128 results on '"Pompei G"'
Search Results
2. The Dydas - “Dynamic Data Analytics Services” Platform for HPC Big Data Analytics of Earth Observation and Geospatial Data
- Author
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Picchiani, M, primary, Maranesi, M, additional, Mastrucci, M, additional, Coltea, I. G., additional, Pompei, G., additional, and Di Giacomo, L., additional
- Published
- 2022
- Full Text
- View/download PDF
3. P393 MULTIMODALITY IMAGING IN ACROMEGALIC CARDIOMIOPATHY: A CASE REPORT
- Author
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Boccadoro, A, primary, Pompei, G, additional, Pavasini, R, additional, Passarini, G, additional, Micillo, M, additional, Campo, G, additional, Guardigli, G, additional, and Tonet, E, additional
- Published
- 2022
- Full Text
- View/download PDF
4. OC.08.4 DISEASE COURSE OF SEGMENTAL COLITIS ASSOCIATED TO DIVERTICULOSIS
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Sinagra, E., primary, Alloro, R., additional, Maida, M., additional, Rossi, F., additional, Conoscenti, G., additional, Testai, S., additional, Marasà, M., additional, Cristofalo, S., additional, Purpura, P., additional, Calandra, A., additional, Pompei, G., additional, Genova, R., additional, Di Ganci, S., additional, Tarantino, I., additional, and Raimondo, D., additional
- Published
- 2022
- Full Text
- View/download PDF
5. DISEASE COURSE OF SEGMENTAL COLITIS ASSOCIATED TO DIVERTICULOSIS
- Author
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Sinagra, E., additional, Alloro, R., additional, Maida, M., additional, Rossi, F., additional, Conoscenti, G., additional, Testai, S., additional, Marasà, M., additional, Cristofalo, S., additional, Purpura, P., additional, Calandra, A., additional, Pompei, G., additional, Genova, R., additional, Taormina, D., additional, Di Ganci, S., additional, Tarantino, I., additional, and Raimondo, D., additional
- Published
- 2022
- Full Text
- View/download PDF
6. AF.135 USE OF PERORAL CHOLANGIOSCOPY IN THE DIAGNOSIS OF INDETERMINATE STENOSIS: A MULTI-CENTRE EXPERIENCE
- Author
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Pallio, S., primary, Sinagra, E., additional, Santagati, A., additional, Pompei, G., additional, Conoscenti, G., additional, Romeo, F., additional, Borina, E., additional, Melita, G., additional, Tortora, A., additional, Rossi, F., additional, Tarantino, I., additional, and Raimondo, D., additional
- Published
- 2021
- Full Text
- View/download PDF
7. Novel oral anticoagulats for the treatment of left ventricle thrombosis: a systematic review and meta-analysis
- Author
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Serenelli, M, primary, Vitali, F, additional, Pavasini, R, additional, Tonet, E, additional, Pompei, G, additional, Passarini, G, additional, Tolomeo, P, additional, Enriquez, A, additional, Guardigli, G, additional, Campo, G, additional, and Bertini, M, additional
- Published
- 2021
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8. FOCAL ACTIVE COLITIS AS A PREDICTOR OF INFLAMMATORY BOWEL DISEASE: RESULTS FROM A SINGLE-CENTER EXPERIENCE
- Author
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Sinagra, E., Raimondo, D., Pompei, G., Fusco, G., Rossi, F., Tomasello, G., Leone, A., Francesco Cappello, Morreale, G. C., Midiri, F., Midiri, M., Rizzo, A. G., SINAGRA, E, RAIMONDO, D, POMPEI, G, FUSCO, G, ROSSI, F, TOMASELLO, G, LEONE, A, CAPPELLO, F, MORREALE, GC, MIDIRI, F, MIDIRI, M, and RIZZO, AG
- Subjects
Adult ,Aged, 80 and over ,Male ,Academic Medical Centers ,Incidental Findings ,Settore MED/12 - Gastroenterologia ,Colon ,Settore BIO/16 - Anatomia Umana ,Colonoscopy ,Middle Aged ,Colitis ,Inflammatory Bowel Diseases ,Prognosis ,Diagnosis, Differential ,Italy ,Disease Progression ,Humans ,Female ,focal colitis, inflammatory bowel diseases, colon microbiota, dysbiosis ,Prospective Studies ,Intestinal Mucosa ,Aged ,Retrospective Studies - Abstract
The term focal active colitis (FAC) is conventionally used to describe the presence of isolated cryptitis, characterized by an inflammatory infiltrate consisting of intraepithelial neutrophils and/or neutrophils invading the lumen of the criptae, with no other microscopic alteration of the colonic mucosa and, in particular, without the presence of signs of chronic inflammation. To date, only four studies, including one conducted in a pediatric population, have been performed to evaluate the clinical significance of this disease. The aim of this retrospective study on prospectively-collected data is to evaluate the clinical implications of the focal active colitis, since there still remains a marked uncertainty regarding this topic and about how often such a diagnosis will presage a diagnosis of inflammatory bowel disease (IBD). Clinical, endoscopic, and pathological data were retrospectively reviewed from 30 patients with focal active colitis, who had no other diagnostic findings on colorectal biopsy and no history of chronic inflammatory bowel disease. The histological findings were correlated with clinical diagnoses. Thirty patients (11 males, 19 females; age 24-80 years, median 56 years) (0.5%) out of 5,600 undergoing colonoscopy between January 2012 and December 2016 presented a definitive diagnosis of FAC. Follow-up ranged from 6 to 60 months (median 24 months). At endoscopy, 19 patients (63%) had mild and non-specific changes, such as mild mucosal erythema, while 11 (37%) had normal findings. Eight patients were documented as having irritable bowel syndrome, while nine cases could be attributed to the effects of drugs, five presented FAC as incidental finding, one a diagnosis of infectious colitis, and seven a diagnosis of IBD (4 with Crohns disease). FAC was confirmed to be a more significant predictor of IBD than the previous literature would indicate, even if larger prospective studies, targeted to study this relationship, are needed to understand more clearly its clinical significance.
- Published
- 2017
9. AMYLOIDOSIS AND INFLAMMATORY BOWEL DISEASE: FACT OR MITH?
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Sinagra,E, Ciofalo, M, Morreale, GC, Amvrosiadis,G, Damiani,P, Damiani,F, Pompei,G, Rizzo,AG, Canale,C, Mastrocinque,G, Raimondo D., TOMASELLO, Giovanni, CAPPELLO, Francesco, CARINI, Francesco, Sinagra,E, Ciofalo, M, Tomasello,G, Cappello,F, Morreale, GC, Amvrosiadis,G, Damiani,P, Damiani,F, Pompei,G, Rizzo,AG, Canale,C, Mastrocinque,G, Carini,F, and Raimondo D
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Settore MED/18 - Chirurgia Generale ,Settore MED/12 - Gastroenterologia ,Crohn' disease, Ulcerative Colitis, Amyloidisis, IBD - Abstract
Inflammatory Bowel Disease (IBD), which includes both Crohn's Disease (CD) and Ulcerative Colitis (UC), is a chronic idiopathic inflammatory disorder affecting the gastrointestinal tract. Extraintestinal manifestations (EIM) are common in patients with IBD, and occur in 6-47% of patients with CD or UC. EIM can involve organs other than the gastrointestinal tract such as skin, eyes, joints, biliary tract and kidneis. Renal and urinary involvement particularly occurs in 4-23% of patients with IBD. Among the renal complications of IBD, seconfary amyloidosis (AA-type, AAA) is a rare but serious complication. renal amyloidosis has been proven to be the most common lethal manifestation of IBD-associated amyloidosis, since renal involvement rapidly leads to end-stage renal failure. A few studies suggest that AAA is more prevalent in CD than in UC, mainly occurring in male patients with an extensive long-lasting and penetrating ddisease pattern. The therapeutic approaches of IBD-associated AAA are based both on control of the chronic inflammatory process that causes the production and storage of serum amyloid A (SAA), which is a precursor of the amyloid, as well as on destabilizing amyloid fibrils so that they can no longer maintain their pleated sheet configuration; however, in patients with end-stage renal disease, the only therapeutic options still available are hemodyalisis and renal transplantation. Whether effective treatment exists for AAA remain controversial.
