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1. Results of the COVID-19 mental health international for the health professionals (COMET-HP) study: depression, suicidal tendencies and conspiracism

Author

N. Fountoulakis, Konstantinos, N. Karakatsoulis, Grigorios, Abraham, Seri, Adorjan, Kristina, Ahmed, Helal Uddin, Alarcón, Renato D., Arai, Kiyomi, Auwal, Sani Salihu, Bobes, Julio, Bobes-Bascaran, Teresa, Bourgin-Duchesnay, Julie, Bredicean, Cristina Ana, Bukelskis, Laurynas, Burkadze, Akaki, Cabrera Abud, Indira Indiana, Castilla-Puentes, Ruby, Cetkovich, Marcelo, Colon-Rivera, Hector, Corral, Ricardo, Cortez-Vergara, Carla, Crepin, Piirika, de Berardis, Domenico, Zamora Delgado, Sergio, de Lucena, David, de Sousa, Avinash, di Stefano, Ramona, Dodd, Seetal, Elek, Livia Priyanka, Elissa, Anna, Erdelyi-Hamza, Berta, Erzin, Gamze, Etchevers, Martin J., Falkai, Peter, Farcas, Adriana, Fedotov, Ilya, Filatova, Viktoriia, Fountoulakis, Nikolaos K., Frankova, Iryna, Franza, Francesco, Frias, Pedro, Galako, Tatiana, Garay, Cristian J., Garcia-Álvarez, Leticia, García-Portilla, Paz, Gonda, Xenia, Gondek, Tomasz M., Morera González, Daniela, Gould, Hilary, Grandinetti, Paolo, Grau, Arturo, Groudeva, Violeta, Hagin, Michal, Harada, Takayuki, Hasan, Tasdik M., Azreen Hashim, Nurul, Hilbig, Jan, Hossain, Sahadat, Iakimova, Rossitza, Ibrahim, Mona, Iftene, Felicia, Ignatenko, Yulia, Irarrazaval, Matias, Ismail, Zaliha, Ismayilova, Jamila, Jacobs, Asaf, Jakovljević, Miro, Jakšić, Nenad, Javed, Afzal, Yilmaz Kafali, Helin, Karia, Sagar, Kazakova, Olga, Khalifa, Doaa, Khaustova, Olena, Koh, Steve, Kopishinskaia, Svetlana, Kosenko, Korneliia, Koupidis, Sotirios A., Kovacs, Illes, Kulig, Barbara, Lalljee, Alisha, Liewig, Justine, Majid, Abdul, Malashonkova, Evgeniia, Malik, Khamelia, Iqbal Malik, Najma, Mammadzada, Gulay, Mandalia, Bilvesh, Marazziti, Donatella, Marčinko, Darko, Martinez, Stephanie, Matiekus, Eimantas, Mejia, Gabriela, Memon, Roha Saeed, Meza Martínez, Xarah Elenne, Mickevičiūtė, Dalia, Milev, Roumen, Mohammed, Muftau, Molina-López, Alejandro, Morozov, Petr, Muhammad, Nuru Suleiman, Mustač, Filip, Naor, Mika S., Nassieb, Amira, Navickas, Alvydas, Okasha, Tarek, Pandova, Milena, Panfil, Anca-Livia, Panteleeva, Liliya, Papava, Ion, Patsali, Mikaella E., Pavlichenko, Alexey, Pejuskovic, Bojana, Pinto da Costa, Mariana, Popkov, Mikhail, Popovic, Dina, Raduan, Nor Jannah Nasution, Vargas Ramírez, Francisca, Rancans, Elmars, Razali, Salmi, Rebok, Federico, Rewekant, Anna, Reyes Flores, Elena Ninoska, Rivera-Encinas, María Teresa, Saiz, Pilar A., Sánchez de Carmona, Manuel, Saucedo Martínez, David, Saw, Jo Anne, Saygili, Görkem, Schneidereit, Patricia, Shah, Bhumika, Shirasaka, Tomohiro, Silagadze, Ketevan, Sitanggang, Satti, Skugarevsky, Oleg, Spikina, Anna, Mahalingappa, Sridevi Sira, Stoyanova, Maria, Szczegielniak, Anna, Tamasan, Simona Claudia, Tavormina, Giuseppe, Tavormina, Maurilio Giuseppe Maria, Theodorakis, Pavlos N., Tohen, Mauricio, Tsapakis, Eva-Maria, Tukhvatullina, Dina, Ullah, Irfan, Vaidya, Ratnaraj, Vega-Dienstmaier, Johann M., Vrublevska, Jelena, Vukovic, Olivera, Vysotska, Olga, Widiasih, Natalia, Yashikhina, Anna, Prezerakos, Panagiotis E., Berk, Michael, Levaj, Sarah, and Smirnova, Daria

Published
2023
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2. Non-binary gender, vulnerable populations and mental health during the COVID-19 pandemic: Data from the COVID-19 MEntal health inTernational for the general population (COMET-G) study

