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1. Bone Regeneration Potential of Biphasic Nanocalcium Phosphate with High Hydroxyapatite/Tricalcium Phosphate Ratios in Rabbit Calvarial Defects.

Author

Prisana Pripatnanont, Pongsakorn Praserttham, Srisurang Suttapreyasri, Narit Leepong, and Naruporn Monmaturapoj

Subjects
THERAPEUTICS, ANIMAL experimentation, AUTOGRAFTS, BONE regeneration, BONE substitutes, PHOSPHATES, PROBABILITY theory, RABBITS, RESEARCH funding, SKULL, T-test (Statistics), CALCIUM compounds, SAMPLE size (Statistics), DATA analysis software, ONE-way analysis of variance
Abstract

Purpose: This study aimed to evaluate the effect of biphasic calcium phosphate (BCP) with high hydroxyapatite/tricalcium phosphate (HA/TCP) ratios on bone formation in rabbit calvarial defects. Materials and Methods: Sixteen New Zealand white rabbits were randomly divided into two groups, a control group and an experimental group. In each animal, bilateral circular defects (10-mm diameter) were created on the calvarium. In the control group (three rabbits per time frame), defects were grafted with autogenous bone chips in one side and left empty in the other side. In the experimental group (five rabbits per time frame), defects were grafted with BCP1 (HA:TCP, 8:2) in one side and BCP2 (HA:TCP, 9:1) in the contralateral side. The animals were sacrificed at 2 and 8 weeks as designated. Bone formation and residual grafting material were assessed by radiographic densitometry, microcomputed tomography (micro-CT), and histomorphometric analysis. Results: Histologic observation revealed that BCP1, BCP2, and the autogenous bone group preserved good contours of the defect, while the unfilled defect group showed connective tissue healing. Micro-CT analysis at 8 weeks showed the comparable percentages of bone volume fraction (% BV/TV) of BCPI (20.70% ± 2.76%) and BCP2 (20.72% ± 3.97%) and two times higher than that of 2 weeks (9.90% ± 0.75%, 10.57%> ± 0.85%). The autogenous group had a significantly (P < .005) greater % BV/TV (34.58%o ± 8.85%) than other groups. The percentage of the material volume fraction of BCP1 and BCP2 was not different. The histomorphometry demonstrated a higher increase in newly formed bone from 2 to 8 weeks in all groups, and all were comparable (autogenous: 4.30% ± 0.76%, 12.83% ± 7.74%; unfilled: 2.82% ± 1.19%, 8.14% ± 6.35%; BCP1: 3.01% ± 2.57%, 8.81% ± 3.86%; BCP2: 3.24% ± 1.09%, 10.27% ± 3.98%). Conclusion: BCP with a high ratio of HA presented good osteoconductive properties and space-maintaining capacity and would be beneficial for long-term preservation or when stable graft volume is essential. [ABSTRACT FROM AUTHOR]

Published
2016
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2. Bone Regeneration Potential of Biphasic Nanocalcium Phosphate with High Hydroxyapatite/Tricalcium Phosphate Ratios in Rabbit Calvarial Defects

Author

Naruporn Monmaturapoj, Pongsakorn Praserttham, Narit Leepong, Prisana Pripatnanont, and Srisurang Suttapreyasri

Subjects
Male, X-ray microtomography, Bone Regeneration, Time Factors, Bone density, Dentistry, chemistry.chemical_element, Connective tissue, 02 engineering and technology, Calcium, 010402 general chemistry, 01 natural sciences, Parietal Bone, chemistry.chemical_compound, Bone volume fraction, Random Allocation, Bone Density, Osteogenesis, medicine, Animals, Bone regeneration, Autografts, Wound Healing, Bone Transplantation, Tissue Scaffolds, business.industry, General Medicine, X-Ray Microtomography, 021001 nanoscience & nanotechnology, Phosphate, 0104 chemical sciences, Nanostructures, medicine.anatomical_structure, chemistry, Connective Tissue, Bone Substitutes, Hydroxyapatites, Rabbits, Oral Surgery, 0210 nano-technology, business, Nuclear medicine, Parietal bone
Abstract

Purpose: This study aimed to evaluate the effect of biphasic calcium phosphate (BCP) with high hydroxyapatite/tricalcium phosphate (HA/TCP) ratios on bone formation in rabbit calvarial defects. Materials and Methods: Sixteen New Zealand white rabbits were randomly divided into two groups, a control group and an experimental group. In each animal, bilateral circular defects (10-mm diameter) were created on the calvarium. In the control group (three rabbits per time frame), defects were grafted with autogenous bone chips in one side and left empty in the other side. In the experimental group (five rabbits per time frame), defects were grafted with BCP1 (HA:TCP, 8:2) in one side and BCP2 (HA:TCP, 9:1) in the contralateral side. The animals were sacrificed at 2 and 8 weeks as designated. Bone formation and residual grafting material were assessed by radiographic densitometry, microcomputed tomography (micro-CT), and histomorphometric analysis. Results: Histologic observation revealed that BCP1, BCP2, and the autogenous bone group preserved good contours of the defect, while the unfilled defect group showed connective tissue healing. Micro-CT analysis at 8 weeks showed the comparable percentages of bone volume fraction (% BV/TV) of BCP1 (20.70% ± 2.76%) and BCP2 (20.72% ± 3.97%) and two times higher than that of 2 weeks (9.90% ± 0.75%, 10.57% ± 0.85%). The autogenous group had a significantly (P < .005) greater % BV/TV (34.58% ± 8.85%) than other groups. The percentage of the material volume fraction of BCP1 and BCP2 was not different. The histomorphometry demonstrated a higher increase in newly formed bone from 2 to 8 weeks in all groups, and all were comparable (autogenous: 4.30% ± 0.76%, 12.83% ± 7.74%; unfilled: 2.82% ± 1.19%, 8.14% ± 6.35%; BCP1: 3.01% ± 2.57%, 8.81% ± 3.86%; BCP2: 3.24% ± 1.09%, 10.27% ± 3.98%). Conclusion: BCP with a high ratio of HA presented good osteoconductive properties and space-maintaining capacity and would be beneficial for long-term preservation or when stable graft volume is essential.

Published
2016

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