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627 results on '"Pongracic, Jacqueline A"'

1. Association of Sputum Eosinophilia With Easily Measured Type-2 Inflammatory Biomarkers in Untreated Mild Persistent Asthma

Author

Ali-Dinar, Tarig, Baab, Kendall, Bach, Julia, Bacharier, Leonard, Bagley, Jennifer, Bartnikas, Lisa, Batalla, Jenny, Baxi, Sachin, Bime, Christian, Blake, Kathryn, Bloss, Valerie, Boomer, Jonathan, Boushey, Homer, Bracken, Nina, Bruce, Alice, Cabana, Michael, Caldwell, Wanda, Cardet, Juan Carlos, Carr, Tara, Castro, Mario, Cernadas, Manuela, Chinchilli, Vernon, Chmiel, James, Covar, Ronina, Cunningham, Amparito, Curtis, Vanessa, Daines, Cori, Daines, Michael, David, Sarah, DeClue, Huiqing Yin, DeLisa, Julie, Denlinger, Loren, Dickson, Mariela, Dilley, Meredith, DiMango, Emily, Dioneda, Brittney, Dyer, Anne-Marie, Engle, Linda, Fahy, John, Fandino, Nicolas, Fitzpatrick, Anne, Flexas, Iliana, Foster, Susan, Francisco, Dave, Gaffin, Jonathan, Gallopp, William, Gentile, Deborah, Gill, Mary, Goodwin, Jamie, Grossman, Nicole, Gyori, Elizabeth, Hastie, Annette, Hauptman, Marissa, Hixon, Jenny, Hmieleski, Bob, Holguin, Fernando, Hron, Bridget, Ilnicki, Melissa, Israel, Elliot, Jackson, Daniel, Kalhan, Ravi, Kantor, David, King, Tonya, Kolakowski, Tena, Koridek-Phillips, Kristen, Kraft, Monica, Krishnan, Jerry, LaForce, Craig, Lane, James, Lang, Jason, Lazarus, Stephen, Lemanske, Robert, Jr., Lima, John, Littlefield, Michelle, Logan, Laurie, Lopez, Silvia, Lucier, Jennifer, Lugogo, Njira, Manne, Akarsh, Mantia, Tarisa, Martinez, Fernando, Mauger, David, Mazzola, Geneline, Merchlinski, Aimee, Miller, Barbara, Misplay, Sarah, Moore, Wendy, Morgan, Wayne, Moseid, Cynthia, Moy, James, Myers, Ross, Narula, Surinder, Navin, Melissa, Nelson, Kyle, Nettles, Carrie, Norris, Tina, Norsworthy, Kelly, Norwick, Lourdes, Odewole, Mobolaji, Pak, Juno, Patterson, Brenda, Peters, Stephen, Phipatankul, Wanda, Pongracic, Jacqueline, Priefert, Janette, Prieto-Centurion, Valentin, Provencio, Natalie, Que, Loretta, Ramsey, Pamela, Rector, Brian, Robison, Rachel G., Roginski, Christopher, Rook, Shannon, Rosenberg, Sharon, Ross, Kristie, Ruybal, Joseph, Ryan, Elizabeth, Schierembergg, Doris, Schneider, Lynda, Scheuerman, Melissa, Sexton, Ann, Sheehan, William, Silva, Julian, Silver, Marlyne, Smith, Lewis, Sorkness, Christine, Sossong, Nicole, Sparatta, Alyssa, Stevens, Allen, Sundstrom, D., Szefler, Stanley, Tekely, Daniel, Trantow, Constance, Trasatt, Kathryn, Updegrave, Angela, Vasquez, Monica, Veri, Laura, Voigt, Thomas, Volonte, Brian, Wechsler, Michael, Wences, Jesus, Wenzel, Sally, White, Michael, Williamson, Lisa, Wilmoth, Cheryl, Wirth, Tiffany, Woodruff, Prescott, Wright, Lakeia, Yongue, Camille, Yu, Jessica, Zeller, Jennifer, Zimmerman, Ronald, Jr., Lazarus, Stephen C., Krishnan, Jerry A., Blake, Kathryn V., Sorkness, Christine A., Lang, Jason E., Lugogo, Njira L., Mauger, David T., Wechsler, Michael E., Wenzel, Sally E., Phipatanakul, Wanda, and King, Tonya S.

Published
2024
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2. Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma

Author

Ortega, Victor E, Daya, Michelle, Szefler, Stanley J, Bleecker, Eugene R, Chinchilli, Vernon M, Phipatanakul, Wanda, Mauger, Dave, Martinez, Fernando D, Herrera-Luis, Esther, Pino-Yanes, Maria, Hawkins, Gregory A, Ampleford, Elizabeth J, Kunselman, Susan J, Cox, Corey, Bacharier, Leonard B, Cabana, Michael D, Cardet, Juan Carlos, Castro, Mario, Denlinger, Loren C, Eng, Celeste, Fitzpatrick, Anne M, Holguin, Fernando, Hu, Donglei, Jackson, Daniel J, Jarjour, Nizar, Kraft, Monica, Krishnan, Jerry A, Lazarus, Stephen C, Lemanske, Robert F, Lima, John J, Lugogo, Njira, Mak, Angel, Moore, Wendy C, Naureckas, Edward T, Peters, Stephen P, Pongracic, Jacqueline A, Sajuthi, Satria P, Seibold, Max A, Smith, Lewis J, Solway, Julian, Sorkness, Christine A, Wenzel, Sally, White, Steven R, Burchard, Esteban G, Barnes, Kathleen, Meyers, Deborah A, Israel, Elliot, Wechsler, Michael E, AsthmaNet, NHLBI, Ali-Dinar, Tarig, Bartnikas, Lisa, Baxi, Sachin, Beigelman, Avraham, Benson, Mindy, Blake, Kathryn V, Burke-Roberts, Elizabeth, Cernadas, Manuela, Chmiel, James F, Covar, Ronina, DiMango, Emily, Gaffin, Jonathan, Gentile, Deborah, Grossman, Nicole, Hautpman, Marissa, Kantor, David, Kumar, Harsha, LaForce, Craig F, Lang, Jason, Long, Dayna, Louisias, Margee, Morgan, Wayne, Moy, James, Myers, Ross E, Olin, J Tod, Permaul, Perdita, Que, Loretta, Raissy, Hengameh, Robison, Rachel G, Ross, Kristie, Sheehan, William, Sullivan-Vedder, Lisa, and Wright, Lakeia

Subjects
Human Genome, Pediatric, Genetics, Lung, Clinical Research, Clinical Trials and Supportive Activities, Asthma, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Respiratory, Administration, Inhalation, Adolescent, Adrenal Cortex Hormones, Adult, Black People, Bronchodilator Agents, Child, Drug Therapy, Combination, Female, Fluticasone, Humans, Male, Middle Aged, Pharmacogenomic Testing, Salmeterol Xinafoate, United States, Young Adult, NHLBI AsthmaNet
Abstract

BackgroundPharmacogenetic studies in asthma cohorts, primarily made up of White people of European descent, have identified loci associated with response to inhaled beta agonists and corticosteroids (ICSs). Differences exist in how individuals from different ancestral backgrounds respond to long-acting beta agonist (LABA) and ICSs. Therefore, we sought to understand the pharmacogenetic mechanisms regulating therapeutic responsiveness in individuals of African descent.MethodsWe did ancestry-based pharmacogenetic studies of children (aged 5-11 years) and adolescents and adults (aged 12-69 years) from the Best African Response to Drug (BARD) trials, in which participants with asthma uncontrolled with low-dose ICS (fluticasone propionate 50 μg in children, 100 μg in adolescents and adults) received different step-up combination therapies. The hierarchal composite outcome of pairwise superior responsiveness in BARD was based on asthma exacerbations, a 31-day difference in annualised asthma-control days, or a 5% difference in percentage predicted FEV1. We did whole-genome admixture mapping of 15 159 ancestral segments within 312 independent regions, stratified by the two age groups. The two co-primary outcome comparisons were the step up from low-dose ICS to the quintuple dose of ICS (5 × ICS: 250 μg twice daily in children and 500 μg twice daily in adolescents and adults) versus double dose (2-2·5 × ICS: 100 μg twice daily in children, 250 μg twice daily in adolescents and adults), and 5 × ICS versus 100 μg fluticasone plus a LABA (salmeterol 50 μg twice daily). We used a genome-wide significance threshold of p

