. Panama., Published as part of Cuesta-Porta, V��ctor, Equihua-Mart��nez, Armando, Estrada-Venegas, Edith G., Cibri��n-Tovar, David, Barrera-Ru��z, Uriel M., Silva, Salvador Ordaz, S��nchez, Imelda Virginia L��pez, Melika, George & Pujade-Villar, Juli, 2020, Revision of the Amphibolips species of the ' nassa' complex from Mexico and central America (Hymenoptera: Cynipidae), pp. 1-50 in Zootaxa 4877 (1) on page 11, DOI: 10.11646/zootaxa.4877.1.1, http://zenodo.org/record/4567340, {"references":["Medianero, E. & Nieves-Aldrey, J. L. (2010) The genus Amphibolips Reinhard (Hymenoptera: Cynipidae: Cynipini) in the Neotropics, with description of three new species from Panama. Zootaxa, 2360 (1), 47 - 62. https: // doi. org / 10.11646 / zootaxa. 2360.1.3"]}
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- 2020
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16. PCSK9 is associated with mortality in patients with septic shock: data from the ALBIOS study
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Vecchie, A., Bonaventura, A., Meessen, J., Novelli, D., Minetti, S., Elia, E., Ferrara, D., Ansaldo, A. M., Scaravilli, V., Villa, S., Ferla, L., Caironi, P., Latini, R., Carbone, F., Montecucco, F., Bruzzone, P., Pagan, F., Russo, R., Confalonieri, A., Abbruzzese, C., Vergnano, B., Faenza, S., Siniscalchi, A., Pierucci, E., Noto, A., Pezzi, A., Spanu, P., Parrini, V., Oggioni, R., Pasetti, G. S., Casadio, M. C., Buontempo, R., Carrer, S., Piccoli, F., Rizzi, T., Caricato, Anselmo, La Sala, M., Antonaci, A., Fassini, P., Paganini, S., Porta, V., Moise, G., Marell, S., Furia, M., Urbano, M. C., Carobbi, R., Poleni, S., Kandil, H., Ballotta, A., Bettini, F., Sanseverino, M., Gatta, A., Cecchini, F., Guatteri, L., Ciceri, G., Raimondi, F., Colombo, R., Ferraris, S., Borelli, M., Bellato, V., Cancellieri, F., Senni, S., Sacchi, N., Ferri, P., Moioli, G., Fedele, A., Molin, A., Salati, G., Salsi, P., Brunori, E., Elisei, D., Maggio, G., Nicola, F. G., Cavana, M., Morelli, G., Guarino, A., Isetta, M., Tulli, G., Mangani, V., Rossi, N., Ferrari, M., Bona, F., Vay, M., Bartoli, T., Gallo, M., Morte, M. D., Boselli, E., Puscio, D., Galzerano, A., Carli, M., Zagara, G., Caricato A. (ORCID:0000-0001-5929-120X), Vecchie, A., Bonaventura, A., Meessen, J., Novelli, D., Minetti, S., Elia, E., Ferrara, D., Ansaldo, A. M., Scaravilli, V., Villa, S., Ferla, L., Caironi, P., Latini, R., Carbone, F., Montecucco, F., Bruzzone, P., Pagan, F., Russo, R., Confalonieri, A., Abbruzzese, C., Vergnano, B., Faenza, S., Siniscalchi, A., Pierucci, E., Noto, A., Pezzi, A., Spanu, P., Parrini, V., Oggioni, R., Pasetti, G. S., Casadio, M. C., Buontempo, R., Carrer, S., Piccoli, F., Rizzi, T., Caricato, Anselmo, La Sala, M., Antonaci, A., Fassini, P., Paganini, S., Porta, V., Moise, G., Marell, S., Furia, M., Urbano, M. C., Carobbi, R., Poleni, S., Kandil, H., Ballotta, A., Bettini, F., Sanseverino, M., Gatta, A., Cecchini, F., Guatteri, L., Ciceri, G., Raimondi, F., Colombo, R., Ferraris, S., Borelli, M., Bellato, V., Cancellieri, F., Senni, S., Sacchi, N., Ferri, P., Moioli, G., Fedele, A., Molin, A., Salati, G., Salsi, P., Brunori, E., Elisei, D., Maggio, G., Nicola, F. G., Cavana, M., Morelli, G., Guarino, A., Isetta, M., Tulli, G., Mangani, V., Rossi, N., Ferrari, M., Bona, F., Vay, M., Bartoli, T., Gallo, M., Morte, M. D., Boselli, E., Puscio, D., Galzerano, A., Carli, M., Zagara, G., and Caricato A. (ORCID:0000-0001-5929-120X)
- Abstract
Background: Pro-protein convertase subtilisin/kexin 9 (PCSK9) is a proenzyme primarily known to regulate low-density lipoprotein receptor re-uptake on hepatocytes. Whether PCSK9 can concurrently trigger inflammation or not remains unclear. Here, we investigated the potential association between circulating levels of PCSK9 and mortality in patients with severe sepsis or septic shock. Methods: Plasma PCSK9 levels at days 1, 2 and 7 were measured in 958 patients with severe sepsis or septic shock previously enrolled in the Albumin Italian Outcome Sepsis (ALBIOS) trial. Correlations between levels of PCSK9 and pentraxin 3 (PTX3), a biomarker of disease severity, were evaluated with ranked Spearman’s coefficients. Cox proportional hazards models were used to assess the association of PCSK9 levels at day 1 with 28- and 90-day mortality. Results: Median plasma PCSK9 levels were 278 [182–452] ng mL−1 on day 1. PCSK9 correlated positively with PTX3 at the three time-points, and patients with septic shock within the first quartile of PCSK9 showed higher levels of PTX3. Similar mortality rates were observed in patients with severe sepsis across PCSK9 quartiles. Patients with septic shock with lower PCSK9 levels on day 1 (within the first quartile) showed the highest 28- and 90-day mortality rate as compared to other quartiles. Conclusion: In our sub-analysis of the ALBIOS trial, we found that patients with septic shock presenting with lower plasma PCSK9 levels experienced higher mortality rate. Further studies are warranted to better evaluate the pathophysiological role of PCSK9 in sepsis.