Author

Fountoulakis, Konstantinos N., Vrublevska, Jelena, Abraham, Seri, Adorjan, Kristina, Ahmed, Helal Uddin, Alarcón, Renato D., Arai, Kiyomi, Auwal, Sani Salihu, Berk, Michael, Bjedov, Sarah, Bobes, Julio, Bobes-Bascaran, Teresa, Bourgin-Duchesnay, Julie, Bredicean, Cristina Ana, Bukelskis, Laurynas, Burkadze, Akaki, Abud, Indira Indiana Cabrera, Castilla-Puentes, Ruby, Cetkovich, Marcelo, Colon-Rivera, Hector, Corral, Ricardo, Cortez-Vergara, Carla, Crepin, Piirika, De Berardis, Domenico, Delgado, Sergio Zamora, De Lucena, David, De Sousa, Avinash, Di Stefano, Ramona, Dodd, Seetal, Elek, Livia Priyanka, Elissa, Anna, Erdelyi-Hamza, Berta, Erzin, Gamze, Etchevers, Martin J., Falkai, Peter, Farcas, Adriana, Fedotov, Ilya, Filatova, Viktoriia, Fountoulakis, Nikolaos K., Frankova, Iryna, Franza, Francesco, Frias, Pedro, Galako, Tatiana, Garay, Cristian J., Garcia-Álvarez, Leticia, García-Portilla, Maria Paz, Gonda, Xenia, Gondek, Tomasz M., González, Daniela Morera, Gould, Hilary, Grandinetti, Paolo, Grau, Arturo, Groudeva, Violeta, Hagin, Michal, Harada, Takayuki, Hasan, Tasdik M., Hashim, Nurul Azreen, Hilbig, Jan, Hossain, Sahadat, Iakimova, Rossitza, Ibrahim, Mona, Iftene, Felicia, Ignatenko, Yulia, Irarrazaval, Matias, Ismail, Zaliha, Ismayilova, Jamila, Jacobs, Asaf, Jakovljević, Miro, Jakšić, Nenad, Javed, Afzal, Kafali, Helin Yilmaz, Karia, Sagar, Kazakova, Olga, Khalifa, Doaa, Khaustova, Olena, Koh, Steve, Kosenko, Korneliia, Koupidis, Sotirios A., Lalljee, Alisha, Liewig, Justine, Majid, Abdul, Malashonkova, Evgeniia, Malik, Khamelia, Malik, Najma Iqbal, Mammadzada, Gulay, Mandalia, Bilvesh, Marazziti, Donatella, Marčinko, Darko, Martinez, Stephanie, Matiekus, Eimantas, Mejia, Gabriela, Memon, Roha Saeed, Martínez, Xarah Elenne Meza, Mickevičiūtė, Dalia, Milev, Roumen, Mohammed, Muftau, Molina-López, Alejandro, Morozov, Petr, Muhammad, Nuru Suleiman, Mustač, Filip, Naor, Mika S., Nassieb, Amira, Navickas, Alvydas, Okasha, Tarek, Pandova, Milena, Panfil, Anca-Livia, Panteleeva, Liliya, Papava, Ion, Patsali, Mikaella E., Pavlichenko, Alexey, Pejuskovic, Bojana, Da Costa, Mariana Pinto, Popkov, Mikhail, Popovic, Dina, Raduan, Nor Jannah Nasution, Ramírez, Francisca Vargas, Rancans, Elmars, Razali, Salmi, Rebok, Federico, Rewekant, Anna, Flores, Elena Ninoska Reyes, Rivera-Encinas, María Teresa, Saiz, Pilar, de Carmona, Manuel Sánchez, Martínez, David Saucedo, Saw, Jo Anne, Saygili, Görkem, Schneidereit, Patricia, Shah, Bhumika, Shirasaka, Tomohiro, Silagadze, Ketevan, Sitanggang, Satti, Skugarevsky, Oleg, Spikina, Anna, Mahalingappa, Sridevi Sira, Stoyanova, Maria, Szczegielniak, Anna, Tamasan, Simona Claudia, Tavormina, Giuseppe, Tavormina, Maurilio Giuseppe Maria, Theodorakis, Pavlos N., Tohen, Mauricio, Tsapakis, Eva Maria, Tukhvatullina, Dina, Ullah, Irfan, Vaidya, Ratnaraj, Vega-Dienstmaier, Johann M., Vukovic, Olivera, Vysotska, Olga, Widiasih, Natalia, Yashikhina, Anna, and Smirnova, Daria

Published
2024
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3. The effect of different degrees of lockdown and self-identified gender on anxiety, depression and suicidality during the COVID-19 pandemic: Data from the international COMET-G study.

