614 results on '"Popović, Milica"'
Search Results
2. Immobilization of periodate-oxidized horseradish peroxidase by adsorption on sepiolite
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Surudžić Nevena, Simić Miloš, Crnoglavac-Popović Milica, El Gahwash Reyadh, Spasojević-Savković Milica, Prodanović Radivoje, and Prodanović Olivera
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modified enzyme ,specific activity ,thermostability ,reusability ,Chemistry ,QD1-999 - Abstract
Horseradish peroxidases (HRP), native and periodate-oxidized were immobilized onto sepiolite clay mineral by adsorption. Both peroxidases were adsorbed on this carrier in different quantities. Specific activity of immobilized enzymes was increased with increasing the amount of peroxidase added per gram of sepiolite. The highest specific activity was achieved when 15 mg of peroxidase was added per g of sepiolite. Also, periodate-oxidized enzymes showed similar specific activity as native ones. Stability studies (pH, thermal and operational stability) were conducted for both peroxidases. Residual specific activity of HRP immobilized onto sepiolite declined with an increase of incubation time at 65 °C. Oxidized-peroxidase lost 64 % of the initial activity, whereas native HRP dropped 92 % of its activity after 5 min of incubation at 65 °C. Reduction of the enzyme activity was observed with the temperature increase from 30 to 80 °C. pH profiles of native peroxidase immobilized onto sepiolite were higher in both acidic and basic regions compared to periodate-oxidized enzyme. Oxidized HRP was more successful in studies of operational stability, it retained 42 % of its activity after 4 consecutive cycles of pyrogallol oxidation, whereas native peroxidase kept only 11 % of the original activity.
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- 2024
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3. The method of calculating price reductions in contracts for the international sale of goods
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Popović Milica
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price reduction ,contract for the international sale of goods ,article 50, united nations convention on contracts for the international sale of goods ,method of calculation ,time of calculation ,place of calculation ,Law in general. Comparative and uniform law. Jurisprudence ,K1-7720 - Abstract
The buyer's right to a price reduction represents an institution of Roman law that has, over time, become widely accepted in legal systems with a continental legal tradition. In the context of international sales of goods, Article 50 of the United Nations Convention on Contracts for the International Sale of Goods, which regulates this right, is of particular importance. This paper analyzes the method of calculating price reductions as one of the contentious issues regarding exercising the right to a price reduction, in terms of Article 50 of the Convention. For a comprehensive understanding of the problem, the paper presents the history of the emergence, the sources of the right to a price reduction in contracts for the international sale of goods, as well as the conditions for its application. The central part of the paper is the issue of the method of calculating price reduction, with special reference to the time and place of determining the value of conforming and non-conforming goods for the purpose of their comparison and the application of the calculation formula. These issues were controversial even at the time of the adoption of the Convention itself, and today they are still the subject of discussions in legal theory, while case law is not sufficiently harmonized. The aim of the paper is to draw a conclusion about the method of calculating price reduction, through the analysis of the Convention's provisions, and solutions given in theory, as well as in case law.
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- 2024
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4. Difference in immune responses to Candida albicans in two inbred strains of male rats
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Papic, Mirjana V., Ljujic, Biljana, Zivanovic, Suzana, Papic, Milos, Vuletic, Miona, Petrovic, Ivana, Gazdic Jankovic, Marina, Virijevic, Katarina, Popovic, Milica, and Miletic Kovacevic, Marina
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- 2023
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5. SARS‐CoV‐2 PLpro Inhibition: Evaluating in Silico Repurposed Fidaxomicin's Antiviral Activity Through In Vitro Assessment.
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Protić, Sara, Crnoglavac Popović, Milica, Kaličanin, Nevena, Prodanović, Olivera, Senćanski, Milan, Milićević, Jelena, Stevanović, Kristina, Perović, Vladimir, Paessler, Slobodan, Prodanović, Radivoje, and Glišić, Sanja
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DRUG repositioning , *DRUG therapy , *DRUG development , *PROTEASE inhibitors , *DATABASES , *ANTIVIRAL agents - Abstract
The emergence of drug‐resistant viruses and novel strains necessitates the rapid development of novel antiviral therapies. This need was particularly demanding during the COVID‐19 pandemic. While de novo drug development is a time‐consuming process, repurposing existing approved medications offers a more expedient approach. In our prior in silico screening of the DrugBank database, fidaxomicin emerged as a potential SARS‐CoV‐2 papain‐like protease inhibitor. This study extends those findings by investigating fidaxomicin's antiviral properties in vitro. Our results support further exploration of fidaxomicin as a therapeutic candidate against SARS‐CoV‐2, given its promising in vitro antiviral activity and favorable safety profile. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Exosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds?
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Filipović, Lidija, Kojadinović, Milica, and Popović, Milica
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- 2022
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7. The impact of body weight on the secondary osification centers development and the term of closure of the anterior fontanelle in infants
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Marković-Jovanović Snežana, Jovanović Aleksandar, Stolić Radojica, Popović Milica, and Ivanović Danijela
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infant ,ossification center ,anterior fontanelle ,birth weight ,body weight ,Medicine - Abstract
Introduction: during the infant development, the organ growth is influenced by genetic factors, diet, hormones and many neuropeptides. The secondary ossification center in the hip joint begins to form around the 4th month of life. Primary dentition begins at the age of 5-6 months with the emergence of the central incisor in the maxilla. At birth, 6 fontanelles are present between the plate bones of the cranium. The largest is the anterior or large fontanelle. Objective of our research is to analyze the development of the secondary ossification center in the femoral head in relation to dentition and closure of the anterior fontanelle closure as well as influence of childrens' birth weight and current weight on these processes. Methodology: The study included 284 infants, male and female, aged 3 to 8 months. Clinical examination of the musculoskeletal system, anthropomentric measurements and ultrasonographic findings of the hip joint were performed at the Pediatric Clinic of the Clinical Hospital Center Pristina in Gracanica. Results: The development of secondary ossification centre correlated with child's age, dentition, anterior fontanelle closure, birth weight and delivery method, as well as actual body weight. Anterior fontanelle size was inversely related to age, body weight and secondary ossification. Conclusions: According to regression analysis, body weight is the only factor that has a direct and independent impact on the onset and progression of ossification process. Every additional kilogram of a child's body weight accelerates secondary ossification by 1.3-3.77 times.
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- 2022
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8. The usage of social media marketing in tourism
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Popović Milica
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tourism ,marketing ,social media ,brand ,purchase intention ,Recreation. Leisure ,GV1-1860 - Abstract
Nowadays, the usage of social media has become integral part of life for many generations. These Web-based tools have allowed tourism companies to identify tourists ' needs and keep up with ever-changing market. Thus, this research paper presents the application of social media in tourism marketing, which extend tourism boundaries in innovative way. In this regard, the subject of the paper is to determine if social media have positive impact on business performances in tourism sector and how to incorporate these tools in tourism brand strategies. The paper is based on secondary data, gathered from academic publications from different scientific fields: tourism, marketing and IT. Research results confirmed the primary hypotheses, which indicated that social media have positive impact on tourists 'purchase intentions and brand loyalty, through which business performances of tourism companies have been improved The significance of the research results is reflected as the optimization of social media usage in tourism marketing in order to improve the quality of tourism services and tourists 'satisfaction.