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- 2020
17. 1869P Pain in cancer: The patient experience in Spain
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Garcia-Foncillas, J., primary, Anton, A., additional, Caballero Martinez, F., additional, Feijoo, M., additional, Gomez de Liano, A., additional, Guillem Porta, V., additional, Monge, D., additional, Campos Lucas, F.J., additional, and Camps Herrero, C.J.C., additional
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- 2020
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18. Portosplenic venous gas and splenic abscess: a case report and review of the literature
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FASSINI, P., FERRARA, R. M., MORRA, S., FERLA, L., PORTA, V., and RADRIZZANI, D.
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- 2009
19. Evaluation of the bioequivalence of capsules containing 150 mg of fluconazole
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Porta, V., Chang, K.H., and Storpirtis, S.
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- 2005
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20. Fotemustine Compared With Dacarbazine in Patients With Disseminated Malignant Melanoma: A Phase III Study
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Avril, M F., Aamdal, S, Grob, J J., Hauschild, A, Mohr, P, Bonerandi, J J., Weichenthal, M, Neuber, K, Bieber, T, Gilde, K, Porta, V Guillem, Fra, J, Bonneterre, J, Saïag, P, Kamanabrou, D, Pehamberger, H, Sufliarsky, J, Gonzalez Larriba, J L., Scherrer, A, and Menu, Y
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- 2004
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21. Opening the ICU: views of ICU doctors and nurses before and after liberalization of visiting policies
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Giannini, A, Miccinesi, G, Prandi, E, Audisio, M, Bencivinni, A, Biagioni, E, Castenetto, E, Laganà, I, Oggioni, R, Porta, V, Salcuni, R, Sarti, A, Visconti, MG, and Borreani, C
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- 2012
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22. Influence of burnout on attitudes of ICU doctors and nurses towards liberalization of visiting polices
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Giannini, A, Miccinesi, G, Prandi, E, Audisio, M, Bencivinni, A, Biagioni, E, Castenetto, E, Laganà, I, Oggioni, R, Porta, V, Salcuni, R, Sarti, A, Visconti, MG, and Borreani, C
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- 2012
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23. Reversed-phase ion-interaction chromatography of metal ions by EDTA precomplexation
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Sacchero, G., Abollino, O., Porta, V., Sarzanini, C., and Mentasti, E.
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- 1991
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24. Chromatographic behaviour of homologous amines: Comparison of derivatizing agents, columns and mobile phases
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Mentasti, E., Sarzanini, C., Abollino, O., and Porta, V.
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- 1991
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25. Randomized, double-blind, multicenter trial comparing two doses of arzoxifene (LY353381) in hormone-sensitive advanced or metastatic breast cancer patients
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Baselga, J., Llombart-Cussac, A., Bellet, M., Guillem-Porta, V., Enas, N., Krejcy, K., Carrasco, E., Kayitalire, L., Kuta, M., Lluch, A., Vodvarka, P., Kerbrat, P., Namer, M., and Petruzelka, L.
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- 2003
26. Simultaneous ion chromatographic determination of selenium and metal ions in waters at trace level
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Sarzanini, C., Abollino, O., Mentasti, E., and Porta, V.
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- 1990
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27. Gatesina Pujade-Villar, Cuesta-Porta & Hanson 2018, n. gen
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Cuesta-Porta, V��ctor, Caicedo, Guadalupe, Hanson, Paul, and Pujade-Villar, Juli
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Eurytomidae ,Insecta ,Arthropoda ,Gatesina ,Animalia ,Biodiversity ,Hymenoptera ,Taxonomy - Abstract
Gatesina Pujade-Villar, Cuesta-Porta & Hanson n. gen. Type species. Gatesina colombiana n. sp., monotypic. Diagnosis. Females of Gatesina differ from those of other genera of Rileyinae in the morphology of the metasoma, which is laterally compressed, with the posterior part bent dorsally upwards, and with gastral tergites 6���8 and the ovipositor perpendicular to the longitudinal axis of the body (Figs 17, 19, 20). Other Rileyinae usually do not have the metasoma bent like this and never to such an extent. Five other characteristics different from most other Rileyinae (Lotfalizadeh 2007; Gates 2008; Caicedo & Pujade-Villar 2017) are: (i) epicnemium with smooth ovate depression with sparse long setae and bordered by a faint carina (Fig. 12) (other Rileyinae usually have longitudinal glabrous sulci, but never this structure); (ii) prosternum with mesal, laminate and setose projection on ventral side (Fig. 12); (iii) distance between toruli less than their diameter (Figs 1, 2) (in other Rileyinae the distance between toruli is usually greater than their diameter, except some Rileya Ashmead 1888); (iv) postgenal bridge slightly concave and not carinately margined (Figs 4, 