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42 results on '"Popova, Anastasiya V."'

5. Correlation of Acinetobacter baumannii K144 and K86 capsular polysaccharide structures with genes at the K locus reveals the involvement of a novel multifunctional rhamnosyltransferase for structural synthesis

Author

Kenyon, Johanna J., Kasimova, Anastasiya A., Sviridova, Anastasiya N., Shpirt, Anna M., Shneider, Mikhail M., Mikhaylova, Yuliya V., Shelenkov, Andrei A., Popova, Anastasiya V., Perepelov, Andrei V., Shashkov, Alexander S., Dmitrenok, Andrei S., Chizov, Alexander O., and Knirel, Yuriy A.

Published
2021
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13. The Acinetobacter baumannii K70 and K9 capsular polysaccharides consist of related K-units linked by the same Wzy polymerase and cleaved by the same phage depolymerases

Author

Kasimova, Anastasiya A., primary, Sharar, Nowshin S., additional, Ambrose, Stephanie J., additional, Knirel, Yuriy A., additional, Shneider, Mikhail M., additional, Timoshina, Olga Y., additional, Popova, Anastasiya V., additional, Perepelov, Andrey V., additional, Dmitrenok, Andrey S., additional, Hsu, Li Yang, additional, Hall, Ruth M., additional, and Kenyon, Johanna J., additional

Published
2023
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19. Loss of a Branch Sugar in the Acinetobacter baumannii K3-Type Capsular Polysaccharide Due To Frameshifts in the gtr6 Glycosyltransferase Gene Leads To Susceptibility To Phage APK37.1

Author

Timoshina, Olga Y., primary, Kasimova, Anastasiya A., additional, Shneider, Mikhail M., additional, Arbatsky, Nikolay P., additional, Shashkov, Alexander S., additional, Shelenkov, Andrey A., additional, Mikhailova, Yuliya V., additional, Popova, Anastasiya V., additional, Hall, Ruth M., additional, Knirel, Yuriy A., additional, and Kenyon, Johanna J., additional

Published
2023
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22. Involvement of a Phage-Encoded Wzy Protein in the Polymerization of K127 Units To Form the Capsular Polysaccharide of Acinetobacter baumannii Isolate 36-1454

Author

Arbatsky, Nikolay P., primary, Kasimova, Anastasiya A., additional, Shashkov, Alexander S., additional, Shneider, Mikhail M., additional, Popova, Anastasiya V., additional, Shagin, Dmitry A., additional, Shelenkov, Andrey A., additional, Mikhailova, Yuliya V., additional, Yanushevich, Yurii G., additional, Hall, Ruth M., additional, Knirel, Yuriy A., additional, and Kenyon, Johanna J., additional

Published
2022
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23. Acinetobacter baumannii K106 and K112: Two Structurally and Genetically Related 6-Deoxy-l-talose-Containing Capsular Polysaccharides

Author

Kasimova, Anastasiya A., primary, Arbatsky, Nikolay P., additional, Tickner, Jacob, additional, Kenyon, Johanna J., additional, Hall, Ruth M., additional, Shneider, Michael M., additional, Dzhaparova, Alina A., additional, Shashkov, Alexander S., additional, Chizhov, Alexander O., additional, Popova, Anastasiya V., additional, and Knirel, Yuriy A., additional

Published
2021
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27. The Modern Textbook as a Laboratory of Creating a Morally Full-Fledged Individual.

Author

Kondratova, Tatiana I., Saltanova, Nadezhda Yu., and Popova, Anastasiya V.