- Published
- 2017
10. COULD THE ENDOSCOPIC RESECTION OF A LARGE RECTAL LEIOMYOMA BE AN EFFETCIVE AND SAFE TECHNIQUE?
- Author
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Sinagra,E, Pompei,G, Menozzi,M, Mandalà,S, Rossi,F, Martorana,G, Messina,M, Rizzo,AG, Calvaruso,M, Morreale,GC, Amvrosiadis,G, Raimondo D., TOMASELLO, Giovanni, CAPPELLO, Francesco, CARINI, Francesco, Sinagra,E, Tomasello,G, Pompei,G, Menozzi,M, Mandalà,S, Rossi,F, Martorana,G, Messina,M, Rizzo,AG, Calvaruso,M, Morreale,GC, Amvrosiadis,G, Cappello,F, Carini,F, and Raimondo D
- Subjects
Settore MED/18 - Chirurgia Generale ,Settore MED/12 - Gastroenterologia ,rectal leiomyoma, endoscopic resection, gastrointestinal stromal tumor - Abstract
Summary. Rectal leiomyomas are a rare conditions, with low reported incidence in literature and constitute about 0.1% of rectal tumours; in fact rectal leiomyomas occur in approximately 1 out of 2000-3000 rectal tumors. We report on a patient with a 3 cm semi-pedunculated colonic leiomyoma, which was successfully removed by endoscopic polypectomy after normal saline-epinephrine submucosal injection. When we encounter a tumor during a colonoscopic examination, we usually evaluate the tumor carefully and perform an endoscopic resection when we judge it is appropriate. When a symptomatic smooth muscle tumors smaller than 2 cm are incidentally found on colonoscopy, surgical resection is unnecessary. Furthermore, if a tumor can be lifted with a snare and it is either pedunculated or semi-pedunculated, endoscopic resection might be a safe option. For those tumors with wide-based or exoluminal growth, endoscopic removal should be avoided due to the higher risks of bleeding and perforation. The histological findings of the resected tumor are important. If there is any malignant element that can not be completely eradicated, we would suggest surgical treatment. We believe our process allows to avoid unnecessary surgery and reduces medical costs.
- Published
- 2016
11. FOCAL ACTIVE COLITIS AS A PREDICTOR OF INFLAMMATORY BOWEL DISEASE: RESULTS FROM A SINGLE-CENTER EXPERIENCE
- Author
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Raimondo, D., Pompei, G., Fusco, G., Rossi, F., Tomasello, G., Leone, A., Cappello, F., Morreale, G., Midiri, F., Midiri, M., and Rizzo, A.
- Subjects
Settore MED/12 - Gastroenterologia ,Settore BIO/16 - Anatomia Umana ,focal colitis, inflammatory bowel diseases, colon microbiota, dysbiosis - Published
- 2017
12. Psychopatological outcomes of immigrants at the Bologna transculturale psychiatric centre
- Author
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TARRICONE, ILARIA, PEDRINI, ELENA, ATTI, ANNA-RITA, BERARDI, DOMENICO, Morri M., Poggi F., Pompei G., Manganaro D., Tarricone I., Pedrini E., Morri M., Poggi F., Pompei G., Manganaro D., Atti A.R., and Berardi D.
- Published
- 2007
13. Management of Thoracic Outlet Compression Syndrome
- Author
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Tuscano, G., primary, Romani, F., additional, Pompei, G., additional, and Ricchi, E., additional
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- 1980
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- View/download PDF
14. [Our trend in conservative surgery in differentiated carcinoma of the thyroid]
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Scerrino G, Romano G, Salamone G, Ma, Farulla, Salamone S, Gambino G, Pompei G, and Buscemi G
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Adult ,Male ,Time Factors ,Age Factors ,Thyroid Gland ,Middle Aged ,Prognosis ,Carcinoma, Papillary ,Postoperative Complications ,Sex Factors ,Adenocarcinoma, Follicular ,Thyroidectomy ,Humans ,Lymph Node Excision ,Female ,Thyroid Neoplasms ,Follow-Up Studies - Abstract
Report as contribution to the controversy between supporters of total thyroidectomy versus "less than total" thyroidectomy.42 patient operated on over six years; 35 treated with total thyroidectomy, 7 with lobohystmectomy.In the patients who underwent total thyroidectomy we observed recurrent nerve lesions in 5.7%, hypoparathyroidism in 14.3% and 1 lymph nodal relapse (it was a cancer stay III); in patients who underwent lobohystmectomy, we observed 1 temporary recurrent nerve palsy (14.2%) and 1 lymph nodal relapse (14.2%).The choice between total thyroidectomy and lobohystermectomy depends upon different goals: reduction in risk of relapse in total thyroidectomy, to minimize complications in lobohystmectomy. In our series the risk of lymph nodal relapse seems to depend more on biological characters of the tumour than surgical tech of lymphadenectomy; however, this occurrence does not change prognosis.In our experience, potential multifocality of the disease, low risk of hyatrogenic lesions and easy postoperatory management make total thyroidectomy the our preferred technique. Informed consensus is mandatory in order to involve the patients to the best choice.
- Published
- 2002
15. [Non-toxic multinodular goitre: which surgery?]
- Author
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Scerrino G, Salamone G, Ma, Farulla, Romano G, Salamone S, Pompei G, and Buscemi G
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Adult ,Male ,Thyroidectomy ,Humans ,Female ,Middle Aged ,Aged ,Goiter, Nodular - Abstract
Evaluation of total thyroidectomy, subtotal thyroidectomy and lobectomy in the management of multinodular non-toxic goitre.225 patients: 101 total thyroidectomies, 64 sub-total thyroidectomies, 29 lobo-hystmectomies. Hemorrages, recurrent nerve palsies, post-operatory hypocalcemias, clinical and ultrasonographic relapses, undesired effects of ormonal therapy and hypothyroidism after partial resection (considered risk factor for recurrence) have been pointed out.All three procedures showed a low incidence of recurrent nerve palsy; lobectomy didn't show post-operatory hypocalcemia, that appeared respectively in 26.6% and 23% after sub-total and total thyroidectomy. Recurrence's percentage in patients followed-up, was 18.2% after lobectomy and 12.2% after sub-total thyroidectomy, but in that group we observed 46.9% of hypothyroidism (vs. 9.1% after lobectomy) and 8.6% of undesired effects of therapy. Reoperations showed inferior laringeal palsy and post-operatory hypocalcemia significantly more elevated.Compared to lobectomy, total thyroidectomy showed higher risk of hypoparathyroidism; compared to subtotal thyroidectomy, it showed on all occasions less incidence of complications. Endocrinological follow-up is easier after total thyroidectomy.According to our results, we deem the indications for lobectomy have to be limited to the patients having solitary nodule, undoubtedly benign, without familiarity or other environmental risk factor of goitre.
