Search

Your search keyword '"Poole, Victoria"' showing total 168 results
Start Over Author "Poole, Victoria"
168 results on '"Poole, Victoria"'

3. Alterations in Structural Correlation Networks with Prior Concussion in Collision-Sport Athletes

Author

Sadiq, Muhammad Usman, Svaldi, Diana, Shenk, Trey, Breedlove, Evan, Poole, Victoria, Tamer, Greg, Abbas, Kausar, and Talavage, Thomas

Subjects
Quantitative Biology - Quantitative Methods, Computer Science - Neural and Evolutionary Computing, Quantitative Biology - Neurons and Cognition
Abstract

Several studies have used structural correlation networks, derived from anatomical covariance of brain regions, to analyze neurologic changes associated with multiple sclerosis, schizophrenia and breast cancer [1][2]. Graph-theoretical analyses of human brain structural networks have consistently shown the characteristic of small-worldness that reflects a network with both high segregation and high integration. A large neuroimaging literature on football players, with and without history of concussion, has shown both functional and anatomical changes. Here we use graph-based topological properties of anatomical correlation networks to study the effect of prior concussion in collision-sport athletes. 40 high school collision-sport athletes (23 male football, 17 female soccer; CSA) without self-reported history of concussion (HOC-), 18 athletes (13 male football, 5 female soccer) with self-reported history of concussion (HOC+) and 24 healthy controls (19 male, 5 female; CN) participated in imaging sessions before the beginning of a competition season. The extracted residual volumes for each group were used for building the correlation networks and their small-worldness, , is calculated. The small-worldness of CSA without prior history of concussion, , is significantly greater than that of controls, . CSA with prior history have significantly higher (vs. 95% confidence interval) small-worldness compared to HOC+, over a range of network densities. The longer path lengths in HOC+ group could indicate disrupted neuronal integration relative to healthy controls.

Published
2019

5. Cerebral arteriolosclerosis, lacunar infarcts, and cognition in older Black adults.

Author

Fleischman, Debra A., Arfanakis, Konstantinos, Leurgans, Sue E., Arvanitakis, Zoe, Lamar, Melissa, Han, S. Duke, Poole, Victoria N., Bennett, David A., and Barnes, Lisa L.

Abstract

INTRODUCTION: Older Black adults are at risk of cerebral small vessel disease (CSVD), which contributes to dementia risk. Two subtypes of CSVD, arteriolosclerosis and ischemic lacunar infarcts, have been independently linked to lower cognition and higher dementia risk, but their combined effects on cognition in older Black adults are unclear. METHODS: Mixed models were used to examine the associations of in vivo measures of arteriolosclerosis (ARTS) and ischemic lacunar infarcts to cognitive level and change in 370 older Black adults without dementia. RESULTS: Modeled together, higher ARTS load accounted for lower levels of global cognition, episodic memory, semantic memory, and perceptual speed, whereas higher infarct load accounted for lower levels of working memory. There were no associations with rate of cognitive change. DISCUSSION: Both arteriolosclerosis and ischemic infarcts impact the cognitive health of older Black adults, but arteriolosclerosis affects cognition more broadly and offers promise as an in vivo biomarker of dementia risk. Highlights: Older Black adults are at risk of cerebral small vessel disease (CSVD) and dementia.Examined magnetic resonance imaging‐derived measure of arteriolosclerosis (ARTS), infarcts, and cognition.ARTS load was widely associated with lower cognition after adjusting for infarct load.Infarct load was specifically associated with lower complex attention.More within‐Black in vivo studies of CSVD subtypes and cognition are needed. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

10. Changes in an in-vivo classifier of ARTerioloSclerosis (ARTS) with simultaneous change in cognition for older African Americans

Author

Lamar, Melissa, primary, Arfanakis, Konstantinos, additional, Evia, Arnold, additional, Makkinejad, Nazanin, additional, Capuano, Ana W., additional, Kim, Namhee, additional, Leurgans., Sue E., additional, Fleischman, Debra A., additional, Duke Han, S, additional, Poole, Victoria, additional, and Barnes, Lisa L., additional

Published
2023
Full Text
View/download PDF

24. Bootstrap approach for meta-synthesis of MRI findings from multiple scanners

Author

Kim, Namhee, primary, Arfanakis, Konstantinos, additional, Leurgans, Sue E., additional, Yang, Jingyun, additional, Fleischman, Debra A., additional, Han, S. Duke, additional, Aggarwal, Neelum T., additional, Lamar, Melissa, additional, Yu, Lei, additional, Poole, Victoria N., additional, Bennett, David A., additional, and Barnes, Lisa L., additional

Published
2021
Full Text
View/download PDF

33. Every hit matters: White matter diffusivity changes in high school football athletes are correlated with repetitive head acceleration event exposure

