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3. Clinical presentation and antimicrobial resistance of invasive Escherichia coli disease in hospitalized older adults: a prospective multinational observational study

Author

Doua, Joachim, Rodríguez-Baño, Jesús, Froget, Rachel, Puranam, Padma, Go, Oscar, Geurtsen, Jeroen, van Rooij, Sanne, Vilken, Tuba, Minoru, Inage, Yasumori, Izumi, Spiessens, Bart, Tacconelli, Evelina, Biehl, Lena M., Thaden, Joshua T., Sarnecki, Michal, Goossens, Herman, Poolman, Jan, Bonten, Marc, and Ekkelenkamp, Miquel

Published
2024
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7. A microbiological and genomic perspective of globally collected Escherichia coli from adults hospitalized with invasive E. coli disease

Author

Epi Infectieziekten, Infection & Immunity, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectious Diseases, Epi Infectieziekten Team 1, MMB Medische Staf, Arconada Nuin, Enya, Vilken, Tuba, Xavier, Basil Britto, Doua, Joachim, Morrow, Brian, Geurtsen, Jeroen, Go, Oscar, Spiessens, Bart, Sarnecki, Michal, Poolman, Jan, Bonten, Marc, Ekkelenkamp, Miquel, Lammens, Christine, Goossens, Herman, Glupczynski, Youri, Van Puyvelde, Sandra, COMBACTE-NET Consortium/EXPECT Study Group, Epi Infectieziekten, Infection & Immunity, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectious Diseases, Epi Infectieziekten Team 1, MMB Medische Staf, Arconada Nuin, Enya, Vilken, Tuba, Xavier, Basil Britto, Doua, Joachim, Morrow, Brian, Geurtsen, Jeroen, Go, Oscar, Spiessens, Bart, Sarnecki, Michal, Poolman, Jan, Bonten, Marc, Ekkelenkamp, Miquel, Lammens, Christine, Goossens, Herman, Glupczynski, Youri, Van Puyvelde, Sandra, and COMBACTE-NET Consortium/EXPECT Study Group

Published
2024

8. A microbiological and genomic perspective of globally collected Escherichia coli from adults hospitalized with invasive E. coli disease.

Author

Nuin, Enya Arconada, Vilken, Tuba, Xavier, Basil Britto, Doua, Joachim, Morrow, Brian, Geurtsen, Jeroen, Go, Oscar, Spiessens, Bart, Sarnecki, Michal, Poolman, Jan, Bonten, Marc, Ekkelenkamp, Miquel, Lammens, Christine, Goossens, Herman, Glupczynski, Youri, Puyvelde, Sandra Van, and Group, COMBACTE-NET Consortium/EXPECT Study

Subjects
ESCHERICHIA coli, URINARY tract infections, MICROBIAL sensitivity tests, OLDER people, BACTERIAL population
Abstract

Objectives Escherichia coli can cause infections in the urinary tract and in normally sterile body sites leading to invasive E. coli disease (IED), including bacteraemia and sepsis, with older populations at increased risk. We aimed to estimate the theoretical coverage rate by the ExPEC4V and 9V vaccine candidates. In addition, we aimed at better understanding the diversity of E. coli isolates, including their genetic and phenotypic antimicrobial resistance (AMR), sequence types (STs), O-serotypes and the bacterial population structure. Methods Blood and urine culture E. coli isolates (n  = 304) were collected from hospitalized patients ≥60 years (n = 238) with IED during a multicentric, observational study across three continents. All isolates were tested for antimicrobial susceptibility, O-serotyped, whole-genome sequenced and bioinformatically analysed. Results A large diversity of STs and of O-serotypes were identified across all centres, with O25b-ST131, O6-ST73 and O1-ST95 being the most prevalent types. A total of 45.4% and 64.7% of all isolates were found to have an O-serotype covered by the ExPEC4V and ExPEC9V vaccine candidates, respectively. The overall frequency of MDR was 37.4% and ST131 was predominant among MDR isolates. Low in-patient genetic variability was observed in cases where multiple isolates were collected from the same patient. Conclusions Our results highlight the predominance of MDR O25b-ST131 E. coli isolates across diverse geographic areas. These findings provide further baseline data on the theoretical coverage of novel vaccines targeting E. coli associated with IED in older adults and their associated AMR levels. [ABSTRACT FROM AUTHOR]

