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310 results on '"Ponti, Jessica"'

1. Particle size analysis of iron hydroxide adipate tartrate (IHAT) in a food supplement: Interlaboratory testing of a dynamic light scattering method

Author

Geiss, Otmar, Bianchi, Ivana, El Hadri, Hind, Ponti, Jessica, Brassinne, Frederic, Wouters, Charlotte, Mast, Jan, Loeschner, Katrin, Givelet, Lucas, Cubadda, Francesco, Raggi, Andrea, Ferraris, Francesca, Gräf, Volker, Mantovan, Etienne Devy, Zanella, Michela, Benetti, Federico, and Barrero-Moreno, Josefa

Published
2025
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5. Effects of spike protein and toxin-like peptides found in COVID-19 patients on human 3D neuronal/glial model undergoing differentiation: Possible implications for SARS-CoV-2 impact on brain development

Author

Pistollato, Francesca, Petrillo, Mauro, Clerbaux, Laure-Alix, Leoni, Gabriele, Ponti, Jessica, Bogni, Alessia, Brogna, Carlo, Cristoni, Simone, Sanges, Remo, Mendoza-de Gyves, Emilio, Fabbri, Marco, Querci, Maddalena, Soares, Helena, Munoz, Amalia, Whelan, Maurice, and Van de Eede, Guy

Published
2022
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12. A targeted next-generation gene panel reveals a novel heterozygous nonsense variant in the TP63 gene in patients with arrhythmogenic cardiomyopathy

Author

Poloni, Giulia, Calore, Martina, Rigato, Ilaria, Marras, Elena, Minervini, Giovanni, Mazzotti, Elisa, Lorenzon, Alessandra, Li Mura, Ilena Egle Astrid, Telatin, Andrea, Zara, Ivano, Simionati, Barbara, Perazzolo Marra, Martina, Ponti, Jessica, Occhi, Gianluca, Vitiello, Libero, Daliento, Luciano, Thiene, Gaetano, Basso, Cristina, Corrado, Domenico, Tosatto, Silvio, Bauce, Barbara, Rampazzo, Alessandra, and De Bortoli, Marzia

Published
2019
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20. Efficacy, biocompatibility and degradability of carbon nanoparticles for photothermal therapy of lung cancer

Author

Kokalari, Ida, Keshavan, Sandeep, Rahman, Mizanur, Gazzano, Elena, Barzan, Giulia, Mandrile, Luisa, Giovannozzi, Andrea, Ponti, Jessica, Antonello, Giulia, Monopoli, Marco, Perrone, Guido, Bergamaschi, Enrico, Riganti, Chiara, Fadeel, Bengt, and Fenoglio, Ivana

Subjects
Programmed cell death, Lung Neoplasms, photothermal therapy, Biocompatibility, DNA damage, biodegradation, carbon-based nanomaterials, immune cells, lung cancer, Biomedical Engineering, Medicine (miscellaneous), Bioengineering, 02 engineering and technology, Development, 03 medical and health sciences, Immune system, Cell Line, Tumor, Heat shock protein, medicine, Humans, General Materials Science, Lung cancer, 030304 developmental biology, 0303 health sciences, Chemistry, Photothermal therapy, 021001 nanoscience & nanotechnology, medicine.disease, Carbon, 3. Good health, A549 Cells, Cancer research, Nanoparticles, 0210 nano-technology, Phototoxicity
Abstract

Aim: To investigate near infrared-induced phototoxicity toward lung cancer cells, and the biodegradability and effect on immune cells of glucose-derived carbon nanoparticles (CNPs). Methods: The human A549 lung adenocarcinoma cell line was used as a model to study the phototoxicity of CNPs. The biodegradability and the effect on immune cells was demonstrated in primary human neutrophils and macrophages. Results: Near infrared-activated CNPs elicited rapid cell death, characterized by the elevation of heat shock proteins and the induction of DNA damage. CNPs were found to be noncytotoxic toward primary human macrophages and were susceptible to biodegradation when cocultured with human neutrophils. Conclusions: Our results identify CNPs as promising platforms for photothermal therapy of lung cancer.