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- 2022
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9. Resistance index of the renal artery measured by doppler ultrasound as a predictor of graft function after kidney transplantation
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Popović Milica, Milić Biljana, Petrović Lada, Ljubičić Bojana, Boganč Tijana, and Ćelić Dejan
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graft survival ,kidney transplantation ,postoperative complication ,prognosis ,renal artery ,ultrasonography ,doppler ,Medicine (General) ,R5-920 - Abstract
Background/Aim. As an optimal treatment of choice for patients with the latest stage of chronic kidney failure (CKD), renal transplantation (Tx) is performed. The resistance index (RI) of the renal artery is measured by Doppler ultrasonography routinely at certain time intervals to show the condition of the renal graft. The value of RI > 0.75 is considered abnormal. The aim of the study was to determine the correlation between the values of the RI index and the function of the transplanted kidney. Methods. We analyzed retrospectively 63 patients in whom kidney transplant was done at the Clinic for Nephrology and Clinical Immunology, the University Clinical Center of Vojvodina, Novi Sad, Serbia, in the period from 2013 to 2017. Doppler of renal blood vessels was made to all examined patients in the first month after the renal trans-plantation. In addition to standard demographic data, all patients had the RI index and its relationship to the function of the transplanted kidney analyzed immediately after transplantation, as well as in the 6th, 12th, and 18th month, and in a certain number of patients in the 24th and 48th month after transplantation. Results. Out of 63 patients, 63.5% were men, and 26.5% were women, with an average age of 47.67 ± 13.62 years. The primary diseases in patients which led to the terminal CKD stage were hypertension in 33.3% and different forms of glomerulonephritis; while other diseases (diabetes mellitus, chronic pyelonephritis, eclampsia, polycystic kidneys, kidney agenesia, and unknown cause) were present in a lower percentage. RI < 0.75 was present in 73%, and RI > 0.75 in 27% of patients. There was no statistically significant association between RI and serum creatinine or creatinine clearance at a given time, and there was no connection between RI and gender, as well as length of previous treatment by HD. There was a statistically significant association between RI and age of kidney recipient, as well as Tx type. Conclusion. In the observed group of patients, RI of renal arteries did not prove to be a good predictor of the function of the transplanted kidney either in the early or later post-transplant periods. RI might have greater predictive significance if it were determined on or immediately after the transplantation procedure.
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- 2022
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10. Family as a context of informal education
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Popović Daliborka R., Minić Vesna Lj., and Popović Milica D.
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informal education ,family ,values ,informal learning ,History of scholarship and learning. The humanities ,AZ20-999 - Abstract
Due to the changed social circumstances and the growing role of informal education in the process of personal development, the aim of the paper is to consider the importance of family activities, which hold the most dominant role in informal education. The key premise of modern society must therefore be based on establishing continuity in the process of lifelong learning, through the necessity of a holistic relationship between education and society. It is important to move away from the classical way of understanding the education as a process of knowledge transfer that takes place in the formal context and focus on the fact that learning is not limited by time, space, and institution. Starting from the fact that the family is the first and foremost system for a child, only with changed roles in different life cycles, an attempt was made to point out key effects on the family, but also on the child by the family, primarily for prosocial development. Prosocial development takes place by modelling behaviours through which the desired value system is expressed and instilled in a child. Regarding the family as educators in informal education, the paper emphasizes the need to monitor procedures that have a scientific and professional basis, with caution against "falling under the influence" of implicit theories of education that are promoted on social networks and in other, modern forms of social groups. In that sense, the necessity of supporting the family in educational activities, which represent the core of informal education in the family context, is emphasized. After considering the basic principles of formal, non-formal and informal education, the paper emphasizes the growing importance of informal education and the role of the family in this process, considering the key settings of parenting for holistic personality development, based on Kant's claim to educate. Namely, the attention was drawn to the educational activities of the family in the process of individual and social development through an informal approach, as well as to the questions of its competence to respond to the challenges posed by the social change.
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- 2022
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11. #2886 Machine learning-based assessment of serum creatinine and NT-proBNP levels for predicting mortality in patients with heart failure and kidney injury
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Đurović, Vladimir, primary, Petrović, Milovan, additional, Ilić, Aleksandra, additional, Milosavljević, Anastazija Stojšić, additional, Milovančev, Aleksandra, additional, Velicki, Lazar, additional, Maksimović, Snežana Čemerlić, additional, Popović, Milica, additional, Majstorović, Gordana Stražmešter, additional, Golubović, Sonja, additional, Knežević, Violeta, additional, and Petrović, Lada, additional
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- 2024
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12. Immobilization of Cell Walls with Laccase in L-DOPA-Alginate Beads and Investigation of the Influence of Photopolymeriza-Tion on the Temperature Stability of Immobilized Cells and Their Ability for Textile Dye Decolorization
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Kokar, Nikolina Popović, primary, Nikoletić, Anamarija, additional, Stanišić, Marija, additional, Crnoglavac Popović, Milica, additional, and Prodanović, Radivoje, additional
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- 2024
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13. Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing
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Willenborg, Sebastian, Sanin, David E., Jais, Alexander, Ding, Xiaolei, Ulas, Thomas, Nüchel, Julian, Popović, Milica, MacVicar, Thomas, Langer, Thomas, Schultze, Joachim L., Gerbaulet, Alexander, Roers, Axel, Pearce, Edward J., Brüning, Jens C., Trifunovic, Aleksandra, and Eming, Sabine A.
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- 2021
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14. SARS-CoV-2 PLpro Inhibition: Evaluating in Silico Repurposed Fidaxomicin's Antiviral Activity Through In Vitro Assessment
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Protić, Sara, Crnoglavac Popović, Milica, Kaličanin, Nevena, Prodanović, Olivera, Senćanski, Milan, Milićević, Jelena, Stevanović, Kristina, Perović, Vladimir R., Paessler, Slobodan, Prodanović, Radivoje, Glišić, Sanja, Protić, Sara, Crnoglavac Popović, Milica, Kaličanin, Nevena, Prodanović, Olivera, Senćanski, Milan, Milićević, Jelena, Stevanović, Kristina, Perović, Vladimir R., Paessler, Slobodan, Prodanović, Radivoje, and Glišić, Sanja
- Abstract
The emergence of drug-resistant viruses and novel strains necessitates the rapid development of novel antiviral therapies. This need was particularly demanding during the COVID-19 pandemic. While de novo drug development is a time-consuming process, repurposing existing approved medications offers a more expedient approach. In our prior in silico screening of the DrugBank database, fidaxomicin emerged as a potential SARS-CoV-2 papain-like protease inhibitor. This study extends those findings by investigating fidaxomicin‘s antiviral properties in vitro. Our results support further exploration of fidaxomicin as a therapeutic candidate against SARS-CoV-2, given its promising in vitro antiviral activity and favorable safety profile.