Published
2024
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11. 2465. O-serotype Distribution of Escherichia coli Causing Invasive Disease in Tertiary Care Hospital Patients

Author

Geurtsen, Jeroen, primary, Doua, Joachim, additional, Martinez-Martinez, Luis, additional, de Palacios, Patricia Ibarra, additional, Powis, Jeff, additional, Sims, Matthew, additional, Hermans, Peter, additional, Barraud, Oliver, additional, Lanotte, Philippe, additional, Thaden, Joshua T, additional, Go, Oscar, additional, Spiessens, Bart, additional, Abbanat, Darren, additional, Wagenlehner, Florian, additional, Matsumoto, Tetsuya, additional, Bonten, Marc, additional, Sarnecki, Michal, additional, and Poolman, Jan, additional

Published
2023
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12. Safety, Reactogenicity, Immunogenicity, and Dose Selection of 10-Valent Extraintestinal Pathogenic Escherichia coli Bioconjugate Vaccine (VAC52416) in Adults Aged 60–85 Years in a Randomized, Multicenter, Interventional, First-in-Human, Phase 1/2a Study

Author

Fierro, Carlos A, primary, Sarnecki, Michal, additional, Doua, Joachim, additional, Spiessens, Bart, additional, Go, Oscar, additional, Davies, Todd A, additional, van den Dobbelsteen, Germie, additional, Poolman, Jan, additional, Abbanat, Darren, additional, and Haazen, Wouter, additional

Published
2023
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13. Safety, immunogenicity, and preliminary clinical efficacy of a vaccine against extraintestinal pathogenic Escherichia coli in women with a history of recurrent urinary tract infection: a randomised, single-blind, placebo-controlled phase 1b trial

Author

Huttner, Angela, Hatz, Christoph, van den Dobbelsteen, Germie, Abbanat, Darren, Hornacek, Alena, Frölich, Rahel, Dreyer, Anita M, Martin, Patricia, Davies, Todd, Fae, Kellen, van den Nieuwenhof, Ingrid, Thoelen, Stefan, de Vallière, Serge, Kuhn, Anette, Bernasconi, Enos, Viereck, Volker, Kavvadias, Tilemachos, Kling, Kerstin, Ryu, Gloria, Hülder, Tanja, Gröger, Sabine, Scheiner, David, Alaimo, Cristina, Harbarth, Stephan, Poolman, Jan, and Fonck, Veronica Gambillara

Published
2017
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17. Global Distribution of O Serotypes and Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli Collected From the Blood of Patients With Bacteremia Across Multiple Surveillance Studies

Author

Weerdenburg, Eveline, Davies, Todd, Morrow, Brian, Zomer, Aldert L, Hermans, Peter, Go, Oscar, Spiessens, Bart, van den Hoven, Thijs, van Geet, Gunter, Aitabi, Moussa, DebRoy, Chitrita, Dudley, Edward G, Bonten, Marc, Poolman, Jan, Geurtsen, Jeroen, Weerdenburg, Eveline, Davies, Todd, Morrow, Brian, Zomer, Aldert L, Hermans, Peter, Go, Oscar, Spiessens, Bart, van den Hoven, Thijs, van Geet, Gunter, Aitabi, Moussa, DebRoy, Chitrita, Dudley, Edward G, Bonten, Marc, Poolman, Jan, and Geurtsen, Jeroen