Published
2021
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22. Reproducibility of methods required to identify and characterize nanoforms of substances

Author

Cross, Richard K., primary, Bossa, Nathan, additional, Stolpe, Björn, additional, Loosli, Frédéric, additional, Sahlgren, Nicklas Mønster, additional, Clausen, Per Axel, additional, Delpivo, Camilla, additional, Persson, Michael, additional, Valsesia, Andrea, additional, Ponti, Jessica, additional, Mehn, Dora, additional, Seleci, Didem Ag, additional, Müller, Philipp, additional, von der Kammer, Frank, additional, Rauscher, Hubert, additional, Spurgeon, Dave, additional, Svendsen, Claus, additional, and Wohlleben, Wendel, additional

Published
2022
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25. Reproducibility of methods required to identify and characterize nanoforms of substances

Author

Cross, Richard K., Bossa, Nathan, Stolpe, Björn, Loosli, Frédéric, Sahlgren, Nicklas Mønster, Clausen, Per Axel, Delpivo, Camilla, Persson, Michael, Valsesia, Andrea, Ponti, Jessica, Mehn, Dora, Seleci, Didem Ag, Müller, Philipp, von der Kammer, Frank, Rauscher, Hubert, Spurgeon, Dave, Svendsen, Claus, Wohlleben, Wendel, Cross, Richard K., Bossa, Nathan, Stolpe, Björn, Loosli, Frédéric, Sahlgren, Nicklas Mønster, Clausen, Per Axel, Delpivo, Camilla, Persson, Michael, Valsesia, Andrea, Ponti, Jessica, Mehn, Dora, Seleci, Didem Ag, Müller, Philipp, von der Kammer, Frank, Rauscher, Hubert, Spurgeon, Dave, Svendsen, Claus, and Wohlleben, Wendel

Abstract

•Nanoforms (NFs) of a substance may be distinguished from one another through differences in their physicochemical properties. When registering nanoforms of a substance for assessment under the EU REACH framework, five basic descriptors are required for their identification: composition, surface chemistry, size, specific surface area and shape. To make the risk assessment of similar NFs efficient, a number of grouping frameworks have been proposed, which often require assessment of similarity on individual physicochemical properties as part of the group justification. Similarity assessment requires an understanding of the achievable accuracy of the available methods. It must be demonstrated that measured differences between NFs are greater than the achievable accuracy of the method, to have confidence that the measured differences are indeed real. To estimate the achievable accuracy of a method, we assess the reproducibility of six analytical techniques routinely used to measure these five basic descriptors of nanoforms: inductively coupled plasma mass spectrometry (ICP-MS), Thermogravimetric analysis (TGA), Electrophoretic light scattering (ELS), Brunauer–Emmett–Teller (BET) specific surface area and transmission and scanning electron microscopy (TEM and SEM). Assessment was performed on representative test materials to evaluate the reproducibility of methods on single NFs of substances. The achievable accuracy was defined as the relative standard deviation of reproducibility (RSDR) for each method. •Well established methods such as ICP-MS quantification of metal impurities, BET measurements of specific surface area, TEM and SEM for size and shape and ELS for surface potential and isoelectric point, all performed well, with low RSDR, generally between 5 and 20%, with maximal fold differences usually <1.5 fold between laboratories. Applications of technologies such as TGA for measuring water content and putative organic impurities, additives or surface treatments (t

Published
2022

28. Evidence of SARS-CoV-2 bacteriophage potential in human gut microbiota

Author

Petrillo, Mauro, primary, Querci, Maddalena, additional, Brogna, Carlo, additional, Ponti, Jessica, additional, Cristoni, Simone, additional, Markov, Peter V, additional, Valsesia, Andrea, additional, Leoni, Gabriele, additional, Benedetti, Alessandro, additional, Wiss, Thierry, additional, and Van den Eede, Guy, additional

Published
2022
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29. sj-docx-1-jbf-10.1177_22808000221131881 – Supplemental material for Protein-corona formation on aluminum doped zinc oxide and gallium nitride nanoparticles

Author

Ciobanu, Vladimir, Roncari, Francesco, Ceccone, Giacomo, Braniste, Tudor, Ponti, Jessica, Bogni, Alessia, Guerrini, Giuditta, Cassano, Domenico, Colpo, Pascal, and Tiginyanu, Ion

Subjects
90399 Biomedical Engineering not elsewhere classified, FOS: Medical engineering
Abstract

Supplemental material, sj-docx-1-jbf-10.1177_22808000221131881 for Protein-corona formation on aluminum doped zinc oxide and gallium nitride nanoparticles by Vladimir Ciobanu, Francesco Roncari, Giacomo Ceccone, Tudor Braniste, Jessica Ponti, Alessia Bogni, Giuditta Guerrini, Domenico Cassano, Pascal Colpo and Ion Tiginyanu in Journal of Applied Biomaterials & Functional Materials

Published
2022
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33. Microplastics from miscellaneous plastic wastes: Physico-chemical characterization and impact on fish and amphibian development

