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831 results on '"Ponsioen, Cyriel Y."'

1. Loss of biochemical response at any time worsens outcomes in UDCA-treated patients with primary biliary cholangitis

Author

Roberts, Surain B., Choi, Woo Jin, Worobetz, Lawrence, Vincent, Catherine, Flemming, Jennifer A., Cheung, Angela, Qumosani, Karim, Swain, Mark, Grbic, Dusanka, Ko, Hin Hin, Peltekian, Kevork M., Abrahamyan, Lusine, Saini, Monika, Tirona, Kattleya, Aziz, Bishoi, Lytvyak, Ellina, Invernizzi, Pietro, Ponsioen, Cyriel Y., Bruns, Tony, Cazzagon, Nora, Lindor, Keith, Dalekos, George N., Gatselis, Nikolaos K., Verhelst, Xavier, Floreani, Annarosa, Corpechot, Christophe, Mayo, Marlyn J., Levy, Cynthia, Londoño, Maria-Carlota, Battezzati, Pier M., Pares, Albert, Nevens, Frederik, van der Meer, Adriaan, Kowdley, Kris V., Trivedi, Palak J., Lleo, Ana, Thorburn, Douglas, Carbone, Marco, Selzner, Nazia, Gulamhusein, Aliya F., Janssen, Harry LA., Montano-Loza, Aldo J., Mason, Andrew L., Hirschfield, Gideon M., and Hansen, Bettina E.

Published
2024
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2. Incidence and prevalence of primary biliary cholangitis in the Netherlands – A nationwide cohort study

Author

Abraham, Sunje, Adang, Rob P.R., Aktas, Huseyin, Alderlieste, Yasser A., Aparicio-Pages, Maria N., Baak, L. (Bert) C., Baven-Pronk, Martine A.M.C., van der Beek, A. (Sander), Bekkering, Frank C., van Bergeijk, Jeroen D., Beuers, Ulrich, Beukema, Menno, de Boer, Wink, Boersma, Femke, Boonstra, Kirsten, ter Borg, Frank, ter Borg, Martijn J., ter Borg, Pieter C.J., de Bruin, Gijs J., Bus, Paul J., Cahen, Djuna L., Cazemier, Marcel, Cuperus, Frans J.C., van Dam, Lisette J.H., Denters, Maaike J., Drenth, Joost P.H., Epping, Ludger S.M., Erler, Nicole S., Flink, Hajo J., Friederich, Philip W., van Gerven, Nicole F.M., Gevers, Tom J.G., Hansen, Bettina E., van den Hazel, Sven J., van Hoek, Bart, van Hooff, Maria C., Hotho, Daphne M., Janssen, Harry L.A., de Jonge, Hendrik J.M., Jurgens, Matthias C., Kemenade, J.(Netty) van, Kerbert-Dreteler, Marjo J., Klemt-Kropp, Michael, Konings, Ingrid C.A.W., de Kort, Sander, Kuiper, Edith M.M., Kuyvenhoven, Johan P.H., van der Meer, Adriaan J., van Meer, Suzanne, Onderwater, Susanne L., Oterdoom, Leendert H., Ponsioen, Cyriel Y., van Putten, Paul G., van Rooij, Janne E., Roomer, Robert, Schmidt-Böhmer, Johannes, Schmittgens, Stephan, Schreuder, Tim C.M.A., Nicolaas, Jerome Sint, van Soest, Hanneke, Soufidi, Khalida, van Stiphout, Stephan H.C., Thio, Hans H.K., Tielemans, Merel M., Vandebosch, Sigrid, de Veer, Rozanne C., Veldt, Bart J., Verdonk, Robert C., Marleen de Vree, J., de Vries, Elsemieke, Vrieze, Anne, Vrolijk, Jan Maarten, van der Waaij, Laurens A., Werner, Ellen, de Wit, Ulrike, Wolfhagen, Frank H.J., van Hooff, Maria C.B., Baak, L.C., and Borg, Frank ter

Published
2024
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3. Dynamic Prediction of Advanced Colorectal Neoplasia in Inflammatory Bowel Disease

Author

van Bodegraven, Adriaan A., Fidder, Herma H., Hirdes, Meike M.C., Hoentjen, Frank, Jansen, Jeroen M., Mahmmod, Nofel, van der Meulen-de Jong, Andrea E., Ponsioen, Cyriel Y., van Schaik, Fiona D.M., van der Woude, C. Janneke, Wijnands, Anouk M., Penning de Vries, Bas B.L., Lutgens, Maurice W.M.D., Bakhshi, Zeinab, Al Bakir, Ibrahim, Beaugerie, Laurent, Bernstein, Charles N., Chang-ho Choi, Ryan, Coelho-Prabhu, Nayantara, Graham, Trevor A., Hart, Ailsa L., ten Hove, Joren R., Itzkowitz, Steven H., Kirchgesner, Julien, Mooiweer, Erik, Shaffer, Seth R., Shah, Shailja C., Elias, Sjoerd G., and Oldenburg, Bas

Published
2024
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5. Recurrent cholangitis in patients with a non-stenotic hepaticojejunostomy: incidence and risk factors

Author

Overdevest, Anouk G., Fritzsche, Jeska A., Smit, Mark A.D., Besselink, Marc G., Bonomi, Alessandro M., Busch, Olivier R., Daams, Freek, van Delden, Otto M., Kazemier, Geert, Langver, Jesse, Ponsioen, Cyriel Y., Swijnenburg, Rutger-Jan, van Wanrooij, Roy L.J., Wielenga, Mattheus C.B., Zonderhuis, Babs M., Zijlstra, IJsbrand A.J., Erdmann, Joris I., and Voermans, Rogier P.

Published
2024
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8. HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis

Author

Akar, Alaa, Flemming, Cornelius, Felix, Flomm, Flosbach, Markus, Jäger, Julia, Jeromin, Niklas, Jung, Johannes, Ohms, Mareike, Reinshagen, Konrad, Rische, Johann, Sagebiel, Adrian, Sandfort, Deborah, Steinert, Fenja, Tomuschat, Christian, Wesche, Jasmin, Shifteh Abedian, Abraham, Clara, Achkar, Jean-Paul, Ahmad, Tariq, Alberts, Rudi, Alizadeh, Behrooz, Amininejad, Leila, Ananthakrishnan, Ashwin N., Andersen, Vibeke, Anderson, Carl A., Andrews, Jane M., Annese, Vito, Aumais, Guy, Baidoo, Leonard, Baldassano, Robert N., Bampton, Peter A., Barclay, Murray, Barrett, Jeffrey C., Bethge, Johannes, Bewshea, Claire, Bis, Joshua C., Bitton, Alain, BK, Thelma, Boucher, Gabrielle, Brain, Oliver, Brand, Stephan, Brant, Steven R., Cheon, Jae Hee, Chew, Angela, Cho, Judy H., Cleynen, Isabelle, Cohain, Ariella, Cooney, Rachel, Croft, Anthony, Daly, Mark J., D'Amato, Mauro, Danese, Silvio, Daryani, Naser Ebrahim, Datta, Lisa Wu, Degenhardt, Frauke, Denapiene, Goda, Denson, Lee A., Devaney, Kathy L., Dewit, Olivier, D'Inca, Renata, Drummond, Hazel E., Dubinsky, Marla, Duerr, Richard H., Edwards, Cathryn, Ellinghaus, David, Ellul, Pierre, Esaki, Motohiro, Essers, Jonah, Ferguson, Lynnette R., Festen, Eleonora A., Fleshner, Philip, Florin, Tim, Franchimont, Denis, Franke, Andre, Fuyuno, Yuta, Gearry, Richard, Georges, Michel, Gieger, Christian, Glas, Jürgen, Goyette, Philippe, Green, Todd, Griffiths, Anne M., Guthery, Stephen L., Hakonarson, Hakon, Halfvarson, Jonas, Hanigan, Katherine, Haritunians, Talin, Hart, Ailsa, Hawkey, Chris, Hayward, Nicholas K., Hedl, Matija, Henderson, Paul, Hold, Georgina L., Hong, Myhunghee, Hu, Xinli, Huang, Hailiang, Hugot, Jean-Pierre, Hui, Ken Y., Imielinski, Marcin, Jazayeri, Omid, Jonaitis, Laimas, Jostins, Luke, Juyal, Garima, Chandra Juyal, Ramesh, Kalla, Rahul, Karlsen, Tom H., Kennedy, Nicholas A., Khan, Mohammed Azam, Kim, Won Ho, Kitazono, Takanari, Kiudelis, Gediminas, Kubo, Michiaki, Kugathasan, Subra, Kupcinskas, Limas, Lamb, Christopher A., de Lange, Katrina M., Latiano, Anna, Laukens, Debby, Lawrance, Ian C., Lee, James C., Lees, Charlie W., Leja, Marcis, Lewis, Nina, Van Limbergen, Johan, Lionetti, Paolo, Liu, Jimmy Z., Louis, Edouard, Luo, Yang, Mahy, Gillian, Malekzadeh, Masoud Mohammad, Malekzadeh, Reza, Mansfield, John, Marriott, Suzie, Massey, Dunecan, Mathew, Christopher G., Matsui, Toshiyuki, McGovern, Dermot P.B., van der Meulen, Andrea, Midha, Vandana, Milgrom, Raquel, Mirzaei, Samaneh, Mitrovic, Mitja, Montgomery, Grant W., Mowat, Craig, Müller, Christoph, Newman, William G., Ng, Aylwin, Ng, Siew C., Evelyn Ng, Sok Meng, Nikolaus, Susanna, Ning, Kaida, Nöthen, Markus, Oikonomou, Ioannis, Okou, David, Orchard, Timothy R., Palmieri, Orazio, Parkes, Miles, Phillips, Anne, Ponsioen, Cyriel Y., Potocnik, Urõs, Poustchi, Hossein, Prescott, Natalie J., Proctor, Deborah D., Radford-Smith, Graham, Rahier, Jean- Francois, Regueiro, Miguel, Reinisch, Walter, Rieder, Florian, Rioux, John D., Roberts, Rebecca, Rogler, Gerhard, Russell, Richard K., Sanderson, Jeremy D., Sans, Miquel, Satsangi, Jack, Schadt, Eric E., Scharl, Michael, Schembri, John, Schreiber, Stefan, Schumm, L. Philip, Scott, Regan, Seielstad, Mark, Shah, Tejas, Sharma, Yashoda, Silverberg, Mark S., Simmons, Alison, Simms, Lisa A., Singh, Abhey, Skieceviciene, Jurgita, van Sommeren, Suzanne, Song, Kyuyoung, Sood, Ajit, Spain, Sarah L., Steinhart, A. Hillary, Stempak, Joanne M., Stronati, Laura, Sung, Joseph J.Y., Targan, Stephan R., Taylor, Kirstin M., Theatre, Emilie, Torkvist, Leif, Torres, Esther A., Tremelling, Mark, Uhlig, Holm H., Umeno, Junji, Vahedi, Homayon, Vasiliauskas, Eric, Velde, Anje ter, Ventham, Nicholas T., Vermeire, Severine, Verspaget, Hein W., De Vos, Martine, Walters, Thomas, Wang, Kai, Wang, Ming-Hsi, Weersma, Rinse K., Wei, Zhi, Whiteman, David, Wijmenga, Cisca, Wilson, David C., Winkelmann, Juliane, Wong, Sunny H., Xavier, Ramnik J., Yamazaki, Keiko, Yang, Suk-Kyun, Ye, Byong Duk, Zeissig, Sebastian, Zhang, Bin, Zhang, Clarence K., Zhang, Hu, Zhang, Wei, Zhao, Hongyu, Zhao, Zhen Z., Baumdick, Martin E., Niehrs, Annika, Schwerk, Maria, Hinrichs, Ole, Jordan-Paiz, Ana, Padoan, Benedetta, Wegner, Lucy H.M., Schloer, Sebastian, Zecher, Britta F., Malsy, Jakob, Joshi, Vinita R., Illig, Christin, Schröder-Schwarz, Jennifer, Möller, Kimberly J., Martin, Maureen P., Yuki, Yuko, Ozawa, Mikki, Sauter, Jürgen, Schmidt, Alexander H., Perez, Daniel, Giannou, Anastasios D., Carrington, Mary, Davis, Randall S., Schumacher, Udo, Sauter, Guido, Huber, Samuel, Puelles, Victor G., Melling, Nathaniel, Altfeld, Marcus, and Bunders, Madeleine J.

Published
2023
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9. Short-term anti-TNF therapy with surgical closure versus anti-TNF therapy alone for Crohn's perianal fistulas (PISA-II): long-term outcomes of an international, multicentre patient preference, randomised controlled trial

Author

Meima - van Praag, Elise M., Becker, Marte A.J., van Rijn, Kyra L., Wasmann, Karin A.T.G.M., Stoker, Jaap, D'Haens, Geert R.A.M., Ponsioen, Cyriel Y., Gecse, Krisztina B., Dijkgraaf, Marcel G.W., Spinelli, Antonino, Danese, Silvio, Bemelman, Willem A., and Buskens, Christianne J.

Published
2023
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10. Long-term efficacy of metal versus plastic stents in inoperable perihilar cholangiocarcinoma; a multicenter retrospective propensity score matched comparison

Author

Fritzsche, Jeska A., de Jong, David M., Borremans, Jasmijn J.M.M., Bruno, Marco J., Van Delden, Otto M., Erdmann, Joris I., Fockens, Paul, de Gooyer, Peter G.M., Groot Koerkamp, Bas, Klümpen, Heinz-Josef, Moelker, Adriaan, Montazeri, Nahid S.M., Nooijen, Lynn E., Ponsioen, Cyriel Y., Van Wanrooij, Roy L.J., van Driel, Lydi M.J.W., and Voermans, Rogier P.

Published
2023
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11. Effects of Vedolizumab in Patients With Primary Sclerosing Cholangitis and Inflammatory Bowel Diseases

Author

Lynch, Kate D, Chapman, Roger W, Keshav, Satish, Montano-Loza, Aldo J, Mason, Andrew L, Kremer, Andreas E, Vetter, Marcel, de Krijger, Manon, Ponsioen, Cyriel Y, Trivedi, Palak, Hirschfield, Gideon, Schramm, Christoph, Liu, Chung Heng, Bowlus, Christopher L, Estes, Derek J, Pratt, Daniel, Hedin, Charlotte, Bergquist, Annika, de Vries, Annemarie C, van der Woude, C Janneke, Yu, Lei, Assis, David N, Boyer, James, Ytting, Henriette, Hallibasic, Emina, Trauner, Michael, Marschall, Hanns-Ulrich, Daretti, Luigi M, Marzioni, Marco, Yimam, Kidist K, Perin, Nicola, Floreani, Annarosa, Beretta-Piccoli, Benedetta Terziroli, Rogers, Jennifer K, Group, International Primary Sclerosing Cholangitis Study, and Levy, Cynthia

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Digestive Diseases - (Gallbladder), Liver Disease, Digestive Diseases, Inflammatory Bowel Disease, Autoimmune Disease, Chronic Liver Disease and Cirrhosis, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Oral and gastrointestinal, Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Humanized, Child, Cholangitis, Sclerosing, Gastrointestinal Agents, Humans, Inflammatory Bowel Diseases, Integrins, Liver Function Tests, Middle Aged, Retrospective Studies, Young Adult, Cholestatic Liver Disease, Ulcerative Colitis, Crohn's Disease, Integrin alpha4beta7, International Primary Sclerosing Cholangitis Study Group, Crohn’s Disease, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background & aimsGut-homing lymphocytes that express the integrin α4β7 and CCR9 might contribute to development of primary sclerosing cholangitis (PSC). Vedolizumab, which blocks the integrin α4β7, is used to treat patients with inflammatory bowel diseases (IBD), but there are few data on its efficacy in patients with PSC. We investigated the effects of vedolizumab in a large international cohort of patients with PSC and IBD.MethodsWe collected data from European and North American centers participating in the International PSC Study Group from patients with PSC and IBD who received at least 3 doses of vedolizumab (n = 102; median vedolizumab treatment duration, 412 days). Demographic and clinical data were collected from baseline and during the follow-up period (until liver transplantation, death, or 56 days after the final vedolizumab infusion). We analyzed overall changes in biochemical features of liver and proportions of patients with reductions in serum levels of alkaline phosphatase (ALP) of 20% or more, from baseline through last follow-up evaluation. Other endpoints included response of IBD to treatment (improved, unchanged, or worsened, judged by the treating clinician, as well as endoscopic score) and liver-related outcomes.ResultsIn the entire cohort, the median serum level of ALP increased from 1.54-fold the upper limit of normal at baseline to 1.64-fold the upper limit of normal at the last follow-up examination (P = .018); serum levels of transaminases and bilirubin also increased by a small amount between baseline and the last follow-up examination. Serum levels of ALP decreased by 20% or more in 21 patients (20.6%); only the presence of cirrhosis (odds ratio, 4.48; P = .019) was independently associated with this outcome. Of patients with available endoscopic data, 56.8% had a response of IBD to treatment. Liver-related events occurred in 21 patients (20.6%), including bacterial cholangitis, cirrhosis decompensation, or transplantation.ConclusionsIn an analysis of patients with PSC and IBD in an international study group, we found no evidence for a biochemical response to vedolizumab, although serum level of ALP decreased by 20% or more in a subset of patients. Vedolizumab appears to be well tolerated and the overall response of IBD was the same as expected for patients without PSC.