Abstract

Background: Extraintestinal pathogenic Escherichia coli (ExPEC) is the leading cause of bacteremia worldwide, with older populations having increased risk of invasive bacterial disease. Increasing resistance to first-line antibiotics and emergence of multidrug-resistant (MDR) strains represent major treatment challenges. ExPEC O serotypes are key targets for potential multivalent conjugate vaccine development. Therefore, we evaluated the O serotype distribution and antibiotic resistance profiles of ExPEC strains causing bloodstream infections across 4 regions. Methods: Blood culture isolates from patients aged ≥60 years collected during 5 retrospective E. coli surveillance studies in Europe, North America, Asia-Pacific, and South America (2011-2017) were analyzed. Isolates were O serotyped by agglutination; O genotyping was performed for nontypeable isolates. Antimicrobial susceptibility testing was also conducted. Results: Among 3217 ExPEC blood culture isolates, the most ubiquitous O serotype was O25 (n = 737 [22.9%]), followed by O2, O6, O1, O75, O15, O8, O16, O4, O18, O77 group, O153, O9, O101/O162, O86, and O13 (prevalence of ≥1%). The prevalence of these O serotypes was generally consistent across regions, apart from South America; together, these 16 O serotypes represented 77.6% of all ExPEC bacteremia isolates analyzed. The overall MDR frequency was 10.7%, with limited variation between regions. Within the MDR subset (n = 345), O25 showed a dominant prevalence of 63.2% (n = 218). Conclusions: Predominant O serotypes among ExPEC bacteremia isolates are widespread across different regions. O25 was the most prevalent O serotype overall and particularly dominant among MDR isolates. These findings may inform the design of multivalent conjugate vaccines that can target the predominant O serotypes associated with invasive ExPEC disease in older adults.

Published
2023

18. Global Distribution of O Serotypes and Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli Collected From the Blood of Patients With Bacteremia Across Multiple Surveillance Studies

Author

Klinische infectiologie en microb. lab., dI&I I&I-4, Infectious Diseases and Immunology - KLIF, Weerdenburg, Eveline, Davies, Todd, Morrow, Brian, Zomer, Aldert L, Hermans, Peter, Go, Oscar, Spiessens, Bart, van den Hoven, Thijs, van Geet, Gunter, Aitabi, Moussa, DebRoy, Chitrita, Dudley, Edward G, Bonten, Marc, Poolman, Jan, Geurtsen, Jeroen, Klinische infectiologie en microb. lab., dI&I I&I-4, Infectious Diseases and Immunology - KLIF, Weerdenburg, Eveline, Davies, Todd, Morrow, Brian, Zomer, Aldert L, Hermans, Peter, Go, Oscar, Spiessens, Bart, van den Hoven, Thijs, van Geet, Gunter, Aitabi, Moussa, DebRoy, Chitrita, Dudley, Edward G, Bonten, Marc, Poolman, Jan, and Geurtsen, Jeroen

Published
2023

19. Epidemiology, Clinical Features, and Antimicrobial Resistance of Invasive Escherichia Coli Disease in Patients Admitted in Tertiary Care Hospitals

Author

Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, Doua, Joachim, Geurtsen, Jeroen, Rodriguez-Baño, Jesus, Cornely, Oliver A, Go, Oscar, Gomila-Grange, Aina, Kirby, Andrew, Hermans, Peter, Gori, Andrea, Zuccaro, Valentina, Gravenstein, Stefan, Bonten, Marc, Poolman, Jan, Sarnecki, Michal, Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, Doua, Joachim, Geurtsen, Jeroen, Rodriguez-Baño, Jesus, Cornely, Oliver A, Go, Oscar, Gomila-Grange, Aina, Kirby, Andrew, Hermans, Peter, Gori, Andrea, Zuccaro, Valentina, Gravenstein, Stefan, Bonten, Marc, Poolman, Jan, and Sarnecki, Michal

Published
2023

20. Global Distribution of O Serotypes and Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli Collected From the Blood of Patients With Bacteremia Across Multiple Surveillance Studies

Author

Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten Team 1, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, Weerdenburg, Eveline, Davies, Todd, Morrow, Brian, Zomer, Aldert L, Hermans, Peter, Go, Oscar, Spiessens, Bart, van den Hoven, Thijs, van Geet, Gunter, Aitabi, Moussa, DebRoy, Chitrita, Dudley, Edward G, Bonten, Marc, Poolman, Jan, Geurtsen, Jeroen, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten Team 1, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, Weerdenburg, Eveline, Davies, Todd, Morrow, Brian, Zomer, Aldert L, Hermans, Peter, Go, Oscar, Spiessens, Bart, van den Hoven, Thijs, van Geet, Gunter, Aitabi, Moussa, DebRoy, Chitrita, Dudley, Edward G, Bonten, Marc, Poolman, Jan, and Geurtsen, Jeroen