Published
2021

4. Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation

Author

Fitzpatrick, Anne M, Bacharier, Leonard B, Guilbert, Theresa W, Jackson, Daniel J, Szefler, Stanley J, Beigelman, Avraham, Cabana, Michael D, Covar, Ronina, Holguin, Fernando, Lemanske, Robert F, Martinez, Fernando D, Morgan, Wayne, Phipatanakul, Wanda, Pongracic, Jacqueline A, Zeiger, Robert S, Mauger, David T, AsthmaNet, NIH NHLBI, Baxi, Sachin, Benson, Mindy, Blake, Kathryn, Boehmer, Susan, Burnham, Carey-Ann, Cabana, Michael, Castro, Mario, Chmiel, James, Daines, Cori, Daines, Michael, Fitzpatrick, Anne, Gaffin, Jonathan, Gentile, Deborah Ann, Gower, W Adam, Guilbert, Theresa, Israel, Elliot, Jackson, Daniel, Kelly, H William, Kumar, Harsha Vardhan, Lang, Jason, Lazarus, Stephen, Lima, John, Lemanske, Robert, Ly, Ngoc, Martinez, Fernando, Marbin, Jyothi, Mauger, David, Meade, Kelley, Moy, James, Myers, Ross, Olin, Tod, Paul, Ian, Peters, Stephen, Pongracic, Jacqueline, Raissy, Hengameh, Robison, Rachel, Ross, Kristie, Sorkness, Christine, Sheehan, William, Szefler, Stanley, Teague, W Gerald, and Thyne, Shannon

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Asthma, Lung, Clinical Trials and Supportive Activities, Prevention, Infectious Diseases, Clinical Research, Respiratory, Adrenal Cortex Hormones, Child, Preschool, Cross-Over Studies, Disease Progression, Female, Humans, Hypersensitivity, Infant, Latent Class Analysis, Male, Phenotype, Respiratory Sounds, Asthma in children, Asthma exacerbation, Wheeze, Preschool child, Inhaled corticosteroid, Sensitization, Latent class analysis, Type 2 inflammation, NIH/NHLBI AsthmaNet, Immunology
Abstract

BackgroundRecurrent preschool wheezing is a heterogeneous disorder with significant morbidity, yet little is known about phenotypic determinants and their impact on clinical outcomes.ObjectiveLatent class analysis (LCA) was used to identify latent classes of recurrent preschool wheeze and their association with future exacerbations and inhaled corticosteroid (ICS) treatment response.MethodsData from 5 clinical trials of 1708 children aged 12 to 71 months with recurrent wheezing were merged. LCA was performed on 10 demographic, exposure, and sensitization variables to determine the optimal number of latent classes. The primary outcome was the annualized rate of wheezing exacerbations requiring systemic corticosteroids during the study intervention period; the secondary outcome was the time to first exacerbation. Exploratory analyses examined the effect of daily ICS treatment on exacerbation outcomes.ResultsFour latent classes of recurrent wheezing were identified; these were not distinguished by current symptoms or historical exacerbations but differed with regard to allergen sensitization and/or exposures. Annualized exacerbation rates (mean ± SEM/year) were 0.65 ± 0.06 for class 1 ("minimal sensitization"), 0.93 ± 0.10 for class 2 ("sensitization with indoor pet exposure"), 0.60 ± 0.07 for class 3 ("sensitization with tobacco smoke exposure"), and 0.81 ± 0.10 for class 4 ("multiple sensitization and eczema") (P < .001). In a research setting of high adherence, daily ICS treatment improved exacerbation rates in classes 2 and 4 but not the other groups.ConclusionsSensitization and exposure assessments are useful in the prediction of future exacerbation and may identify children most likely to respond favorably to daily ICS treatment.

Published
2019

5. Associations between outdoor air pollutants and non-viral asthma exacerbations and airway inflammatory responses in children and adolescents living in urban areas in the USA: a retrospective secondary analysis

Author

Altman, Matthew C, Kattan, Meyer, O'Connor, George T, Murphy, Ryan C, Whalen, Elizabeth, LeBeau, Petra, Calatroni, Agustin, Gill, Michelle A, Gruchalla, Rebecca S, Liu, Andrew H, Lovinsky-Desir, Stephanie, Pongracic, Jacqueline A, Kercsmar, Carolyn M, Khurana Hershey, Gurjit K, Zoratti, Edward M, Teach, Stephen J, Bacharier, Leonard B, Wheatley, Lisa M, Sigelman, Steve M, Gergen, Peter J, Togias, Alkis, Busse, William W, Gern, James E, and Jackson, Daniel J

Published
2023
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6. Distinct nasal airway bacterial microbiotas differentially relate to exacerbation in pediatric patients with asthma

Author

McCauley, Kathryn, Durack, Juliana, Valladares, Ricardo, Fadrosh, Douglas W, Lin, Din L, Calatroni, Agustin, LeBeau, Petra K, Tran, Hoang T, Fujimura, Kei E, LaMere, Brandon, Merana, Geil, Lynch, Kole, Cohen, Robyn T, Pongracic, Jacqueline, Hershey, Gurjit K Khurana, Kercsmar, Carolyn M, Gill, Michelle, Liu, Andrew H, Kim, Haejin, Kattan, Meyer, Teach, Stephen J, Togias, Alkis, Boushey, Homer A, Gern, James E, Jackson, Daniel J, Lynch, Susan V, and Consortium, Institute of Allergy and Infectious Diseases–sponsored Inner-City Asthma

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Asthma, Clinical Research, Pediatric, Infectious Diseases, 2.1 Biological and endogenous factors, Aetiology, 2.2 Factors relating to the physical environment, Infection, Respiratory, A549 Cells, Adolescent, Cell Death, Child, Disease Progression, Eosinophils, Female, Humans, Infant, Inflammation, Male, Microbiota, Nasal Mucosa, RNA, Ribosomal, 16S, Respiratory System, Respiratory Tract Infections, Moraxella species, Staphylococcus species, 16S rRNA, airway, asthma, exacerbation, rhinovirus, National Institute of Allergy and Infectious Diseases–sponsored Inner-City Asthma Consortium, Immunology, Allergy
Abstract

BackgroundIn infants, distinct nasopharyngeal bacterial microbiotas differentially associate with the incidence and severity of acute respiratory tract infection and childhood asthma development.ObjectiveWe hypothesized that distinct nasal airway microbiota structures also exist in children with asthma and relate to clinical outcomes.MethodsNasal secretion samples (n = 3122) collected after randomization during the fall season from children with asthma (6-17 years, n = 413) enrolled in a trial of omalizumab (anti-IgE) underwent 16S rRNA profiling. Statistical analyses with exacerbation as the primary outcome and rhinovirus infection and respiratory illnesses as secondary outcomes were performed. Using A549 epithelial cells, we assessed nasal isolates of Moraxella, Staphylococcus, and Corynebacterium species for their capacity to induce epithelial damage and inflammatory responses.ResultsSix nasal airway microbiota assemblages, each dominated by Moraxella, Staphylococcus, Corynebacterium, Streptococcus, Alloiococcus, or Haemophilus species, were observed. Moraxella and Staphylococcus species-dominated microbiotas were most frequently detected and exhibited temporal stability. Nasal microbiotas dominated by Moraxella species were associated with increased exacerbation risk and eosinophil activation. Staphylococcus or Corynebacterium species-dominated microbiotas were associated with reduced respiratory illness and exacerbation events, whereas Streptococcus species-dominated assemblages increased the risk of rhinovirus infection. Nasal microbiota composition remained relatively stable despite viral infection or exacerbation; only a few taxa belonging to the dominant genera exhibited relative abundance fluctuations during these events. In vitro, Moraxella catarrhalis induced significantly greater epithelial damage and inflammatory cytokine expression (IL-33 and IL-8) compared with other dominant nasal bacterial isolates tested.ConclusionDistinct nasal airway microbiotas of children with asthma relate to the likelihood of exacerbation, rhinovirus infection, and respiratory illnesses during the fall season.

