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6. High expression of Mcl-1 in ALK positive and negative anaplastic large cell lymphoma

Author

Rust, R, Harms, G, Blokzijl, T, Boot, M, Diepstra, A, Kluiver, J, Visser, J, Peh, S-C, Lim, M, Kamps, W A, Poppema, S, and van der Berg, A

Subjects
Tumors in children -- Diagnosis, Tumors in children -- Care and treatment, Tumors in children -- Research, Lymphomas -- Diagnosis, Lymphomas -- Care and treatment, Lymphomas -- Research, Gene expression -- Research, Gene expression -- Comparative analysis, Health
Published
2005

28. The Typical Reed-Sternberg Phenotype and I g Gene Rearrangement of Hodgkin’s Disease Derived Cell Line ZO Indicating a B-Cell Origin

Author

Poppema, S., Visser, L., de Jong, B., Brinker, M., Atmosoerodjo, J., Timens, W., Herfarth, Ch., editor, Senn, H.-J., editor, Baum, M., editor, Diehl, V., editor, Grundmann, E., editor, Gutzwiller, F., editor, Hitzig, W., editor, Rajewsky, M. F., editor, Wannenmacher, M., editor, Diehl, Volker, editor, Pfreundschuh, Michael, editor, and Loeffler, Markus, editor

Published
1989
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29. Expression and Characterization of Leucocyte Antigens

Author

Allen, R., Ferrone, S., Hoch, J., Bankhurst, A., Spellmann, J., Burmester, G. R., Dimitriu-Bona, A., Gregersen, P., Waters, S. J., Winchester, R. J., Burrone, O. R., Calabi, F., Gilmore, D., Wright, B., Milstein, C., Clark, E., Martin, P., Hansen, J., Ledbetter, J., de Leij, L., Poppema, S., The, T. H., De Vries, J. E., Vaessen, R., Janssens, P., Tan, B., Heiman, A., Figdor, C. G., Dörken, B., Pfreundschuh, M., Moldenhauer, G., Schwarz, E., Hämmerling, G., Frisman, D., Baird, S., Gazit, E., Gothelf, Y., Gil, R., Orgad, S., Yunis, E. J., Girardet, Ch., Heumann, D., Mach, J.-P., von Fliedner, V., Carrel, S., Goyert, S. M., Silver, J., Hogg, N., Hokland, P., Schlossman, S. F., Ritz, J., Kalil, J., Abita, J. P., Chomienne, C., Poirier, O., Besluau, D., Dastot, H., Reboul, M., Fellous, M., Colombani, J., Kater, L., Brekelmans, P., Daemen, T., Schuurman, H. J., Katz, F., Povey, S., Stanley, K., Schneider, C., Greaves, M., Lemonnier, F. A., Le Bouteiller, P. P., Malissen, B., Golstein, P., Malissen, M., Mishal, Z., Caillol, D. H., Jordan, B. R., Kourilsky, F., Lennert, K., Stein, H., Miiller-Hermelink, H. K., Vollenweider, R., Karol, R. A., Eng, J., Dennison, D., Faris, E., Marcus, D. M., Piatier-Tonneau, D., Boyer, B., Debre, P., Charron, D., Reuben, J. M., Hersh, E. M., Mansell, P. W. A., Newell, G., Rios, A., Rumpold, H., Kraft, D., Förster, O., Schulz, T. F., Alsenz, J., Scheiner, O., Lambris, J., Dierich, M. P., Van Laarhoven, J. P. R. M., Broekhuizen, R., Spierenburg, G. Th., De Bruyn, C. H. M. M., Solbach, W., Röllinghoff, M., Wagner, H., Szer, I. S., Irani, A., Tax, W. J. M., Janossy, G., Jonker, M., Willems, R., Leeuwenberg, J., Capel, P. J. A., Koene, R. A. P., Leeuwenberg, H. F. M., Willems, H. M., Tetteroo, P. A. T., Visser, F., Landsdorp, P., von dem Borne, A. E. G. Kr., Thompson, J. S., Goeken, N. E., Brown, S. A., Rhoades, J. R., Yamamoto, K., Nakauchi, H., Karasuyama, H., Kitamura, K., Tanimoto, K., Okumura, K., Bernard, Alain, editor, Boumsell, Laurence, editor, Dausset, Jean, editor, Milstein, César, editor, and Schlossman, Stuart F., editor