Author

Bonfanti, Patrizia, primary, Colombo, Anita, additional, Saibene, Melissa, additional, Motta, Giulia, additional, Saliu, Francesco, additional, Catelani, Tiziano, additional, Mehn, Dora, additional, La Spina, Rita, additional, Ponti, Jessica, additional, Cella, Claudia, additional, Floris, Pamela, additional, and Mantecca, Paride, additional

Published
2021
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36. In Vivo Antitumor and Antimetastatic Efficacy of a Polyacetal‐Based Paclitaxel Conjugate for Prostate Cancer Therapy

Author

Fernández, Yolanda, primary, Movellan, Julie, additional, Foradada, Laia, additional, Giménez, Vanessa, additional, García‐Aranda, Natalia, additional, Mancilla, Sandra, additional, Armiñán, Ana, additional, Borgos, Sven Even, additional, Hyldbakk, Astrid, additional, Bogdanska, Anna, additional, Gobbo, Oliviero L., additional, Prina‐Mello, Adriele, additional, Ponti, Jessica, additional, Calzolai, Luigi, additional, Zagorodko, Oleksandr, additional, Gallon, Elena, additional, Niño‐Pariente, Amaya, additional, Paul, Alison, additional, Schwartz Jr, Simó, additional, Abasolo, Ibane, additional, and Vicent, María J., additional

Published
2021
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38. Biocompatibility study of two diblock copolymeric nanoparticles for biomedical applications by in vitro toxicity testing

Author

Goñi-de-Cerio, Felipe, Mariani, Valentina, Cohen, Dror, Madi, Lea, Thevenot, Julie, Oliveira, Hugo, Uboldi, Chiara, Giudetti, Guido, Coradeghini, Rosella, Garanger, Elisabeth, Rossi, François, Portugal-Cohen, Meital, Oron, Miriam, Korenstein, Rafi, Lecommandoux, Sébastien, Ponti, Jessica, Suárez-Merino, Blanca, and Heredia, Pedro

Published
2013
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40. Nanotoxicology

Author

Kinsner-Ovaskainen, Agnieszka, primary, Colpo, Pascal, additional, Ponti, Jessica, additional, and Rossi, François, additional

Published
2014
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41. Microplastics from miscellaneous plastic wastes: Physico-chemical characterization and impact on fish and amphibian development

Author

Bonfanti, P, Colombo, A, Saibene, M, Motta, G, Saliu, F, Catelani, T, Mehn, D, La Spina, R, Ponti, J, Cella, C, Floris, P, Mantecca, P, Bonfanti, Patrizia, Colombo, Anita, Saibene, Melissa, Motta, Giulia, Saliu, Francesco, Catelani, Tiziano, Mehn, Dora, La Spina, Rita, Ponti, Jessica, Cella, Claudia, Floris, Pamela, Mantecca, Paride, Bonfanti, P, Colombo, A, Saibene, M, Motta, G, Saliu, F, Catelani, T, Mehn, D, La Spina, R, Ponti, J, Cella, C, Floris, P, Mantecca, P, Bonfanti, Patrizia, Colombo, Anita, Saibene, Melissa, Motta, Giulia, Saliu, Francesco, Catelani, Tiziano, Mehn, Dora, La Spina, Rita, Ponti, Jessica, Cella, Claudia, Floris, Pamela, and Mantecca, Paride

Abstract

Microplastic pollution represents a global problem with negative impacts on aquatic environment and organisms' health. To date, most of the laboratory toxicological studies on microplastics (MPs) have made use of single commercial micro and nano-polymers, which do not reflect the heterogeneity of environmental MPs. To improve the relevance of the hazard assessment, micrometer-sized plastic particles of miscellaneous non-reusable waste plastics, with size <100 mu m and <50 mu m (waste microplastics, wMPs), were characterized by microscopic and spectroscopic techniques and tested on developing zebrafish and Xenopus laevis by FET and FETAX assays respectively. Moreover, the modalities of wMP interaction with the embryonic structures, as well as the histological lesions, were explored by light and electron microscopy. We have shown that wMPs had very heterogeneous shapes and sizes, were mainly composed of polyethylene and polypropylene and contained metal and organic impurities, as well as submicrometric particle fractions, features that resemble those of environmental occurring MPs. wMPs (0.1-100 mg/L) caused low rate of mortality and altered phenotypes in embryos, but established species-specific biointeractions. In zebrafish, wMPs by adhering to chorion were able to delay hatching in a size and concentration dependent manner. In Xenopus embryos, which open stomodeum earlier than zebrafish, wMPs were accumulated in intestinal tract, where produced mechanical stress and stimulated mucus overproduction, attesting an irritation response. Although wMP biointeractions did not interfere with morphogenesis processes, further studies are needed to understand the underlying mechanisms and long-term impact of these, or even smaller, wMPs.

