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8. Postbariatric hypoglycemia: symptom patterns and associated risk factors in the Longitudinal Assessment of Bariatric Surgery study

Author

Berk, Paul D., Bessler, Marc, Daud, Amna, Lobdell, Harrison, IV, Mwelu, Jemela, Schrope, Beth, Ude, Akuezunkpa, Honohan, Jamie, Capasso, Michelle, Costa, Ricardo, Dakin, Greg, Ebel, Faith, Gagner, Michel, Hsieh, Jane, Pomp, Alfons, Strain, Gladys, Bowden, Rita, Chapman, William, Cundiff, Blair, Ball, Mallory, Cunningham, Emily, Dohm, Lynis, Pender, John, Pories, Walter, Barker, Jennifer, Howell, Michael, Garcia, Luis, Lancaster, Kathy, Lovaas, Erika, Mitchell, James E., Monson, Tim, Cassady, Chelsea, Coburn, Emily, Moher, Emily, Deveney, Clifford, Elder, Katherine, Greene, Stefanie, Purnell, Jonathan, O’Rourke, Robert, Sorenson, Chad, Wolfe, Bruce M., Patterson, Emma, Raum, William, VanDerWerff, Lisa, Kwiatkowski, Jason, Courcoulas, Anita P., Gourash, William, McCloskey, Carol A., Ramanathan, Ramesh, Kalarchian, Melissa, Marcus, Marsha, Shirley, Eleanor, Turo, Angela, Flum, David R., Dellinger, E. Patchen, Khandelwal, Saurabh, Stewart, Skye D., Cooley, Morgan M., Blissell, Rebecca, Miller, Megan J., Thirlby, Richard, Chang, Lily, Hunter, Jeffrey, Moonka, Ravi, Ng, Debbie, Belle, Steven H., King, Wendy C., Martin, Debbie, Mercurio, Rocco, Wahed, Abdus, Averbach, Frani, Horlick, Mary, Miles, Carolyn W., Staten, Myrlene A., Yanovski, Susan Z., Kleiner, David E., Fischer, Laura E., Fino, Nora, Elman, Miriam R., Pories, Walter J., Purnell, Jonathan Q., and Patti, Mary-Elizabeth

Published
2021
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11. Effects of Weight Loss and Weight Maintenance on Lipoprotein Insulin Resistance Scores in Adults with Overweight and Obesity.

Author

Grammer, Emily E., McGee, Joshua E., Bartlett, Allison N., Brown, Taylor T., Clunan, Marie C., Huff, Anna C., Osborne, Briceida G., Matarese, Laura E., Pories, Walter J., Houmard, Joseph A., Carels, Robert A., Sarzynski, Mark A., and Swift, Damon L.

Abstract

Background: An elevated lipoprotein insulin resistance (LP-IR) score corresponds to insulin resistance in adults with overweight and obesity, yet data are lacking regarding the impact of exercise interventions on LP-IR. The purpose of this secondary analysis was to evaluate the effects of a weight loss and weight maintenance intervention on LP-IR score in adults with overweight and obesity. Methods: Thirty sedentary adults with overweight and obesity completed a 10-week OPTIFAST® weight loss program with supervised aerobic exercise to achieve clinical weight loss (CWL) (≥7% from baseline). Aerobic exercise volume increased weekly until 700 MET min/week was reached. Participants who reached CWL were randomized to groups at volumes at either physical activity (PA-REC) or weight maintenance (WM-REC) recommendations (weeks 11–28). Plasma blood samples were analyzed via nuclear magnetic resonance spectroscopy at baseline, after weight loss (week 10), and following weight maintenance (week 28). Results: Following the weight loss phase, on average, participants significantly (p < 0.001) reduced LP-IR score (−12.1 ± 13.5), body weight (−8.9 ± 2.7%), and waist circumference (−7.7 ± 4.1 cm). During the weight maintenance phase, there were no changes in LP-IR score between exercise groups (PA-REC: 4.1 ± 13.6; WM-REC: −2.0 ± 11.2; P = 0.7). The PA-REC group had improvements in LP-IR score from baseline (49.8 ± 24.6 to 36.6 ± 27.6, P < 0.001), yet there were no within-group changes during the weight maintenance phase (P > 0.05). Conclusion: LP-IR score improved during weight loss in adults with overweight and obesity and were sustained during the weight maintenance phase in the PA-REC group. Aerobic exercise at least at minimum guidelines following CWL can preserve LP-IR score improvements and may indicate a reduced T2DM risk in adults with overweight and obesity. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Urinary Incontinence Before and After Bariatric Surgery

Author

Subak, Leslee L, King, Wendy C, Belle, Steven H, Chen, Jia-Yuh, Courcoulas, Anita P, Ebel, Faith E, Flum, David R, Khandelwal, Saurabh, Pender, John R, Pierson, Sheila K, Pories, Walter J, Steffen, Kristine J, Strain, Gladys W, Wolfe, Bruce M, and Huang, Alison J

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Prevention, Nutrition, Obesity, Urologic Diseases, Clinical Research, Clinical Trials and Supportive Activities, Oral and gastrointestinal, Renal and urogenital, Adolescent, Adult, Age Factors, Aged, Bariatric Surgery, Body Mass Index, Cohort Studies, Comorbidity, Female, Humans, Longitudinal Studies, Male, Middle Aged, Obesity, Morbid, Prevalence, Treatment Outcome, Urinary Incontinence, Stress, Urinary Incontinence, Urge, Weight Loss, Young Adult, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Clinical sciences, Health services and systems
Abstract

