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6. Knockout of Hsp70 genes significantly affects locomotion speed and gene expression in leg skeletal muscles of Drosophila melanogaster.

Author

Makhnovskii, Pavel A., Kukushkina, Inna V., Kurochkina, Nadia S., and Popov, Daniil V.

Subjects
REGULATOR genes, GENE expression, LEG muscles, MEMBRANE proteins, DROSOPHILA melanogaster, PROTEOMICS, HEAT shock proteins
Abstract

The functions of the heat shock protein 70 (Hsp70) genes were studied using a line of Drosophila melanogaster with a knockout of 6 of these genes out of 13. Namely, the effect of knockout of Hsp70 genes on negative geotaxis climbing (locomotor) speed and the ability to adapt to climbing training (0.5–1.5 h/day, 7 days/wk, 19 days) were examined. Seven- and 23-day-old Hsp70− flies demonstrated a comparable reduction (twofold) in locomotor speed and widespread changes in leg skeletal muscle transcriptome (RNA sequencing) compared with w1118 flies. To identify the functions of genes related to decreased locomotor speed, the overlapped differentially expressed genes at both time points were analyzed: the upregulated genes encoded extracellular proteins, regulators of drug metabolism, and the antioxidant response, whereas downregulated genes encoded regulators of carbohydrate metabolism and transmembrane proteins. In addition, in Hsp70− flies, activation of transcription factors related to disruption of the fibril structure and heat shock response (Hsf) was predicted, using the position weight matrix approach. In control flies, adaptation to chronic exercise training was associated mainly with gene response to a single exercise bout, whereas the predicted transcription factors were related to stress/immune (Hsf, NF-κB, etc.) and early gene response. In contrast, Hsp70− flies demonstrated no adaptation to training as well as a significantly impaired gene response to a single exercise bout. In conclusion, the knockout of Hsp70 genes not only reduced physical performance but also disrupted adaptation to chronic physical training, which is associated with changes in the leg skeletal muscle transcriptome and impaired gene response to a single exercise bout. NEW & NOTEWORTHY: Knockout of six heat shock protein 70 (Hsp70) genes in Drosophila melanogaster reduced locomotion (climbing) speed that is associated with genotype-specific differences in leg skeletal muscle gene expression. Disrupted adaptation of Hsp70− flies to chronic exercise training is associated with impaired gene response to a single exercise bout. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Age‐related changes in human skeletal muscle transcriptome and proteome are more affected by chronic inflammation and physical inactivity than primary aging

Author

Kurochkina, Nadia S., primary, Orlova, Mira A., additional, Vigovskiy, Maksim A., additional, Zgoda, Viktor G., additional, Vepkhvadze, Tatiana F., additional, Vavilov, Nikita E., additional, Makhnovskii, Pavel A., additional, Grigorieva, Olga A., additional, Boroday, Yakov R., additional, Philippov, Vladislav V., additional, Lednev, Egor M., additional, Efimenko, Anastasia Yu., additional, and Popov, Daniil V., additional

Published
2024
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12. The association of HFE gene H63D polymorphism with endurance athlete status and aerobic capacity: novel findings and a meta-analysis

Author

Semenova, Ekaterina A., Miyamoto-Mikami, Eri, Akimov, Egor B., Al-Khelaifi, Fatima, Murakami, Haruka, Zempo, Hirofumi, Kostryukova, Elena S., Kulemin, Nikolay A., Larin, Andrey K., Borisov, Oleg V., Miyachi, Motohiko, Popov, Daniil V., Boulygina, Eugenia A., Takaragawa, Mizuki, Kumagai, Hiroshi, Naito, Hisashi, Pushkarev, Vladimir P., Dyatlov, Dmitry A., Lekontsev, Eugene V., Pushkareva, Yuliya E., Andryushchenko, Liliya B., Elrayess, Mohamed A., Generozov, Edward V., Fuku, Noriyuki, and Ahmetov, Ildus I.

