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24. Scandinavian Society for the Study of Diabetes abstracts: Second meeting Helsinki, Finland, October 28–30, 1965

Author

Östman, Jan, Gustaf, Konung, Bremer, Jon, Svanborg, Alvar, Munkner, Carsten, Nikkilä, Esko, Heding, L., Jonsson, A., Ørskov, H., Hansen, R. Østerby, Lundbæk, K., Olsen, Steen, Christensen, N. Juel, Ørskov, Hans, Lundbæk, Knud, Deckert, T., Lyngsoe, J., Rafaelsen, O. J., Deckert, Torsten, Thorell, J., Bjørntorp, P., Pelkonen, R., Kekki, M., Nikktlä, E. A., Miettinen, T. A., Pelkoneen, R., Vesenne, M., Nikkilä, E. A., Miettinen, A., Carlström, Sven, Persson, B., Sterkey, G., Jakobson, T., Kahanpää, A., Berglund, B., Kiekkala, Kilkka, Ahola, T., Åkerblom, H., Oksala, Arvo, Kallio, Veikko, Varonen, Eeva-Raija, Iversen, Mogens, Englund, Flemming, Wollesen, Flemming, Hansen, Egon, Andresen, Paul, Burstein, J., Lindell, K., Nikiforow, R., Fagerberg, Sven-Erik, Hellerström, C., Jönsson, Lars-Erik, Pontén, Jan, Thorell, Jan, Lamberg, B. A., Nielsen, M. D., Binder, Chr, Munck, O., Jorgensen, K., Nielsen, Aa. Vølund, Relander, A., Räihä, C. -E., Skovborg, F., and Ditzel, J.

Published
1966
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27. List of Contributors

Author

Anders, J.J., primary, Arnold, Ellen Bragg, additional, Bignami, Amico, additional, Bisby, M.A., additional, Brightman, M.W., additional, Dahl, Doris, additional, Hamprecht, Bernd, additional, Henn, Fritz A., additional, Kato, Takahiko, additional, McGeer, E.G., additional, McGeer, P.L., additional, Manthorpe, Marston, additional, Messer, Anne, additional, Pontén, Jan, additional, Rosenstein, J.M., additional, Rueger, David C., additional, Szuchet, Sara, additional, Stefansson, Kari, additional, van Calker, Dietrich, additional, Varon, Silvio, additional, Vernadakis, Antonia, additional, and Westermark, Bengt, additional

Published
1980
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30. List of Contributors