Published
2020

13. Drivers and determinants of strain dynamics following fecal microbiota transplantation

Author

Schmidt, Thomas S. B., Li, Simone S., Maistrenko, Oleksandr M., Akanni, Wasiu, Coelho, Luis Pedro, Dolai, Sibasish, Fullam, Anthony, Glazek, Anna M., Hercog, Rajna, Herrema, Hilde, Jung, Ferris, Kandels, Stefanie, Orakov, Askarbek, Thielemann, Roman, von Stetten, Moritz, Van Rossum, Thea, Benes, Vladimir, Borody, Thomas J., de Vos, Willem M., Ponsioen, Cyriel Y., Nieuwdorp, Max, and Bork, Peer

Published
2022
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14. Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility

Author

Sazonovs, Aleksejs, Stevens, Christine R., Venkataraman, Guhan R., Yuan, Kai, Avila, Brandon, Abreu, Maria T., Ahmad, Tariq, Allez, Matthieu, Ananthakrishnan, Ashwin N., Atzmon, Gil, Baras, Aris, Barrett, Jeffrey C., Barzilai, Nir, Beaugerie, Laurent, Beecham, Ashley, Bernstein, Charles N., Bitton, Alain, Bokemeyer, Bernd, Chan, Andrew, Chung, Daniel, Cleynen, Isabelle, Cosnes, Jacques, Cutler, David J., Daly, Allan, Damas, Oriana M., Datta, Lisa W., Dawany, Noor, Devoto, Marcella, Dodge, Sheila, Ellinghaus, Eva, Fachal, Laura, Farkkila, Martti, Faubion, William, Ferreira, Manuel, Franchimont, Denis, Gabriel, Stacey B., Ge, Tian, Georges, Michel, Gettler, Kyle, Giri, Mamta, Glaser, Benjamin, Goerg, Siegfried, Goyette, Philippe, Graham, Daniel, Hämäläinen, Eija, Haritunians, Talin, Heap, Graham A., Hiltunen, Mikko, Hoeppner, Marc, Horowitz, Julie E., Irving, Peter, Iyer, Vivek, Jalas, Chaim, Kelsen, Judith, Khalili, Hamed, Kirschner, Barbara S., Kontula, Kimmo, Koskela, Jukka T., Kugathasan, Subra, Kupcinskas, Juozas, Lamb, Christopher A., Laudes, Matthias, Lévesque, Chloé, Levine, Adam P., Lewis, James D., Liefferinckx, Claire, Loescher, Britt-Sabina, Louis, Edouard, Mansfield, John, May, Sandra, McCauley, Jacob L., Mengesha, Emebet, Mni, Myriam, Moayyedi, Paul, Moran, Christopher J., Newberry, Rodney D., O’Charoen, Sirimon, Okou, David T., Oldenburg, Bas, Ostrer, Harry, Palotie, Aarno, Paquette, Jean, Pekow, Joel, Peter, Inga, Pierik, Marieke J., Ponsioen, Cyriel Y., Pontikos, Nikolas, Prescott, Natalie, Pulver, Ann E., Rahmouni, Souad, Rice, Daniel L., Saavalainen, Päivi, Sands, Bruce, Sartor, R. Balfour, Schiff, Elena R., Schreiber, Stefan, Schumm, L. Philip, Segal, Anthony W., Seksik, Philippe, Shawky, Rasha, Sheikh, Shehzad Z., Silverberg, Mark S., Simmons, Alison, Skeiceviciene, Jurgita, Sokol, Harry, Solomonson, Matthew, Somineni, Hari, Sun, Dylan, Targan, Stephan, Turner, Dan, Uhlig, Holm H., van der Meulen, Andrea E., Vermeire, Séverine, Verstockt, Sare, Voskuil, Michiel D., Winter, Harland S., Young, Justine, Duerr, Richard H., Franke, Andre, Brant, Steven R., Cho, Judy, Weersma, Rinse K., Parkes, Miles, Xavier, Ramnik J., Rivas, Manuel A., Rioux, John D., McGovern, Dermot P. B., Huang, Hailiang, Anderson, Carl A., and Daly, Mark J.

Published
2022
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15. The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality

Author

Karlsen, Tom H, Sheron, Nick, Zelber-Sagi, Shira, Carrieri, Patrizia, Dusheiko, Geoffrey, Bugianesi, Elisabetta, Pryke, Rachel, Hutchinson, Sharon J, Sangro, Bruno, Martin, Natasha K, Cecchini, Michele, Dirac, Mae Ashworth, Belloni, Annalisa, Serra-Burriel, Miquel, Ponsioen, Cyriel Y, Sheena, Brittney, Lerouge, Alienor, Devaux, Marion, Scott, Nick, Hellard, Margaret, Verkade, Henkjan J, Sturm, Ekkehard, Marchesini, Giulio, Yki-Järvinen, Hannele, Byrne, Chris D, Targher, Giovanni, Tur-Sinai, Aviad, Barrett, Damon, Ninburg, Michael, Reic, Tatjana, Taylor, Alison, Rhodes, Tim, Treloar, Carla, Petersen, Claus, Schramm, Christoph, Flisiak, Robert, Simonova, Marieta Y, Pares, Albert, Johnson, Philip, Cucchetti, Alessandro, Graupera, Isabel, Lionis, Christos, Pose, Elisa, Fabrellas, Núria, Ma, Ann T, Mendive, Juan M, Mazzaferro, Vincenzo, Rutter, Harry, Cortez-Pinto, Helena, Kelly, Deirdre, Burton, Robyn, Lazarus, Jeffrey V, Ginès, Pere, Buti, Maria, Newsome, Philip N, Burra, Patrizia, and Manns, Michael P

Published
2022
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16. Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis

Author

Alberts, Rudi, de Vries, Elisabeth MG, Goode, Elizabeth C, Jiang, Xiaojun, Sampaziotis, Fotis, Rombouts, Krista, Böttcher, Katrin, Folseraas, Trine, Weismüller, Tobias J, Mason, Andrew L, Wang, Weiwei, Alexander, Graeme, Alvaro, Domenico, Bergquist, Annika, Björkström, Niklas K, Beuers, Ulrich, Björnsson, Einar, Boberg, Kirsten Muri, Bowlus, Christopher L, Bragazzi, Maria C, Carbone, Marco, Chazouillères, Olivier, Cheung, Angela, Dalekos, Georgios, Eaton, John, Eksteen, Bertus, Ellinghaus, David, Färkkilä, Martti, Festen, Eleonora AM, Floreani, Annarosa, Franceschet, Irene, Gotthardt, Daniel Nils, Hirschfield, Gideon M, Hoek, B van, Holm, Kristian, Hohenester, Simon, Hov, Johannes Roksund, Imhann, Floris, Invernizzi, Pietro, Juran, Brian D, Lenzen, Henrike, Lieb, Wolfgang, Liu, Jimmy Z, Marschall, Hanns-Ulrich, Marzioni, Marco, Melum, Espen, Milkiewicz, Piotr, Müller, Tobias, Pares, Albert, Rupp, Christian, Rust, Christian, Sandford, Richard N, Schramm, Christoph, Schreiber, Stefan, Schrumpf, Erik, Silverberg, Mark S, Srivastava, Brijesh, Sterneck, Martina, Teufel, Andreas, Vallier, Ludovic, Verheij, Joanne, Vila, Arnau Vich, Vries, Boudewijn de, Zachou, Kalliopi, Chapman, Roger W, Manns, Michael P, Pinzani, Massimo, Rushbrook, Simon M, Lazaridis, Konstantinos N, Franke, Andre, Anderson, Carl A, Karlsen, Tom H, Ponsioen, Cyriel Y, and Weersma, Rinse K

Subjects
Genetics, Transplantation, Chronic Liver Disease and Cirrhosis, Liver Disease, Clinical Research, Rare Diseases, Digestive Diseases - (Gallbladder), Digestive Diseases, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Adult, Cholangitis, Sclerosing, Cohort Studies, Disease Progression, Female, Humans, Kaplan-Meier Estimate, Logistic Models, Male, Middle Aged, Polymorphism, Single Nucleotide, Proportional Hazards Models, Thrombospondins, International PSC Study Group, The UK PSC Consortium, Primary sclerosing cholangitis, genetics, liver transplantation, Clinical Sciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology
Abstract

ObjectivePrimary sclerosing cholangitis (PSC) is a genetically complex, inflammatory bile duct disease of largely unknown aetiology often leading to liver transplantation or death. Little is known about the genetic contribution to the severity and progression of PSC. The aim of this study is to identify genetic variants associated with PSC disease progression and development of complications.DesignWe collected standardised PSC subphenotypes in a large cohort of 3402 patients with PSC. After quality control, we combined 130 422 single nucleotide polymorphisms of all patients-obtained using the Illumina immunochip-with their disease subphenotypes. Using logistic regression and Cox proportional hazards models, we identified genetic variants associated with binary and time-to-event PSC subphenotypes.ResultsWe identified genetic variant rs853974 to be associated with liver transplant-free survival (p=6.07×10-9). Kaplan-Meier survival analysis showed a 50.9% (95% CI 41.5% to 59.5%) transplant-free survival for homozygous AA allele carriers of rs853974 compared with 72.8% (95% CI 69.6% to 75.7%) for GG carriers at 10 years after PSC diagnosis. For the candidate gene in the region, RSPO3, we demonstrated expression in key liver-resident effector cells, such as human and murine cholangiocytes and human hepatic stellate cells.ConclusionWe present a large international PSC cohort, and report genetic loci associated with PSC disease progression. For liver transplant-free survival, we identified a genome-wide significant signal and demonstrated expression of the candidate gene RSPO3 in key liver-resident effector cells. This warrants further assessments of the role of this potential key PSC modifier gene.

