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Additional file 1: Supplementary Methods. Adaptation algorithm for spinal radiographic scores. Imputation of missing covariate data. Supplementary Table 1. Multivariable analysis for identification of factors associated with radiographic progression defined as an increase of ≥ 2 mSASSS units per 2 years in the cervical and in the lumbar spine. Supplementary Figure 1. Cumulative probability plot of 2-year progression in the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) by spinal segments, illustrating the change in mSASSS values in patients already treated with TNFi at start of the respective interval, stratified by the ASDAS cut-off level reached at baseline.