Author

Fountoulakis, Konstantinos N., Karakatsoulis, Grigorios N., Abraham, Seri, Adorjan, Kristina, Ahmed, Helal Uddin, Alarcón, Renato D., Arai, Kiyomi, Auwal, Sani Salihu, Berk, Michael, Bjedov, Sarah, Bobes, Julio, Bobes-Bascaran, Teresa, Bourgin-Duchesnay, Julie, Bredicean, Cristina Ana, Bukelskis, Laurynas, Burkadze, Akaki, Abud, Indira Indiana Cabrera, Castilla-Puentes, Ruby, Cetkovich, Marcelo, Colon-Rivera, Hector, Corral, Ricardo, Cortez-Vergara, Carla, Crepin, Piirika, De Berardis, Domenico, Delgado, Sergio Zamora, De Lucena, David, De Sousa, Avinash, Stefano, Ramona Di, Dodd, Seetal, Elek, Livia Priyanka, Elissa, Anna, Erdelyi-Hamza, Berta, Erzin, Gamze, Etchevers, Martin J., Falkai, Peter, Farcas, Adriana, Fedotov, Ilya, Filatova, Viktoriia, Fountoulakis, Nikolaos K., Frankova, Iryna, Franza, Francesco, Frias, Pedro, Galako, Tatiana, Garay, Cristian J., Garcia-Álvarez, Leticia, García-Portilla, Maria Paz, Gonda, Xenia, Gondek, Tomasz M., González, Daniela Morera, Gould, Hilary, Grandinetti, Paolo, Grau, Arturo, Groudeva, Violeta, Hagin, Michal, Harada, Takayuki, Hasan, Tasdik M., Hashim, Nurul Azreen, Hilbig, Jan, Hossain, Sahadat, Iakimova, Rossitza, Ibrahim, Mona, Iftene, Felicia, Ignatenko, Yulia, Irarrazaval, Matias, Ismail, Zaliha, Ismayilova, Jamila, Jacobs, Asaf, Jakovljević, Miro, Jakšić, Nenad, Javed, Afzal, Kafali, Helin Yilmaz, Karia, Sagar, Kazakova, Olga, Khalifa, Doaa, Khaustova, Olena, Koh, Steve, Kopishinskaia, Svetlana, Kosenko, Korneliia, Koupidis, Sotirios A., Kovacs, Illes, Kulig, Barbara, Lalljee, Alisha, Liewig, Justine, Majid, Abdul, Malashonkova, Evgeniia, Malik, Khamelia, Malik, Najma Iqbal, Mammadzada, Gulay, Mandalia, Bilvesh, Marazziti, Donatella, Marčinko, Darko, Martinez, Stephanie, Matiekus, Eimantas, Mejia, Gabriela, Memon, Roha Saeed, Martínez, Xarah Elenne Meza, Mickevičiūtė, Dalia, Milev, Roumen, Mohammed, Muftau, Molina-López, Alejandro, Morozov, Petr, Muhammad, Nuru Suleiman, Mustač, Filip, Naor, Mika S., Nassieb, Amira, Navickas, Alvydas, Okasha, Tarek, Pandova, Milena, Panfil, Anca-Livia, Panteleeva, Liliya, Papava, Ion, Patsali, Mikaella E., Pavlichenko, Alexey, Pejuskovic, Bojana, Da Costa, Mariana Pinto, Popkov, Mikhail, Popovic, Dina, Raduan, Nor Jannah Nasution, Ramírez, Francisca Vargas, Rancans, Elmars, Razali, Salmi, Rebok, Federico, Rewekant, Anna, Flores, Elena Ninoska Reyes, Rivera-Encinas, María Teresa, Saiz, Pilar, de Carmona, Manuel Sánchez, Martínez, David Saucedo, Saw, Jo Anne, Saygili, Görkem, Schneidereit, Patricia, Shah, Bhumika, Shirasaka, Tomohiro, Silagadze, Ketevan, Sitanggang, Satti, Skugarevsky, Oleg, Spikina, Anna, Mahalingappa, Sridevi Sira, Stoyanova, Maria, Szczegielniak, Anna, Tamasan, Simona Claudia, Tavormina, Giuseppe, Tavormina, Maurilio Giuseppe Maria, Theodorakis, Pavlos N., Tohen, Mauricio, Tsapakis, Eva Maria, Tukhvatullina, Dina, Ullah, Irfan, Vaidya, Ratnaraj, Vega-Dienstmaier, Johann M., Vrublevska, Jelena, Vukovic, Olivera, Vysotska, Olga, Widiasih, Natalia, Yashikhina, Anna, Prezerakos, Panagiotis E., and Smirnova, Daria

Published
2022
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4. Expert consensus recommendations on the use of randomized clinical trials for drug approval in psychiatry- comparing trial designs

Author

Similon, Miriam von Mücke, Paasche, Cecilia, Krol, Fas, Lerer, Bernard, Goodwin, Guy M., Berk, Michael, Meyer-Lindenberg, Andreas, Ketter, Terence A., Yatham, Lakshmi N., Goldberg, Joseph F., Malhi, Gin S., El-Mallakh, Rif, Licht, Rasmus W., Young, Allan H., Kapczinski, Flavio, Swartz, Marnina, Hagin, Michal, Torrent, Carla, Serretti, Alessandro, Yildiz, Ayşegül, Martínez-Arán, Anabel, Strejilevich, Sergio, Rybakowski, Janusz, Sani, Gabriele, Grunze, Heinz, Vázquez, Gustavo, Pinto, Ana Gonzales, Azorin, Jean Michel, Nolen, Willem, Sentissi, Othman, López-Jaramillo, Carlos, Frey, Benicio N., Nierenberg, Andrew, Parker, Gordon, Bond, David J, Cohen, Adam, Tortorella, Alfonso, Perugi, Giulio, Vieta, Eduard, and Popovic, Dina

Published
2022
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5. Results of the COVID-19 mental health international for the general population (COMET-G) study