- Published
- 2002
16. Clinical, pathological and microbiological profiles of spontaneous enteropathies in growing rabbits
- Author
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Unione Nazionale Associazioni Produttori Avi-cunicoli, Badagliacca, P, Letizia, A., Candeloro, L., Di Provvido, A., Di Gennaro, A., Scattolini, S., Pompei, G., Pedicone, R., Scacchia, M., Unione Nazionale Associazioni Produttori Avi-cunicoli, Badagliacca, P, Letizia, A., Candeloro, L., Di Provvido, A., Di Gennaro, A., Scattolini, S., Pompei, G., Pedicone, R., and Scacchia, M.
- Abstract
[EN] In a rabbit production facility, health monitoring for enteropathies was performed in 15 production cycles for 20 mo. For each cycle, up to a hundred 35 d old rabbits weaned the same day were randomly selected, reared in the same fattening unit, but separately from the source batch and fed with the same feed except for antimicrobial supplementation. Clinical symptoms and enteric lesions of the selected group were recorded, using two checklists with binomial response (yes/no answer to a list of 54 clinical and enteric variables). The day after weaning, one week later, at the beginning of the enteric symptoms and 4-5 d after the start of the symptoms, inocula from the small intestine and caecum of selected animals were subjected to microbiological, C. spiroforme, Eimeria oocyst and rotavirus antigen detection tests. Representative samples of E. coli and C. perfringens isolates were tested, respectively, for serotype, biotype, eae, afr/2 genes and for a, b1, b2, e, i and enterotoxin toxin genes. The answers to the clinical-pathological variables were subjected to statistical analysis with a cluster analysis programme in order to obtain homogeneous, statistically significant groups of diseased animals (clusters). Then, the clusters were statistically associated with the laboratory outcomes. The cluster to which the enterotyphlitis lesions significantly contributed was associated with E. coli detection, E. coli O103 serotype detection and C. spiroforme ("several elements" variable). C. spiroforme ("rare elements" variable) was significantly associated with a cluster, characterised by a pathological profile consisting of bloating/rumbling noise and liquid content in stomach and caecum, without enteric inflammation. C. perfringens was significantly associated with a cluster, characterised by a pathological profile consisting of dilation/liquid content of small intestine, caecal impaction and mucoid content in the colon. Eighteen out of twenty-fi ve C. perfringens stra
- Published
- 2010
17. Type of estrogen receptor determines response to antiestrogen therapy
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Erica Villa, Dugani, A., Fantoni, E., Camellini, L., Buttafoco, P., Grottola, A., Pompei, G., Desantis, M., Ferrari, A., and Manenti, F.
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Adult ,Male ,Carcinoma, Hepatocellular ,Antineoplastic Agents, Hormonal ,Liver Neoplasms ,Estrogen Antagonists ,Pilot Projects ,Megestrol ,Middle Aged ,Tamoxifen ,Receptors, Estrogen ,Humans ,Female ,Cell Division ,Aged ,Follow-Up Studies ,ER ,antiesotrgens - Abstract
Failure of tamoxifen treatment for unresectable hepatocellular carcinomas (HCCs) might be caused by variant estrogen receptors (ERs) in some of these tumors. We therefore planned a study in which antihormonal therapy was done with 80 mg/day tamoxifen or 160 mg/day megestrol according to the presence of wild-type or exon 5-deleted variant ER transcripts. Growth rate (evaluated by MRI) of HCCs characterized by variant ER transcripts was 4 times more rapid than that of HCCs with wild-type ERs. Tumor volume in all patients with wild-type ERs was halved after 9 months of tamoxifen treatment, whereas megestrol in patients with variant ERs only slowed down tumor growth. Choosing antihormonal treatment according to the presence of wild-type or variant ERs in the tumor definitely improves the response rate to tamoxifen; in patients with tumors bearing variant ERs, megestrol causes only a temporary inhibition of tumor growth.
- Published
- 1996
18. FD-TD Analysis of Coplanar Waveguide to Slotilne Transitions Accounting for Air-Bridge, Shielding effects and Coaxial Connectors24th European Microwave Conference, 1994
- Author
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Mezzanotte, Paolo, Pompei, G., Roselli, Luca, and Sorrentino, Roberto
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- 1994
19. Clinical, pathological and microbiological profiles of spontaneous enteropathies in growing rabbits
- Author
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Badagliacca, P., primary, Letizia, A., additional, Candeloro, L., additional, Di Provvido, A., additional, Di Gennaro, A., additional, Scattolini, S., additional, Pompei, G., additional, Pedicone, R., additional, and Scacchia, M., additional
- Published
- 2010
- Full Text
- View/download PDF
20. FD-TD Analysis of Coplanar Waveguide to Slotilne Transitions Accounting for Air-Bridge, Shielding effects and Coaxial Connectors.
- Author
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Mezzanotte, P., Pompei, G., Roselli, L., and Sorrentino, R.
- Published
- 1994
- Full Text
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21. Pieloureterite Cistica: Considerazioni Su 12 Casi
- Author
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Pompei, G., Aldrovandi, S., Raspa, V., Brunelli, B., Bellelli, V., and Burgazzi, W.
- Published
- 1988
- Full Text
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22. Il Rene Escluso: Considerazioni Arteriografiche
- Author
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Pompei, G., Romani, F., Barbolini, G., Davolio-Marani, S., Cappelletti, V., Tavoni, F., and Ferrari, P.
- Published
- 1979
- Full Text
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23. Pouchitis: A tridimensional view
- Author
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Sinagra, E., Raimondo, D., Pompei, G., Morreale, G. C., Rossi, F., Marasà, S., Calvaruso, M., Mastrocinque, G., Mandalà, S., Martorana, G., Marchesa, P. E., Rizzo, A. G., Amvrosiadis, G., Francesco Cappello, Carini, F., Tomasello, G., Sinagra,E, Raimondo,D, Pompei,G, Morreeale,GC, Rossi,F, Marasà,S, Calvaruso,M, Mastrocinque,G, Mandalà,S, Martorana,G, Marchesa,PE, Rizzo,GA, Amvrosiadis,G, Cappello,F, Carini,F, and Tomasello,G
- Subjects
Settore MED/12 - Gastroenterologia ,Settore MED/18 - Chirurgia Generale ,pouchitis, ulcerative colitis, inflammatory bowel diseas, dysbiosis - Abstract
The preferred surgical treatment of ulcerative colitis (UC) and familial adenomatous polyposis (FAP) is represented by proctocolectomy with ileal pouch-anal anastomosis (IPAA). However, patients with UYC who have undergone IPAA are prone to develop several complications, which include surgery related/mecchanical complications; inflammatory or infectious disoreders; dysplasia or neoplasia; and systemic or metabolic disorders. Pouchitis, which is defined as the acute and/or chronic inflammation of the ileal reservoir, represent the most common long-term adverese sequela after IPAA. Gut microbiota play a pivotal role in the initiation and disease progression of pouchitis. Pouchitis can be classified according to the activity of the disease, the duration of the symptoms, the pattern of the disease or response to antibiotic therapy. Patients with IPAA for UC tend to experience a variety of symptoms that may eventually lead to pouch excision thereby necessitating the construction of a permanent ileostomy. To date, the ethiology, the diagnosis and the medical management of pouchitis represent a clinical challenge. In fact pouchitis range from a disease with an acute antibiotic-responsive presentation to a chronic antibiotic-refractory form, with subsequent different disease mechanism and clinical course. A tridimensional and multidisciplinar approach, including endoscopy, histology, and laboratory testing is widely helpful to identify the diferent phenotypes of the disease and to manage correctly its treatment.