Published
2020
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16. Age-related changes in human skeletal muscle transcriptome and proteome are more affected by chronic inflammation and physical inactivity than primary aging

Author

Kurochkina, Nadia S., primary, Orlova, Mira A., additional, Vigovskiy, Maksim A., additional, Vepkhvadze, Tatiana F., additional, Zgoda, Viktor G., additional, Vavilov, Nikita E., additional, Makhnovskii, Pavel A., additional, Grigorieva, Olga A., additional, Boroday, Yakov R., additional, Philippov, Vladislav V., additional, Lednev, Egor M., additional, Efimenko, Anastasia Yu., additional, and Popov, Daniil V., additional

Published
2023
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21. A Genome-Wide Association Study of Sprint Performance in Elite Youth Football Players

Author

Pickering, Craig, Suraci, Bruce, Semenova, Ekaterina A., Boulygina, Eugenia A., Kostryukova, Elena S., Kulemin, Nickolay A., Borisov, Oleg V., Khabibova, Sofya A., Larin, Andrey K., Pavlenko, Alexander V., Lyubaeva, Ekaterina V., Popov, Daniil V., Lysenko, Evgeny A., Vepkhvadze, Tatiana F., Lednev, Egor M., Leońska-Duniec, Agata, Pająk, Beata, Chycki, Jakub, Moska, Waldemar, Lulińska-Kuklik, Ewelina, Dornowski, Marcin, Maszczyk, Adam, Bradley, Ben, Kana-ah, Adam, Cięszczyk, Pawel, Generozov, Edward V., and Ahmetov, Ildus I.

Published
2019
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22. Short communication: On the potential use of materials with heterogeneously distributed parent and daughter isotopes as primary standards for non-U–Pb geochronological applications of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

Author

Popov, Daniil V.

Subjects
General Engineering
Abstract

Many new geochronological applications of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) have been proposed in recent years. One of the problems associated with this rapid growth is the lack of chemically and isotopically homogeneous matrix-matched primary standards to control elemental fractionation during LA-ICP-MS analysis. In U–Pb geochronological applications of LA-ICP-MS this problem is often addressed by utilising matrix-matched primary standards with variable chemical and isotopic compositions. Here I derive a set of equations to adopt this approach for non-U–Pb geochronological applications of LA-ICP-MS.

Published
2022
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23. Three DNA Polymorphisms Previously Identified as Markers for Handgrip Strength Are Associated With Strength in Weightlifters and Muscle Fiber Hypertrophy

Author

Grishina, Elina E., Zmijewski, Piotr, Semenova, Ekaterina A., Cięszczyk, Paweł, Humińska-Lisowska, Kinga, Michałowska-Sawczyn, Monika, Maculewicz, Ewelina, Crewther, Blair, Orysiak, Joanna, Kostryukova, Elena S., Kulemin, Nickolay A., Borisov, Oleg V., Khabibova, Sofya A., Larin, Andrey K., Pavlenko, Alexander V., Lyubaeva, Ekaterina V., Popov, Daniil V., Lysenko, Evgeny A., Vepkhvadze, Tatiana F., Lednev, Egor M., Bondareva, Elvira A., Erskine, Robert M., Generozov, Edward V., and Ahmetov, Ildus I.

Published
2019
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25. The A-allele of the FTO Gene rs9939609 Polymorphism Is Associated With Decreased Proportion of Slow Oxidative Muscle Fibers and Over-represented in Heavier Athletes

Author

Guilherme, João Paulo L.F., Egorova, Emiliya S., Semenova, Ekaterina A., Kostryukova, Elena S., Kulemin, Nickolay A., Borisov, Oleg V., Khabibova, Sofya A., Larin, Andrey K., Ospanova, Elena A., Pavlenko, Alexander V., Lyubaeva, Ekaterina V., Popov, Daniil V., Lysenko, Evgeny A., Vepkhvadze, Tatiana F., Lednev, Egor M., Govorun, Vadim M., Generozov, Edward V., Ahmetov, Ildus I., and Lancha Junior, Antonio H.

Published
2019
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29. Additional file 1 of Alternative transcription start sites contribute to acute-stress-induced transcriptome response in human skeletal muscle

Author

Makhnovskii, Pavel A., Gusev, Oleg A., Bokov, Roman O., Gazizova, Guzel R., Vepkhvadze, Tatiana F., Lysenko, Evgeny A., Vinogradova, Olga L., Kolpakov, Fedor A., and Popov, Daniil V.