Published
2018

17. THU-138 The male-to-female ratio among patients with primary biliary cholangitis depends on age

Author

Werner, Ellen, primary, de Veer, Rozanne C., additional, van Hooff, Maria C., additional, Beuers, Ulrich, additional, Drenth, Joost P.H., additional, Cuperus, Frans J.C., additional, van Hoek, Bart, additional, Veldt, Bart J., additional, Kempt-Kropp, Michael, additional, van Meer, Suzanne, additional, Verdonk, Robert C., additional, Flink, Hajo J., additional, Vrolijk, Jan Maarten, additional, Gevers, Tom J.G., additional, Ponsioen, Cyriel Y., additional, Borg, Martijn J. ter, additional, Soufidi, Khalida, additional, Boersma, Femke, additional, de Jonge, Hendrik J.M., additional, Wolfhagen, Frank H.J., additional, Baak, L.C., additional, Onderwater, Susanne L., additional, van Bergeijk, Jeroen D., additional, van Putten, Paul G., additional, de Bruin, Gijs J., additional, Adang, Rob P.R., additional, Pages, Nieves Aparicio, additional, de Boer, Wink, additional, Borg, Frank ter, additional, van Soest, Hanneke, additional, Janssen, Harry L.A., additional, Hansen, Bettina E., additional, Erler, Nicole S., additional, and van der Meer, Adriaan J., additional

Published
2024
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18. Incidence and prevalence of primary biliary cholangitis in the Netherlands – a nationwide cohort study

Author

de Veer, Rozanne C., primary, van Hooff, Maria C.B., additional, Werner, Ellen, additional, Beuers, Ulrich, additional, Drenth, Joost P.H., additional, Cuperus, Frans J.C., additional, van Hoek, Bart, additional, Veldt, Bart J., additional, Klemt-Kropp, Michael, additional, van Meer, Suzanne, additional, Verdonk, Robert C., additional, Flink, Hajo J., additional, Vrolijk, Jan Maarten, additional, Gevers, Tom J.G., additional, Ponsioen, Cyriel Y., additional, ter Borg, Martijn J., additional, Soufidi, Khalida, additional, Boersma, Femke, additional, de Jonge, Hendrik J.M., additional, Wolfhagen, Frank H.J., additional, Baak, L.C., additional, Onderwater, Susanne L., additional, van Bergeijk, Jeroen D., additional, van Putten, Paul G., additional, de Bruin, Gijs J., additional, Adang, Rob P.R., additional, Aparicio-Pages, Maria N., additional, de Boer, Wink, additional, Borg, Frank ter, additional, van Soest, Hanneke, additional, Janssen, Harry L.A., additional, Hansen, Bettina E., additional, Erler, Nicole S., additional, van der Meer, Adriaan J., additional, Abraham, Sunje, additional, Aktas, Huseyin, additional, Alderlieste, Yasser A., additional, Baak, L. (Bert) C., additional, Baven-Pronk, Martine A.M.C., additional, van der Beek, A.Sander, additional, Bekkering, Frank C., additional, Beukema, Menno, additional, Boonstra, Kirsten, additional, ter Borg, Frank, additional, ter Borg, Pieter C.J., additional, Bus, Paul J., additional, Cahen, Djuna L., additional, Cazemier, Marcel, additional, van Dam, Lisette J.H., additional, Denters, Maaike J., additional, Epping, Ludger S.M., additional, Friederich, Philip W., additional, van Gerven, Nicole F.M., additional, van den Hazel, Sven J., additional, van Hooff, Maria C., additional, Hotho, Daphne M., additional, Jurgens, Matthias C., additional, van Kemenade, J.Netty, additional, Kerbert-Dreteler, Marjo J., additional, Konings, Ingrid C.A.W., additional, de Kort, Sander, additional, Kuiper, Edith M.M., additional, Kuyvenhoven, Johan P.H., additional, Oterdoom, Leendert H., additional, van Rooij, Janne E., additional, Roomer, Robert, additional, Schmidt-Böhmer, Johannes, additional, Schmittgens, Stephan, additional, Schreuder, Tim C.M.A., additional, Nicolaas, Jerome Sint, additional, van Stiphout, Stephan H.C., additional, Thio, Hans H.K., additional, Tielemans, Merel M., additional, Vandebosch, Sigrid, additional, de Veer, Rozanne C., additional, Vree, J. Marleen de, additional, de Vries, Elsemieke, additional, Vrieze, Anne, additional, van der Waaij, Laurens A., additional, and de Wit, Ulrike, additional

Published
2024
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19. THU-100 Factors associated with the real-world biochemical response to fibrate therapy in primary biliary cholangitis

Author

van Hooff, Maria C., primary, de Veer, Rozanne C., additional, Werner, Ellen, additional, Beuers, Ulrich, additional, Drenth, Joost P.H., additional, Cuperus, Frans J.C., additional, van Hoek, Bart, additional, Veldt, Bart J., additional, Klemt-Kropp, Michael, additional, van Meer, Suzanne, additional, Verdonk, Robert C., additional, Flink, Hajo J., additional, Vrolijk, Jan Maarten, additional, Gevers, Tom J.G., additional, Ponsioen, Cyriel Y., additional, van Rooij, Janne, additional, Kerbert-Dreteler, Marjo J., additional, Nicolaas, Jerome Sint, additional, De Vree, Marleen, additional, de Vries, Elsemieke S., additional, Friederich, Philip W., additional, Tielemans, Merel M., additional, Aktas, Huseyin, additional, Hotho, Daphne M., additional, de Wit, Ulrike, additional, Kuyvenhoven, Johan P.H., additional, Abraham, Sunje, additional, Kuiper, Edith M.M., additional, Schmittgens, Stephan, additional, Alderslieste, Yasser A., additional, Janssen, Harry L.A., additional, Hansen, Bettina E., additional, Erler, Nicole S., additional, and van der Meer, Adriaan J., additional

Published
2024
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20. THU-120-YI The impact of ursodeoxycholic acid on biochemistry of patients with primary biliary cholangitis in a nationwide cohort

Author

Werner, Ellen, primary, van Hooff, Maria C., additional, van der Maas, Gerjan J., additional, de Veer, Rozanne C., additional, Beuers, Ulrich, additional, Drenth, Joost P.H., additional, Cuperus, Frans J.C., additional, van Hoek, Bart, additional, Veldt, Bart J., additional, Klemt-Kropp, Michael, additional, van Meer, Suzanne, additional, Verdonk, Robert C., additional, Flink, Hajo J., additional, Vrolijk, Jan Maarten, additional, Gevers, Tom J.G., additional, Ponsioen, Cyriel Y., additional, de Kort, Sander, additional, van Putten, Paul G., additional, Cahen, Djuna L., additional, van der Waaij, Lauren A., additional, Thio, Hans H.K., additional, Schreuder, Tim C.M.A., additional, van Dam, Lisette J.H., additional, Epping, Ludger S.M., additional, Jurgens, Matthias C., additional, Cazemier, Marcel, additional, van Kemenade, J., additional, Kuiper, Edith M.M., additional, Beukema, Menno, additional, Borg, Martijn J. ter, additional, Soufidi, Khalida, additional, Janssen, Harry L.A., additional, Hansen, Bettina E., additional, Erler, Nicole S., additional, and van der Meer, Adriaan J., additional

Published
2024
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22. Geographical region and clinical outcomes of patients with primary biliary cholangitis from Western Europe

Author

Murillo Perez, Carla F., Gerussi, Alessio, Trivedi, Palak J., Corpechot, Christophe, van der Meer, Adriaan J., Maria Battezzati, Pier, Lindor, Keith D., Nevens, Frederik, Kowdley, Kris V., Bruns, Tony, Cazzagon, Nora, Floreani, Annarosa, Tanaka, Atsushi, Ma, Xiong, Mason, Andrew L., Gulamhusein, Aliya, Ponsioen, Cyriel Y., Carbone, Marco, Lleo, Ana, Mayo, Marlyn J., Dalekos, George N., Gatselis, Nikolaos K., Thorburn, Douglas, Verhelst, Xavier, Parés, Albert, Janssen, Harry L.A., Hirschfield, Gideon M., Hansen, Bettina E., Invernizzi, Pietro, and Lammers, Willem J.