Published
2019

7. Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma

Author

Wechsler, Michael E, Szefler, Stanley J, Ortega, Victor E, Pongracic, Jacqueline A, Chinchilli, Vernon, Lima, John J, Krishnan, Jerry A, Kunselman, Susan J, Mauger, David, Bleecker, Eugene R, Bacharier, Leonard B, Beigelman, Avraham, Benson, Mindy, Blake, Kathryn V, Cabana, Michael D, Cardet, Juan-Carlos, Castro, Mario, Chmiel, James F, Covar, Ronina, Denlinger, Loren, DiMango, Emily, Fitzpatrick, Anne M, Gentile, Deborah, Grossman, Nicole, Holguin, Fernando, Jackson, Daniel J, Kumar, Harsha, Kraft, Monica, LaForce, Craig F, Lang, Jason, Lazarus, Stephen C, Lemanske, Robert F, Long, Dayna, Lugogo, Njira, Martinez, Fernando, Meyers, Deborah A, Moore, Wendy C, Moy, James, Naureckas, Edward, Olin, J Tod, Peters, Stephen P, Phipatanakul, Wanda, Que, Loretta, Raissy, Hengameh, Robison, Rachel G, Ross, Kristie, Sheehan, William, Smith, Lewis J, Solway, Julian, Sorkness, Christine A, Sullivan-Vedder, Lisa, Wenzel, Sally, White, Steven, and Israel, Elliot

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pediatric, Clinical Research, Lung, Asthma, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Respiratory, Administration, Inhalation, Adolescent, Adrenergic beta-2 Receptor Agonists, Adult, Black or African American, Bronchodilator Agents, Child, Child, Preschool, Cross-Over Studies, Dose-Response Relationship, Drug, Double-Blind Method, Drug Combinations, Female, Fluticasone, Glucocorticoids, Humans, Male, Prospective Studies, Salmeterol Xinafoate, NHLBI AsthmaNet, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundMorbidity from asthma is disproportionately higher among black patients than among white patients, and black patients constitute the minority of participants in trials informing treatment. Data indicate that patients with inadequately controlled asthma benefit more from addition of a long-acting beta-agonist (LABA) than from increased glucocorticoids; however, these data may not be informative for treatment in black patients.MethodsWe conducted two prospective, randomized, double-blind trials: one involving children and the other involving adolescents and adults. In both trials, the patients had at least one grandparent who identified as black and had asthma that was inadequately controlled with low-dose inhaled glucocorticoids. We compared combinations of therapy, which included the addition of a LABA (salmeterol) to an inhaled glucocorticoid (fluticasone propionate), a step-up to double to quintuple the dose of fluticasone, or both. The treatments were compared with the use of a composite measure that evaluated asthma exacerbations, asthma-control days, and lung function; data were stratified according to genotypic African ancestry.ResultsWhen quintupling the dose of fluticasone (to 250 μg twice a day) was compared with adding salmeterol (50 μg twice a day) and doubling the fluticasone (to 100 μg twice a day), a superior response occurred in 46% of the children with quintupling the fluticasone and in 46% of the children with doubling the fluticasone and adding salmeterol (P = 0.99). In contrast, more adolescents and adults had a superior response to added salmeterol than to an increase in fluticasone (salmeterol-low-dose fluticasone vs. medium-dose fluticasone, 49% vs. 28% [P = 0.003]; salmeterol-medium-dose fluticasone vs. high-dose fluticasone, 49% vs. 31% [P = 0.02]). Neither the degree of African ancestry nor baseline biomarkers predicted a superior response to specific treatments. The increased dose of inhaled glucocorticoids was associated with a decrease in the ratio of urinary cortisol to creatinine in children younger than 8 years of age.ConclusionsIn contrast to black adolescents and adults, almost half the black children with poorly controlled asthma had a superior response to an increase in the dose of an inhaled glucocorticoid and almost half had a superior response to the addition of a LABA. (Funded by the National Heart, Lung, and Blood Institute; BARD ClinicalTrials.gov number, NCT01967173.).

Published
2019

8. Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level

Author

Lazarus, Stephen C, Krishnan, Jerry A, King, Tonya S, Lang, Jason E, Blake, Kathryn V, Covar, Ronina, Lugogo, Njira, Wenzel, Sally, Chinchilli, Vernon M, Mauger, David T, Dyer, Anne-Marie, Boushey, Homer A, Fahy, John V, Woodruff, Prescott G, Bacharier, Leonard B, Cabana, Michael D, Cardet, Juan C, Castro, Mario, Chmiel, James, Denlinger, Loren, DiMango, Emily, Fitzpatrick, Anne M, Gentile, Deborah, Hastie, Annette, Holguin, Fernando, Israel, Elliot, Jackson, Daniel, Kraft, Monica, LaForce, Craig, Lemanske, Robert F, Martinez, Fernando D, Moore, Wendy, Morgan, Wayne J, Moy, James N, Myers, Ross, Peters, Stephen P, Phipatanakul, Wanda, Pongracic, Jacqueline A, Que, Loretta, Ross, Kristie, Smith, Lewis, Szefler, Stanley J, Wechsler, Michael E, and Sorkness, Christine A

Subjects
Lung, Clinical Research, Clinical Trials and Supportive Activities, Asthma, 6.1 Pharmaceuticals, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Evaluation of treatments and therapeutic interventions, Respiratory, Administration, Inhalation, Adolescent, Adult, Bronchodilator Agents, Cross-Over Studies, Double-Blind Method, Eosinophils, Female, Glucocorticoids, Humans, Leukocyte Count, Male, Medication Adherence, Middle Aged, Mometasone Furoate, Sputum, Tiotropium Bromide, Young Adult, National Heart, Lung, and Blood Institute AsthmaNet, Medical and Health Sciences, General & Internal Medicine
Abstract

BACKGROUND:In many patients with mild, persistent asthma, the percentage of eosinophils in sputum is less than 2% (low eosinophil level). The appropriate treatment for these patients is unknown. METHODS:In this 42-week, double-blind, crossover trial, we assigned 295 patients who were at least 12 years of age and who had mild, persistent asthma to receive mometasone (an inhaled glucocorticoid), tiotropium (a long-acting muscarinic antagonist), or placebo. The patients were categorized according to the sputum eosinophil level (

Published
2019

9. Challenges in assessing the efficacy of systemic corticosteroids for severe wheezing episodes in preschool children

Author

Guilbert, Theresa W, Bacharier, Leonard B, Mauger, David T, Phipatanakul, Wanda, Szefler, Stanley J, Boehmer, Susan, Beigelman, Avraham, Fitzpatrick, Anne M, Jackson, Daniel J, Baxi, Sachin N, Benson, Mindy, Burnham, Carey-Ann D, Cabana, Michael D, Castro, Mario, Chmiel, James F, Covar, Ronina, Daines, Michael, Gaffin, Jonathan M, Gentile, Deborah A, Holguin, Fernando, Israel, Elliot, Kelly, H William, Lazarus, Stephen C, Lemanske, Robert F, Ly, Ngoc, Meade, Kelley, Morgan, Wayne, Moy, James, Olin, J Tod, Peters, Stephen P, Pongracic, Jacqueline A, Raissy, Hengameh H, Ross, Kristie, Sheehan, William J, Sorkness, Christine, Teague, W Gerald, Thyne, Shannon, Martinez, Fernando D, Bartnikas, Lisa, Bouzaher, Alisha, Burke, Christopher, Cavanaugh, Matthew, Chen, Julia, Cunningham, Elizabeth, Cunningham, Amparito, Friedlander, James, Hindi, Enal, Kantor, David, Permaul, Perdita, Rao, Devako, Rossi, Melinda, Schierembergg, Doris, Schneider, Kynda, Troung, Jennifer, Umetsu, Dale, Zhou, Joseph, Chmielewski, Jill, Fishbein, Anna, Flexas, Iliana, Fuleihan, Ramsay, Kumar, Rajesh, Lane, James, Makhija, Melanie, Martos, Louis, Parker, Brandon, Prince, Benjamin, Qamar, Nashmia, Riordan, Mary, Robinson, Rachel, Samady, Waheeda, Szychlinski, Christine, Tsang, Daniel, Codispoti, Christopher, Fu, Juan, Li, Grace, Munoz-Mendoza, Diana, Thompson, Benjamin, Gleason, Melanie, Graves, Sakari, Malka, Jonathan, Phillips, Melanie, Spears, Gayle, Sundstrom, D, White, Michael, Batson, Christina, Davies, Lea, Kelly, Franceska, Morales, Esmeralda, Redway, Abby, Spicher, Mary, Kaminski, Lauren, Knutson, Megan R, Miller, Kelly, Promer, Jennifer, Turcsanyi, Sheila, Watson, Tanya, Aujla, Shean, Broyles, John, Chong, Hey, and Dubin, Patricia

