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Background: NAFLD ranges from simple fatty liver to non-alcoholic steatohepatitis, which may progress to liver fibrosis, cirrhosis and hepatocellular carcinoma. Subclinical hypothyroidism is associated with metabolic syndrome, cardiovascular mortality and disturbance of lipid metabolism. Objective: To study the association between NAFLD and hypothyroidism. Methods: A cross-sectional study was conducted at a tertiary hospital on 100 adult non-obese hypothyroid patients. Patients were categorised as per their thyroid profile as: Euthyroidism [(TSH): 0.4-4.0µIU/L with normal FT4], Subclinical hypothyroidism (TSH ≥4.1µIU/L with normal FT4), Overt hypothyroidism (TSH ≥4.1µIU/L and FT4

Background: Majority of the AIDS patients will get opportunistic infections due to their low immune system and as result, these opportunistic infections incurs sever health issue among the HIV patients. Methods: The study was conducted on 370 immunocompromised patients selected from government civil hospital ART centre, Vijayapur district Karnataka. Results: majority 302(81.6%) had CD4 count less than 500 cell/ mm3.Metabolic disorder ,PPD and Photosend were considered to be significant opportunist infections and were significant correlation with CD4 count of the patients. Conclusion: It was concluded that some of the opportunistic infections such as metabolic disorder, PPD and photosend was highly correlated with CD4 count among the autoimmunocompromised patients.

Introduction: COVID-19 is an infectious disease caused by the SARS-CoV-2 virus that commonly involved the respiratory system. However, the virus can affect any organ in the body including the liver. Hepatic involvement in COVID-19 could be related to the direct cytopathic effect of the virus, an uncontrolled immune reaction, sepsis, or drug-induced liver injury. Objective: The current study aims to evaluate the relevance of liver enzyme derangement in COVID-19. Methods: The sample size of 165 patients, tested positive for covid 19 and underwent liver enzyme testing. These patients were categorized into mild, severe, and critical diseases based on clinical evaluation, radiological findings, and biochemical parameters. Results: Of 165 patients selected 103 (62.4%) have mild disease, 40(24.2%) have severe and 12(7.2%) suffered from the critical disease. 48(29.1%) patients show deranged liver function. 83.3% of critical patients and 45% of severe patients show deranged liver function.9.09 %of patients died due to severe COVID – 19 infections showing moderately to severe liver function derangement. Conclusions: This study concludes that the severity of COVID-19 disease may increase due to chronic liver disease, particularly fatty liver. Atypical ALT and AST levels during hospitalization were indicative of liver injury and correlated with the severity of patients.