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- 2024
15. A new approach for activation of the kiwifruit cysteine protease for usage in in-vitro testing
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Nešić, Andrijana, Čavić, Milena, Popović, Milica, and Gavrović-Jankulović, Marija
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- 2021
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16. A Multi-Spectroscopic and Molecular Docking Analysis of the Biophysical Interaction between Food Polyphenols, Urolithins, and Human Serum Albumin.
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Zelenović, Nevena, Ristić, Predrag, Polović, Natalija, Todorović, Tamara, Kojadinović, Milica, and Popović, Milica
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FOURIER transform infrared spectroscopy ,MOLECULAR docking ,SERUM albumin ,GIBBS' free energy ,METABOLITES - Abstract
Secondary polyphenol metabolites, urolithins (UROs), have anti-oxidative, anti-inflammatory, and antidiabetic properties. Therefore, their biological activity relies on blood transport via human serum albumin (HSA) and tissue distribution. The main goal we set was to investigate the interaction between HSA and different URO (URO A, URO B, URO C, URO D, and glucuronidated URO A and B) using a combination of multi-spectroscopic instrumental and in silico approaches. The fluorescence spectroscopy revealed that URO can quench the naturally occurring fluorescence of HSA in a concentration-dependent manner. The HSA fluorescence was quenched by both a static and dynamic mechanism. The results showed that free UROs bind to HSA with higher affinity than their conjugated forms. CD spectroscopy and FTIR revealed that the alpha-helical structure of HSA is preserved. The calculated Gibbs free energy change indicates that the URO–HSA complex forms spontaneously. There is a single binding site on the HSA surface. The molecular docking results indicated that unconjugated Uro binds to Sudlow I, while their conjugation affects this binding site, so in the conjugated form, they bind to the cleft. Docking experiments indicate that all UROs are capable of binding to both thyroxine recognition sites of ligand-bound HSA proteins. Examining interactions under the following conditions (298 K, 303 K, and 310 K, pH 7.4) is of great importance for determining the pharmacokinetics of these bioactive compounds, as the obtained results can be used as a basis for modulating the potential dosing regimen. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Urinary Extracellular Vesicles as a Readily Available Biomarker Source: A Simplified Stratification Method.
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Filipović, Lidija, Spasojević Savković, Milica, Prodanović, Radivoje, Matijašević Joković, Suzana, Stevanović, Sanja, Marco, Ario de, Kosanović, Maja, Brajušković, Goran, and Popović, Milica
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EXTRACELLULAR vesicles ,IMMUNOAFFINITY chromatography ,BIOMARKERS ,ULTRACENTRIFUGATION ,IMMUNOGLOBULINS - Abstract
Urine, a common source of biological markers in biomedical research and clinical diagnosis, has recently generated a new wave of interest. It has recently become a focus of study due to the presence of its content of extracellular vesicles (EVs). These uEVs have been found to reflect physiological and pathological conditions in kidney, urothelial, and prostate tissue and can illustrate further molecular processes, leading to a rapid expansion of research in this field In this work, we present the advantages of an immunoaffinity-based method for uEVs' isolation with respect to the gold standard purification approach performed by differential ultracentrifugation [in terms of purity and antigen presence. The immunoaffinity method was made feasible by combining specific antibodies with a functionalized polymethacrylate polymer. Flow cytometry indicated a significant fluorescence shift, validating the presence of the markers (CD9, CD63, CD81) and confirming the effectiveness of the isolation method. Microscopy evaluations have shown that the morphology of the vesicles remained intact and corresponded to the expected shapes and dimensions of uEVs. The described protocol is inexpensive, fast, easy to process, has good reproducibility, and can be applied to further biological samples. [ABSTRACT FROM AUTHOR]
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- 2024
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18. The application of geographic information systems in destination marketing
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Popović Milica and Milićević Snežana
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geographic information systems (gis) ,tourism destination ,destination marketing ,integrated marketing activities ,promotion in tourism ,Commerce ,HF1-6182 ,Economics as a science ,HB71-74 - Abstract
Contemporary business trends influence tourism destinations to use advantages that modern information technology provides. Geographic information systems (GIS) could be used for those purposes, especially in area of marketing management. In this regard, the subject of this paper is to determine if GIS application in destination marketing has positive impact for tourism offer and demand. The paper is based on secondary data, gathered from academic publications from different scientific fields: tourism and hospitality, marketing and ICT. Research results confirmed the primary hypothesis, which indicated that GIS application could be beneficial for both tourism offer and demand. The significance of the research results is reflected as a contribution to theoretical framework of GIS in the tourism, as well as in making a foundation for implementation of those systems in practical marketing activities on the level of the tourism destination.
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- 2021
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19. Prevalence of C-shaped second mandibular molar canals in the population of central Serbia: A cone-beam computed tomography study
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Živanović Suzana, Papić Miloš, Radović Mirjana, Mišić Aleksandra, Živić Miloš, and Popović Milica
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endodontics ,tooth root ,tooth anomalies ,molar ,tomography ,serbia ,Medicine (General) ,R5-920 - Abstract
Background/Aim. C-shaped canals are a complex morphological variation of the tooth root canal system that, if present, could greatly affect the outcome of endodontic therapy. The prevalence of these canal configurations varies between the populations of different ethnic and geographical origins. Therefore, the goal of this study was to analyze the prevalence and morphology of mandibular second molar C-shaped canals in the population of Central Serbia. Methods. The study included a total of 1 99 mandibular second molars receiving a cone-beam computed tomography (CBCT) examination and determining the presence of C-shaped canal systems, their configuration, minimal wall thickness and its relative position on axial cross-sections at the coronal, middle, and apical level. Results. The prevalence of C-shaped mandibular second molars was 5.53%. C1 canal configuration was the most frequent at the coronal cross-section, while C2 configuration was the most frequent at middle and apical cross-sections. Minimal wall thickness decreased going apically, with the mean value of 1.01 mm at the coronal, 0.87 mm at the middle, and 0 .67 mm at the apical cross-sections. Minimal wall thickness was mostly directed lingually at all cross-sectional levels. Conclusion. C-shaped canals should be expected in mandibular second molars of the population of Central Serbia. CBCT was shown to be the most valuable technique to determine C-shaped canals and facilitate understanding of the C-shaped canal morphology; its implementation could improve the success of endodontic therapy, especially if the complex root canal configuration is present.