5) (usually delimited by a strong depression or carina in other Rileyinae); (v) propodeal spiracles round (in other Rileyinae usually elongate and transversely or obliquely oriented). The new genus is morphologically similar to Neorileya Ashmead 1904, but differs, in besides the aforementioned characters, the following four features: (i) clypeus with 6 sparse setae that surpass the ventral clypeal margin and without a carina reaching intertorular space (Figs 1���3) (glabrous in Neorileya except for two setae on each lateral margin of clypeus and with medial carina reaching intertorular space), (ii) frons finely strigose (Figs. 1, 2) (coarsely reticulate to umbilicate in Neorileya), (iii) lower margin of eye midway between toruli and clypeus (Figs 1, 2) (nearly at clypeal level in Neorileya), and (iv) with a faint, oblique carina connecting metacoxa and nucha, but transverse carina connecting metacoxae absent (Fig. 10) (Neorileya with oblique metacoxal-nuchal carina absent, but inter-metacoxal transverse carina present). Moreover, a mesepimeral-metapleural junction is present, with a tongue visible but not overlapping the metapleuron (Fig. 13) (absent from Neorileya; present in Platyrileya Burks 1971 and Rileya, but tongue overlapping metapleuron in Rileya). Etymology. This genus is named in honor of Michael W. Gates (Smithsonian Institution, Washington, USA) for all his work and contribution to hymenopteran research, especially to the Rileyinae and the family Eurytomidae as a whole. Gender. Feminine. Biology. Parasitoid of gall-inducing Eurytominae in Myrcianthes (Myrtaceae) fruits. Two possible hosts known so far: Sycophila n. sp. and Eurytoma n. sp. Both phytophagous species attack on Myrcianthes fruits and can coexist in the same gall. Eurytoma larvae chamber substitutes the fruit���s seeds. Sycophila larvae chamber is placed in the hyperplasic mesocarp near the limit with exocarp. Gatesina has always been found in external chambers similar to Sycophila. Caicedo & Pujade-Villar (2017) also found correlation between Sycophila and Gatesina emergence of the adults. Sycophila is very likely to be parasitized by Gatesina, but Eurytoma or other hosts are not discarded. Distribution. Colombia., Published as part of Cuesta-Porta, V��ctor, Caicedo, Guadalupe, Hanson, Paul & Pujade-Villar, Juli, 2018, Gatesina colombiana n. gen. & n. sp. (Hymenoptera: Chalcidoidea, Eurytomidae), new Rileyinae associated with Myrcianthes (Myrtaceae) from Colombia, pp. 111-124 in Zootaxa 4471 (1) on pages 114-115, DOI: 10.11646/zootaxa.4471.1.4, http://zenodo.org/record/1439553, {"references":["Lotfalizadeh, H., Delvare, G. & Rasplus, J. Y. (2007) Phylogenetic analysis of Eurytominae (Chalcidoidea: Eurytomidae) based on morphological characters. Zoological Journal of the Linnean Society, 151 (3), 441 - 510. https: // doi. org / 10.1111 / j. 1096 - 3642.2007.00308. x","Gates, M. (2008) Species Revision and Generic Systematics of World Rileyinae (Hymenoptera: Eurytomidae). Uol. 127. University of California Publications in Entomology, California, 332 pp.","Caicedo, G. & Pujade-Villar, J. (2017) Gallicolous, phytophagous and parasitoid insects associated with Myrcianthes (Myrtaceae) fruits in Colombia. Dugesiana, 24 (2), 239 - 250.","Burks, B. D. (1971) A synopsis of the genera of the family Eurytomidae (Hymenoptera: Chalcidoidea). Transactions of the American Entomological Society, 97 (1), 1 - 89."]}
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- 2018
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28. Gatesina colombiana Cuesta-Porta & Caicedo & Hanson & Pujade-Villar 2018, n. sp
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Cuesta-Porta, V��ctor, Caicedo, Guadalupe, Hanson, Paul, and Pujade-Villar, Juli
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Eurytomidae ,Gatesina colombiana ,Insecta ,Arthropoda ,Gatesina ,Animalia ,Biodiversity ,Hymenoptera ,Taxonomy - Abstract
Gatesina colombiana Pujade-Villar, Caicedo & Cuesta-Porta n. sp. Figs 1���22 Type material. HOLOTYPE ♀, deposited in IAvH, with the following labels: ���J. B. Jos�� Celestino Mutis (Bogot�� D.C., Cundinamarca, Colombia), 4.6682581 N, 74.1000085 W, (16���xii���2007) 17/ 25���i���2008, Ex Myrcianthes rhopaloides, G. Caicedo leg.��� (white label); ���Holotype ♀, Gatesina colombiana n. sp. Pujade-Villar, Caicedo & Cuesta-Porta, desig. 2018��� (red label). PARATYPES (46♂ 59♀): 16♂ 8♀, same data as Holotype (9♂ 3♀ IAvH and 7♂ 5♀ col. UB), (26���i���2011) 22���ii���2011: 1♂ 12♀ (IAvH); Bogot�� D.C. (Cundinamarca, Colombia), Ex Myrcianthes rhopaloides, v���2000: 5♂ 11♀ (UB), G. Caicedo leg.; Engativ�� (Bogot��, Cundinamarca, Colombia), 4.6858718 N, 74.0805436 W, Ex Myrcianthes rhopaloides, (16���vii���2012) 07���viii���2012: 3♂ 10♀ (IAvH), G. Caicedo leg.; J.B. B (Bogot��, Cundinamarca, Colombia), Ex Myrcianthes leucoxyla, (30���ix���2010) 12���x���2010: 5♂ (IAvH), Caicedo leg.; Teusaquillo, (Bogot��, Cundinamarca, Colombia), 4.6374074 N, 74.0848960 W, Ex Myrcianthes leucoxyla, (10���viii���2007) 10���viii���2007: 4♂ 4♀ (IAvH), G. Caicedo leg.; Vereda Olarte (Usme, Cundinamarca, Colombia), 4.4424940 N, 74.1335230 W, Ex Myrcianthes leucoxyla, (23���x���2010) 27���x���2010: 3♂ 2♀ (UB), G. Caicedo leg.; Mochuelo alto, Ciudad Bol��var (Bogot��, Cundinamarca, Colombia), 4.5257735 N, 74.1410898 W, Ex Myrcianthes leucoxyla (30���ix���2010) 03���x���2010: 3♂ 4♀ (CNC), 3♂ 4♀ (UB), 3♂ 4♀ (USNM), Caicedo leg. Additional material (65♂ & 67♀). Jard��n Bot��nico Jos�� Celestino Mutis (JBB) (Bogot��, Cundinamarca, Colombia), 4.6682581 