Subjects
MORAL education, CHINESE literature, COMPARATIVE studies, RUSSIAN literature, ONLINE education, TEACHING methods
Abstract

The article presents a concept of creating a textbook on literature for undergraduate Russian-Chinese languages major students, and therefore taking courses of Russian and Chinese literature. The relevance of the present research lies in the necessity to develop the strategy of moral education of the students undergoing professional training. The authors have used the activity-and-competence-building approach; they propose that the textbook should be regarded as a laboratory of creating a person's morality. According to the authors, a full-fledged moral person is an individual who strives for obtaining high moral qualities and who realizes the inconsistency with the ideal. The article demonstrates the samples of educational materials and tasks that will help the reader to come to certain moral conclusions and get a lesson in humanism, team spirit, patriotism, tolerance, etc. The authors show the use of comparative analysis, which creates an idea not only of the proximity of various elements of content and form in Russian and Chinese literature, but also of the similarity of moral criteria in assessing the personal values of two nations. Examples of texts taken from literatures of different countries and various time periods, possessing a certain typological similarity in the range of topics brought up by the writers, - these examples convince us that although ethical criteria, in contrast to moral laws, although they are based on them, but they possess an overtemporal nature, they are eternal, universal. [ABSTRACT FROM AUTHOR]

Published
2021
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28. The K46 and K5 capsular polysaccharides produced by Acinetobacter baumannii NIPH 329 and SDF have related structures and the side-chain non-ulosonic acids are 4-O-acetylated by phage-encoded O-acetyltransferases

Author

Kenyon, Johanna J., primary, Arbatsky, Nikolay P., additional, Shneider, Mikhail M., additional, Popova, Anastasiya V., additional, Dmitrenok, Andrei S., additional, Kasimova, Anastasiya A., additional, Shashkov, Alexander S., additional, Hall, Ruth M., additional, and Knirel, Yuriy A., additional

Published
2019
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35. The KL24 gene cluster and a genomic island encoding a Wzy polymerase contribute genes needed for synthesis of the K24 capsular polysaccharide by the multiply antibiotic resistant Acinetobacter baumannii isolate RCH51

Author

Kenyon, Johanna J, primary, Kasimova, Anastasiya A, additional, Shneider, Mikhail M, additional, Shashkov, Alexander S, additional, Arbatsky, Nikolay P, additional, Popova, Anastasiya V, additional, Miroshnikov, Konstantin A, additional, Hall, Ruth M, additional, and Knirel, Yuriy A, additional

Published
2017
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37. K19 capsular polysaccharide of Acinetobacter baumannii is produced via a Wzy polymerase encoded in a small genomic island rather than the KL19 capsule gene cluster

Author

Kenyon, Johanna J., primary, Shneider, Mikhail M., additional, Senchenkova, Sofya N., additional, Shashkov, Alexander S., additional, Siniagina, Maria N., additional, Malanin, Sergey Y., additional, Popova, Anastasiya V., additional, Miroshnikov, Konstantin A., additional, Hall, Ruth M., additional, and Knirel, Yuriy A., additional

Published
2016
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38. Acinetobacter baumanniiK27 and K44 capsular polysaccharides have the same K unit but different structures due to the presence of distinctwzygenes in otherwise closely related K gene clusters

Author

Shashkov, Alexander S, primary, Kenyon, Johanna J, additional, Senchenkova, Sof'ya N, additional, Shneider, Mikhail M, additional, Popova, Anastasiya V, additional, Arbatsky, Nikolay P, additional, Miroshnikov, Konstantin A, additional, Volozhantsev, Nikolay V, additional, Hall, Ruth M, additional, and Knirel, Yuriy A, additional

Published
2015
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40. Acinetobacter baumannii K27 and K44 capsular polysaccharides have the same K unit but different structures due to the presence of distinct wzy genes in otherwise closely related K gene clusters.

Author

Shashkov, Alexander S., Kenyon, Johanna J., Senchenkova, Sof'ya N., Shneider, Mikhail M., Popova, Anastasiya V., Arbatsky, Nikolay P., Miroshnikov, Konstantin A., Volozhantsev, Nikolay V., Hall, Ruth M., and Knirel, Yuriy A.