Author

Fountoulakis, Konstantinos N, Karakatsoulis, Grigorios, Abraham, Seri, Adorjan, Kristina, Ahmed, Helal Uddin, Alarcón, Renato D., Arai, Kiyomi, Auwal, Sani Salihu, Berk, Michael, Bjedov, Sarah, Bobes, Julio, Bobes-Bascaran, Teresa, Bourgin-Duchesnay, Julie, Bredicean, Cristina Ana, Bukelskis, Laurynas, Burkadze, Akaki, Abud, Indira Indiana Cabrera, Castilla-Puentes, Ruby, Cetkovich, Marcelo, Colon-Rivera, Hector, Corral, Ricardo, Cortez-Vergara, Carla, Crepin, Piirika, De Berardis, Domenico, Zamora Delgado, Sergio, De Lucena, David, De Sousa, Avinash, Stefano, Ramona Di, Dodd, Seetal, Elek, Livia Priyanka, Elissa, Anna, Erdelyi-Hamza, Berta, Erzin, Gamze, Etchevers, Martin J., Falkai, Peter, Farcas, Adriana, Fedotov, Ilya, Filatova, Viktoriia, Fountoulakis, Nikolaos K., Frankova, Iryna, Franza, Francesco, Frias, Pedro, Galako, Tatiana, Garay, Cristian J., Garcia-Álvarez, Leticia, García-Portilla, Maria Paz, Gonda, Xenia, Gondek, Tomasz M., González, Daniela Morera, Gould, Hilary, Grandinetti, Paolo, Grau, Arturo, Groudeva, Violeta, Hagin, Michal, Harada, Takayuki, Hasan, M. Tasdik, Hashim, Nurul Azreen, Hilbig, Jan, Hossain, Sahadat, Iakimova, Rossitza, Ibrahim, Mona, Iftene, Felicia, Ignatenko, Yulia, Irarrazaval, Matias, Ismail, Zaliha, Ismayilova, Jamila, Jacobs, Asaf, Jakovljević, Miro, Jakšić, Nenad, Javed, Afzal, Kafali, Helin Yilmaz, Karia, Sagar, Kazakova, Olga, Khalifa, Doaa, Khaustova, Olena, Koh, Steve, Kopishinskaia, Svetlana, Kosenko, Korneliia, Koupidis, Sotirios A., Kovacs, Illes, Kulig, Barbara, Lalljee, Alisha, Liewig, Justine, Majid, Abdul, Malashonkova, Evgeniia, Malik, Khamelia, Malik, Najma Iqbal, Mammadzada, Gulay, Mandalia, Bilvesh, Marazziti, Donatella, Marčinko, Darko, Martinez, Stephanie, Matiekus, Eimantas, Mejia, Gabriela, Memon, Roha Saeed, Martínez, Xarah Elenne Meza, Mickevičiūtė, Dalia, Milev, Roumen, Mohammed, Muftau, Molina-López, Alejandro, Morozov, Petr, Muhammad, Nuru Suleiman, Mustač, Filip, Naor, Mika S., Nassieb, Amira, Navickas, Alvydas, Okasha, Tarek, Pandova, Milena, Panfil, Anca-Livia, Panteleeva, Liliya, Papava, Ion, Patsali, Mikaella E., Pavlichenko, Alexey, Pejuskovic, Bojana, Pinto Da Costa, Mariana, Popkov, Mikhail, Popovic, Dina, Raduan, Nor Jannah Nasution, Ramírez, Francisca Vargas, Rancans, Elmars, Razali, Salmi, Rebok, Federico, Rewekant, Anna, Flores, Elena Ninoska Reyes, Rivera-Encinas, María Teresa, Saiz, Pilar, de Carmona, Manuel Sánchez, Martínez, David Saucedo, Saw, Jo Anne, Saygili, Görkem, Schneidereit, Patricia, Shah, Bhumika, Shirasaka, Tomohiro, Silagadze, Ketevan, Sitanggang, Satti, Skugarevsky, Oleg, Spikina, Anna, Mahalingappa, Sridevi Sira, Stoyanova, Maria, Szczegielniak, Anna, Tamasan, Simona Claudia, Tavormina, Giuseppe, Tavormina, Maurilio Giuseppe Maria, Theodorakis, Pavlos N., Tohen, Mauricio, Tsapakis, Eva Maria, Tukhvatullina, Dina, Ullah, Irfan, Vaidya, Ratnaraj, Vega-Dienstmaier, Johann M., Vrublevska, Jelena, Vukovic, Olivera, Vysotska, Olga, Widiasih, Natalia, Yashikhina, Anna, Prezerakos, Panagiotis E., and Smirnova, Daria

Published
2022
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6. Automated Speech Analysis in Bipolar Disorder: The CALIBER Study Protocol and Preliminary Results.

Author

Anmella, Gerard, De Prisco, Michele, Joyce, Jeremiah B., Valenzuela-Pascual, Claudia, Mas-Musons, Ariadna, Oliva, Vincenzo, Fico, Giovanna, Chatzisofroniou, George, Mishra, Sanjeev, Al-Soleiti, Majd, Corponi, Filippo, Giménez-Palomo, Anna, Montejo, Laura, González-Campos, Meritxell, Popovic, Dina, Pacchiarotti, Isabella, Valentí, Marc, Cavero, Myriam, Colomer, Lluc, and Grande, Iria

Abstract

Background: Bipolar disorder (BD) involves significant mood and energy shifts reflected in speech patterns. Detecting these patterns is crucial for diagnosis and monitoring, currently assessed subjectively. Advances in natural language processing offer opportunities to objectively analyze them. Aims: To (i) correlate speech features with manic-depressive symptom severity in BD, (ii) develop predictive models for diagnostic and treatment outcomes, and (iii) determine the most relevant speech features and tasks for these analyses. Methods: This naturalistic, observational study involved longitudinal audio recordings of BD patients at euthymia, during acute manic/depressive phases, and after-response. Patients participated in clinical evaluations, cognitive tasks, standard text readings, and storytelling. After automatic diarization and transcription, speech features, including acoustics, content, formal aspects, and emotionality, will be extracted. Statistical analyses will (i) correlate speech features with clinical scales, (ii) use lasso logistic regression to develop predictive models, and (iii) identify relevant speech features. Results: Audio recordings from 76 patients (24 manic, 21 depressed, 31 euthymic) were collected. The mean age was 46.0 ± 14.4 years, with 63.2% female. The mean YMRS score for manic patients was 22.9 ± 7.1, reducing to 5.3 ± 5.3 post-response. Depressed patients had a mean HDRS-17 score of 17.1 ± 4.4, decreasing to 3.3 ± 2.8 post-response. Euthymic patients had mean YMRS and HDRS-17 scores of 0.97 ± 1.4 and 3.9 ± 2.9, respectively. Following data pre-processing, including noise reduction and feature extraction, comprehensive statistical analyses will be conducted to explore correlations and develop predictive models. Conclusions: Automated speech analysis in BD could provide objective markers for psychopathological alterations, improving diagnosis, monitoring, and response prediction. This technology could identify subtle alterations, signaling early signs of relapse. Establishing standardized protocols is crucial for creating a global speech cohort, fostering collaboration, and advancing BD understanding. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Somatic multicomorbidity and disability in patients with psychiatric disorders in comparison to the general population: a quasi-epidemiological investigation in 54,826 subjects from 40 countries (COMET-G study)