N, 74.1000085 W, Ex Myrcianthes rhopaloides, (09���viii���2007) viii���2009: 1♂ 1♀ (IAvH), (05���iii���2008): 1♀ (IAvH), (08���vii���2009), 13���vii���2009: 2♂ 7♀ (IAvH), (11���xi���2009) 05���xii���2009: 1♀ (IAvH), (31���viii���2010) 08���ix / 05���x���2010: 4♂ 10♀ (IAvH), (07���i���2011) 07���i���2011: 2♂ 4♀ (IAvH), (21���i���2011) 25���ii��� 2011: 1♂ (IAvH), G. Caicedo leg.; JBB (Bogot��, Cundinamarca, Colombia), Ex Myrcianthes ���intermediate type ���, (17���ix���2010) 18/ 25���ix���2010: 4♂ 1♀ (IAvH), G. Caicedo leg.; JBB (Bogot��, Cundinamarca, Colombia), Ex Myrcianthes leucoxyla, (07���i���2010) 22���iii���2010: 1♂ (IAvH), (30���ix���2010) 10���x���2010: 1♂ 3♀ (IAvH), Caicedo leg.; Engativ�� (Bogot��, Cundinamarca, Colombia), 4.6858718 N, 74.0805436 W, Ex Myrcianthes rhopaloides, (16���vi���2012) 24���vii���2012: 3♂ (IAvH), G. Caicedo leg.; Vereda Olarte (Usme, Cundinamarca, Colombia), 4.4424940 N, 74.1335230 W, Ex Myrcianthes leucoxyla, (14���xii���2010) 23���xii���2010: 7♂ 10♀ (UB), (20���i���2011) 18���ii���2011: 4♀ (IAvH), G. Caicedo leg.; Teusaquillo, (Bogot��, Cundinamarca, Colombia), Ex Myrcianthes leucoxyla, (12���i���2010) 23���i / 11���ii���2010: 7♂ 2♀ (IAvH), G. Caicedo leg.; Bogot�� D.C. (Cundinamarca, Colombia), Ex Myrcianthes rhopaloides, v���2000: 2♀ (UB), G. Caicedo leg.; Ministerio de defensa (Bogot��, Cundinamarca, Colombia), 4.6447300 N, 74.0956400 W, Ex Myrcianthes rhopaloides (01���xi���2009) 01���xi���2009: 1♂ (IAvH), G. Caicedo leg.; Estaci��n Avenida Rojas (Bogot��, Cundinamarca, Colombia), 4.6617055 N, 74.1092373 W, Ex Myrcianthes ���rough type ���, (12���i���2012) 21���i���2012: 1♂ 1♀ (IAvH), G, Caicedo leg.; Centro Administrativo Nacional (CAM) (Bogot��, Cundinamarca, Colombia), 4.6453341 N, 74.0953653 W, Ex Myrcianthes leucoxyla, (12���i���2010) 21���i���2010: 3♂ (IAvH), G. Caicedo leg.; Parque Mirador de los Nevados, Suba (Bogot��, Cundinamarca, Colombia), 4.7422268 N, 74.0806013 W, Ex Myrcianthes leucoxyla, (25���iv���2010) 13���v���2010: 1♂ 1♀ (IAvH), G. Caicedo leg.; Engativ�� (Bogot��, Cundinamarca, Colombia), 4.6858718 N, 74.0805436 W, Ex Myrcianthes rhopaloides, (17���ii���2014) 27���ii���2014: 20♂ 15♀ (UB), Caicedo leg.; Do��a Juana, Ciudad Bol��var (Bogot��, Cundinamarca, Colombia) 4.4982951 N, 74.1426887 W, Ex Myrcianthes leucoxyla, (30���ix���2010) 15���x��� 2010: 5♂ 1♀ (IAvH), G. Caicedo leg.; Humedal de Santa Maria de Lago (Bogot��, Cundinamarca, Colombia), 4.6947098 N, 74.0929792 W, Ex Myrcianthes leucoxyla, (13���x���2010): 1♂ 3♀ (IAvH), G. Caicedo leg. Description. FEMALE (Figs 1, 3, 4, 6, 7, 9, 10, 12���14, 16, 17, 19, 20). Length 2.7���5.1 mm (n = 60). Color (Figs 19, 20). Mainly amber with darker parts dorsally. Head amber with black area variable in size, but always covering ocellar area and never reaching dorsal margin of eyes. Mesosoma amber; pronotum dorsally blackened in middle third; mesoscutum dorsally black covering notauli, posterodorsal amber area with triangular to rhomboidal shape usually present; scutellum dark-brown to black, often with anterior amber stain continuous with amber part of mesoscutum. Metasoma amber with dorsal part darkened, forming a thin longitudinal stripe not wider than 0.25�� total height of metasoma in lateral view; 7th gastral segment not darkened; 8th gastral segment strongly darkened. Ovipositor amber colored. Wings hyaline. Legs yellowish-amber, usually lighter than the body. Head (Figs 1, 3, 4). Subtrapezoidal in frontal view. Distance between posterior ocelli equal to distance between posterior and anterior ocellus, forming an equilateral triangle. Distance between eye and posterior ocellus similar to distance between mesal margins of posterior ocelli. Anterior ocellus outside scrobal depression. Upper face rugulose to finely carinate and sparsely pubescent. Scrobal depression laterally margined; smooth except for the upper margin where sculpture gradually becomes rugulose and elevates to merge with upper face; rugulose sculpture extends into median part of scrobal depression forming a right angle with the vertex, and extending ventrally to center of depression. Intertorular space smooth. Lower face with crests radiating from clypeus; striations almost glabrous, but sparse pubescence below intertorular space and near anteroventral eye margin extending to upper face. Malar space 0.3���0.4�� eye height. Eye facets equal in size. Clypeus concave and emarginate; 6 long setae surrounding clypeus and surpassing its ventral margin. Gena strongly carinate from clypeus to malar space, then bifurcating in subgenal area, with faint postorbital carina; posteriorly faintly carinate and without tooth above lateral edge of oral fossa as is usually the case in Rileyinae. Vertex regularly arcuate; pubescence and sculpture as for upper face and posterior gena. Occiput glabrous and with imbricate sculpture. Postgenal groove present on both sides of foramen magnum, ventrally emarginate. Postgenal bridge slightly depressed relative to occiput; finely imbricate with faint transverse striations and sparsely pubescent; median stripe 0.33�� distance between tentorial pits, with longitudinal cuticular folds and digitiform expansions (about10 ��m long). Postgenal sulci deep, ventrally convergent and inner margin of sulci overlapping outer margin. Post genal depression forming subventral tooth at level of gena-postgena; delimited dorsally by a carina which is laterally connected to subgenal carina. Hypostomal bridge present, connecting both hypostomal carinae, which borders the hypostomal fossa. Antennae (Figs 6, 7) 13-segmented with characteristic Rileyinae antennal formula: 1:1:2:6:3. Scape 3.0�� longer than its maximum width; depression to accommodate funicle present on distal half of ventral surface. Pedicel as long as broad or slightly longer; slightly dorsoventrally asymmetrical; pedicel bent towards ventral side creating an antennal curvature in lateral view. Both anelli transverse with single row of setae on distal margin; total length similar to first funicular segment. Funicular segments subquadrate (0.6���0.7�� as long as broad); sensilla and setae similar in length. Clava 2�� longer than broad; first segment clearly visible, second and third segments fused. Mesosoma (Figs 9���14, 16). Pronotum and mesoscutum with discontinuous fine transverse striae; interstices alutaceous and with sparse homogeneous pubescence. Pronotum 0.5���0.6�� as long as mesoscutum in dorsal view; lateral depression glabrous and with fine imbricate sculpture at level of prepectus; collar anteriorly emarginate. Prosternum showing a mesal, laminate and setose projection. Prepectus in lateral view 0.4���0.5�� as long as tegula and ventrally emarginate; hardly visible in ventral view, deeply depressed, margined by procoxal insertion anteriorly, by epicnemium posteriorly and laterally by pronotal lateral projections. Mesothoracic spiracle not visible between prepectus, pronotum and mesoscutum. Mesothorax 1.6�� higher than pronotum in lateral view. Mesopleuron mostly smooth and glabrous, mesepimeron posteriorly striate. Mesepisternum separated from mesepimeron by a notch. Adscrobal area laterally margined by adscrobal carina; dorsal third smooth and glabrous, reticulate sculpture and pubescent in lower third; ventral third inclined and forming a bevel. Epicnemium differentiated from adscrobal area by a change in sculpture, finely imbricate and glabrous; median part raised towards anterior prothorax, more steeply projecting in dorsal part; medioventral area slightly depressed relative to rest of epicnemium; depression smooth and pubescent, emarginate, forming an oval-shaped structure; ventral part of epicnemium delimited by a strong ventrally projected carina, merging laterally with adscrobal area. Notauli complete but superficial. Mesoscutellum 0.8�� as long as broad, finely alveolate with coriaceous interstices; axillar grooves superficial and separated from one another by transscutal line; posterior scutellar margin ecarinate and projecting slightly above propodeum. Postscutellum partially covered by scutellar projection; with fine longitudinal carinae; with transverse carina on posterior margin that becomes weaker medially. Propodeum with fine transverse to oblique discontinuous longitudinal carinae and alutaceous interstices; with strongly raised median and transverse carina; longitudinal carinae radiating from nucha to transverse carina, two on each side of median carina; in posterior view two rows of setae converging from beneath level of spiracle to inferior margin of nucha; spiracles round. Legs (Figs 16, 19���22). Procoxa finely striate, proximal and distal depressions present and ecarinate; sparse anterior pubescence between both depressions not reaching inner margin of distal depression; triangle-shaped cuticular projection curved downwards, covering anterior part of distal depression and trochanter. Mesocoxa laterally pubescent except for a distal glabrous area reaching its maximum width near trochanter insertion and narrowing towards center of mesocoxa. Metacoxa 2.1���2.3�� longer than mesocoxa; posterior surface glabrous, with transverse striae, distally margined by strong carina; anterior surface pubescent near proximal and distal margins, glabrous in median part and with imbricate sculpture; lateral surface with a longitudinal band of setae not broader than 1/5 maximum metacoxal width, this band separating the two sculptured surfaces. Tarsal claws with small basal tooth. Front wings (Figs 19, 20) hyaline. Marginal vein thickened, 2�� wider than postmarginal vein. Stigmal vein short and 0.5�� as wide as marginal vein and then broadened into a stigma 2�� broader than marginal vein. Postmarginal vein 1.2���1.6�� as long as marginal vein. Metasoma (Figs 17, 19, 20). Virtually sessile. Petiole transverse and not dorsally visible. Gaster strongly compressed laterally. First tergite reduced, not reaching ventral gastral margin; smooth, with sparse lateral pubescence. Second gastral tergite reduced in dorsal view, 0.33�� as long as first tergite; glabrous. Third gastral tergite equal to or slightly longer than fourth tergite and as long as the combined length of GsT1+ GsT2; with fine imbricate sculpture and few setae distributed on lateral surfaces. GsT4���T6 with same sculpture as GsT3, but pubescence more extended on lateral surfaces, and equal in length to GsT5+GsT6. GsT6���T8 dorsally curved, forming a right angle. Syntergum and ovipositor perpendicular to longitudinal axis of body. MALE (Figs 2, 5, 8, 11, 15, 18, 21, 22). Similar to female except: average body length shorter (1.8���4.6 mm, n=46); color similar to female or more uniformly colored, ranging from dark-brown to yellowish-amber (smallest individuals tend to be darker colored and larger individuals lighter and more yellowish). Fine longitudinal carina in center of antennal scrobe, originating from center of depression and merging with elevated and finely carinate dorsal margin. Scape with ventral depression 0.6�� as long as female depression, occupying distal third of scape. Petiole visible; rugulose-granulate, glabrous; quadrate