24. Post nephectomy arteriovenous fistula: A reversible cause of hypertension and cardiac failure. Report of a case
- Author
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Pompei, G., Romani, F., Torricelli, P., and Erica Villa
- Published
- 1983
25. Computer tomography in diagnosis of synovial cysts of the popliteal region
- Author
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Calo, M., Torricelli, P., and Pompei, G.
- Published
- 1984
26. Computed tomography and bone scintigraphy in evaluation of osteoid osteoma|TOMOGRAFIA COMPUTERIZZATA E SCINTIGRAFIA NELLA VALUTAZIONE DELL'OSTEOMA OSTEOIDE
- Author
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Torricelli, P., Romani, F., Pompei, G., and Canossi, G.
- Published
- 1985
27. Eritropoiesi extramidollare intratoracica. Considerazioni clinico radiologiche su due casi di talassemia minor
- Author
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Romani, F., Emilia, Giovanni, Pompei, G., Federico, Massimo, and Torricelli, Pietro
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Ematopoiesi extramidollare ,talassemia ,radiodiagnostica - Published
- 1983
28. Fatal outcome in a case of benign lymphangioma of the spleen: a case report
- Author
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Pompei, G., Erica Villa, and Pantusa, M.
- Published
- 1982
29. Influence of small-bowel transit time on dietary cholesterol absorption in human beings
- Author
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Zaniol P, Pompei G, Nicola Carulli, Rossella Iori, Ponz de Leon M, and Barbolini G
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Adolescent ,Transit time ,Absorption (skin) ,Cholesterol, Dietary ,chemistry.chemical_compound ,Internal medicine ,Intestine, Small ,medicine ,Humans ,Cholesterol absorption ,Cholesterol ,business.industry ,General Medicine ,Limiting ,Middle Aged ,Endocrinology ,chemistry ,Intestinal Absorption ,Intestinal transit ,lipids (amino acids, peptides, and proteins) ,Female ,business ,Gastrointestinal Motility ,Dietary Cholesterol - Abstract
ALTHOUGH the individual steps in the absorptive process of cholesterol have been studied in great detail in recent years,1 , 2 there is still relatively little information on the factors regulating and influencing cholesterol absorption. Recent studies have shown that in certain guinea pigs that are resistant to the pathologic effect of dietary cholesterol, intestinal transit time is more rapid than in other guinea pigs that become hypercholesterolemic, suggesting that intestinal transit time allows less absorption of cholesterol in the former group, thus limiting cholesterol accumulation in body tissues.3 In view of these findings, it seemed of interest to investigate the relation . . .
- Published
- 1982
30. Selective intracoronary thrombolysis in acute myocardial infarction
- Author
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Pompei, G., Romani, F., and Torricelli, P.
- Published
- 1984
31. THIN NEEDLE PERCUTANEOUS CHOLANGIOGRAPHY IN JAUNDICED PATIENTS WITH BILIARY-ENTERIC ANASTOMOSIS
- Author
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Pompei, G. and Erica Villa
32. Toxin genotyping of Clostridium perfringens strains using a polymerase chain reaction protocol
- Author
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Badagliacca, P., Di Provvido, A., Scattolini, S., Pompei, G., and Elisabetta Di Giannatale
- Subjects
ADP Ribose Transferases ,DNA, Bacterial ,Genotyping ,Rabbit ,lcsh:Veterinary medicine ,Genotype ,Animal ,Clostridium perfringens ,Clostridial toxin ,Bacterial Toxins ,Polymerase Chain Reaction ,Enterotoxins ,PCR ,Italy ,Species Specificity ,lcsh:SF600-1100 ,Animals ,lcsh:Animal culture ,Rabbits ,lcsh:SF1-1100 - Abstract
A polymerase chain reaction protocol consisting of a multiplex to identify the cpa, cpb1, cpetx, cpi genes and a duplex to identify the cpe and cpb2 genes encoding for alpha, beta1, epsilon, eta, enterotoxin and beta2 toxins, respectively, was applied to DNA extracted from two collections of Clostridium perfringens strains. The first collection involved 19 isolates from rabbits. The second collection of 41 isolates came from routine necropsies. The cpa gene alone, or in association with the cpb2 gene, was detected in all DNA samples examined. The cpa gene, together with cpb2 gene, were detected in seven of the rabbit C. perfringens strains (36.8%) and in nine isolates from necropsies (21.9%). The cpa gene was found in 63.2% of rabbit strains and 76.9% of strains from other animal species. In rabbits, the pathological lesions associated with C. perfringens detection were predominantly forms of non-inflammatory enteropathies. In other species, C. perfringens was mainly associated with congestive-haemorrhagic enteropathy, but also with fatal traumatic lesions, degenerative diseases and organs with post-mortem autolysis. No clear correlation was observed between detection of beta2 toxin gene and species-specific pathological features.
33. Our trend about conservative surgery in differentiated thyroid carcinoma,Nostro orientamento sugli interventi conservativi nel carcinoma differenziato della tiroide
- Author
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Gregorio Scerrino, Romano, G., Salamone, G., Airò Farulla, M., Salamone, S., Gambino, G., Pompei, G., and Buscemi, G.
34. Could the endoscopic resection of a large rectal leiomyoma be an effective and safe technique?
- Author
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Sinagra, E., GIOVANNI TOMASELLO, Pompei, G., Menozzi, M., Mandalà, S., Rossi, F., Martorana, G., Messina, M., Rizzo, A. G., Calvaruso, M., Morreale, G. C., Amvrosiadis, G., Francesco, C., and Raimondo, D.
35. The multinodular non-toxic goitre: What a surgery?,Il gozzo multinodulare non tossico: Quale chirurgia?
- Author
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Gregorio Scerrino, Salamone, G., Farulla, M. A., Romano, Ga, Salamone, S., Pompei, G., and Buscemi, G.
36. Arteriographic and tomodensitometric pictures in three cases of popliteal artery entrapment
- Author
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Calò, M., primary, Crisi, G., additional, de Santis, M., additional, Pompei, G., additional, and Torricelli, P., additional
- Published
- 1985
- Full Text
- View/download PDF
37. Contrast Associated Acute Kidney Injury and Mortality in Older Adults with Acute Coronary Syndrome: A Pooled Analysis of the FRASER and HULK Studies
- Author
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Matteo Tebaldi, Elisa Maietti, Graziella Pompei, Roberta Campana, Francesco Vitali, Giovanni Grazzi, Gianni Mazzoni, Matteo Serenelli, Simone Biscaglia, Giulia Bugani, Gianluca Campo, Gioele Fabbri, Paolo Cimaglia, Andrea Rubboli, Alessio Fiorio, Elisabetta Tonet, Rita Pavasini, Pavasini R., Tebaldi M., Bugani G., Tonet E., Campana R., Cimaglia P., Maietti E., Grazzi G., Pompei G., Fabbri G., Fiorio A., Rubboli A., Mazzoni G., Vitali F., Serenelli M., Campo G., and Biscaglia S.