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- 2021
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20. Development of Crohn´s disease in a patient with ankylosing spondylitis and essential thrombocythemia folowing etanercept therapy: A case report and review of the literature
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Milić Biljana, Ilić Tatjana, Popović Milica, Savić Aleksandar, Jocić Tatiana, and Petrović Lada
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biological therapy ,comorbidity ,crohn`s disease ,drug utilization ,spondylitis, ankylosing ,thrombocythemia, essential ,Medicine (General) ,R5-920 - Abstract
Introduction. The development of inflammatory bowel disease during the treatment with tumor necrosis factor-α inhibitors is seen in patients with ankylosing spondylitis. Crohn´s disease is the mainly developing form, and etanercept is the most frequently associated agent. Although thrombocytosis in patients with ankylosing spondylitis and inflammatory bowel diseases is often seen due to chronic inflammation, iron deficiency anemia or drug administration, presence of essential thrombocythemia is not common. To our knowledge, there is no published data of coexistence of these three diseases in one patient. Case report. We reported a 35-year-patient with simultaneous presentation of ankylosing spondylitis and essential thrombocythemia. Due to hepatotoxicity of initial treatment with sulfasalazine and metotrexate, tumor necrosis factor-α inhibitor (etanercept) was introduced. Both diseases were well controlled until Crohn´s disease emerged. Two years after switching from etanercept to adalimumab all three coexisting diseases were in remission. Conclusion. Treatment with tumor necrosis factor-α inhibitors significantly improved clinical outcome of patients with chronic inflammatory diseases. However, the appearance of adverse effects may cause a discontinuation or change of a drug. The existence of comorbidities additionally complicates the treatment of such patients.
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- 2021
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21. Predictors of renal outcome in ANCA-assosiated glomerulonephritis
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Ljubičić Bojana, Azaševac Tijana, Popović Milica, Živković Siniša, Božić Dušan, and Ćelić Dejan
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glomerulonephritis ,antibodies, antineutrophil cytoplasmic ,glomerular filtration rate ,mortality ,Medicine (General) ,R5-920 - Abstract
Backgraund/Aim. Primary anti-neutrophil cytoplasmatic antibody (ANCA)-associated vasculitis are chronic multisystemic autoimmune diseases which include microscopic polyangitis (MPA), granulomatosis with polyangitis (WG), eosinophilic granulomatosis with polyangitis (EPGA; churg-strauss syndrome – CSS), and also a localized forms of ill-ness. In our research, we studied clinical and serological parameters in patients, in order to find out which of them would be the best predictor of renal outcome in ANCA-associated vasculitis. Methods. Data from 42 patients with diagnose of MPA (9), WG (17), EPGA (0), CSS (0), and al-so idiopathic rapidly progressive glomerulonephritis (ROEB) without immune deposits (renal-limited vasculitis – 16) were analyzed. Cockroft formula was used for calculating the glomerular filtration in the moment of presenting the illness, and also after five year follow-up period. Other factors that were analyzed are: gender, age, type of ANCA antibodies, type of infections, stage of chronic kidney dis-ease, need for heamodialysis and mortality. Results. Of a total of 42 patients, 17 (40.48%) were male. The average age of the patients at the time of diagnosis was 57.8 (± 10.44) years. Seventeen patients (40.48%) had a diagnosis of WG, 9 (21.43%) MPA, and 16 (38.09%) iRPGN. The presence of positive anti-proteinase (anti-PR3) antibodies was confirmed i n 1 8 patients, a nd a nti-MPO antibodies in 17 patients. Three patients had both subtypes of ANCA antibodies (anti-PR3 and anti-MPO). Initially, 12 patients required heamodialysis treatment. Twenty nine patients had a complete and 13 patients had partial remission. Out of the total number of patients, 8 patients (19.04%) developed the terminal renal failure stage, and ended up on a chronic dialysis program. During a five-year follow-up period, 12 patients (28.57%) resulted in death. The age of the patient proved to be statistically significant predictor of glomerular filtration rate (GFR) at the moment of presentation of the disease (p = 0.011). GFR t = 0 was statistically significant (p = 0.000) for the evaluation of kidney function outcomes in ANCA-associated glomerulonephritis. Conclusion. Kidney function in the moment of illness presentation, determined by GFR t = 0, is the most important significant factor for predicting renal outcome in ANCA-associated vasculitis, and also the mortality in these patients.
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- 2021
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22. Highly cited papers in dental medicine based on essential science indicators
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Jaćimović Jelena, Petrović Renata, Divnić-Resnik Tihana, Pajević Tina, Popović Milica, Stamenković Dejan, and Stratimirović Đorđe
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bibliometrics ,social network analysis ,knowledge discovery ,research fronts ,dentistry ,Medicine - Abstract
Introduction/Objective. Essential Science Indicators (ESI) Highly Cited Papers (HCPs) refer to the most influential scientific articles and breakthrough research within a research field in the past decade. This study aimed to identify the characteristics of ESI HCPs in the subject category Dentistry, Oral Surgery and Medicine, to recognize authors, institutions and countries of origin, and determine research trends that attracted the most scientific interest in dentistry. Methods. A descriptive analysis of bibliographic data, network extraction and visualization were completed. Furthermore, analyzed ESI HCPs were classified according to a field of interest, main research domain, type of study, and level of evidence. Results. The set of 185 dental HCPs was published in 42 journals from 2010 to 2020, with an average number of 211.7 citations per paper. Nearly half of HCPs were issued by the Journal of Dental Research, Dental Materials, and Journal of Clinical Periodontology. There were 765 authors affiliated with 351 institutions from 42 countries. The most productive institutions were the University of Hong Kong, the University of Michigan, and the University of Bern. The United States of America contributed with the highest number of publications, followed by China, and the United Kingdom. Dental materials, dental implantology, periodontology, and oral and maxillofacial surgery represented areas of significant interest within this subject category. The highest proportion of HCPs were narrative and systematic reviews, expert opinions, consensus reports, and in vitro оr lab studies. Conclusion. Results obtained from this study can provide valuable information for researchers to better identify present and future hotspots in dental research.