Author

ABAZA, NABIL, primary, ABSHER, MARLENE, additional, AFTONOMOS, BYRON TH., additional, ANDERSEN, CORINE R., additional, ARRIGHI, FRANCES E., additional, AVRAMEAS, S., additional, BAKER, RALPH, additional, BARILE, MICHAEL F., additional, BARSKI, G., additional, BEASLEY, ANNIE R., additional, BELEHRADEK, J., additional, BOONE, CHARLES W., additional, BORNSTEIN, J., additional, BORNSTEIN, MURRAY B., additional, BRAUTBAR, CHAIM, additional, BRIDSON, W.E., additional, BRINKLEY, B.R., additional, CASTOR, LAROY N., additional, CHANG, JEFFREY P., additional, CHARNEY, JESSE, additional, CHERRY, WILLIAM R., additional, CLARK, H FRED, additional, CLIVER, D.O., additional, CONWAY, E., additional, COOPER, JOHN E.K., additional, CORIELL, LEWIS L., additional, Cox, RODY P., additional, CRISTOFALO, V.J., additional, CUNNINGHAM, C.H., additional, DALEN, H., additional, DALY, W.F., additional, DANCIS, JOSEPH, additional, DANES, B. SHANNON, additional, DANNIES, P.S., additional, DEITCH, A.D., additional, DELL'ORCO, R.T., additional, DOUGALL, D.K., additional, EDELMAN, GERALD M., additional, EISINGER, MAGDALENA, additional, EISLER, WILLIAM J., additional, EVANS, VIRGINIA J., additional, FALK, L., additional, FARBER, ROSANN A., additional, FEDOROFF, S., additional, FIRKET, H., additional, FOLEY, JOHN F., additional, FREED, JEROME J., additional, GALLAGHER, JAMES G., additional, GAMBORG, O.L., additional, GARTLER, STANLEY M., additional, GAUTVIK, K.M., additional, GENGOZIAN, NAZARETH, additional, GILES, RICHARD E., additional, GODMAN, G.C., additional, GOLDBERG, B., additional, GREENE, ARTHUR E., additional, GULLINO, P.M., additional, GWATKIN, RALPH B.L., additional, HACKETT, A.J., additional, HAM, RICHARD G., additional, HARRIS, M., additional, HAYFLICK, LEONARD, additional, HEIDELBERGER, CHARLES, additional, HELLER, RENÉ, additional, HILDEBRANDT, A.C., additional, HILFER, S. ROBERT, additional, HOLDEN, H.T., additional, HOUSE, WILLIAM, additional, Hsu, T.C., additional, HULL, ROBERT N., additional, HUTZLER, JOEL, additional, KABAKJIAN, JOAN, additional, KAHN, R.H., additional, KAIGHN, M. EDWARD, additional, KALTER, S.S., additional, KAO, K.N., additional, KASTEN, FREDERICK H., additional, KEEN, L.N., additional, KINNAMAN, HAROLD, additional, KNAZEK, R.A., additional, KOHLER, P.O., additional, KOLODNY, G.M., additional, KRAHN, DAVID F., additional, KRAMARSKY, B., additional, KROOTH, ROBERT S., additional, KRUSE, P.F., additional, KURZ, W.G.W., additional, LARSON, B.L., additional, LASFARGUES, E.Y., additional, LEE, JOHN C., additional, LEIGHTON, JOSEPH, additional, LICHTER, W., additional, LIN, C.C., additional, LITWIN, JACK, additional, MCKENZIE, LAURA S., additional, MCKINNEY, E. CHURCHILL, additional, MACPHERSON, IAN, additional, MACIEIRA-COELHO, A., additional, MACY, MARVIN L., additional, MANSUKHANI, SUNDER, additional, MARKS, E.P., additional, MARTIN, G.M., additional, MATHES, M.C., additional, MATSUOKA, YUJI, additional, MAXWELL, M.D., additional, MELLMAN, W.J., additional, MELNICK, P.J., additional, MERTENS, J.G., additional, MEZGER-FREED, LISELOTTE, additional, MILLER, R.A., additional, MIRANDA, A.F., additional, MOEHRING, J.M., additional, MOFFAT, MARGARET A.J., additional, DE OCA, HÉCTOR MONTES, additional, MOORHEAD, PAUL S., additional, MORGAN, JOSEPH F., additional, MORTON, HELEN J., additional, MURASHIGE, T., additional, PARTANEN, CARL R., additional, PATTERSON, M.K., additional, PATTILLO, ROLAND A., additional, PERAINO, CARL, additional, PHILLIPS, HUGH J., additional, PONTÉN, JAN, additional, PORTER, RAYMOND P., additional, PROP, F.J.A., additional, PUMPER, R.W., additional, QUADRACCI, LEONARD J., additional, RABINOWITZ, Y., additional, RAPP, F., additional, REYNOLDS, R., additional, REZNIKOFF, CATHRINE A., additional, RICHTER, ALAN, additional, ROBB, JAMES A., additional, ROBBINS, E., additional, ROSE, GEORGE G., additional, ROSENTHAL, LEONARD J., additional, ROUNDS, D.E., additional, RUBIN, H., additional, RUDDLE, FRANK H., additional, SANFORD, K.K., additional, SAVAGEAU, M.A., additional, SCHLEICHER, JOSEPH B., additional, SCHNEIDER, IMOGENE, additional, SCHWARTZ, BERNARD, additional, SCHWARTZ, P.L., additional, SELL, ELIZABETH K., additional, SHALL, SYDNEY, additional, SHANNON, JOHN E., additional, SHECHMEISTER, ISAAC L., additional, SHIPMAN, CHARLES, additional, SHRAMEK, G., additional, SIGEL, M. MICHAEL, additional, SIMPSON, W.F., additional, SMITH, ROBERT F., additional, STEEVES, T.A., additional, STEPHENSON, N.G., additional, STINEBRING, W.R., additional, STREET, H.E., additional, STRIKER, GARY E., additional, STULBERG, C.S., additional, SYKES, J.A., additional, TASHJIAN, A.H., additional, TAYLOR, WILLIAM G., additional, TEDESCO, T.A., additional, THAYER, PHILIP S., additional, TORREY, JOHN G., additional, UCHIDA, IRENE A., additional, VALENTI, CARLO, additional, VAN'T HOF, J., additional, VAN WEZEL, A.L., additional, VASIL, I.K., additional, VAUGHN, JAMES L., additional, WANG, H.C., additional, WAYMOUTH, CHARITY, additional, WEAVER, GEORGE, additional, WETTENHALL, R.E.H., additional, WHITTLE, W.L., additional, WIEPJES, G.J., additional, WINTON, L.L., additional, WOLF, KEN, additional, and YAFFE, DAVID, additional

