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11. Gaps and Controversies in Catatonia as a Movement Disorder.

Author

Lenka, Abhishek, Perera, Vishal M., Espay, Alberto J., Pontone, Gregory M., and Okun, Michael S.

Abstract

The term "catatonia" was introduced by German psychiatrist Karl Kahlbaum in 1874. Although historically tied to schizophrenia, catatonia exhibits a diverse range of phenotypes and has been observed in various medical and neuropsychiatric conditions. Its intrinsic movement characteristics and association with hypokinetic and hyperkinetic phenomenologies place catatonia within the purview of movement disorders. Despite the presence of catatonia in psychiatry literature for over 150 years, many gaps and controversies persist regarding its etiopathogenesis, phenomenology, diagnostic criteria, and treatment. The current versions of the International Classification of Diseases (ICD‐11) and the Diagnostic and Statistical Manual of Mental Disorders (DSM‐5) require clinicians to identify any three signs of 15 (ICD‐11) or 12 (DSM‐5) for the diagnosis of catatonia. Catalepsy and waxy flexibility are the only motor features with high specificity for the diagnosis. We highlight the gaps and controversies in catatonia as a movement disorder, emphasize the lack of a clear definition, and discuss the inconsistencies in the description of various catatonic signs. We propose the exploration of a bi‐axial classification framework similar to that used for dystonia and tremor to encourage the evaluation of underlying etiologies and to guide therapeutic decisions to improve the outcome of these patients. © 2024 International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Brainstem Pathologies Correlate With Depression and Psychosis in Parkinson's Disease

Author

Fischer, Nicole Mercado, Hinkle, Jared T., Perepezko, Kate, Bakker, Catherine C., Morris, Meaghan, Broen, Martinus P.G., Butala, Ankur, Dawson, Ted M., Leentjens, Albert F.G., Mari, Zoltan, Marvel, Cherie L., Mills, Kelly A., Rosenthal, Liana S., Shepard, Melissa D., Pantelyat, Alexander, Bakker, Arnold, Pletnikova, Olga, Troncoso, Juan C., Wang, Jiangxia, and Pontone, Gregory M.

Published
2021
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20. Minor Phenomena in Parkinson's Disease–Prevalence, Associations, and Risk of Developing Psychosis.

Author

Schneider, Ruth B., Auinger, Peggy, Dobkin, Roseanne D., Mills, Kelly A., Kulick-Soper, Catherine V., Myers, Taylor L., Korell, Monica, Pontone, Gregory M., and Nirenberg, Melissa J.

Subjects
APATHY, PARKINSON'S disease, MOVEMENT disorders, PSYCHOSES, RAPID eye movement sleep, SLEEP disorders
Abstract

Background: Minor phenomena, including passage phenomena, feeling of presence, and illusions, are common and may represent a prodromal form of psychosis in Parkinson's disease (PD). We examined the prevalence and clinical correlates of minor phenomena, and their potential role as a risk factor for PD psychosis. Methods: A novel questionnaire, the Psychosis and Mild Perceptual Disturbances Questionnaire for PD (PMPDQ), was completed by Fox Insight cohort participants with and without PD. Additional assessments included the Non-Motor Symptoms Questionnaire (NMSQuest), REM Sleep Behavior Disorder Single Question Screen (RBD1Q), Movement Disorder Society-Unified Parkinson Disease Rating Scale Part II, demographic features, and medication usage. For participants with PD, we used regression models to identify clinical associations and predictors of incident psychosis over one year of follow-up. Results: Among participants with PD (n = 5950) and without PD (n = 1879), the prevalence of minor phenomena was 43.1% and 31.7% (P <.001). Of the 3760 participants with PD and no baseline psychosis, independent correlates of minor phenomena included positive responses on the NMSQuest apathy/attention/memory (OR 1.7, 95% CI 1.3-2.1, P <.001) or sexual function domain (OR 1.3, 95% CI 1.1-1.6, P =.01) and positive RBD1Q (OR 1.3, 95% CI 1.05-1.5, P =.01). Independent risk factors for incident PD psychosis included the presence of minor phenomena (HR 3.0, 95% CI 2.4-3.9, P <.001), positive response on the NMSQuest apathy/attention/memory domain (HR 1.8, 95% CI 1.3-2.6, P <.001), and positive RBD1Q (HR 1.5, 95% CI 1.1-1.9, P =.004). Conclusions: Minor phenomena are common, associated with specific non-motor symptoms, and an independent predictor of incident psychosis in PD. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Markers of impaired motor and cognitive volition in Parkinson's disease: Correlates of dopamine dysregulation syndrome, impulse control disorder, and dyskinesias

Author

Hinkle, Jared T., Perepezko, Kate, Rosenthal, Liana S., Mills, Kelly A., Pantelyat, Alexander, Mari, Zoltan, Tochen, Laura, Bang, Jee Yun, Gudavalli, Medha, Yoritomo, Nadine, Butala, Ankur, Bakker, Catherine C., Johnson, Vanessa, Moukheiber, Emile, Dawson, Ted M., and Pontone, Gregory M.