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- 2021
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23. Efficient dye removal by Streptomyces cyaneus lacasse heterologously expressed within S. cerevisiae cell walls immobilized within tyramine-modified alginate beads using visible light photopolymerization
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Stanić, Dragana Josić, primary, Kokar, Nikolina Popović, additional, Stošić, Anja, additional, Popović, Milica Crnoglavac, additional, Prodanović, Olivera, additional, Vladisavljević, Goran, additional, and Prodanović, Radivoje, additional
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- 2024
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24. State of the Art Technologies for High Yield Heterologous Expression and Production of Oxidoreductase Enzymes: Glucose Oxidase, Cellobiose Dehydrogenase, Horseradish Peroxidase, and Laccases in Yeasts P. pastoris and S. cerevisiae
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Crnoglavac Popović, Milica, primary, Stanišić, Marija, additional, and Prodanović, Radivoje, additional
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- 2024
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25. UWB Microwave Breast Screening with Self-Mixed Baseband Analog Signal Processing
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Taherzadeh, Mohammad, primary, Tabatabaei, Maryam, additional, Ghamati, Maryam, additional, Kakhki, Amin Pourvali, additional, Fortaleza, Leonardo, additional, Nabki, Frederic, additional, and Popović, Milica, additional
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- 2024
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26. Surface Wave and Back Radiation Suppression in Microwave Breast Screening
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Mokhtari, Milad, primary and Popović, Milica, additional
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- 2024
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27. Marketing and modern business conditions
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Popović, Milica, primary
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- 2024
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28. Application of quantitative models in the organization of the financial function of agricultural enterprises
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Milojević Ivan, Mihajlović Milan, Popović Milica, and Pantić Nemanja
- Subjects
financial function ,optimization ,agricultural enterprises ,Agriculture - Abstract
The role and content of the financial function can be seen through the identification of its tasks. They determine the volume and method of organization of the financial function in agricultural enterprises. Hierarchical priorities of tasks, their volume and complexity, the impact on business efficiency are just some aspects that affect its organization. Multi-criteria optimization methods can be used in choosing the organization and setting the model of job specialization within the organizational structure of the financial function of agricultural enterprises. By applying the individual methods that have been applied so far, not all requirements could be fully covered, so in this paper we applied a hybrid optimization model - DEMATELTOPSIS. The DEMATEL method was used for obtaining the weighting coefficients of the criteria on the basis of which the evaluation of alternatives was performed. The selection of criteria for evaluating the model was based on the analysis of the available literature. Evaluation and selection of models was performed using a multicriteria method - TOPSIS. The paper presents the practical application and sensitivity analysis of the TOPSIS method.
- Published
- 2020
29. Cone-beam computed tomography study of tooth root and canal morphology of permanent molars in a Serbian population
- Author
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Popović Milica, Živanović Suzana, Vučićević Tamara, Grujović Miona, and Papić Miloš
- Subjects
tooth root ,molar ,cone-beam computed tomography ,serbia ,Medicine (General) ,R5-920 - Abstract
Background/Aim. For successful endodontic therapy, it is necessary to know root morphology. Therefore, the aim of our study was to analyze root canal morphology and root canal length of permanent molars in a Serbian population, using cone-beam computed tomography (CBCT). Methods. The study included a total of 305 maxillary molars, and 280 mandibular molars receiving cone-beam computed tomography examination and determined root numbers, canal morphology according to Vertucci classification, and canal lengths. Results were correlated with sex and tooth location in the jaw. Results. The mesiobuccal roots of first maxillary molars showed Vertucci type I in 45.7%, followed by type II in 29% of cases. For the second molar, Vertucci type I was found in 60.5% of cases in mesiobuccal canals. Palatal and distobuccal canals mostly presented Vertucci type I configuration. The mesial roots of mandibular molars had the highest frequency of two canals with Vertucci type IV as the most frequent for the first molar, and Vertucci type II for the second molar. Distal roots most commonly had one canal in both molars. Palatal canal length was the highest in maxillary first molars, with the mean value of 20.62 mm, while in second molars, the highest length value was for the mesiobuccal canal (20.09 mm). In both mandibular molars the mesial root canal was the longest one. Differences were found according to sex and tooth location in the jaw. Conclusion. Mesiobuccal roots of maxillary first molars had two canals; it was more frequently compared to second molars. Mesial roots of mandibular molars showed same frequency of two canals, and diversity in Vertucci types. Male patients tended to have higher complexity of root canal morphology compared to that of females. CBCT can improve understanding of the root canal morphology.
- Published
- 2020
- Full Text
- View/download PDF
30. Arginine-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a prospective diagnostic study
- Author
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Winzeler, Bettina, Cesana-Nigro, Nicole, Refardt, Julie, Vogt, Deborah R, Imber, Cornelia, Morin, Benedict, Popovic, Milica, Steinmetz, Michelle, Sailer, Clara O, Szinnai, Gabor, Chifu, Irina, Fassnacht, Martin, and Christ-Crain, Mirjam
- Published
- 2019
- Full Text
- View/download PDF
31. Photopolymerization of L-DOPA-Alginate Immobilized Cell Wall Laccase for Textile Dye Decolorization.
- Author
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Kokar, Nikolina Popović, Nikoletić, Anamarija, Stanišić, Marija, Crnoglavac Popović, Milica, and Prodanović, Radivoje
- Subjects
ALGINATES ,LACCASE ,TEXTILE dyeing ,BROWN algae ,BIOMASS energy - Abstract
Alginate is a naturally occurring polymer derived from brown algae biomass, which has numerous applications in various fields. Chemical modification of alginate is widely used to improve alginate's physicochemical properties and provide new potential for multiple applications. In this article, we modified alginate with L-DOPA, using periodate oxidation and reductive amination, to obtain more suitable biopolymer for biocatalyst immobilization and hydrogel formation. Obtained modified alginate was used for the immobilization of laccase on cell walls. For this purpose, laccase from Streptomyces cyaneus was expressed on the surface of Saccharomyces cerevisiae EBY100 cells. The obtained cell wall laccase was immobilized within L-DOPA-alginate beads by crosslinking the L-DOPA-alginate with calcium ions and laccase. The effect of additional crosslinking of beads by green light-induced photopolymerization with eosin Y was investigated. The immobilized laccase systems were used for dye decolorization and investigated in multiple treatment processes. Beads with L-DOPA-alginate with a higher degree of modification (5.0 mol%) showed higher enzymatic activity and better decolorization efficiency than those with a lower degree of modification (2.5 mol%). Obtained immobilized biocatalysts are suitable for decolorizing dye Evans Blue due to their high efficiency and reusability. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
32. State of the Art Technologies for High Yield Heterologous Expression and Production of Oxidoreductase Enzymes: Glucose Oxidase, Cellobiose Dehydrogenase, Horseradish Peroxidase, and Laccases in Yeasts P. pastoris and S. cerevisiae
- Author
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Popović, Milica Crnoglavac, primary, Stanišić, Marija, additional, and Prodanović, Radivoje, additional
- Published
- 2023
- Full Text
- View/download PDF
33. Unusual anatomy of permanent maxillary and mandibular molars: Case reports
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Mišić Aleksandra, Živanović Suzana, Radović Mirjana, Papić Miloš, and Popović Milica
- Subjects
single rooted molars ,unusual anatomy ,dental radiography ,Medicine - Abstract
Introduction. The anatomy and morphology of the roots and root canal systems of multi-rooted teeth, especially the molars, shows numerous variations. Preoperative radiography, in particular cone-beam computed tomography (CBCT), has exceptional significance in detecting anatomical variations and unusual root canal morphologies, which are extremely important to be familiar with in order to undertake successful endodontic therapy and minimize procedural errors. Outline of cases. This report presents cases of incidental diagnosis of an unusual root anatomy and root canal morphology of permanent molars in two patients. Diagnosis in the first case was made using orthopantomography and confirmed after extraction therapy. The second case reviled unusual root anatomy and root canal morphology of the permanent molar after preoperative CBCT imaging. Conclusion. Anatomical and morphological variations of roots and root canal systems can occur in any tooth. Clinicians should expect these variations, which should be thoroughly investigated when considering dental treatment.