Published
2023

21. Epidemiology, Clinical Features, and Antimicrobial Resistance of Invasive Escherichia Coli Disease in Patients Admitted in Tertiary Care Hospitals

Author

Janssen Research and Development, Doua, Joachim, Geurtsen, Jeroen, Rodríguez-Baño, Jesús, Cornely, Oliver A., Go, Oscar, Gomila-Grange, Aina, Kirby, Andrew, Hermans, Peter, Gori, Andrea, Zuccaro, Valentina, Gravenstein, Stefan, Bonten, Marc, Poolman, Jan, Sarnecki, Michal, on behalf of the BAC0006 Study Group as instructed by the Study Steering Committee, Janssen Research and Development, Doua, Joachim, Geurtsen, Jeroen, Rodríguez-Baño, Jesús, Cornely, Oliver A., Go, Oscar, Gomila-Grange, Aina, Kirby, Andrew, Hermans, Peter, Gori, Andrea, Zuccaro, Valentina, Gravenstein, Stefan, Bonten, Marc, Poolman, Jan, Sarnecki, Michal, and on behalf of the BAC0006 Study Group as instructed by the Study Steering Committee

Abstract

[Background] Invasive Escherichia coli disease (IED), including bloodstream infection, sepsis, and septic shock, can lead to high hospitalization and mortality rates. This multinational study describes the clinical profile of patients with IED in tertiary care hospitals., [Methods] We applied clinical criteria of systemic inflammatory response syndrome (SIRS), sepsis, or septic shock to patients hospitalized with culture-confirmed E coli from urine or a presumed sterile site. We assessed a proposed clinical case definition against physician diagnoses., [Results] Most patients with IED (N = 902) were adults aged ≥60 years (76.5%); 51.9%, 25.1%, and 23.0% of cases were community-acquired (CA), hospital-acquired (HA), and healthcare-associated (HCA), respectively. The urinary tract was the most common source of infection (52.3%). Systemic inflammatory response syndrome, sepsis, and septic shock were identified in 77.4%, 65.3%, and 14.1% of patients, respectively. Patients >60 years were more likely to exhibit organ dysfunction than those ≤60 years; this trend was not observed for SIRS. The case-fatality rate (CFR) was 20.0% (60–75 years, 21.5%; ≥75 years, 22.2%), with an increase across IED acquisition settings (HA, 28.3%; HCA, 21.7%; CA, 15.2%). Noticeably, 77.8% of patients initiated antibiotic use on the day of culture sample collection. A total of 65.6% and 40.8% of E coli isolates were resistant to ≥1 agent in ≥1 or ≥2 drug class(es). A 96.1% agreement was seen between the proposed clinical case definition and physician's diagnoses of IED., [Conclusions] This study contributes valuable, real-world data about IED severity. An accepted case definition could promote timely and accurate diagnosis of IED and inform the development of novel preventative strategies.

Published
2023

26. Epidemiology, Clinical Features, and Antimicrobial Resistance of Invasive Escherichia Coli Disease in Patients Admitted in Tertiary Care Hospitals

Author

Doua, Joachim, primary, Geurtsen, Jeroen, additional, Rodriguez-Baño, Jesus, additional, Cornely, Oliver A, additional, Go, Oscar, additional, Gomila-Grange, Aina, additional, Kirby, Andrew, additional, Hermans, Peter, additional, Gori, Andrea, additional, Zuccaro, Valentina, additional, Gravenstein, Stefan, additional, Bonten, Marc, additional, Poolman, Jan, additional, and Sarnecki, Michal, additional

Published
2023
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28. Genomics and pathotypes of the many faces of Escherichia coli

Author

Geurtsen, Jeroen, de Been, Mark, Weerdenburg, Eveline, Zomer, Aldert, McNally, Alan, Poolman, Jan, Klinische infectiologie en microb. lab., and dI&I I&I-4

Subjects
Infectious Diseases, Escherichia coli pathotypes, population dynamics, virulence factors, bacterial species, Microbiology, accessory genome, antibiotic resistance
Abstract