Author

Jang, Ikbeom, primary, Chun, Il Yong, additional, Brosch, Jared R., additional, Bari, Sumra, additional, Zou, Yukai, additional, Cummiskey, Brian R., additional, Lee, Taylor A., additional, Lycke, Roy J., additional, Poole, Victoria N., additional, Shenk, Trey E., additional, Svaldi, Diana O., additional, Tamer, Gregory G., additional, Dydak, Ulrike, additional, Leverenz, Larry J., additional, Nauman, Eric A., additional, and Talavage, Thomas M., additional

Published
2019
Full Text
View/download PDF

35. Multiscale Dynamics of Spontaneous Brain Activity Is Associated With Walking Speed in Older Adults.

Author

Zhou, Junhong, Poole, Victoria, Wooten, Thomas, Lo, On-Yee, Iloputaife, Ikechukwu, Manor, Brad, Esterman, Michael, and Lipsitz, Lewis A

Subjects
*WALKING speed, *OLDER people, *CORPUS callosum, *FUNCTIONAL magnetic resonance imaging, *TIME series analysis
Abstract

Background: In older adults, compromised white matter tract integrity within the brain has been linked to impairments in mobility. We contend that poorer integrity disrupts mobility by altering the processing of sensorimotor and cognitive and attentional resources in neural networks. The richness of information processing in a given network can be quantified by calculating the complexity of resting-state functional MRI time series. We hypothesized that (i) older adults with lower brain complexity, specifically within sensorimotor, executive, and attention networks, would exhibit slower walking speed and greater dual-task costs (ie, dual-task cost) and (ii) such complexity would mediate the effect of white matter integrity on these metrics of mobility.Methods: Fifty-three older adults completed a walking assessment and a neuroimaging protocol. Brain complexity was quantified by calculating the multiscale entropy of the resting-state functional MRI signal within seven previously defined functional networks. The white matter integrity across structures of the corpus callosum was quantified using fractional anisotropy.Results: Participants with lower resting-state complexity within the sensorimotor, executive, and attention networks walked more slowly under single- and dual-task (ie, walking while performing a serial-subtraction task) conditions (β > 0.28, p ≤ .01) and had a greater dual-task cost (β < -0.28, p < .04). Complexity in these networks mediated the influence of the corpus callosum genu on both single- (indirect effects > 0.15, 95% confidence intervals = 0.02-0.32) and dual-task walking speeds (indirect effects > 0.13, 95% confidence intervals = 0.02-0.33).Conclusion: These results suggest that the multiscale dynamics of resting-state brain activity correlate with mobility and mediate the effect of the microstructural integrity in the corpus callosum genu on walking speed in older adults. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

44. Executive Network Activation is Linked to Walking Speed in Older Adults: Functional MRI and TCD Ultrasound Evidence From the MOBILIZE Boston Study.

Author

Jor'dan, Azizah J., Poole, Victoria N., Iloputaife, Ikechukwu, Milberg, William, Manor, Brad, Esterman, Michael, and Lipsitz, Lewis A.

Subjects
*CEREBRAL circulation, *BLOOD circulation, *TRANSCRANIAL Doppler ultrasonography, *NEURAL circuitry, *BRAIN, *MAGNETIC resonance imaging, *NERVOUS system, *RESEARCH funding, *EXECUTIVE function
Abstract

Background: Changes in cerebral blood flow velocity (CBF) in response to a cognitive task (task-related ΔCBF) have been shown by Transcranial Doppler ultrasonography (TCD) to be reduced in slow walkers. However, it is unknown whether reduced task-related ΔCBF is associated with reduced neural activity in specific brain regions, as measured by blood-oxygen-level dependent (BOLD) functional magnetic resonance imaging (fMRI).Methods: We assessed the regional changes in neural activity associated with reduced middle cerebral artery (MCA) task-related ΔCBF to an executive task and slow walking speed in 67 community-dwelling older adults from the MOBILIZE Boston Study. Participants underwent walking assessments and TCD ultrasonography measures of MCA ΔCBF during the n-back task of executive function. A subset of participants (n = 27) completed the same task during fMRI. Individual BOLD activation maps for the n-back task were correlated with TCD measures and network-level averages were associated with TCD and preferred walking speed.Results: Participants with diminished task-related ΔCBF walked more slowly (β = .39, p = .001). fMRI revealed significant associations between task-related ΔCBF and regional BOLD activation in several brain regions/networks supplied by the MCA. Of these regions and networks, those within the executive network were most strongly associated with walking speed (β = .36, p = .01).Conclusions: Task-related ΔCBF during an executive function task is related to activation in several neural networks and impairment in the ability to recruit the executive network in particular is associated with slow walking speed in older adults. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

50. Detecting Neurocognitive and Neurophysiological Changes as a Result of Subconcussive Blows Among High School Football Athletes

Author

Breedlove, Katherine Morigaki, primary, Breedlove, Evan L., additional, Robinson, Meghan, additional, Poole, Victoria N., additional, King, Jeffrey R., additional, Rosenberger, Paul, additional, Rasmussen, Matthew, additional, Talavage, Thomas M., additional, Leverenz, Larry J., additional, and Nauman, Eric A., additional

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results