Published
1973
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40. A prospective study showing long-term infection with human papillomavirus 16 before the development of cervical carcinoma in situ

Author

Ylitalo, Nathalie, Josefsson, Agnetha, Melbye, Mads, Sörensen, Per, Frisch, Morten, Andersen, Per Kragh, Sparén, Pär, Gustafsson, Margit, Magnusson, Patrik, Pontén, Jan, Gyllensten, Ulf, Adami, Hans-Olov, Ylitalo, Nathalie, Josefsson, Agnetha, Melbye, Mads, Sörensen, Per, Frisch, Morten, Andersen, Per Kragh, Sparén, Pär, Gustafsson, Margit, Magnusson, Patrik, Pontén, Jan, Gyllensten, Ulf, and Adami, Hans-Olov

Abstract

Human papillomavirus 16 (HPV16) is a predominant cause of cervical neoplasia. However, no population-based study with long-term follow-up has clarified the temporal relationship between HPV16 infection and occurrence of carcinoma in situ, or the importance of recurrent or persistent infection. This nested case-control study was carried out in a population-based cohort of women participating in cytological screening whose initial smear, taken in 1969-1995, was normal. During up to 26 years of follow-up, carcinoma in situ was diagnosed in 484 eligible women. Archival smears from these women were compared with smears from 619 individually matched controls. After DNA extraction, a highly sensitive PCR system was used to detect HPV16. Among case women, the prevalence of HPV16 positivity was 56% at the time of diagnosis. The relative risk of cervical carcinoma in situ increased from 3.6 (95% confidence interval, 1.2-11.0) 13 years before diagnosis to 11.1 (95% confidence interval, 5.5-22.2) 1 year before diagnosis. Having a positive smear at entry to the cohort increased risk >5-fold, whereas having persistent infection with HPV in two subsequent smears increased risk 30-fold. We estimated that among HPV16-positive women, the median incubation period from infection to carcinoma in situ was 7-12 years. We conclude that evidence of persistent and/or recurrent infection is associated with a drastically higher risk of cervical carcinoma in situ than occasional infection with HPV16.

Published
2000

42. A Prospective Study Showing Long-Term Infection with Human Papillomavirus 16 before the Development of Cervical Carcinoma in situ 1: a nested case-control study

Author

Ylitalo, Nathalie, Josefsson, Agnetha M., Melbye, Mads, Sørensen, Per, Frisch, Morten, Andersen, Per Kragh, Sparén, Pär, Gustafsson, Margit, Magnusson, Patrik K.E., Pontén, Jan, Gyllensten, Ulf B., Adami, Hans-Olav, Ylitalo, Nathalie, Josefsson, Agnetha M., Melbye, Mads, Sørensen, Per, Frisch, Morten, Andersen, Per Kragh, Sparén, Pär, Gustafsson, Margit, Magnusson, Patrik K.E., Pontén, Jan, Gyllensten, Ulf B., and Adami, Hans-Olav