Author

Fountoulakis, Konstantinos N., primary, Karakatsoulis, Grigorios N., additional, Abraham, Seri, additional, Adorjan, Kristina, additional, Ahmed, Helal Uddin, additional, Alarcón, Renato D., additional, Arai, Kiyomi, additional, Auwal, Sani Salihu, additional, Berk, Michael, additional, Bjedov, Sarah, additional, Bobes, Julio, additional, Bobes-Bascaran, Teresa, additional, Bourgin-Duchesnay, Julie, additional, Bredicean, Cristina Ana, additional, Bukelskis, Laurynas, additional, Burkadze, Akaki, additional, Cabrera Abud, Indira Indiana, additional, Castilla-Puentes, Ruby, additional, Cetkovich, Marcelo, additional, Colon-Rivera, Hector, additional, Corral, Ricardo, additional, Cortez-Vergara, Carla, additional, Crepin, Piirika, additional, De Berardis, Domenico, additional, Zamora Delgado, Sergio, additional, Lucena, David De, additional, Sousa, Avinash De, additional, Stefano, Ramona Di, additional, Dodd, Seetal, additional, Priyanka Elek, Livia, additional, Elissa, Anna, additional, Erdelyi-Hamza, Berta, additional, Erzin, Gamze, additional, Etchevers, Martin J., additional, Falkai, Peter, additional, Farcas, Adriana, additional, Fedotov, Ilya, additional, Filatova, Viktoriia, additional, Fountoulakis, Nikolaos K., additional, Frankova, Iryna, additional, Franza, Francesco, additional, Frias, Pedro, additional, Galako, Tatiana, additional, Garay, Cristian J., additional, Garcia-Álvarez, Leticia, additional, García-Portilla, Maria Paz, additional, Gonda, Xenia, additional, Gondek, Tomasz M., additional, Morera González, Daniela, additional, Gould, Hilary, additional, Grandinetti, Paolo, additional, Grau, Arturo, additional, Groudeva, Violeta, additional, Hagin, Michal, additional, Harada, Takayuki, additional, Hasan, Tasdik M., additional, Azreen Hashim, Nurul, additional, Hilbig, Jan, additional, Hossain, Sahadat, additional, Iakimova, Rossitza, additional, Ibrahim, Mona, additional, Iftene, Felicia, additional, Ignatenko, Yulia, additional, Irarrazaval, Matias, additional, Ismail, Zaliha, additional, Ismayilova, Jamila, additional, Jakobs, Asaf, additional, Jakovljević, Miro, additional, Jakšić, Nenad, additional, Javed, Afzal, additional, Kafali, Helin Yilmaz, additional, Karia, Sagar, additional, Kazakova, Olga, additional, Khalifa, Doaa, additional, Khaustova, Olena, additional, Koh, Steve, additional, Kopishinskaia, Svetlana, additional, Kosenko, Korneliia, additional, Koupidis, Sotirios A., additional, Kovacs, Illes, additional, Kulig, Barbara, additional, Lalljee, Alisha, additional, Liewig, Justine, additional, Majid, Abdul, additional, Malashonkova, Evgeniia, additional, Malik, Khamelia, additional, Malik, Najma Iqbal, additional, Mammadzada, Gulay, additional, Mandalia, Bilvesh, additional, Marazziti, Donatella, additional, Marčinko, Darko, additional, Martinez, Stephanie, additional, Matiekus, Eimantas, additional, Mejia, Gabriela, additional, Memon, Roha Saeed, additional, Meza Martínez, Xarah Elenne, additional, Mickevičiūtė, Dalia, additional, Milev, Roumen, additional, Mohammed, Muftau, additional, Molina-López, Alejandro, additional, Morozov, Petr, additional, Muhammad, Nuru Suleiman, additional, Mustač, Filip, additional, Naor, Mika S., additional, Nassieb, Amira, additional, Navickas, Alvydas, additional, Okasha, Tarek, additional, Pandova, Milena, additional, Panfil, Anca-Livia, additional, Panteleeva, Liliya, additional, Papava, Ion, additional, Patsali, Mikaella E., additional, Pavlichenko, Alexey, additional, Pejuskovic, Bojana, additional, Pinto Da Costa, Mariana, additional, Popkov, Mikhail, additional, Popovic, Dina, additional, Raduan, Nor Jannah Nasution, additional, Vargas Ramírez, Francisca, additional, Rancans, Elmars, additional, Razali, Salmi, additional, Rebok, Federico, additional, Rewekant, Anna, additional, Ninoska Reyes Flores, Elena, additional, Rivera-Encinas, María Teresa, additional, Saiz, Pilar, additional, Sánchez de Carmona, Manuel, additional, Saucedo Martínez, David, additional, Saw, Jo Anne, additional, Saygili, Görkem, additional, Schneidereit, Patricia, additional, Shah, Bhumika, additional, Shirasaka, Tomohiro, additional, Silagadze, Ketevan, additional, Sitanggang, Satti, additional, Skugarevsky, Oleg, additional, Spikina, Anna, additional, Mahalingappa, Sridevi Sira, additional, Stoyanova, Maria, additional, Szczegielniak, Anna, additional, Tamasan, Simona Claudia, additional, Tavormina, Giuseppe, additional, Tavormina, Maurilio Giuseppe Maria, additional, Theodorakis, Pavlos N., additional, Tohen, Mauricio, additional, Tsapakis, Eva Maria, additional, Tukhvatullina, Dina, additional, Ullah, Irfan, additional, Vaidya, Ratnaraj, additional, Vega-Dienstmaier, Johann M., additional, Vrublevska, Jelena, additional, Vukovic, Olivera, additional, Vysotska, Olga, additional, Widiasih, Natalia, additional, Yashikhina, Anna, additional, Prezerakos, Panagiotis E., additional, and Smirnova, Daria, additional

Published
2024
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17. Predictors of functional outcome in patients with major depression and bipolar disorder: A dynamic network approach to identify distinct patterns of interacting symptoms