- Published
- 2019
- Full Text
- View/download PDF
34. Experimental analysis of individual EMF exposure for GSM/UMTS/WLAN user devices
- Author
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Popović, Milica, Koprivica, Mladen, Milinković, Jelena, and Nešković, Aleksandar
- Published
- 2019
- Full Text
- View/download PDF
35. Finger Models: Example of Complex Geometry in Investigations on Microwave Skin Cancer Diagnosis
- Author
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Shang, Shangyang, primary and Popović, Milica, additional
- Published
- 2023
- Full Text
- View/download PDF
36. Conformal Occipital 18-Channel Receive-Only RF Coil for 3T MRI
- Author
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Mathieu, William, primary, Popović, Milica, additional, and Farivar, Reza, additional
- Published
- 2023
- Full Text
- View/download PDF
37. Novel Antenna Design for Surface Wave Suppression in Microwave Breast Screening
- Author
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Mokhtari, Milad, primary and Popović, Milica, additional
- Published
- 2023
- Full Text
- View/download PDF
38. Microwave breast cancer detection via cost-sensitive ensemble classifiers: Phantom and patient investigation
- Author
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Li, Yunpeng, Porter, Emily, Santorelli, Adam, Popović, Milica, and Coates, Mark
- Published
- 2017
- Full Text
- View/download PDF
39. Exosomal Prostate-Specific Membrane Antigen (PSMA) and Caveolin-1 as Potential Biomarkers of Prostate Cancer—Evidence from Serbian Population.
- Author
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Matijašević Joković, Suzana, Korać, Aleksandra, Kovačević, Sanja, Djordjević, Ana, Filipović, Lidija, Dobrijević, Zorana, Brkušanin, Miloš, Savić-Pavićević, Dušanka, Vuković, Ivan, Popović, Milica, and Brajušković, Goran
- Subjects
PROSTATE-specific antigen ,CAVEOLINS ,TUMOR markers ,EXOSOMES ,PROSTATE cancer ,BENIGN prostatic hyperplasia - Abstract
Prostate-specific membrane antigen (PSMA) and caveolin-1 are membrane proteins that are overexpressed in prostate cancer (PCa) and are involved in tumor growth and increase in aggressiveness. The aim of the present study is therefore to evaluate PSMA and caveolin-1 proteins from plasma exosomes as effective liquid biopsy biomarkers for PCa. This study included 39 patients with PCa and 33 with benign prostatic hyperplasia (BPH). The shape and size of the exosomes were confirmed by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) analysis. Immunogold analysis showed that PSMA is localized to the membrane of exosomes isolated from the plasma of both groups of participants. The relative protein levels of PSMA and caveolin-1 in the plasma exosomes of PCa and BPH patients were determined by Western blot analysis. The relative level of the analyzed plasma exosomal proteins was compared between PCa and BPH patients and the relevance of the exosomal PSMA and caveoin-1 level to the clinicopathological parameters in PCa was investigated. The analysis performed showed an enrichment of exosomal PSMA in the plasma of PCa patients compared to the exosomes of men with BPH. The level of exosomal caveolin-1 in plasma was significantly higher in PCa patients with high PSA levels, clinical-stage T3 or T4 and in the group of PCa patients with aggressive PCa compared to favorable clinicopathological features or tumor aggressiveness. Plasma exosomes may serve as a suitable object for the identification of potential biomarkers for the early diagnosis and prognosis of PCa as well as carriers of therapeutic agents in precision medicine of PCa treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
40. Melatonin as a Promising Anti-Inflammatory Agent in an In Vivo Animal Model of Sepsis-Induced Rat Liver Damage.
- Author
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Benedeto-Stojanov, Daniela, Ničković, Vanja P., Petrović, Gordana, Rancić, Andrija, Grgov, Ivan, Nikolić, Gordana R., Marčetić, Zoran P., Popović, Milica R., Lazarević, Milan, Mitić, Katarina V., and Sokolović, Dušan
- Subjects
SEPSIS ,ANTI-inflammatory agents ,NEUTROPHIL lymphocyte ratio ,LYMPHOCYTE count ,ANIMAL models in research ,LIVER - Abstract
Melatonin (MLT), earlier described as an effective anti-inflammatory agent, could be a beneficial adjunctive drug for sepsis treatment. This study aimed to determine the effects of MLT application in lipopolysaccharide (LPS)-induced sepsis in Wistar rats by determining the levels of liver tissue pro-inflammatory cytokines (TNF-α, IL-6) and NF-κB as well as hematological parameters indicating the state of sepsis. Additionally, an immunohistological analysis of CD14 molecule expression was conducted. Our research demonstrated that treatment with MLT prevented an LPS-induced increase in pro-inflammatory cytokines TNF-α and IL-6 and NF-κB levels, and in the neutrophil to lymphocyte ratio (NLR). On the other hand, MLT prevented a decrease in the blood lymphocyte number induced by LPS administration. Also, treatment with MLT decreased the liver tissue expression of the CD14 molecule observed after sepsis induction. In summary, in rats with LPS-induced sepsis, MLT was shown to be a significant anti-inflammatory agent with the potential to change the liver's immunological marker expression, thus ameliorating liver function. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
41. Emphysematous pyelonephritis - case report and review of literature
- Author
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Ćelić Dejan, Božić Dušan, Petrović Kosta, Živojinov Srđan, Đurđević-Mirković Tatjana, and Popović Milica
- Subjects
pyelonephritis ,emphysema ,diabetes mellitus, type 1 ,drainage ,treatment outcome ,Medicine (General) ,R5-920 - Abstract
Introduction. Emphysematous pyelonephritis (EPN) is a severe, potentially fatal necrotizing infection of the kidney with the clinical picture ranging from the mild abdominal pain and discomfort to the septic shock and multiorgan failure. We presented here a case of EPN in a poorly controlled diabetic patient that was the first registered case of EPN in our clinic for more than ten years. Case report. A 78-year-old diabetic male patient was referred to the Clinic for Nephrology and Clinical Immunology of the Clinical Center of Vojvodina, Novi Sad, Serbia, with weakness, malaise, abdominal discomfort and reduced daily urine volume. After complete physical exam, laboratory work up, echosonographic and computed tomography scanning we diagnosed the patient with EPN class IV, according to the Huang and Tseng classification, with the presence of 5 risk factors for mortality (systolic blood pressure below 90 mmHg, altered consciousness, thrombocytopenia, elevated serum creatinine level, bilateral disease). Treatment with conservative therapy and percutaneous drainage was not successful, further deteorioration of the patient status ensued so the patient passed away on the 8th day of hospitalization due to the development of septic shock with multiorgan failure that was refractory to all measures that were instituted. Conclusion. EPN is a severe, potentially fatal necrotizing inflammation of the kidney and surrounding tissue. Management and prognosis of this disease depends on the clinical status, risk factors and radiological classification of the disease.