Subjects
Biomedical and Clinical Sciences, Immunology, Administration, Inhalation, Adrenal Cortex Hormones, Asthma, Child, Preschool, Humans, Respiratory Sounds, National Heart, Lung, and Blood Institute's AsthmaNet, Allergy
Abstract

This letter addresses the controversial issue of the use of oral corticosteroids during wheezing exacerbations in preschool-aged children by demonstrating findings of a prematurely terminated multi-center clinical trial, discussing lessons learned, and suggesting future directions.

Published
2019

10. Mepolizumab for urban children with exacerbation-prone eosinophilic asthma in the USA (MUPPITS-2): a randomised, double-blind, placebo-controlled, parallel-group trial

Author

Jackson, Daniel J, Bacharier, Leonard B, Gergen, Peter J, Gagalis, Lisa, Calatroni, Agustin, Wellford, Stephanie, Gill, Michelle A, Stokes, Jeffrey, Liu, Andrew H, Gruchalla, Rebecca S, Cohen, Robyn T, Makhija, Melanie, Khurana Hershey, Gurjit K, O'Connor, George T, Pongracic, Jacqueline A, Sherenian, Michael G, Rivera-Spoljaric, Katherine, Zoratti, Edward M, Teach, Stephen J, Kattan, Meyer, Dutmer, Cullen M, Kim, Haejin, Lamm, Carin, Sheehan, William J, Segnitz, R Max, Dill-McFarland, Kimberly A, Visness, Cynthia M, Becker, Patrice M, Gern, James E, Sorkness, Christine A, Busse, William W, and Altman, Matthew C

Published
2022
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11. Safety of Epicutaneous Immunotherapy in Peanut-Allergic Children: REALISE Randomized Clinical Trial Results

Author

Pongracic, Jacqueline A., Gagnon, Rémi, Sussman, Gordon, Siri, Dareen, Oriel, Roxanne C., Brown-Whitehorn, Terri F., Green, Todd D., Campbell, Dianne E., Anvari, Sara, Berger, William E., Bird, J. Andrew, Chan, Edmond S., Cheema, Amarjit, Chinthrajah, R. Sharon, Chong, Hey Jin, Dowling, Paul J., Fineman, Stanley M., Fleischer, David M., Gonzalez-Reyes, Erika, Kim, Edwin H., Lanser, Bruce J., MacGinnitie, Andrew, Mehta, Hemalini, Petroni, Daniel, Rupp, Ned, Schneider, Lynda C., Scurlock, Amy M., Sher, Lawrence D., Shreffler, Wayne G., Sindher, Sayantani B., Stillerman, Allan, Wood, Robert, Yang, William H., Bois, Timothée, Sampson, Hugh A., and Bégin, Philippe

Published
2022
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12. Associations of Food Allergy-Related Dietary Knowledge, Attitudes, and Behaviors Among Caregivers of Black and White Children With Food Allergy

Author

Vincent, Eileen, Bilaver, Lucy A., Fierstein, Jamie L., Thivalapill, Neil, Pappalardo, Andrea A., Coleman, Amaziah, Robinson, Adam, Sharma, Hemant P., Brewer, Audrey, Assa’ad, Amal H., Jiang, Jialing, Hultquist, Haley W., Kulkarni, Ashwin J., Choi, Johnathan, Mahdavinia, Mahboobeh, Pongracic, Jacqueline, Tobin, Mary C., Warren, Christopher, and Gupta, Ruchi S.

Published
2022
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13. Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations

Author

Jackson, Daniel J, Bacharier, Leonard B, Mauger, David T, Boehmer, Susan, Beigelman, Avraham, Chmiel, James F, Fitzpatrick, Anne M, Gaffin, Jonathan M, Morgan, Wayne J, Peters, Stephen P, Phipatanakul, Wanda, Sheehan, William J, Cabana, Michael D, Holguin, Fernando, Martinez, Fernando D, Pongracic, Jacqueline A, Baxi, Sachin N, Benson, Mindy, Blake, Kathryn, Covar, Ronina, Gentile, Deborah A, Israel, Elliot, Krishnan, Jerry A, Kumar, Harsha V, Lang, Jason E, Lazarus, Stephen C, Lima, John J, Long, Dayna, Ly, Ngoc, Marbin, Jyothi, Moy, James N, Myers, Ross E, Olin, J Tod, Raissy, Hengameh H, Robison, Rachel G, Ross, Kristie, Sorkness, Christine A, and Lemanske, Robert F

Subjects
Pediatric, Clinical Research, Lung, Asthma, Clinical Trials and Supportive Activities, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Respiratory, Administration, Inhalation, Albuterol, Anti-Asthmatic Agents, Child, Child, Preschool, Dose-Response Relationship, Drug, Double-Blind Method, Female, Fluticasone, Growth, Humans, Male, Peak Expiratory Flow Rate, National Heart, Lung, and Blood Institute AsthmaNet, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundAsthma exacerbations occur frequently despite the regular use of asthma-controller therapies, such as inhaled glucocorticoids. Clinicians commonly increase the doses of inhaled glucocorticoids at early signs of loss of asthma control. However, data on the safety and efficacy of this strategy in children are limited.MethodsWe studied 254 children, 5 to 11 years of age, who had mild-to-moderate persistent asthma and had had at least one asthma exacerbation treated with systemic glucocorticoids in the previous year. Children were treated for 48 weeks with maintenance low-dose inhaled glucocorticoids (fluticasone propionate at a dose of 44 μg per inhalation, two inhalations twice daily) and were randomly assigned to either continue the same dose (low-dose group) or use a quintupled dose (high-dose group; fluticasone at a dose of 220 μg per inhalation, two inhalations twice daily) for 7 days at the early signs of loss of asthma control ("yellow zone"). Treatment was provided in a double-blind fashion. The primary outcome was the rate of severe asthma exacerbations treated with systemic glucocorticoids.ResultsThe rate of severe asthma exacerbations treated with systemic glucocorticoids did not differ significantly between groups (0.48 exacerbations per year in the high-dose group and 0.37 exacerbations per year in the low-dose group; relative rate, 1.3; 95% confidence interval, 0.8 to 2.1; P=0.30). The time to the first exacerbation, the rate of treatment failure, symptom scores, and albuterol use during yellow-zone episodes did not differ significantly between groups. The total glucocorticoid exposure was 16% higher in the high-dose group than in the low-dose group. The difference in linear growth between the high-dose group and the low-dose group was -0.23 cm per year (P=0.06).ConclusionsIn children with mild-to-moderate persistent asthma treated with daily inhaled glucocorticoids, quintupling the dose at the early signs of loss of asthma control did not reduce the rate of severe asthma exacerbations or improve other asthma outcomes and may be associated with diminished linear growth. (Funded by the National Heart, Lung, and Blood Institute; STICS ClinicalTrials.gov number, NCT02066129 .).