- Subjects
medicine.medical_specialty ,Acute coronary syndrome ,Contrast induced acute kidney injury ,medicine.medical_treatment ,Renal function ,Socio-culturale ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,Article ,Percutaneous coronary intervention ,Physical performance ,03 medical and health sciences ,Older patient ,0302 clinical medicine ,Older patients ,Internal medicine ,medicine ,030212 general & internal medicine ,Mortality ,Risk factor ,business.industry ,Acute kidney injury ,General Medicine ,medicine.disease ,Pooled analysis ,Conventional PCI ,Medicine ,business - Abstract
Whether contrast-associated acute kidney injury (CA-AKI) is only a bystander or a risk factor for mortality in older patients undergoing percutaneous coronary intervention (PCI) is not well understood. Data from FRASER (NCT02386124) and HULK (NCT03021044) studies have been analysed. All patients enrolled underwent coronary angiography. The occurrence of CA-AKI was defined based on KDIGO criteria. The primary outcome of the study was to test the relation between CA-AKI and 3-month mortality. Overall, 870 older ACS adults were included in the analysis (mean age 78 ± 5 years, 28% females). CA-AKI occurred in 136 (16%) patients. At 3 months, 13 (9.6%) patients with CA-AKI died as compared with 13 (1.8%) without it (p <, 0.001). At multivariable analysis, CA-AKI emerged as independent predictor of 3-month mortality (HR 3.51, 95%CI 1.05–7.01). After 3 months, renal function returned to the baseline value in 78 (63%) with CA-AKI. Those without recovered renal function (n = 45, 37%) showed an increased risk of mortality as compared to recovered renal function and no CA-AKI subgroups (HR 2.01, 95%CI 1.55–2.59, p = 0.009 and HR 2.71, 95%CI 1.45–5.89, p <, 0.001, respectively). In conclusion, CA-AKI occurs in a not negligible portion of older MI patients undergoing invasive strategy and it is associated with short-term mortality.
- Published
- 2021
38. INFLAMMATION IN IRRITABLE BOWEL SYNDROME: MYTH OR NEW TREATMENT TARGET?
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Giovanni Tomasello, Francesco Cappello, Georgios Amvrosiadis, Francesca Rossi, Dario Raimondo, Gaetano Cristian Morreale, Aroldo Rizzo, Emanuele Sinagra, Attilio Ignazio Lo Monte, Giancarlo Pompei, Sinagra,E, Pompei,G, Tomasello,G, Cappello,F, Morreale,GC, Amvrosiadis,G, Rossi,F, Lo Monte,AI, Rizzo,G, and Raimondo,D
- Subjects
Pathology ,medicine.medical_specialty ,MEDLINE ,Anti-Inflammatory Agents ,Inflammation ,Cochrane Library ,Bioinformatics ,Mast cell ,03 medical and health sciences ,0302 clinical medicine ,Treatment targets ,Gastrointestinal Agents ,Intestinal inflammation ,medicine ,Animals ,Humans ,Molecular Targeted Therapy ,Topic Highlight ,Intestinal Mucosa ,Irritable bowel syndrome ,Settore MED/12 - Gastroenterologia ,Mechanism (biology) ,business.industry ,Settore BIO/16 - Anatomia Umana ,Gastroenterology ,General Medicine ,Mast cells ,Neuroendocrine cells ,medicine.disease ,Enteritis ,Clinical trial ,Settore MED/18 - Chirurgia Generale ,030220 oncology & carcinogenesis ,Neuroendocrine cell ,030211 gastroenterology & hepatology ,medicine.symptom ,Inflammation Mediators ,business - Abstract
Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome (IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications describing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanisms underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism.
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- 2016
39. Primary schwannoma of the thyroid gland involving the isthmus: report of a case
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Giancarlo Pompei, Giuseppa Graceffa, Ada Maria Florena, Mario Adelfio Latteri, Irene Gentile, Calogero Cipolla, Graceffa, G, Cipolla, C, Florena, AM, Gentile, I, Pompei, G, and Latteri, M
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Male ,endocrine system ,Pathology ,medicine.medical_specialty ,endocrine system diseases ,medicine.medical_treatment ,Thyroid Gland ,Schwannoma, Thyroid gland ,Settore MED/08 - Anatomia Patologica ,Schwannoma ,Surgical oncology ,otorhinolaryngologic diseases ,medicine ,Humans ,Thyroid Neoplasms ,Cold nodule ,Pathological ,Histological examination ,Total thyroidectomy ,business.industry ,Thyroid ,Thyroidectomy ,General Medicine ,Middle Aged ,medicine.disease ,nervous system diseases ,Settore MED/18 - Chirurgia Generale ,Treatment Outcome ,medicine.anatomical_structure ,Surgery ,business ,Neurilemmoma - Abstract
Primary thyroid schwannomas are extremely rare tumors and there are very few reports of such tumors in the literature. This report presents a rare case of schwannoma involving the isthmus of the thyroid in a 47-year-old male, presenting as a symptomatic predominating cold nodule within a multinodular goiter. The patient underwent total thyroidectomy. The histological examination indicated an Antoni A-type schwannoma. The clinical, radiological and pathological findings of the tumor are discussed, emphasizing the difficulty in reaching a correct preoperative diagnosis. Only 18 cases of primary schwannoma of the thyroid gland have so far been described in the literature and, this is only the second report of thyroid schwannoma localized in the isthmus.
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- 2012
40. CLINICAL OUTCOMES OF SELF-EXPAMDABLE METALLIC STENTS IN PALLIATION OF MALIGNANT ANASTOMOTIC STRICTURES: A SINGLE CENTER EXPERIENCE
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Giancarlo Pompei, Gaetano Cristian Morreale, Guido Martorana, T Facella, Dario Raimondo, Pierenrico Marchesa, Rosario Squatrito, Massimiliano Spada, Attilio Ignazio Lo Monte, Ennio La Rocca, Emanuele Sinagra, Georgios Amvrosiadis, Francesca Rossi, Marco Messina, Giovanni Tomasello, Marco Ciofalo, Raimondo, D, Sinagra, E, Facella, T, Rossi, F, Messina, M, Spada, M, Martorana, G, Marchesa, PE, Squatrito, R, Tomasello, G, Lo Monte, AI, Pompei, G, Morreale, GC, Amvrosiadis,G, Ciofalo, M, and La Rocca, E
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Marketing ,Pharmacology ,Organizational Behavior and Human Resource Management ,medicine.medical_specialty ,Settore MED/12 - Gastroenterologia ,Palliative treatment ,business.industry ,Strategy and Management ,medicine.medical_treatment ,Pharmaceutical Science ,Stent ,Gastric outlet obstruction ,Anastomosis ,medicine.disease ,Single Center ,Surgery ,Settore MED/18 - Chirurgia Generale ,gastric cancer, palliation, self-expandable metallic stent, Billrot-II reconstruction ,Self-expandable metallic stent ,Drug Discovery ,Medicine ,Gastrectomy ,Radiology ,business ,Covered stent - Abstract
Background: self-expandable metallic stents (SEMS) are employed as the preferred non surgical palliative treatment for gastric outlet obstruction due to malignancies. Metallic stents are often employed to treat malignant anastomotic obstructions after surgicsl interventions as esophagojejunostomy, gastrojejunostomy and esophagogastrojejunostomy. Methods: this case series reports prospectively the clinical outcomes of SEMS in the palliative care of malignant anastomotic strictures caused by the recurrence gastric cancer follwing gastric surgery as oncological curative treatment, in a series of nine consecutive patients, treated between January 2009 and december 2012 in our center. Results: Nine patients (M:F=8:1) were enrolled in the study. The operation was a total gastrectomy with esophagogastrojejunostomy (n=4), subtotal gastrectomy with Bilroth-II reconstruction (n=4), subtotal gastrectomy with Billroth-II reconstruction (n=3), and subtotal gastrectomy with esophagogastrostomy (n=2). The technical success rate was 88,9%, and the clinical success rate was 88.9%. The reostruction of the stent, due to the ingrowth of the tumor, occurred in 1 patient (11,1%) within 1 month after stent placement. the migration of the stent occurred after the placement of a covered stent in 1 patient who underwent a subtotal gastrectomy (with Billroth-II reconstruction). A case o partial stent dislodgement was treated with the placement of a second stent. The median survival period was 180 days (range, 30-240 days) and the median stent patency was 45 days 8range, 30-90 days). Conclusions: Although the number of the patients treated with SEMS results, in this series, almost small to certainly judge the safety and feasibility of SEMS, we believe that the endoscopic insertion of SEMS seems to be a safe, easily feasible, and effective treatment in the palliative care of malignant anastomotic strictures caused by the recurrence of gastric cancer following gastric surgery. The technical and clinical success, and the onset of complications of this procedure are influenced by several factors, such as the type of anastomosis, the technical features of the stent, and the extent of the underlying tumor.