in lateral view, 1.2�� longer than broad in dorsal view; petiole tergite highly convex and inserted into dorsal part of GsT1; strong transverse carina surrounding anterior margin of petiole dorsally and laterally, carina ending in two ventral spurs. Metasoma pyriform, broadened on fourth and fifth gastral segments, not compressed. GsT1 not noticeably reduced, 2�� longer than petiole laterally and equal to the sum of GsT2+GsT3; with V-shaped notch in dorsal view, due to petiole insertion; smooth and with scattered setae laterally. GsT2 reduced, 0.13���0.10�� as long as GsT1 dorsally; smooth and glabrous. GsT3���T6 smooth at their posterior margin and imbricate-alutaceous in central parts; with sparse pubescence. GsT3 slightly shorter than GsT4, the latter similar in length to GsT5. GsT6 0.20���0.25�� as long as GsT5. Metasoma not dorsally bent, syntergum horizontal. Etymology. In reference to the country where this specie has been found (Colombia). Gender. Feminine. Biology. Parasitoid of Eurytominae found in Myrcianthes (Myrtaceae) fruit galls (Caicedo & Pujade-Villar 2017)., Published as part of Cuesta-Porta, V��ctor, Caicedo, Guadalupe, Hanson, Paul & Pujade-Villar, Juli, 2018, Gatesina colombiana n. gen. & n. sp. (Hymenoptera: Chalcidoidea, Eurytomidae), new Rileyinae associated with Myrcianthes (Myrtaceae) from Colombia, pp. 111-124 in Zootaxa 4471 (1) on pages 115-121, DOI: 10.11646/zootaxa.4471.1.4, http://zenodo.org/record/1439553, {"references":["Caicedo, G. & Pujade-Villar, J. (2017) Gallicolous, phytophagous and parasitoid insects associated with Myrcianthes (Myrtaceae) fruits in Colombia. Dugesiana, 24 (2), 239 - 250."]}
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- 2018
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29. Prognostic Value of Tumour-Infiltrating Lymphocytes Changes between Pre and Post-Neoadjuvant Treatment and in Residual Disease in Triple Negative Breast Cancer
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Herrero-Vicent, C, primary, Calatrava, A, additional, Ramírez, M, additional, Gavilá, J, additional, Guerrero, A, additional, Hernández-Serra, A, additional, Lopez-Guerrero, JA, additional, Guillem-Porta, V, additional, and Ruiz-Simón, A, additional
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- 2019
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30. Clinical practice evaluation of opioids induced constipation management in cancer patients: The EIO-Praxis project
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Aranda Aguilar, E., primary, Garcia Foncillas, J., additional, Antón, A., additional, Camps Herrero, C.J., additional, Carrato Mena, A., additional, Constenla Figueiras, M., additional, Cruz Hernandez, J.J., additional, Diaz Rubio, E., additional, Gascon, P.N., additional, Guillem Porta, V., additional, López, R., additional, Feyjóo, M., additional, and Puente, J., additional
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- 2019
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31. Oncologist’s knowledge and implementation of guidelines for breakthrough cancer pain in Spain: CONOCE study
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Kyowa Hakko Bio Company, Fundación ECO para la Excelencia y Calidad en la Oncología, López López, R., Camps Herrero, C., Khosravi-Shahi, P., Guillem Porta, V., Carrato Mena, A., Garcia-Foncillas, J., Cruz, Juan Jesús, Gascón Vilaplana, P., Antón Torres, A., Diaz-Rubio, E., Feyjoo Saus, M., Aranda Aguilar, E., Kyowa Hakko Bio Company, Fundación ECO para la Excelencia y Calidad en la Oncología, López López, R., Camps Herrero, C., Khosravi-Shahi, P., Guillem Porta, V., Carrato Mena, A., Garcia-Foncillas, J., Cruz, Juan Jesús, Gascón Vilaplana, P., Antón Torres, A., Diaz-Rubio, E., Feyjoo Saus, M., and Aranda Aguilar, E.
- Abstract
[Purpose]: Breakthrough cancer pain (BTcP) has been shown to be a prevalent and poor prognostic factor for oncologic patients, which remain under diagnosed and undertreated. In 2012, the Spanish Society of Medical Oncology (SEOM) published a clinical practice guideline (CPG) for the treatment of cancer pain which specifically addressed the management of BTcP., [Methods]: Fundación ECO designed a qualitative study using an Internet-based survey to investigate the attitudes toward, compliance with, and use of SEOM Guideline., [Results]: A total of 83 oncologists with a mean experience of 13 years responded. Overall, 82% were aware of different guidelines to manage BTcP. Notably, attitudes toward guidelines were highly positive and there was nearly unanimous agreement that CPG provided the best scientific evidence available (99%), on the minimum information to be gathered for the medical history (100%), on the need for a specific treatment for BTcP (100%), and fentanyl as the first-choice drug (99%). Interestingly, there were discrepancies between what oncologists agreed with and what they do in clinical practice. In fact, 87.6% declare full compliance with SEOM guideline, although adherence to registration of BTcP data in medical records ranged from 30.1 to 91.6% (mean 64.5%); therapeutic management compliance was higher ranging from 75.9 to 91.6%. Main barriers identified were time pressure together with vague statements and limited dissemination of the guidelines., [Conclusion]: Despite oncologist’s clinical practice is increasingly guided by GPC, it suffers from limited compliance, at least in part due to suboptimal statements. Improved dissemination and education are needed to enhance guideline implementation.