Published
2018

14. Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation

Author

Bacharier, Leonard B., Baxi, Sachin, Beigelman, Avraham, Benson, Mindy, Blake, Kathryn, Boehmer, Susan, Burnham, Carey-Ann, Cabana, Michael, Castro, Mario, Chmiel, James, Covar, Ronina, Daines, Cori, Daines, Michael, Fitzpatrick, Anne, Gaffin, Jonathan, Ann Gentile, Deborah, Gower, W. Adam, Guilbert, Theresa, Holguin, Fernando, Israel, Elliot, Jackson, Daniel, Kelly, H. William, Kumar, Harsha Vardhan, Jason Lang, Lazarus, Stephen, Lima, John, Lemanske, Robert, Jr., Ly, Ngoc, Martinez, Fernando, Marbin, Jyothi, Mauger, David, Meade, Kelley, Morgan, Wayne, Moy, James, Myers, Ross, Olin, Tod, Paul, Ian, Peters, Stephen, Phipatanakul, Wanda, Pongracic, Jacqueline, Raissy, Hengameh, Robison, Rachel, Ross, Kristie, Christine Sorkness, Sheehan, William, Szefler, Stanley, Teague, W. Gerald, Thyne, Shannon, Fitzpatrick, Anne M., Guilbert, Theresa W., Jackson, Daniel J., Szefler, Stanley J., Cabana, Michael D., Lemanske, Robert F., Jr., Martinez, Fernando D., Pongracic, Jacqueline A., Zeiger, Robert S., and Mauger, David T.

Published
2019
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16. African American Children Are More Likely to Be Allergic to Shellfish and Finfish: Findings from FORWARD, a Multisite Cohort Study

Author

Mahdavinia, Mahboobeh, Tobin, Mary C., Fierstein, Jamie L., Andy-Nweye, Aame B., Bilaver, Lucy A., Fox, Susan, Pappalardo, Andrea A., Jiang, Jialing, Catlin, Perry A., Chura, Annika, Robinson, Adam, Abdikarim, Iman, Coleman, Amaziah, Warren, Christopher M., Newmark, Pamela J., Bozen, Alexandria, Negris, Olivia R., Pongracic, Jacqueline A., Sharma, Hemant P., Assa'ad, Amal H., and Gupta, Ruchi S.

Published
2021
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18. Continuous and Daily Oral Immunotherapy for Peanut Allergy: Results from a 2-Year Open-Label Follow-On Study

Author

Vickery, Brian P., Vereda, Andrea, Nilsson, Caroline, du Toit, George, Shreffler, Wayne G., Burks, A. Wesley, Jones, Stacie M., Fernández-Rivas, Montserrat, Blümchen, Katharina, O’B. Hourihane, Jonathan, Beyer, Kirsten, Anagnostou, Aikaterini, Assa’ad, Amal H., Ben-Shoshan, Moshe, Bird, J. Andrew, Carr, Tara F., Carr, Warner W., Casale, Thomas B., Chong, Hey Jin, Ciaccio, Christina E., Dorsey, Morna J., Fineman, Stanley M., Fritz, Stephen B., Greiner, Alexander N., Greos, Leon S., Hampel, Frank C., Jr., Ibáñez, Maria Dolores, Jeong, David K., Johnston, Douglas T., Kachru, Rita, Kim, Edwin H., Lanser, Bruce J., Leonard, Stephanie A., Maier, Mary C., Mansfield, Lyndon E., Muraro, Antonella, Ohayon, Jason A., Oude Elberink, Joanna N.G., Petroni, Daniel H., Pongracic, Jacqueline A., Portnoy, Jay M., Rachid, Rima, Rupp, Ned T., Sanders, Georgiana M., Sharma, Hemant P., Sharma, Vibha, Sher, Ellen R., Sher, Lawrence, Sindher, Sayantani B., Siri, Dareen, Spergel, Jonathan M., Sprikkelman, Aline B., Sussman, Gordon L., Tsoumani, Marina, Varshney, Pooja, Vitalpur, Girish, Wang, Julie, Yang, William H., Zubeldia, José Manuel, Smith, Alex, Ryan, Robert, and Adelman, Daniel C.

Published
2021
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19. Food allergy-related bullying and associated peer dynamics among Black and White children in the FORWARD study

Author

Brown, Dannielle, Negris, Olivia, Gupta, Ruchi, Herbert, Linda, Lombard, Lisa, Bozen, Alexandria, Assa'ad, Amal, Chura, Annika, Andy-Nweye, Aame B., Fox, Susan, Mahdavinia, Mahboobeh, Tobin, Mary, Robinson, Adam, Sharma, Hemant, Coleman, Amaziah, Jiang, Jialing, Bilaver, Lucy, Fierstein, Jamie L., Galic, Isabel, Newmark, Pamela, Pongracic, Jacqueline A., Pappalardo, Andrea A., and Warren, Christopher

Published
2021
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20. Individualized therapy for persistent asthma in young children.

Author

Fitzpatrick, Anne M, Jackson, Daniel J, Mauger, David T, Boehmer, Susan J, Phipatanakul, Wanda, Sheehan, William J, Moy, James N, Paul, Ian M, Bacharier, Leonard B, Cabana, Michael D, Covar, Ronina, Holguin, Fernando, Lemanske, Robert F, Martinez, Fernando D, Pongracic, Jacqueline A, Beigelman, Avraham, Baxi, Sachin N, Benson, Mindy, Blake, Kathryn, Chmiel, James F, Daines, Cori L, Daines, Michael O, Gaffin, Jonathan M, Gentile, Deborah Ann, Gower, W Adam, Israel, Elliot, Kumar, Harsha Vardhan, Lang, Jason E, Lazarus, Stephen C, Lima, John J, Ly, Ngoc, Marbin, Jyothi, Morgan, Wayne, Myers, Ross E, Olin, J Tod, Peters, Stephen P, Raissy, Hengameh H, Robison, Rachel G, Ross, Kristie, Sorkness, Christine A, Thyne, Shannon M, Szefler, Stanley J, and NIH/NHLBI AsthmaNet

Subjects
NIH/NHLBI AsthmaNet, Humans, Asthma, Recurrence, Albuterol, Leukotriene Antagonists, Adrenal Cortex Hormones, Treatment Outcome, Administration, Inhalation, Follow-Up Studies, Child, Preschool, Infant, United States, Female, Male, Precision Medicine, asthma biomarkers, asthma phenotype, asthma treatment, inhaled corticosteroid, leukotriene receptor antagonist, personalized medicine, treatment response, Lung, Clinical Trials and Supportive Activities, Pediatric, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Respiratory, Good Health and Well Being, Immunology, Allergy
Abstract

BackgroundPhenotypic presentations in young children with asthma are varied and might contribute to differential responses to asthma controller medications.MethodsThe Individualized Therapy for Asthma in Toddlers study was a multicenter, randomized, double-blind, double-dummy clinical trial in children aged 12 to 59 months (n = 300) with asthma necessitating treatment with daily controller (Step 2) therapy. Participants completed a 2- to 8-week run-in period followed by 3 crossover periods with daily inhaled corticosteroids (ICSs), daily leukotriene receptor antagonists, and as-needed ICS treatment coadministered with albuterol. The primary outcome was differential response to asthma medication based on a composite measure of asthma control. The primary analysis involved 2 stages: determination of differential response and assessment of whether 3 prespecified features (aeroallergen sensitization, previous exacerbations, and sex) predicted a differential response.ResultsSeventy-four percent (170/230) of children with analyzable data had a differential response to the 3 treatment strategies. Within differential responders, the probability of best response was highest for a daily ICS and was predicted by aeroallergen sensitization but not exacerbation history or sex. The probability of best response to daily ICS was further increased in children with both aeroallergen sensitization and blood eosinophil counts of 300/μL or greater. In these children daily ICS use was associated with more asthma control days and fewer exacerbations compared with the other treatments.ConclusionsIn young children with asthma necessitating Step 2 treatment, phenotyping with aeroallergen sensitization and blood eosinophil counts is useful for guiding treatment selection and identifies children with a high exacerbation probability for whom treatment with a daily ICS is beneficial despite possible risks of growth suppression.