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- 2015
41. Assessment of 'grading' with Ki-67 and c-kit immunohistochemical expressions may be a helpful tool in management of patients with flat epithelial atypia (FEA) and columnar cell lesions (CCLs) on core breast biopsy
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Antonio Russo, Rosa Maria Tomasino, Valentina Agnese, Giancarlo Pompei, Gaetana Rinaldi, Vincenza Morello, Arianna Gullo, Tomasino, RM, Morello, V, Gullo, A, Pompei, G, Agnese, V, Russo, A, and Rinaldi, G
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Adult ,Pathology ,medicine.medical_specialty ,Physiology ,Biopsy ,Clinical Biochemistry ,columnar cell lesion ,c-kit expression ,Settore MED/08 - Anatomia Patologica ,Carcinoma ,medicine ,Atypia ,Humans ,Breast ,Pathological ,Grading (tumors) ,Aged ,medicine.diagnostic_test ,biology ,business.industry ,Antibodies, Monoclonal ,Epithelial Cells ,Cell Biology ,Middle Aged ,Hyperplasia ,medicine.disease ,Immunohistochemistry ,Proto-Oncogene Proteins c-kit ,Ki-67 Antigen ,flat epithelial atypia ,Ki-67 ,biology.protein ,Female ,cytological grading ,business - Abstract
It is essential to reach a better understanding of "flat epithelial atypia/columnar cell lesions" (FEA/CCLs) in breast core biopsies. Our aim was to explore their biological nature, in order to predict the likelihood of an upgrade to carcinoma. "Cytological grading" has been specially focused, in view of its possible utility in the choice of management. One hundred thirty of a total of 900 cases core needle (CN)/vacuum-assisted biopsies (VABs), with diagnoses of "hyperplasia" and "atypia" were retrospectively re-evaluated. Pathological findings of further excision biopsies (FEBs) performed in 40/75 patients with follow-up were compared with the previous diagnoses. In all cases, both Ki-67 and c-kit immunoreactivities were explored and compared with both normal breast tissues and subsequently documented cancers, with special reference to the hyperplastic FEA/CCLs, with "mild" atypia (FEA/CCHAm). Sixteen cases were re-diagnosed as "usual ductal hyperplasia" (UDH), 60 as "columnar cell hyperplasia" (CCH), and 54 as FEA/CCHA, 30 of which FEA/CCHAm and 24 FEA/CCHAh (with high atypia). Significantly, the Ki-67 index proved to be on the increase and c-kit expression on the decrease in FEA/CCHA lesions, mainly in the FEA/CCHAh group and in the subsequently observed cancers, compared with either benign tissues or the FEA/CCH cases. It was also significant that most of the carcinomas were found in FEBs within the FEA/CCHAh group. In this study cytological grading, together with Ki-67 and c-kit indices, proved to be helpful in FEA/CCLs evaluation. With regard to FEA/CCHAm lesions, an adequate surveillance appears to be a more appropriate management tool than FEB, as a result of their biological nature and behavior.
- Published
- 2009
42. Increased expression of transketolase-like-1 in papillary thyroid carcinomas smaller than 1.5 cm in diameter is associated with lymph-node metastases
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Antonio Russo, Daniela Cabibi, Anna Martorana, Giancarlo Pompei, Francesco Cappello, Marco Calogero Amato, Johannes F. Coy, Monica Zerilli, Carla Giordano, Vito Rodolico, ZERILLI, M, AMATO, MC, MARTORANA, A, CABIBI, D, COY, JF, CAPPELLO, F, POMPEI, G, RUSSO, A, GIORDANO, C, and RODOLICO, V
- Subjects
Adult ,Male ,Cancer Research ,Pathology ,medicine.medical_specialty ,Adolescent ,Tumor suppressor gene ,Gene Expression ,Settore MED/08 - Anatomia Patologica ,Thyroid carcinoma ,medicine ,Humans ,Thyroid Neoplasms ,Risk factor ,Lymph node ,Aged ,papillary thyroid carcinoma (PTC), lymph-node (LN) metastases, transketolase protein (TKTL1), tumor recurrence ,biology ,business.industry ,Incidence (epidemiology) ,Cancer ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Carcinoma, Papillary ,medicine.anatomical_structure ,Oncology ,Lymphatic Metastasis ,Disease Progression ,biology.protein ,Cancer research ,Female ,Transketolase ,Antibody ,business - Abstract
BACKGROUND. Patients with small papillary thyroid carcinoma (PTC) may have a high incidence of regional lymph-node (LN) metastases at presentation, and these are considered to be an independent risk factor for tumor recurrence. A mutated transketolase transcript (TKTL1) has been found up-regulated in different human malignancies, and strong TKTL1 protein expression has been associated with aggressiveness and poor patient survival in several epithelial cancers. METHODS. TKTL1 protein expression was analyzed in 256 consecutive cases of PTCs ≤1.5 cm by immunohistochemistry with a specific anti-TKTL1 antibody. RNA analysis was performed by real-time polymerase chain reaction (PCR) in all cases for which frozen material was available, which resulted in 55 fragments of PTC. RESULTS. Increased levels of TKTL1 transcript were detected in 50 of 55 analyzed tumors compared with their corresponding normal tissues. Significant differences in TKTL1 transcript levels were found between cases of PTC with and without LN metastases. In primary tumors, immunoreactivity for TKTL1 was detected in the majority of cases, ranging from 0% to 95.0% (mean, 50.11% ± 27.75%). A significant association was found between TKTL1 protein expression and the presence of multifocality, bilaterality, extrathyroidal extension, vascular invasion, sclerosis, and LN metastases. In cases with LN metastases, a positive correlation was found between the TKTL1 protein expression in primary tumors and the number of metastatic LNs as well as the diameter of the largest metastatic area in LNs. CONCLUSIONS. These findings suggest that TKTL1 overexpression in PTC ≤1.5 cm may be considered a factor that facilitates tumor growth and progression. Cancer 2008. © 2008 American Cancer Society.
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- 2008
43. ISTIOCITOMA FIBROSO ANGIOMATOIDE: DESCRIZIONE DI UN CASO ED INQUADRAMENTO NOSOGRAFICO
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MARTORANA, Anna, POMPEI, Giancarlo, CABIBI, Daniela, SPANO' G, MARTORANA A, SPANO' G, POMPEI G, and CABIBI D
- Published
- 2007
44. Advancing the access to cardiovascular diagnosis and treatment among women with cardiovascular disease: a joint British Cardiovascular Societies' consensus document.
