Search

A common problem in many cities is the continual growth in the number of personal vehicles, which creates numerous challenges and impacts on the environment, the local economy and, most importantly, on the communities and individuals who live and work in these areas. This increase in traffic brings to the forefront issues such as road congestion, air pollution, longer journey times and damage to existing road infrastructure. The aim of this paper is to investigate and analyze the impact of the increase in the number of personal vehicles on traffic and road infrastructure in the student complex of Timisoara. By studying this problem, possible solutions and measures were identified to effectively address these challenges and improve the quality of life of the residents in the area.

Introduction: Diabetes mellitus (DM) has a millennia-long history, with early references dating back to ancient Egypt and India. However, it was not until the 20th century that the connection between diabetes and insulin was fully understood. The sequencing of insulin in the 1950s initiated the convergence of biotechnology and diabetes management, leading to the development of recombinant human insulin in 1982. This marked the start of peptide-based therapies in DM. Recombinant peptides for DM treatment: Numerous recombinant peptides have been developed since, starting with modified insulin molecules, with the aim of bettering DM management through fine-tuning the glycemic response to insulin. Peptide-based therapies in DM have expanded substantially beyond insulin to include agonists of Glucagon-like peptide-1 receptor and Glucose-dependent insulinotropic polypeptide receptor, glucagon receptor antagonists, and even peptides exerting multiple receptor agonist effects, for better metabolic control. Insulin pumps, continuous glucose monitoring, and automated insulin delivery systems: The development of modern delivery systems combined with real-time glucose monitoring has significantly advanced diabetes care. Insulin pumps evolved from early large devices to modern sensor-augmented pumps with automated shutoff features and hybrid closed-loop systems, requiring minimal user input. The second-generation systems have demonstrated superior outcomes, proving highly effective in diabetes management. Islet cell transplantation, organoids, and biological pancreas augmentation represent innovative approaches to diabetes management. Islet cell transplantation aims to restore insulin production by transplanting donor beta cells, though challenges persist regarding graft survival and the need for immunosuppression. Organoids are a promising platform for generating insulin-producing cells, although far from clinical use. Biological pancreas augmentation relies on therapies that promote beta-cell (re)generation, reduce stress, and induce immune tolerance. Further biotechnology-driven perspectives in DM will include metabolic control via biotechnology-enabled tools such as custom-designed insulin hybrid molecules, machine-learning algorithms to control peptide release, and engineering cells for optimal peptide production and secretion. [ABSTRACT FROM AUTHOR]

Background and Objectives: Heart failure is associated with high morbidity and mortality and linked with several pre-existing health conditions and risk factors. Early detection and prompt management in heart failure improves patient outcomes. Liver involvement is associated with heart failure disease progression, and hence liver biomarkers and liver fibrosis may have a prognostic impact. Several blood test based markers and scoring systems estimate liver fibrosis and hence can be useful prognostic tools. Materials and Methods: We retrospectively analyzed a series of 303 patients with decompensated heart failure in a city in western Romania over a period of 6 months. Several biochemical parameters were measured, the FIB-4 score was estimated and echocardiography was performed. Results for targeted variables are presented using descriptive statistics. Patients were analyzed based on their LVEF categories. Statistical analysis was based on ANOVA one-way tests for continuous variables and Chi-square tests for categorical variables. Pairwise comparisons were performed based on Bonferroni adjusted significance tests. The correlations between FIB-4 score, LVEF and NT-pro BNP in patients with and without diabetes and hypertension were explored using Spearman's correlation coefficient. Result: Age, gender, NYHA class, death, history of (h/o) type 2 diabetes mellitus (T2DM), h/o coronary artery disease (CAD), h/o arrhythmias, sodium, potassium, creatinine, eGFR, uric acid, NT-pro BNP, left atrial volume, LDL, HDL, and TG were analyzed by LVEF categories using ANOVA one-way tests, Chi-square tests, and Bonferroni correction comparisons. We found a strong statistically significant correlation between each of NT-pro BNP, left atrial volume, LDL, and HDL with the LVEF categories. Discussion: Early detection of cardiac dysfunction leads to better management in patients with cardiovascular risk factors including diabetes and hypertension. High LDL and low HDL levels contribute to a reduction in left ventricular (LV) function. Available literature suggests the FIB-4 score as superior to other non-invasive markers of fibrosis. It utilizes the patient's age, platelet count, AST, and ALT, which can be available retrospectively, making it an easy and inexpensive tool. FIB-4 score has a few limitations. Conclusions: Our study has shown a statistically significant positive correlation between severity categories of LVEF and FIB-4 score for heart failure patients with and without diabetes, and for heart failure patients with or without hypertension. We propose the implementation of FIB-4 score as a prognostic tool for heart failure. [ABSTRACT FROM AUTHOR]