Published
2021

44. Towards predictive nanotoxicology: from roundabout of molecular events to chronic inflammation prediction

Author

Majaron, Hana, Kokot, Boštjan, Sebastijanović, Aleksandar, Voss, Carola, Podlipec, Rok, Zawilska, Patrycja, Berthing, Trine, Ballester, Carolina, Danielsen, Pernille Høgh, Contini, Claudia, Ivanov, Mikhail, Krišelj, Ana, Čotar, Petra, Zhou, Qiaoxia, Ponti, Jessica, Zhernovkov, Vadim, Schneemilch, Matthew, Pušnik, Mojca, Umek, Polona, Pajk, Stane, Joubert, Olivier, Schmid, Otmar, Urbančič, Iztok, Irmler, Martin, Beckers, Johannes, Lobaskin, Vladimir, Halappanavar, Sabina, Quirke, Nicholas, Lyubartsev, Alexander, Vogel, Ulla, Koklič, Tilen, Stöger, Tobias, and Štrancar, Janez

Abstract

Many chronic diseases manifest themselves in prolonged inflammation and often ignored dysregulated lipid metabolism, both also associated with inhalation of certain nanomaterials. Limited knowledge of involved molecular events and their causal connections prevents reliable prediction of outcomes by efficient testing strategies. To unravel how acute nanomaterial exposure leads to chronic conditions, we employed advanced microscopy and omics in vitro , in vivo and in silico . For selected metal-oxide nanomaterials, we show that epithelial cells survive the exposure by excreting internalized nanomaterials and passivating them on the surface, employing elevated lipid synthesis. Macrophages, on the contrary, attack the defending epithelium but die degrading passivized complexes, releasing nanomaterial, which is reuptaken by epithelial cells. Constant proinflammatory signalling recruits new phagocytes that feed the vicious cycle of events resulting in a long-lasting response to a single exposure. The discovered mechanism predicts the nanomaterial-associated in vivo chronic outcomes based on simple in vitro measurements and potentially enlightens other chronic diseases. Graphical abstract

Published
2020
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45. Prediction of Chronic Inflammation for Inhaled Particles: the Impact of Material Cycling and Quarantining in the Lung Epithelium

Author

Joubert, Olivier, Kokot, Hana, Kokot, Boštjan, Sebastijanović, Aleksandar, Voss, Carola, Podlipec, Rok, Zawilska, Patrycja, Berthing, Trine, Ballester-López, Carolina, Danielsen, Pernille Høgh, Contini, Claudia, Ivanov, Mikhail, Krišelj, Ana, Čotar, Petra, Zhou, Qiaoxia, Ponti, Jessica, Zhernovkov, Vadim, Schneemilch, Matthew, Doumandji, Zahra, Pušnik, Mojca, Umek, Polona, Pajk, Stane, Schmid, Otmar, Urbančič, Iztok, Irmler, Martin, Beckers, Johannes, Lobaskin, Vladimir, Halappanavar, Sabina, Quirke, Nick, Lyubartsev, Alexander, Vogel, Ulla, Koklič, Tilen, Stoeger, Tobias, Štrancar, Janez, Ballester‐López, Carolina, Institut Jean Lamour (IJL), Université de Lorraine (UL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Commission of the European Communities

Subjects
MESH: Inflammation, Technology, material safety and health hazards, Chemistry, Multidisciplinary, [SDV]Life Sciences [q-bio], 02 engineering and technology, Advanced materials, 01 natural sciences, 09 Engineering, Epithelium, NANOPARTICLES, General Materials Science, Lung, 02 Physical Sciences, Single exposure, Chemistry, Physical, Physics, HAZARD, advanced microscopies, 021001 nanoscience & nanotechnology, Material development, adverse outcome pathways, 3. Good health, ddc, Chemistry, Physics, Condensed Matter, CHEMICAL SAFETY, Inhalation, MESH: Particulate Matter, Advanced Microscopies, Adverse Outcome Pathways, Disease Prediction, Material Safety And Health Hazards, Mode Of Action, Mechanics of Materials, Lung epithelium, Physical Sciences, Science & Technology - Other Topics, MESH: Inhalation, Safety, medicine.symptom, 03 Chemical Sciences, 0210 nano-technology, NANOTOXICOLOGY, disease prediction, Materials science, In silico, Materials Science, Materials Science, Multidisciplinary, Inflammation, Computational biology, Predictive toxicology, 010402 general chemistry, Physics, Applied, ACTIN, mode of action, MESH: Computer Simulation, Toxicity Tests, medicine, Computer Simulation, MESH: Lung, EXPOSURE, MESH: Particle Size, Nanoscience & Nanotechnology, Particle Size, MESH: Toxicity Tests, NANOMATERIALS, Science & Technology, Mechanical Engineering, MESH: Chronic Disease, MESH: Safety, 0104 chemical sciences, MESH: Epithelium, MOLECULAR-DYNAMICS, Chronic Disease, Particulate Matter, MATTER, RESPONSES
Abstract