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Tayal U, Pompei G, Wilkinson I, Adamson D, Sinha A, Hildick-Smith D, Cubbon R, Garbi M, Ingram TE, Colebourn CL, Camm CF, Guzik TJ, Anderson L, Page SP, Wicks E, Jenkins P, Rosen SD, Eftychiou S, Roberts E, Eftekhari H, Probert H, Cowie A, Thakkar R, Moore J, Berry C, Captur G, Deshpande A, Brown S, Malkin R, Harrison M, Lawson C, Ng GA, and Kunadian V
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- Female, Humans, Cardiology standards, Consensus, Risk Factors, Sex Factors, Societies, Medical, United Kingdom epidemiology, Cardiovascular Diseases diagnosis, Cardiovascular Diseases epidemiology, Cardiovascular Diseases therapy, Health Services Accessibility standards, Healthcare Disparities, Women's Health
- Abstract
Despite significant progress in cardiovascular pharmacotherapy and interventional strategies, cardiovascular disease (CVD), in particular ischaemic heart disease, remains the leading cause of morbidity and mortality among women in the UK and worldwide. Women are underdiagnosed, undertreated and under-represented in clinical trials directed at management strategies for CVD, making their results less applicable to this subset. Women have additional sex-specific risk factors that put them at higher risk of future cardiovascular events. Psychosocial risk factors, socioeconomic deprivation and environmental factors have an augmented impact on women's cardiovascular health, highlighting the need for a holistic approach to care that considers risk factors specifically related to female biology alongside the traditional risk factors. Importantly, in the UK, even in the context of a National Health Service, there exist significant regional variations in age-standardised mortality rates among patients with CVD. Given most CVDs are preventable, concerted efforts are necessary to address the unmet needs and ensure parity of care for women with CVD. The present consensus document, put together by the British Cardiovascular Society (BCS)'s affiliated societies, specifically portrays the current status on the sex-related differences in the diagnosis and treatment of each of the major CVD areas and proposes strategies to overcome the barriers in accessing diagnoses and treatments among women. This document aims at raising awareness of the scale of the current problem and hopes to stimulate a multifaceted approach to address sex disparities and enable future comprehensive sex- and gender-based research through collaboration across different affiliated societies within the BCS., Competing Interests: Competing interests: VK is an associate editor for Heart BMJ and is NIHR National Cardiovascular Research Lead, Research Delivery Network., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2024
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45. Role of physiology in the management of multivessel disease among patients with acute coronary syndrome.
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Ganzorig N, Pompei G, Jenkins K, Wang W, Rubino F, Gill K, and Kunadian V
- Abstract
Multivessel coronary artery disease (CAD), defined as ≥50% stenosis in 2 or more epicardial arteries, is associated with a high burden of morbidity and mortality in acute coronary syndrome (ACS) patients. A salient challenge for managing this cohort is selecting the optimal revascularisation strategy, for which the use of coronary physiology has been increasingly recognised. Fractional flow reserve (FFR) is an invasive, pressure wire-based, physiological index measuring the functional significance of coronary lesions. Understanding this can help practitioners evaluate which lesions could induce myocardial ischaemia and, thus, decide which vessels require urgent revascularisation. Non-hyperaemic physiology-based indices, such as instantaneous wave-free ratio (iFR), provide valid alternatives to FFR. While FFR and iFR are recommended by international guidelines in stable CAD, there is ongoing discussion regarding the role of physiology in patients with ACS and multivessel disease (MVD); growing evidence supports FFR use in the latter. Compelling findings show FFR-guided complete percutaneous coronary intervention (PCI) can reduce adverse cardiovascular events, mortality, and repeat revascularisations in ACS and MVD patients compared to angiography-based PCI. However, FFR is limited in identifying non-flow-limiting vulnerable plaques, which can disadvantage high-risk patients. Here, integrating coronary physiology assessment with intracoronary imaging in decision-making can improve outcomes and quality of life. Further research into novel physiology-based tools in ACS and MVD is needed. This review aims to highlight the key evidence surrounding the role of FFR and other functional indices in guiding PCI strategy in ACS and MVD patients., Competing Interests: The authors have no conflicts of interest to declare.
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- 2024
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46. The association of inflammatory biomarkers and long-term clinical outcomes in older adults with non-ST elevation acute coronary syndrome.
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Dirjayanto VJ, Martin-Ruiz C, Pompei G, Rubino F, and Kunadian V
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- Humans, Male, Female, Aged, Aged, 80 and over, Follow-Up Studies, Cohort Studies, Inflammation blood, C-Reactive Protein metabolism, C-Reactive Protein analysis, Time Factors, Interleukin-6 blood, Treatment Outcome, Prognosis, Peroxidase blood, Biomarkers blood, Acute Coronary Syndrome blood, Acute Coronary Syndrome mortality, Acute Coronary Syndrome diagnosis
- Abstract
Background: The prognostic significance of inflammatory markers on the long-term risk of major adverse cardiovascular and cerebrovascular events (MACCE) in older NSTEACS patients remains unclear., Methods: NSTEACS patients aged 75 and older were recruited to the multicentre cohort study Improve Cardiovascular Outcomes in High-Risk PatieNts with Acute Coronary Syndrome (ICON1). Inflammatory markers including interleukin-6 (IL-6), myeloperoxidase (MPO), high-sensitivity C-reactive protein (hsCRP), fibrinogen and tumor necrosis factor-alpha (TNF-α) were collected at baseline. Primary outcome was MACCE consisting of all-cause mortality, reinfarction, stroke/transient ischaemic attack, urgent revascularization, and significant bleeding at 5-year follow-up., Results: There were 230 patients with baseline IL-6 (median age 80.9 [interquartile range (IQR):78.2-83.9] years). High IL-6 was not associated with MACCE, but it was independently associated with all-cause mortality (adjusted hazard ratio [aHR]: 2.26 [95% Confidence Interval (CI):1.34-3.82]; P = 0.002). For patients with hsCRP (n = 260, median age 80.9 [IQR:77.9-84.1] years), higher levels were significantly associated with increased risk of MACCE (aHR:1.77 [95% CI:1.26-2.49], P = 0.001). In the cohort with MPO (230 patients, median age 80.9 [IQR:78.2-83.9] years), lower MPO was independently associated with the risk of MACCE (aHR: 0.67 [95%CI:0.46-0.96]; P = 0.029). There was no prognostic significance with fibrinogen and TNF-α., Conclusion: Among older NSTEACS patients, elevated IL-6 and hsCRP were associated with increased risk of all-cause mortality and MACCE, respectively. Low MPO levels were associated with higher MACCE. Further studies are required to determine how these biomarkers should influence treatment strategy in this understudied subset., Clinical Trial Registration: NCT01933581., Competing Interests: Declaration of competing interest None., (Copyright © 2024 Elsevier B.V. All rights reserved.)
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- 2024
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47. Non-invasive vascular measures as prognostic predictors for older patients with non-ST elevation acute coronary syndrome.