Published
2000

43. Smoking and oral contraceptives as risk factors for cervical carcinoma in situ

Author

Ylitalo, Nathalie, Sörensen, Per, Josefsson, Agnetha, Frisch, Morten, Sparén, Pär, Pontén, Jan, Gyllensten, Ulf, Melbye, Mads, Adami, Hans-Olov, Ylitalo, Nathalie, Sörensen, Per, Josefsson, Agnetha, Frisch, Morten, Sparén, Pär, Pontén, Jan, Gyllensten, Ulf, Melbye, Mads, and Adami, Hans-Olov

Abstract

Human papillomavirus (HPV) is probably a necessary but definitely not a sufficient cause of cervical carcinoma. However, it remains unclear which factors, in addition to HPV, are important for the development of cervical carcinoma and its precursor lesions. To address this issue, we conducted a case-control study nested in a population-based cohort consisting of women participating in cytological screening in one Swedish county, any time during 1969 through 1995. Detailed information on sexual practice, smoking habits and oral contraceptive (OC) use were collected through telephone interviews with 422 case patients diagnosed with cervical carcinoma in situ and 422 control subjects. All cytological smears were analyzed for presence of HPV 16/18 by a polymerase chain reaction (PCR)-based method. Odds ratios (OR) were used as measures of relative risk. After multivariate adjustment, a 2-fold higher risk was observed among current smokers compared with never smokers [OR 1.94; 95% confidence interval (CI 1.32-2.85)], an association apparently confined to women younger than 45 years. Current use of OCs was associated with a 4-fold increased risk overall (OR 3.64; 95% CI 1.91-6.93) with a monotonic increase with increasing duration of use (p for trend < 0.001). The number of sexual partners was significantly, positively associated with risk among HPV 16/18-negative (p for trend < 0.005) but not among HPV 16/18-positive women. Our data confirm the association between smoking and cervical carcinoma in situ, which might be age-dependent. Our results further indicate a relation with OC use and the risk for cervical carcinoma in situ.

Published
1999

44. p53 polymorphism and risk of cervical cancer

Author

Josefsson, Agnetha M., Magnusson, Partik K. E., Ylitalo, Nathalie, Quarforth-Tubbin, Pernilla, Pontén, Jan, Adami, Hans-Olov, Gyllensten, Ulf B., Josefsson, Agnetha M., Magnusson, Partik K. E., Ylitalo, Nathalie, Quarforth-Tubbin, Pernilla, Pontén, Jan, Adami, Hans-Olov, and Gyllensten, Ulf B.

Published
1998
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47. International incidence rates of invasive cervical cancer before cytological screening

Author

Gustafsson, Leif, Pontén, Jan, Bergström, Reinhold, Adami, Hans-Olov, Gustafsson, Leif, Pontén, Jan, Bergström, Reinhold, and Adami, Hans-Olov

Abstract

Huge differences in incidence rates of invasive cervical cancer occur among populations. These differences reflect the influences of both etiological environmental factors and removal of precursor lesions detected upon screening. The purposes of this article are (i) to describe similarities and differences in the shapes and magnitudes of age-specific incidence rates of invasive cervical cancer before screening had an effect, (ii) to provide baseline data for further global study of screening effects, and (iii) to provide baseline incidence data for the design of optimal screening programs. To eliminate the impact of screening effects, we have selected age-specific incidence rates from times when and from populations in which screening was insignificant. The selected rates were suitably scaled and compared regarding age at onset of increase in incidence, age at peak incidence, and rate of subsequent decline. Despite a 16-fold difference in incidence rates, all curves had the same basic structure, with an increase to a peak followed by a decline or a plateau. Although all populations but one had an onset around age 25, 7 European countries showed an earlier peak age (mean = 46 vs. 59) and a more rapid decline after the peak than most other populations. The common basic shape of the age-specific incidence curve, overall, suggests a relatively similar development of invasive cervical cancer in different populations. These results illustrate the underlying similarities in the markedly different age-specific incidence rates of invasive cervical cancer. They also provide a basis for studying screening effects and for optimizing screening programs in specific geographic areas.

Published
1997
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