Escherichia coli is the most researched microbial organism in the world. Its varied impact on human health, consisting of commensalism, gastrointestinal disease, or extraintestinal pathologies, has generated a separation of the species into at least eleven pathotypes (also known as pathovars). These are broadly split into two groups, intestinal pathogenic E. coli (InPEC) and extraintestinal pathogenic E. coli (ExPEC). However, components of E. coli's infinite open accessory genome are horizontally transferred with substantial frequency, creating pathogenic hybrid strains that defy a clear pathotype designation. Here, we take a birds-eye view of the E. coli species, characterizing it from historical, clinical, and genetic perspectives. We examine the wide spectrum of human disease caused by E. coli, the genome content of the bacterium, and its propensity to acquire, exchange, and maintain antibiotic resistance genes and virulence traits. Our portrayal of the species also discusses elements that have shaped its overall population structure and summarizes the current state of vaccine development targeted at the most frequent E. coli pathovars. In our conclusions, we advocate streamlining efforts for clinical reporting of ExPEC, and emphasize the pathogenic potential that exists throughout the entire species.

Published
2022

30. 120. Safety, Reactogenicity, and Immunogenicity of Three Different Doses of VAC52416 (ExPEC10V) in Adults Aged 60–85 Years in a Randomized, Multicenter, Interventional, First-In-Human, Phase 1/2a Study

Author

Doua, Joachim, primary, Fierro, Carlos, additional, Sarnecki, Michal, additional, Spiessens, Bart, additional, Go, Oscar, additional, Davies, Todd, additional, van den Dobbelsteen, Germie, additional, Poolman, Jan, additional, and Haazen, Wouter, additional

Published
2022
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31. 1823. Clinical Profile and Antimicrobial Susceptibility of Invasive Extraintestinal Pathogenic Escherichia coli Disease in Hospitalized Adults Aged ≥60 Years

Author

Doua, Joachim, primary, Baño, Jesús Rodriguez, additional, Geurtsen, Jeroen, additional, Go, Oscar, additional, Sarnecki, Michal, additional, Vilken, Tuba, additional, Spiessens, Bart, additional, Vallejo, Christine, additional, Goossens, Herman, additional, Bonten, Marc, additional, Poolman, Jan, additional, and Ekkelenkamp, Miquel, additional

Published
2022
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34. Genomics and pathotypes of the many faces ofEscherichia coli

Author

Geurtsen, Jeroen, de Been, Mark, Weerdenburg, Eveline, Zomer, Aldert, McNally, Alan, Poolman, Jan, Klinische infectiologie en microb. lab., and dI&I I&I-4

Subjects
antibiotic resistance, Extraintestinal Pathogenic Escherichia coli, Virulence Factors, Escherichia coli Proteins, Escherichia coli pathotypes, Genomics, accessory genome, Microbiology, accessory genome, antibiotic resistance, Infectious Diseases, population dynamics, Escherichia coli, Humans, bacterial species, Escherichia coli Infections, Phylogeny
Abstract

Escherichia coli is the most researched microbial organism in the world. Its varied impact on human health, consisting of commensalism, gastrointestinal disease, or extraintestinal pathologies, has generated a separation of the species into at least eleven pathotypes (also known as pathovars). These are broadly split into two groups, intestinal pathogenic E. coli (InPEC) and extraintestinal pathogenic E. coli (ExPEC). However, components of E. coli’s infinite open accessory genome are horizontally transferred with substantial frequency, creating pathogenic hybrid strains that defy a clear pathotype designation. Here, we take a birds-eye view of the E. coli species, characterizing it from historical, clinical, and genetic perspectives. We examine the wide spectrum of human disease caused by E. coli, the genome content of the bacterium, and its propensity to acquire, exchange, and maintain antibiotic resistance genes and virulence traits. Our portrayal of the species also discusses elements that have shaped its overall population structure and summarizes the current state of vaccine development targeted at the most frequent E. coli pathovars. In our conclusions, we advocate streamlining efforts for clinical reporting of ExPEC, and emphasize the pathogenic potential that exists throughout the entire species.