ImportanceAmong women and men with severe obesity, evidence for improvement in urinary incontinence beyond the first year after bariatric surgery-induced weight loss is lacking.ObjectivesTo examine change in urinary incontinence before and after bariatric surgery and to identify factors associated with improvement and remission among women and men in the first 3 years after bariatric surgery.Design, setting, and participantsThe Longitudinal Assessment of Bariatric Surgery 2 is an observational cohort study at 10 US hospitals in 6 geographically diverse clinical centers. Participants were recruited between February 21, 2005, and February 17, 2009. Adults undergoing first-time bariatric surgical procedures as part of clinical care by participating surgeons between March 14, 2006, and April 24, 2009, were followed up for 3 years (through October 24, 2012).InterventionParticipants undergoing bariatric surgery completed research assessments before the procedure and annually thereafter.Main outcomes and measuresThe frequency and type of urinary incontinence episodes in the past 3 months were assessed using a validated questionnaire. Prevalent urinary incontinence was defined as at least weekly urinary incontinence episodes, and remission was defined as change from prevalent urinary incontinence at baseline to less than weekly urinary incontinence episodes at follow-up.ResultsOf 2458 participants, 1987 (80.8%) completed baseline and follow-up assessments. At baseline, the median age was 47 years (age range, 18-78 years), the median body mass index was 46 kg/m2 (range, 34-94 kg/m2), and 1565 of 1987 (78.8%) were women. Urinary incontinence was more prevalent among women (49.3%; 95% CI, 46.9%-51.9%) than men (21.8%; 95% CI, 18.2%-26.1%) (P

Published
2015

22. Disparities in Access to Bariatric Surgery in North Carolina

Author

Wong, Jan H., Burch, Ashley E., DeMaria, Eric J., Pories, Walter J., and Irish, William D.

Abstract

Background This study sought to identify factors that contribute to disparities in access to bariatric surgery in North Carolina (NC).Methods Using the rate of bariatric surgery in the county with the best health outcome as the reference, we calculated the Surgical Equity Index (SEI) in the remaining counties in NC.Results Approximately 2.95 million individuals (29%) were obese in NC. There were 992 (.5%) bariatric procedures performed on a population of 194 209 individuals with obesity in the Reference County (RC). The mean SEI for bariatric surgery in NC was .47 (SD .17, range .15-.95). A statistically significant difference was observed in 89 counties. Univariable analyses identified the following variables to be significantly associated with the SEI: percent of population living in rural areas (% rural) (relative rate change in SEI [RR] = .994, 95% CI .92-.997; <.0001), median household income (RR = 1.0, 95% CI = 1.0-1.0; P= .0002), prevalence of diabetes (RR = .947, 95% CI .917-.977; .0006), the primary care physician ratio (RR = .995, 95% CI .991-.998; P= .006), and percent uninsured adults (RR = .955, 95% CI .927-.985; P= .003). By multivariable hierarchical regression analysis, only the % rural remained statistically associated with a low SEI (RR = .995 per 1% increase in % rural, 95% CI = .992, .998; P= .0002).Discussion The percent rural is the most significant predictor of disparities in access to bariatric surgery. For every 1% increase in % rural, the rate of surgery decreased by .5%. Understanding the characteristics of rurality that are barriers to access is crucial to mitigate disparities in bariatric surgical access in NC.

Published
2024
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28. Effects Of Weight Loss And Maintenance On Apolipoprotein B In Overweight And Obese Adults

Author

Grammer, Emily E., primary, McGee, Joshua E., additional, Brown, Taylor T., additional, Clunan, Marie C., additional, Huff, Anna C., additional, Osborne, Briceida G., additional, Matarese, Laura E., additional, Pories, Walter J., additional, Houmard, Joseph A., additional, Carels, Robert A., additional, Sarzynski, Mark A., additional, and Swift, Damon L., additional

Published
2023
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29. Effects Of Weight Loss And Weight Maintenance On Inflammation In Overweight And Obese Adults

Author

Stahl, Macy E., primary, Grammer, Emily E., additional, McGee, Joshua E., additional, Brown, Taylor T., additional, Clunan, Marie C., additional, Huff, Anna C., additional, Osborne, Briceida G., additional, Matarese, Laura E., additional, Pories, Walter J., additional, Houmard, Joseph A., additional, Carels, Robert A., additional, Sarzynski, Mark A., additional, and Swift, Damon L., additional

Published
2023
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34. Greater Reliance on Glycolysis is Associated with Lower Mitochondrial Substrate Oxidation and Insulin Sensitivity in Infant Myogenic MSCs

Author

Jevtovic, Filip, primary, Zheng, Donghai, additional, Lopez, Christian A, additional, Kern, Kara, additional, Tanner, Charles J., additional, Jones, Terry E., additional, Pories, Walter J., additional, Dohm, G. Lynis, additional, Houmard, Joseph A, additional, May, Linda E, additional, and Broskey, Nicholas T, additional

Published
2023
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41. The Rationale for Metabolic Surgery

Author

Pories, Walter J., Buchwald, Henry, Nguyen, Ninh T., editor, Blackstone, Robin P., editor, Morton, John M., editor, Ponce, Jaime, editor, and Rosenthal, Raul J., editor

Published
2015
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46. Effects of weight loss and weight loss maintenance on cardiac autonomic function in obesity: a randomized controlled trial

Author

McGee, Joshua Eric, primary, Early, Kate, additional, Huff, Anna Caroline, additional, Clunan, Marie Covey, additional, Hursey, Nicole Renee, additional, Osborne, Briceida, additional, Bucher, Colleen, additional, Tanner, Charles J, additional, Brewer, Savanna Barefoot, additional, Brophy, Patricia, additional, Clark, Angela, additional, Pories, Walter J, additional, Matarese, Laura E, additional, Houmard, Joseph A., additional, Collier, David, additional, May, Linda E, additional, McClung, Joseph M, additional, Earnest, Conrad P., additional, and Swift, Damon L, additional

Published
2023
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