Published
2016

22. Heterogeneity of Mild to Moderate Persistent Asthma in Children: Confirmation by Latent Class Analysis and Association with 1-Year Outcomes

Author

Fitzpatrick, Anne M., Bacharier, Leonard B., Jackson, Daniel J., Szefler, Stanley J., Beigelman, Avraham, Cabana, Michael, Covar, Ronina, Guilbert, Theresa, Holguin, Fernando, Lemanske, Robert F., Martinez, Fernando D., Morgan, Wayne, Phipatanakul, Wanda, Pongracic, Jacqueline A., Raissy, Hengameh H., Zeiger, Robert S., and Mauger, David T.

Published
2020
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24. Airway and Systemic Dysregulation of Interferon Responses Promote Asthma Exacerbations in Urban Children

Author

Gaberino, Courtney, primary, Altman, Matthew, additional, Gill, Michelle, additional, Bacharier, Leonard, additional, Gruchalla, Rebecca, additional, O'Connor, George, additional, Pongracic, Jacqueline, additional, Hershey, Gurjit Khurana, additional, Kattan, Meyer, additional, Liu, Andrew, additional, Teach, Stephen, additional, Zoratti, Edward, additional, Gergen, Peter, additional, Visness, Cindy, additional, Busse, William, additional, and Jackson, Daniel, additional

Published
2024
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25. Rhinovirus circulation patterns and age predilection of infection in children from 1997-2018

Author

Gao, YingYu, primary, Choi, Timothy, additional, Devries, Mark, additional, Tetreault, Kaitlin, additional, Gangnon, Ronald, additional, Bacharier, Leonard, additional, Busse, William, additional, Camargo, Carlos, additional, Cohen, Robyn, additional, DeMuri, Gregory, additional, Fitzpatrick, Anne, additional, Gergen, Peter, additional, Grindle, Kristine, additional, Gruchalla, Rebecca, additional, Hartert, Tina, additional, Hasegawa, Kohei, additional, Hershey, Gurjit Khurana, additional, Holt, Patrick, additional, Homil, Kiara, additional, Jartti, Tuomas, additional, Kattan, Meyer, additional, Kercsmar, Carolyn, additional, Kim, Haejin, additional, Laing, Ingrid, additional, Le Souef, Peter, additional, Liu, Andrew, additional, Mauger, David, additional, Pappas, Tressa, additional, Patel, Shilpa, additional, Phipatanakul, Wanda, additional, Pongracic, Jacqueline, additional, Seroogy, Christine, additional, Sly, Peter, additional, Tisler, Christopher, additional, Wald, Ellen, additional, Wood, Robert, additional, Lemanske, Robert, additional, Jackson, Daniel, additional, Bochkov, Yury, additional, Gern, James, additional, and Wilson, Jo, additional

Published
2024
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26. Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma

Author

Sheehan, William J, Mauger, David T, Paul, Ian M, Moy, James N, Boehmer, Susan J, Szefler, Stanley J, Fitzpatrick, Anne M, Jackson, Daniel J, Bacharier, Leonard B, Cabana, Michael D, Covar, Ronina, Holguin, Fernando, Lemanske, Robert F, Martinez, Fernando D, Pongracic, Jacqueline A, Beigelman, Avraham, Baxi, Sachin N, Benson, Mindy, Blake, Kathryn, Chmiel, James F, Daines, Cori L, Daines, Michael O, Gaffin, Jonathan M, Gentile, Deborah A, Gower, W Adam, Israel, Elliot, Kumar, Harsha V, Lang, Jason E, Lazarus, Stephen C, Lima, John J, Ly, Ngoc, Marbin, Jyothi, Morgan, Wayne J, Myers, Ross E, Olin, J Tod, Peters, Stephen P, Raissy, Hengameh H, Robison, Rachel G, Ross, Kristie, Sorkness, Christine A, Thyne, Shannon M, Wechsler, Michael E, and Phipatanakul, Wanda

Subjects
Pediatric, Clinical Research, Lung, Asthma, Clinical Trials and Supportive Activities, Respiratory, Acetaminophen, Child, Preschool, Double-Blind Method, Female, Fever, Humans, Ibuprofen, Incidence, Infant, Kaplan-Meier Estimate, Male, Pain, Prospective Studies, NIH/NHLBI AsthmaNet, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundStudies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking.MethodsIn a multicenter, prospective, randomized, double-blind, parallel-group trial, we enrolled 300 children (age range, 12 to 59 months) with mild persistent asthma and assigned them to receive either acetaminophen or ibuprofen when needed for the alleviation of fever or pain over the course of 48 weeks. The primary outcome was the number of asthma exacerbations that led to treatment with systemic glucocorticoids. Children in both groups received standardized asthma-controller therapies that were used in a simultaneous, factorially linked trial.ResultsParticipants received a median of 5.5 doses (interquartile range, 1.0 to 15.0) of trial medication; there was no significant between-group difference in the median number of doses received (P=0.47). The number of asthma exacerbations did not differ significantly between the two groups, with a mean of 0.81 per participant with acetaminophen and 0.87 per participant with ibuprofen over 46 weeks of follow-up (relative rate of asthma exacerbations in the acetaminophen group vs. the ibuprofen group, 0.94; 95% confidence interval, 0.69 to 1.28; P=0.67). In the acetaminophen group, 49% of participants had at least one asthma exacerbation and 21% had at least two, as compared with 47% and 24%, respectively, in the ibuprofen group. Similarly, no significant differences were detected between acetaminophen and ibuprofen with respect to the percentage of asthma-control days (85.8% and 86.8%, respectively; P=0.50), use of an albuterol rescue inhaler (2.8 and 3.0 inhalations per week, respectively; P=0.69), unscheduled health care utilization for asthma (0.75 and 0.76 episodes per participant, respectively; P=0.94), or adverse events.ConclusionsAmong young children with mild persistent asthma, as-needed use of acetaminophen was not shown to be associated with a higher incidence of asthma exacerbations or worse asthma control than was as-needed use of ibuprofen. (Funded by the National Institutes of Health; AVICA ClinicalTrials.gov number, NCT01606319.).

Published
2016

27. Association of Sputum Eosinophilia With Easily Measured Type-2 Inflammatory Biomarkers in Untreated Mild Persistent Asthma