Published
2023
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23. Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis

Author

Weismüller, Tobias J, Trivedi, Palak J, Bergquist, Annika, Imam, Mohamad, Lenzen, Henrike, Ponsioen, Cyriel Y, Holm, Kristian, Gotthardt, Daniel, Färkkilä, Martti A, Marschall, Hanns-Ulrich, Thorburn, Douglas, Weersma, Rinse K, Fevery, Johan, Mueller, Tobias, Chazouillères, Olivier, Schulze, Kornelius, Lazaridis, Konstantinos N, Almer, Sven, Pereira, Stephen P, Levy, Cynthia, Mason, Andrew, Naess, Sigrid, Bowlus, Christopher L, Floreani, Annarosa, Halilbasic, Emina, Yimam, Kidist K, Milkiewicz, Piotr, Beuers, Ulrich, Huynh, Dep K, Pares, Albert, Manser, Christine N, Dalekos, George N, Eksteen, Bertus, Invernizzi, Pietro, Berg, Christoph P, Kirchner, Gabi I, Sarrazin, Christoph, Zimmer, Vincent, Fabris, Luca, Braun, Felix, Marzioni, Marco, Juran, Brian D, Said, Karouk, Rupp, Christian, Jokelainen, Kalle, de Valle, Maria Benito, Saffioti, Francesca, Cheung, Angela, Trauner, Michael, Schramm, Christoph, Chapman, Roger W, Karlsen, Tom H, Schrumpf, Erik, Strassburg, Christian P, Manns, Michael P, Lindor, Keith D, Hirschfield, Gideon M, Hansen, Bettina E, Boberg, Kirsten M, and Group, International PSC Study

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Autoimmune Disease, Clinical Research, Liver Disease, Digestive Diseases - (Gallbladder), Inflammatory Bowel Disease, Digestive Diseases, Rare Diseases, Crohn's Disease, Oral and gastrointestinal, Adult, Age Distribution, Australia, Chi-Square Distribution, Cholangitis, Sclerosing, Colitis, Ulcerative, Crohn Disease, Disease Progression, Europe, Female, Humans, Incidence, Kaplan-Meier Estimate, Liver Transplantation, Male, Middle Aged, Multivariate Analysis, North America, Phenotype, Prognosis, Proportional Hazards Models, Retrospective Studies, Risk Assessment, Risk Factors, Sex Distribution, Time Factors, Young Adult, Risk Stratification, Immune-Mediated Liver Disease, Autoimmune Liver Disease, Cholestasis, International PSC Study Group, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background & aimsPrimary sclerosing cholangitis (PSC) is an orphan hepatobiliary disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of disease progression based on distinct clinical phenotypes in a large international cohort of patients with PSC.MethodsWe performed a retrospective outcome analysis of patients diagnosed with PSC from 1980 through 2010 at 37 centers in Europe, North America, and Australia. For each patient, we collected data on sex, clinician-reported age at and date of PSC and IBD diagnoses, phenotypes of IBD and PSC, and date and indication of IBD-related surgeries. The primary and secondary endpoints were liver transplantation or death (LTD) and hepatopancreatobiliary malignancy, respectively. Cox proportional hazards models were applied to determine the effects of individual covariates on rates of clinical events, with time-to-event analysis ascertained through Kaplan-Meier estimates.ResultsOf the 7121 patients in the cohort, 2616 met the primary endpoint (median time to event of 14.5 years) and 721 developed hepatopancreatobiliary malignancy. The most common malignancy was cholangiocarcinoma (n = 594); patients of advanced age at diagnosis had an increased incidence compared with younger patients (incidence rate: 1.2 per 100 patient-years for patients younger than 20 years old, 6.0 per 100 patient-years for patients 21-30 years old, 9.0 per 100 patient-years for patients 31-40 years old, 14.0 per 100 patient-years for patients 41-50 years old, 15.2 per 100 patient-years for patients 51-60 years old, and 21.0 per 100 patient-years for patients older than 60 years). Of all patients with PSC studied, 65.5% were men, 89.8% had classical or large-duct disease, and 70.0% developed IBD at some point. Assessing the development of IBD as a time-dependent covariate, Crohn's disease and no IBD (both vs ulcerative colitis) were associated with a lower risk of LTD (unadjusted hazard ratio [HR], 0.62; P < .001 and HR, 0.90; P = .03, respectively) and malignancy (HR, 0.68; P = .008 and HR, 0.77; P = .004, respectively). Small-duct PSC was associated with a lower risk of LTD or malignancy compared with classic PSC (HR, 0.30 and HR, 0.15, respectively; both P < .001). Female sex was also associated with a lower risk of LTD or malignancy (HR, 0.88; P = .002 and HR, 0.68; P < .001, respectively). In multivariable analyses assessing the primary endpoint, small-duct PSC characterized a low-risk phenotype in both sexes (adjusted HR for men, 0.23; P < .001 and adjusted HR for women, 0.48; P = .003). Conversely, patients with ulcerative colitis had an increased risk of liver disease progression compared with patients with Crohn's disease (HR, 1.56; P < .001) or no IBD (HR, 1.15; P = .002).ConclusionsIn an analysis of data from individual patients with PSC worldwide, we found significant variation in clinical course associated with age at diagnosis, sex, and ductal and IBD subtypes. The survival estimates provided might be used to estimate risk levels for patients with PSC and select patients for clinical trials.

Published
2017

25. Incidence and prevalence of primary biliary cholangitis in the Netherlands – A nationwide cohort study

Author

de Veer, Rozanne C., van Hooff, Maria C., Werner, Ellen, Beuers, Ulrich, Drenth, Joost P.H., Cuperus, Frans J.C., van Hoek, Bart, Veldt, Bart J., Klemt-Kropp, Michael, van Meer, Suzanne, Verdonk, Robert C., Flink, Hajo J., Vrolijk, Jan Maarten, Gevers, Tom J.G., Ponsioen, Cyriel Y., ter Borg, Martijn J., Soufidi, Khalida, Boersma, Femke, de Jonge, Hendrik J.M., Wolfhagen, Frank H.J., Baak, L. C., Onderwater, Susanne L., van Bergeijk, Jeroen D., van Putten, Paul G., Adang, Rob P.R., Aparicio-Pages, Maria N., de Boer, Wink, ter Borg, Frank, van Soest, Hanneke, Janssen, Harry L.A., Hansen, Bettina E., Erler, Nicole S., van der Meer, Adriaan J., de Veer, Rozanne C., van Hooff, Maria C., Werner, Ellen, Beuers, Ulrich, Drenth, Joost P.H., Cuperus, Frans J.C., van Hoek, Bart, Veldt, Bart J., Klemt-Kropp, Michael, van Meer, Suzanne, Verdonk, Robert C., Flink, Hajo J., Vrolijk, Jan Maarten, Gevers, Tom J.G., Ponsioen, Cyriel Y., ter Borg, Martijn J., Soufidi, Khalida, Boersma, Femke, de Jonge, Hendrik J.M., Wolfhagen, Frank H.J., Baak, L. C., Onderwater, Susanne L., van Bergeijk, Jeroen D., van Putten, Paul G., Adang, Rob P.R., Aparicio-Pages, Maria N., de Boer, Wink, ter Borg, Frank, van Soest, Hanneke, Janssen, Harry L.A., Hansen, Bettina E., Erler, Nicole S., and van der Meer, Adriaan J.

Abstract

Background & Aims: Although primary biliary cholangitis (PBC) is considered a rare disorder, accurate determination of its incidence and prevalence remains challenging due to limited comprehensive population-based registries. We aimed to assess the incidence and prevalence of PBC in the Netherlands over time through the nationwide Dutch PBC Cohort Study (DPCS). Methods: DPCS retrospectively included every identifiable patient with PBC in the Netherlands from 1990 onwards in all 71 Dutch hospitals. Incidence and prevalence were assessed between 2008-2018 by Poisson regression between sex and age groups over time. Results: On the 1st of January 2008, there were 1,458 patients with PBC in the Netherlands. Between 2008-2018, 2,187 individuals were newly diagnosed, 46 were transplanted and 468 died. The yearly incidence of PBC in 2008 was 1.38, increasing to 1.74 per 100,000 persons in 2018. When compared to those aged <45 years, females aged 45-64 years (adjusted incidence rate ratio 4.21, 95% CI 3.76-4.71, p <0.001) and males ≥65 years (adjusted incidence rate ratio 14.41, 95% CI 9.62-21.60, p <0.001) were at the highest risk of being diagnosed with PBC. The male-to-female ratio of patients newly diagnosed with PBC during the study period was 1:14 in those <45 years, 1:10 in patients aged 45-64 years, and 1:4 in those ≥65 years. Point prevalence increased from 11.9 in 2008 to 21.5 per 100,000 persons in 2018. Average annual percent change in this time period was 5.94% (95% CI 5.77-6.15, p <0.05), and was the highest among the population aged ≥65 years (5.69%, 95% CI 5.32-6.36, p <0.001). Conclusions: In this nationwide cohort study, we observed an increase in both the incidence and prevalence of PBC in the Netherlands over the past decade, with marked age and sex differences. Impact and implications: This nationwide Dutch primary biliary

Published
2024

26. Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: retrospective long-term follow-up of the LIR!C trial