Subjects
POLYSACCHARIDES, ACINETOBACTER baumannii, MOLECULAR structure, NUCLEAR magnetic resonance spectroscopy, GLUCOSAMINE, BACTERIAL genes
Abstract

Capsular polysaccharides (CPSs), from Acinetobacter baumannii isolates 1432, 4190 and NIPH 70, which have related gene content at the K locus, were examined, and the chemical structures established using 2D 1H and 13C NMR spectroscopy. The three isolates produce the same pentasaccharide repeat unit, which consists of 5-N-acetyl-7-N-[(S)-3-hydroxybutanoyl] (major) or 5,7-di-N-acetyl (minor) derivatives of 5,7-diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic (legionaminic) acid (Leg5Ac7R), D-galactose, N-acetyl-D-galactosamine and N-acetyl-D-glucosamine. However, the linkage between repeat units in NIPH 70 was different to that in 1432 and 4190, and this significantly alters the CPS structure. The KL27 gene cluster in 4190 and KL44 gene cluster in NIPH 70 are organized identically and contain lga genes for Leg5Ac7R synthesis, genes for the synthesis of the common sugars, as well as an itrA2 initiating transferase and four glycosyltransferases genes. They share high-level nucleotide sequence identity for corresponding genes, but differ in the wzy gene encoding the Wzy polymerase. The Wzy proteins, which have different lengths and share no similarity, would form the unrelated linkages in the K27 and K44 structures. The linkages formed by the four shared glycosyltransferaseswere predicted by comparison with gene clusters that synthesize related structures. These findings unambiguously identify the linkages formed by WzyK27 andWzyK44, and show that the presence of different wzy genes in otherwise closely related K gene clusters changes the structure of the CPS. This may affect its capacity as a protective barrier for A. baumannii. [ABSTRACT FROM AUTHOR]

Published
2016
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42. An Acinetobacter baumannii nasal carriage isolate recovered from an asymptomatic patient in Vietnam is extensively antibiotic resistant and produces a rare K71 type capsule.

Author

Shpirt AM, Harmer CJ, Shashkov AS, Shneider MM, Chizhov AO, Dmitrenok AS, Popova AV, Kasimova AA, Perepelov AV, Knirel YA, Hall RM, and Kenyon JJ

Abstract

Acinetobacter baumannii is a leading cause of multidrug-resistant bacterial infections worldwide, and the capsular polysaccharide (CPS) is a major virulence determinant. A previous study of A. baumannii from intubated and asymptomatic patients admitted to the intensive care unit (ICU) at the Hospital for Tropical Diseases in Ho Chi Minh City in Vietnam revealed multiple lineages with diverse antibiotic resistance profiles and CPS biosynthesis loci. Here, we show that 48_n, an asymptomatic nasal carriage isolate belonging to ST142, is extensively antibiotic resistant and carries acquired resistance determinants accounting for the resistance profile. 48_n carries the novel KL71 CPS biosynthesis locus in the chromosome. The structure of the CPS produced by 48_n was established using 1 H and 13 C nuclear magnetic resonance spectroscopy, including two-dimensional 1 Н, 1 Н COSY, 1 Н, 1 Н TOCSY, 1 Н, 1 Н ROESY, 1 Н, 13 C HSQC, and 1 Н, 13 C HMBC experiments, and confirmed by Smith degradation. Consistent with the genetic content of KL71, the K71 CPS was found to be made up of octasaccharide K units containing six l-rhamnose residues and one residue each of N -acetyl-d-glucosamine and d-glucuronic acid. K71 CPS was branched and closely related to the K74 CPS produced by BAL_309, an antibiotic susceptible ST142 isolate recovered from an intubated patient in the same ICU 7 years later. K71 and K74 differ only in the linkage between K units, and this is due to the replacement of a single gene at the K locus that codes for the Wzy polymerase., Importance: The majority of Acinetobacter baumannii genomes sequenced and analyzed to develop an understanding of extensively drug-resistant (XDR) isolates belong to the globally disseminated CC2 clonal complex. While XDR isolates belonging to rarer lineages are often unexplored, detailed analyses could provide novel insights into the spread of resistance, as well as cell surface features such as the CPS that determine the specificity of non-antibiotic therapeutics required to treat XDR infections that resist antimicrobial chemotherapy. Here, we describe the properties of an XDR asymptomatic nasal carriage isolate recovered in Vietnam that belongs to ST142, a rarely encountered sequence type. We report the resistance profile and correlate this with detected resistance determinants. We also solve the structure of the CPS and reveal its relationship with CPS produced by other A. baumannii isolates.

Published
2024
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