Published
2022
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35. Genomics and pathotypes of the many faces of Escherichia coli

Author

Klinische infectiologie en microb. lab., dI&I I&I-4, Geurtsen, Jeroen, de Been, Mark, Weerdenburg, Eveline, Zomer, Aldert, McNally, Alan, Poolman, Jan, Klinische infectiologie en microb. lab., dI&I I&I-4, Geurtsen, Jeroen, de Been, Mark, Weerdenburg, Eveline, Zomer, Aldert, McNally, Alan, and Poolman, Jan

Published
2022

36. Colonization with Escherichia coli ST131- H 30R (H 30R) Corresponds with Increased Serum Anti-O25 IgG Levels and Decreased TNFα and IL-10 Responsiveness to H 30R.

Author

Johnston, Brian D., Clabots, Connie, Bender, Tricia, Porter, Stephen B., van den Dobbelsteen, Germie, Poolman, Jan, Thuras, Paul, and Johnson, James R.

Subjects
BACTERIAL colonies, IMMUNOGLOBULIN G, INTERLEUKIN-10, ESCHERICHIA coli, ENZYME-linked immunosorbent assay
Abstract

An exceptional gut-colonizing ability may underlie the dramatic epidemiological success of the multidrug-resistant H30R subclone of Escherichia coli sequence type 131 (O25b:K+:H4). In order to inform the development of colonization-preventing measures, we studied systemic immune correlates of H30R intestinal colonization. Human volunteers' fecal samples were screened for H30R by selective culture and PCR. Subjects were assessed by enzyme immunoassay for serum levels of anti-O25 IgG (representing H30R) and anti-O6 IgG (representing non-H30 E. coli generally), initially and for up to 14 months. Whole blood was tested for the antigen-stimulated release of IFNγ, TNFα, IL-4, IL-10, and IL-17 after incubation with E. coli strains JJ1886 (H30R; O25b:K+:H4) or CFT073 (non-H30; O6:K2:H1). Three main findings were obtained. First, H30R-colonized subjects had significantly higher anti-O25 IgG levels than controls, but similar anti-O6 IgG levels, suggesting an IgG response to H30R colonization. Second, anti-O25 and anti-O6 IgG levels were stable over time. Third, H30R-colonized subjects exhibited a lower TNFα and IL-10 release than controls in response to strain JJ1886 (H30R) relative to strain CFT073 (non-H30R), consistent with TNFα hypo-responsiveness to H30R possibly predisposing to H30R colonization. Thus, H30R-colonized hosts exhibit a sustained serum anti-O25 IgG response and an underlying deficit in TNFα responsiveness to H30R that could potentially be addressed for colonization prevention. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Global Distribution of O Serotypes and Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli Collected From the Blood of Patients With Bacteremia Across Multiple Surveillance Studies

Author

Weerdenburg, Eveline, primary, Davies, Todd, additional, Morrow, Brian, additional, Zomer, Aldert L, additional, Hermans, Peter, additional, Go, Oscar, additional, Spiessens, Bart, additional, van den Hoven, Thijs, additional, van Geet, Gunter, additional, Aitabi, Moussa, additional, DebRoy, Chitrita, additional, Dudley, Edward G, additional, Bonten, Marc, additional, Poolman, Jan, additional, and Geurtsen, Jeroen, additional

Published
2022
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41. Description and nomenclature of Neisseria meningitidis capsule locus

Author

Harrison, Odile B., Claus, Heike, Jiang, Ying, Bennett, Julia S., Bratcher, Holly B., Jolley, Keith A., Corton, Craig, Care, Rory, Poolman, Jan T., Zollinger, Wendell D., Frasch, Carl E., Stephens, David S., Feavers, Ian, Frosch, Matthias, Parkhill, Julian, Vogel, Ulrich, Quail, Michael A., Bentley, Stephen D., and Maiden, Martin C.J.

Subjects
Neisseria meningitidis -- Identification and classification -- Health aspects -- Genetic aspects -- Research, Nuclear magnetic resonance spectroscopy -- Usage -- Health aspects, Polymerase chain reaction -- Usage, Health
Abstract

Thirteen Neisseria meningitidis serogroups have been described on the basis of serologic differences of the capsule; of these 13 serogroups, 6 (A, B, C, W, X, Y) cause invasive meningococcal [...]