Author

Hart, Ailsa, Warusavitarne, Janindra, Van Bodegraven, Ad A., Brink, Menno A., Consten, Esther C.J., Van Wagensveld, Bart A., Rijk, Marno C.M., Crolla, Rogier M.P.H., Noomen, Casper G., Houdijk, Alexander P.J., Mallant, Rosalie C., Boom, Maarten, Marsman, Willem A., Stockmann, Hein B., De Groof, A. Jeroen, Bruin, Karlien, Maring, John, van Ditzhuijsen, Theo, Prins, Hubert, van den Brande, Jan, Kingma, Paul, van Geloven, Anna, de Boer, Nanne, van der Peet, Donald, Jansen, Jeroen, Gerhards, Michael, van der Woude, Janneke, Schouten, Ruud, Oldenburg, Bas, van Hillegersberg, Richard, West, Rachel, Mannaerts, Guido, Spanier, Marcel, Spillenaar Bilgen, Ernst Jan, Lieverse, Rob, van der Zaag, Edwin, Depla, Annekatrien, van de Laar, Arnold, Bolwerk, Clemens, Brouwer, Hans, Mahmmod, Nofel, Hazebroek, Eric, Vecht, Juda, Pierik, Robert, Dijkstra, Gerard, Hofker, Sijbrand, Uiterwaal, Tessa, Eijsbouts, Quirijn, Oostenbrug, Liekele, Sosef, Meindert, Cahen, Djuna, van der Werff, Sjoerd, Marinelli, Andreas, Peters, Job, Cense, Huib, Talstra, Nynke, Morar, Pritesh, Stevens, Toer W, Haasnoot, Maria L, D'Haens, Geert R, Buskens, Christianne J, de Groof, E Joline, Eshuis, Emma J, Gardenbroek, Tjibbe J, Mol, Bregje, Stokkers, Pieter C F, Bemelman, Willem A, and Ponsioen, Cyriel Y

Published
2020
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27. Effects of Tumor Necrosis Factor Antagonists in Patients With Primary Sclerosing Cholangitis

Author

Hedin, Charlotte Rose Hawkey, Sado, Gina, Ndegwa, Nelson, Lytvyak, Ellina, Mason, Andrew, Montano-Loza, Aldo, Gerussi, Alessio, Saffioti, Francesca, Thorburn, Douglas, Nilsson, Emma, Larsson, Geir, Moum, Bjørn A., van Munster, Kim N., Ponsioen, Cyriel Y., Levy, Cynthia, Nogueira, Nicholas F., Bowlus, Christopher L., Gotlieb, Neta, Shibolet, Oren, Lynch, Kate D., Chapman, Roger W., Rupp, Christian, Vesterhus, Mette, Jørgensen, Kristin K., Rorsman, Fredrik, Schramm, Christoph, Sabino, João, Vermeire, Severine, Zago, Alessandra, Cazzagon, Nora, Marschall, Hanns-Ulrich, Ytting, Henriette, Ben Belkacem, Karima, Chazouilleres, Olivier, Almer, Sven, and Bergquist, Annika

Published
2020
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28. Factors Associated With Progression and Outcomes of Early Stage Primary Biliary Cholangitis

Author

Gatselis, Nikolaos K., Goet, Jorn C., Zachou, Kalliopi, Lammers, Willem J., Janssen, Harry L.A., Hirschfield, Gideon, Corpechot, Christophe, Lindor, Keith D., Invernizzi, Pietro, Mayo, Marlyn J., Battezzati, Pier Maria, Floreani, Annarosa, Pares, Albert, Lygoura, Vasiliki, Nevens, Frederik, Mason, Andrew L., Kowdley, Kris V., Ponsioen, Cyriel Y., Bruns, Tony, Thorburn, Douglas, Verhelst, Xavier, Harms, Maren H., van Buuren, Henk R., Hansen, Bettina E., and Dalekos, George N.

Published
2020
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31. Dynamic Prediction of Advanced Colorectal Neoplasia in Inflammatory Bowel Disease

Author

Wijnands, Anouk M., primary, Penning de Vries, Bas B.L., additional, Lutgens, Maurice W.M.D., additional, Bakhshi, Zeinab, additional, Al Bakir, Ibrahim, additional, Beaugerie, Laurent, additional, Bernstein, Charles N., additional, Chang-ho Choi, Ryan, additional, Coelho-Prabhu, Nayantara, additional, Graham, Trevor A., additional, Hart, Ailsa L., additional, ten Hove, Joren R., additional, Itzkowitz, Steven H., additional, Kirchgesner, Julien, additional, Mooiweer, Erik, additional, Shaffer, Seth R., additional, Shah, Shailja C., additional, Elias, Sjoerd G., additional, Oldenburg, Bas, additional, van Bodegraven, Adriaan A., additional, Fidder, Herma H., additional, Hirdes, Meike M.C., additional, Hoentjen, Frank, additional, Jansen, Jeroen M., additional, Mahmmod, Nofel, additional, van der Meulen-de Jong, Andrea E., additional, Ponsioen, Cyriel Y., additional, van Schaik, Fiona D.M., additional, and van der Woude, C. Janneke, additional

Published
2024
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32. Per-oral cholangioscopy in patients with primary sclerosing cholangitis: a 12-month follow-up study

Author

Mohamed, Rachid, additional, Tejaswi, Sooraj, additional, Aabakken, Lars, additional, Ponsioen, Cyriel Y, additional, Bowlus, Christopher L, additional, Adler, Douglas G, additional, Forbes, Nauzer, additional, Paulsen, Vemund, additional, Voermans, Rogier P, additional, Urayama, Shiro, additional, Peetermans, Joyce, additional, Rousseau, Matthew J, additional, and Eksteen, Bertus, additional

Published
2024
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34. Effects of Age and Sex of Response to Ursodeoxycholic Acid and Transplant-free Survival in Patients With Primary Biliary Cholangitis

Author

Cheung, Angela C., Lammers, Willem J., Murillo Perez, Carla F., van Buuren, Henk R., Gulamhusein, Aliya, Trivedi, Palak J., Lazaridis, Konstantinos N., Ponsioen, Cyriel Y., Floreani, Annarosa, Hirschfield, Gideon M., Corpechot, Christophe, Mayo, Marlyn J., Invernizzi, Pietro, Battezzati, Pier Maria, Parés, Albert, Nevens, Frederik, Thorburn, Douglas, Mason, Andrew L., Carbone, Marco, Kowdley, Kris V., Bruns, Tony, Dalekos, George N., Gatselis, Nikolaos K., Verhelst, Xavier, Lindor, Keith D., Lleo, Ana, Poupon, Raoul, Janssen, Harry L.A., and Hansen, Bettina E.

Published
2019
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36. Ursodeoxycholic acid therapy and liver transplant-free survival in patients with primary biliary cholangitis

Author

Harms, Maren H., van Buuren, Henk R., Corpechot, Christophe, Thorburn, Douglas, Janssen, Harry L.A., Lindor, Keith D., Hirschfield, Gideon M., Parés, Albert, Floreani, Annarosa, Mayo, Marlyn J., Invernizzi, Pietro, Battezzati, Pier Maria, Nevens, Frederik, Ponsioen, Cyriel Y., Mason, Andrew L., Kowdley, Kris V., Lammers, Willem J., Hansen, Bettina E., and van der Meer, Adriaan J.

Published
2019
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38. Simplified care-pathway selection for nonspecialist practice: the GLOBAL Primary Biliary Cholangitis Study Group Age, Bilirubin, Alkaline phosphatase risk assessment tool

Author

Murillo Perez, Carla F., Gulamhusein, Aliya, Carbone, Marco, Trivedi, Palak J., van der Meer, Adriaan J., Corpechot, Christophe, Battezzati, Pier Maria, Lammers, Willem J., Cazzagon, Nora, Floreani, Annarosa, Parés, Albert, Nevens, Frederik, Lleo, Ana, Mayo, Marlyn J., Kowdley, Kris V., Ponsioen, Cyriel Y., Dalekos, George N., Gatselis, Nikolaos K., Thorburn, Douglas, Mason, Andrew L., Janssen, Harry, Verhelst, Xavier, Bruns, Tony, Lindor, Keith D., Chazouillères, Olivier, Invernizzi, Pietro, Hansen, Bettina E., and Hirschfield, Gideon M.