Published
2018
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25. Author Correction: Report from a multidisciplinary meeting on anxiety as a non-motor manifestation of Parkinson’s disease

Author

Pontone, Gregory M., Dissanayaka, Nadeeka, Apostolova, Liana, Brown, Richard G., Dobkin, Roseanne, Dujardin, Kathy, Friedman, Joseph H., Leentjens, Albert F. G., Lenze, Eric J., Marsh, Laura, Mari, Lynda, Monchi, Oury, Richard, Irene H., Schrag, Anette, Strafella, Antonio P., Vernaleo, Beth, Weintraub, Daniel, and Mari, Zoltan

Published
2020
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38. A Prescription for Wellness in Early PD: Just What the Doctor Ordered.

Author

McDaniels, Bradley, Pontone, Gregory M., Keener, Adrienne M., and Subramanian, Indu

Subjects
*ADAPTABILITY (Personality), *PSYCHOLOGICAL factors, *PHYSICIANS, *PARKINSON'S disease, *LONELINESS, *WELL-being, *PARISH nursing
Abstract

Background: Being diagnosed with a neurodegenerative disease is a life-changing event and a critical time to help patients cope and move forward in a proactive way. Historically, the main focus of Parkinson's disease (PD) treatment has been on the motor features with limited attention given to non-motor and mental health sequelae, which have the most impact on quality of life. Although depression and anxiety have been described at the time of PD diagnosis, demoralization, intolerance of uncertainty, decreased self-efficacy, stigma and loneliness can also present and have negative effects on the trajectory of the disease. Hence, understanding the psychological impact of the diagnosis and how to provide better counselling at this critical time point may be the key to a better long-term trajectory and quality of life. Focus: There has been a paradigm shift in the treatment of chronic illness moving beyond the medical model, which focuses on fighting illness with the physician being in charge of the treatment process and the patient being the passive recipient, toward a more holistic (i.e., physical, psychological, social, and spiritual health) biopsychosocial approach that emphasizes behavioral factors with the patient being an active collaborator in their treatment. Hence, we propose that fostering resilience, social support, and psychological flexibility offer promise toward attenuating negative reactions and improving overall well-being. Conclusion: Through a proactive wellness approach incorporating lifestyle choices, people with PD (PwP) can not only achieve improved states of health, well-being, and quality of life, but actually thrive. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Phenomenology of Atypical Anxiety Disorders in Parkinson's Disease: A Systematic Review

Author

Dissanayaka, Nadeeka N, Forbes, Elana J, Perepezko, Kate, Leentjens, Albert F G, Dobkin, Roseanne D, Dujardin, Kathy, Pontone, Gregory M, Dissanayaka, Nadeeka N, Forbes, Elana J, Perepezko, Kate, Leentjens, Albert F G, Dobkin, Roseanne D, Dujardin, Kathy, and Pontone, Gregory M

Abstract

OBJECTIVE: Anxiety is a prominent concern in Parkinson's disease (PD) that negatively impacts quality of life, increases functional disability, and complicates clinical management. Atypical presentations of anxiety are under-recognized and inadequately treated in patients with PD, compromising global PD care.METHODS: This systematic review focuses on the prevalence, symptomology and clinical correlates of atypical presentations of PD-related anxiety following PRISMA guidelines.RESULTS: Of the 60 studies meeting inclusion criteria, 14 focused on 'Anxiety Not Otherwise Specified (NOS)' or equivalent, 31 reported on fluctuating anxiety symptoms, and 22 reported on 'Fear of Falling (FOF)'. Anxiety NOS accounted for a weighted mean prevalence of 14.9%, fluctuating anxiety for 34.19%, and FOF for 51.5%. These latter two exceeded the average reported overall prevalence rate of 31% for anxiety disorders in PD. We identified a diverse array of anxiety symptoms related to motor and non-motor symptoms of PD, to complications of PD medication (such as "on" and "off" fluctuations, or both), and, to a lesser extent, to cognitive symptoms.CONCLUSION: Atypical anxiety is common, clinically relevant, and heterogeneous in nature. A better understanding of the phenomenology, clinical course, and pathophysiology of varied forms of atypical anxiety in PD is needed to improve recognition, advance therapeutic development and ultimately optimize quality of life in PD.

Published
2022

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