Abstract

Additional file 1. Figure S1. Design of the study. A. Ten endurance-trained athletes carried out an intermittent exercise on a cycle ergometer. Intensity of exercise was selected based on an incremental cycling test till exhaustion. Biopsy samples were taken from the m. vastus lateralis prior to, 2 min, 1 h, 3 h, and 6 h after an intermittent exercise (1st, 2d, and 3d from the one leg, 4st and 5st from another leg). B. An intermittent exercise induced metabolic shift indicated by markedly elevated blood lactate concentration. Figure S2. GO enrichment analysis for biological processes induced by acute exercise. The heat map shows the P-value adjusted (Padj). Dark red and blue denotes the most significant GO terms for up. The count indicates the number of genes enriched into a term. Figure S3.Distribution of nucleosome-depleted region markers around the CAGE TSS. The density of transcription factor binding sites (TFBSs) on the DNA (data from 15,982 ChIP-seq experiments; above), mean normalized DNase-seq and ATAC-seq signals (middle) and probability of open chromatin distribution (below) evaluated by normalized signals and MACS2 peaks for DNase-seq and ATAC-seq data, respectively (4 skeletal muscle samples).

Published
2022
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36. Numerical Modelling of Radiogenic Ingrowth and Diffusion of Pb in Apatite Inclusions with Variable Shape and U-Th Zonation

Author

Popov, Daniil V. and Spikings, Richard A.

Subjects
flux-limited, lcsh:Mineralogy, lcsh:QE351-399.2, inclusion, apatite, open, diffusion, U-Th-Pb, thermochronology, Pb, boundary
Abstract

The fundamental premise of apatite U-Th-Pb thermochronology is that radiogenic Pb is redistributed by volume diffusion. In practice, it is often additionally assumed that crystals (1) lose radiogenic Pb to an infinite reservoir, (2) have a simple geometry and (3) are chemically homogeneous. Here we explore the significance of the latter three assumptions by numerical modelling of Pb radiogenic ingrowth and diffusion in apatite inclusions within other minerals. Our results indicate that the host minerals are likely to hamper diffusive Pb loss from the apatite inclusions by limiting the Pb flux across their boundaries, and thus the thermal histories that are reconstructed assuming a fully open boundary may be significantly inaccurate, precluding a meaningful interpretation. We also find that when apatite boundaries are flux-limited, heterogeneities in U and Th concertation within apatite have subordinate effect on bulk-grain U-Th-Pb dates and can cause intra-grain U-Th-Pb dates to increase towards the boundaries. Finally, we show that it is important to correctly account for crystal geometry when modelling intra-grain U-Th-Pb dates. We suggest that the effect of surrounding minerals on diffusive Pb loss from apatite (and loss of other radiogenic isotopes from other minerals) should be examined more closely in future research.

Published
2021
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37. AGTR2 gene polymorphism is associated with muscle fibre composition, athletic status and aerobic performance

Author

Mustafina, Leysan J., Naumov, Vladimir A., Cieszczyk, Pawel, Popov, Daniil V., Lyubaeva, Ekaterina V., Kostryukova, Elena S., Fedotovskaya, Olga N., Druzhevskaya, Anastasiya M., Astratenkova, Irina V., Glotov, Andrey S., Alexeev, Dmitry G., Mustafina, Milyausha M., Egorova, Emiliya S., Maciejewska-Karłowska, Agnieszka, Larin, Andrey K., Generozov, Edward V., Nurullin, Ruslan E., Jastrzębski, Zbigniew, Kulemin, Nickolay A., Ospanova, Elena A., Pavlenko, Alexander V., Sawczuk, Marek, Akimov, Egor B., Danilushkina, Anna A., Żmijewski, Piotr, Vinogradova, Olga L., Govorun, Vadim M., and Ahmetov, Ildus I.

Published
2014
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44. Prediction of muscle fiber composition using multiple repetition testing

Author

Hall, Elliott C.R., primary, Lysenko, Evgeny A, additional, Semenova, Ekaterina A., additional, Borisov, Oleg V., additional, Andryushchenko, Oleg N., additional, Andryushchenko, Liliya B., additional, Vepkhvadze, Tatiana F, additional, Lednev, Egor M., additional, Zmijewski, Piotr, additional, Popov, Daniil V, additional, Generozov, Edward V., additional, and Ahmetov, Ildus I, additional

Published
2021
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46. Diffusion and fluid interaction in Itrongay pegmatite (Madagascar): Evidence from in situ 40Ar/39Ar dating of gem-quality alkali feldspar and U Pb dating of protogenetic apatite inclusions

Author

Popov, Daniil V., primary, Spikings, Richard A., additional, Scaillet, Stéphane, additional, O'Sullivan, Gary, additional, Chew, David, additional, Badenszki, Eszter, additional, Daly, J. Stephen, additional, Razakamanana, Théodore, additional, and Davies, Joshua H.F.L., additional

Published
2020
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47. Branched-chain amino acids administration suppresses endurance exercise-related activation of ubiquitin proteasome signaling in trained human skeletal muscle

Author

Lysenko, Evgeny A., Vepkhvadze, Tatiana F., Lednev, Egor M., Vinogradova, Olga L., and Popov, Daniil V.