Published
2021
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41. No Superiority of Stents vs Balloon Dilatation for Dominant Strictures in Patients With Primary Sclerosing Cholangitis

Author

Ponsioen, Cyriel Y., Arnelo, Urban, Bergquist, Annika, Rauws, Erik A., Paulsen, Vemund, Cantú, Paolo, Parzanese, Ilaria, De Vries, Elisabeth M., van Munster, Kim N., Said, Karouk, Chazouillères, Olivier, Desaint, Benoit, Kemgang, Astrid, Färkkilä, Martti, Van der Merwe, Schalk, Van Steenbergen, Werner, Marschall, Hanns-Ulrich, Stotzer, Per-Ove, Thorburn, Douglas, Pereira, Stephen P., and Aabakken, Lars

Published
2018
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42. High Risk of Advanced Colorectal Neoplasia in Patients With Primary Sclerosing Cholangitis Associated With Inflammatory Bowel Disease

Author

Shah, Shailja C., ten Hove, Joren R., Castaneda, Daniel, Palmela, Carolina, Mooiweer, Erik, Colombel, Jean-Frédéric, Harpaz, Noam, Ullman, Thomas A., van Bodegraven, Ad A., Jansen, Jeroen M., Mahmmod, Nofel, van der Meulen-de Jong, Andrea E., Ponsioen, Cyriel Y., van der Woude, Christine J., Oldenburg, Bas, Itzkowitz, Steven H., and Torres, Joana

Published
2018
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43. Chromoendoscopy versus autofluorescence imaging for neoplasia detection in patients with longstanding ulcerative colitis (FIND-UC): an international, multicentre, randomised controlled trial

Author

Vleugels, Jasper L A, Rutter, Matt D, Ragunath, Krish, Rees, Colin J, Ponsioen, Cyriel Y, Lahiff, Conor, Ket, Shara N, Wanders, Linda K, Samuel, Sunil, Butt, Faheem, Kuiper, Teaco, Travis, Simon P L, D'Haens, Geert, Wang, Lai M, van Eeden, Susanne, East, James E, and Dekker, Evelien

Published
2018
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44. Association Between Variants of PRDM1 and NDP52 and Crohn's Disease, Based on Exome Sequencing and Functional Studies

Author

Ellinghaus, David, Zhang, Hu, Zeissig, Sebastian, Lipinski, Simone, Till, Andreas, Jiang, Tao, Stade, Björn, Bromberg, Yana, Ellinghaus, Eva, Keller, Andreas, Rivas, Manuel A, Skieceviciene, Jurgita, Doncheva, Nadezhda T, Liu, Xiao, Liu, Qing, Jiang, Fuman, Forster, Michael, Mayr, Gabriele, Albrecht, Mario, Häsler, Robert, Boehm, Bernhard O, Goodall, Jane, Berzuini, Carlo R, Lee, James, Andersen, Vibeke, Vogel, Ulla, Kupcinskas, Limas, Kayser, Manfred, Krawczak, Michael, Nikolaus, Susanna, Weersma, Rinse K, Ponsioen, Cyriel Y, Sans, Miquel, Wijmenga, Cisca, Strachan, David P, McArdle, Wendy L, Vermeire, Séverine, Rutgeerts, Paul, Sanderson, Jeremy D, Mathew, Christopher G, Vatn, Morten H, Wang, Jun, Nöthen, Markus M, Duerr, Richard H, Büning, Carsten, Brand, Stephan, Glas, Jürgen, Winkelmann, Juliane, Illig, Thomas, Latiano, Anna, Annese, Vito, Halfvarson, Jonas, D'Amato, Mauro, Daly, Mark J, Nothnagel, Michael, Karlsen, Tom H, Subramani, Suresh, Rosenstiel, Philip, Schreiber, Stefan, Parkes, Miles, and Franke, Andre

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Nutrition and Dietetics, Biotechnology, Genetics, Inflammatory Bowel Disease, Autoimmune Disease, Human Genome, Clinical Research, Digestive Diseases, Crohn's Disease, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Inflammatory and immune system, Adolescent, Adult, Case-Control Studies, Colitis, Ulcerative, Crohn Disease, Exome, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Mutation, Missense, Nuclear Proteins, Polymorphism, Single Nucleotide, Positive Regulatory Domain I-Binding Factor 1, Quantitative Trait Loci, Repressor Proteins, Young Adult, Whole-Exome Sequencing, Complex Disease, CD, Crohn’s disease, GWAS, IBD, IFN, NF-κB, PBL, PBMC, SNP, SNV, TLR, Toll-like receptor, UC, WT, eQTL, expression quantitative trait locus, genome-wide association studies, inflammatory bowel disease, interferon, nuclear factor κB, peripheral blood lymphocyte, peripheral blood mononuclear cell, qRT-PCR, quantitative reverse-transcription polymerase chain reaction, single nucleotide polymorphism, single nucleotide variant, ulcerative colitis, wild-type, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background & aimsGenome-wide association studies (GWAS) have identified 140 Crohn's disease (CD) susceptibility loci. For most loci, the variants that cause disease are not known and the genes affected by these variants have not been identified. We aimed to identify variants that cause CD through detailed sequencing, genetic association, expression, and functional studies.MethodsWe sequenced whole exomes of 42 unrelated subjects with CD and 5 healthy subjects (controls) and then filtered single nucleotide variants by incorporating association results from meta-analyses of CD GWAS and in silico mutation effect prediction algorithms. We then genotyped 9348 subjects with CD, 2868 subjects with ulcerative colitis, and 14,567 control subjects and associated variants analyzed in functional studies using materials from subjects and controls and in vitro model systems.ResultsWe identified rare missense mutations in PR domain-containing 1 (PRDM1) and associated these with CD. These mutations increased proliferation of T cells and secretion of cytokines on activation and increased expression of the adhesion molecule L-selectin. A common CD risk allele, identified in GWAS, correlated with reduced expression of PRDM1 in ileal biopsy specimens and peripheral blood mononuclear cells (combined P = 1.6 × 10(-8)). We identified an association between CD and a common missense variant, Val248Ala, in nuclear domain 10 protein 52 (NDP52) (P = 4.83 × 10(-9)). We found that this variant impairs the regulatory functions of NDP52 to inhibit nuclear factor κB activation of genes that regulate inflammation and affect the stability of proteins in Toll-like receptor pathways.ConclusionsWe have extended the results of GWAS and provide evidence that variants in PRDM1 and NDP52 determine susceptibility to CD. PRDM1 maps adjacent to a CD interval identified in GWAS and encodes a transcription factor expressed by T and B cells. NDP52 is an adaptor protein that functions in selective autophagy of intracellular bacteria and signaling molecules, supporting the role of autophagy in the pathogenesis of CD.

Published
2013

45. Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

Author

Liu, Jimmy Z, Hov, Johannes Roksund, Folseraas, Trine, Ellinghaus, Eva, Rushbrook, Simon M, Doncheva, Nadezhda T, Andreassen, Ole A, Weersma, Rinse K, Weismüller, Tobias J, Eksteen, Bertus, Invernizzi, Pietro, Hirschfield, Gideon M, Gotthardt, Daniel Nils, Pares, Albert, Ellinghaus, David, Shah, Tejas, Juran, Brian D, Milkiewicz, Piotr, Rust, Christian, Schramm, Christoph, Müller, Tobias, Srivastava, Brijesh, Dalekos, Georgios, Nöthen, Markus M, Herms, Stefan, Winkelmann, Juliane, Mitrovic, Mitja, Braun, Felix, Ponsioen, Cyriel Y, Croucher, Peter JP, Sterneck, Martina, Teufel, Andreas, Mason, Andrew L, Saarela, Janna, Leppa, Virpi, Dorfman, Ruslan, Alvaro, Domenico, Floreani, Annarosa, Onengut-Gumuscu, Suna, Rich, Stephen S, Thompson, Wesley K, Schork, Andrew J, Næss, Sigrid, Thomsen, Ingo, Mayr, Gabriele, König, Inke R, Hveem, Kristian, Cleynen, Isabelle, Gutierrez-Achury, Javier, Ricaño-Ponce, Isis, van Heel, David, Björnsson, Einar, Sandford, Richard N, Durie, Peter R, Melum, Espen, Vatn, Morten H, Silverberg, Mark S, Duerr, Richard H, Padyukov, Leonid, Brand, Stephan, Sans, Miquel, Annese, Vito, Achkar, Jean-Paul, Boberg, Kirsten Muri, Marschall, Hanns-Ulrich, Chazouillères, Olivier, Bowlus, Christopher L, Wijmenga, Cisca, Schrumpf, Erik, Vermeire, Severine, Albrecht, Mario, UK-PSCSC Consortium, Rioux, John D, Alexander, Graeme, Bergquist, Annika, Cho, Judy, Schreiber, Stefan, Manns, Michael P, Färkkilä, Martti, Dale, Anders M, Chapman, Roger W, Lazaridis, Konstantinos N, International PSC Study Group, Franke, Andre, Anderson, Carl A, Karlsen, Tom H, and International IBD Genetics Consortium

Subjects
UK-PSCSC Consortium, International PSC Study Group, International IBD Genetics Consortium, Humans, Cholangitis, Sclerosing, Oligonucleotide Array Sequence Analysis, Risk Factors, Case-Control Studies, Gene Frequency, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Genetic Loci, Genetic Pleiotropy, Genotyping Techniques, Developmental Biology, Biological Sciences, Medical and Health Sciences
Abstract

Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation. We compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip. We identified 12 genome-wide significant associations outside the human leukocyte antigen (HLA) complex, 9 of which were new, increasing the number of known PSC risk loci to 16. Despite comorbidity with inflammatory bowel disease (IBD) in 72% of the cases, 6 of the 12 loci showed significantly stronger association with PSC than with IBD, suggesting overlapping yet distinct genetic architectures for these two diseases. We incorporated association statistics from 7 diseases clinically occurring with PSC in the analysis and found suggestive evidence for 33 additional pleiotropic PSC risk loci. Together with network analyses, these findings add to the genetic risk map of PSC and expand on the relationship between PSC and other immune-mediated diseases.