Published
2013
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43. Reply by Authors

Author

Epi Infectieziekten, MMB, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten Team 1, Rosenberg, Steven, Bonten, Marc, Haazen, Wouter, Spiessens, Bart, Abbanat, Darren, Go, Oscar, Wagenlehner, Florian, Shore, Neal, Hagiwara, Yosuke, Ibarra de Palacios, Patricia, Geurtsen, Jeroen, Hermans, Peter, Poolman, Jan, Epi Infectieziekten, MMB, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten Team 1, Rosenberg, Steven, Bonten, Marc, Haazen, Wouter, Spiessens, Bart, Abbanat, Darren, Go, Oscar, Wagenlehner, Florian, Shore, Neal, Hagiwara, Yosuke, Ibarra de Palacios, Patricia, Geurtsen, Jeroen, Hermans, Peter, and Poolman, Jan

Published
2021

44. Epidemiology and O-Serotypes of Extraintestinal Pathogenic Escherichia coli Disease in Patients Undergoing Transrectal Ultrasound Prostate Biopsy: A Prospective Multicenter Study

Author

Communicatie, UMC Utrecht Holding, Epi Infectieziekten, MMB, Infection & Immunity, JC onderzoeksprogramma Infectious Diseases, Epi Infectieziekten Team 1, Rosenberg, Steven, Bonten, Marc, Haazen, Wouter, Spiessens, Bart, Abbanat, Darren, Go, Oscar, Wagenlehner, Florian, Shore, Neal, Hagiwara, Yosuke, Ibarra de Palacios, Patricia, Geurtsen, Jeroen, Hermans, Peter, Poolman, Jan, Communicatie, UMC Utrecht Holding, Epi Infectieziekten, MMB, Infection & Immunity, JC onderzoeksprogramma Infectious Diseases, Epi Infectieziekten Team 1, Rosenberg, Steven, Bonten, Marc, Haazen, Wouter, Spiessens, Bart, Abbanat, Darren, Go, Oscar, Wagenlehner, Florian, Shore, Neal, Hagiwara, Yosuke, Ibarra de Palacios, Patricia, Geurtsen, Jeroen, Hermans, Peter, and Poolman, Jan

Published
2021

45. Reply to Baird and Douglas

Author

Epi Infectieziekten, MMB, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Bonten, Marc, Verstraeten, Thomas, Gravenstein, Stefan, Poolman, Jan, Epi Infectieziekten, MMB, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Bonten, Marc, Verstraeten, Thomas, Gravenstein, Stefan, and Poolman, Jan

Published
2021

46. Epidemiology of Escherichia coli Bacteremia: A Systematic Literature Review

Author

Epi Infectieziekten, MMB, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Bonten, Marc, Johnson, James R, van den Biggelaar, Anita H J, Georgalis, Leonidas, Geurtsen, Jeroen, de Palacios, Patricia Ibarra, Gravenstein, Stefan, Verstraeten, Thomas, Hermans, Peter, Poolman, Jan T, Epi Infectieziekten, MMB, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Bonten, Marc, Johnson, James R, van den Biggelaar, Anita H J, Georgalis, Leonidas, Geurtsen, Jeroen, de Palacios, Patricia Ibarra, Gravenstein, Stefan, Verstraeten, Thomas, Hermans, Peter, and Poolman, Jan T

Published
2021

50. Vaccination With Detoxified Leukocidin AB Reduces Bacterial Load in a Staphylococcus aureus Minipig Deep Surgical Wound Infection Model

Author

Fernandez, Jeffrey, primary, Sanders, Holly, additional, Henn, Jessica, additional, Wilson, Jolaine M, additional, Malone, Danielle, additional, Buoninfante, Alessandra, additional, Willms, Matthew, additional, Chan, Rita, additional, DuMont, Ashley L, additional, McLahan, Craig, additional, Grubb, Kaitlyn, additional, Romanello, Anthony, additional, van den Dobbelsteen, Germie, additional, Torres, Victor J, additional, and Poolman, Jan T, additional

Published
2021
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