Author

Platania, Giuseppe Alessio, primary, Savia Guerrera, Claudia, additional, Sarti, Pierfrancesco, additional, Varrasi, Simone, additional, Pirrone, Concetta, additional, Popovic, Dina, additional, Ventimiglia, Andrea, additional, De Vivo, Simona, additional, Cantarella, Rita Anna, additional, Tascedda, Fabio, additional, Drago, Filippo, additional, Di Nuovo, Santo, additional, Colliva, Chiara, additional, Caraci, Filippo, additional, Castellano, Sabrina, additional, and Blom, Johanna M. C., additional

Published
2023
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25. Clinical and Neurocognitive Predictors of Functional Outcome in Depressed Patients with Partial Response to Treatment: One Year Follow-Up Study

Author

Castellano, Sabrina, Torrent, Carla, Petralia, Maria Cristina, Godos, Justyna, Cantarella, Rita Anna, Ventimiglia, Andrea, De Vivo, Simona, Platania, Silvia, Guarnera, Maria, Pirrone, Concetta, Drago, Filippo, Vieta, Eduard, Di Nuovo, Santo, Popovic, Dina, and Caraci, Filippo

Subjects
cognition, Neuropsychiatric Disease and Treatment, Cognition disorders, SNRI, Neurosciences. Biological psychiatry. Neuropsychiatry, Antidepressius, Antidepressants, Trastorns de la cognició, behavioral disciplines and activities, psychometric tools, Mental depression, SSRI, antidepressant drugs, Neurology. Diseases of the nervous system, Depressió psíquica, RC346-429, major depression, RC321-571, Original Research
Abstract

Sabrina Castellano,1 Carla Torrent,2 Maria Cristina Petralia,3 Justyna Godos,4 Rita Anna Cantarella,5 Andrea Ventimiglia,6 Simona De Vivo,6 Silvia Platania,1 Maria Guarnera,7 Concetta Pirrone,1 Filippo Drago,4 Eduard Vieta,2 Santo Di Nuovo,1 Dina Popovic,2,8,* Filippo Caraci4,9,* 1Department of Educational Sciences, University of Catania, Catania, Italy; 2Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain; 3IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy; 4Oasi Research Institute-IRCCS, Troina 94018, Italy; 5Department of Mental Health, ASP3 Catania, Catania, Italy; 6Villa dei Gerani Clinic ASP3 Catania, Catania, Italy; 7Faculty of Human and Social Sciences, University of Enna “KORE”, Enna, Italy; 8Bipolar Disorders Program, Sheba Medical Center, Ramat Gan, Israel; 9Department of Drug Sciences, University of Catania, Catania, Italy*These authors contributed equally to this workCorrespondence: Sabrina CastellanoDepartment of Educational Sciences, University of Catania, Via Ofelia 1, Catania 95124, ItalyTel +39 0952508060Fax +39 0952508070Email sabrina.castellano@unict.itBackground: Cognitive dysfunction represents a distinct biological and clinical dimension in major depression disorders (MDD) and cognitive performance strongly affects psychosocial functioning in patients diagnosed with MDD.Objective: To assess which neurocognitive variables at baseline predict the functional outcome of MDD patients in a 1-year follow-up study as assessed by Functioning Assessment Short Test (FAST) and whether the improvement observed on affective and cognitive symptoms in our 12 week-prospective observational study after treatment with selective serotonin reuptake inhibitors (SSRIs) and selective noradrenalin reuptake inhibitors (SNRIs) can affect the following long-term psychosocial functional outcome at 1 year in the same MDD patients.Methods: We recruited a total of 31 patients (8 males; 23 females) with MDD who had previously completed a pharmacological treatment with SSRIs (n= 22) or SNRIs (n= 9) for 12 weeks, and then continued the same pharmacological treatment for 1 year. After an average 1-year follow-up, they were interviewed with the FAST to assess functional outcome. Multivariate analyses were applied to identify clinical and neurocognitive predictors of functional outcome.Results: Total Montreal Cognitive Assessment (MoCA), Digit Span forward (Span F) and backward (Span B), and 15 Rey words immediate recall (Rey I) scores significantly correlated with FAST. However, after performing regression models only Rey immediate recall score was useful to predict long-term functional outcome (Pearson correlation coefficient R= − 0.68, p

Published
2020

36. Sultans of Swing

Author

Verdolini, Norma, Menculini, Giulia, Perugi, Giulio, Murru, Andrea, Samalin, Ludovic, Angst, Jules, Azorin, Jean-Michel, Bowden, Charles L, Mosolov, Sergey, Young, Allan H, Barbuti, Margherita, Popovic, Dina, Vieta, Eduard, Pacchiarotti, Isabella, University of Zurich, and Vieta, Eduard

Subjects
Adult, Male, medicine.medical_specialty, Bipolar Disorder, 610 Medicine & health, Context (language use), Logistic regression, 2738 Psychiatry and Mental Health, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, mental disorders, Post-hoc analysis, medicine, Humans, Major depressive episode, Atypical depression, Depressive Disorder, Major, Depressive Disorder, Depression, business.industry, Major, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Cross-Sectional Studies, Mood, 10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics, Major depressive disorder, Female, medicine.symptom, business, Mania, 030217 neurology & neurosurgery
Abstract