Postnatal depression is still a largely unknown phenomenon, even in the 21st century, for the new mother, her husband, and her family, and even more concerning, sometimes by medical staff who do not recognize the signs and symptoms of this condition to provide help, guidance, and support to the new mother. As a result, unfortunately, there are still mothers who, even today, face these experiences and feelings caused by the transformation of pregnancy on their own, without fully understanding what is happening to them and their bodies. This phenomenon can have significant negative effects on the child, the mother, and her family, both in the short and long term. There are numerous risk factors that can contribute to the onset of this depression; however, the primary objective of this paper is to highlight the main risk factors that have emerged from my study regarding the onset of postpartum depression and to emphasize the importance of family support to prevent or mitigate this condition as much as possible for the new mother. [ABSTRACT FROM AUTHOR]

Introduction: Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder characterized by significant autoantibodies, particularly targeting nuclear antigens. SLE pathogenesis involves genetic, environmental, and hormonal factors. The disease course includes flares and remission and involves various organs. Recent therapeutic progresses, including biologics, have improved management and prognosis, though the long-term impact of novel therapies remains to be determined. Biologics in SLE: Rituximab, the earliest B-cell-oriented biologic, binds CD20 and depletes CD20+ B cells, leading to remission in some SLE patients. Belimumab is a B-cell-activating factor (BAFF) inhibitor with a recent additional indication for lupus nephritis. The CALIBRATE and BLISS-BELIEVE studies investigated combinations of these drugs with conventional therapies, showing varied efficacy. Ocrelizumab and obinutuzumab, newer CD20-oriented SLE therapies, together with ofatumumab and veltuzumab, are also promising. The latest trials highlight their efficacy and safety. Anifrolumab, targeting type-I interferon receptors, was evaluated in the TULIP 1/2 trials. The ongoing TULIP LTE trial supports the long-term safety and efficacy of anifrolumab. Additionally, the IRIS Phase III trial is exploring anifrolumab for lupus nephritis, showing favorable renal responses. Tocilizumab and secukinumab are being assessed for SLE, with mixed outcomes. Several biologics targeting the C5 complement protein, together with immunomodulators and immunotherapeutics, are also under investigation for potential benefits in SLE. Discussion: Biologics in SLE target specific immune components, aiming to improve disease control and reduce the side effects of conventional therapy. However, trial outcomes vary due to factors like inclusion criteria and trial design. Conclusions: Biotechnology progress enables targeted biologic therapies for SLE, reducing disease activity and improving patients' quality of life. [ABSTRACT FROM AUTHOR]

In this study we consider correlated and simultaneous interventions regarding: i—the physical infrastructure (by crossover lines between the two tracks of a tram line), ii—the characteristics of the trams (by bi-directional trams), as well as iii—tactical and operative decisions of the line manager. How these interventions are reflected in the functional reliability of the tram line service is demonstrated for both cases of the current operation and for the case of overloads, respectively, for the case of the temporary degradation of circulation caused by random disruptive events. The theoretical analysis, generalizing findings regarding the effectiveness of solutions to improve functional reliability, is supplemented with quantitative evaluations related to certain situations of disruptions. The proposed solutions aim to increase the attractiveness of urban public transport. Even if the evaluations are focused mainly on the interests of the service quality perceived by the user, the beneficial consequences for the line manager (in terms of technical and commercial efficiency) are also addressed. [ABSTRACT FROM AUTHOR]

Cropping system diversification is a key factor in developing more sustainable crops and increase food security. A two-year field experiment was conducted at South-East part of Romania, to emphasize the right plant types, both legumes and non-legumes which can be used in intercropping system for organic agriculture. Intercropping pattern with two (Peas + Camelina; Peas + Flax; Peas + Oats; Flax + Oats; Spring Wheat + Camelina and Spring Wheat + Flax) and three species (Peas + Camelina + Spring Wheat; Peas + Flax + Spring wheat; Peas + Flax + Oats; Peas + Camelina + Oats) was used. Sole cropping of peas, camelina, flax, oats and spring wheat were also used. Two sowing rates were tested, at 50% and 100% of the recommended amount of seed. Results showed that averaged across years and intercropping patterns, yields were significantly more increased in mixtures crops compared to sole cropping ones. Through the land equalization ratio (LER) with values greater than 1, the mixtures of crops (of two or three species) that use environmental resources more efficiently and productively were identified. [ABSTRACT FROM AUTHOR]

Metro network systems play an important role in urban transportation but they are vulnerable to various risks and disruptions. Having a comprehensive understanding of these risks is essential for their operation. In this paper, we aimed to assess the operational robustness of the Bucharest metro system. We employed graph theory and concepts. Using available data specific to the Bucharest metro system operation, we analyzed the type of disruptions across metro lines and stations. As expected, the two subway lines that sub-cross the city center experienced the greatest number of disruptions. Several stations on Line M1, that sub-cross the central urban area, were found to be particularly vulnerable. In our analysis, the results are as follows: the robustness indicator for the metro network, rT, is 0.1538, and the effective graph conductance (CG) is 0.1. These reveal that the Bucharest metro network can withstand up to 45% of node failures before collapsing. This indicates moderate robustness, suggesting that while the network can handle specific disruptions, targeted improvements are necessary to enhance overall resilience. [ABSTRACT FROM AUTHOR]