Author

Covar, Ronina, primary, Lazarus, Stephen C., additional, Krishnan, Jerry A., additional, Blake, Kathryn V., additional, Sorkness, Christine A., additional, Dyer, Anne-Marie, additional, Lang, Jason E., additional, Lugogo, Njira L., additional, Mauger, David T., additional, Wechsler, Michael E., additional, Wenzel, Sally E., additional, Cardet, Juan Carlos, additional, Castro, Mario, additional, Israel, Elliot, additional, Phipatanakul, Wanda, additional, King, Tonya S., additional, Ali-Dinar, Tarig, additional, Baab, Kendall, additional, Bach, Julia, additional, Bacharier, Leonard, additional, Bagley, Jennifer, additional, Bartnikas, Lisa, additional, Batalla, Jenny, additional, Baxi, Sachin, additional, Bime, Christian, additional, Blake, Kathryn, additional, Bloss, Valerie, additional, Boomer, Jonathan, additional, Boushey, Homer, additional, Bracken, Nina, additional, Bruce, Alice, additional, Cabana, Michael, additional, Caldwell, Wanda, additional, Carr, Tara, additional, Cernadas, Manuela, additional, Chinchilli, Vernon, additional, Chmiel, James, additional, Covar, Ronina, additional, Cunningham, Amparito, additional, Curtis, Vanessa, additional, Daines, Cori, additional, Daines, Michael, additional, David, Sarah, additional, DeClue, Huiqing Yin, additional, DeLisa, Julie, additional, Denlinger, Loren, additional, Dickson, Mariela, additional, Dilley, Meredith, additional, DiMango, Emily, additional, Dioneda, Brittney, additional, Engle, Linda, additional, Fahy, John, additional, Fandino, Nicolas, additional, Fitzpatrick, Anne, additional, Flexas, Iliana, additional, Foster, Susan, additional, Francisco, Dave, additional, Gaffin, Jonathan, additional, Gallopp, William, additional, Gentile, Deborah, additional, Gill, Mary, additional, Goodwin, Jamie, additional, Grossman, Nicole, additional, Gyori, Elizabeth, additional, Hastie, Annette, additional, Hauptman, Marissa, additional, Hixon, Jenny, additional, Hmieleski, Bob, additional, Holguin, Fernando, additional, Hron, Bridget, additional, Ilnicki, Melissa, additional, Jackson, Daniel, additional, Kalhan, Ravi, additional, Kantor, David, additional, King, Tonya, additional, Kolakowski, Tena, additional, Koridek-Phillips, Kristen, additional, Kraft, Monica, additional, Krishnan, Jerry, additional, LaForce, Craig, additional, Lane, James, additional, Lang, Jason, additional, Lazarus, Stephen, additional, Lemanske, Robert, additional, Lima, John, additional, Littlefield, Michelle, additional, Logan, Laurie, additional, Lopez, Silvia, additional, Lucier, Jennifer, additional, Lugogo, Njira, additional, Manne, Akarsh, additional, Mantia, Tarisa, additional, Martinez, Fernando, additional, Mauger, David, additional, Mazzola, Geneline, additional, Merchlinski, Aimee, additional, Miller, Barbara, additional, Misplay, Sarah, additional, Moore, Wendy, additional, Morgan, Wayne, additional, Moseid, Cynthia, additional, Moy, James, additional, Myers, Ross, additional, Narula, Surinder, additional, Navin, Melissa, additional, Nelson, Kyle, additional, Nettles, Carrie, additional, Norris, Tina, additional, Norsworthy, Kelly, additional, Norwick, Lourdes, additional, Odewole, Mobolaji, additional, Pak, Juno, additional, Patterson, Brenda, additional, Peters, Stephen, additional, Phipatankul, Wanda, additional, Pongracic, Jacqueline, additional, Priefert, Janette, additional, Prieto-Centurion, Valentin, additional, Provencio, Natalie, additional, Que, Loretta, additional, Ramsey, Pamela, additional, Rector, Brian, additional, Robison, Rachel G., additional, Roginski, Christopher, additional, Rook, Shannon, additional, Rosenberg, Sharon, additional, Ross, Kristie, additional, Ruybal, Joseph, additional, Ryan, Elizabeth, additional, Schierembergg, Doris, additional, Schneider, Lynda, additional, Scheuerman, Melissa, additional, Sexton, Ann, additional, Sheehan, William, additional, Silva, Julian, additional, Silver, Marlyne, additional, Smith, Lewis, additional, Sorkness, Christine, additional, Sossong, Nicole, additional, Sparatta, Alyssa, additional, Stevens, Allen, additional, Sundstrom, D., additional, Szefler, Stanley, additional, Tekely, Daniel, additional, Trantow, Constance, additional, Trasatt, Kathryn, additional, Updegrave, Angela, additional, Vasquez, Monica, additional, Veri, Laura, additional, Voigt, Thomas, additional, Volonte, Brian, additional, Wechsler, Michael, additional, Wences, Jesus, additional, Wenzel, Sally, additional, White, Michael, additional, Williamson, Lisa, additional, Wilmoth, Cheryl, additional, Wirth, Tiffany, additional, Woodruff, Prescott, additional, Wright, Lakeia, additional, Yongue, Camille, additional, Yu, Jessica, additional, Zeller, Jennifer, additional, and Zimmerman, Ronald, additional

Published
2023
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29. Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses: A Randomized Clinical Trial.

Author

Bacharier, Leonard B, Guilbert, Theresa W, Mauger, David T, Boehmer, Susan, Beigelman, Avraham, Fitzpatrick, Anne M, Jackson, Daniel J, Baxi, Sachin N, Benson, Mindy, Burnham, Carey-Ann D, Cabana, Michael, Castro, Mario, Chmiel, James F, Covar, Ronina, Daines, Michael, Gaffin, Jonathan M, Gentile, Deborah Ann, Holguin, Fernando, Israel, Elliot, Kelly, H William, Lazarus, Stephen C, Lemanske, Robert F, Ly, Ngoc, Meade, Kelley, Morgan, Wayne, Moy, James, Olin, Tod, Peters, Stephen P, Phipatanakul, Wanda, Pongracic, Jacqueline A, Raissy, Hengameh H, Ross, Kristie, Sheehan, William J, Sorkness, Christine, Szefler, Stanley J, Teague, W Gerald, Thyne, Shannon, and Martinez, Fernando D

Subjects
Humans, Respiratory Tract Infections, Disease Progression, Recurrence, Azithromycin, Anti-Bacterial Agents, Drug Administration Schedule, Double-Blind Method, Drug Resistance, Bacterial, Child, Preschool, Infant, Female, Male, Secondary Prevention, Complementary and Integrative Health, Clinical Trials and Supportive Activities, Clinical Research, Infectious Diseases, Prevention, Lung, Pediatric, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Medical and Health Sciences, General & Internal Medicine
Abstract

ImportanceMany preschool children develop recurrent, severe episodes of lower respiratory tract illness (LRTI). Although viral infections are often present, bacteria may also contribute to illness pathogenesis. Strategies that effectively attenuate such episodes are needed.ObjectiveTo evaluate if early administration of azithromycin, started prior to the onset of severe LRTI symptoms, in preschool children with recurrent severe LRTIs can prevent the progression of these episodes.Design, setting, and participantsA randomized, double-blind, placebo-controlled, parallel-group trial conducted across 9 academic US medical centers in the National Heart, Lung, and Blood Institute's AsthmaNet network, with enrollment starting in April 2011 and follow-up complete by December 2014. Participants were 607 children aged 12 through 71 months with histories of recurrent, severe LRTIs and minimal day-to-day impairment.InterventionParticipants were randomly assigned to receive azithromycin (12 mg/kg/d for 5 days; n = 307) or matching placebo (n = 300), started early during each predefined RTI (child's signs or symptoms prior to development of LRTI), based on individualized action plans, over a 12- through 18-month period.Main outcomes and measuresThe primary outcome measure was the number of RTIs not progressing to a severe LRTI, measured at the level of the RTI, that would in clinical practice trigger the prescription of oral corticosteroids. Presence of azithromycin-resistant organisms in oropharyngeal samples, along with adverse events, were among the secondary outcome measures.ResultsA total of 937 treated RTIs (azithromycin group, 473; placebo group, 464) were experienced by 443 children (azithromycin group, 223; placebo group, 220), including 92 severe LRTIs (azithromycin group, 35; placebo group, 57). Azithromycin significantly reduced the risk of progressing to severe LRTI relative to placebo (hazard ratio, 0.64 [95% CI, 0.41-0.98], P = .04; absolute risk for first RTI: 0.05 for azithromycin, 0.08 for placebo; risk difference, 0.03 [95% CI, 0.00-0.06]). Induction of azithromycin-resistant organisms and adverse events were infrequently observed.Conclusions and relevanceAmong young children with histories of recurrent severe LRTIs, the use of azithromycin early during an apparent RTI compared with placebo reduced the likelihood of severe LRTI. More information is needed on the development of antibiotic-resistant pathogens with this strategy.Trial registrationclinicaltrials.gov Identifier: NCT01272635.

Published
2015

32. A Phase 2 Randomized Controlled Multisite Study Using Omalizumab-facilitated Rapid Desensitization to Test Continued vs Discontinued Dosing in Multifood Allergic Individuals

Author

Andorf, Sandra, Purington, Natasha, Kumar, Divya, Long, Andrew, O'Laughlin, Katherine L., Sicherer, Scott, Sampson, Hugh, Cianferoni, Antonella, Whitehorn, Terri Brown, Petroni, Daniel, Makhija, Melanie, Robison, Rachel G., Lierl, Michelle, Logsdon, Stephanie, Desai, Manisha, Galli, Stephen J., Rael, Efren, Assa'ad, Amal, Chinthrajah, Sharon, Pongracic, Jacqueline, Spergel, Jonathan M., Tam, Jonathan, Tilles, Stephen, Wang, Julie, and Nadeau, Kari

Published
2019
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33. Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children

Author

Altman, Matthew C., Gill, Michelle A., Whalen, Elizabeth, Babineau, Denise C., Shao, Baomei, Liu, Andrew H., Jepson, Brett, Gruchalla, Rebecca S., O’Connor, George T., Pongracic, Jacqueline A., Kercsmar, Carolyn M., Khurana Hershey, Gurjit K., Zoratti, Edward M., Johnson, Christine C., Teach, Stephen J., Kattan, Meyer, Bacharier, Leonard B., Beigelman, Avraham, Sigelman, Steve M., Presnell, Scott, Gern, James E., Gergen, Peter J., Wheatley, Lisa M., Togias, Alkis, Busse, William W., and Jackson, Daniel J.