- Published
- 2017
- Full Text
- View/download PDF
42. Interactions of Different Urolithins With Bovine Serum Albumin
- Author
-
Zelenović, Nevena, Kojadinovic, Milica, Filipović, Lidija, Vucic, Vesna, Milčić, Miloš, Arsić, Aleksndra, Popović, Milica, Zelenović, Nevena, Kojadinovic, Milica, Filipović, Lidija, Vucic, Vesna, Milčić, Miloš, Arsić, Aleksndra, and Popović, Milica
- Abstract
Backgound/Objectives Urolithins (UROs) are the metabolites derived from the gut microbial action on ellagitannins and ellagic acid-rich foods. Following their absorption in the intestine, UROs are transported through the systemic circulation to various tissues where they can express their biological function as antimicrobial, anti-inflammatory, and anticancer agents. In addition to blood plasma, where they can be found as glucuronide and sulfate conjugates, they are also found in urine. Therefore, the interactions of UROs with serum proteins are of great clinical interest. Methods A powerful technique for examining these urolithin-serum protein interactions is fluorescence spectroscopy. Bovine serum albumin (BSA) is a particularly suitable model protein because it is readily available, affordable, and similar to human serum albumin. This work aimed to study the binding of UROs (urolithin A, UROA and urolithin B, UROB) and their glucuronide conjugates (UROAG and UROBG) to BSA by quenching the intrinsic fluorescence of protein. Results The spectra obtained showed that the binding process is influenced by the polyphenol's structure and the conjugation process with the glucuronide. The calculated Stern Vollmer binding constants (Ksv): UROA and UROB Ksv were 59236 ± 5706 and 69653 ± 14922, respectively, while for UROAG and UROBG, these values were 15179 ± 2770 and 9462 ± 1955, respectively, which showed that the binding affinity decreased with glucuronidation. Molecular docking studies confirmed that all of the studied molecules will bind favorably to BSA. The preferential binding site for both UROs and UROGs is Sudlow I, while UROs will also bind to Sudlow II. URO-Gs can bind to BSA in the cleft region with lower binding scores than for the Sudlow I binding site. Conclusion The aglycone's higher hydrophobicity increases the binding affinity to BSA, thus reducing its bioavailability in the blood.
- Published
- 2023
43. Recent Developments in Bioprocessing of Recombinant Antibody Fragments
- Author
-
Zelenović, Nevena, Filipović, Lidija, Popović, Milica, Zelenović, Nevena, Filipović, Lidija, and Popović, Milica
- Abstract
Biotechnological and biomedical applications of antibodies have been on a steady rise since the 1980s. As unique and highly specific bioreagents, monoclonal antibodies (mAbs) have been widely exploited and approved as therapeutic agents. However, the use of mAbs has limitations for therapeutic applications. Antibody fragments (AbFs) with preserved antigen-binding sites have a significant potential to overcome the disadvantages of conventional mAbs, such as heterogeneous tissue distribution after systemic administration, especially in solid tumors, and Fc-mediated bystander activation of the immune system. AbFs possess better biodistribution coefficient due to lower molecular weight. They preserve the functional features of mAbs, such as antigen specificity and binding, while at the same time, ensuring much better tissue penetration. An additional benefit of AbFs is the possibility of their production in bacterial and yeast cells due to the small size, more robust structure, and lack of posttranslational modifications. In this review, we described current approaches to the AbF production with recent examples of AbF synthesis in bacterial and yeast expression systems and methods for the production optimization.
- Published
- 2023
44. Isolation and characterization of extracellular vesicles from pleural effusion samples of patients with advanced non-small cell lung cancer
- Author
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Vuković, Miodrag, Filipović, Lidija, Popović, Milica, Petrović, Nina, Tanić, Miljana, Janković, Radmila, Korać, Aleksandra, Čavić, Milena, Vuković, Miodrag, Filipović, Lidija, Popović, Milica, Petrović, Nina, Tanić, Miljana, Janković, Radmila, Korać, Aleksandra, and Čavić, Milena
- Abstract
Introduction: The incidence of lung cancer (LC) in Serbia has increased over the last three decades. Up to 40% of patients with advanced non-small cell lung cancer (NSCLC) develop pleural effusion (PE). The aim of this study was to evaluate the usability of existing methods for isolation of extracellular vesicles from PE samples of patients with advanced non-small cell lung cancer and to characterize them for further use in the clinical/diagnostic/research setting. Material & Methods: PE samples diluted in PBS (1:1) from patients with advanced NSCLC were used. In-house spherical porous methacrylate-based copolymer coupled with VHH antibodies was used for the isolation of extracellular vesicles (EV) from PE samples. Flow-cytometry was performed for detection of exosomal markers. Results: A pool of PE was prepared from 5 patients with advanced NSCLC. Flow cytometry confirmed that the isolation of EVs was successful using the in-house affinity chromatography method. The presence of CD9 antigen was detected, as well as a decrease in the signal after the addition of Triton X-100. Further plans include the analysis of CD63 and CD81 antigens using flow cytometry, NTA analysis to determine the number and diameter of obtained vesicles, as well as TEM and SEM to determine their morphology. Discussion: We aim to investigate for the first time whether this method is applicable to pleural effusion samples as a new cancer liquid biopsy sample type. We also plan to evaluate the method in comparison with a commercial isolation kit.
- Published
- 2023
45. Recent Developments in Bioprocessing of Recombinant Antibody Fragments
- Author
-
Zelenović, Nevena D., Filipović, Lidija, Popović, Milica M., Zelenović, Nevena D., Filipović, Lidija, and Popović, Milica M.
- Abstract
Biotechnological and biomedical applications of antibodies have been on a steady rise since the 1980s. As unique and highly specific bioreagents, monoclonal antibodies (mAbs) have been widely exploited and approved as therapeutic agents. However, the use of mAbs has limitations for therapeutic applications. Antibody fragments (AbFs) with preserved antigen-binding sites have a significant potential to overcome the disadvantages of conventional mAbs, such as heterogeneous tissue distribution after systemic administration, especially in solid tumors, and Fc-mediated bystander activation of the immune system. AbFs possess better biodistribution coefficient due to lower molecular weight. They preserve the functional features of mAbs, such as antigen specificity and binding, while at the same time, ensuring much better tissue penetration. An additional benefit of AbFs is the possibility of their production in bacterial and yeast cells due to the small size, more robust structure, and lack of posttranslational modifications. In this review, we described current approaches to the AbF production with recent examples of AbF synthesis in bacterial and yeast expression systems and methods for the production optimization.