Subjects
Exercise, Branched chain amino acids, Proteolysis, Ubiquitin, Protein biosynthesis, Aprotinin, RNA, Muscles, Psychology and mental health
Abstract

We tested whether post exercise ingestion of branched-chain amino acids (BCAA < 10 g) is sufficient to activate signaling associated with muscle protein synthesis and suppress exercise-induced activation of mechanisms associated with proteolysis in endurance-trained human skeletal muscle. Nine endurance-trained athletes performed a cycling bout with and without BCAA ingestion (0.1 g/kg). Post exercise ACC.sup.Ser79/222 phosphorylation (endogenous marker of AMPK activity) was increased (~3-fold, P < 0.05) in both sessions. No changes were observed in IGF1 mRNA isoform expression or phosphorylation of the key anabolic markers -- p70S6K1.sup.Thr389 and eEF2.sup.Thr56 -- between the sessions. BCAA administration suppressed exercise-induced expression of mTORC1 inhibitor DDIT4 mRNA, eliminated activation of the ubiquitin proteasome system, detected in the control session as decreased FOXO1.sup.Ser256 phosphorylation (0.83-fold change, P < 0.05) and increased TRIM63 (MURF1) expression (2.4-fold, P < 0.05). Therefore, in endurance-trained human skeletal muscle, post exercise BCAA ingestion partially suppresses exercise-induced expression of PGC-1a mRNA, activation of ubiquitin proteasome signaling, and suppresses DDIT4 mRNA expression. Keywords: Endurance exercise, Branched-chain amino acids, Proteolysis, Mitochondrial biogenesis, Author(s): Evgeny A. Lysenko[sup.1,2], Tatiana F. Vepkhvadze[sup.1], Egor M. Lednev[sup.2], Olga L. Vinogradova[sup.1,2] and Daniil V. Popov[sup.1,2] Introduction Endurance training leads to increased skeletal muscle oxidative capacity, mitochondrial volume density, [...]

Published
2016
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48. The association of HFE gene H63D polymorphism with endurance athlete status and

Author

Semenova, Ekaterina A, Miyamoto-Mikami, Eri, Akimov, Egor B, Al-Khelaifi, Fatima, Murakami, Haruka, Zempo, Hirofumi, Kostryukova, Elena S, Kulemin, Nikolay A, Larin, Andrey K, Borisov, Oleg V, Miyachi, Motohiko, Popov, Daniil V, Boulygina, Eugenia A, Takaragawa, Mizuki, Kumagai, Hiroshi, Naito, Hisashi, Pushkarev, Vladimir P, Dyatlov, Dmitry A, Lekontsev, Eugene V, Pushkareva, Yuliya E, Andryushchenko, Liliya B, Elrayess, Mohamed A, Generozov, Edward V, Fuku, Noriyuki, and Ahmetov, Ildus I

Abstract

P(論文), https://www.tsc-05.ac.jp/pdf_library/2021.pdf

Published
2021

49. Striated muscle-specific serine/threonine-protein kinase beta segregates with high versus low responsiveness to endurance exercise training

Author

Kusić, Denis, primary, Connolly, Joanne, additional, Kainulainen, Heikki, additional, Semenova, Ekaterina A., additional, Borisov, Oleg V., additional, Larin, Andrey K., additional, Popov, Daniil V., additional, Generozov, Edward V., additional, Ahmetov, Ildus I., additional, Britton, Steven L., additional, Koch, Lauren G., additional, and Burniston, Jatin G., additional

Published
2020
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50. UBR5 is a novel E3 ubiquitin ligase involved in skeletal muscle hypertrophy and recovery from atrophy

Author

Seaborne, Robert A., primary, Hughes, David C., additional, Turner, Daniel C., additional, Owens, Daniel J., additional, Baehr, Leslie M., additional, Gorski, Piotr, additional, Semenova, Ekaterina A., additional, Borisov, Oleg V., additional, Larin, Andrey K., additional, Popov, Daniil V., additional, Generozov, Edward V., additional, Sutherland, Hazel, additional, Ahmetov, Ildus I., additional, Jarvis, Jonathan C., additional, Bodine, Sue C., additional, and Sharples, Adam P., additional

Published
2019
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