Published
2019
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35. Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut Allergy

Author

Greenhawt, Matthew, primary, Sindher, Sayantani B., additional, Wang, Julie, additional, O’Sullivan, Michael, additional, du Toit, George, additional, Kim, Edwin H., additional, Albright, Deborah, additional, Anvari, Sara, additional, Arends, Nicolette, additional, Arkwright, Peter D., additional, Bégin, Philippe, additional, Blumchen, Katharina, additional, Bourrier, Thierry, additional, Brown-Whitehorn, Terri, additional, Cassell, Heather, additional, Chan, Edmond S., additional, Ciaccio, Christina E., additional, Deschildre, Antoine, additional, Divaret-Chauveau, Amandine, additional, Dorris, Stacy L., additional, Dorsey, Morna J., additional, Eiwegger, Thomas, additional, Erlewyn-Lajeunesse, Michel, additional, Fleischer, David M., additional, Ford, Lara S., additional, Garcia-Lloret, Maria, additional, Giovannini-Chami, Lisa, additional, Hourihane, Jonathan O., additional, Jay, Nicola, additional, Jones, Stacie M., additional, Kerns, Leigh Ann, additional, Kloepfer, Kirsten M., additional, Leonard, Stephanie, additional, Lezmi, Guillaume, additional, Lieberman, Jay A., additional, Lomas, Jeanne, additional, Makhija, Melanie, additional, Parrish, Christopher, additional, Peake, Jane, additional, Perrett, Kirsten P., additional, Petroni, Daniel, additional, Pfützner, Wolfgang, additional, Pongracic, Jacqueline A., additional, Quinn, Patrick, additional, Robison, Rachel G., additional, Sanders, Georgiana, additional, Schneider, Lynda, additional, Sharma, Hemant P., additional, Trujillo, Juan, additional, Turner, Paul J., additional, Tuttle, Katherine, additional, Upton, Julia E., additional, Varshney, Pooja, additional, Vickery, Brian P., additional, Vogelberg, Christian, additional, Wainstein, Brynn, additional, Wood, Robert A., additional, Bee, Katharine J., additional, Campbell, Dianne E., additional, Green, Todd D., additional, Rouissi, Rihab, additional, Peillon, Aurélie, additional, Bahnson, Henry T., additional, Bois, Timothée, additional, Sampson, Hugh A., additional, and Burks, A. Wesley, additional

Published
2023
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37. Distinguishing characteristics of difficult-to-control asthma in inner-city children and adolescents

Author

Pongracic, Jacqueline A., Krouse, Rebecca Z., Babineau, Denise C., Zoratti, Edward M., Cohen, Robyn T., Wood, Robert A., Khurana Hershey, Gurjit K., Kercsmar, Carolyn M., Gruchalla, Rebecca S., Kattan, Meyer, Teach, Stephen J., Johnson, Christine C., Bacharier, Leonard B., Gern, James E., Sigelman, Steven M., Gergen, Peter J., Togias, Alkis, Visness, Cynthia M., Busse, William W., and Liu, Andrew H.

Published
2016
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38. Pathways through which asthma risk factors contribute to asthma severity in inner-city children

Author

Liu, Andrew H., Babineau, Denise C., Krouse, Rebecca Z., Zoratti, Edward M., Pongracic, Jacqueline A., O'Connor, George T., Wood, Robert A., Khurana Hershey, Gurjit K., Kercsmar, Carolyn M., Gruchalla, Rebecca S., Kattan, Meyer, Teach, Stephen J., Makhija, Melanie, Pillai, Dinesh, Lamm, Carin I., Gern, James E., Sigelman, Steven M., Gergen, Peter J., Togias, Alkis, Visness, Cynthia M., and Busse, William W.

Published
2016
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39. Asthma phenotypes in inner-city children

Author

Zoratti, Edward M., Krouse, Rebecca Z., Babineau, Denise C., Pongracic, Jacqueline A., O'Connor, George T., Wood, Robert A., Khurana Hershey, Gurjit K., Kercsmar, Carolyn M., Gruchalla, Rebecca S., Kattan, Meyer, Teach, Stephen J., Sigelman, Steven M., Gergen, Peter J., Togias, Alkis, Visness, Cynthia M., Busse, William W., and Liu, Andrew H.

Published
2016
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41. Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations

Author

Teach, Stephen J., Gill, Michelle A., Togias, Alkis, Sorkness, Christine A., Arbes, Samuel J., Jr., Calatroni, Agustin, Wildfire, Jeremy J., Gergen, Peter J., Cohen, Robyn T., Pongracic, Jacqueline A., Kercsmar, Carolyn M., Khurana Hershey, Gurjit K., Gruchalla, Rebecca S., Liu, Andrew H., Zoratti, Edward M., Kattan, Meyer, Grindle, Kristine A., Gern, James E., Busse, William W., and Szefler, Stanley J.

Published
2015
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42. Down-Modulation of Cockroach (CR) Allergen-specific Th2 Cell Responses Following Subcutaneous German Cockroach Allergen Immunotherapy (SCIT)

Author

Da Silva Antunes, Ricardo, primary, Frazier, April, additional, Pomés, Anna, additional, Calatroni, Augustin, additional, Wood, Robert, additional, O'Connor, George, additional, Pongracic, Jacqueline, additional, Hershey, Gurjit Khurana, additional, Kercsmar, Carolyn, additional, Gill, Michelle, additional, Liu, Andrew, additional, Zoratti, Edward, additional, Kattan, Meyer, additional, Busse, Paula, additional, Bacharier, Leonard, additional, Teach, Stephen, additional, Wheatley, Lisa, additional, Togias, Alkis, additional, Busse, William, additional, Jackson, Daniel, additional, and Sette, Alessandro, additional

Published
2023
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43. The Effect of Subcutaneous German Cockroach Immunotherapy (SCIT) on Nasal Allergen Challenge (NAC) and Cockroach-specific Antibody Responses Among Urban Children and Adolescents

Author

Zoratti, Edward, primary, Wood, Robert, additional, O, George, additional, Pongracic, Jacqueline, additional, Makhija, Melanie, additional, Hershey, Gurjit Khurana, additional, Sherenian, Michael, additional, Gill, Michelle, additional, Gruchalla, Rebecca, additional, Chambliss, Jeffrey, additional, Liu, Andrew, additional, Kattan, Meyer, additional, Busse, Paula, additional, Bacharier, Leonard, additional, Rivera-Spoljaric, Katherine, additional, Sheehan, William, additional, Jackson, Daniel, additional, Gergen, Peter, additional, Togias, Alkis, additional, Calatroni, Agustin, additional, Visness, Cynthia, additional, Cho, Kate, additional, Sette, Alessandro, additional, Altman, Matthew, additional, and Busse, William, additional

Published
2023
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44. Efficacy and safety of peanut epicutaneous immunotherapy in patients with atopic comorbidities

Author

Davis, Carla M., primary, Lange, Lars, additional, Beyer, Kirsten, additional, Fleischer, David M., additional, Ford, Lara, additional, Sussman, Gordon, additional, Oriel, Roxanne C., additional, Pongracic, Jacqueline A., additional, Shreffler, Wayne, additional, Bee, Katharine J., additional, Campbell, Dianne E., additional, Green, Todd D., additional, Lambert, Romain, additional, Peillon, Aurélie, additional, and Bégin, Philippe, additional

Published
2023
Full Text
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