- Published
- 2023
46. Interactions of Different Urolithins With Bovine Serum Albumin
- Author
-
Zelenović, Nevena D., Kojadinović, Milica I., Filipović, Lidija, Vučić, Vesna M., Milčić, Miloš K., Arsic, Aleksndra, Popović, Milica M., Zelenović, Nevena D., Kojadinović, Milica I., Filipović, Lidija, Vučić, Vesna M., Milčić, Miloš K., Arsic, Aleksndra, and Popović, Milica M.
- Abstract
Backgound/ObjectivesUrolithins (UROs) are the metabolites derived from the gut microbial action on ellagitannins and ellagic acid-rich foods. Following their absorption in the intestine, UROs are transported through the systemic circulation to various tissues where they can express their biological function as antimicrobial, anti-inflammatory, and anticancer agents. In addition to blood plasma, where they can be found as glucuronide and sulfate conjugates, they are also found in urine. Therefore, the interactions of UROs with serum proteins are of great clinical interest.MethodsA powerful technique for examining these urolithin-serum protein interactions is fluorescence spectroscopy. Bovine serum albumin (BSA) is a particularly suitable model protein because it is readily available, affordable, and similar to human serum albumin. This work aimed to study the binding of UROs (urolithin A, UROA and urolithin B, UROB) and their glucuronide conjugates (UROAG and UROBG) to BSA by quenching the intrinsic fluorescence of protein.ResultsThe spectra obtained showed that the binding process is influenced by the polyphenol's structure and the conjugation process with the glucuronide. The calculated Stern Vollmer binding constants (Ksv): UROA and UROB Ksv were 59236 ± 5706 and 69653 ± 14922, respectively, while for UROAG and UROBG, these values were 15179 ± 2770 and 9462 ± 1955, respectively, which showed that the binding affinity decreased with glucuronidation. Molecular docking studies confirmed that all of the studied molecules will bind favorably to BSA. The preferential binding site for both UROs and UROGs is Sudlow I, while UROs will also bind to Sudlow II. URO-Gs can bind to BSA in the cleft region with lower binding scores than for the Sudlow I binding site.ConclusionThe aglycone's higher hydrophobicity increases the binding affinity to BSA, thus reducing its bioavailability in the blood.
- Published
- 2023
47. La importancia de las prácticas profesionales supervisadas en la formación de profesores de español en Serbia
- Author
-
Popović, Milica Z. and Popović, Milica Z.
- Abstract
In order to become a teacher in general, and a foreign language teacher in particular, one must first possess a certain variety of skills. It is nevertheless impossible to be a teacher without, in fact, having played the role of one. Therefore, it is important to emphasize the importance of initial education and supervised professional practices that should be carried out during university studies with the intention to prepare and familiarize the Spanish language students with the job of a language teacher. In consequence, the aim of this paper is to investigate the percentage of Spanish teachers in Serbia who have completed professional practices during their studies and how they have prepared for their teaching jobs. Through an anonymous questionnaire and an analysis of a sample of 46 SFL teachers, a general dissatisfaction with the practices is first presented, as well as 40% of them who did not even have the opportunity to perform them. In addition to a shortage of opportunities to practice teaching in the workplace, there is also a lack of initiative and awareness about some volunteer opportunities. Therefore, it is considered significant having expanded the knowledge of the subject, especially since it is imperative that teachers receive both theoretical and practical education. It is believed that both observing classes and participating in the process of creating and planning a class or series of classes are quite necessary, considering that respondents highlighted the relationship with their mentors, their advice, and possibilities for collaboration in activities as the most effective., Para convertirse en un profesor en general, de lenguas extranjeras en particular, se requiere una cierta variedad de habilidades. Pero, sobre todo, no se puede ser profesor sin, en realidad, haber desempeñado el papel de uno. De hecho, es oportuno resaltar la importancia de la formación inicial y de las prácticas profesionales supervisadas que deben llevarse a cabo durante los estudios universitarios para preparar y familiarizar a los estudiantes de lengua española con el oficio de docente. Con este propósito, el objetivo de este trabajo es investigar el porcentaje de profesores de español en Serbia que han realizado prácticas durante sus estudios y cómo se han preparado para sus trabajos como docentes. A través de un cuestionario anónimo y tras analizar la muestra de 46 profesores de ELE, se presenta, en primer lugar, un descontento general con las prácticas realizadas, así como un 40 % de ellos que ni siquiera tuvieron la oportunidad de realizarlas. Asimismo, se manifiesta no solo la escasez de oportunidades de ejercer el oficio docente en el lugar de trabajo, sino también la falta de iniciativa y conocimiento de algunas oportunidades de voluntariado. Se considera, por consiguiente, importante haber ampliado el conocimiento del tema, especialmente porque es imprescindible que los profesores reciban tanto la educación teórica, como la oportunidad de educación práctica. Tanto observar las clases como participar en el proceso de crear y planear una clase o serie de clases se considera necesario, teniendo en cuenta que los encuestados destacaron la relación con sus mentores, sus consejos y posibilidades de colaboración en las actividades como más fructíferos.
- Published
- 2023
48. The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity
- Author
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Popovic, Milica, Schouten, Arie, Rensen-de Leeuw, Marije, and Rehmann, Holger
- Published
- 2016
- Full Text
- View/download PDF
49. THE INFLUENCE OF BEAUTY INFLENCERS ON INSTAGRAM ON THE FEMALE POPULATION IN THE REPUBLIC OF SERBIA: ANALYSIS OF THE PERCEPTIONS OF WOMEN OF DIFFERENT AGE AND EDUCATION.
- Author
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Stojanović, Miloš, Gligorijević, Jasmina, Popović, Milica, and Grubor, Marina
- Subjects
FEMININE beauty (Aesthetics) ,INFLUENCER marketing ,INTERNET marketing ,PSYCHOLOGY of women - Abstract
Modern marketing activities cannot be imagined without a combination of traditional and digital marketing channels, with digital marketing channels gaining more and more importance. Digital marketing channels include a large number of channels, of which the website, social networks, blogs, paid advertising on search engines and mobile marketing are particularly important. Social networks as a digital marketing channel are particularly suitable for influencing consumers. In addition to organic advertising and paid advertising, the engagement of influencers who market informative and interesting content for a specific target group is becoming more and more important. Instagram is a particularly important social network for influencers, due to the presence of a large number of users. The aim of this paper is to investigate the importance of influencer marketing on Instagram to the female population in the beauty industry, but also to identify the factors that influence the importance of influencer marketing in this industry. For this purpose, adequate statistical tests were applied, which showed that in Reublica, Serbia, trust in influencers and the useful content they market are considered particularly important, but also that the credibility and creativity of beauty influencers are exceptionally significant, especially when it comes to more educated women [ABSTRACT FROM AUTHOR]
- Published
- 2023
50. Microwave Spectroscopy of Melanoma Progression Model
- Author
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Tchinov, Rachel, primary, Boparai, Jasmine, additional, Miller, Oliver, additional, Jallouli, Yanis, additional, and Popović, Milica, additional
- Published
- 2023
- Full Text
- View/download PDF
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