OBJECTIVE This post hoc analysis of the BRIDGE-II-MIX study is aimed at evaluating affective lability (AL) as a possible clinical feature of mixed depression and assessing the relationship with atypical depressive features, particularly mood reactivity (MR). METHODS In the BRIDGE-II-MIX multicenter, cross-sectional study, 2,811 individuals suffering from a major depressive episode (MDE; DSM-IV-TR criteria), in the context of bipolar I or II disorder (BD-I, BD-II, respectively) or major depressive disorder, were enrolled between June 2009 and July 2010. Patients with (MDE-AL, n = 694) and without (MDE-noAL, n = 1,883) AL and with (MDE-MR, n = 1,035) or without (MDE-noMR, n = 1,542) MR were compared through χ² test or Student t test. Stepwise backward logistic regression models, respectively testing AL and MR as the dependent variable, were performed to differentiate the 2 clinical constructs. RESULTS AL was positively associated with BD-I (P < .001) and BD-II (P < .001), with DSM-5 mixed (DSM-5-MXS) (P < .001) and atypical (DSM-5-AD) features (P < .001) and negatively associated with MDD (P < .001). In the logistic regression models, MR was the variable most significantly associated with AL and vice versa (P < .001 for both). AL was positively associated with severity of mania and DSM-5-MXS and negatively correlated with severity of depression, while MR was better predicted by atypical symptoms such as hyperphagia, hypersomnia, and leaden paralysis and correlated with both comorbid anxiety disorders and DSM-5-MXS. CONCLUSIONS Mixed and atypical depression may lie on the same continuum. MR and AL could represent the underlying matrix, bridging the gap between mixed and atypical depression.

Published
2019

37. The implications of hypersomnia in the context of major depression: Results from a large, international, observational study

Author

Murru, Andrea, Guiso, Giovanni, Barbuti, Margherita, Anmella, Gerard, Verdolini, Norma, Samalin, Ludovic, Azorin, Jean-Michel, Angst, Jules, Bowden, Charles L., Mosolov, Sergey, Young, Allan H., Popovic, Dina, Valdes, M., Perugi, Giulio, Vieta i Pascual, Eduard, 1963, Pacchiarotti, Isabella, BRIDGE-II-Mix Study Group, Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Fondation FondaMental [Créteil], School of Physics, University College Dublin [Dublin] (UCD), Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, School of Electrical Engineering (ETF), University of Belgrade [Belgrade], Universitat de Barcelona, University of Zurich, and Vieta, E

Subjects
Male, Bipolar Disorder, Internationality, Bipolar depression, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Comorbidity, Logistic regression, 2738 Psychiatry and Mental Health, 0302 clinical medicine, Sleep Initiation and Maintenance Disorders, Insomnia, 2736 Pharmacology (medical), Major depression, Manic-depressive illness, Pharmacology (medical), Depressió psíquica, Depression (differential diagnoses), ComputingMilieux_MISCELLANEOUS, Hypersomnia, Trastorn bipolar, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Sleep disorders, 3. Good health, Psychiatry and Mental health, 3004 Pharmacology, 2728 Neurology (clinical), Mental depression, Neurology, Screening, Mixed features, Female, medicine.symptom, 2803 Biological Psychiatry, Adult, medicine.medical_specialty, 610 Medicine & health, Context (language use), Bivariate analysis, Disorders of Excessive Somnolence, Odds, 03 medical and health sciences, Comorbiditat, Internal medicine, mental disorders, medicine, Humans, Biological Psychiatry, Trastorns del son, Pharmacology, Depressive Disorder, Major, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, medicine.disease, 030227 psychiatry, 10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics, 2808 Neurology, Observational study, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

According to the DSM-5, 'reduction in the need for sleep' is the only sleep-related criteria for mixed features in depressive episodes. We aimed at studying the prevalence, clinical correlates and the role of hypersomnia in a sample of acutely depressed patients. Secondarily, we factors significantly increasing the odds of hypersomnia were studied. We conducted a post-hoc analysis of the BRIDGE-II-Mix study. Variables were compared between patients with hypersomnia (SLEEP+) and with insomnia (SLEEP-) with standard bivariate tests. A stepwise backward logistic regression model was performed with SLEEP+ as dependent variable. A total of 2514 subjects were dichotomized into SLEEP+ (n = 423, 16.8%) and SLEEP- (n = 2091, 83.2%). SLEEP+ had significant higher rates of obese BMI (p < 0.001), BD diagnosis (p = 0.027), severe BD (p < 0.001), lifetime suicide attempts (p < 0.001), lower age at first depression (p = 0.004) than SLEEP-. Also, SLEEP+ had significantly poorer response to antidepressants (AD) such as (hypo)manic switches, AD resistance, affective lability, or irritability (all 0

Published
2018

38. Characterization of rapid cycling bipolar patients presenting with major depressive episode within the BRIDGE‐II‐MIX study.

Author

Antonietta Furio, Maria, Popovic, Dina, Vieta, Eduard, Stukalin, Yelena, Hagin, Michal, Torrent, Carla, Azorin, Jean‐Michel, Angst, Jules, Bowden, Charles L., Mosolov, Sergey, Young, Allan H., and Perugi, Giulio

Subjects
*BORDERLINE personality disorder, *BIPOLAR disorder, *RISK-taking behavior, *IMPULSE (Psychology), *HYPOMANIA, *SYMPTOMS, *ANXIETY disorders
Abstract

Objectives: The "Bipolar Disorders: Improving Diagnosis, Guidance, and Education" (BRIDGE‐II‐Mix) study aimed to estimate the frequency of mixed states in patients with a major depressive episode (MDE) according to different definitions and to compare their clinical validity, looking into specific features such as rapid cycling (RC). Methods: Psychiatric symptoms, socio‐demographic, and clinical variables were collected from a sample of 2811 MDE patients, of which 726 (25.8%) were diagnosed with bipolar disorder (BD). The characteristics of bipolar patients with RC (BD‐RC) and without (BD‐NRC) RC were compared. Results: Of 726 BD patients, 159 (21.9%) met DSM‐5 criteria for RC. BD‐RC group presented a higher number of lifetime depressive episodes (p < 0.001) with shorter duration of depressive episodes, and more psychiatric comorbidities, as well as higher rates of atypical features (p = 0.016) and concomitant (hypo)manic symptoms (irritable mood (p = 0.001); risky behavior (p = 0.005); impulsivity (p = 0.006); and psychomotor agitation (p = 0.029)). Patients with RC had a worse functioning (p = 0.033), more obesity (p = 0.003), and were significantly more likely to be treated with three or more drugs (p = 0.007). Conclusions: Important clinical differences between bipolar patients with and without a RC include more depressive morbidity, higher incidence of anxiety disorders, addiction, bulimia, and borderline personality disorder, as well as atypical features during depression and symptoms such as irritability, risky behavior, impulsivity, and agitation. RC patients had poorer functioning than patients without RC, more obesity, and had to be treated with more drugs. [ABSTRACT FROM AUTHOR]