Published
1984
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37. Multiple HLA class I and II associations in classical Hodgkin lymphoma and EBV status defined subgroups (Retraction of vol 118, pg 5211, 2011)

Author

Huang, X., Kushekhar, K., Nolte, Roeland J. M., Kooistra, W., Visser, Lydia, Bouwman, Ilby, Kouprie, N., Veenstra, R., van Imhoff, G., Imhoff, G., Olver, B., Houlston, R. S., Poppema, S., Diepstra, A., Hepkema, B., van den Berg, A., Stem Cell Aging Leukemia and Lymphoma (SALL), and Damage and Repair in Cancer Development and Cancer Treatment (DARE)

Published
2012

41. THE ROLE OF MIRNAS IN HODGKIN LYMPHOMA

Author

Den Berg, A., Tan, Ping L., Gibcus, J., Joost Kluiver, Slezack-Prochzka, I., Halsema, N., Jong, D., Kroesen, B-J, and Poppema, S.

Published
2010

47. TIMP-I expression in anaplastic large cell lymphoma is usually restricted to macrophages and only seldom observed in tumour cells

Author

Rust, R, Blokzijl, T, Harms, G, Lim, M, Visser, L, Kamps, WA, Poppema, S, van den Berg, Anke, Stem Cell Aging Leukemia and Lymphoma (SALL), and Translational Immunology Groningen (TRIGR)

Subjects
MMP-2, MATRIX METALLOPROTEINASES, NON-HODGKINS-LYMPHOMAS, macrophage, KI-1 LYMPHOMA, INTERLEUKIN-10, ALCL, ANGIOGENESIS, TIMP-1, TISSUE INHIBITOR, hemic and lymphatic diseases, METASTASIS, GROWTH, SIGNAL TRANSDUCER, TRANSCRIPTION-3
Abstract

Anaplastic large cell lymphomas (ALCLs) can be subdivided into two subgroups on the basis of their expression of the ALK protein. ALK protein expression leads to activation of signal transducer and activator of transcription (STAT) 3, which is more commonly expressed in ALK-positive than in ALK-negative tumours. Activated STAT3 leads to the induction of several genes such as Mcl-1, Bcl-2 and Bcl-X-L, and tissue inhibitor of metalloproteinase (TIMP)-1. In this study, we analysed TIMP-1 expression in five ALCL cell lines and 11 tumours by quantitative RT-PCR and immunohistochemistry. We identified high-level TIMP-1 expression by RT-PCR in three ALK-positive ALCL-derived cell lines and in all ALK-positive ALCLs, whereas ALK-negative ALCLs generally demonstrated a lower level of TIMP-1 expression. Concordant with these results, we observed TIMP-1 immunostaining in all ALK-positive ALCLs and in only two of six ALK-negative ALCLs. No relationship was observed between the levels of ALK and TIMP-1 expression in the ALK-positive tumours. STAT3 expression levels were similar in all ALCL samples. Double staining with either CD30 or CD68 demonstrated that TIMP-1 expression was restricted to macrophages in the majority of TIMP-1-positive tumours. Expression of the TIMP-1 substrate MMP-2 was more prominent in ALK-negative tumours, while MMP-9 levels were low in all cases. Expression levels of IL-6 and TGF-beta 1, which are cytokines known to induce TIMP-1 were higher in ALK-negative ALCLs and moderate in ALK-positive tumours. No clear relationship was observed between IL-10 expression and ALK positivity. Overall, no correlation was seen in ALCLs between the expression of TIMP-1 and that of cytokines that induce TIMP-1. Lack of TIMP-I expression in the tumour cells of ALK-positive ALCLs argues against a direct role for ALK-induced activation of STAT3 in the regulation of TIMP-1 expression in ALCL. Copyright (c) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Published
2005

48. Shedding of L-selectin as induced by anti-CD45RB does not involve TACE/ADAM17

Author

Visser, L, Poppema, S, and Stem Cell Aging Leukemia and Lymphoma (SALL)

Subjects
MICE, REJECTION, ANTIBODY, CELLS, CD45RB
Abstract

Downregulation of CD45RB and L-selectin by anti-CD45RB antibody treatment may play an important role in the mechanism of action these antibodies in transplantation and autoimmune animal models. We found that the metalloprotease TACE/ADAM17 is not involved. Therefore, anti-CD45RB may activate another protease to cause the shedding of L-selectin and possibly also CD45RB.

Published
2004

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