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Dirjayanto VJ, Pompei G, Rubino F, Biscaglia S, Campo G, Mihailidou AS, den Ruijter H, and Kunadian V
- Subjects
- Humans, Female, Male, Aged, Prognosis, Aged, 80 and over, Endothelium, Vascular physiopathology, Risk Factors, Predictive Value of Tests, Carotid-Femoral Pulse Wave Velocity methods, Risk Assessment methods, Acute Coronary Syndrome physiopathology, Acute Coronary Syndrome mortality, Acute Coronary Syndrome diagnosis, Acute Coronary Syndrome therapy, Carotid Intima-Media Thickness, Vascular Stiffness physiology
- Abstract
Background: Adverse cardiac events are common in older patients with non-ST elevation acute coronary syndrome (NSTEACS), yet prognostic predictors are still lacking. This study investigated the long-term prognostic significance of non-invasive measures including endothelial function, carotid intima-media thickness (CIMT), and vascular stiffness in older NSTEACS patients referred for invasive treatment., Methods: NSTEACS patients aged 75 years and older recruited to a multicentre cohort study (NCT01933581) were assessed for baseline endothelial function using endoPAT logarithm of reactive hyperemia index (LnRHI), CIMT using B-mode ultrasound, and vascular stiffness using carotid-femoral pulse wave velocity (cfPWV). Long-term outcomes included major adverse cardiovascular events (MACE), a composite of death, reinfarction, urgent revascularization, stroke/transient ischemic attack, and significant bleeding., Results: Recruitment resulted in 214 patients assessed for LnRHI, 190 patients assessed for CIMT and 245 patients assessed for cfPWV. For LnRHI group (median follow-up 4.73 years [IQR: 1.41-5.00]), Cox regression analysis revealed a trend towards increased risk of MACE (HR: 1.24 [95% CI: 0.80-1.93]; P = 0.328) and mortality (HR: 1.49 [95% CI: 0.86-2.59]; P = 0.157), but no significance was reached. No difference for other components of MACE was found. For CIMT group (median follow up 4.74 years [IQR: 1.55-5.00]), no statistically significant difference in MACE was found (HR: 0.92 [95% CI: 0.53-1.59]; P = 0.754). Similarly, for cfPWV group (median follow-up 4.96 years [IQR: 1.55-5.00]), results did not support prognostic significance (for MACE, HR: 0.95 [95% CI: 0.65-1.39]; P = 0.794)., Conclusion: Endothelial function, CIMT and vascular stiffness were proven unsuitable as strong prognostic predictors in older patients with NSTEACS., Clinical Trial Registration: NCT01933581., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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48. Novel diagnostic approaches and management of coronary microvascular dysfunction.
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Pompei G, Ganzorig N, Kotanidis CP, Alkhalil M, Collet C, Sinha A, Perera D, Beltrame J, and Kunadian V
- Abstract
The mechanism underlying ischaemic heart disease (IHD) has been primarily attributed to obstructive coronary artery disease (CAD). However, non-obstructive coronary arteries are identified in >50% of patients undergoing elective coronary angiography, recently leading to growing interest in the investigation and management of angina/ischaemia with non-obstructive coronary arteries (ANOCA/INOCA). INOCA is an umbrella term encompassing a multiple spectrum of possible pathogenetic entities, including coronary vasomotor disorders which consist of two major endotypes: coronary microvascular dysfunction (CMD) and vasospastic angina. Both conditions can coexist and be associated with concomitant obstructive CAD. Particularly, CMD refers to myocardial ischaemia due to reduced vasodilatory capacity of coronary microcirculation secondary to structural remodelling or impaired resting microvascular tone (functional) or a combination of both. CMD is not a benign condition and is more prevalent in women presenting with chronic coronary syndrome compared to men. In this setting, an impaired coronary flow reserve has been associated with increased risk of major adverse cardiovascular events. ANOCA/INOCA patients also experience impaired quality of life and associated increased healthcare costs. Therefore, research in this scenario has led to better definition, classification, and prognostic stratification based on the underlying pathophysiological mechanisms. The development and validation of non-invasive imaging modalities, invasive coronary vasomotor function testing and angiography-derived indices provide a comprehensive characterisation of CMD. The present narrative review aims to summarise current data relating to the diagnostic approach to CMD and provides details on the sequence that therapeutic management should follow., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)
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- 2024
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49. Complete vs Culprit-Only Revascularization in Older Patients With Myocardial Infarction and High Bleeding Risk: A Randomized Clinical Trial.
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Erriquez A, Campo G, Guiducci V, Escaned J, Moreno R, Casella G, Menozzi M, Cerrato E, Sacchetta G, Menozzi A, Santos IA, Ibañes EG, Scarsini R, Vadalà G, Andò G, Díez-Gil JL, d'Amore SM, Capecchi A, Colaiori I, Gallo F, Pavasini R, Marrone A, Pompei G, Lanzilotti V, Dudek D, Barbato E, Tebaldi M, and Biscaglia S
- Subjects
- Humans, Male, Female, Aged, Aged, 80 and over, Myocardial Revascularization methods, Percutaneous Coronary Intervention methods, Coronary Angiography, Risk Factors, Myocardial Infarction, Hemorrhage epidemiology
- Abstract
Importance: Patients with high bleeding risk (HBR) have a poor prognosis, and it is not known if they may benefit from complete revascularization after myocardial infarction (MI)., Objective: To investigate the benefit of physiology-guided complete revascularization vs a culprit-only strategy in patients with HBR, MI, and multivessel disease., Design, Setting, and Participants: This was a prespecified analysis of the Functional Assessment in Elderly MI Patients With Multivessel Disease (FIRE) randomized clinical trial data. FIRE was an investigator-initiated, open-label, multicenter trial. Patients 75 years or older with MI and multivessel disease were enrolled at 34 European centers from July 2019 through October 2021. Physiology treatment was performed either by angiography- or wire-based assessment. Patients were divided into HBR or non-HBR categories in accordance with the Academic Research Consortium HBR document., Interventions: Patients were randomized to either physiology-guided complete revascularization or culprit-only strategy., Main Outcomes and Measures: The primary outcome comprised a composite of death, MI, stroke, or revascularization at 1 year. Secondary outcomes included a composite of cardiovascular death or MI and Bleeding Academic Research Consortium (BARC) types 3 to 5., Results: Among 1445 patients (mean [SD] age, 81 [5] years; 917 male [63%]), 1025 (71%) met HBR criteria. Patients with HBR were at higher risk for the primary end point (hazard ratio [HR], 2.01; 95% CI, 1.47-2.76), cardiovascular death or MI (HR, 1.89; 95% CI, 1.26-2.83), and BARC types 3 to 5 (HR, 3.28; 95% CI, 1.40-7.64). The primary end point was significantly reduced with physiology-guided complete revascularization as compared with culprit-only strategy in patients with HBR (HR, 0.73; 95% CI, 0.55-0.96). No indication of interaction was noted between revascularization strategy and HBR status for primary and secondary end points., Conclusions and Relevance: HBR status is prevalent among older patients with MI, significantly increasing the likelihood of adverse events. Physiology-guided complete revascularization emerges as an effective strategy, in comparison with culprit-only revascularization, for mitigating ischemic adverse events, including cardiovascular death and MI., Trial Registration: ClinicalTrials.gov Identifier: NCT03772743.
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- 2024
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50. [Ticagrelor monotherapy in patients with acute coronary syndrome receiving new generation drug-eluting stents: results of the T-PASS randomized clinical trial].
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Ruggiero R, Beneduce A, Demola P, Pompei G, Barioli A, Ryan N, Barbato E, and Toselli M
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- Humans, Purinergic P2Y Receptor Antagonists administration & dosage, Purinergic P2Y Receptor Antagonists therapeutic use, Treatment Outcome, Male, Middle Aged, Platelet Aggregation Inhibitors administration & dosage, Platelet Aggregation Inhibitors therapeutic use, Female, Drug-Eluting Stents, Acute Coronary Syndrome therapy, Acute Coronary Syndrome drug therapy, Ticagrelor administration & dosage, Ticagrelor therapeutic use
- Published
- 2024
- Full Text
- View/download PDF
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