Published
2021
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39. Manifesto for an international digital mental health network

Author

Maron, Eduard, primary, Baldwin, David S., additional, Balõtšev, Roman, additional, Fabbri, Chiara, additional, Gaur, Vikas, additional, Hidalgo-Mazzei, Diego, additional, Hood, Sean, additional, Juhola, Martti, additional, Kampman, Olli, additional, Kasper, Siegfried, additional, Kärkkäinen, Hilkka, additional, Látalová, Klára, additional, Lähteenvuo, Markku, additional, Mastellos, Nikolas, additional, McTigue, Joseph, additional, Metsallik, Janek, additional, Metspalu, Andres, additional, Nutt, David, additional, Nykänen, Pirkko, additional, Olisa, Nigel, additional, Pogarell, Oliver, additional, Popovic, Dina, additional, Antoni Ramos-Quiroga, Josep, additional, Ross, Peeter, additional, Serretti, Alessandro, additional, Spies, Marie, additional, Thibaut, Florence, additional, Tiainen, Kimmo, additional, Tiihonen, Jari, additional, Vieta, Eduard, additional, Võhma, Ülle, additional, Van Westrhenen, Roos, additional, Zubanovic, Belmin, additional, and Eberhard, Jonas, additional

Published
2019
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41. Aggressiveness in depression: a neglected symptom possibly associated with bipolarity and mixed features

Author

Verdolini, Norma, Perugi, Giulio, Samalin, Ludovic, Murru, Andrea, Angst, Jules, Azorin, Jean-Michel, Bowden, Charles L., Mosolov, Sergey, Young, Allan H., Barbuti, Margherita, Guiso, Giovanni, Popovic, Dina, Vieta i Pascual, Eduard, 1963, Pacchiarotti, Isabella, BRIDGE-II-Mix Study Group, Universitat de Barcelona, Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre for Ecology and Hydrology (CEH), Natural Environment Research Council (NERC), European Southern Observatory [Santiago] (ESO), European Southern Observatory (ESO), University of Zurich, and Vieta, E

Subjects
Adult, Male, medicine.medical_specialty, Bipolar Disorder, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Major depressive episode, 610 Medicine & health, Comorbidity, Logistic regression, 2738 Psychiatry and Mental Health, 03 medical and health sciences, 0302 clinical medicine, Aggressiveness, Borderline Personality Disorder, Internal medicine, Post-hoc analysis, mental disorders, medicine, Humans, Manic-depressive illness, Bipolar disorder, Depressió psíquica, Borderline personality disorder, ComputingMilieux_MISCELLANEOUS, Depression (differential diagnoses), Depressive Disorder, Major, Trastorn bipolar, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, DSM-5 mixed features specifier, Psychiatry and Mental Health, [SCCO.NEUR]Cognitive science/Neuroscience, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Middle Aged, medicine.disease, 030227 psychiatry, Aggression, Substance abuse, Psychiatry and Mental health, Cross-Sectional Studies, Mental depression, 10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics, Female, medicine.symptom, Agressivitat, Psychology, Mania, 030217 neurology & neurosurgery, Clinical psychology
Abstract

OBJECTIVE: To evaluate aggressiveness during a major depressive episode (MDE) and its relationship with bipolar disorder (BD) in a post hoc analysis of the BRIDGE-II-MIX study.METHOD: A total of 2811 individuals were enrolled in this multicenter cross-sectional study. MDE patients with (MDE-A, n = 399) and without aggressiveness (MDE-N, n = 2412) were compared through chi-square test or Student's t-test. A stepwise backward logistic regression model was performed.RESULTS: MDE-A group was more frequently associated with BD (P < 0.001), while aggressiveness was negatively correlated with unipolar depression (P < 0.001). At the logistic regression, aggressiveness was associated with the age at first depressive episode (P < 0.001); the severity of mania (P = 0.03); the diagnosis of BD (P = 0.001); comorbid borderline personality disorder (BPD) (P < 0.001) but not substance abuse (P = 0.63); no current psychiatric treatment (P < 0.001); psychotic symptoms (P = 0.007); the marked social/occupational impairment (P = 0.002). The variable most significantly associated with aggressiveness was the presence of DSM-5 mixed features (P < 0.001, OR = 3.815). After the exclusion of BPD, the variable of lifetime suicide attempts became significant (P = 0.013, OR = 1.405).CONCLUSION: Aggressiveness seems to be significantly associated with bipolar spectrum disorders, independently from BPD and substance abuse. Aggressiveness should be considered as a diagnostic criterion for the mixed features specifier and a target of tailored treatment strategy.

Published
2017

50. Cognitive Complaints in Bipolar Disorder Rating Assessment

Author

Rosa, Adriane R., primary, Mercadé, Clara, additional, Sánchez-Moreno, Jose, additional, Solé, Brisa, additional, Del Mar Bonnin, Caterina, additional, Torrent, Carla, additional, Grande, Iria, additional, Sugranyes, Gisela, additional, Popovic, Dina, additional, Salamero, Manel, additional, Kapczinski, Flávio, additional, Vieta, Eduard, additional, and Martinez-Aran, Anabel, additional

Published
2013
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