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7 results on '"Pommert, Nina Sophie"'

1. Tricuspid Regurgitation and TAVR: Outcomes, Risk Factors and Biomarkers

Author

Puehler, Thomas, primary, Pommert, Nina Sophie, additional, Freitag-Wolf, Sandra, additional, Seoudy, Hatim, additional, Ernst, Markus, additional, Haneya, Assad, additional, Sathananthan, Janarthanan, additional, Sellers, Stephanie L., additional, Meier, David, additional, Schöttler, Jan, additional, Müller, Oliver J., additional, Salehi Ravesh, Mona, additional, Saad, Mohammed, additional, Frank, Derk, additional, and Lutter, Georg, additional

Published
2024
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4. Optimization of Enzymatic and Chemical Decellularization of Native Porcine Heart Valves for the Generation of Decellularized Xenografts.

Author

Saeid Nia, Monireh, Floder, Lena Maria, Seiler, Jette Anika, Puehler, Thomas, Pommert, Nina Sophie, Berndt, Rouven, Meier, David, Sellers, Stephanie L., Sathananthan, Janarthanan, Zhang, Xiling, Hasler, Mario, Gorb, Stanislav N., Warnecke, Gregor, and Lutter, Georg

Subjects
HEART valves, XENOGRAFTS, HEART valve diseases, TRITON X-100, IMMUNE response, TISSUE engineering
Abstract

One of the most important medical interventions for individuals with heart valvular disease is heart valve replacement, which is not without substantial challenges, particularly for pediatric patients. Due to their biological properties and biocompatibility, natural tissue-originated scaffolds derived from human or animal sources are one type of scaffold that is widely used in tissue engineering. However, they are known for their high potential for immunogenicity. Being free of cells and genetic material, decellularized xenografts, consequently, have low immunogenicity and, thus, are expected to be tolerated by the recipient's immune system. The scaffold ultrastructure and ECM composition can be affected by cell removal agents. Therefore, applying an appropriate method that preserves intact the structure of the ECM plays a critical role in the final result. So far, there has not been an effective decellularization technique that preserves the integrity of the heart valve's ultrastructure while securing the least amount of genetic material left. This study demonstrates a new protocol with untraceable cells and residual DNA, thereby maximally reducing any chance of immunogenicity. The mechanical and biochemical properties of the ECM resemble those of native heart valves. Results from this study strongly indicate that different critical factors, such as ionic detergent omission, the substitution of Triton X-100 with Tergitol, and using a lower concentration of trypsin and a higher concentration of DNase and RNase, play a significant role in maintaining intact the ultrastructure and function of the ECM. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Producing and Testing Prototype Tissue-Engineered 3D Tri-Leaflet Valved Stents on Biodegradable Poly-ε-Caprolactone Scaffolds

Author

Lutter, Georg, primary, Pommert, Nina Sophie, additional, Zhang, Xiling, additional, Seiler, Jette, additional, Saeid Nia, Monireh, additional, Meier, David, additional, Sellers, Stephanie L., additional, Gorb, Stanislav N., additional, Hansen, Jan-Hinnerk, additional, Seoudy, Hatim, additional, Müller, Oliver J., additional, Saad, Mohammed, additional, Haneya, Assad, additional, Frank, Derk, additional, Puehler, Thomas, additional, and Sathananthan, Janarthanan, additional

Published
2023
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6. Transcatheter Mitral Valve Replacement

Author

Pommert, Nina Sophie, primary, Puehler, Thomas, additional, Meier, David, additional, Seoudy, Hatim, additional, Sathananthan, Janarthanan, additional, Sellers, Stephanie L., additional, Both, Marcus, additional, Saad, Mohammed, additional, Frank, Derk, additional, and Lutter, Georg, additional

Published
2023
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7. Transcatheter Aortic Valve Implantation by Intercostal Access: Initial Experience with a No-Touch Technique

Author

Pommert, Nina Sophie, primary, Zhang, Xiling, additional, Puehler, Thomas, additional, Seoudy, Hatim, additional, Huenges, Katharina, additional, Schoettler, Jan, additional, Haneya, Assad, additional, Friedrich, Christine, additional, Sathananthan, Janarthanan, additional, Sellers, Stephanie L., additional, Meier, David, additional, Mueller, Oliver J., additional, Saad, Mohammed, additional, Frank, Derk, additional, and Lutter, Georg, additional

Published
2023
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