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35 results on '"Pontoriero D."'

4. Diagnosis and treatment of SL ligament injuries

Author

Ioppolo D., Grassi M., FAMA', Carmelo, Fabiano L., Stagno d’Alcontres F., Fazio A., CALAPAI, Marco, Pappalardo M., Pontoriero D., and Ioppolo D., Grassi M., Famà C., Fabiano L., Stagno d’Alcontres F., Fazio A., Calapai M., Pappalardo M., Pontoriero D.

Subjects
SL ligament injuries, treatment, diagnosis
Published
2011

5. EXPRESSION OF SIRTUINS AND BDNF, AND SIRT1-BDNF CORRELATION IN HUMAN ASTROCYTOMAS OF DIFFERENT GRADE

Author

Aguennouz, M'Hammed, Pontoriero, D, Rajan, Ts, Macaione, Vincenzo, Romeo, S, Migliorato, A, Conti, Alfredo, Torre, Dl, Luca, Gd, Vita, Giuseppe, Tomasello, Francesco, Giorgio, Rmd, AGUENNOUZ, M'hammed, Pontoriero D, Rajan TS, MACAIONE, Vincenzo, Romeo S, Migliorato A, CONTI, Alfredo, Torre DL, Luca GD, VITA, Giuseppe, TOMASELLO, Francesco, and Giorgio RMD

Subjects
not available
Published
2011

10. In-Depth Oral Presentations, Oral Communications and Residents’ Oral Communications

Author

Pontoriero, D., D'Andrea, Letterio, Ciccolo, F., Coglitore, F., Miccichè, L., Foti, A., Sessa, M. A. Rosa V., Celentano, U., Ruggeri, A., Rosa, M. A. Rosa M. A., Maccauro, G., De Santis, V., Barreca, S., Orlando, G., Topa, C. Fabbriciani G., Ditto, P., Sileci, G., Vazzana, P., Accardo, M., and Rosa, Michele Attilio

Subjects
medicine.medical_specialty, business.industry, Radiological weapon, Orthopedic surgery, medicine, Surgery, Orthopedics and Sports Medicine, Large diameter, business, 13 November 2012, Hip replacement (animal)
Published
2012

18. Gene expression profile in human astroglial tumors

Author

Aguennouz, M'Hammed, LA TORRE, Domenico, Conti, Alfredo, Tomasello, C., Macaione, Vincenzo, De Pasquale, M. G., Pontoriero, D., De Luca, G., DI GIORGIO, Rosa Maria, Vita, Giuseppe, and Tomasello, F.

Published
2009

32. Disrupting the transmembrane domain-mediated oligomerization of protein tyrosine phosphatase receptor J inhibits EGFR-driven cancer cell phenotypes.

Author

Bloch E, Sikorski EL, Pontoriero D, Day EK, Berger BW, Lazzara MJ, and Thévenin D

Subjects
Cell Line, Tumor, Humans, Immunoblotting, Phosphorylation physiology, Receptor-Like Protein Tyrosine Phosphatases, Class 3 metabolism, Signal Transduction physiology, Spectrometry, Fluorescence, ErbB Receptors metabolism, Receptor Protein-Tyrosine Kinases metabolism
Abstract

Receptor protein tyrosine phosphatases (RPTPs) play critical regulatory roles in mammalian signal transduction. However, the structural basis for the regulation of their catalytic activity is not fully understood, and RPTPs are generally not therapeutically targetable. This knowledge gap is partially due to the lack of known natural ligands or selective agonists of RPTPs. Contrary to what is known from structure-function studies of receptor tyrosine kinases (RTKs), RPTP activities have been reported to be suppressed by dimerization, which may prevent RPTPs from accessing their RTK substrates. We report here that homodimerization of protein tyrosine phosphatase receptor J (PTPRJ, also known as DEP-1) is regulated by specific transmembrane (TM) residues. We found that disrupting these interactions destabilizes homodimerization of full-length PTPRJ in cells, reduces the phosphorylation of the known PTPRJ substrate epidermal growth factor receptor (EGFR) and of other downstream signaling effectors, antagonizes EGFR-driven cell phenotypes, and promotes substrate access. We demonstrate these observations in human cancer cells using mutational studies and identified a peptide that binds to the PTPRJ TM domain and represents the first example of an allosteric agonist of RPTPs. The results of our study provide fundamental structural and functional insights into how PTPRJ activity is tuned by TM interactions in cells. Our findings also open up opportunities for developing peptide-based agents that could be used as tools to probe RPTPs' signaling mechanisms or to manage cancers driven by RTK signaling., (© 2019 Bloch et al.)

Published
2019
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33. [What shall I eat today? Survey about dietary habits of infants and toddlers in Valsesia].

Author

Bertone A, Brossa L, Campra D, Pontoriero D, and Guala A

Subjects
Child, Preschool, Female, Humans, Infant, Italy, Male, Culture, Diet, Habits, Surveys and Questionnaires
Abstract

In April 2002 a survey was conducted about dietary habits of infants and toddlers attending kindergartens in Valsesia, through dietary journal compilation. From 149 answers (response rate = 70%) the results are: a limited vegetables consumption, with a potatoes excess and a legumes scarcity; only one half of children eats fruits daily; consumption of ham and cheese is higher than other proteinic foods; foods variety is weak and the menu is often repetitive in lunch and dinner.

Published
2003

34. [Transient neonatal hypocalcemia. Onset Manifestation of the 22q11.2 deletion syndrome].

Author

Pusceddu M, Bertone A, Campra D, Pontoriero D, and Guala A

Subjects
Chromosome Deletion, Chromosomes, Human, Pair 22 genetics, Craniofacial Abnormalities diagnosis, Craniofacial Abnormalities genetics, DiGeorge Syndrome genetics, Diagnosis, Differential, Heart Defects, Congenital diagnosis, Heart Defects, Congenital genetics, Humans, Hypocalcemia genetics, Hypoparathyroidism genetics, Infant, Infant, Newborn, Male, DiGeorge Syndrome diagnosis, Hypocalcemia diagnosis, Hypoparathyroidism diagnosis
Published
2002

35. [Neonatal thrombosis of the middle cerebral artery].

Author

Campra D, Bertone A, Pontoriero D, Pusceddu M, and Guala A

Subjects
Female, Hemiplegia rehabilitation, Humans, Infant, Newborn, Infarction, Middle Cerebral Artery rehabilitation, Hemiplegia etiology, Infarction, Middle Cerebral Artery complications
Published
2002

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