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- 2018
32. Assessment and treatment of breakthrough cancer pain in Spain: A self-audit study
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Lopez Lopez, R., primary, Reina Zoilo, J.J., additional, Monge, D., additional, Caballero, F., additional, Guillem Porta, V., additional, Aranda Aguilar, E., additional, Carrato Mena, A., additional, Diaz Rubio, E., additional, Garcia Foncillas, J., additional, Feyjoo, M., additional, and Camps, C., additional
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- 2018
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33. The quality oncology practice initiative program: Experience in Spain
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Lopez Lopez, R., primary, Anton Torres, A., additional, Aranda Aguilar, E., additional, Carrato Mena, A., additional, Constenla Figueiras, M., additional, Cruz Hernandez, J.J., additional, Diaz Rubio, E., additional, Feyjoo, M., additional, Garcia Foncillas, J., additional, Gascon, P.N., additional, Guillem Porta, V., additional, Lugo Cuan, I.S., additional, Rogado, A., additional, and Camps, C., additional
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- 2018
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34. Clinical practice evaluation of opioids induced constipation management in oncologic patients: The EIO-50 project
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Salvador Bofill, J., primary, Guillem Porta, V., additional, Feyjoo, M., additional, Anton Torres, A., additional, Aranda Aguilar, E., additional, Camps, C., additional, Carrato Mena, A., additional, Constenla Figueiras, M., additional, Cruz Hernandez, J.J., additional, Diaz Rubio, E., additional, Garcia Foncillas, J., additional, Gascon, P.N., additional, Lopez Lopez, R., additional, Soler, B., additional, and Escobar, Y., additional
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- 2018
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35. Active study: undetected prevalence and clinical inertia in the treatment of breakthrough cancer pain (BTcP)
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Camps Herrero, C., primary, Reina Zoilo, J. J., additional, Monge Martín, D., additional, Caballero Martínez, F., additional, Guillem Porta, V., additional, Aranda Aguilar, E., additional, Carrato Mena, A., additional, Díaz-Rubio García, E., additional, García-Foncillas López, J., additional, Feijóo Saus, M., additional, and López López, R., additional
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- 2018
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36. Crítica de Libros
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Gaspar, E. Marcuello and Porta, V. Guillem
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- 2000
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37. Abstracts of the Poster Sessions
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Brack, C., Beyer, P., Dinkelacker, G., Müller, H. P., Ball, P., Knuppen, R., Sack, J., Blum, M., Raker, Z., Tulchinsky, T., Gutekunst, R., Akstein, A., Albisu, M., Potau, N., Maya, A., Gussiner, M., Vicens-Calvet, E., Vaandrager, G. J., Wilma, T., Gons, M. H., Vijlder, J. J. M., Vulsma, T., Colon, C., Alonso-Fernandez, J. R., Castineiras, D. E., Romero, M. E., Fraga, J. M., Pena, J., Ackermann, G., Ackernmsnn, W., Willgerodt, H., Fiebig, H., Thiele, H. J., Morissette, J., Bélanger, N., Fiset, P., Dussault, J. H., Laberge, C., Fukushi, M., Arai, O., Mitzushima, Y., Takasugi, N., Eàndo, M., Matsuura, N., Fujimoto, S., Sinha, A. K., Al-Mazidi, A., Elvira, M. C. Ruiz, Brook, C. G. D., Ekins, R. P., Rubinstein, M., Jeghers, O., Mathur, R., Maerschalk, C., Errons, A. M., Gruters, A., Bogner, U., Schleusener, H., Helge, H., Hsiao, K. J., Shieh, M. J., Chiang, S. H., Su, F. Y., Chiovato, L., Giusti, F. L., Santini, F., Bassi, P., Vitti, P., Marcocci, C., Tonacchera, M., Ciampi, M., Fenzi, G. F., Pinchera, A., Brown, R. S., Keating, P., Mitchell, E., Ilirki, A., Larsson, A., Karlssan, F. A., Capiau, H., Roelen, L., Clara, R., Addison, G. M., Rosenthal, M., Price, D. A., Sorcini, M. Carta, Carta, S., Diodato, A., Fazzini, C., Grandolfo, M. E., Donati, L., Romagnoli, C., Luciano, R., Bourdoux, P., Delange, F., Mengreli, C., Pantelakis, S., Swennen, B., Vanderpas, J., Abeele, P., Gillies, J., Thilly, C., Schepper, J., Wolf, D., Smits, L., Chanoine, J. P., Steppe, M., Bergmann, P., Biarent, D., Delaet, M. H., Bouton, J. M., Hayashi, M., Shimohira, M., Saisho, S., Suzuki, H., Shimozawa, K., Iwakawa, Y., Bellisario, R., Freligh, L. J., Wiley, A. M., Cower, M. L., Pandian, M. R., Bruyn, R., Grant, D. B., Eldar, D., Amado, O., Péter, F., Blatniczky, L., Breyer, H., Ng, W. K., Leung, S. P., Hulse, J. A., Bovet, J., Ehrlich, R., Sorbara, D., Rickards, A., Coakley, J., Francis, I., Armstrong, S., Medson, H., Connelly, J., Fuggle, P., Murphy, G., Thorley, G., Toublanc, J. E., Rives, S., Job, J. C., Ibanez, L., Group, Catalan Collaborative, Rondanini, G. F., Bollati, A., Porta, V. Della, Cerabolini, R., Lenti, C., Rovey, L., Manzoni, A., Chiumello, G., Bargagna, S., Cittadoni, L., Falciglia, G., Ferretti, G., Marcheschi, M., Giovato, L., Sorhara, D., Delange, François, editor, Fisher, Delbert A., editor, and Glinoer, Daniel, editor
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- 1989
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38. Oncologist’s knowledge and implementation of guidelines for breakthrough cancer pain in Spain: CONOCE study
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López López, R., primary, Camps Herrero, C., additional, Khosravi-Shahi, P., additional, Guillem Porta, V., additional, Carrato Mena, A., additional, Garcia-Foncillas, J., additional, Cruz Hernández, J. J., additional, Gascón Vilaplana, P., additional, Antón Torres, A., additional, Diaz-Rubio, E., additional, Feyjoo Saus, M., additional, and Aranda Aguilar, E., additional
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- 2017
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39. How do Spanish medical oncologists manage breakthrough pain? A national study
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Aranda, E., primary, Camps Herrero, C., additional, Khosravi, P., additional, Feyjoo, M., additional, Anton Torres, A., additional, Gascon, P., additional, Garcia Foncillas, J., additional, Diaz Rubio, E., additional, Guillem Porta, V., additional, Carrato, A., additional, Constenla Figueiras, M., additional, Cruz Hernandez, J.J., additional, and López, R., additional
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- 2017
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40. 1819P - Clinical practice evaluation of opioids induced constipation management in cancer patients: The EIO-Praxis project
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Aranda Aguilar, E., Garcia Foncillas, J., Antón, A., Camps Herrero, C.J., Carrato Mena, A., Constenla Figueiras, M., Cruz Hernandez, J.J., Diaz Rubio, E., Gascon, P.N., Guillem Porta, V., López, R., Feyjóo, M., and Puente, J.