International audience; On a daily basis, people are exposed to a multitude of health-hazardous airborne particulate matter with notable deposition in the fragile alveolar region of the lungs. Hence, there is a great need for identification and prediction of material-associated diseases, currently hindered due to the lack of in-depth understanding of causal relationships, in particular between acute exposures and chronic symptoms. By applying advanced microscopies and omics to in vitro and in vivo systems, together with in silico molecular modeling, it is determined herein that the long-lasting response to a single exposure can originate from the interplay between the newly discovered nanomaterial quarantining and nanomaterial cycling between different lung cell types. This new insight finally allows prediction of the spectrum of lung inflammation associated with materials of interest using only in vitro measurements and in silico modeling, potentially relating outcomes to material properties for a large number of materials, and thus boosting safe-by-design-based material development. Because of its profound implications for animal-free predictive toxicology, this work paves the way to a more efficient and hazard-free introduction of numerous new advanced materials into our lives.

Published
2020
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47. Prediction of Chronic Inflammation for Inhaled Particles : the Impact of Material Cycling and Quarantining in the Lung Epithelium

Author

Kokot, Hana, Kokot, Boštjan, Sebastijanović, Aleksandar, Voss, Carola, Podlipec, Rok, Zawilska, Patrycja, Berthing, Trine, Ballester‐López, Carolina, Høgh Danielsen, Pernille, Contini, Claudia, Ivanov, Mikhail, Krišelj, Ana, Čotar, Petra, Zhou, Qiaoxia, Ponti, Jessica, Zhernovkov, Vadim, Schneemilch, Matthew, Doumandji, Zahra, Pušnik, Mojca, Umek, Polona, Pajk, Stane, Joubert, Olivier, Schmid, Otmar, Urbančič, Iztok, Irmler, Martin, Beckers, Johannes, Lobaskin, Vladimir, Halappanavar, Sabina, Quirke, Nick, Lyubartsev, Alexander P., Vogel, Ulla, Koklič, Tilen, Stoeger, Tobias, Štrancar, Janez, Kokot, Hana, Kokot, Boštjan, Sebastijanović, Aleksandar, Voss, Carola, Podlipec, Rok, Zawilska, Patrycja, Berthing, Trine, Ballester‐López, Carolina, Høgh Danielsen, Pernille, Contini, Claudia, Ivanov, Mikhail, Krišelj, Ana, Čotar, Petra, Zhou, Qiaoxia, Ponti, Jessica, Zhernovkov, Vadim, Schneemilch, Matthew, Doumandji, Zahra, Pušnik, Mojca, Umek, Polona, Pajk, Stane, Joubert, Olivier, Schmid, Otmar, Urbančič, Iztok, Irmler, Martin, Beckers, Johannes, Lobaskin, Vladimir, Halappanavar, Sabina, Quirke, Nick, Lyubartsev, Alexander P., Vogel, Ulla, Koklič, Tilen, Stoeger, Tobias, and Štrancar, Janez

Abstract

On a daily basis, people are exposed to a multitude of health-hazardous airborne particulate matter with notable deposition in the fragile alveolar region of the lungs. Hence, there is a great need for identification and prediction of material-associated diseases, currently hindered due to the lack of in-depth understanding of causal relationships, in particular between acute exposures and chronic symptoms. By applying advanced microscopies and omics to in vitro and in vivo systems, together with in silico molecular modeling, it is determined herein that the long-lasting response to a single exposure can originate from the interplay between the newly discovered nanomaterial quarantining and nanomaterial cycling between different lung cell types. This new insight finally allows prediction of the spectrum of lung inflammation associated with materials of interest using only in vitro measurements and in silico modeling, potentially relating outcomes to material properties for a large number of materials, and thus boosting safe-by-design-based material development. Because of its profound implications for animal-free predictive toxicology, this work paves the way to a more efficient and hazard-free introduction of numerous new advanced materials into our lives.

Published
2020
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