Published
2013

47. Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

Author

Jostins, Luke, Ripke, Stephan, Weersma, Rinse K, Duerr, Richard H, McGovern, Dermot P, Hui, Ken Y, Lee, James C, Philip Schumm, L, Sharma, Yashoda, Anderson, Carl A, Essers, Jonah, Mitrovic, Mitja, Ning, Kaida, Cleynen, Isabelle, Theatre, Emilie, Spain, Sarah L, Raychaudhuri, Soumya, Goyette, Philippe, Wei, Zhi, Abraham, Clara, Achkar, Jean-Paul, Ahmad, Tariq, Amininejad, Leila, Ananthakrishnan, Ashwin N, Andersen, Vibeke, Andrews, Jane M, Baidoo, Leonard, Balschun, Tobias, Bampton, Peter A, Bitton, Alain, Boucher, Gabrielle, Brand, Stephan, Büning, Carsten, Cohain, Ariella, Cichon, Sven, D’Amato, Mauro, De Jong, Dirk, Devaney, Kathy L, Dubinsky, Marla, Edwards, Cathryn, Ellinghaus, David, Ferguson, Lynnette R, Franchimont, Denis, Fransen, Karin, Gearry, Richard, Georges, Michel, Gieger, Christian, Glas, Jürgen, Haritunians, Talin, Hart, Ailsa, Hawkey, Chris, Hedl, Matija, Hu, Xinli, Karlsen, Tom H, Kupcinskas, Limas, Kugathasan, Subra, Latiano, Anna, Laukens, Debby, Lawrance, Ian C, Lees, Charlie W, Louis, Edouard, Mahy, Gillian, Mansfield, John, Morgan, Angharad R, Mowat, Craig, Newman, William, Palmieri, Orazio, Ponsioen, Cyriel Y, Potocnik, Uros, Prescott, Natalie J, Regueiro, Miguel, Rotter, Jerome I, Russell, Richard K, Sanderson, Jeremy D, Sans, Miquel, Satsangi, Jack, Schreiber, Stefan, Simms, Lisa A, Sventoraityte, Jurgita, Targan, Stephan R, Taylor, Kent D, Tremelling, Mark, Verspaget, Hein W, De Vos, Martine, Wijmenga, Cisca, Wilson, David C, Winkelmann, Juliane, Xavier, Ramnik J, Zeissig, Sebastian, Zhang, Bin, Zhang, Clarence K, Zhao, Hongyu, Silverberg, Mark S, Annese, Vito, Hakonarson, Hakon, Brant, Steven R, Radford-Smith, Graham, Mathew, Christopher G, Rioux, John D, and Schadt, Eric E

Subjects
Epidemiology, Biological Sciences, Health Sciences, Genetics, Digestive Diseases, Human Genome, Inflammatory Bowel Disease, Biotechnology, Autoimmune Disease, Crohn's Disease, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Oral and gastrointestinal, Colitis, Ulcerative, Crohn Disease, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Haplotypes, Host-Pathogen Interactions, Humans, Inflammatory Bowel Diseases, Mycobacterium, Mycobacterium Infections, Mycobacterium tuberculosis, Phenotype, Polymorphism, Single Nucleotide, Reproducibility of Results, International IBD Genetics Consortium, General Science & Technology
Abstract

Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other populations. Genome-wide association studies and subsequent meta-analyses of these two diseases as separate phenotypes have implicated previously unsuspected mechanisms, such as autophagy, in their pathogenesis and showed that some IBD loci are shared with other inflammatory diseases. Here we expand on the knowledge of relevant pathways by undertaking a meta-analysis of Crohn's disease and ulcerative colitis genome-wide association scans, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls. We identify 71 new associations, for a total of 163 IBD loci, that meet genome-wide significance thresholds. Most loci contribute to both phenotypes, and both directional (consistently favouring one allele over the course of human history) and balancing (favouring the retention of both alleles within populations) selection effects are evident. Many IBD loci are also implicated in other immune-mediated disorders, most notably with ankylosing spondylitis and psoriasis. We also observe considerable overlap between susceptibility loci for IBD and mycobacterial infection. Gene co-expression network analysis emphasizes this relationship, with pathways shared between host responses to mycobacteria and those predisposing to IBD.

Published
2012

48. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

Author

Anderson, Carl A, Boucher, Gabrielle, Lees, Charlie W, Franke, Andre, D'Amato, Mauro, Taylor, Kent D, Lee, James C, Goyette, Philippe, Imielinski, Marcin, Latiano, Anna, Lagacé, Caroline, Scott, Regan, Amininejad, Leila, Bumpstead, Suzannah, Baidoo, Leonard, Baldassano, Robert N, Barclay, Murray, Bayless, Theodore M, Brand, Stephan, Büning, Carsten, Colombel, Jean-Frédéric, Denson, Lee A, De Vos, Martine, Dubinsky, Marla, Edwards, Cathryn, Ellinghaus, David, Fehrmann, Rudolf SN, Floyd, James AB, Florin, Timothy, Franchimont, Denis, Franke, Lude, Georges, Michel, Glas, Jürgen, Glazer, Nicole L, Guthery, Stephen L, Haritunians, Talin, Hayward, Nicholas K, Hugot, Jean-Pierre, Jobin, Gilles, Laukens, Debby, Lawrance, Ian, Lémann, Marc, Levine, Arie, Libioulle, Cecile, Louis, Edouard, McGovern, Dermot P, Milla, Monica, Montgomery, Grant W, Morley, Katherine I, Mowat, Craig, Ng, Aylwin, Newman, William, Ophoff, Roel A, Papi, Laura, Palmieri, Orazio, Peyrin-Biroulet, Laurent, Panés, Julián, Phillips, Anne, Prescott, Natalie J, Proctor, Deborah D, Roberts, Rebecca, Russell, Richard, Rutgeerts, Paul, Sanderson, Jeremy, Sans, Miquel, Schumm, Philip, Seibold, Frank, Sharma, Yashoda, Simms, Lisa A, Seielstad, Mark, Steinhart, A Hillary, Targan, Stephan R, van den Berg, Leonard H, Vatn, Morten, Verspaget, Hein, Walters, Thomas, Wijmenga, Cisca, Wilson, David C, Westra, Harm-Jan, Xavier, Ramnik J, Zhao, Zhen Z, Ponsioen, Cyriel Y, Andersen, Vibeke, Torkvist, Leif, Gazouli, Maria, Anagnou, Nicholas P, Karlsen, Tom H, Kupcinskas, Limas, Sventoraityte, Jurgita, Mansfield, John C, Kugathasan, Subra, Silverberg, Mark S, Halfvarson, Jonas, Rotter, Jerome I, Mathew, Christopher G, Griffiths, Anne M, Gearry, Richard, Ahmad, Tariq, Brant, Steven R, and Chamaillard, Mathias

Subjects
Biological Sciences, Genetics, Autoimmune Disease, Human Genome, Crohn's Disease, Digestive Diseases, Nutrition, Inflammatory Bowel Disease, Prevention, Oral and gastrointestinal, Colitis, Ulcerative, Crohn Disease, Genome-Wide Association Study, Humans, Risk, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 × 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.

Published
2011

50. Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: a randomised controlled, open-label, multicentre trial

Author

Bruin, Karlien, Maring, John, van Ditzhuijsen, Theo, Prins, Hubert, van den Brande, Jan, Kingma, Paul, van Geloven, Anna, de Boer, Nanne, van der Peet, Donald, Jansen, Jeroen, Gerhards, Michael, van der Woude, Janneke, Schouten, Ruud, Oldenburg, Bas, van Hillegersberg, Richard, West, Rachel, Mannaerts, Guido, Spanier, Marcel, Spillenaar Bilgen, Ernst Jan, Lieverse, Rob, van der Zaag, Edwin, Depla, Annekatrien, van de Laar, Arnold, Bolwerk, Clemens, Brouwer, Hans, Mahmmod, Nofel, Hazebroek, Eric, Vecht, Juda, Pierik, Robert, Dijkstra, Gerard, Hofker, Sijbrand, Uiterwaal, Tessa, Eijsbouts, Quirijn, Oostenbrug, Liekele, Sosef, Meindert, Cahen, Djuna, van der Werff, Sjoerd, Marinelli, Andreas, Peters, Job, Cense, Huib, Talstra, Nynke, Morar, Pritesh, Ponsioen, Cyriel Y, de Groof, E Joline, Eshuis, Emma J, Gardenbroek, Tjibbe J, Bossuyt, Patrick M M, Hart, Ailsa, Warusavitarne, Janindra, Buskens, Christianne J, van Bodegraven, Ad A, Brink, Menno A, Consten, Esther C J, van Wagensveld, Bart A, Rijk, Marno C M, Crolla, Rogier M P H, Noomen, Casper G, Houdijk, Alexander P J, Mallant, Rosalie C, Boom, Maarten, Marsman, Willem A, Stockmann, Hein B, Mol, Bregje, de Groof, A Jeroen, Stokkers, Pieter C, D'Haens, Geert R, and Bemelman, Willem A

Published
2017
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