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- 2019
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41. A prognostic index for locoregional recurrence after neoadjuvant chemotherapy
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Herrero-Vicent, C, primary, Guerrero-Zotano, A, additional, Gavilá-Gregori, J, additional, Hernández-Blanquisett, A, additional, Sandiego-Contreras, S, additional, Samper-Hiraldo, JM, additional, Guillem-Porta, V, additional, and Ruiz-Simón, A, additional
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- 2016
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42. 1709P - Assessment and treatment of breakthrough cancer pain in Spain: A self-audit study
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Lopez Lopez, R., Reina Zoilo, J.J., Monge, D., Caballero, F., Guillem Porta, V., Aranda Aguilar, E., Carrato Mena, A., Diaz Rubio, E., Garcia Foncillas, J., Feyjoo, M., and Camps, C.
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- 2018
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43. 1710P - Clinical practice evaluation of opioids induced constipation management in oncologic patients: The EIO-50 project
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Salvador Bofill, J., Guillem Porta, V., Feyjoo, M., Anton Torres, A., Aranda Aguilar, E., Camps, C., Carrato Mena, A., Constenla Figueiras, M., Cruz Hernandez, J.J., Diaz Rubio, E., Garcia Foncillas, J., Gascon, P.N., Lopez Lopez, R., Soler, B., and Escobar, Y.
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- 2018
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44. 1586P - The quality oncology practice initiative program: Experience in Spain
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Lopez Lopez, R., Anton Torres, A., Aranda Aguilar, E., Carrato Mena, A., Constenla Figueiras, M., Cruz Hernandez, J.J., Diaz Rubio, E., Feyjoo, M., Garcia Foncillas, J., Gascon, P.N., Guillem Porta, V., Lugo Cuan, I.S., Rogado, A., and Camps, C.
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- 2018
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45. Aliphatic monoamines, diamines, polyamines: An HPLC method for their identification and separation by a dansylation reaction; The study of separation factors in homologous series
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Gennaro, M. C., Mentasti, E., Sarzanini, C., and Porta, V.
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- 1988
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46. Phase II trial with letrozole to maximum response as primary systemic therapy in postmenopausal patients with ER/PgR[ plus ] operable breast cancer
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Llombart-Cussac A, Guerrero A, Galan A, Caranana V, Buch E, Rodriguez-Lescure A, Ruiz A, Diana C, and Porta V
- Abstract
Purpose Letrozole is superior to tamoxifen in terms of response and breast preservation rates as primary systemic therapy (PST) in postmenopausal women with ER-positive early breast cancer. However, the optimum duration of endocrine PST remains uncertain. Methods A phase 2 multicentre, open-label trial was conducted to evaluate the efficacy of letrozole over a preoperative period of 4 months to 1 year. Seventy postmenopausal patients (over 65 years) were recruited in four centers. The primary endpoint was to establish the optimal duration of treatment defined as the time required to attain the maximum response by clinical palpation. Results The median age of the group was 79 years (66-91) and the median tumour size 35 mm (range 25-100 mm). No severe adverse events were reported. Fifty-six patients were evaluable for the primary objective. A total of 43 patients (76.8%) achieved an objective response; 29 (51.8%) being partial and 14 (25.0%) complete. The median time to objective response was 3.9 months (95% CI, 3.3-4.5) and the median time to maximum response was 4.2 months (95% CI, 4.0-4.5), although 20 (37.1%) patients achieved the maximal response within 6-12 months. Conclusions Letrozole shows a high activity and excellent tolerability as neoadjuvant therapy in elderly patients with endocrine-dependent breast cancer. Four to six months of letrozole as PST is an optimum duration with modest benefits thereafter.
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- 2012
47. CONFRONTO TRA TIPI DI FAVA LARGA DI LEONFORTE
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Branca, Ferdinando, LA PORTA, V, Palmigiano, S, and Chiarenza, G. L.
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- 2010
48. Introduzione di specie spontanee arbustivi in ambienti marginaliper ampliare la biodiversità vegetale:il caso di Spartium junceum L
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LA PORTA, V, Branca, Ferdinando, and Chiarenza, G. L.
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- 2010
49. 1587P - How do Spanish medical oncologists manage breakthrough pain? A national study
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Aranda, E., Camps Herrero, C., Khosravi, P., Feyjoo, M., Anton Torres, A., Gascon, P., Garcia Foncillas, J., Diaz Rubio, E., Guillem Porta, V., Carrato, A., Constenla Figueiras, M., Cruz Hernandez, J.J., and López, R.
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- 2017
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50. A case of septic shock secondary to Corynebacterium aquaticum bacteremia occurring in an HIV-infected patient attending a promiscuous thermal SPA
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Corona, A., Castelli, A., Ballone, E., Rech, R., Riccardo Colombo, Ferraris, S., Della Porta, V., and Raimondi, F.
- Subjects
Adult ,Male ,Corynebacterium Infections ,Balneology ,Risk Factors ,Humans ,Bacteremia ,HIV Infections ,Shock, Septic - Abstract
Corynebacterium aquaticum, an environmental organism associated with fresh water, has very seldom proved to be a cause of infection, although it has increasingly been isolated from clinical specimens. This report describes an unusual case of bacteremia occurring in an HIV-infected patient, complicated by septic shock and secondary to an epididimo-orchitis. Combination therapy of levofloxacin and metronidazole was used successfully.
- Published
- 2007
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